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Results for "

angioedema

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Peptides

2

Inhibitory Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126378
    LSP-249

    		Ser/Thr Protease Inflammation/Immunology
    LSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell .
    LSP-249
  • HY-16735
    Avoralstat
    4 Publications Verification

    BCX4161

    		 Ser/Thr Protease Others
    Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research .
    Avoralstat
  • HY-108814A
    Ecallantide TFA

    DX-88 TFA

    		 Kallikrein Cardiovascular Disease
    Ecallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema .
    Ecallantide TFA
  • HY-P99631
    Garadacimab
    1 Publications Verification

    CSL312

    		 Factor Xa Cardiovascular Disease
    Garadacimab (CSL312) is a first-in-class, fully human IgG4 monoclonal antibody targeting activated factor XII (FXIIa). Garadacimab has the potential for hereditary angioedema research .
    Garadacimab
  • HY-108814
    Ecallantide

    DX-88

    		 Ser/Thr Protease Cardiovascular Disease
    Ecallantide (DX-88) is a specific plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema .
    Ecallantide
  • HY-143476
    Plasma kallikrein-IN-2

    		Ser/Thr Protease Cardiovascular Disease Metabolic Disease
    Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC50 of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .
    Plasma kallikrein-IN-2
  • HY-P99110
    Lanadelumab

    SHP643; DX-2930

    		 Ser/Thr Protease Inflammation/Immunology
    Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .
    Lanadelumab
  • HY-139787
    Donidalorsen

    ISIS-721744 free acid; IONIS-PKK-LRX free acid

    		 Others Others
    Donidalorsen is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).
    Donidalorsen
  • HY-139787A
    Donidalorsen sodium

    ISIS-721744; IONIS-PKK-LRX

    		 Others Others
    Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).
    Donidalorsen sodium
  • HY-150052
    Plasma kallikrein-IN-3

    		Ser/Thr Protease Cardiovascular Disease Metabolic Disease
    Plasma kallikrein-IN-3 is a plasma kallikrein inhibitor (IC50: 0.15 μM). Plasma kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .
    Plasma kallikrein-IN-3
  • HY-114412
    TD-0212

    		Angiotensin Receptor Neprilysin Inflammation/Immunology Endocrinology
    TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP .
    TD-0212
  • HY-114412A
    TD-0212 TFA

    		Angiotensin Receptor Neprilysin Inflammation/Immunology
    TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP .
    TD-0212 TFA
  • HY-109127A
    Berotralstat dihydrochloride

    BCX7353 dihydrochloride

    		 Ser/Thr Protease Others
    Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
    Berotralstat dihydrochloride
  • HY-109127
    Berotralstat

    BCX7353

    		 Ser/Thr Protease Others
    Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
    Berotralstat

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