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Results for "

Y4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (1) Autophagy (1) Neuropeptide Y Receptor (8) P2X Receptor (1) P2Y Receptor (9)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (7)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats .

HY-P1323A

[Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA 1 Publications Verification	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake .

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats .

HY-P1323

[Leu31,Pro34]-Neuropeptide Y (human,rat)	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake .

HY-107732

JNJ-5207787	Neuropeptide Y Receptor	Neurological Disease
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y₂ receptor (Y₂) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC₅₀s of 7.0 and 7.1 for human Y₂ receptor and rat Y₂ receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y₁, Y₄, and Y₅ receptors .

HY-107479

(R)-JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC₅₀ values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects .

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

HY-154840A

4-Thiouridine 5′-triphosphate tetrasodium 4-Thio-UTP tetrasodium	P2Y Receptor	Inflammation/Immunology
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium is a potent P2Y₂ and P2Y₄ receptor agonist, with EC₅₀s of 35 and 350 nM for hP2Y₂ and *hP2Y₄*, respectively. 4-Thiouridine 5′-triphosphate tetrasodium can be used in the study of crosslinking experiments, labeling of transcriptional complex .

HY-154840

4-Thiouridine 5′-triphosphate tetralithium 4-Thio-UTP tetralithium	P2Y Receptor	Inflammation/Immunology
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetralithium is a potent P2Y₂ and P2Y₄ receptor agonist, with EC₅₀s of 35 and 350 nM for hP2Y₂ and *hP2Y₄*, respectively. 4-Thiouridine 5′-triphosphate tetralithium can be used in the study of crosslinking experiments, labeling of transcriptional complex .

HY-108650

2-Thio-UTP tetrasodium 2-Thiouridine 5′-triphosphate tetrasodium	P2Y Receptor	Cancer
2-Thio-UTP tetrasodium is a potent P2Y₂, *P2Y₄* and P2Y₆ agonist, which an be used for the research of cancer .

HY-13104

MRS 2578 5 Publications Verification	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-110092

PSB-1114 tetrasodium	P2Y Receptor	Metabolic Disease
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors .

HY-110092A

PSB-1114 triethylamine	P2Y Receptor	Cancer
PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the *P2Y₄* (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors .

HY-110322A

PPTN	P2Y Receptor	Inflammation/Immunology
PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-110322

PPTN hydrochloride 1 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity .

HY-101044

PPADS tetrasodium 1 Publications Verification
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-101308

MRS2179 tetrasodium
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium inhibits platelet aggregation .

HY-101308A

MRS2179 tetrasodium hydrate	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium hydrate inhibits platelet aggregation .

HY-134807

Indophagolin	P2X Receptor 5-HT Receptor Autophagy	Cancer
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC₅₀=140 nM). Indophagolin antagonizes the purinergic receptor *P2X₄* as well as P2X₁ and P2X₃ with IC₅₀s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the G_q-protein-coupled P2Y₄, P2Y₆, and P2Y₁₁ receptors (IC₅₀s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT₆ (IC₅₀=1.0 μM) and a moderate effect on receptors 5-HT_1B, 5-HT_2B, 5-HT_4e, and 5-HT₇ .

Cat. No.	Product Name	Target	Research Area

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats .

HY-P3359

Y4R agonist-1

Peptides Others

Y4R agonist-1 is a Y₄R agonist with a K_i of 0.048 nM.
HY-P3360

Y4R agonist-2

Peptides Others

Y4R agonist-2 is a Y₄R agonist with a K_i of 0.033 nM.

Y4R agonist-1	Peptides	Others
Y4R agonist-1 is a Y₄R agonist with a K_i of 0.048 nM.

Y4R agonist-2	Peptides	Others
Y4R agonist-2 is a Y₄R agonist with a K_i of 0.033 nM.

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y₅ receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats .

HY-P1323

[Leu31,Pro34]-Neuropeptide Y (human,rat)	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake .

HY-P1323A

[Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA 1 Publications Verification	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake .

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

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