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Results for "

Water Inhibitors

" in MCE Product Catalog:

By Targets:	Apoptosis (3) Aquaporin (1) Autophagy (1) Bacterial (2) Carbonic Anhydrase (3) Dopamine Transporter (1) Endogenous Metabolite (1) GlyT (1) HIV Protease (1) HPPD (1) LPL Receptor (1) Mitochondrial Metabolism (1) Myosin (1) Opioid Receptor (1) PARP (2) Phosphatase (1) Phospholipase (1) Prostaglandin Receptor (1) Sodium Channel (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Endocrinology (2) Infection (2) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas

HY-B0544

Sodium Picosulfate
Sodium Picosulphate
Others Metabolic Disease

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Sodium Picosulfate Sodium Picosulphate	Others	Metabolic Disease
Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

HY-B1386

Halazone	Bacterial Carbonic Anhydrase Sodium Channel	Infection
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water.

HY-B1092A

Gluconate sodium D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt	Endogenous Metabolite	Others
Gluconate sodium (D-Gluconic acid sodium salt) is a corrosion and scale inhibitor of ordinary steel in simulated cooling water.

HY-B0302

Etidronic acid Etidronate; HEDPA; HEDP	Apoptosis	Cancer Metabolic Disease
Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water.

HY-B0302A

Etidronic acid disodium Etidronate disodium; HEDPA disodium; HEDP disodium	Apoptosis	Cancer Metabolic Disease
Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water.

HY-B0397

Dichlorphenamide Diclofenamide	Carbonic Anhydrase	Neurological Disease
Dichlorphenamide (Diclofenamide) is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research.

HY-B0397A

Dichlorphenamide disodium Diclofenamide disodium	Carbonic Anhydrase	Neurological Disease
Dichlorphenamide (Diclofenamide) disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research.

HY-111474

Para-aminoblebbistatin	Myosin	Neurological Disease Cardiovascular Disease
Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo.

HY-109542

Cyclopenthiazide	Others	Metabolic Disease
Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney.

HY-110200

TC AQP1 1 m-Phenylenediacrylic acid; m-Benzenediacrylic acid	Aquaporin	Cancer Metabolic Disease
TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC₅₀ of 8 μM.

HY-19232

R-87366	HIV Protease	Inflammation/Immunology
R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a K_i value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV).

HY-100287

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide	Prostaglandin Receptor Phospholipase	Endocrinology
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.

HY-116218

Amelparib JPI-289	PARP	Neurological Disease Cardiovascular Disease
Amelparib is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC₅₀ =18.5 nmol/L) and cellular PAR formation (IC₅₀ =10.7 nmol/L) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke.

HY-122666

Org 25935	GlyT	Metabolic Disease
Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC₅₀ value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse.

HY-118742

Benzobicyclon	HPPD	Others
Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.

HY-B0557

Bisacodyl	Dopamine Transporter Opioid Receptor	Metabolic Disease Cancer
Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE₂ by direct activation of colon macrophages. PGE₂ acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect.

HY-151340

Antitubercular agent-32	Bacterial	Infection
Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC₅₀=3.9 μM).

HY-W006566

5-AIQ 5-Aminoisoquinolin-1-one	PARP	Cancer
5-AIQ (5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the therapy conditions associated with ischemia-reperfusion of the liver.

HY-D1005

Poloxamer 407	LPL Receptor	Inflammation/Immunology
Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor.

HY-101180

C2 Ceramide Ceramide 2	Phosphatase Mitochondrial Metabolism Apoptosis Autophagy	Endocrinology Metabolic Disease
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss.

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library	408 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 408 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

408 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 408 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Cat. No.	Product Name	Type