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VH285-PEG4-C4-Cl

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111997
    VH285-PEG4-C4-Cl

    HaloPROTAC 3

    		 E3 Ligase Ligand-Linker Conjugates
    VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM .
    <em>VH285-PEG4-C4-Cl</em>

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