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Results for "

ZIKV

" in MCE Product Catalog:

28

Inhibitors & Agonists

1

Fluorescent Dye

4

Natural
Products

13

Recombinant Proteins

Cat. No. Product Name Target Research Areas
  • HY-151448
    ZIKV-IN-5

    Virus Protease Infection
    ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase.
  • HY-151447
    ZIKV-IN-4

    Virus Protease Infection
    ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase.
  • HY-146957
    ZIKV-IN-1

    Virus Protease Cancer
    ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 µM and EC90 of 6.8 µM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain.
  • HY-151445
    ZIKV-IN-2

    DNA Methyltransferase Virus Protease Infection
    ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV).
  • HY-151446
    ZIKV-IN-3

    DNA Methyltransferase Virus Protease Infection
    ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).
  • HY-151253
    CYP2C1/CYP2C19-IN-2

    Cytochrome P450 Virus Protease Infection
    CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV.
  • HY-151526
    LabMol-301

    Virus Protease Infection
    LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death.
  • HY-151251
    CYP2C9/CYP2C19-IN-1

    Cytochrome P450 Virus Protease Infection
    CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV.
  • HY-N1992
    Theaflavin 3,3'-digallate

    TF-3; ZP10

    Virus Protease HSV HIV Cancer Infection
    Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 µM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1. Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent.
  • HY-151254
    CYP2C19-IN-1

    Cytochrome P450 Influenza Virus DNA/RNA Synthesis Infection
    CYP2C19-IN-1 (compound 20d) is a potent CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) with a Ki value of 6.16 µM. CYP2C19-IN-1 can be used in study of anti-ZIKV.
  • HY-130437
    p-nitro-Pifithrin-α

    MDM-2/p53 TGF-β Receptor Caspase Infection Metabolic Disease
    p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease.
  • HY-B0961
    Merbromin

    Mercury dibromofluorescein disodium salt; ZP1

    Bacterial Others
    Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye. Merbromin is a potent inhibitor against Zika virus (ZIKV) replication. Merbromin shows anti-ZIKV potency through ZIKVpro inhibition.
  • HY-16696
    SN 2

    TRP Channel Infection
    SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV).
  • HY-146193
    Zika virus-IN-3

    Others Infection
    Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC50 of 3.4 μM .
  • HY-146191
    Zika virus-IN-1

    Others Infection
    Zika virus-IN-1 (Compd 2) is a Zika virus inhibitor, with an EC50 of 1.56 μM .
  • HY-146192
    Zika virus-IN-2

    Others Infection
    Zika virus-IN-2 (Compd 3) is a Zika virus inhibitor, with an EC50 of 7.4 μM .
  • HY-144742
    NS2B/NS3-IN-6

    Virus Protease Infection
    NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively.
  • HY-144740
    NS2B/NS3-IN-5

    Virus Protease Infection
    NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively.
  • HY-144736
    NS2B/NS3-IN-4

    Virus Protease Infection
    NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively.
  • HY-N4118
    Cephaeline

    (-)-Cephaeline; NSC 32944 free base

    Influenza Virus Filovirus Infection
    Cephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
  • HY-108462
    ML-SA1

    TRP Channel Infection
    ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.
  • HY-N0838
    Cephalotaxine

    (-)-Cephalotaxine; ZINC19795976

    Influenza Virus Cancer Infection
    Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus drupacea, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity.
  • HY-N2076
    Cephaeline hydrochloride

    (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride

    Influenza Virus Filovirus Infection
    Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
  • HY-115918
    XA-E

    Xanthoangelol E

    Others Infection
    XA-E is a compound purified from a methanol-ethyl acetate extract from A. keiskei. XA-E displays anti-ZIKV activity with an IC50 value of 22.0 µM.
  • HY-10396
    Emricasan

    PF 03491390; IDN-6556

    Caspase Influenza Virus Cancer Infection Neurological Disease
    Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.
  • HY-150600
    NS2B/NS3-IN-7

    Virus Protease Infection
    NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.
  • HY-W015764
    T-1105

    Influenza Virus Infection
    T-1105, a structural analogue of T-705, is a novel broad-spectrum viral polymerase inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase.
  • HY-100604
    JNJ-40418677

    γ-secretase Amyloid-β Neurological Disease
    JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research.