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VEGFR-2/BRAF-IN-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-146492
    VEGFR-2/BRAF-IN-2

    		VEGFR Raf Apoptosis Cancer
    VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAF V600E and BRAF WT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase .
    <em>VEGFR-2</em>/<em>BRAF-IN-2</em>
  • HY-18318
    Takeda-6D

    		Raf VEGFR PERK Cancer
    Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity .
    Takeda-6D

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