Search Result

Results for "

anion

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VDAC (2) 11β-HSD (1) Adrenergic Receptor (1) Akt (2) Amyloid-β (1) Antibiotic (1) Bacterial (2) Biochemical Assay Reagents (10) Chloride Channel (5) Cholinesterase (ChE) (1) Drug Metabolite (2) Elastase (1) Endogenous Metabolite (4) ERK (2) Farnesyl Transferase (1) Ferroptosis (1) Fluorescent Dye (6) Formyl Peptide Receptor (FPR) (3) Fungal (2) GLUT (2) HCV (4) HIV (2) HIV Integrase (2) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (3) MMP (1) Monoamine Oxidase (1) NO Synthase (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) RAD51 (1) Ras (1) Reactive Oxygen Species (10) SOD (1) Src (2) URAT1 (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (5) Endocrinology (1) Infection (13) Inflammation/Immunology (20) Metabolic Disease (16) Neurological Disease (8)

By Targets:

VDAC (2)

11β-HSD (1)

Adrenergic Receptor (1)

Akt (2)

Amyloid-β (1)

Antibiotic (1)

Bacterial (2)

Biochemical Assay Reagents (10)

Chloride Channel (5)

Cholinesterase (ChE) (1)

Drug Metabolite (2)

Elastase (1)

Endogenous Metabolite (4)

ERK (2)

Farnesyl Transferase (1)

Ferroptosis (1)

Fluorescent Dye (6)

Formyl Peptide Receptor (FPR) (3)

Fungal (2)

GLUT (2)

HCV (4)

HIV (2)

HIV Integrase (2)

HMG-CoA Reductase (HMGCR) (1)

Isotope-Labeled Compounds (3)

MMP (1)

Monoamine Oxidase (1)

NO Synthase (1)

p38 MAPK (1)

Parasite (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

RAD51 (1)

Ras (1)

Reactive Oxygen Species (10)

SOD (1)

Src (2)

URAT1 (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (5)

Endocrinology (1)

Infection (13)

Inflammation/Immunology (20)

Metabolic Disease (16)

Neurological Disease (8)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: VDAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W042301

Xipamide

Others Cardiovascular Disease

Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

Xipamide	Others	Cardiovascular Disease
Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-157239

*AEX HQ Anion-exchange resin*	Others	Cancer
AEX HQ Anion-exchange resin (POROS 50HQ) is AEX commonly used filler. AEX HQ Anion-exchange resin is HQ strong anion exchange resin and can purify targeting protein .

HY-157238

*AEX Anion-exchange resin 2*	Others	Others
AEX anion-exchange resin 2 is a AEX commonly used filler and is a strong anion exchange medium, Particle size: ~90μm. AEX anion-exchange resin 2 can be used in Ion exchange chromatography

HY-157236

*AEX Anion-exchange resin 1*	Others	Others
AEX Anion-exchange resin 1 is a strong anion exchange chromatography resin, based on monodisperse polystyrene/divinylbenzene (PS-DVB), with a particle size of 50 μm and an ionic ligand of –CH₂N ⁺ (CH₃)₃. AEX Anion-exchange resin 1 can be used for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

HY-N11895

Isorabaichromone	Reactive Oxygen Species	Inflammation/Immunology
Isorabaichromone is a potent antioxidant agent. Isorabaichromone shows a potent antioxidative activity and exhibits DPPH radical and superoxide anion scavenging activities .

HY-126603

Asperlactone	Others	Infection
Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .

HY-130015

HKSOX-1 (5/6-mixture) 1 Publications Verification	Reactive Oxygen Species	Others
HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Reactive Oxygen Species	Inflammation/Immunology
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-130017

HKSOX-1r (5/6-mixture)	Reactive Oxygen Species	Others
HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical .

HY-112939

Colestilan MCI-196; Colestimide	Others	Metabolic Disease
Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .

HY-N9895

3,5-Dicaffeoyl-epi-quinic acid	Others	Infection Inflammation/Immunology
3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge DPPH radical and superoxide anion radical, with IC₅₀s of 5.6 and 2.9 μg/mL respectively .

HY-121137

BMPO BocMPO	Others	Others
BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals .

HY-N9095

Curculigoside C	Others	Neurological Disease
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC₅₀ values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively .

HY-149422

NIR-FP	Fluorescent Dye	Neurological Disease
NIR-FP is a near-infrared fluorescent probe with high sensitivity and selectivity for superoxide anion O ^2-. O ^2- is the main precursor of ROS, and ferroptosis-mediated epilepsy models can be dynamically tracked by detecting O ^2-. Ferroptosis-mediated epilepsy models include: kainic acid (HY-N2309)-induced chronic epilepsy model, Pentylenetetrazole-induced acute epilepsy model, and pilocarpine (HY-B0726A)-induced epilepsy model .

HY-121693

DIDS	RAD51	Cancer
DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane .

HY-125792

Nexinhib20	Reactive Oxygen Species Ras	Inflammation/Immunology
Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC₅₀ of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity .

HY-154912

PAT1inh-B01	Others	Inflammation/Immunology
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders .

HY-154912A

PAT1inh-B01 hydrochloride	Others	Inflammation/Immunology
PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl ^-/HCO3 ^- exchanger)-mediated anion exchange (IC₅₀: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders .

HY-122009

Indican Indoxyl-β-D-glucoside	Fluorescent Dye	Others
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-D0876

POPSO	Biochemical Assay Reagents	Others
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC₅₀ value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .

HY-103703

DEAE Cross-linked dextran A 25

Others Others

DEAE Cross-linked dextran A 25 is a weak anion exchanger .
HY-142655

Ftase inhibitor III

Farnesyl Transferase Infection

Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen.

DEAE Cross-linked dextran A 25	Others	Others
DEAE Cross-linked dextran A 25 is a weak anion exchanger .

Ftase inhibitor III	Farnesyl Transferase	Infection
Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen.

HY-148682

18β-Glycyrrhetyl-3-O-sulfate Glycyrrhetic acid 3-O-hydrogen sulfate	11β-HSD Drug Metabolite	Metabolic Disease Inflammation/Immunology
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC₅₀ of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research .

HY-137148

DIOA

Others Cancer

DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist .
HY-N8217

4-O-Cinnamoylquinic acid

Others Inflammation/Immunology

4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

DIOA	Others	Cancer
DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist .

4-O-Cinnamoylquinic acid	Others	Inflammation/Immunology
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-U00005

AD 0261	Reactive Oxygen Species	Inflammation/Immunology
AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.

HY-N2183

Baimaside

Quercetin 3-O-sophoroside

Baimaside (Quercetin 3-O-sophoroside) is isolated from the flowers of A. venetum, is a scavenger of superoxide anions .

Baimaside Quercetin 3-O-sophoroside
Baimaside (Quercetin 3-O-sophoroside) is isolated from the flowers of A. venetum, is a scavenger of superoxide anions .

HY-141490

Beta-D-Glucopyranosyl nitromethane	Others	Others
Beta-D-Glucopyranosyl nitromethane, as a salt of a strongly basic anion exchanger in the OH cycle, is a glycosyl derivative of nitromethane .

HY-W155121

Big CHAP

N,N-Bis(3-D-gluconamidopropyl)cholamide
Biochemical Assay Reagents Others

Big CHAP are aqueous micelles of anionic cholate analogues .
HY-100244

NS1652

Chloride Channel Neurological Disease

NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC₅₀ of 1.6 μM in human and mouse red blood cells.

Big CHAP N,N-Bis(3-D-gluconamidopropyl)cholamide	Biochemical Assay Reagents	Others
Big CHAP are aqueous micelles of anionic cholate analogues .

NS1652	Chloride Channel	Neurological Disease
NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC₅₀ of 1.6 μM in human and mouse red blood cells.

HY-W127701

[Bmpip][NTf2] 1-Butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide	Biochemical Assay Reagents	Others
[Bmpip][NTf2] is composed of 1-butyl-1-methylimidazolium cation and bis(trifluoromethylsulfonyl)imide anion.

HY-156468

Antioxidant agent-17

Others Inflammation/Immunology

Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM .

Antioxidant agent-17	Others	Inflammation/Immunology
Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM .

HY-N1579

Pyrogallol 2 Publications Verification
Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.

HY-D0217

Sulfobromophthalein disodium salt 3 Publications Verification Bromosulfophthalein disodium salt	Fluorescent Dye	Metabolic Disease
Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites .

HY-109987

ISPA-28

Parasite Infection

ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3 .

ISPA-28	Parasite	Infection
ISPA-28 is a specific *plasmodial surface anion* channel (PSAC)** antagonist. ISPA-28 binds directly and reversibly to CLAG3 .

HY-N11564

Aristololactam IIIa	Elastase	Inflammation/Immunology
Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively .

HY-N9447

Norbergenin 1 Publications Verification	Reactive Oxygen Species	Neurological Disease
Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC₅₀ 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .

HY-N8447

3'-O-Methylmurraol	Others	Others
3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .

HY-100322

H100	Chloride Channel	Cardiovascular Disease
H100 is a Cl ^- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes.

HY-149276

SLC26A3-IN-2	GLUT	Metabolic Disease
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC₅₀=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .

HY-149802

SLC26A3-IN-1	GLUT	Metabolic Disease
SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC₅₀=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea .

HY-105917

Emidurdar 2 Publications Verification Endovion; NS3728	Chloride Channel	Others
Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor .

HY-W011819

Tetradecanedioic acid	Endogenous Metabolite	Metabolic Disease
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions .

HY-N4096

Tsugaric acid A	Others	Inflammation/Immunology
Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.

HY-138142

Euphol acetate	Others	Metabolic Disease
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins *organic anion-transporting polypeptide 1/3 (OATP1B1/3)* .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Endogenous Metabolite	Metabolic Disease Endocrinology
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-N2412

Irisolidone	Chloride Channel	Neurological Disease Cancer
Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for *volume-regulated anion* channels (VRAC)** blockade (IC₅₀=9.8 μM) .

HY-N3464

Isopedicin	Phosphodiesterase (PDE)	Metabolic Disease
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .

HY-153540

AP-C4	Others	Others
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .

HY-129122

VBIT-4 5+ Cited Publications	VDAC	Cardiovascular Disease Neurological Disease
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (K_d) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases .

Cat. No.	Product Name	Type

HY-130015

HKSOX-1 (5/6-mixture) 1 Publications Verification	Fluorescent Dyes/Probes
HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical .

HY-130017

HKSOX-1r (5/6-mixture)	Fluorescent Dyes/Probes
HKSOX-1r (5/6-mixture) is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1r (5/6-mixture) exhibits excellent selectivity and sensitivity towards superoxide anion radical .

HY-D0217

Sulfobromophthalein disodium salt 3 Publications Verification Bromosulfophthalein disodium salt	Dyes
Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites .

HY-D0720

Lucigenin 4 Publications Verification NSC-151912; L-6868	Fluorescent Dyes/Probes
Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O ^2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .

HY-18743

Coelenterazine

2 Publications Verification

Fluorescent Dyes/Probes

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-W010947

4-Methylumbelliferyl palmitate

Fluorescent Dyes/Probes

4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. 4-Methylumbelliferyl palmitate exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exist mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions .

Cat. No.	Product Name	Type

HY-D0876

POPSO	Biochemical Assay Reagents
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC₅₀ value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .

HY-W127701

[Bmpip][NTf2] 1-Butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide	Biochemical Assay Reagents
[Bmpip][NTf2] is composed of 1-butyl-1-methylimidazolium cation and bis(trifluoromethylsulfonyl)imide anion.

HY-W011052

Tetrapentylammonium bromide

Biochemical Assay Reagents

Tetrapentylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetrapentylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic synthesis reactions to facilitate the transfer of reactants between immiscible phases. It is also used in the production of surfactants, detergents and the synthesis of pharmaceuticals.

HY-W011087

Benzyldimethyltetradecylammonium chloride

Biochemical Assay Reagents

Benzyldimethyltetradecylammonium chloride is a quaternary ammonium salt consisting of a positively charged N-benzyl-N,N-dimethyltetradecyl-1-amine cation and a negatively charged chloride anion. The compound is commonly used as a surfactant and emulsifier in a variety of applications including detergents, fabric softeners and personal care products. It also has antimicrobial properties and is used as a disinfectant or antiseptic in some products.

HY-W155121

Big CHAP

N,N-Bis(3-D-gluconamidopropyl)cholamide
Surfactants

Big CHAP are aqueous micelles of anionic cholate analogues .

HY-W014408

Tetraethylammonium bromide

TEA bromide

Biochemical Assay Reagents

Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.

HY-W127790

Bathophenanthrolinedisulfonic acid disodium

Biochemical Assay Reagents

Bathophenanthrolinedisulfonic acid disodium salt is used as a colorimetric reagent for the detection of iron. It is widely used for the determination of iron in aqueous solutions without the use of extraction solvents. It is used as a precursor for the preparation of the anion Europium(III) disulfonated bathophenanthroline tris(dibenzoylformic acid) complex and ruthenium II tris(rubphenanthroline disulfonate). It plays a crucial role in the catalytic oxidation of 2-hexanol by enabling it to form a water-soluble complex with palladium.

HY-W011972

Bromocholine bromide

Biochemical Assay Reagents

2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.

HY-W013231

N-Benzyl-N,N-diethylethanaminium iodide

Benzyltriethylammonium iodide

Biochemical Assay Reagents

N-Benzyl-N,N-diethylethanaminium iodide is a quaternary ammonium salt consisting of a positively charged N-benzyl-N,N-diethylethylamine cation and a negatively charged iodide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, and as a surfactant or emulsifier in industrial and personal care products.

HY-W018574

Tetraoctylammonium bromide

Biochemical Assay Reagents

Tetraoctylammonium bromide (TOAB) is a quaternary ammonium salt consisting of a positively charged tetraoctylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It is also used as a surfactant and dispersant in various industrial applications, for example in the production of coatings, adhesives and polymers. Additionally, Tetraoctylammonium bromide has been investigated for potential applications in energy storage devices and as an antimicrobial agent.

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Alkaloids Simaroubaceae Source classification Plants Picrasma quassioides(D．Don)Benn． Indole Alkaloids	Reactive Oxygen Species
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-N9895

3,5-Dicaffeoyl-epi-quinic acid	Structural Classification Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae	Others
3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge DPPH radical and superoxide anion radical, with IC₅₀s of 5.6 and 2.9 μg/mL respectively .

HY-122009

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	Fluorescent Dye
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-N11895

Isorabaichromone	Structural Classification Liliaceae Simple Phenylpropanols Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Phenylpropanoids Plants	Reactive Oxygen Species
Isorabaichromone is a potent antioxidant agent. Isorabaichromone shows a potent antioxidative activity and exhibits DPPH radical and superoxide anion scavenging activities .

HY-N9095

Curculigoside C	Curculigo orchioides Gaertn. Structural Classification Source classification Phenols Polyphenols Plants Amaryllidaceae	Others
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC₅₀ values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively .

HY-N8217

4-O-Cinnamoylquinic acid	Structural Classification Viscum Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields Loranthaceae	Others
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-N11564

Aristololactam IIIa	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Aristolochia manshuriensis Kom Plants Aristolochiaceae	Elastase
Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively .

HY-N9447

Norbergenin 1 Publications Verification	Natural Products other families Source classification Phenols Polyphenols Plants	Reactive Oxygen Species
Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC₅₀ 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .

HY-N8447

3'-O-Methylmurraol	Structural Classification Scutellaria ovata Hill Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Others
3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .

HY-W011819

Tetradecanedioic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions .

HY-N4096

Tsugaric acid A	Triterpenes Structural Classification Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.

HY-138142

Euphol acetate	Triterpenes other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins *organic anion-transporting polypeptide 1/3 (OATP1B1/3)* .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .

HY-N2412

Irisolidone	Flavonoids Neurological Disease Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Pueraria lobata (Willd.) Ohwi var. montana (Lour.)van der Maesen Disease Research Fields Isoflavones Cancer	Chloride Channel
Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for *volume-regulated anion* channels (VRAC)** blockade (IC₅₀=9.8 μM) .

HY-N3464

Isopedicin	Structural Classification Flavonoids Flavonones Source classification Plants Annonaceae Fissistigma oldhamii (Hemsl.) Merr.	Phosphodiesterase (PDE)
Isopedicin potently and concentration-dependently inhibits superoxide anion (O2 U?) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. Isopedicin increases cAMP formation and PKA activity in FMLP-activated cells by inhibiting phosphodiesterase (PDE) activity .

HY-N3513

Mulberrin 3 Publications Verification Kuwanon C	Cardiovascular Disease Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields	Others
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8 ±1.5 μM.

HY-18743

Coelenterazine 2 Publications Verification	Alkaloids Structural Classification Monophenols Classification of Application Fields Animals Source classification Phenols Polyphenols Disease Research Fields Cancer	Reactive Oxygen Species
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Natural Products Polygonum chinense Linn. Polygonaceae Source classification Plants	Others
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-156241

Meliadubin B	Melia dubia Cav. Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae	NO Synthase Fungal
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC₅₀ of 182.50 μM.

HY-W001189

1,3-Dithiane	Infection Natural Products Classification of Application Fields Animals Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite
1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon . 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100 .

HY-N9295

3,4-Seco-4(23),20(29)-lupadiene-3,28-dioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Lithocarpus litseifolius (Hance) Chun Plants Fagaceae	Others
3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid (Compound 5) is a triterpenoid compound. 3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid has a strong inhibitory effect on the production of superoxide anions, and the inhibitory rate is 86.9±2.8% at 1 μM .

HY-N12007

OAT1/3-IN-1	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Others
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Others
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Structural Classification Natural Products Pinaceae Source classification Plants	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Species:	Human (3)
Tag:	GFP (1) His (3) Strep (2) MBP (1) Flag (2)
Source:	HEK293 (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702019

	SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) SLCO1A2; Solute carrier organic anion transporter family member 1A2; OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3	Human	Sf9 insect cells
	SLC21A3 is a Na(+)-independent transporter that greatly facilitates cellular uptake of a variety of organic anions, including bile salts necessary for intestinal absorption. SLC21A3 is responsible for transporting substances such as DHEAS, estrone 3-sulfate, and atROL in human retinal pigment epithelial cells to maintain the integrity of the visual cycle. SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC21A3 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC21A3 Protein, Human (Sf9, His, MBP, FLAG) is 669 a.a., .

HY-P702011

	SLC22A6 Protein, Human (Sf9, His, Strep, FLAG) SLC22A6; Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1	Human	Sf9 insect cells
	The SLC22A6 protein acts as a Na(+)-independent organic anion (OA)/dicarboxylic acid antiporter and promotes renal elimination by transporting OA from proximal tubule cells into the urine. It transports coenzymes (BH4, BH2, septopterin) and determines blood biopterin levels as well as prostaglandins, cyclic nucleotides, tryptophan metabolites, uremic toxins (e.g. indoxyl sulfate) and xenobiotics (e.g. ochratoxin). SLC22A6 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived SLC22A6 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of SLC22A6 Protein, Human (Sf9, His, Strep, FLAG) is 562 a.a., .

HY-P701354

	ABCC4 Protein, Human (HEK293, GFP, Strep, His) ABCC4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; Multidrug resistance-associated protein 4	Human	HEK293
	ABCC4 Protein, an ATP-binding cassette (ABC) family member, actively transports endogenous compounds (cAMP, cGMP, bile acids) and xenobiotics from cells. Its versatility extends to glutathione conjugates (LTC4, LTB4) and drug metabolites, mediating cotransport of bile acids with reduced glutathione. ABCC4's function includes resistance to anticancer agents like methotrexate, highlighting its role in cellular communication and drug transport. ABCC4 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived ABCC4 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of ABCC4 Protein, Human (HEK293, GFP, Strep, His) is 1325 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-125348S

6α-Hydroxy Paclitaxel-d5

6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].

HY-W011819S

Tetradecanedioic acid-d24
Tetradecanedioic acid-d₂₄ is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].

HY-10466S

Daclatasvir-d6
Daclatasvir-d₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-10466S2

Daclatasvir-d16
Daclatasvir-d₁₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

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