Zn2

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (2) Cholinesterase (ChE) (1) Fluorescent Dye (10) GHSR (1) HDAC (2) iGluR (1) Isotope-Labeled Compounds (1) Reactive Oxygen Species (1) SOD (1)
By Research Areas:	Cancer (5) Endocrinology (1) Infection (1) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0156

ZnAF-1	Fluorescent Dye	Others
ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .

HY-126823

Phen Green SK diacetate (5/6-mixture) 2 Publications Verification PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+. PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions

HY-D0157

ZnAF-2 ZnAF2; ZnAF 2; 4-[(2-{Bis[(pyridin-2-YL)methyl]amino}ethyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-YL)benzoic acid	Biochemical Assay Reagents	Others
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-B1159S

Nitroxoline-D4 8-Hydroxy-5-nitroquinoline-d₄; 5-Nitro-8-quinolinol-d₄	Bacterial Autophagy Antibiotic	Infection Cancer
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix[1][2].

HY-D0158

ZnAF-2 DA

Biochemical Assay Reagents Others

ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

ZnAF-2 DA	Biochemical Assay Reagents	Others
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

HY-D1894

5-Br-PAPS	Fluorescent Dye	Others
5-Br-PAPS is a highly specific Zn ²⁺ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn ²⁺ by forming a deeply colored red Zn ²⁺ complex .

HY-D1264

PMQA Zn-green	Fluorescent Dye	Others
PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn ²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn ²⁺ in living cells .

HY-108699

TM-N1324	GHSR	Neurological Disease Endocrinology
TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC₅₀s of 9 nM/5 nM in the presence of Zn ²⁺, and 280 nM/180 nM in the absence of Zn ²⁺ for human/murine GPR39.

HY-D0982

Zinquin

Fluorescent Dye Others

Zinquin is a fluorescent sensor and used to observe reactive Zn ²⁺.λex/λem=368/490 nm.
HY-D1441

Zinquin AM ester

Fluorescent Dye Others

Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .
HY-162158

DA ZP1

Fluorescent Dye Others

DA ZP1 is a fluorogenic Zn(II) sensor (K_d Zn ²⁺ = 0.6 nM) . Ex / Em = 490 / 522 nm

Zinquin	Fluorescent Dye	Others
Zinquin is a fluorescent sensor and used to observe reactive Zn ²⁺.λex/λem=368/490 nm.

Zinquin AM ester	Fluorescent Dye	Others
Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .

DA ZP1	Fluorescent Dye	Others
DA ZP1 is a fluorogenic Zn(II) sensor (K_d Zn ²⁺ = 0.6 nM) . Ex / Em = 490 / 522 nm

HY-E70199

Aminopeptidase N (rat) APN/CD13	Others	Others
A Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺ dependent membrane-bound ectopeptidase that degrades preferentially proteins and peptides with a N-terminal neutral amino acid .

HY-119287

TSQ	Fluorescent Dye	Others
TSQ is a cytosolic zinc fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-146669

BChE-IN-6	Cholinesterase (ChE)	Neurological Disease
BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a K_i of 0.182 μM. BChE-IN-6 shows chelating capacity on Zn ²⁺. BChE-IN-6 can be used for Alzheimer’s disease (AD) research .

HY-P1285

Conantokin R Con-R	iGluR	Neurological Disease
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn ²⁺ and Mg ²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity ^[2].

HY-10528

Tasquinimod 5+ Cited Publications ABR-215050	HDAC	Cancer
Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

HY-124171

Zinquin ethyl ester	Fluorescent Dye	Others
Zinquin ethyl ester is a fluorescent derivative of Zinquin and is a fluorescent probe of cytosolic zinc. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-16074

ATN-224 3 Publications Verification Bis(choline)tetrathiomolybdate	SOD	Cancer
ATN-224 is an oral Cu ²⁺/Zn ²⁺-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC₅₀ of 17.5±3.7 nM.

HY-100202

TPEN Maximum Cited Publications 12 Publications Verification TPEDA	Reactive Oxygen Species Apoptosis Autophagy	Cancer
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn ²⁺, but a lower affinity for Mg ²⁺ and Ca ²⁺. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis ^[2] .

HY-D0159

ZnAF-1F	Fluorescent Dye	Others
ZnAF-1F is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

HY-B0600

Tafluprost AFP-168; MK2452	Others	Others
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn ²⁺-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma ^[2] .

HY-10528S

Tasquinimod-d3 ABR-215050-d₃	HDAC Isotope-Labeled Compounds	Cancer
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

Cat. No.	Product Name	Type

HY-D0156

ZnAF-1	Fluorescent Dyes/Probes
ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry .

HY-D0982

Zinquin

Fluorescent Dyes/Probes

Zinquin is a fluorescent sensor and used to observe reactive Zn ²⁺.λex/λem=368/490 nm.

Zinquin	Fluorescent Dyes/Probes
Zinquin is a fluorescent sensor and used to observe reactive Zn ²⁺.λex/λem=368/490 nm.

HY-119287

TSQ	Dyes
TSQ is a cytosolic zinc fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-D1894

5-Br-PAPS	Fluorescent Dyes/Probes
5-Br-PAPS is a highly specific Zn ²⁺ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn ²⁺ by forming a deeply colored red Zn ²⁺ complex .

HY-D1264

PMQA Zn-green	Fluorescent Dyes/Probes
PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn ²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn ²⁺ in living cells .

HY-124171

Zinquin ethyl ester	Fluorescent Dyes/Probes
Zinquin ethyl ester is a fluorescent derivative of Zinquin and is a fluorescent probe of cytosolic zinc. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence .

HY-D0159

ZnAF-1F	Fluorescent Dyes/Probes
ZnAF-1F is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn ²⁺ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm ^[2] .

Cat. No.	Product Name	Type

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺) ^[2].

HY-D0157

ZnAF-2 ZnAF2; ZnAF 2; 4-[(2-{Bis[(pyridin-2-YL)methyl]amino}ethyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-YL)benzoic acid	Biochemical Assay Reagents
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .

HY-D0158

ZnAF-2 DA

Biochemical Assay Reagents

ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

ZnAF-2 DA	Biochemical Assay Reagents
ZnAF-2DAavailable for testing Zn(2+)fluorescence, as Zn(2+)Probe (after esterase hydrolysis).

Cat. No.	Product Name	Target	Research Area

HY-P1285

Conantokin R Con-R	iGluR	Neurological Disease
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn ²⁺ and Mg ²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity ^[2].

Cat. No.	Product Name	Chemical Structure

HY-B1159S

Nitroxoline-D4
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix[1][2].

HY-10528S

Tasquinimod-d3
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor ^[2] .

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Fluorescent Dye

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds