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Isoforms Recommended:	ALDH1

Results for "

aldh1a1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (17) Apoptosis (3) Chemerin Receptor (1) Cholinesterase (ChE) (1) Epigenetic Reader Domain (1) Necroptosis (1) PROTACs (1) Small Interfering RNA (siRNA) (5)
By Research Areas:	Cancer (17) Metabolic Disease (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126003

ALDH1A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295) .

HY-RS00560

ALDH1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ALDH1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for ALDH1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ALDH1A1 Human Pre-designed siRNA Set A ALDH1A1 Human Pre-designed siRNA Set A

HY-RS00561

Aldh1a1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Aldh1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aldh1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aldh1a1 Mouse Pre-designed siRNA Set A Aldh1a1 Mouse Pre-designed siRNA Set A

HY-RS00562

ALDH1A1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ALDH1A1 Rat Pre-designed siRNA Set A contains three designed siRNAs for ALDH1A1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ALDH1A1 Rat Pre-designed siRNA Set A ALDH1A1 Rat Pre-designed siRNA Set A

HY-146240

ALDH1A1-IN-3	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC₅₀ value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement .

HY-158026

ALDH1A1-IN-5	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC₅₀ value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC) .

HY-157872

ALDH1A1-IN-4	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC₅₀ value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research .

HY-157567

FSI-TN42

N42
Aldehyde Dehydrogenase (ALDH) Metabolic Disease

ALDH1A1/2-IN-1 is an ALDH1A1 and ALDH1A2 inhibitor that can be used for preventing spermatogenesis .
HY-112278

NCT-506

Aldehyde Dehydrogenase (ALDH) Cancer

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM .
HY-110294

CM037

A37
Aldehyde Dehydrogenase (ALDH) Cancer

CM037 is a selective inhibitor of ALDH1A1 (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM .

FSI-TN42 N42	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH1A1/2-IN-1 is an *ALDH1A1* and *ALDH1A2* inhibitor that can be used for preventing spermatogenesis .

NCT-506	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM .

CM037 A37	Aldehyde Dehydrogenase (ALDH)	Cancer
CM037 is a selective inhibitor of *ALDH1A1* (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM .

HY-135841

CM10	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease Cancer
CM10 is a potent and selective *aldehyde dehydrogenase 1A (ALDH1A) family* inhibitor, with IC₅₀s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity .

HY-138097

α-NETA 5 Publications Verification	Chemerin Receptor Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis	Cancer
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity .

HY-112277

NCT-505	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC₅₀ of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC₅₀s, >57, 22.8, 20.1, >57 μM).

HY-18768

NCT-501 4 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀ of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM).

HY-18768A

NCT-501 hydrochloride	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀ of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM) .

HY-146683

KS106	Aldehyde Dehydrogenase (ALDH) Apoptosis	Cancer
KS106 is a potent *ALDH* inhibitor with IC₅₀s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase .

HY-146682

KS100	Aldehyde Dehydrogenase (ALDH) Apoptosis	Cancer
KS100 is a potent *ALDH* inhibitor with IC₅₀s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase .

HY-122912

ALDH1A inhibitor 673A aldh1Ai 673A	Aldehyde Dehydrogenase (ALDH) Necroptosis	Cancer
ALDH1A inhibitor 673A is an *ALDH1A* inhibitor. ALDH1A inhibitor 673A inhibits all three ALDH1A family members (IC₅₀: 246 nM, 230 nM, 348 nM for ALDH1A1, ALDH1A2, ALDH1A3 respectively. ALDH1A inhibitor 673A induces necroptotic cell death preferentially in CD133+ ovarian CSCs. ALDH1A inhibitor 673A also inhibits chemotherapy-resistant tumor growth .

HY-155816

PROTAC NSD3 degrader-1	PROTACs	Cancer
PROTAC NSD3 degrader-1 (compound 56) is a PROTAC targeting to Nuclear receptor binding SET domain protein NSD3. PROTAC NSD3 degrader-1 specifically induces NSD3 degradation with DC50 values of 1.43 and 0.94 μM in lung cancer cells NCI-H1703 and A549, respectively. PROTAC NSD3 degrader-1 suppresses the methylation of H3K36, induces apoptosis, and causes cell-cycle arrest. PROTAC NSD3 degrader-1 also downregulates the expression of NSD3-associated genes such as CDC25A, ALDH1A1, and IGFBP.

HY-RS00566

ALDH1L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ALDH1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for ALDH1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ALDH1L1 Human Pre-designed siRNA Set A ALDH1L1 Human Pre-designed siRNA Set A

HY-RS00565

ALDH1B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ALDH1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for ALDH1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ALDH1B1 Human Pre-designed siRNA Set A ALDH1B1 Human Pre-designed siRNA Set A

HY-123621

GNE-375	Epigenetic Reader Domain	Cancer
GNE-375 is a potent and highly selective BRD9 inhibitor with an IC₅₀ of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin .

HY-148466

IGUANA-1	Aldehyde Dehydrogenase (ALDH)	Cancer
IGUANA-1 is a potent inhibitor of *ALDH1B1*, which is a mitochondrial enzyme that promotes colorectal and pancreatic cancer. IGUANA-1 has significant inhibition against cancer cells .

HY-148243

IGUANA-1 free base STL5-T-0057	Aldehyde Dehydrogenase (ALDH)	Cancer
IGUANA-1 free base (STL5-T-0057) is an selective *ALDH1 B1* inhibitor with an IC₅₀ value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC₅₀ values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer .

Cat. No.	Compare	Product Name	Species	Source

HY-P7474

	ALDH1A1 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A1, His; aldh-1a1; Aldehyde Dehydrogenase 1-A1	Human	E. coli
	ALDH1A1 Protein, Human (His) is a human recombinant ALDH1A1 with an N-terminal Met and His tag produced in E. coli. ALDH1A1 Protein, Human (His) contains 501 amino acids (1-501 a.a.).


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ALDH1A1 Antibody aldh1a1; ALDC; aldh1; PUMB1; Retinal dehydrogenase 1; Raldh 1; Raldh1; aldh-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase; cytosolic	WB, IHC-P, IP	Human, Mouse
ALDH1A1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 55 kDa, targeting to ALDH1A1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse.

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