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Results for "

anti-HIV-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (33) HIV Protease (5) Autophagy (3) Bacterial (4) CCR (2) CXCR (1) DNA/RNA Synthesis (2) Fungal (1) HBV (1) IKK (2) Influenza Virus (2) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Parasite (2) PKC (1) Reverse Transcriptase (3)
By Research Areas:	Cancer (6) Infection (37) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0052A

Enfuvirtide acetate

2 Publications Verification

T20 acetate; DP178 acetate
HIV Infection

Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.
HY-P0052

Enfuvirtide

2 Publications Verification

T20; DP178
HIV Infection

Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

Enfuvirtide acetate 2 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

Enfuvirtide 2 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-N12345

5-Dexyexcoecafolin B	Others	Others
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC₅₀ value of 0.036 μM ^[1].

HY-N3094

Periglaucine A	HBV HIV	Infection
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) ^[1].

HY-144731

gp120-IN-2	HIV	Inflammation/Immunology
gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 7.5 µM and CC₅₀ of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells ^[1].

HY-N1352

Rhuscholide A

Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM ^[1].

Rhuscholide A
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM ^[1].

HY-N10958

Wikstrol A	Fungal HIV Microtubule/Tubulin	Infection
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM ^[1].

HY-144730

gp120-IN-1	HIV	Inflammation/Immunology
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 2.2 µM and CC₅₀ of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells ^[1].

HY-N0556

Isoescin IA

HIV Protease Infection

Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].
HY-N10934

Ganoderic acid GS-1

HIV Protease Infection

Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM ^[1].

Isoescin IA	HIV Protease	Infection
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

Ganoderic acid GS-1	HIV Protease	Infection
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM ^[1].

HY-N12046

Schineolignin B	HIV	Infection Inflammation/Immunology Cancer
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-N12047

Schineolignin C	HIV	Infection Inflammation/Immunology Cancer
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity ^[1].

HY-126924

(Rac)-Saphenamycin

HIV Infection

(Rac)-Saphenamycin (compound CID_134184) is a gp41 inhibitor with anti-HIV-1 activity. (Rac)-Saphenamycin reveals p-p interactions with Trp571 ^[1].

(Rac)-Saphenamycin	HIV	Infection
(Rac)-Saphenamycin (compound CID_134184) is a gp41 inhibitor with *anti-HIV-1* activity. (Rac)-Saphenamycin reveals p-p interactions with Trp571 ^[1].

HY-113818

Kadsuracoccinic acid A	HIV	Infection
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro *anti-HIV-1* activitiy with an EC₅₀ value of 68.7 μM ^[1].

HY-N3502

20(21)-Dehydrolucidenic acid A	HIV Protease	Infection
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity ^[1].

HY-152131

CCR5 antagonist 2

CCR HIV Infection

CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC₅₀ of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities ^[1].
HY-152132

CCR5 antagonist 3

CCR HIV Infection

CCR5 antagonist 3 (Compound 26) is a CCR5 antagonist with an IC₅₀ of 15.90 nM. CCR5 antagonist 3 shows broad-spectrum anti-HIV-1 activities ^[1].

CCR5 antagonist 2	CCR HIV	Infection
CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC₅₀ of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities ^[1].

CCR5 antagonist 3	CCR HIV	Infection
CCR5 antagonist 3 (Compound 26) is a CCR5 antagonist with an IC₅₀ of 15.90 nM. CCR5 antagonist 3 shows broad-spectrum anti-HIV-1 activities ^[1].

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-N2010

Methyl gallate 1 Publications Verification Gallincin; NSC 363001
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and *HIV-1* enzyme inhibitory activities.

HY-N0867

13-Oxyingenol-13-dodecanoate	HIV	Infection
13-Oxyingenol-13-dodecanoate is an ester that can be isolated from Euphorbia kansui. 13-Oxyingenol-13-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM ^[1].

HY-12687S

Tizoxanide-d4	Isotope-Labeled Compounds Bacterial HIV Autophagy	Infection
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

HY-N10801

Salvianan A

HIV Infection

1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent anti-HIV-1 agent ^[1].

Salvianan A	HIV	Infection
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent *anti-HIV-1* agent ^[1].

HY-19851

Rovafovir etalafenamide GS-9131
Rovafovir etalafenamide (GS-9131), a proagent of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity ^[1] .

HY-18666

D77	HIV	Infection
D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum ^[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-104012

Islatravir MK-8591	HIV Reverse Transcriptase	Infection
Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC₅₀s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-105231

Bryostatin 1 1 Publications Verification	PKC HIV Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of *Munc13-1* and the full-length *Munc13-1* protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties ^[1] .

HY-116528

GCA-186	HIV	Infection
GCA-186 is a potent *anti-HIV-1* agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC₅₀s of 1, 180, 1, and 40 nM for III_B, III_B-R(Y181C), NL4-3 and NL4-3_K103N of HIV-1 strains, respectively ^[1].

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection ^[1] .

HY-125810

4'-Ethynyl-2'-deoxyadenosine	HIV Reverse Transcriptase	Infection Inflammation/Immunology
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity ^[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N6924

Zingibroside R1	HIV	Infection Metabolic Disease
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity ^[1]. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-12687

Tizoxanide Maximum Cited Publications 7 Publications Verification TIZ	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells ^[1] .

HY-12687R

Tizoxanide (Standard) TIZ (Standard)	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (Standard) is the analytical standard of Tizoxanide. This product is intended for research and analytical applications. Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells ^[1] .

HY-146753

HIV-1 inhibitor-20

HIV Infection

HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles ^[1].
HY-P1757

HIV p17 Gag (77-85)

HIV Infection

HIV p17 Gag (77-85) is an HLA-A*0201(A2)-restricted CTL epitope, used in the research of anti-HIV .

HIV-1 inhibitor-20	HIV	Infection
HIV-1 inhibitor-20 is a potent *HIV-1* inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles ^[1].

HIV p17 Gag (77-85)	HIV	Infection
HIV p17 Gag (77-85) is an HLA-A0201(A2)-restricted CTL epitope, used in the research of anti-HIV .*

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	HIV	Infection
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity ^[1].

HY-146053

CXCR4 modulator-1	CXCR	Infection Inflammation/Immunology Cancer
CXCR4 modulator-1 (compound ZINC72372983) is a potent CXCR4 modulator with an EC₅₀ value of 100 nM. CXCR4 modulator-1 can be used for researching anti-inflammatory, anticancer and anti-HIV .

HY-147650

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants ^[1].

HY-143273

DENV-IN-6	HIV DNA/RNA Synthesis	Infection
DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC₅₀s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1_IIIB (EC₅₀=0.0181 µM; CC₅₀=64.92 µM) ^[1].

HY-N11288

Methyl salvionolate A	HIV	Infection
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively ^[1].

HY-150599

HIV-1 inhibitor-43	HIV DNA/RNA Synthesis	Infection
HIV-1 inhibitor-43 is a potent *HIV-1* inhibitor with an EC₅₀ of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression ^[1].

HY-144112

HIV-1 inhibitor-13	HIV	Infection
HIV-1 inhibitor-13 (compound 16c) is a orally active and potent *HIV-1* non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC₅₀ of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of *HIV-1* resistant strains, with EC₅₀ values of 2.85-18.0 nM ^[1].

Enfuvirtide acetate 2 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

Enfuvirtide 2 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Source classification Plants Disease Research Fields	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity ^[1].

HY-N12345

5-Dexyexcoecafolin B	Triterpenes Structural Classification Excoecaria acertiflia Didr Terpenoids Source classification Euphorbiaceae Plants	Others
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC₅₀ value of 0.036 μM ^[1].

HY-N3094

Periglaucine A	Structural Classification Alkaloids Pyrrole Alkaloids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz.	HBV HIV
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) ^[1].

HY-N10958

Wikstrol A	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM ^[1].

HY-N10934

Ganoderic acid GS-1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM ^[1].

HY-N12046

Schineolignin B	Structural Classification Monophenols Source classification Phenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-N12047

Schineolignin C	Structural Classification Source classification Phenols Polyphenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities ^[1].

HY-113818

Kadsuracoccinic acid A	Structural Classification Natural Products Source classification Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	HIV
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro *anti-HIV-1* activitiy with an EC₅₀ value of 68.7 μM ^[1].

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity ^[1].

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields	HIV
13-Oxyingenol-13-dodecanoate is an ester that can be isolated from Euphorbia kansui. 13-Oxyingenol-13-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM ^[1].

HY-N10801

Salvianan A	Structural Classification Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Magnoliaceae Phenols Diterpenoids Plants	HIV
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent *anti-HIV-1* agent ^[1].

HY-N2996

Ganodermanondiol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum ^[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-105231

Bryostatin 1 1 Publications Verification	Structural Classification Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Source classification Marine natural products Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of *Munc13-1* and the full-length *Munc13-1* protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties ^[1] .

HY-N6924

Zingibroside R1	Infection Classification of Application Fields Source classification Panax japonicas C. A. Mey. Metabolic Disease Plants Disease Research Fields Panax notoginseng Saccharides Araliaceae	HIV
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity ^[1]. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Eriobotrya japonica (Thunb.) Lindl.	HIV
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity ^[1].

HY-N11288

Methyl salvionolate A	Structural Classification Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively ^[1].

Cat. No.	Product Name	Chemical Structure

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

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anti-HIV-1

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