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Results for "

anti-osteoporosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (2) Bcl-2 Family (1) Caspase (1) Endogenous Metabolite (1) ERK (1) JAK (1) NF-κB (3) p38 MAPK (1) PARP (1) PI3K (1) STAT (1) Wnt (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-49069

Anti-osteoporosis agent-7

Others Others

Anti-osteoporosis agent-7 (Compound 133) is a potential anti-osteoporosis agent showing high inhibition of osteoclast formation.

Anti-osteoporosis agent-7	Others	Others
Anti-osteoporosis agent-7 (Compound 133) is a potential anti-osteoporosis agent showing high inhibition of osteoclast formation.

HY-149472

Anti-osteoporosis agent-4	NF-κB PI3K	Inflammation/Immunology
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC₅₀ value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .

HY-N11514

Anti-osteoporosis agent-2	Others	Inflammation/Immunology
Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL .

HY-149852

Anti-osteoporosis agent-3	Others	Inflammation/Immunology
Anti-osteoporosis agent-3 (Compound 11), a PMSA derivative, is an anti-osteoporosis agent. Anti-osteoporosis agent-3 inhibits osteoclastogenesis with an IC₅₀ value of 322.9 nM in vitro. Anti-osteoporosis agent-3 also blocks the formation of F-action belts and bone resorption .

HY-155985

Anti-osteoporosis agent-6	Others	Metabolic Disease
Anti-osteoporosis agent-6 (compound 174) is an anti-osteoporosis agent. Anti-osteoporosis agent-6 has 14.11% inhibition rate against osteoclast formation at 10 μM .

HY-155977

Anti-osteoporosis agent-5

Others Others

Anti-osteoporosis agent-5 (compound 189) is a potent inhibitor of the formation of osteoclasts .
HY-145896

Anti-osteoporosis agent-1

Apoptosis Inflammation/Immunology

Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC₅₀=18 µM) .
HY-N10370

Morusignin L

Others Cancer

Morusignin L is an active compound that shows anti-osteoporosis activities .

Anti-osteoporosis agent-5	Others	Others
Anti-osteoporosis agent-5 (compound 189) is a potent inhibitor of the formation of osteoclasts .

Anti-osteoporosis agent-1	Apoptosis	Inflammation/Immunology
Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC₅₀=18 µM) .

Morusignin L	Others	Cancer
Morusignin L is an active compound that shows anti-osteoporosis activities .

HY-N0824

Syringin 1 Publications Verification Eleutheroside B	Autophagy	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

HY-N2290

Baohuoside VII

Others Metabolic Disease

Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities .

Baohuoside VII	Others	Metabolic Disease
Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities .

HY-N0213

Peiminine 3 Publications Verification Verticinone; Raddeanine	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis	Inflammation/Immunology Cancer
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-W009208

Calcium L-Threonate	Endogenous Metabolite	Metabolic Disease
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement . Calcium L-Threonate also stimulates the uptake of ascorbic acid .

HY-N0705

Curculigoside 5 Publications Verification	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-155960

SH491	Others	Inflammation/Immunology
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .

HY-124156

KY-02327	Wnt	Metabolic Disease
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-124156A

KY-02327 acetate	Wnt	Metabolic Disease
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-N1940

β-Anhydroicaritin 1 Publications Verification
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

Syringin 1 Publications Verification Eleutheroside B	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae	Autophagy
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .

Peiminine 3 Publications Verification Verticinone; Raddeanine	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Fritillaria thunbergii Miq. Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

Anti-osteoporosis agent-2	Structural Classification Terpenoids Sesquiterpenes Source classification Bituminaria morisiana (Pignatti & Metlesics) Greuter Plants Compositae	Others
Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL .

Morusignin L	Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Disease Research Fields Cancer	Others
Morusignin L is an active compound that shows anti-osteoporosis activities .

Baohuoside VII	Flavonols Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields	Others
Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities .

Calcium L-Threonate	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Calcium L-Threonate is an anti-osteoporosis agent, and widely used as a calcium supplement . Calcium L-Threonate also stimulates the uptake of ascorbic acid .

Curculigoside 5 Publications Verification	Curculigo orchioides Gaertn. Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Plants Disease Research Fields Amaryllidaceae Cancer	JAK STAT NF-κB
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

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anti-osteoporosis

Inhibitors & Agonists

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Natural
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