Search Result
Results for "
anti inflammatory
" in MCE Product Catalog:
1509
Inhibitors & Agonists
2
Biochemical Assay Reagents
193
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-146547
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Anti-inflammatory agent 17
|
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Inflammation/Immunology
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Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).
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- HY-147769
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Anti-inflammatory agent 23
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 23 (Compound 4m) is an anti-inflammatory agent. Anti-inflammatory agent 23 inhibits the production of NO activated by LPS with an IC50 of 0.449 μM. Anti-inflammatory agent 23 has a good affinity for p65 protein.
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- HY-146435
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Anti-inflammatory agent 22
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TNF Receptor
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Inflammation/Immunology
|
Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice.
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- HY-N10436
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- HY-N10435
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- HY-N10434
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- HY-143410
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-
- HY-146421
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Anti-inflammatory agent 21
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NO Synthase
NF-κB
Reactive Oxygen Species
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Inflammation/Immunology
|
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.
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- HY-145869
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Anti-inflammatory agent 12
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC50 value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease.
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- HY-U00273
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-
- HY-146419
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Anti-inflammatory agent 20
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NF-κB
COX
TNF Receptor
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Inflammation/Immunology
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Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation.
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- HY-145870
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Anti-inflammatory agent 13
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation.
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- HY-115922
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Anti-inflammatory agent 10
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COX
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Inflammation/Immunology
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Anti-inflammatory agent 10 (compound 30) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 10 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 10 is orally active.
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- HY-115921
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Anti-inflammatory agent 9
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COX
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Inflammation/Immunology
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Anti-inflammatory agent 9 (compound 28) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 9 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 9 is orally active.
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- HY-144737
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Anti-inflammatory agent 15
|
Bacterial
TNF Receptor
|
Infection
Inflammation/Immunology
|
Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.
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- HY-144727
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Anti-inflammatory agent 11
|
Bacterial
TNF Receptor
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Infection
Inflammation/Immunology
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Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research.
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- HY-150587
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Anti-inflammatory agent 31
|
ERK
NF-κB
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Inflammation/Immunology
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Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.
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- HY-115920
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Anti-inflammatory agent 8
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COX
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Inflammation/Immunology
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Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active.
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- HY-144735
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-
- HY-143456
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Anti-inflammatory agent 18
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
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- HY-143457
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Anti-inflammatory agent 19
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
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- HY-139833
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- HY-N10066
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-
- HY-139844
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- HY-N3977
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- HY-17361
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Etofenamate
|
COX
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Inflammation/Immunology
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Etofenamate, a non-steroid anti-inflammatory drug (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
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- HY-N2302
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- HY-N9312
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- HY-105939
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Isofezolac
LM 22070
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PGE synthase
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Inflammation/Immunology
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Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties.
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- HY-N7700
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- HY-17361S
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Etofenamate-d4
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COX
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Inflammation/Immunology
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Etofenamate-d4 is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory drug (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
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- HY-B1137
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Ramifenazone
Isopropylaminoantipyrine
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Others
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Inflammation/Immunology
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Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities.
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- HY-N2604
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- HY-B0174
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- HY-N5116
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- HY-N0741A
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- HY-N0741
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- HY-N0474
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- HY-106628
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Sudoxicam
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COX
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Inflammation/Immunology
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Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.
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- HY-116015
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-
- HY-B0634
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Aceclofenac
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COX
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Inflammation/Immunology
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Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
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- HY-B2113
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- HY-101751
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-
- HY-U00081
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-
- HY-N0181
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- HY-N0570
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-
- HY-N2393
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-
- HY-N0007
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- HY-N9451
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- HY-N8197
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- HY-N9400
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- HY-144773A
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- HY-W015820
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Phthalide
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Others
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Inflammation/Immunology
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Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant.
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- HY-B1203
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-
- HY-100286
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- HY-U00100
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-
- HY-100146
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- HY-111392
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-
- HY-B1047
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-
- HY-107831
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-
- HY-101655
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COX-2-IN-2
|
COX
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Inflammation/Immunology
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COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
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- HY-119684
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Maresin 2
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Others
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Inflammation/Immunology
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Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages.
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- HY-N0101
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- HY-N2542
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- HY-B0729
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Polaprezinc
Zinc L-carnosine
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Others
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Inflammation/Immunology
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Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
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- HY-N0452
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-
- HY-N6656
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-
- HY-W050088
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Isoxepac
HP 549
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Others
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Inflammation/Immunology
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Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc.
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- HY-17476
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- HY-B0288B
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- HY-N2988A
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- HY-109098
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- HY-B0288A
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- HY-N10276
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- HY-14937
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- HY-N3587
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- HY-103385
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NCX4040
NO-Aspirin
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Apoptosis
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Cancer
Inflammation/Immunology
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NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects.
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- HY-N0783
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- HY-N6039
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- HY-N0423
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- HY-N2437
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- HY-N0370
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- HY-B1214
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- HY-106579
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Tiaprofenic acid
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COX
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Inflammation/Immunology
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Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.
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- HY-N1954
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Protostemonine
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Others
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Inflammation/Immunology
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Protostemonine is an active alkaloid mainly isolated from the roots of Stemona sesslifolia, with anti-inflammatory activity. Protostemonine has anti-inflammatory effects on asthma and gram-negative bacteria-induced acute lung injury.
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- HY-N10114
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- HY-17485
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Alminoprofen
EB-382
|
Phospholipase
COX
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Inflammation/Immunology
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Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
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- HY-N0474S
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- HY-N1965
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Gaultherin
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Others
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Inflammation/Immunology
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Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin.
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- HY-128695
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- HY-13571
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- HY-U00350
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- HY-N0213
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- HY-W011954
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- HY-B0645
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- HY-U00043
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- HY-B1383
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- HY-N2030
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- HY-N2035
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- HY-N7083
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- HY-104015
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- HY-N0362
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- HY-N5010
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- HY-N9388
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-
- HY-U00063
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- HY-111950
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(-)-Ibuprofenamide
(R)-Ibuprofenamide
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Others
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Inflammation/Immunology
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(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
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- HY-B0634S
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Aceclofenac-d4
|
COX
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Inflammation/Immunology
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Aceclofenac-d4 is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
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- HY-17463
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Prednisolone
|
Glucocorticoid Receptor
Endogenous Metabolite
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Endocrinology
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Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
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- HY-N4137
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-
- HY-N0628
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-
- HY-N0184A
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-
- HY-N0180
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-
- HY-N8091
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Lehmannine
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Bacterial
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Cancer
Infection
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Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities.
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- HY-N0875
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-
- HY-N4312
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-
- HY-W173309
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-
- HY-B0248
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-
- HY-N0725
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-
- HY-B1900
-
-
- HY-W013332
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-
- HY-W013332A
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-
- HY-101737
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-
- HY-N0820
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-
- HY-N2555
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-
- HY-N7937
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-
- HY-N0472
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-
- HY-N0114
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Evodiamine
(+)-Evodiamine; d-Evodiamine
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Others
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Cancer
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Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
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- HY-N0512
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Loganin
Loganoside
|
Apoptosis
|
Cancer
|
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.
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- HY-15097
-
-
- HY-N0400
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-
- HY-N0271
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-
- HY-17492
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-
- HY-107470
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-
- HY-N0344
-
-
- HY-N0212
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Peimine
Verticine; Dihydroisoimperialine
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Others
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Inflammation/Immunology
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Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
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- HY-103672
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-
- HY-N6941
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-
- HY-N2123
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-
- HY-U00169
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-
- HY-B0270
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-
- HY-N0763
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Angelicin
Isopsoralen
|
Apoptosis
Virus Protease
|
Cancer
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Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.
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- HY-N0924
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(±)-Stylopine
Tetrahydrocoptisine
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Others
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Inflammation/Immunology
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(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.
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- HY-N0924A
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-
- HY-N0126
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-
- HY-B0619
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Zaltoprofen
CN100
|
COX
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Inflammation/Immunology
|
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
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- HY-N0055
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Chlorogenic acid
3-O-Caffeoylquinic acid; Heriguard; NSC-407296
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Bacterial
Influenza Virus
Endogenous Metabolite
|
Cancer
Infection
Inflammation/Immunology
|
Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
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- HY-10529
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-
- HY-N4226
-
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
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Others
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Inflammation/Immunology
Cancer
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.
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- HY-N0408
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Picroside II
|
NF-κB
Reactive Oxygen Species
Apoptosis
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities.
picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways.
Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
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- HY-100977
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-
- HY-N0559
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-
- HY-P1539
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-
- HY-N0056
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-
- HY-N3472
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-
- HY-17484
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-
- HY-B1013
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-
- HY-N10210
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-
- HY-N0813
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-
- HY-14579
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-
- HY-N2352A
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-
- HY-N2271
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-
- HY-136203
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-
- HY-B0289
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-
- HY-136204
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-
- HY-B2114
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Escin
|
Apoptosis
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Inflammation/Immunology
Cancer
|
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
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- HY-N5025
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Bullatine A
|
P2X Receptor
Apoptosis
|
Cancer
Inflammation/Immunology
|
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.
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- HY-N2083
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Handelin
|
NF-κB
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Inflammation/Immunology
|
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production.
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- HY-B1893
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-
- HY-N0748
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-
- HY-P1009
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Z-YVAD-FMK
|
Caspase
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Cancer
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Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities.
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- HY-N6244
-
Isolindleyin
|
Tyrosinase
|
Inflammation/Immunology
|
Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.
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- HY-N3408
-
Lamiide
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Others
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Inflammation/Immunology
|
Lamiide, an orally active iridoid compound, can be found in Bouchea fluminensis leaves. Lamiide exhibits anti-inflammatory and anti-lipoperoxidative activity.
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- HY-N0250
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-
- HY-N3845
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Ergosterol peroxide
|
Bacterial
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Cancer
Inflammation/Immunology
|
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities.
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- HY-N6980
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Licorice glycoside C2
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Others
|
Cancer
Infection
|
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects.
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- HY-N2014
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Verbenalin
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
Verbenalin is Verbena glycoside, with anti-inflammatory, anti-fungal anti-virus activities. Verbenalin can be used for the research of prostatitis. Verbenalin can reduce cerebral ischemia-reperfusion injury.
|
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- HY-N6806
-
-
- HY-N0222
-
-
- HY-105008
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Secoisolariciresinol diglucoside
(S,S)-SDG; (S,S)-LGM2605
|
Others
|
Inflammation/Immunology
Neurological Disease
Cardiovascular Disease
|
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.
|
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- HY-132607
-
-
- HY-N4068
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Glucoraphanin
|
Reactive Oxygen Species
|
Cancer
|
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.
|
-
- HY-D0803
-
Thymoquinone
|
Others
|
Inflammation/Immunology
|
Thymoquinone is a nature product isolated from N. sativa. Thymoquinone possess antioxidant, anti-inflammatory, anti-cancer, antitumor activities and hepatoprotective properties.
|
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- HY-N2423
-
-
- HY-N5089
-
-
- HY-N0207
-
-
- HY-N0558
-
Alnustone
|
Others
|
Inflammation/Immunology
|
Alnustone, a non-phenolic diarylheptanoid found in herbs and spices, is a constituent of Curcuma xanthorrhiza. Alnustone displays anti-emetic and anti-inflammatory activities.
|
-
- HY-136718
-
CLEFMA
|
Apoptosis
|
Cancer
|
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
|
-
- HY-N6246
-
Asperulosidic Acid
|
NF-κB
ERK
|
Cancer
Inflammation/Immunology
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities.
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
|
-
- HY-17463S
-
Prednisolone-d8
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Endocrinology
|
Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
|
-
- HY-B0482
-
Acemetacin
TVX 1322
|
COX
|
Inflammation/Immunology
|
Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-N2516
-
-
- HY-17481
-
-
- HY-B1179
-
-
- HY-N8534
-
-
- HY-B0641
-
-
- HY-122267A
-
-
- HY-14857
-
-
- HY-N2854
-
-
- HY-B1104
-
-
- HY-108281
-
-
- HY-107208
-
-
- HY-N10120
-
-
- HY-N2151
-
-
- HY-111354
-
-
- HY-101581
-
Bucloxic acid
804CB; Bucloxonic acid; Esfar
|
Others
|
Inflammation/Immunology
|
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
|
-
- HY-14916
-
-
- HY-U00048
-
-
- HY-N2152
-
-
- HY-N2154
-
-
- HY-32343
-
-
- HY-B0386
-
-
- HY-N1451
-
-
- HY-129060
-
Flutrimazole
|
Fungal
|
Infection
|
Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
|
-
- HY-120824
-
Mofezolac
|
COX
|
Inflammation/Immunology
|
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities.
|
-
- HY-19384
-
Enflicoxib
E 6087
|
COX
|
Inflammation/Immunology
|
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.
|
-
- HY-N5003
-
-
- HY-N0575
-
-
- HY-W013573
-
-
- HY-17482
-
Difenpiramide
Z-876
|
Others
|
Inflammation/Immunology
|
Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity.
|
-
- HY-N0370S
-
Bergapten-d3
5-Methoxypsoralen-d3
|
Cytochrome P450
Autophagy
|
Cancer
|
Bergapten-d3 is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
|
-
- HY-N9615
-
-
- HY-N7292
-
-
- HY-N2807
-
-
- HY-P1539A
-
-
- HY-W013075
-
Rutin trihydrate
Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate
|
Others
|
Neurological Disease
|
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .
|
-
- HY-N2490
-
-
- HY-N1402
-
Oxysophoridine
Sophoridine N-oxide
|
Apoptosis
|
Inflammation/Immunology
|
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects.
|
-
- HY-B0619S
-
Zaltoprofen-d7
|
COX
|
Inflammation/Immunology
|
Zaltoprofen-d7 is the deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-B1079
-
-
- HY-N8038
-
Isoanthricin
(Rac)-Deoxypodophyllotoxin
|
Others
|
Others
|
Isoanthricin ((Rac)-Deoxypodophyllotoxin) is the racemate of Deoxypodophyllotoxin. Deoxypodophyllotoxin is a potent antitumor and anti-inflammatory agent.
|
-
- HY-N10112
-
-
- HY-N8149
-
-
- HY-N0272
-
-
- HY-B0485
-
-
- HY-150002
-
-
- HY-B1203S1
-
Fludrocortisone-d2
9α-Fludrocortisone-d2; 9α-Fluorcortisol-d2
|
Mineralocorticoid Receptor
|
|
Fludrocortisone-d2 is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.
|
-
- HY-N4290
-
-
- HY-N6804
-
-
- HY-N3125
-
-
- HY-N0662
-
-
- HY-W173220
-
-
- HY-B0878
-
Halobetasol (propionate)
BMY-30056; CGP-14458; Ulobetasol propionate
|
Others
|
Others
|
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.
|
-
- HY-N9375
-
-
- HY-N7976
-
-
- HY-N2052
-
-
- HY-N6948
-
-
- HY-N7903
-
-
- HY-N2590
-
Lupenone
|
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
Lupenone, isolated from Rhizoma Musae, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity.
|
-
- HY-N4322
-
-
- HY-12840
-
-
- HY-N0401
-
-
- HY-N0770
-
Isoliensinine
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells.
|
-
- HY-N0064
-
-
- HY-N2357
-
-
- HY-145854
-
GA-O-06
|
Bacterial
|
Infection
Inflammation/Immunology
|
GA-O-06, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-06 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-06 displays a high antimicrobial activity against Gram-positive bacteria.
|
-
- HY-N2855
-
Alphitolic acid
Aophitolic acid
|
Apoptosis
Autophagy
TNF Receptor
Akt
NF-κB
|
Cancer
Inflammation/Immunology
|
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.
|
-
- HY-145853
-
GA-O-02
|
Bacterial
|
Infection
Inflammation/Immunology
|
GA-O-02, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-02 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-02 displays a high antimicrobial activity against Gram-positive bacteria.
|
-
- HY-N0570S1
-
-
- HY-N0570S
-
-
- HY-N0393
-
Glabridin
|
PPAR
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
|
-
- HY-23119
-
-
- HY-N0013
-
-
- HY-N0759
-
-
- HY-B0494
-
-
- HY-N3017
-
-
- HY-Y1362
-
-
- HY-N6827
-
-
- HY-N2965
-
-
- HY-17509
-
-
- HY-76225
-
Ammonium glycyrrhizinate
Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate
|
Others
|
Inflammation/Immunology
|
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
|
-
- HY-N2441
-
-
- HY-N0228
-
-
- HY-131118
-
-
- HY-125131
-
-
- HY-147247
-
-
- HY-121235
-
-
- HY-101482
-
-
- HY-N0779A
-
Silybin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
|
-
- HY-N0804
-
Narirutin
|
Bacterial
|
Inflammation/Immunology
|
Narirutin, one of the active constituents isolated from Citrus unshiu, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency.
|
-
- HY-N1181
-
-
- HY-N5086
-
-
- HY-126562
-
-
- HY-N6258
-
Kahweol
|
AMPK
Apoptosis
|
Metabolic Disease
|
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
|
-
- HY-Y0892
-
-
- HY-N1388
-
Tussilagone
|
Others
|
Inflammation/Immunology
|
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.
|
-
- HY-144237
-
BRP-201
|
PGE synthase
|
Inflammation/Immunology
|
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the treatment of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
|
-
- HY-N2905
-
Aurantiamide acetate
Asperglaucide
|
Cathepsin
|
Inflammation/Immunology
|
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.
|
-
- HY-Y0189
-
Methyl Salicylate
Wintergreen oil
|
COX
|
Inflammation/Immunology
|
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor.
|
-
- HY-17485S
-
Alminoprofen-d3
EB-382-d3
|
Phospholipase
COX
|
Inflammation/Immunology
|
Alminoprofen-d3 (EB-382-d3) is the deuterium labeled Alminoprofen. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
|
-
- HY-N0313
-
Euphol
|
Endogenous Metabolite
MAGL
|
Inflammation/Immunology
|
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain.
|
-
- HY-B0619S1
-
Zaltoprofen-13C,d3
|
COX
|
Inflammation/Immunology
|
Zaltoprofen-13C,d3 is the 13C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-147105
-
LRH-1 modulator-1
|
Others
|
Inflammation/Immunology
|
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa.
|
-
- HY-N3848
-
-
- HY-Y0073
-
4-Hydroxyacetophenone
P-hydroxyacetophenone
|
HBV
|
Infection
Inflammation/Immunology
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect.
|
-
- HY-N6049
-
-
- HY-N0363
-
(+)-Columbianetin
(S)-Columbianetin
|
Others
|
Infection
Inflammation/Immunology
|
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-N0007S
-
Bisdemethoxycurcumin-d8
Curcumin III-d8; Didemethoxycurcumin-d8
|
Apoptosis
Autophagy
|
Cancer
|
Bisdemethoxycurcumin-d8 (Curcumin III-d8) is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
|
-
- HY-N2281
-
-
- HY-125938
-
Cycloartenyl ferulate
Cycloartenol ferulate; Cycloartenol ferulic acid ester
|
Others
|
Cancer
Inflammation/Immunology
|
Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities.
|
-
- HY-10448
-
-
- HY-N0639
-
Punicalin
|
HBV
|
Infection
Inflammation/Immunology
|
Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity.
|
-
- HY-N7044
-
-
- HY-147404
-
-
- HY-N1981
-
-
- HY-N9834
-
-
- HY-N0719
-
-
- HY-B0625
-
-
- HY-N2114
-
-
- HY-13075
-
-
- HY-N1089
-
-
- HY-119517
-
-
- HY-14398
-
-
- HY-N0576
-
-
- HY-130046
-
-
- HY-B0367
-
-
- HY-B1832
-
-
- HY-N3544
-
-
- HY-101481
-
-
- HY-14938
-
-
- HY-P1572
-
-
- HY-104025
-
-
- HY-17629
-
-
- HY-144238
-
mPGES-1-IN-1
|
Others
|
Inflammation/Immunology
|
MPGES-1 is considered as a promising therapeutic target of the next generation anti-inflammatory drugs in the treatment of inflammatory diseases. The < b > IC < sub > 50 < / sub > < / b > value of mPGES-1-IN-1 is 0.03 μ M。
|
-
- HY-N6961
-
Lapachol
|
Bacterial
Fungal
Influenza Virus
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae). Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities.
|
-
- HY-N1377
-
Nevadensin
|
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
|
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.
|
-
- HY-N0363A
-
(+)-Columbianetin acetate
(S)-Columbianetin acetate
|
Others
|
Infection
Inflammation/Immunology
|
(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-105028
-
Tenidap
CP-66248
|
COX
|
Inflammation/Immunology
|
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-N0831
-
Jaceosidin
|
Bcl-2 Family
COX
Apoptosis
|
Cancer
Inflammation/Immunology
|
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.
|
-
- HY-P2320
-
IDR-1
|
Bacterial
|
Infection
Inflammation/Immunology
|
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release.
|
-
- HY-N6884
-
-
- HY-32736
-
Triptonide
NSC 165677; PG 492
|
Wnt
β-catenin
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
|
-
- HY-133159
-
-
- HY-114771
-
-
- HY-N4146
-
-
- HY-N0516
-
Casticin
Vitexicarpin
|
STAT
|
Inflammation/Immunology
|
Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
|
-
- HY-N2263
-
Skimmin
Umbelliferone glucoside
|
Others
|
Inflammation/Immunology
|
Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity.
|
-
- HY-N2012
-
-
- HY-W008613
-
-
- HY-W013331
-
-
- HY-N1178
-
-
- HY-U00187
-
NCX1022
|
Others
|
Inflammation/Immunology
|
NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory drug for the treatment of skin inflammation.
|
-
- HY-B1153A
-
-
- HY-N2053
-
Physalin L
|
NO Synthase
|
|
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity.
|
-
- HY-122915
-
-
- HY-139709
-
-
- HY-109082A
-
-
- HY-N2401
-
-
- HY-120007
-
-
- HY-139710
-
-
- HY-N5022
-
Evolitrine
7-Methoxydictamnine; Evolitrin
|
Others
|
Inflammation/Immunology
|
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities.
|
-
- HY-109082
-
-
- HY-N1625
-
-
- HY-12384
-
Tenosal
|
Others
|
Inflammation/Immunology
|
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-U00022
-
-
- HY-105808
-
-
- HY-N0246
-
-
- HY-N2842
-
-
- HY-N9694
-
-
- HY-N7176
-
Kaempferol 3-O-β-D-glucuronide
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Inflammation/Immunology
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.
|
-
- HY-16126
-
-
- HY-N0773
-
Isovitexin
Saponaretin; Homovitexin
|
JNK
NF-κB
|
Inflammation/Immunology
|
Isovitexin is a flavonoid isolated from rice hulls of Oryza sativa, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.
|
-
- HY-109011
-
Rosiptor
AQX-1125
|
Phosphatase
|
Cancer
|
Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
|
-
- HY-N8435
-
-
- HY-119500
-
-
- HY-N0889
-
Ginkgetin
|
Wnt
Apoptosis
Autophagy
|
Inflammation/Immunology
Cancer
|
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ.
|
-
- HY-N7015
-
Zerumbone
|
HSV
|
Infection
|
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity.
|
-
- HY-N0004
-
Oridonin
NSC-250682; Isodonol
|
Akt
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
|
-
- HY-N2923
-
-
- HY-N2082
-
Isorhamnetin 3-O-galactoside
Cacticin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities.
|
-
- HY-121054
-
Chalcone
|
Bacterial
|
Cancer
Inflammation/Immunology
|
Chalcone is isolated from Glycyrrhizae inflata and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities.
|
-
- HY-101021
-
Ascochlorin
Ilicicolin D
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity.
|
-
- HY-N2005
-
-
- HY-N6894
-
Pseudocoptisine acetate
Isocoptisine acetate
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
|
-
- HY-N4288
-
-
- HY-N6894A
-
Pseudocoptisine chloride
Isocoptisine chloride
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
|
-
- HY-147179
-
-
- HY-N0625A
-
-
- HY-133588
-
-
- HY-116442
-
Azapropazone
|
Others
|
Inflammation/Immunology
|
Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions.
|
-
- HY-B1015
-
Etosalamide
Ethosalamide
|
Others
|
Inflammation/Immunology
|
Etosalamide (Ethosalamide) is an antipyretic and analgesic agent. Etosalamide has anti-inflammatory activity and can be used for allergic disease research.
|
-
- HY-N7036
-
-
- HY-108528
-
-
- HY-N2488
-
-
- HY-139578
-
-
- HY-B0493
-
-
- HY-N0891
-
Tubeimoside II
Tubeimoside-B
|
Others
|
Cancer
|
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
-
- HY-N0028
-
-
- HY-N7694
-
-
- HY-135658
-
-
- HY-N6904
-
-
- HY-B1153
-
Glafenine
Glafenin
|
Others
|
Inflammation/Immunology
|
Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
|
-
- HY-N7924
-
-
- HY-N1037
-
-
- HY-N0661
-
-
- HY-A0273
-
Propyphenazone
4-Isopropylantipyrine; Isopropylphenazone
|
COX
|
Inflammation/Immunology
|
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-W031757
-
-
- HY-N2597
-
-
- HY-N1408
-
-
- HY-78131B
-
-
- HY-N0720
-
Neobavaisoflavone
|
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation.
|
-
- HY-114335
-
Triphala
|
NF-κB
Fungal
|
Cancer
Infection
Inflammation/Immunology
|
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
|
-
- HY-N2127
-
Pinostrobin
|
Ser/Thr Protease
|
Inflammation/Immunology
|
Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management.
|
-
- HY-N1485
-
Cycloastragenol
Astramembrangenin; Cyclosieversigenin
|
Telomerase
|
Inflammation/Immunology
Neurological Disease
|
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties.
|
-
- HY-N0790
-
Lupeol
Clerodol; Monogynol B; Fagarasterol
|
Androgen Receptor
Apoptosis
|
Cancer
|
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC).
|
-
- HY-N0664
-
Aucubin
|
Bacterial
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.
|
-
- HY-12383
-
Pelubiprofen
|
COX
|
Inflammation/Immunology
Neurological Disease
|
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-107794
-
Clodronate disodium tetrahydrate
Disodium clodronate tetrahydrate
|
Others
|
Inflammation/Immunology
Neurological Disease
|
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl - competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
|
-
- HY-17492S2
-
-
- HY-100775
-
-
- HY-100775A
-
-
- HY-17492S1
-
-
- HY-A0203
-
Pentosan Polysulfate
|
HIV
|
Infection
Inflammation/Immunology
|
Pentosan Polysulfate is an orally bioavailable medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate also displays a potent and selective anti-HIV activity. Pentosan Polysulfatecan be used for the research of interstitial cystitis.
|
-
- HY-100382
-
FPTQ
|
mGluR
|
Others
|
FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.
|
-
- HY-108249
-
Tribenoside
|
Others
|
Inflammation/Immunology
|
Tribenoside is a vasoprotective agent, can be used for the research of hemorrhoids. Tribenoside has mild anti-inflammatory, analgesic, and wound healing properties.
|
-
- HY-N0015
-
Astragalin
Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds.
|
-
- HY-132405S
-
-
- HY-N0476
-
Wilforlide A
Regelide; Abruslactone A
|
Others
|
Inflammation/Immunology
|
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects.
|
-
- HY-113442
-
-
- HY-N0940
-
-
- HY-76251
-
-
- HY-121323
-
-
- HY-19217
-
-
- HY-N7697A
-
-
- HY-B0808S
-
Oxaprozin D4
Wy-21743 D4
|
COX
|
Others
|
Oxaprozin D4 (Wy-21743 D4) is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID).
|
-
- HY-N1433
-
-
- HY-B0580A
-
-
- HY-105014
-
-
- HY-13609
-
-
- HY-121076
-
-
- HY-N0828
-
Pterostilbene
|
Autophagy
|
Cancer
Inflammation/Immunology
|
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties. Pterostilbene blocks ROS production, also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide.
|
-
- HY-P0256
-
-
- HY-13696
-
-
- HY-N3005
-
Britannin
|
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities.
|
-
- HY-B0154
-
-
- HY-N2000
-
Bellidifolin
|
HIV
|
Cancer
Infection
Inflammation/Immunology
|
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.
|
-
- HY-N7906
-
-
- HY-N4187
-
-
- HY-N5077
-
-
- HY-N7030
-
5,7,3',4'-Tetramethoxyflavone
|
Fungal
Parasite
|
Infection
|
5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling.
|
-
- HY-N1677
-
2,6-Dimethoxy-1,4-benzoquinone
|
Bacterial
Parasite
|
Cancer
Infection
Metabolic Disease
Inflammation/Immunology
|
2,6-Dimethoxy-1,4-benzoquinone, a natural phytochemical, is a known haustorial inducing factor. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimalaria effects.
子
|
-
- HY-N7643
-
-
- HY-121481
-
Cucurbitadienol
10α-Cucurbitadienol
|
Others
|
Inflammation/Immunology
|
Cucurbitadienol (10α-Cucurbitadienol) is a natural product that can be found in the seeds of Trichosanthes kirilowii. Cucurbitadienol exhibits anti-inflammatory effect.
|
-
- HY-N2909
-
Aurantiamide
|
Others
|
Inflammation/Immunology
|
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities.
|
-
- HY-B1026
-
-
- HY-137454
-
-
- HY-147811
-
-
- HY-B2191
-
Sodium gualenate
Guaiazulenesulfonate sodium
|
Others
|
Inflammation/Immunology
|
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
|
-
- HY-144773
-
-
- HY-B0482S
-
Acemetacin-d4
|
COX
|
Inflammation/Immunology
|
Acemetacin-d4 is the deuterium labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-N2367
-
-
- HY-103325
-
-
- HY-17480
-
Bendazac
|
Others
|
Inflammation/Immunology
|
Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties. Bendazac acts by preventing protein denaturation and delays the cataractogenic process.
|
-
- HY-135301
-
-
- HY-N7993
-
-
- HY-N3509
-
Hyponine E
(-)-Hyponine E
|
Others
|
Inflammation/Immunology
|
Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects.
|
-
- HY-B1046
-
-
- HY-13219
-
-
- HY-N0708
-
-
- HY-N10423
-
Cubebin
(-)-Cubebin
|
Others
|
Inflammation/Immunology
|
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity.
|
-
- HY-N2601
-
-
- HY-N2276
-
Nodakenetin
|
Others
|
Inflammation/Immunology
|
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic.
|
-
- HY-N0263
-
Toosendanin
|
Others
|
Inflammation/Immunology
|
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.
|
-
- HY-N7931
-
-
- HY-N0180S
-
-
- HY-N0691
-
Schisandrin
Schizandrin; Schizandrol; Schizandrol-A
|
Autophagy
|
Inflammation/Immunology
Cancer
|
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats.
|
-
- HY-N7766
-
Rubropunctatin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.
|
-
- HY-A0203A
-
Pentosan Polysulfate Sodium (W/W 43%)
|
HIV
|
Infection
Inflammation/Immunology
|
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.
|
-
- HY-146053
-
-
- HY-N2080
-
Songorine
|
GABA Receptor
|
Cancer
|
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC).
|
-
- HY-13693S
-
-
- HY-N1353
-
-
- HY-N2010
-
-
- HY-N0439
-
-
- HY-N0295
-
Protocatechualdehyde
Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV
|
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
|
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.
|
-
- HY-N7765
-
-
- HY-12687
-
Tizoxanide
TIZ
|
Bacterial
HIV
Autophagy
Parasite
IKK
Influenza Virus
|
Cancer
Infection
|
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
|
-
- HY-N0120
-
(E/Z)-Polydatin
(E/Z)-Piceid
|
Others
|
Inflammation/Immunology
|
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions.
|
-
- HY-17492S
-
-
- HY-114454
-
INH14
|
IKK
|
Cancer
Inflammation/Immunology
|
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.
|
-
- HY-N0108
-
Physcion
Parietin; Rheochrysidin
|
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.
|
-
- HY-N5077B
-
-
- HY-N0450
-
Sinapine thiocyanate
|
P-glycoprotein
Cholinesterase (ChE)
|
Cancer
|
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
|
-
- HY-131502
-
Taspine
|
P2X Receptor
|
Inflammation/Immunology
|
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage.
|
-
- HY-13693
-
-
- HY-N4097
-
Incensole
|
Others
|
Neurological Disease
|
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression.
|
-
- HY-N0677
-
-
- HY-N0589
-
-
- HY-B0539
-
-
- HY-135408
-
-
- HY-N0188
-
Esculin
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway.
|
-
- HY-P0256A
-
-
- HY-108746
-
Defibrotide sodium
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research.
|
-
- HY-B0212
-
Sulfapyridine
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities.
|
-
- HY-B0559
-
Nabumetone
BRL14777
|
COX
|
Inflammation/Immunology
Cancer
|
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.
|
-
- HY-N0006
-
-
- HY-B1203S
-
-
- HY-30235A
-
-
- HY-N6864
-
Isovanillic acid
3-Hydroxy-4-methoxybenzoic acid
|
Others
|
Inflammation/Immunology
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from S. frutescens, with Anti-inflammatory activity.
|
-
- HY-N7640
-
Deoxylimonin
|
Others
|
Cancer
Inflammation/Immunology
|
Desoxylimonin is a triterpenoid compound isolated from grapefruit seed. Desoxylimonin derivatives has better anticancer, analgesic and anti-inflammatory activitythan the lead compound.
|
-
- HY-N3007
-
Naringenin chalcone
|
Others
|
Inflammation/Immunology
|
Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone has anti-inflammatory and antiallergic activities.
|
-
- HY-B1597
-
-
- HY-N5043
-
-
- HY-N7630
-
-
- HY-N2055
-
-
- HY-13236
-
-
- HY-N5042
-
-
- HY-111927
-
Pilloin
|
Others
|
Cancer
Inflammation/Immunology
|
Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.
|
-
- HY-N0105
-
-
- HY-N5007
-
Galgravin
|
Apoptosis
|
Cancer
|
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells.
|
-
- HY-107961
-
Diflorasone diacetate
|
Others
|
Inflammation/Immunology
|
Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses.
|
-
- HY-N7275
-
-
- HY-N1380
-
-
- HY-B1754
-
Rimexolone
Org 6216; Rimexel
|
Others
|
Inflammation/Immunology
|
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
|
-
- HY-N5015
-
Rosmanol
|
Others
|
Inflammation/Immunology
Cancer
|
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
|
-
- HY-N0021
-
-
- HY-W012634
-
-
- HY-117586
-
-
- HY-N0346A
-
-
- HY-N0232
-
Psoralidin
|
COX
Lipoxygenase
Notch
Reactive Oxygen Species
Bacterial
|
Cancer
|
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.
|
-
- HY-W015007
-
Metyrosine
|
COX
|
Cardiovascular Disease
|
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
|
-
- HY-N8593
-
Undecane
|
TNF Receptor
|
Infection
|
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[
|
-
- HY-N8471
-
Niazinin
|
Parasite
SARS-CoV
|
Infection
Inflammation/Immunology
|
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity.
|
-
- HY-N0677B
-
-
- HY-N1535
-
Ponicidin
Rubescensine B
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.
|
-
- HY-N4150
-
Quercetagitrin
Quercetagetin-7-O-glucoside
|
Others
|
Inflammation/Immunology
|
Quercetagitrin (Quercetagetin-7-O-glucoside), isolated from the flowers of the African Marigold (Tagetes erecta), has anti-inflammatory activity.
|
-
- HY-121851
-
Revaprazan
SB 641257
|
Proton Pump
|
Inflammation/Immunology
|
Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research.
|
-
- HY-N9438
-
-
- HY-112675
-
-
- HY-132196
-
-
- HY-138558
-
-
- HY-13570A
-
-
- HY-107617
-
PTIQ
|
MMP
|
Neurological Disease
|
PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells.
|
-
- HY-N0153
-
-
- HY-N0037
-
-
- HY-N6020A
-
(+)-Butin
|
Others
|
Others
|
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-125711
-
-
- HY-17509S
-
Deracoxib-d3
SC 046-d3; SC 46-d3; SC 59046-d3
|
COX
Apoptosis
|
Inflammation/Immunology
|
Deracoxib-d3 is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
|
-
- HY-N3500
-
-
- HY-126941
-
Hecogenin acetate
|
Opioid Receptor
|
Neurological Disease
|
Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors.
|
-
- HY-30152
-
-
- HY-N2074
-
Picrinine
|
Lipoxygenase
|
Inflammation/Immunology
|
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
|
-
- HY-13570
-
-
- HY-103662
-
-
- HY-B1355A
-
-
- HY-13751
-
-
- HY-N0436
-
Engeletin
|
NF-κB
|
Infection
Inflammation/Immunology
|
Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
|
-
- HY-N0697
-
-
- HY-128934
-
-
- HY-104026B
-
-
- HY-N7697C
-
-
- HY-N8174
-
-
- HY-18978
-
GR79236
|
Adenosine Receptor
|
Inflammation/Immunology
|
GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a Kis of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions.
|
-
- HY-108966
-
Kushenol C
|
Beta-secretase
|
Inflammation/Immunology
|
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM.
|
-
- HY-N2521
-
Tetramethylcurcumin
FLLL31
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects.
|
-
- HY-W018800
-
-
- HY-N4233
-
Bisabolangelone
|
p38 MAPK
|
Inflammation/Immunology
|
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities.
|
-
- HY-N1934
-
-
- HY-N0526
-
2"-O-Galloylhyperin
|
Others
|
Inflammation/Immunology
|
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage.
|
-
- HY-N0327
-
Lobetyolin
|
Apoptosis
Xanthine Oxidase
|
Metabolic Disease
|
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.
|
-
- HY-N0829
-
Shionone
|
Others
|
Inflammation/Immunology
|
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities. Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure.
|
-
- HY-129611
-
Bromelain
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
|
-
- HY-105028S
-
Tenidap-d3
CP-66248-d3
|
COX
|
Inflammation/Immunology
|
Tenidap-d3 (CP-66248-d3) is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-145307
-
DATPT
|
Bacterial
|
Infection
Inflammation/Immunology
|
DATPT is a 12WLVSKF17 peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis.
|
-
- HY-N0192
-
Arbutin
β-Arbutin
|
Tyrosinase
|
Cancer
|
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Ki app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.
|
-
- HY-B0289S
-
-
- HY-13516
-
Aloperine
|
Apoptosis
Autophagy
Filovirus
HIV
|
Cancer
Infection
Inflammation/Immunology
|
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties.
Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
|
-
- HY-B0715
-
Pentoxifylline
BL-191; PTX; Oxpentifylline
|
Phosphodiesterase (PDE)
Autophagy
HIV
|
Cardiovascular Disease
Cancer
|
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
|
-
- HY-N4042
-
Hirsutenone
|
PI3K
ERK
|
Cancer
Inflammation/Immunology
|
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity.
|
-
- HY-145532
-
S-Allylmercaptocysteine
|
Apoptosis
NF-κB
Keap1-Nrf2
|
Cancer
Inflammation/Immunology
|
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation.
|
-
- HY-N0068
-
-
- HY-N2406
-
-
- HY-B1453
-
-
- HY-121046S
-
Flunixin-d3
|
COX
|
Inflammation/Immunology
|
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
|
-
- HY-N6020
-
(-)-Butin
|
Others
|
Inflammation/Immunology
|
(-)-Butin is the S enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-U00157
-
Meseclazone
W2395; NSC297623
|
Others
|
Inflammation/Immunology
|
Meseclazone (W2395;NSC297623) exhibits inhibitory potency of secondary phase ADP aggregation. Meseclazone possesses anti-inflammatory, analgesic and antipyretic activity.
|
-
- HY-W019940
-
-
- HY-N9315
-
-
- HY-N0023
-
Cistanoside A
|
NO Synthase
|
Inflammation/Immunology
|
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect.
|
-
- HY-N1981S1
-
Triolein-d5
|
MMP
Endogenous Metabolite
|
|
Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties.
|
-
- HY-Z0548
-
-
- HY-137992
-
Aucuparin
|
Others
|
Inflammation/Immunology
|
Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. Anti-inflammatory activity.
|
-
- HY-N7067
-
Revaprazan hydrochloride
|
Bacterial
COX
|
Infection
|
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection.
|
-
- HY-N0493
-
-
- HY-126296
-
-
- HY-B0625S
-
-
- HY-N7190
-
Yadanzioside F
|
Others
|
Cancer
|
Yadanzioside F is one of the toxic components found in Brucea javanica. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties.
|
-
- HY-N2149A
-
-
- HY-N2149
-
-
- HY-N10454
-
-
- HY-N0812
-
-
- HY-N0826
-
-
- HY-N10453
-
-
- HY-147963
-
COX-2-IN-24
|
COX
|
Infection
|
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
|
-
- HY-139199
-
4-Hydroxyphenylbutazone
|
Drug Metabolite
|
Others
|
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
|
-
- HY-N7697D
-
-
- HY-N6641
-
Monascin
|
Others
|
Cancer
Inflammation/Immunology
|
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor).
|
-
- HY-N5091
-
-
- HY-126390
-
(E/Z)-BCI
NSC 150117
|
Phosphatase
Apoptosis
|
Cancer
Inflammation/Immunology
|
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
|
-
- HY-147527
-
CDK8-IN-5
|
CDK
|
Inflammation/Immunology
|
CDK8-IN-5 is a potent CDK8 inhibitor with an IC50 of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease.
|
-
- HY-N0677A
-
Kalii Dehydrographolidi Succinas
Potassium dehydroandrographolide succinate
|
Others
|
Infection
Inflammation/Immunology
Cancer
|
Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
|
-
- HY-N8213
-
-
- HY-14289A
-
Cimetidine hydrochloride
SKF-92334 hydrochloride
|
Histamine Receptor
|
Cancer
Endocrinology
|
Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.
|
-
- HY-N6624
-
Skullcapflavone II
|
Bacterial
|
Inflammation/Immunology
|
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.
|
-
- HY-14289
-
Cimetidine
SKF-92334
|
Histamine Receptor
|
Cancer
Endocrinology
|
Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity.
|
-
- HY-N0496
-
Ruscogenin
|
NOD-like Receptor (NLR)
|
Cardiovascular Disease
|
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities.
|
-
- HY-N3078
-
-
- HY-12412
-
ML132
NCGC-00183434
|
Caspase
|
Cancer
Inflammation/Immunology
|
ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of caspase 1. ML132 can be used for research in the field of anti-cancer and anti-inflammatory.
|
-
- HY-107577
-
Gedunin
|
HSP
|
Cancer
Infection
Inflammation/Immunology
|
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research.
|
-
- HY-N3187
-
-
- HY-10582
-
Flurbiprofen
dl-Flurbiprofen
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
|
-
- HY-N0314
-
-
- HY-N6878
-
Cauloside D
|
Others
|
Inflammation/Immunology
|
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-N1429
-
-
- HY-N0795
-
-
- HY-W004294
-
-
- HY-N2518
-
-
- HY-B0972
-
Cinchophen
|
Bacterial
|
Inflammation/Immunology
|
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
|
-
- HY-N6829
-
Retusin
Quercetin-3,3',4',7-tetramethylether
|
Others
|
Infection
Inflammation/Immunology
|
Retusin (Quercetin-3,3',4',7-tetramethylether), a natural compound isolated from the leaves of Talinum triangulare, possesses antiviral and anti-inflammatory activities.
|
-
- HY-N0564
-
-
- HY-N4111
-
-
- HY-N2189
-
-
- HY-N2027
-
-
- HY-N6919
-
Cauloside C
|
Others
|
Inflammation/Immunology
|
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-107632
-
-
- HY-13751A
-
-
- HY-B1616
-
-
- HY-N0297S
-
Sinensetin-d3
|
PGE synthase
TNF Receptor
|
Others
|
Sinensetin-d3 is the deuterium labeled Sinensetin. Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
|
-
- HY-Y0148
-
-
- HY-N0399
-
-
- HY-128346
-
PQM130
|
Amyloid-β
|
Neurological Disease
|
PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development.
|
-
- HY-N0579
-
Fraxin
Fraxoside
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.
|
-
- HY-10448S1
-
Capsaicin-d3
(E)-Capsaicin-d3
|
TRP Channel
Autophagy
Apoptosis
Endogenous Metabolite
|
Cancer
|
Capsaicin-d3 ((E)-Capsaicin-d3) is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.
|
-
- HY-N0328
-
-
- HY-N6642
-
Ankaflavin
|
PPAR
Apoptosis
|
Cancer
Inflammation/Immunology
|
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
|
-
- HY-N0448
-
10-Gingerol
|
Others
|
Cancer
Inflammation/Immunology
|
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM.
|
-
- HY-N2920
-
β-Amyrenonol
11-Oxo-β-amyrin
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.
|
-
- HY-N1231
-
Sophoraflavanone G
Kushenol F
|
Apoptosis
|
Cancer
|
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
|
-
- HY-N7072
-
-
- HY-B0808A
-
Oxaprozin potassium
Oxaprozinum potassium; Wy21743 potassium
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Cancer
Inflammation/Immunology
|
Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-12383S
-
Pelubiprofen-13C,d3
|
COX
|
Inflammation/Immunology
Neurological Disease
|
Pelubiprofen-13C,d3 is the 13C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-B0808
-
Oxaprozin
Oxaprozinum; Wy21743
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Inflammation/Immunology
Cancer
|
Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-B1121
-
-
- HY-B1042
-
Oxolamine citrate
SKF-9976 citrate; AF-438 citrate
|
Others
|
Inflammation/Immunology
|
Oxolamine citrate (SKF-9976 citrate) is a cough suppressant that can be used for the research of respiratory tract diseases. Oxolamine citrate also exhibits anti-inflammatory effect.
|
-
- HY-32291
-
Methyl L-pyroglutamate
(S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
|
Others
|
Others
|
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
|
-
- HY-17490
-
Oxaceprol
N-Acetyl-L-hydroxyproline
|
Others
|
Inflammation/Immunology
|
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
|
-
- HY-113556
-
-
- HY-N1981S
-
-
- HY-N0114A
-
-
- HY-N10297
-
-
- HY-121362
-
-
- HY-N7036S
-
Rhamnetin-d3
|
Phospholipase
|
Inflammation/Immunology
|
Rhamnetin-d3 is the deuterium labeled Rhamnetin. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2, with antioxidant and anti-inflammatory activity.
|
-
- HY-103386
-
FR122047
|
COX
|
Inflammation/Immunology
|
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo.
|
-
- HY-N8096
-
Raddeanoside R17
Pulchinenoside E3
|
Others
|
Inflammation/Immunology
|
Raddeanoside R17 (Pulchinenoside E3) is a saponin compound that can be isolated from the root of Pulsatilla koreana. Raddeanoside R17 shows anti-inflammatory effects.
|
-
- HY-N1109
-
Uvaol
|
Others
Endogenous Metabolite
|
Inflammation/Immunology
|
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.
|
-
- HY-122402
-
Umirolimus
|
Others
|
Inflammation/Immunology
|
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications.
|
-
- HY-N2543
-
-
- HY-N0635
-
-
- HY-18342
-
Diflunisal
MK-647
|
COX
|
Inflammation/Immunology
Cancer
|
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-B1130
-
Isoxicam
|
COX
|
Inflammation/Immunology
|
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam is a nonselective inhibitor of COX-1 and COX-2.
|
-
- HY-B0260
-
-
- HY-N2270
-
-
- HY-107591
-
PF-184
|
IKK
|
Inflammation/Immunology
|
PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. PF-184 has anti-inflammatory effects.
|
-
- HY-N0115
-
-
- HY-N2473
-
-
- HY-A0273S
-
Propyphenazone-d3
|
COX
|
Inflammation/Immunology
|
Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-N8253
-
Spiraeoside
Quercetin 4′-O-glucoside
|
Reactive Oxygen Species
|
Cancer
Inflammation/Immunology
|
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.
|
-
- HY-B1121A
-
-
- HY-113334
-
-
- HY-N1382
-
Asperuloside
|
NO Synthase
|
Inflammation/Immunology
|
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.
|
-
- HY-14621
-
Zingerone
Vanillylacetone; Gingerone
|
NF-κB
|
Cancer
Metabolic Disease
Inflammation/Immunology
|
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.
|
-
- HY-137941
-
Roxatidine
|
Histamine Receptor
|
Inflammation/Immunology
|
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect.
|
-
- HY-N1390
-
Syringaldehyde
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
|
-
- HY-N6025
-
Clemastanin B
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
|
-
- HY-109567
-
Gemcabene
PD-72953
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.
|
-
- HY-N7012
-
7,3',4'-Tri-O-methylluteolin
5-Hydroxy-3',4',7-trimethoxyflavone
|
TNF Receptor
Interleukin Related
COX
|
Inflammation/Immunology
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2.
|
-
- HY-B0154S1
-
-
- HY-B0335
-
Tolfenamic Acid
GEA 6414
|
COX
|
Inflammation/Immunology
Cancer
|
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-B0539S3
-
-
- HY-N0201
-
Atractylenolide I
|
Toll-like Receptor (TLR)
JAK
STAT
|
Cancer
|
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
|
-
- HY-N0389
-
Columbin
|
COX
Parasite
|
Inflammation/Immunology
|
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM).
|
-
- HY-N1181S
-
Tamarixetin-d3
4'-O-Methyl Quercetin-d3
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Tamarixetin-d3 (4'-O-Methyl Quercetin-d3) is the deuterium labeled Tamarixetin. Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy.
|
-
- HY-B0154S
-
-
- HY-117726
-
-
- HY-N2266
-
-
- HY-13609S1
-
-
- HY-100599
-
-
- HY-N6065
-
Praeruptorin A
|
NF-κB
|
Inflammation/Immunology
|
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation.
|
-
- HY-B0138
-
Ketorolac tromethamine salt
Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt
|
COX
|
Inflammation/Immunology
|
Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-107203
-
-
- HY-13324
-
Bardoxolone methyl
RTA 402; NSC 713200; CDDO Methyl ester
|
Keap1-Nrf2
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
|
-
- HY-130494
-
-
- HY-135654
-
-
- HY-N2081
-
Skimmianine
|
Others
|
Cancer
Inflammation/Immunology
|
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity.
|
-
- HY-N7688
-
-
- HY-107795
-
-
- HY-B0712
-
Ceftriaxone
|
Bacterial
Antibiotic
|
Infection
|
Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-N0133
-
Tangeretin
Tangeritin; NSC53909; NSC618905
|
Notch
Apoptosis
|
Inflammation/Immunology
Cancer
|
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
|
-
- HY-N2162
-
12-Epinapelline
|
Others
|
Inflammation/Immunology
|
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors.
|
-
- HY-N3006
-
Sakuranetin
|
Fungal
|
Infection
Inflammation/Immunology
|
Sakuranetin is a rice flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
|
-
- HY-N2989
-
-
- HY-N1200
-
-
- HY-N6038
-
Gartanin
|
Fungal
Autophagy
|
Cancer
|
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.
|
-
- HY-B2175
-
Aspirin Aluminum
Aluminum diacetylsalicylate
|
Others
|
Inflammation/Immunology
|
Aspirin Aluminum is a novel intermolecular compound which can inhibit gastrointestinal mucosal disorders induced by NSAIDs (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.
|
-
- HY-N2258
-
Poncirin
|
Apoptosis
|
Inflammation/Immunology
|
Poncirin is isolated from Poncirus trifoliata with anti-inflammory activites. Poncirin significantly reduces mechanical hyperalgesia and allodynia in Complete Freund’s Adjuvant (CFA)-induced inflammatory pain models.
|
-
- HY-126121
-
-
- HY-115931
-
-
- HY-122951
-
Eburicoic acid
|
Others
|
Cardiovascular Disease
|
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. And Eburicoic acid has antidiabetic and antihyperlipidemic effects.
|
-
- HY-N0584A
-
Anisodamine hydrobromide
6-Hydroxyhyoscyamine hydrobromide
|
mAChR
|
Inflammation/Immunology
|
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties.
|
-
- HY-N0627
-
-
- HY-N10448
-
-
- HY-139607
-
-
- HY-N0737
-
-
- HY-N1482
-
Methyl palmitate
|
Others
|
Inflammation/Immunology
|
Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.
|
-
- HY-13609S
-
-
- HY-N7255
-
Cycloartenol
|
p38 MAPK
Apoptosis
|
Cancer
|
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development.
|
-
- HY-N0615
-
Notoginsenoside R1
Sanchinoside R1; Sanqi glucoside R1
|
Amyloid-β
Apoptosis
|
Others
|
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.
|
-
- HY-N0692
-
Schisandrol B
Gomisin-A; TJN-101; Wuweizi alcohol-B
|
Reactive Oxygen Species
Cytochrome P450
Autophagy
|
Cancer
|
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.
|
-
- HY-B0578S
-
Loxoprofen-d4
|
COX
|
Inflammation/Immunology
|
Loxoprofen-d4 is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively.
|
-
- HY-N0162
-
Luteolin
Luteoline; Luteolol; Digitoflavone
|
Keap1-Nrf2
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
Inflammation/Immunology
|
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.
|
-
- HY-N7437
-
-
- HY-17474A
-
Parecoxib Sodium
SC 69124A
|
COX
|
Inflammation/Immunology
Cancer
|
Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-147748
-
COX-2-IN-17
|
COX
|
Inflammation/Immunology
|
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase.
|
-
- HY-17474
-
Parecoxib
SC 69124
|
COX
|
Cancer
Inflammation/Immunology
|
Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-109567A
-
Gemcabene calcium
PD-72953 calcium
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.
|
-
- HY-131259
-
-
- HY-N2381
-
Menthone
|
Parasite
|
Infection
Inflammation/Immunology
|
Menthone, a monoterpene extracted from plants and Mentha oil with strong antioxidant properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni Infection.
|
-
- HY-B1121S
-
-
- HY-N7560
-
Safranal
|
Others
|
Inflammation/Immunology
Neurological Disease
|
Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.
|
-
- HY-N3925
-
-
- HY-B1046S
-
Clofazimine-d7
|
Bacterial
Antibiotic
|
Inflammation/Immunology
|
Clofazimine-d7 is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
|
-
- HY-76251S
-
-
- HY-N2195
-
Nootkatone
(+)-Nootkatone
|
Others
|
Neurological Disease
|
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease.
|
-
- HY-B0367S
-
-
- HY-N6644
-
Crocin III
|
Others
|
Cancer
Inflammation/Immunology
|
Crocin III is a crocetin from saffron (Crocus sutivus L.). Crocetins inhibit cell growth of tumor cells and has anti-inflammatory activity. Crocins serve as spices and coloring agents.
|
-
- HY-32735
-
Triptolide
PG490
|
NF-κB
Apoptosis
|
Cancer
|
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor.
|
-
- HY-N0194
-
-
- HY-N1205
-
Spathulenol
|
Others
|
Cancer
|
Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].
|
-
- HY-131258
-
-
- HY-137394
-
Nicotredole
Tryptamide
|
Others
|
Inflammation/Immunology
|
Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.
|
-
- HY-131260
-
-
- HY-13609S2
-
-
- HY-N2410
-
N-trans-Feruloyltyramine
N-feruloyltyramine; Moupinamide
|
COX
|
Inflammation/Immunology
|
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity.
|
-
- HY-N2495
-
Isomucronulatol
|
Others
|
Inflammation/Immunology
|
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect.
|
-
- HY-101784
-
-
- HY-N10450
-
-
- HY-N10225
-
Thielavin A
|
Prostaglandin Receptor
|
Endocrinology
Cardiovascular Disease
|
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration.
|
-
- HY-32345
-
Elocalcitol
BXL-628; Ro-26-9228
|
VD/VDR
|
Cancer
Inflammation/Immunology
|
Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells.
|
-
- HY-N3115
-
Palbinone
|
Others
|
Inflammation/Immunology
|
Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits 3α-hydroxysteroid dehydrogenase (3α-HSD), with an IC50 of 46 nM. Anti-inflammatory activity.
|
-
- HY-N9488
-
-
- HY-N2593
-
Isorhapontigenin
|
Autophagy
|
Cancer
Inflammation/Immunology
|
Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation.
|
-
- HY-N1422
-
Hecogenin
|
Fungal
|
Infection
Inflammation/Immunology
|
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.
|
-
- HY-122381
-
Kyotorphin
|
Bacterial
Endogenous Metabolite
|
Neurological Disease
|
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients.
|
-
- HY-12403
-
Angiotensin (1-7)
Ang-(1-7)
|
Angiotensin Receptor
Angiotensin-converting Enzyme (ACE)
Endogenous Metabolite
|
Inflammation/Immunology
Cardiovascular Disease
Endocrinology
|
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
|
-
- HY-126397
-
MnTBAP chloride
|
NF-κB
|
Inflammation/Immunology
|
MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.
|
-
- HY-107046
-
UK-432097
|
Adenosine Receptor
|
Inflammation/Immunology
|
UK-432097 is a highly potent and selective A2AAR agonist with a pKi of 8.4 for human A2AAR. UK-432097 has anti-inflammatory and anti-aggregatory properties. UK-432097 has the potential for COPD (Chronic Obstructive Pulmonary Disease) research.
|
-
- HY-N5011
-
5,7-Dimethoxyflavone
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor.
|
-
- HY-19149
-
-
- HY-B0195
-
-
- HY-N0794
-
Proanthocyanidins
|
Bacterial
Fungal
|
Cancer
Infection
Inflammation/Immunology
Cardiovascular Disease
|
Proanthocyanidins are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidins can be used as antioxidant and anti-cancers agent. Proanthocyanidins also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy..
|
-
- HY-A0143
-
-
- HY-B0195A
-
-
- HY-16125
-
Carboxyamidotriazole Orotate
L-651582 Orotate; CAI Orotate
|
Calcium Channel
|
Cancer
Inflammation/Immunology
|
Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
|
-
- HY-N0293
-
Paeoniflorin
Peoniflorin
|
HSP
|
Cancer
Infection
Neurological Disease
|
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
|
-
- HY-128463
-
-
- HY-19827
-
Aeroplysinin 1
(+)-Aeroplysinin-1
|
Bacterial
HIV
Apoptosis
|
Cancer
Infection
|
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.
|
-
- HY-N0192S
-
Arbutin-d4
β-Arbutin-d4
|
Tyrosinase
Endogenous Metabolite
|
Cancer
|
Arbutin-d4 is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties.
|
-
- HY-N7652
-
Terminolic acid
|
Bacterial
|
Infection
Inflammation/Immunology
|
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity.
|
-
- HY-147697
-
-
- HY-14645
-
(-)-DHMEQ
Dehydroxymethylepoxyquinomicin
|
NF-κB
|
Cancer
Inflammation/Immunology
|
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity.
|
-
- HY-106907
-
-
- HY-17358
-
-
- HY-150608
-
-
- HY-B0890
-
Zomepirac sodium salt
McN-2783-21-98
|
PGE synthase
|
Inflammation/Immunology
|
Zomepirac sodium salt (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac sodium salt is a non-steroidal anti-inflammatory drug (NSAID). Zomepirac sodium salt can cause immune-mediated liver injury.
|
-
- HY-N0708S
-
-
- HY-N2050
-
-
- HY-B0270S
-
-
- HY-B0758
-
Troxipide
|
Others
|
Inflammation/Immunology
|
Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties.
|
-
- HY-B0261A
-
-
- HY-108617
-
YM976
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses.
|
-
- HY-N6261
-
Epimagnolin B
|
Others
|
Inflammation/Immunology
|
Epimagnolin B is a bisepoxylignan isolated from Magnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic effects.
|
-
- HY-N2217
-
-
- HY-N2460
-
Aloesin
Aloeresin
|
Others
|
Cancer
Inflammation/Immunology
|
Aloesin (Aloeresin) is an active constituent of the herb aloe vera and displays anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin exerts its anticancer effect through the MAPK signaling pathway.
|
-
- HY-108570
-
AUDA
|
Epoxide Hydrolase
|
Inflammation/Immunology
|
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.
|
-
- HY-B0493S
-
-
- HY-B0253
-
Piroxicam
CP-16171
|
COX
|
Inflammation/Immunology
Cancer
|
Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.
|
-
- HY-B0712B
-
Ceftriaxone sodium salt
Disodium ceftriaxone
|
Bacterial
Antibiotic
|
Infection
|
Ceftriaxone sodium salt (Disodium ceftriaxone) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-W067056
-
Methyl (E)-cinnamate
Methyl (E)-3-phenylpropenoate
|
Others
|
Inflammation/Immunology
|
Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry.
|
-
- HY-N2094
-
Genipin 1-β-D-gentiobioside
Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside
|
Others
|
Inflammation/Immunology
|
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
|
-
- HY-N5083
-
Saponarin
|
Others
|
Inflammation/Immunology
|
Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.
|
-
- HY-N6612
-
-
- HY-N6826
-
Asatone
|
NF-κB
|
Inflammation/Immunology
|
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.
|
-
- HY-N0268
-
Irisflorentin
|
NO Synthase
|
Inflammation/Immunology
|
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity.
|
-
- HY-107574
-
-
- HY-B1078
-
-
- HY-N0637
-
-
- HY-B1892
-
-
- HY-N0755
-
Rhoifolin
|
Insulin Receptor
GLUT
NF-κB
p38 MAPK
Autophagy
|
Metabolic Disease
Endocrinology
Cancer
|
Rhoifolin is a flavone glycoside can be isolated from Citrus grandis (L.) Osbeck leaves. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.
|
-
- HY-19995
-
GSK137647A
GSK 137647
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response.
|
-
- HY-N1445
-
Isoquercetin
Quercetin 3-glucoside
|
NF-κB
NO Synthase
|
Inflammation/Immunology
Cancer
|
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.
|
-
- HY-W012126
-
2,6-Dichlorodiphenylamine
2,6-Dichloro-N-phenylaniline
|
Bacterial
|
Cancer
Infection
|
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
- HY-14658S
-
-
- HY-130208
-
Thiodigalactoside
TDG
|
Galectin
|
Cancer
Metabolic Disease
Inflammation/Immunology
|
Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
|
-
- HY-121636
-
Resolvin D2
RvD2
|
TRP Channel
|
Infection
Inflammation/Immunology
Neurological Disease
|
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.
|
-
- HY-14289S
-
Cimetidine-d3
SKF-92334-d3
|
Histamine Receptor
|
Cancer
Endocrinology
|
Cimetidine-d3 (SKF-92334-d3) is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity.
|
-
- HY-B0578
-
Loxoprofen
|
COX
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity.
|
-
- HY-100950
-
ABC1183
|
GSK-3
CDK
|
Cancer
Inflammation/Immunology
|
ABC1183 is a selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory effects and anti-tumor activity.
|
-
- HY-B0578A
-
Loxoprofen sodium
|
COX
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium can reduce atherosclerosis and shows antitumor activity.
|
-
- HY-N8211
-
Gypenoside L
|
p38 MAPK
ERK
NF-κB
|
Cancer
Inflammation/Immunology
|
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.
|
-
- HY-122267
-
-
- HY-19893
-
Antroquinonol
(+)-Antroquinonol
|
Keap1-Nrf2
|
Cancer
Inflammation/Immunology
|
Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects. Antroquinonol can be used for the research of colon cancer. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.
|
-
- HY-17461A
-
-
- HY-B0712A
-
Ceftriaxone sodium hydrate
Ceftriaxone disodium hemiheptahydrate
|
Bacterial
Antibiotic
|
Infection
|
Ceftriaxone sodium hydrate (Ceftriaxone disodium hemiheptahydrate) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-N4149
-
Quercetagetin
6-Hydroxyquercetin
|
Pim
|
Cancer
Inflammation/Immunology
|
Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
|
-
- HY-N0929
-
Hexahydrocurcumin
|
COX
Reactive Oxygen Species
|
Cancer
|
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities.
|
-
- HY-B0580S
-
Ketorolac-d5
|
COX
|
Inflammation/Immunology
|
Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-B1355AS
-
Oxyphenbutazone-d9
|
COX
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
Oxyphenbutazone-d9 is the deuterium labeled Oxyphenbutazone. Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
|
-
- HY-B0574
-
Mefenamic acid
|
COX
|
Inflammation/Immunology
|
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-126294
-
AZD4604
JAK1-IN-7
|
JAK
|
Inflammation/Immunology
|
AZD4604 (JAK1-IN-7) is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect.
|
-
- HY-14882A
-
-
- HY-N2169
-
Polygalasaponin V
|
Others
|
Inflammation/Immunology
|
Polygalasaponin V is a triterpenoid saponin isolated from the aerial parts of Polygala japonica. Polygala japonica has been a folk medicine herb used as expectorant, anti-inflammatory, antibacterial and antidepressant agents in the south of China.
|
-
- HY-W002484
-
3-Hydroxy-4-methoxyacetophenone
Acetoisovanillone; Isoacetovanillone
|
Others
|
Inflammation/Immunology
|
3-Hydroxy-4-methoxyacetophenone(Acetoisovanillone; Isoacetovanillone) is an active compound isolated from P. spinosa. Isoacetovanillone possesses anti-inflammatory activity and prevented injuries due to administration of acetic acid in the colon.
|
-
- HY-N0616
-
Trifolirhizin
|
Tyrosinase
|
Cancer
Inflammation/Immunology
|
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.
|
-
- HY-100009
-
Ufenamate
Flufenamic acid butyl ester; Butyl flufenamate
|
Others
|
Inflammation/Immunology
|
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory agent. Ufenamate can be used for the research of skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis.
|
-
- HY-147693
-
-
- HY-N9359
-
Toddaculin
|
Apoptosis
|
|
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity.
|
-
- HY-116429
-
-
- HY-133588S
-
-
- HY-146198
-
-
- HY-B1276A
-
-
- HY-N2569
-
-
- HY-N4147
-
-
- HY-N7541
-
Antrodin A
|
Others
|
Inflammation/Immunology
|
Antrodin A is one of the main active ingredients in the solid-state fermented A. camphorate mycelium. Antrodin A protects the liver from alcohol damage by improving the antioxidant and anti-inflammatory capacity of the liver and maintaining the stability of the intestinal flora.
|
-
- HY-125445
-
PCTR1
|
Others
|
Inflammation/Immunology
|
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
|
-
- HY-147119
-
-
- HY-N0141
-
Parthenolide
(-)-Parthenolide
|
NF-κB
Autophagy
Mitophagy
Apoptosis
|
Cancer
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
|
-
- HY-U00046
-
Apyramide
|
COX
|
Inflammation/Immunology
|
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.
|
-
- HY-N7335
-
-
- HY-13570S
-
-
- HY-17571A
-
Oxytocin acetate
α-Hypophamine acetate; Oxytocic hormone acetate
|
Oxytocin Receptor
Endogenous Metabolite
|
Endocrinology
|
Oxytocin acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
|
-
- HY-106093
-
Eltenac
|
COX
|
Inflammation/Immunology
|
Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood.
|
-
- HY-13633
-
Exisulind
|
Aldose Reductase
|
Metabolic Disease
|
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.
|
-
- HY-17474S
-
Parecoxib-d3
SC 69124-d3
|
COX
|
Cancer
Inflammation/Immunology
|
Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-10656
-
SB-657510
|
Urotensin Receptor
|
Inflammation/Immunology
|
SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
|
-
- HY-146483
-
Anti-Aβ agent 1A
|
Amyloid-β
|
Inflammation/Immunology
Neurological Disease
|
Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD).
|
-
- HY-N2556
-
Tirucallol
|
Others
|
Inflammation/Immunology
|
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages.
|
-
- HY-15556A
-
-
- HY-13571S
-
-
- HY-15556
-
-
- HY-128922
-
-
- HY-12136
-
-
- HY-145310
-
-
- HY-N2478
-
Taraxasteryl acetate
|
Others
|
Inflammation/Immunology
|
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment[1] .
|
-
- HY-N1508
-
Ecliptasaponin A
|
Others
|
Inflammation/Immunology
|
Ecliptasaponin A , a pentacyclic triterpenoid saponin, is one of major compounds separated from Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory.
|
-
- HY-15028
-
Otenaproxesul
ATB-346
|
COX
Apoptosis
|
Inflammation/Immunology
|
Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities.
|
-
- HY-118139
-
Desmethyl Celecoxib
|
COX
|
Inflammation/Immunology
|
Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.
|
-
- HY-111149A
-
PS372424 hydrochloride
|
CXCR
|
Inflammation/Immunology
|
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.
|
-
- HY-N0802
-
Tenuigenin
Senegenin
|
NF-κB
Bacterial
|
Infection
Inflammation/Immunology
|
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.
|
-
- HY-B1832S
-
-
- HY-18234A
-
Leupeptin hemisulfate
|
Cathepsin
|
Inflammation/Immunology
|
Leupeptin hemisulfate is a membrane-permeable thiol protease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion. Leupeptin hemisulfate also exhibits anti-inflammatory effect.
|
-
- HY-W062696
-
-
- HY-N0608
-
Myrislignan
|
NF-κB
|
Inflammation/Immunology
|
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.
|
-
- HY-N5113
-
6α-Chloro-5β-hydroxywithaferin A
|
Others
|
Others
|
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties.
|
-
- HY-N4108
-
Hypophyllanthin
|
P-glycoprotein
|
Cancer
Inflammation/Immunology
|
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity.
|
-
- HY-N0220
-
Dauricine
|
NF-κB
Apoptosis
|
Cancer
Inflammation/Immunology
|
Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.
|
-
- HY-146046
-
Antitumor agent-56
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active.
|
-
- HY-111149
-
PS372424
|
CXCR
|
Inflammation/Immunology
|
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.
|
-
- HY-147809
-
COX-2-IN-20
|
COX
|
Inflammation/Immunology
|
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity.
|
-
- HY-13570S1
-
-
- HY-N0269
-
Echinatin
|
Others
|
Inflammation/Immunology
|
Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat.
|
-
- HY-N1404
-
Sodium aescinate
|
NF-κB
|
Cancer
Inflammation/Immunology
|
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
|
-
- HY-133916
-
-
- HY-14658A
-
-
- HY-13723A
-
Pimecrolimus hydrate
SDZ-ASM 981 hydrate
|
Phosphatase
|
Inflammation/Immunology
|
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus.
|
-
- HY-B0756
-
-
- HY-129098
-
DMHCA
|
LXR
|
Metabolic Disease
|
DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes.
|
-
- HY-147830
-
-
- HY-13755
-
Sulforaphane
|
HDAC
Keap1-Nrf2
Apoptosis
|
Cancer
Inflammation/Immunology
|
Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables. Sulforaphane increases tumor suppressor protein transcription and inhibits histone deacetylase activity. Sulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities.
|
-
- HY-B1452
-
Licofelone
ML-3000
|
COX
Lipoxygenase
Apoptosis
|
Cancer
Inflammation/Immunology
|
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.
|
-
- HY-B0539S
-
-
- HY-B0539S2
-
-
- HY-B0539S1
-
-
- HY-P1306
-
Obestatin(rat)
|
GHSR
|
Inflammation/Immunology
Cardiovascular Disease
|
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
|
-
- HY-P2268
-
RAGE antagonist peptide
|
Amyloid-β
|
Cancer
Inflammation/Immunology
|
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities.
|
-
- HY-14374
-
GPP78
CAY10618
|
NAMPT
Autophagy
|
Cancer
Inflammation/Immunology
|
GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.
|
-
- HY-14904A
-
Umifenovir hydrochloride
|
Influenza Virus
SARS-CoV
|
Infection
|
Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity.
|
-
- HY-15505
-
RWJ-67657
JNJ 3026582
|
p38 MAPK
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11 μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effect. Anti-inflammatory and anti-tumor activity.
|
-
- HY-130605
-
BAY-1797
|
P2X Receptor
|
Neurological Disease
|
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects.
|
-
- HY-N0261
-
Aurantio-obtusin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae, with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator. Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases.
|
-
- HY-N1584
-
-
- HY-B0715S
-
Pentoxifylline-d6
|
Phosphodiesterase (PDE)
Autophagy
HIV
|
Cardiovascular Disease
Cancer
|
Pentoxifylline-d6 (BL-191-d6) is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
|
-
- HY-135646
-
Eleutheroside B1
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.
|
-
- HY-N0674A
-
Dehydrocorydaline chloride
13-Methylpalmatine chloride
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-B0715S2
-
Pentoxifylline-4′,4′,6′,6′,6′-d5
|
Phosphodiesterase (PDE)
Autophagy
HIV
|
Cardiovascular Disease
Cancer
|
Pentoxifylline-4′,4′,6′,6′,6′-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.
|
-
- HY-B1355AS1
-
-
- HY-19589
-
-
- HY-70072
-
D609
|
Phospholipase
|
Cancer
Infection
Inflammation/Immunology
|
D609, an antitumoural xanthate, is a specific and competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor with a Ki of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity.
|
-
- HY-118561
-
Bermoprofen
AD-1590
|
Others
|
Inflammation/Immunology
|
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits.
|
-
- HY-N0427
-
Phellodendrine
|
Akt
NF-κB
|
Inflammation/Immunology
|
Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .
|
-
- HY-N8092
-
-
- HY-122521
-
Sootepin D
|
NF-κB
|
Inflammation/Immunology
|
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC50 of 8.3μM. Sootepin D has anti-inflammatory activity.
|
-
- HY-N1082
-
-
- HY-116213
-
-
- HY-113772
-
Inflachromene
|
Others
|
Inflammation/Immunology
Neurological Disease
|
Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders.
|
-
- HY-N1782
-
-
- HY-N10106
-
-
- HY-A0213
-
Tiludronate
Tiludronic acid
|
Proton Pump
|
Inflammation/Immunology
|
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-112706
-
PF-06747711
|
ROR
|
Inflammation/Immunology
|
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity.
|
-
- HY-N1506
-
Ganodermanontriol
|
Others
|
Cancer
|
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity.
|
-
- HY-106050
-
Tilomisole
Wy 18251
|
Others
|
Cancer
Inflammation/Immunology
|
Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation.
|
-
- HY-145684
-
-
- HY-130285
-
-
- HY-121192
-
-
- HY-N0301
-
Thiocolchicoside
|
GABA Receptor
|
Inflammation/Immunology
Neurological Disease
|
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.
|
-
- HY-N0120A
-
Polydatin
Piceid
|
Autophagy
Apoptosis
Mitophagy
|
Inflammation/Immunology
Cancer
|
Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
|
-
- HY-135303
-
GLPG1205
|
GPR84
|
Inflammation/Immunology
|
GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.
|
-
- HY-B0493S1
-
-
- HY-147264
-
Edecesertib
GS-5718
|
IRAK
|
Inflammation/Immunology
|
Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research.
|
-
- HY-N0364
-
-
- HY-N4134
-
Ciwujianoside C3
|
NO Synthase
|
Inflammation/Immunology
|
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory.
|
-
- HY-13693S1
-
Mometasone furoate-d8
Sch32088-d8
|
Glucocorticoid Receptor
|
Inflammation/Immunology
Endocrinology
|
Mometasone furoate-d8 (Sch32088-d8) is the deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo
|
-
- HY-17002
-
Suplatast (Tosilate)
IPD 1151T
|
Interleukin Related
|
Inflammation/Immunology
|
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity.
|
-
- HY-12554
-
Terlipressin
|
Vasopressin Receptor
|
Endocrinology
Inflammation/Immunology
Cardiovascular Disease
|
Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
|
-
- HY-N0292
-
Oleuropein
|
PPAR
Apoptosis
Aromatase
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity. Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase.
|
-
- HY-147742
-
Thi-DPPY
|
JAK
|
Inflammation/Immunology
|
Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF).
|
-
- HY-12554A
-
Terlipressin acetate
|
Vasopressin Receptor
|
Endocrinology
Inflammation/Immunology
Cardiovascular Disease
|
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
|
-
- HY-N0587
-
Demethylzeylasteral
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities. Demethylzeylasteral can significantly alleviates atherosclerosis (AS). Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.
|
-
- HY-12511
-
SKF-86002
|
p38 MAPK
|
Inflammation/Immunology
|
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
|
-
- HY-B0578B
-
Loxoprofen sodium (dihydrate)
|
COX
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity.
|
-
- HY-W127758
-
Alginic acid
|
Histamine Receptor
Apoptosis
Autophagy
|
Endocrinology
Inflammation/Immunology
|
Alginic acid is a natural polysaccharide, which has been widely concerned and applied due to its excellent water solubility, film formation, biodegradability and biocompatibility. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Alginic acid has an inhibitory effect on histamine release. Anti-anaphylactic and anti-inflammatory properties.
|
-
- HY-P2268A
-
RAGE antagonist peptide TFA
|
Amyloid-β
|
Cancer
Inflammation/Immunology
|
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities.
|
-
- HY-108641
-
SKF-86002 dihydrochloride
|
p38 MAPK
|
Inflammation/Immunology
|
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
|
-
- HY-10582S
-
Flurbiprofen-d3
dl-Flurbiprofen-d3
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
Flurbiprofen-d3 (dl-Flurbiprofen-d3) is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
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-
- HY-10582S1
-
Flurbiprofen-d5
dl-Flurbiprofen-d5
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
Flurbiprofen-d5 (dl-Flurbiprofen-d5) is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
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-
- HY-N0631
-
Cornuside
|
p38 MAPK
NF-κB
|
Inflammation/Immunology
|
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases.
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-
- HY-10582S2
-
Flurbiprofen-13C,d3
dl-Flurbiprofen-13C,d3
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
Flurbiprofen-13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
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-
- HY-13568
-
Benoxaprofen
LRCL 3794
|
COX
|
Inflammation/Immunology
|
Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation.
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-
- HY-P1050
-
COG 133
|
nAChR
|
Inflammation/Immunology
Neurological Disease
|
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM.
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-
- HY-147815
-
COX-2-IN-21
|
COX
|
Inflammation/Immunology
|
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential.
|
-
- HY-N2255
-
-
- HY-17043
-
-
- HY-B1276
-
-
- HY-A0221
-
Ridogrel
R 68070
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities.
|
-
- HY-106139
-
Bimosiamose
TBC-1269
|
Others
|
Inflammation/Immunology
|
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.
|
-
- HY-N0836
-
Jervine
11-Ketocyclopamine
|
Hedgehog
Smo
|
Cancer
Inflammation/Immunology
|
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.
|
-
- HY-W040265
-
Fenamic acid
N-Phenylanthranilic acid
|
Chloride Channel
|
Inflammation/Immunology
|
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent -.
|
-
- HY-78131BS
-
(R)-(-)-Ibuprofen-d3
(R)-Ibuprofen-d3
|
NF-κB
|
Inflammation/Immunology
Cancer
|
(R)-(-)-Ibuprofen-d3 ((R)-Ibuprofen-d3) is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
|
-
- HY-120628
-
BMS-587101
|
Integrin
|
Inflammation/Immunology
|
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.
|
-
- HY-A0213A
-
Tiludronate disodium
Tiludronic acid disodium
|
Proton Pump
|
Inflammation/Immunology
|
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-17609
-
Difelikefalin
CR-845; FE-202845
|
Opioid Receptor
|
Neurological Disease
|
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.
|
-
- HY-B0298A
-
-
- HY-13580
-
Budesonide
|
Glucocorticoid Receptor
|
Cancer
Inflammation/Immunology
|
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
|
-
- HY-B1227
-
-
- HY-N2191
-
Ecliptasaponin D
|
Others
|
Inflammation/Immunology
|
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba (L.) Hassk which is the aerial part of Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant and immunomodulatory[1,2].
|
-
- HY-N0003
-
Honokiol
NSC 293100
|
Akt
Autophagy
HCV
ERK
|
Cancer
|
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier.
|
-
- HY-B0260S2
-
-
- HY-N1023
-
-
- HY-N7696
-
Physalin F
|
Apoptosis
|
Inflammation/Immunology
|
Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection.
|
-
- HY-B1616S
-
Clobetasone butyrate-d7
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
Clobetasone butyrate-d7 is the deuterium labeled Clobetasone butyrate. Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.
|
-
- HY-105174
-
BPC 157
|
Endogenous Metabolite
|
Inflammation/Immunology
|
BPC 157 is a stable gastric pentadecapeptide and a partial sequence of the human gastric juice protein BPC. BPC 157 is an anti-ulcer peptidergic agent with no reported toxicity. BPC 157 links inflammatory bowel disease and multiple sclerosis.
|
-
- HY-136177
-
-
- HY-B0260S3
-
-
- HY-N0103A
-
Sophocarpine monohydrate
|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
|
Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.
|
-
- HY-N0103
-
Sophocarpine
|
Autophagy
Apoptosis
PI3K
Akt
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
|
Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.
|
-
- HY-N1584A
-
-
- HY-N1429S2
-
Taurochenodeoxycholic acid-d4-1 sodium
12-Deoxycholyltaurine-d4-1 sodium
|
Apoptosis
Endogenous Metabolite
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
|
-
- HY-N7656
-
5,7,8-Trimethoxyflavone
Norwogonin 5,7,8-trimethyl ether
|
Others
|
Inflammation/Immunology
|
5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity.
|
-
- HY-14882
-
Cenicriviroc
TAK-652; TBR-652
|
CCR
HIV
|
Infection
Endocrinology
|
Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
|
-
- HY-B0260S4
-
Methylprednisolone-d2
U 7532-d2
|
Glucocorticoid Receptor
Autophagy
SARS-CoV
|
Others
|
Methylprednisolone-d2 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
|
-
- HY-B0336
-
Pranoprofen
|
COX
Apoptosis
PGE synthase
|
Cancer
Inflammation/Immunology
|
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
|
-
- HY-N6810
-
Thymol
|
Bacterial
|
Infection
Inflammation/Immunology
|
Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
|
-
- HY-N0608A
-
(Rac)-Myrislignan
|
NF-κB
|
Inflammation/Immunology
|
(Rac)-Myrislignan is the racemate of Myrislignan. Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.
|
-
- HY-14398S1
-
Celecoxib-d3
SC 58635-d3
|
COX
|
Inflammation/Immunology
Cancer
|
Celecoxib-d3 (SC 58635-d3) is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.
|
-
- HY-14398S
-
Celecoxib-d7
SC 58635-d7
|
COX
|
Inflammation/Immunology
Cancer
|
Celecoxib-d7 (SC 58635-d7) is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.
|
-
- HY-119447
-
Mavacoxib
|
COX
|
Inflammation/Immunology
|
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs.
|
-
- HY-17461
-
-
- HY-78131S1
-
Ibuprofen-13C,d3
(±)-Ibuprofen-13C,d3
|
COX
|
Inflammation/Immunology
Cancer
|
Ibuprofen-13C,d3 is the 13C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-N6007
-
-
- HY-12122A
-
-
- HY-N0006S
-
Demethoxycurcumin-d7
Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7
|
Apoptosis
Autophagy
Bacterial
|
Inflammation/Immunology
Cancer
|
Demethoxycurcumin-d7 (Curcumin II-d7) is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
|
-
- HY-A0158
-
Diflorasone
|
Others
|
Inflammation/Immunology
|
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis.
|
-
- HY-N8085
-
Icariside F2
|
NF-κB
|
Inflammation/Immunology
|
Icariside F2 is a potent NF-κB inhibitor with an IC50 value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity.
|
-
- HY-N0063
-
Punicalagin
|
SARS-CoV
HBV
|
Cancer
Infection
Metabolic Disease
|
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19.
|
-
- HY-107818
-
4-Hydroxychalcone
|
NF-κB
|
Inflammation/Immunology
Cardiovascular Disease
|
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice.
|
-
- HY-P1306A
-
Obestatin(rat) TFA
|
GHSR
|
Inflammation/Immunology
Cardiovascular Disease
|
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
|
-
- HY-14904
-
Umifenovir
|
SARS-CoV
Influenza Virus
|
Infection
|
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.
|
-
- HY-N0482
-
-
- HY-N1029
-
Norathyriol
Mangiferitin
|
Glucosidase
PPAR
|
Cancer
Infection
Inflammation/Immunology
|
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
|
-
- HY-105231
-
Bryostatin 1
|
PKC
HIV
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.
|
-
- HY-N4238
-
Dehydrocorydaline nitrate
13-Methylpalmatine nitrate
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-107569
-
-
- HY-N0166
-
-
- HY-N0674
-
Dehydrocorydaline
13-Methylpalmatine
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Cancer
Infection
|
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-13571AS1
-
-
- HY-B1799A
-
Tolmetin sodium
|
COX
|
Cancer
Inflammation/Immunology
|
Tolmetin sodium is an orally active and potent COX inhibitor with IC50s of 0.35 µM and 0.82 µM human COX-1 and COX-2, respectively. Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID).
|