adiponectin

By Targets:	Adiponectin Receptor (4) Adrenergic Receptor (2) Antibiotic (2) Apoptosis (2) Autophagy (2) Bacterial (2) Cathepsin (1) Elastase (1) Endogenous Metabolite (1) Glucocorticoid Receptor (1) GLUT (1) Insulin Receptor (1) Isotope-Labeled Compounds (1) NF-κB (1) P2X Receptor (1) p38 MAPK (2) Parasite (2) PKC (1) PPAR (3) Reverse Transcriptase (2) Src (1)
By Research Areas:	Cancer (4) Endocrinology (3) Infection (4) Inflammation/Immunology (5) Metabolic Disease (9)

Targets Recommended: Adiponectin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0887

Isoastragaloside I 1 Publications Verification Isoastragaloside-I	Others	Metabolic Disease
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.

HY-N0755

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-136888

MeOSuc-AAPV-CMK Elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

HY-147511

PPARγ agonist 7	PPAR	Others
PPARγ agonist 7 (Compound 3a) is a potent and selective agonist of PPARγ. PPARγ agonist 7 promotes adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs) as a novel PPARγ full agonist (EC₅₀, 4.34 μM) .

HY-147757

PPARγ/δ modulator 1	PPAR	Metabolic Disease
PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with K_i values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC₅₀ of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively .

HY-15848

AdipoRon 15+ Cited Publications	Adiponectin Receptor	Metabolic Disease
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K_ds of 1.8 and 3.1 μM, respectively.

HY-N0384S4

Homovanillic acid-d3-1 Vanilacetic acid-d₃-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .

HY-151963

PPARγ/GR modulator 1	PPAR Glucocorticoid Receptor	Metabolic Disease
PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with K_is of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Others	Metabolic Disease
3,5,7,3′,4′-Pentamethoxyflavone is a polymethoxyflavonoid that can be extracted from Kaempferia parviflora. 3,5,7,3′,4′-Pentamethoxyflavone can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation .

HY-N0166

Gramine 2 Publications Verification Donaxine	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N9182

Zeaxanthin dipalmitate Physalien	Adiponectin Receptor P2X Receptor Autophagy	Inflammation/Immunology
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

HY-112291

SB 220025	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 also inhibits p56 ^Lck and PKC with IC₅₀ values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-N0166R

Gramine (Standard) Donaxine (Standard)	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N3007A

(E)-Naringenin chalcone	Others	Inflammation/Immunology
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-B0318

Metronidazole Maximum Cited Publications 23 Publications Verification	Bacterial Parasite Apoptosis Antibiotic	Infection Inflammation/Immunology Cancer
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections .

HY-B0318A

Metronidazole hydrochloride SC 326421	Antibiotic Bacterial Parasite Apoptosis	Infection Inflammation/Immunology
Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application .

Cat. No.	Product Name	Target	Research Area

HY-136888

MeOSuc-AAPV-CMK Elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0887

Isoastragaloside I 1 Publications Verification Isoastragaloside-I	Triterpenes Structural Classification other families Classification of Application Fields Leguminosae Terpenoids Source classification Metabolic Disease Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields	Others
Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.

HY-N0755

Rhoifolin	Structural Classification Rhus succedanea Flavonoids Classification of Application Fields Flavones Plants Disease Research Fields Endocrinology Cancer Anacardiaceae	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Metabolic Disease Plants Disease Research Fields Zingiberaceae	Others
3,5,7,3′,4′-Pentamethoxyflavone is a polymethoxyflavonoid that can be extracted from Kaempferia parviflora. 3,5,7,3′,4′-Pentamethoxyflavone can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation .

HY-N0166

Gramine 2 Publications Verification Donaxine	Infection Alkaloids Classification of Application Fields Gramineae Source classification Metabolic Disease Plants Disease Research Fields Endocrinology Arundo donax Linn. Indole Alkaloids	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase
Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N9182

Zeaxanthin dipalmitate Physalien	Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Solanaceae Lycium chinense Miller Disease Research Fields Inflammation/Immunology	Adiponectin Receptor P2X Receptor Autophagy
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

HY-N0166R

Gramine (Standard) Donaxine (Standard)	Infection Structural Classification Alkaloids Classification of Application Fields Gramineae Source classification Metabolic Disease Plants Disease Research Fields Endocrinology Arundo donax Linn.	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

HY-N3007A

(E)-Naringenin chalcone	Structural Classification Phenols Polyphenols Lycopersicon esculentum Miller Plants Solanaceae	Others
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-B0318

Metronidazole Maximum Cited Publications 23 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Parasite Apoptosis Antibiotic
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections .

Recombinant Proteins Recommended:

Adiponectin

Species:	Human (7) Mouse (4) Bovine (1) Cynomolgus (1)
Tag:	His (6) SUMO (1) Tag Free (6) Myc (1) Fc (1) Flag (1)
Source:	HEK293 (5) E. coli Cell-free (3) CHO (1) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7461

	Adiponectin/Acrp30 Protein, Mouse (HEK293, His) 1 Publications Verification rMuadiponectin, His; Acrp30; ADIPOQ	Mouse	HEK293
	Adiponectin/Acrp30 Protein, Mouse (HEK293, His) is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease.

HY-P70504

	Adiponectin/Acrp30 Protein, Human (HEK293, His) 1 Publications Verification adiponectin; 30 kDa Adipocyte Complement-Related Protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and Collagen Domain-Containing Protein; Adipose Most Abundant Gene Transcript 1 Protein; apM-1; Gelatin-Binding Protein; ADIPOQ; ACDC; ACRP3	Human	HEK293
	Adiponectin/Acrp30 Protein, Human (HEK293, His) could increase cell sensitivity to insulin and can be used as a potential protein for treating diabetic tendinopathy.

HY-P7358

	Adiponectin/Acrp30 Protein, Mouse (144a.a) rMugAcrp30/Adipolean; adiponectin; ACRP30; APM-1; ADIPOQ; ACDC	Mouse	E. coli
	Adiponectin/Acrp30 Protein, Mouse (144a.a) is an adipose-derived hormone, plays an important role in regulating energy homeostasis and insulin sensitivity.

HY-P78234

	Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) ACDC; Acrp30; ADPN; adiponectin; AdipoQ; ADIPQTL1; APM1APM-1; GBP28; GBP28apM1; APM-1; APM1	Mouse	HEK293
	Adiponectin/Acrp30 Protein is a protein hormone and adipokine, the most abundant peptide secreted by adipocytes, which is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin plays a inportant role in obesity-related diseases, insulin resistance/type 2 diabetes and cardiovascular disease. Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Adiponectin/Acrp30 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) is 230 a.a., with molecular weight of 52-70 kDa.

HY-P700948

	Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His) rMuadiponectin, His; Acrp30; ADIPOQ	Cynomolgus	HEK293
	Adiponectin/Acrp30 protein regulates fat metabolism and insulin sensitivity and has antidiabetic, antiatherosclerotic, and anti-inflammatory effects. It stimulates AMPK phosphorylation, enhancing glucose utilization and fatty acid burning. Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Adiponectin/Acrp30 protein, expressed by HEK293 , with C-His labeled tag. The total length of Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His) is 227 a.a., with molecular weight of 30-40 kDa.

HY-P7126

	Adiponectin/Acrp30 Protein, Human (CHO) rHuadiponectin; Acrp-30; GBP-28; Apm-1; Acrp 30; Acrp30	Human	CHO
	Adiponectin/Acrp30 Protein, Human (CHO) could increase cell sensitivity to insulin and can be used as a potential protein for treating diabetic tendinopathy

HY-P7127

	Adiponectin/Acrp30 Protein, Human (HEK293) rHuadiponectin; Acrp-30; GBP-28; Apm-1; Acrp 30; Acrp30	Human	HEK293
	Adiponectin/Acrp30 Protein, Human (HEK293) could increase cell sensitivity to insulin and can be used as a potential protein for treating diabetic tendinopathy.

HY-P7128

	Adiponectin/Acrp30 Protein, Human (277a.a) rHuadiponectin; Acrp-30; GBP-28; Apm-1; Acrp 30; Acrp30	Human	E. coli
	Adiponectin/Acrp30 Protein, Human (277a.a) could increase cell sensitivity to insulin and can be used as a potential protein for treating diabetic tendinopathy.

HY-P7129

	Adiponectin/Acrp30 Protein, Mouse (227a.a) 1 Publications Verification rMuadiponectin; Acrp-30; GBP-28; Apm-1; Acrp 30; Acrp30	Mouse	E. coli
	Adiponectin/Acrp30 Protein, Mouse (227a.a) suppresses endothelial inflammatory response and vascular smooth muscle cell proliferation, as well as macrophage-to-foam cell transformation.

HY-P702199

	ADIPOR1 Protein, Human (Cell-Free) adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with tag free. The total length of ADIPOR1 Protein, Human (Cell-Free) is 287 a.a., with molecular weight of 33.0 kDa.

HY-P702200

	ADIPOR1 Protein, Human (Cell-Free, His, Flag) adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free, His, Flag) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with N-6*His, N-Flag labeled tag. The total length of ADIPOR1 Protein, Human (Cell-Free, His, Flag) is 287 a.a., with molecular weight of 34.8 kDa.

HY-P702201

	ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is 375 a.a., with molecular weight of 62.6 kDa.

HY-P71827

	Adiponectin/Acrp30 Protein, Bovine (P.pastoris, His) ADIPOQ; ACRP30Adipocyte complement-related 30kDa protein; ACRP30; Adipocyte; C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1	Bovine	P. pastoris
	Adiponectin/Acrp30 Protein, Bovine (P.pastoris, His) can increase cell sensitivity to insulin and can be used as a potential protein for diabetic tendinopathy research.


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Cat. No.	Product Name	Chemical Structure

HY-N0384S4

Homovanillic acid-d3-1
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .

Cat. No.	Product Name	Application	Reactivity

HY-P82955

Adiponectin Receptor 1 Antibody (YA2700)

adiponectin receptor protein 1; Progestin and adipoQ receptor family member I; CGI-45; PAQR1; ADIPOR1
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P80005

Adiponectin receptor protein 1 Antibody ACDCR1; ADIPO R1; adiponectin receptor protein 1; ADIPOR 1; ADIPOR1; CGI-45; CGI-45 protein; FLJ25385; PAQR1; Progestin and adipoQ receptor family member I; TESBP1A; ADR1_HUMAN.	ICC/IF, IHC-P, FC	Human, Mouse
Adiponectin receptor protein 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Adiponectin receptor protein 1. It can be used for ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80004

Adiponectin Antibody 30 kDa adipocyte complement related protein; ACDC; ACRP 30; ACRP30; ADIPO_HUMAN; Adipocyte; AdipoQ; Adipose most abundant gene transcript 1; Adipose specific collagen like factor; ADIPQTL1; ADPN; APM 1; apM-1; ApM1; C1q and collagen domain-containing protein; GBP 28; GBP28; Gelatin binding protein; Gelatin binding protein 28; Gelatin-binding protein.	WB, ICC, IHC-P	Mouse
Adiponectin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 27 kDa, targeting to Adiponectin. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Mouse.

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adiponectin

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