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alpha+1B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (12) Adenosine Receptor (2) Adrenergic Receptor (54) Akt (2) Bacterial (2) Calcium Channel (3) Chloride Channel (2) Dopamine Receptor (6) Endogenous Metabolite (6) Epigenetic Reader Domain (1) FOXO (1) Isotope-Labeled Compounds (8) mAChR (1) Reference Standards (9) Ribosomal S6 Kinase (RSK) (1) Sodium Channel (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (28) Endocrinology (26) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (16)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0471

Phenylephrine hydrochloride 30+ Cited Publications (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-15780

Brexpiprazole 5+ Cited Publications OPC-34712	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human *5-HT1A* and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM) ^[1] .

HY-10122

Silodosin 5 Publications Verification KAD 3213; KMD 3213	Adrenergic Receptor Bacterial	Endocrinology Cancer
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active **α1A-adrenergic receptor (α1A-AR)** blocker. Silodosin exhibits high affinity for α1A-AR (K_i=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH ^[1] .

HY-101385

L-765314 2 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
L-765314 is a potent and selective α1b adrenergic receptor antagonist with K_is of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

HY-101300

Cirazoline hydrochloride LD 3098 hydrochloride	Adenosine Receptor	Neurological Disease
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full **α1A-adrenergic receptor (α1A-AR) agonist (K_i*=120 nM) and only a partial agonist at α1B-AR* (K_i= 960 nM) and α1D-AR (K_i=660 nM) ^[1].

HY-B0391

Naftopidil 1 Publications Verification KT-611; BM-15275	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-100554

BMY 7378 2 Publications Verification	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease
BMY 7378 is a selective antagonist of α_1D-adrenoceptor (α_1D-AR). BMY 7378 binds to membranes expressing the cloned rat α_1D-AR with a >100-fold higher affinity (K_i=2 nM) than binding to either the cloned rat α_1A-AR (K_i=800 nM) or the hamster α_1B-AR (K_i=600 nM). BMY 7378 is a *5-HT_1A* receptor partial agonist ^[1] .

HY-103100

SB-699551 1 Publications Verification	5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SB-699551 is a selective and brain penetrant 5-HT5A receptor antagonist with a pK_i of 8.2 nM. SB-699551 shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 can be used for the research of anxiety, breast cancer, and Alzheimer's disease ^[1] .

HY-D1606

BODIPY FL prazosin	Adrenergic Receptor	Metabolic Disease
BODIPY FL prazosin is a fluorescent *α1-adrenergic* antagonist with K_i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes ^[1] .

HY-B1371A

Spiperone hydrochloride 2 Publications Verification Spiroperidol hydrochloride	Dopamine Receptor 5-HT Receptor Adrenergic Receptor Chloride Channel	Neurological Disease Inflammation/Immunology
Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D₂ receptor (K_i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors, respectively) and 5-HT_2A/5-HT_1A receptor (K_is of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective *α1B-adrenoceptor* antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities ^[1] .

HY-15780S1

Brexpiprazole-d8-1 OPC-34712-d₈-1	Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Brexpiprazole-d₈-1 (OPC-34712-d₈-1) is the deuterium labeled Brexpiprazole (HY-15780) ^[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human *5-HT1A* and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) .

HY-B0484

Buflomedil hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Buflomedil hydrochloride, a vasodilator agent, is an orally active *α1A-adrenoceptor* antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders ^[1] .

HY-U00399A

Fiduxosin hydrochloride ABT 980	Adrenergic Receptor	Endocrinology
Fiduxosin hydrochloride (ABT 980) is a potent *α1-adrenoceptor* antagonist, with K_i of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively ^[1].

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0371B

(R)-Terazosin	Adrenergic Receptor	Endocrinology
(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent *α1-adrenoceptor* antagonist with K_i values of 6.51 nM, 1.01 nM and 1.97 nM for *α1a, α1b* and *α1d-adrenoceptor*, respectively ^[1].

HY-103204

RS100329 hydrochloride	Adrenergic Receptor	Endocrinology
RS100329 hydrochloride is a potent and selective *α1A-adrenoceptor* antagonist with pK_i values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia ^[1] .

HY-118335

Prazobind SZL 49	Adrenergic Receptor	Cardiovascular Disease
Prazobind (SZL 49), a prazosin analog, is an irreversible *α1-adrenoceptor* antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure ^[1] .

HY-B0371D

(S)-Terazosin	Adrenergic Receptor	Endocrinology
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity *α-adrenoceptor* antagonist with K_i values of 3.91 nM, 0.79 nM and 1.16 nM for *α1a, α1b* and *α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B* and *α2c*-adrenoceptor with K_i values of 729 nM, 3.5 nM and 46.4 nM, respectively ^[1].

HY-15780R

Brexpiprazole (Standard) OPC-34712 (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (Standard) is the analytical standard of Brexpiprazole. This product is intended for research and analytical applications. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human *5-HT1A* and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM) ^[1] .

HY-15780S

Brexpiprazole-d8 OPC-34712-d₈	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole-d₈ (OPC-34712-d₈) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human *5-HT1A* and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) ^.

HY-U00399

Fiduxosin	Adrenergic Receptor	Endocrinology
Fiduxosin is a potent *α1-adrenoceptor* antagonist, with K_i of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.

HY-15780A

Brexpiprazole hydrochloride OPC-34712 hydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic agent, is a partial agonist of human *5-HT1A* and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM) ^[1] .

HY-W471937

α1B-AR antagonist 1	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
α1b-AR antagonist 1 (Compound Cpd1) is a selective *α₁B-AR* antagonist. Alpha1b-ar antagonist 1 can be used in the study of cardiovascular and central nervous system diseases ^[1].

HY-103209

Rec 15/2615 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with K_i values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement ^[1] .

HY-B0471S

Phenylephrine-d3 hydrochloride (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride (R)-(-)-Phenylephrine-2,4,6-d3 hydrochloride; L-Phenylephrine-2,4,6-d3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-19268

GG-818 GW 1818	Adrenergic Receptor	Metabolic Disease
GG-818 (GW 1818) is a potent and selective α1 adrenoceptor antagonist, with pK_i values of 9.7 for *α1_a, 7.8 for α1_b, and 7.6 for α1_d*. GG-818 (GW 1818) can be used for benign prostatic hyperplasia research ^[1].

HY-B0391A

Naftopidil dihydrochloride KT-611 dihydrochloride; BM-15275 dihydrochloride	Adrenergic Receptor	Cancer
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia ^[1] .

HY-175669

ANO1-IN-5	Chloride Channel	Metabolic Disease Endocrinology
ANO1-IN-5 is an orally active *ANO1* inhibitor with an IC₅₀ of 4.57 μM. J ANO1-IN-5 demonstrates 118-, 642-, and 10000-fold selectivity over α_1A-,α_1B-, andα_1D-AR, respectively. ANO1-IN-5 exhibits significant inhibitory effects on osteoclast differentiation and function. ANO1-IN-5 can used for the study of osteoporosis ^[1].

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs ^[1].

HY-123368

Zolertine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Zolertine hydrochloride is an *α-adrenoceptor* antagonist with a pK_i of 6.81 in rat liver (α_1B-adrenoceptors) and 6.35 in rabbit liver (α_1A-adrenoceptors) membranes ^[1].

HY-100980

HEAT hydrochloride BE2254 hydrochloride	Adrenergic Receptor	Neurological Disease Cancer
HEAT (BE2254) hydrochloride is a selective _{alpha 1 adrenergic receptor} antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pK_is of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively ^[1] .

HY-119262

ABT-866	Adrenergic Receptor	Cardiovascular Disease Endocrinology
ABT-866 is an *α_1A-adrenoceptor* agonist and an antagonist at the *α_1B- and α_1D-adrenoceptor* subtypes. ABT-866 has an EC₅₀ of 0.60 μM for the *α_1A* in the rabbit urethra. ABT-866 has a pA₂ value of 5.4 for the *α_1B* in the rat spleen. ABT-866 has a pA₂ value of 6.2 for the *α_1D* in the rat aorta. ABT-866 exhibits good urethral selectivity and lower cardiovascular side effects in stress urinary incontinence models. ABT-866 can be used for the research of diseases such as stress urinary incontinence ^[1] .

HY-B0471S3

Phenylephrine-d6 hydrochloride (R)-(-)-Phenylephrine-d6 hydrochloride; L-Phenylephrine-d6 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0484A

Buflomedil	Adrenergic Receptor	Cardiovascular Disease
Buflomedil, a vasodilator agent, is an orally active *α1A-adrenoceptor* antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders ^[1] .

HY-101345

AH 11110A	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
AH 11110A is an α_1B-adrenoceptor antagonist, but it can't effectively distinguish between the different subtypes of alpha(1) adrenoceptors (A, B, and D), nor can it clearly differentiate between alpha(1) and alpha(2) adrenoceptors ^[1] .

HY-B0391B

Naftopidil hydrochloride KT-611 hydrochloride; BM-15275 hydrochloride	Adrenergic Receptor	Cancer
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia ^[1].

HY-135478

LY393615 NCC1048	Calcium Channel Sodium Channel	Neurological Disease
LY393615 (NCC1048) is a novel neuronal Ca ²⁺ (calcium channel) and Na ⁺ channel (sodium channel) blocker with IC₅₀s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research ^[1].

HY-W724254

SNAP-6201	Adrenergic Receptor	Endocrinology
SNAP-6201 is a selective α_1a adrenoceptor antagonist with a K_i of 0.2 nM. SNAP-6201 exhibits >1400-fold selectivity over α_1b and α_1d adrenoceptors. SNAP-6201 exhibits excellent selectively to inhibit intraurethral pressure (IUP) in the anesthetized dog model. SNAP-6201 can be used for benign prostatic hyperplasia (BPH) research ^[1].

HY-135478A

LY393615 free base NCC1048 free base	Calcium Channel Sodium Channel	Neurological Disease
LY393615 (NCC1048) free base is a novel neuronal Ca ²⁺ (calcium channel) and Na ⁺ channel (sodium channel) blocker with IC₅₀s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research ^[1].

HY-B0391S1

Naftopidil-d5 KT-611-d₅; BM-15275-d₅	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-101300R

Cirazoline hydrochloride (Standard) LD 3098 hydrochloride (Standard)	Reference Standards Adenosine Receptor	Neurological Disease
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) ^[1].

HY-133214

Cyclazosin hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Cyclazosin hydrochloride is an α_1B-adrenergic receptor antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pK_i values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pK_i values of 9.23 and 9.28, respectively ^[1].

HY-B0484R

Buflomedil hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Buflomedil hydrochloride (Standard) is the analytical standard of Buflomedil hydrochloride (HY-B0484). This product is intended for research and analytical applications. Buflomedil hydrochloride (Standard), a vasodilator agent, is an orally active *α1A-adrenoceptor* antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders ^[1] .

HY-B0391R

Naftopidil (Standard) KT-611 (Standard); BM-15275 (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil (Standard) is the analytical standard of Naftopidil. This product is intended for research and analytical applications. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-B0391S2

Naftopidil-d7 KT-611-d₇; BM-15275-d₇	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-118335S

Prazobind-d8 SZL 49-d₈	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Prazobind-d₈ (SZL 49-d₈) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible *α1-adrenoceptor* antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.

HY-101390

(+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride	Calcium Channel Adrenergic Receptor	Cardiovascular Disease
(+)-Niguldipine hydrochloride is a *1,4-DHP* receptor ligand associated with L-type Ca ²⁺ channels (with K_i values of 85 pmol/L in guinea pig skeletal muscle, 140 pmol/L in brain, and 45 pmol/L in heart) as well as an α₁-adrenergic receptor ligand (with a K_i value of 78 nmol/L). (+)-Niguldipine hydrochloride shows much higher binding selectivity for *α_1α-*adrenergic receptors than for *α_1B-*adrenergic receptors. (+)-Niguldipine hydrochloride can be used in studies related to hypertension ^[1] .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5158

Conopeptide rho-TIA	Adrenergic Receptor	Others
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α_1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α_1A-Adrenergic Receptor and α_1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α₁-Adrenergic Receptor subtype-selective drugs ^[1].

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0471

Phenylephrine hydrochloride 30+ Cited Publications (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Alkaloids Monophenols Classification of Application Fields Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective *α₁-adrenoceptor* agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-B0471R

Phenylephrine hydrochloride (Standard) (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

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HY-P75544

	*A1BG/Alpha-1B-Glycoprotein Protein, Human (HEK293, His)* Alpha-1B-glycoprotein; Alpha-1-B glycoprotein; A1BG	Human	HEK293
	The A1BG/Alpha-1B-Glycoprotein protein forms a complex with CRISP3, indicating a potential functional association. This interaction prompts further exploration of its biological consequences and regulatory mechanisms. The precise roles and implications within cellular processes or physiological pathways require additional research for a comprehensive understanding. A1BG/Alpha-1B-Glycoprotein Protein, Human (HEK293, His) is the recombinant human-derived A1BG/Alpha-1B-Glycoprotein protein, expressed by HEK293 , with C-His labeled tag.

HY-P72796

	*IFN-alpha 1b/IFNA13 Protein, Human* 1 Publications Verification Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13	Human	E. coli
	IFN-alpha 1/13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response. IFN-alpha 1b/IFNA13 Protein, Human contains 166 a.a. (C24-D189, A137V), produced in E. coli cells with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 (OPC-34712-d₈-1) is the deuterium labeled Brexpiprazole (HY-15780) ^[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) .

HY-15780S

Brexpiprazole-d8

Brexpiprazole-d₈ (OPC-34712-d₈) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (K_i=0.17 nM) and α2C receptors (K_i=0.59 nM) ^.

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0391S1

Naftopidil-d5
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-B0391S2

Naftopidil-d7
Naftopidil-d₇ (KT-611-d₇ ) is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective *alpha1-adrenoceptor* antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia ^[1] .

HY-118335S

Prazobind-d8

Prazobind-d₈ (SZL 49-d₈) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.

HY-10122S

Silodosin-d4

Silodosin-d₄ is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with K_i values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH ^[1] .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4)
Application:	IHC-P (2) ICC/IF (2) WB (2) ELISA (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Phosphorylated (1) Unmodified (1)

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HY-P85024

	A1BG Antibody (YA4716) A1BG; Alpha-1B-glycoprotein; Alpha-1-B glycoprotein	IHC-P, ELISA	Human
	A1BG Antibody (YA4716) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to A1BG.

HY-P85024A

	A1BG Antibody (YA4716)(PBS only) A1BG; Alpha-1B-glycoprotein; Alpha-1-B glycoprotein	IHC-P, ELISA	Human
	A1BG Antibody (YA4716) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to A1BG.

HY-P83296

	*Phospho-alpha* Tubulin (Tyr272) Antibody (YA3041)** Tubulin alpha-1B chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain	WB, ICC/IF	Human
	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-alpha Tubulin (Tyr272).

HY-P83296A

	*Phospho-alpha* Tubulin (Tyr272) Antibody (YA3041)(PBS only)** Tubulin alpha-1B chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain	WB, ICC/IF	Human
	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-alpha Tubulin (Tyr272).