Search Result

Results for "

anti-inflammation

" in MCE Product Catalog:

By Targets:	ADC Cytotoxin (1) Adrenergic Receptor (6) Akt (3) AMPK (2) Amyloid-β (1) Apoptosis (22) Arginase (1) ATP Citrate Lyase (2) Autophagy (12) Bacterial (14) Bcl-2 Family (3) Caspase (3) Cholinesterase (ChE) (2) COX (4) Cytochrome P450 (1) EGFR (2) Endogenous Metabolite (7) Estrogen Receptor/ERR (1) Ferroptosis (1) Fungal (1) FXR (3) GCGR (3) Glucosidase (2) HBV (1) HIF/HIF Prolyl-Hydroxylase (2) HSP (1) Influenza Virus (2) Interleukin Related (4) JAK (2) JNK (1) Keap1-Nrf2 (1) Lipoxygenase (2) MDM-2/p53 (1) Mitophagy (1) MMP (3) mTOR (2) Necroptosis (1) NF-κB (7) NO Synthase (2) NOD-like Receptor (NLR) (2) Notch (1) Opioid Receptor (1) p38 MAPK (1) Parasite (2) PARP (2) PKA (1) PKC (2) Prostaglandin Receptor (1) Proton Pump (5) PTEN (1) Reactive Oxygen Species (10) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROR (1) Sirtuin (2) Somatostatin Receptor (1) STAT (1) TNF Receptor (4) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Cancer (42) Cardiovascular Disease (9) Endocrinology (13) Infection (19) Inflammation/Immunology (59) Metabolic Disease (10) Neurological Disease (10)

By Targets:

ADC Cytotoxin (1)

Adrenergic Receptor (6)

Akt (3)

AMPK (2)

Amyloid-β (1)

Apoptosis (22)

Arginase (1)

ATP Citrate Lyase (2)

Autophagy (12)

Bacterial (14)

Bcl-2 Family (3)

Caspase (3)

Cholinesterase (ChE) (2)

COX (4)

Cytochrome P450 (1)

EGFR (2)

Endogenous Metabolite (7)

Estrogen Receptor/ERR (1)

Ferroptosis (1)

Fungal (1)

FXR (3)

GCGR (3)

Glucosidase (2)

HBV (1)

HIF/HIF Prolyl-Hydroxylase (2)

HSP (1)

Influenza Virus (2)

Interleukin Related (4)

JAK (2)

JNK (1)

Keap1-Nrf2 (1)

Lipoxygenase (2)

MDM-2/p53 (1)

Mitophagy (1)

MMP (3)

mTOR (2)

Necroptosis (1)

NF-κB (7)

NO Synthase (2)

NOD-like Receptor (NLR) (2)

Notch (1)

Opioid Receptor (1)

p38 MAPK (1)

Parasite (2)

PARP (2)

PKA (1)

PKC (2)

Prostaglandin Receptor (1)

Proton Pump (5)

PTEN (1)

Reactive Oxygen Species (10)

Ribosomal S6 Kinase (RSK) (1)

RIP kinase (1)

ROR (1)

Sirtuin (2)

Somatostatin Receptor (1)

STAT (1)

TNF Receptor (4)

TRP Channel (1)

Tyrosinase (1)

By Research Areas:

Cancer (42)

Cardiovascular Disease (9)

Endocrinology (13)

Infection (19)

Inflammation/Immunology (59)

Metabolic Disease (10)

Neurological Disease (10)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-U00094

INO5042
Others Inflammation/Immunology

INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity.
HY-146748

Sorbicillin
Others Inflammation/Immunology

Sorbicillin, a sorbicillinoid analogue, acts as a potent anti-inflammation agent.

INO5042	Others	Inflammation/Immunology
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity.

Sorbicillin	Others	Inflammation/Immunology
Sorbicillin, a sorbicillinoid analogue, acts as a potent anti-inflammation agent.

HY-137988

Palvanil	TRP Channel	Inflammation/Immunology Neurological Disease
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.

HY-N3074

Hexahydrofarnesyl acetone 6,10,14-Trimethyl-2-pentadecanone	Bacterial	Infection Inflammation/Immunology
Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone), a sesquiterpene isolated from Impatiens parviflora, is the major constituents of the essential oil. Hexahydrofarnesyl acetone has antibacterial, anti-nociceptive and anti-inflammation activities.

HY-N0418

Quercitrin Quercetin 3-rhamnoside	Ribosomal S6 Kinase (RSK) Apoptosis Autophagy Reactive Oxygen Species	Inflammation/Immunology Neurological Disease Cardiovascular Disease
Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research.

HY-17503

Metoprolol	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-17503B

Metoprolol tartrate	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-17503A

Metoprolol succinate	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-N0520

Calycosin-7-O-β-D-glucoside Calycosin-7-glucoside	Reactive Oxygen Species	Others
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects.

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-N0519

Calycosin
Cyclosin
Apoptosis Cancer

Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.

Calycosin Cyclosin	Apoptosis	Cancer
Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.

HY-N3417

Kongensin A	HSP RIP kinase Apoptosis Necroptosis	Cancer Inflammation/Immunology
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.

HY-122930

Lysicamine
Bacterial Cancer Infection Inflammation/Immunology

Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity.
HY-112868B

ABH hydrochloride
Arginase Inflammation/Immunology

ABH (hydrochloride) is a potent arginase inhibitor. ABH (hydrochloride) can be used for researching anti-inflammation.

Lysicamine	Bacterial	Cancer Infection Inflammation/Immunology
Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity.

ABH hydrochloride	Arginase	Inflammation/Immunology
ABH (hydrochloride) is a potent arginase inhibitor. ABH (hydrochloride) can be used for researching anti-inflammation.

HY-W009156

Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite	Cancer Infection Metabolic Disease Inflammation/Immunology
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

HY-B1295

Lithium citrate tetrahydrate Litarex tetrahydrate	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite	Cancer Infection Metabolic Disease Inflammation/Immunology
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

HY-N0318

Salvianolic acid A
MMP Inflammation/Immunology

Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

Salvianolic acid A	MMP	Inflammation/Immunology
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-N2343

Procyanidin A2	Bacterial	Cancer Infection Inflammation/Immunology
Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity.

HY-17389

Genipin (+)-Genipin	Autophagy	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.

HY-N0709

Coumarin	Influenza Virus	Cancer Infection Inflammation/Immunology
Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

HY-14615

[6]-Gingerol (S)-(+)-[6]Gingerol; 6-Gingerol	AMPK Apoptosis	Cancer
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-N6998

Paederosidic acid	Apoptosis	Cancer
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.

HY-B0299

Oxibendazole	Parasite Apoptosis	Infection
Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein.

HY-14616

Shogaol [6]-Shogaol; 6-Shogaol	Autophagy	Cancer
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-N5040

Ilexhainanoside D	Others	Inflammation/Immunology
Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect.

HY-N7576

Anemarrhenasaponin Ia	Reactive Oxygen Species	Inflammation/Immunology
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent.

HY-113099

Indolelactic acid Indole-3-lactic acid	Endogenous Metabolite	Inflammation/Immunology
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.

HY-N0332

Ziyuglycoside II	Reactive Oxygen Species Apoptosis	Cancer Inflammation/Immunology
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect.

HY-12222

Obeticholic acid INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid	FXR Autophagy	Others
Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC₅₀ of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.

HY-N0709S

Coumarin-d4	Influenza Virus	Cancer Infection Inflammation/Immunology
Coumarin-d₄ is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

HY-N10764

Acetylexidonin	Others	Cancer
Acetylexidonin is a diterpenoid compound with anti-inflammation and cancer activity. Acetylexidonin inhibits tumor cells with IC₅₀s of 3.69 μM (NB4) and 26.22 μM (SHSY5Y), respectively.

HY-N0405

Orientin	Others	Cancer Neurological Disease
Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain.

HY-117652

Lobetyol	Apoptosis Bcl-2 Family MDM-2/p53	Cancer Infection Inflammation/Immunology
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity.

HY-N6968

α-Humulene Humulene; α-Caryophyllene	NO Synthase COX	Inflammation/Immunology
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 µg/mL). α-Humulene inhibits COX-2 and iNOS expression.

HY-17503AS

Metoprolol-d7 hydrochloride	Adrenergic Receptor	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-12222S1

Obeticholic Acid-d4	FXR Autophagy	Others
Obeticholic Acid-d₄ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-17503BS

Metoprolol-d6 tartrate	Adrenergic Receptor	Cancer Infection Endocrinology Cardiovascular Disease
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-12222S

Obeticholic acid-d5 INT-747-d₅; 6-ECDCA-d₅; 6-Ethylchenodeoxycholic acid-d₅	FXR Autophagy	Others
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-145854

GA-O-06	Bacterial	Infection Inflammation/Immunology
GA-O-06, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-06 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-06 displays a high antimicrobial activity against Gram-positive bacteria.

HY-145853

GA-O-02	Bacterial	Infection Inflammation/Immunology
GA-O-02, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-02 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-02 displays a high antimicrobial activity against Gram-positive bacteria.

HY-107454

OSS_128167	Sirtuin HBV	Cancer Infection Metabolic Disease Inflammation/Immunology
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-acncer, anti-inflammation and anti-viral effects.

HY-N0155

Nobiletin	ROR Reactive Oxygen Species Apoptosis Autophagy	Cancer Inflammation/Immunology Neurological Disease
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.

HY-145532

S-Allylmercaptocysteine	Apoptosis NF-κB Keap1-Nrf2	Cancer Inflammation/Immunology
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation.

HY-N6947

Lutein Xanthophyll	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Inflammation/Immunology Neurological Disease
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Cancer Inflammation/Immunology
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.

HY-N0164

Matrine Matridin-15-one; Vegard; α-Matrine	Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis	Cancer Inflammation/Immunology
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).

HY-P3841

Protein Kinase C (beta) Peptide	PKC	Others
Protein Kinase C β Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia.

HY-N0281

Daphnetin 7,8-Dihydroxycoumarin	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

HY-147733

sEH inhibitor-5
Cholinesterase (ChE) Inflammation/Immunology

sEH inhibitor-5 (compound D016) is a potent sEH (soluble epoxide hydrolase) inhibitor with an IC₅₀ value of 0.1 nM.
HY-147119

INX-SM-6
ADC Cytotoxin Inflammation/Immunology

INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS.

HY-N0044

Ginsenoside Re Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Inflammation/Immunology Neurological Disease Cancer
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N1356

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

HY-N7640

Deoxylimonin	Others	Cancer Inflammation/Immunology
Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound.

HY-N0928

Mimosine	Apoptosis	Cancer Inflammation/Immunology
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.

HY-N2181

Acetylshikonin	Cytochrome P450 Cholinesterase (ChE) Apoptosis	Cancer Inflammation/Immunology
Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC₅₀ values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.

HY-133747

JAK3-IN-9	JAK	Inflammation/Immunology
JAK3-IN-9 is an orally active JAK3 inhibitor with IC₅₀ value of 1.7 nM. JAK3-IN-9 is highly selective to the JAK3 signal path. JAK3-IN-9 is lowly toxic with high oral bioavailability, shows good *anti-arthritis* activity. JAK3-IN-9 can be used in autoimmune disease research.

HY-N8152

Randialic acid B	Reactive Oxygen Species	Inflammation/Immunology
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo.

HY-N0493

Pectolinarigenin	COX Lipoxygenase	Inflammation/Immunology
Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity. Pectolinarigenin has potent inhibitory activities on melanogenesis.

HY-147562

ALPK1-IN-2	NF-κB	Cancer Inflammation/Immunology
ALPK1-IN-2 (compound T001) is a potent ALPK1 (alpha-kinase 1) inhibitor, with an IC₅₀ of 95 nM. ALPK1-IN-2 also inhibits NF-κB, with an IC₅₀ of 1.31 μM.

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Glucosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent *anti-inflammatory* agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear.

HY-17021C

Esomeprazole hemistrontium (S)-Omeprazole hemistrontium; (-)-Omeprazole hemistrontium	Proton Pump Bacterial	Cancer Endocrinology Inflammation/Immunology
Esomeprazole ((S)-Omeprazole) hemistrontium is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole hemistrontium has the potential for symptomatic gastroesophageal reflux disease research.

HY-N10440

3-Oxo-hop-22(29)-ene	Glucosidase	Infection Inflammation/Immunology
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.

HY-17021B

Esomeprazole potassium salt (S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt	Proton Pump Bacterial	Cancer Endocrinology Inflammation/Immunology
Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole potassium salt has the potential for symptomatic gastroesophageal reflux disease research.

HY-17021A

Esomeprazole magnesium salt (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt	Proton Pump Bacterial	Cancer Endocrinology Inflammation/Immunology
Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole magnesium salt has the potential for symptomatic gastroesophageal reflux disease research.

HY-N6643

Rubropunctamine	Fungal Bacterial	Infection Inflammation/Immunology
Rubropunctamine is a redMonascus pigment. Not only Rubropunctamine exerts antibiotic action against bacteria but also against some yeast and filamentous fungi strains. Rubropunctamine has potential embryotoxicity and teratogenicity.

HY-17021

Esomeprazole (S)-Omeprazole; (-)-Omeprazole	Proton Pump Bacterial	Cancer Endocrinology Inflammation/Immunology
Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.

HY-17023

Esomeprazole sodium (S)-Omeprazole sodium; (-)-Omeprazole sodium	Proton Pump Bacterial	Endocrinology Cancer
Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H⁺-ATPases. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.

HY-N10436

Anti-inflammatory agent 30
Others Metabolic Disease Inflammation/Immunology

Anti-inflammatory agent 30 (Compound 5) is an anti-inflammatory agent with hepatoprotective activity.
HY-N10435

Anti-inflammatory agent 29
Others Metabolic Disease Inflammation/Immunology

Anti-inflammatory agent 29 (Compound 7) is an anti-inflammatory agent with hepatoprotective activity.
HY-N10434

Anti-inflammatory agent 28
Others Metabolic Disease Inflammation/Immunology

Anti-inflammatory agent 28 (Compound 9) is an anti-inflammatory agent with hepatoprotective activity.

HY-W016412

Coenzyme Q0 CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Cancer Inflammation/Immunology Neurological Disease
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.

HY-N9975

4'',5''-Dehydroisopsoralidin	Others	Cancer Inflammation/Immunology
4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM. CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively. CH 275 can be used for the research of alzheimer’s disease.

HY-10405

Pamapimod Ro4402257; R1503	p38 MAPK Autophagy	Inflammation/Immunology
Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC₅₀s of 14 nM and 480 nM and K_is of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Endocrinology Inflammation/Immunology
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-N0633

Muscone	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology Cardiovascular Disease
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

HY-N0232

Psoralidin	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.

HY-151343

NLRP3-IN-10	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC₅₀ value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formation.

HY-12452

DPN Diarylpropionitrile	Estrogen Receptor/ERR Apoptosis Autophagy	Neurological Disease
DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC₅₀ of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases.

HY-A0096

Iloprost Ciloprost; ZK 36374	Prostaglandin Receptor Endogenous Metabolite	Endocrinology Cancer
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

HY-P1731

Tirzepatide LY3298176	GCGR	Metabolic Disease
Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

HY-P1731B

Tirzepatide hydrochloride LY3298176 hydrochloride	GCGR	Metabolic Disease
Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

HY-P1731A

Tirzepatide TFA LY3298176 TFA	GCGR	Metabolic Disease
Tirzepatide TFA (LY3298176 TFA) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

Cat. No.	Product Name

HY-L026

Clinical Compound Library

1957 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, such as lower risk and less investment. Clinical drugs have confirmed bioactivities, clear mechanisms and high safety that are suitable for drug repurposing.

MCE owns a unique collection of 1957 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc.

HY-L026P

Clinical Compound Library Plus

2236 compounds

MCE owns a unique collection of 2236 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc. Clinical Compound Library Plus, with powerful screening capability, further complements Clinical Compound Library (HY-L026) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Cat. No.	Product Name	Type

HY-B1295

Lithium citrate tetrahydrate Litarex tetrahydrate	Biochemical Assay Reagents
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

HY-W016412

Coenzyme Q0

CoQ0

Biochemical Assay Reagents

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.

Cat. No.	Product Name	Target	Research Area

HY-P3841

Protein Kinase C (beta) Peptide	PKC	Others
Protein Kinase C β Peptide is a peptide fragment of Protein Kinase Cβ. Protein Kinase Cβ is related with hyperglycemia decreases endothelium-derived nitric oxide. Inhibition of Protein kinase Cβ prevents the reduction in endothelium-dependent vasodilation induced by acute hyperglycemia.

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM. CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively. CH 275 can be used for the research of alzheimer’s disease.

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Endocrinology Inflammation/Immunology
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P1731

Tirzepatide LY3298176	GCGR	Metabolic Disease
Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

HY-P1731B

Tirzepatide hydrochloride LY3298176 hydrochloride	GCGR	Metabolic Disease
Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

HY-P1731A

Tirzepatide TFA LY3298176 TFA	GCGR	Metabolic Disease
Tirzepatide TFA (LY3298176 TFA) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes.

Cat. No.	Product Name	Target	Research Area

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Cancer Inflammation/Immunology
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.

Cat. No.	Product Name	Target	Category

HY-137988

Palvanil	TRP Channel	Monophenols Capsicum annuum L. Solanaceae Plants Source classification
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.

HY-N3074

Hexahydrofarnesyl acetone 6,10,14-Trimethyl-2-pentadecanone	Bacterial	Natural Products Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants other families Balsaminaceae Impatiens parviflora DC.
Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone), a sesquiterpene isolated from Impatiens parviflora, is the major constituents of the essential oil. Hexahydrofarnesyl acetone has antibacterial, anti-nociceptive and anti-inflammation activities.

HY-N0418

Quercitrin Quercetin 3-rhamnoside	Ribosomal S6 Kinase (RSK) Apoptosis Autophagy Reactive Oxygen Species	Flavonols Phenols Polyphenols Structural Classification Flavonoids Compositae Plants Source classification Grangea maderaspatana (Linn.) Poir. Inflammation/Immunology Disease Research Fields Classification of Application Fields
Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research.

HY-17503

Metoprolol	Adrenergic Receptor Apoptosis	Classification of Application Fields Disease Research Fields Endocrinology
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.

HY-N0520

Calycosin-7-O-β-D-glucoside Calycosin-7-glucoside	Reactive Oxygen Species	Isoflavones Monophenols Phenols Structural Classification Flavonoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Leguminosae Plants Source classification Other Diseases Disease Research Fields Classification of Application Fields
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects.

HY-N0519

Calycosin Cyclosin	Apoptosis	Flavonoids Isoflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao other families
Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.

HY-N3417

Kongensin A	HSP RIP kinase Apoptosis Necroptosis	Inflammation/Immunology Disease Research Fields Classification of Application Fields Plants Euphorbiaceae Croton kongensis Gagnep.
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications.

HY-122930

Lysicamine	Bacterial	Alkaloids Isoquinoline Alkaloids Source classification Plants Annonaceae Artabotrys maingayi Hook.f. & Thomson
Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity.

HY-W009156

Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia cambogia Inflammation/Immunology Metabolic Disease Disease Research Fields Classification of Application Fields
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

HY-B1295

Lithium citrate tetrahydrate Litarex tetrahydrate	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Microorganisms Source classification Infection Disease Research Fields Classification of Application Fields
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

HY-N0318

Salvianolic acid A	MMP	Stilbenes Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Labiatae Hemistepta lyrata
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-N2343

Procyanidin A2	Bacterial	Biflavones Phenols Polyphenols Flavonoids Inflammation/Immunology Infection Functional Molecules Research of Health Products Disease Research Fields Classification of Application Fields Source classification Plants Vitaceae Vitis vinifera cv. Zalema other families
Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity.

HY-17389

Genipin (+)-Genipin	Autophagy	Terpenoids Iridoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Metabolic Disease Neurological Disease Source classification Plants Rubiaceae Gardenia jasminoides Ellis
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research.

HY-N0709

Coumarin	Influenza Virus	Coumarins Phenylpropanoids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants Umbelliferae Glehnia littoralis Fr. Schmidt ex Miq.
Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

HY-14615

[6]-Gingerol (S)-(+)-[6]Gingerol; 6-Gingerol	AMPK Apoptosis	Monophenols Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Zingiberaceae Zingiber officinale
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-N6998

Paederosidic acid	Apoptosis	Iridoids Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Rubiaceae Paederia scandens (Lour.) Merr. other families
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Structural Classification Phenols Polyphenols Source classification Plants Orchidaceae Appendicula reflexa Blume
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein.

HY-14616

Shogaol [6]-Shogaol; 6-Shogaol	Autophagy	Phenols Monophenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Zingiberaceae Zingiber officinale
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-N5040

Ilexhainanoside D	Others	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Aquifoliaceae Ilex pubescens Hook. et Arn.
Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect.

HY-N7576

Anemarrhenasaponin Ia	Reactive Oxygen Species	Steroids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Liliaceae Anemarrhena asphodeloides Bunge
Anemarrhenasaponin Ia, isolated from Anemarrhenae rhizome, inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation. Anemarrhenasaponin Ia is an useful anti-inflammation reagent.

HY-113099

Indolelactic acid Indole-3-lactic acid	Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Endogenous metabolite
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.

HY-N0332

Ziyuglycoside II	Reactive Oxygen Species Apoptosis	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rosaceae Sanguisorba officinalis Linn.
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect.

HY-N10764

Acetylexidonin	Others	Structural Classification Terpenoids Stilbenes Diterpenoids Labiatae Plants Source classification Isodon rubescens (Hemsley) H. Hara
Acetylexidonin is a diterpenoid compound with anti-inflammation and cancer activity. Acetylexidonin inhibits tumor cells with IC₅₀s of 3.69 μM (NB4) and 26.22 μM (SHSY5Y), respectively.

HY-N0405

Orientin	Others	Flavonoids Flavones Phenols Polyphenols Source classification Plants other families
Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain.

HY-117652

Lobetyol	Apoptosis Bcl-2 Family MDM-2/p53	Structural Classification Natural Products Lobelia chinensis Lour. Campanulaceae Plants Source classification
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity.

HY-N6968

α-Humulene Humulene; α-Caryophyllene	NO Synthase COX	Structural Classification Terpenoids Other Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Myristicaceae Myristica fragrans Houtt.
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 µg/mL). α-Humulene inhibits COX-2 and iNOS expression.

HY-N0155

Nobiletin	ROR Reactive Oxygen Species Apoptosis Autophagy	Flavonoids Flavones Classification of Application Fields Disease Research Fields Inflammation/Immunology Neurological Disease Source classification Plants Rutaceae Citrus reticulata Blanco
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.

HY-N6947

Lutein Xanthophyll	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Structural Classification Terpenoids Diterpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

HY-N0164

Matrine Matridin-15-one; Vegard; α-Matrine	Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis	Alkaloids Piperidine Alkaloids Biological Pesticide Research Inflammation/Immunology Disease Research Fields Cancer Agricultural Research Classification of Application Fields Source classification Plants Leguminosae Sophora flavescens
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).

HY-N0281

Daphnetin 7,8-Dihydroxycoumarin	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Coumarins Phenylpropanoids Phenols Polyphenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Thymelaeaceae Daphne
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

HY-N0044

Ginsenoside Re Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Triterpenes Terpenoids Neurological Disease Disease Research Fields Cancer Classification of Application Fields Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N1356

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Isoquinoline Alkaloids Alkaloids Phenols Polyphenols Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

HY-N7640

Deoxylimonin	Others	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Rutaceae Citrus paradisi Macf. Microorganisms
Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound.

HY-N0928

Mimosine	Apoptosis	Natural Products Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.

HY-N2181

Acetylshikonin	Cytochrome P450 Cholinesterase (ChE) Apoptosis	Quinones Naphthalene Quinones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Boraginaceae Lithospermum erythrorhizon Sieb. et Zucc.
Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin is a non-selective cytochrome P450 inhibitor against all P450s (IC₅₀ values range from 1.4-4.0 μM). Acetylshikonin is an AChE inhibitor and exhibits potent antiapoptosis activity.

HY-N8152

Randialic acid B	Reactive Oxygen Species	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Aquifoliaceae Ilex pubescens Hook. et Arn.
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo.

HY-N0493

Pectolinarigenin	COX Lipoxygenase	Flavonoids Flavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Compositae Campylotropis hirtella (Franch.) Schindl.
Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity. Pectolinarigenin has potent inhibitory activities on melanogenesis.

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Glucosidase	Terpenoids Triterpenes Source classification Plants Euphorbiaceae Cnidoscolus spinosus Lundell
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent *anti-inflammatory* agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear.

HY-N10440

3-Oxo-hop-22(29)-ene	Glucosidase	Terpenoids Triterpenes Source classification Plants Euphorbiaceae Cnidoscolus spinosus Lundell
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.

HY-N6643

Rubropunctamine	Fungal Bacterial	Inflammation/Immunology Disease Research Fields Classification of Application Fields
Rubropunctamine is a redMonascus pigment. Not only Rubropunctamine exerts antibiotic action against bacteria but also against some yeast and filamentous fungi strains. Rubropunctamine has potential embryotoxicity and teratogenicity.

HY-N10436

Anti-inflammatory agent 30	Others	Phenols Source classification Plants Umbelliferae Ligusticum chuanxiong Hort.
Anti-inflammatory agent 30 (Compound 5) is an anti-inflammatory agent with hepatoprotective activity.

HY-N10435

Anti-inflammatory agent 29	Others	Phenols Source classification Plants Umbelliferae Ligusticum chuanxiong Hort.
Anti-inflammatory agent 29 (Compound 7) is an anti-inflammatory agent with hepatoprotective activity.

HY-N10434

Anti-inflammatory agent 28	Others	Phenols Source classification Plants Umbelliferae Ligusticum chuanxiong Hort.
Anti-inflammatory agent 28 (Compound 9) is an anti-inflammatory agent with hepatoprotective activity.

HY-N9975

4'',5''-Dehydroisopsoralidin	Others	Coumarins Phenylpropanoids Structural Classification Solanaceae Solanum lyratum Thunberg Plants Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields
4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.

HY-N0633

Muscone	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Ketones, Aldehydes, Acids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Animals
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

HY-N0232

Psoralidin	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Leguminosae Psoralea corylifolia L.
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.

Cat. No.	Product Name

HY-N0709S

Coumarin-d4
Coumarin-d₄ is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

HY-17503AS

Metoprolol-d7 hydrochloride
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-12222S1

Obeticholic Acid-d4
Obeticholic Acid-d₄ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-17503BS

Metoprolol-d6 tartrate
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-12222S

Obeticholic acid-d5
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

anti-inflammation

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