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Results for "

antibacterial activity

" in MCE Product Catalog:

396

Inhibitors & Agonists

4

Screening Libraries

11

Peptides

161

Natural
Products

29

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas
  • HY-N3789
    Dunnianol

    Bacterial Infection
    Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).
  • HY-N10210
    Saccharothrixin F

    Bacterial Infection
    Saccharothrixin F is a highly oxygenated saccharothrixin, with antibacterial and anti-inflammatory activities.
  • HY-N10281
    Asperglaucin B

    Bacterial Infection
    Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM.
  • HY-146264
    Antibacterial agent 91

    Aminoacyl-tRNA Synthetase Bacterial Infection
    Antibacterial agent 91 (Compound 36b) is a triple-site aminoacyl-tRNA synthetase (aaRS) inhibitor with an IC50 of 2.10 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 91 exhibits antibacterial activities.
  • HY-146265
    Antibacterial agent 92

    Aminoacyl-tRNA Synthetase Bacterial Infection
    Antibacterial agent 92 (Compound 36k) is a triple-site aminoacyl-tRNA synthetase (aaRS) inhibitor with an IC50 of 0.58 μM against Salmonella enterica threonyl-tRNA synthetase (SeThrRS). Antibacterial agent 92 exhibits antibacterial activities.
  • HY-N10282
    Isodihydroauroglaucin

    Fungal Bacterial Endogenous Metabolite Infection
    Isodihydroauroglaucin, a fungal metabolite, shows antibacterial activity.
  • HY-N3353
    Luteone

    Bacterial Fungal Infection
    Luteone is a natural isoflavone, with antioxidant, antibacterial and antifung activities.
  • HY-146098
    Antibacterial agent 105

    Bacterial Antibiotic Infection
    Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC90=2.64 μM)。Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC90s of 11.18, 11.18,0.70,1.40,44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum,BCG, E. aerogenes and S. aureus, respectively.
  • HY-146059
    Antibacterial agent 99

    Bacterial Infection
    Antibacterial agent 99 (compound 7b) is a potent antibacterial agent. Antibacterial agent 99 shows significant antibacterial and antifungal activity. Antibacterial agent 99 dose not show haemolytic activity.
  • HY-112240
    Antibacterial agent 104

    Bacterial Antibiotic Infection
    Antibacterial agent 104 (Compound 7) is a potent antibacterial agent. Antibacterial agent 104 displays excellent antibacterial activity in vitro and good efficacy in vivo against MRSA.
  • HY-146263
    ThrRS-IN-3

    Others Infection
    ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities.
  • HY-146060
    Antibacterial agent 100

    Bacterial Fungal Infection
    Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans, respectively.
  • HY-131554
    Tibezonium iodide

    Bacterial Antibiotic Infection
    Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections.
  • HY-N7252
    Daphnin

    Bacterial Infection
    Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever.
  • HY-14762
    Besifloxacin

    Antibiotic Bacterial Infection
    Besifloxacin is a fluoroquinolone antimicrobial agent. Besifloxacin can inhibit cytokine production by monocytes. Besifloxacin has broad-spectrum antibacterial activity.
  • HY-N9488
    Girinimbine

    Girinimbin

    Apoptosis Bacterial Parasite Cancer Infection Inflammation/Immunology
    Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.
  • HY-N7057
    Nonanoic acid

    Pelargonic acid

    Bacterial Infection
    Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
  • HY-N0565
    Doxycycline

    MMP Bacterial Antibiotic Cancer Infection
    Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity.
  • HY-N0565A
    Doxycycline hydrochloride

    MMP Bacterial Antibiotic Cancer Infection
    Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity.
  • HY-144121
    Ph-Ph+

    Bacterial Fungal Apoptosis Cancer Infection
    Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities.
  • HY-N0565B
    Doxycycline (hyclate)

    Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

    Antibiotic MMP Bacterial Cancer Infection
    Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity.
  • HY-N0565C
    Doxycycline calcium

    MMP Bacterial Antibiotic Cancer Infection
    Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity.
  • HY-143236
    DHFR-IN-1

    Bacterial Fungal Infection
    DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249.
  • HY-N10227
    Geodin

    PAI-1 Antibiotic Infection Inflammation/Immunology
    Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1).
  • HY-N1654
    2',3'-Dehydrosalannol

    Bacterial Infection
    2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively.
  • HY-N10259
    Norfunalenone

    Bacterial Cancer Infection
    Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM).
  • HY-17395
    Terbinafine hydrochloride

    TDT 067 hydrochloride

    Fungal Bacterial Antibiotic Infection
    Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-17395A
    Terbinafine

    TDT 067

    Fungal Bacterial Antibiotic Infection
    Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-P2569
    Malformin A1

    Apoptosis Cancer
    Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9.
  • HY-147988
    DNA Gyrase-IN-5

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains.
  • HY-17395B
    Terbinafine lactate

    TDT 067 lactate

    Antibiotic Fungal Bacterial Infection
    Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-131907
    LpxC-IN-5

    Bacterial Infection
    LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively.
  • HY-147948
    DNA Gyrase-IN-4

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively.
  • HY-105084
    Lubeluzole

    Others Neurological Disease
    Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity.
  • HY-N8971
    Bauer-7-ene-3β,16α-diol

    16α-Hydroxybauerenol

    Bacterial Infection
    Bauer-7-ene-3β,16α-diol, a triterpenoid, is a natural product that can be isolated from dried flower buds of Tussilago farfara L. or Petasites tricholobus (Compositae). Bauer-7-ene-3β,16α-diol shows medium antibacterial activity against E. coli.
  • HY-143415
    Metallo-β-lactamase-IN-7

    Bacterial Infection
    Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains.
  • HY-N0540
    Cynaroside

    Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside

    Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal Cancer Infection
    Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities.
  • HY-143414
    Metallo-β-lactamase-IN-6

    Bacterial Infection
    Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL.
  • HY-N10296
    Curvulamine A

    Bacterial Infection
    Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity.
  • HY-143643
    Antibacterial agent 72

    Bacterial Infection
    Antibacterial agent 72 displays the antibacterial activities by targeting the bacterial membrane.
  • HY-147546
    Antibacterial agent 107

    Bacterial Infection
    Antibacterial agent 107 (compound 14) is a potent antibacterial agent. Antibacterial agent 107 shows potent antibacterial activity against Gram-positive bacteria, with a MIC of 1.56 μg/mL (MRSA). Antibacterial agent 107 exhibits low hemolytic activity, high membrane selectivity, and rapid bactericidal activity. Antibacterial agent 107 shows effective in vivo efficacy in the murine model of bacterial keratitis caused by Staphylococcus aureus ATCC29213.
  • HY-146403
    Antibacterial agent 98

    Bacterial Infection
    Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus).
  • HY-139739
    Antibacterial agent 31

    Bacterial Infection
    Antibacterial agent 31 shows the antibacterial activity against rice bacterial leaf streak.
  • HY-U00225
    A7132

    Bacterial Infection
    A7132 is an antibacterial agent. A7132 possess broad and potent antibacterial activity.
  • HY-101819
    Antibacterial compound 1

    Bacterial Infection
    Antibacterial compound 1 is a oxazolidinone extracted from patent WO1999037630A1 with antibacterial activities.
  • HY-19147
    BMY-43748

    Bacterial Infection
    BMY-43748 is a promising antibacterial agent, exhibiting great in vitro and in vivo antibacterial activity.
  • HY-146047
    Antibacterial agent 94

    Bacterial Infection
    Antibacterial agent 94 (compound 5b) is a potent antibacterial agent. Antibacterial agent 94 show antibacterial activities and show the capability of eradicating MRSA persisters. Antibacterial agent 94 has an effect on bacterial membrane. Antibacterial agent 94 interferes in phosphatidylglycerol (PG) synthesis pathway.
  • HY-146722
    Antibacterial agent 89

    Bacterial DNA/RNA Synthesis Infection
    Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription.
  • HY-P1063
    LF11

    Bacterial Antibiotic Infection
    LF11 is a peptide with antibacterial activity.
  • HY-P1751
    Ceratotoxin B

    Bacterial Infection
    Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .
  • HY-146400
    Antibacterial agent 97

    Bacterial Infection
    Antibacterial agent 97 (hit compound) is a potent antibacterial agent. Antibacterial agent 97 shows antibacterial activities with MIC of 16 and 16 µg/mL for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively.
  • HY-133056
    Pseudomonic acid C

    Antibiotic Bacterial Infection
    Pseudomonic acid C, an antibiotic, possesses antibacterial activity.
  • HY-P1063A
    LF11 TFA

    Bacterial Antibiotic Infection
    LF11 TFA is a peptide with antibacterial activity.
  • HY-105932
    Lexithromycin

    Erythromycin A 9-methoxime; Wy 48314

    Bacterial Antibiotic Infection
    Lexithromycin is an erythromycin A derivative, with antibacterial activity.
  • HY-N6711A
    epi-Equisetin

    Bacterial Infection
    epi-Equisetin, a secondary metabolite, has antibacterial activity.
  • HY-146266
    Antibacterial agent 93

    Aminoacyl-tRNA Synthetase Bacterial Infection
    Antibacterial agent 93 (compound 36l) is a potent aminoacyl-tRNA synthetases (aaRS) inhibitor. Antibacterial agent 93 shows antibacterial activities against some gram-positive and -negative bacteria.
  • HY-126629
    Antibacterial agent 12

    Bacterial Infection
    Antibacterial agent 12, a biaryloxazolidinone analogue, is an antibacterial agent against antibiotic-susceptible and antibiotic-resistant Gram-positive bacteria.
  • HY-U00120
    Picloxydine

    Bacterial Infection
    Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.
  • HY-N2061
    Lindenenol

    Bacterial Infection
    Lindenenol is isolated from Radix linderae, with antioxidant and antibacterial activities.
  • HY-N8206
    Chrysophanol tetraglucoside

    Bacterial Metabolic Disease Inflammation/Immunology
    Chrysophanol tetraglucoside possesses anti-hypolipidemic and antibacterial activities.
  • HY-B0210
    Cefoperazone

    Bacterial Antibiotic Infection
    Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
  • HY-146470
    Antibacterial agent 103

    Bacterial Infection
    Antibacterial agent 103 (compound 7) has highly antibacterial activity against kinds of Gram-positive and -negative bacteria. Antibacterial agent 103 can be used for researching inhibition of resistance bacterial strains.
  • HY-146374
    Antibacterial agent 96

    Bacterial Infection
    Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against drug-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells.
  • HY-142545
    Antibacterial agent 68

    Bacterial Infection
    Antibacterial agent 68 (compound 4d) is an antibacterial agent against drug-resistant Escherichia coli. Antibacterial agent 68 has low cytotoxicity and exerts strong antibacterial activities against multidrug-resistant Escherichia coli at low concentrations as 0.007 mM.
  • HY-16672
    AVX 13616

    Bacterial Infection
    AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens.
  • HY-B0210C
    Cefoperazone dihydrate

    Bacterial Antibiotic Infection Inflammation/Immunology
    Cefoperazone dihydrate, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
  • HY-122930
    Lysicamine

    Bacterial Cancer Infection Inflammation/Immunology
    Lysicamine, a natural compound, possesses antibacterial, anticancer and anti-inflammation activity.
  • HY-N0129
    Sclareolide

    Bacterial Infection
    Sclareolide is isolated from the flower of Salvia sclarea with antibacterial and cytotoxic activities.
  • HY-147958
    Antibacterial agent 113

    Bacterial Infection
    Antibacterial agent 113 (compound 3) is a potent antibacterial agent. Antibacterial agent 113 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values all of 15625 μM.
  • HY-147531
    Antibacterial agent 106

    Bacterial Infection
    Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-drug resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages.
  • HY-130839
    LolCDE-IN-1

    Bacterial Infection
    LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity.
  • HY-N3056
    Pinosylvin monomethyl ether

    Bacterial Fungal Infection
    Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity.
  • HY-N1944
    Nerolidol

    Bacterial Fungal Parasite Endogenous Metabolite Cancer Infection
    Nerolidol is a natural membrane-active sesquiterpene, with antitumor, antibacterial, antifungal and antiparasitic activity.
  • HY-139597
    Temocillin disodium

    BRL 17421 disodium

    Bacterial Infection Inflammation/Immunology
    Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity.
  • HY-N7609
    Kipukasin D

    Bacterial Infection
    Kipukasin D is an natural nucleoside derived from Aspergillus versicolor with antibacterial activity.
  • HY-N4052
    Heraclenol

    Bacterial Infection
    Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities.
  • HY-N5008
    Macranthoside B

    Bacterial Infection
    Macranthoside B, isolated from Flos Lonicerae, possesses anti-bacterial activity.
  • HY-B1915
    Micronomicin

    Gentamicin C2b; Antibiotic XK-62-2; Sagamicin

    Bacterial Infection
    Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities.
  • HY-138621
    Antibacterial agent 19

    Bacterial Infection
    Antibacterial agent 19 (compound 8) is a potent antibacterial agent. Antibacterial agent 19 has antibacterial activity against K. pneumoniae, (M-R)S. aureus and (M-R,V-R)S. aureus with MIC values of 0.022, 0.022 and 0.045 mg/mL, respectively.
  • HY-143232
    Antibacterial agent 73

    Fungal Bacterial Cancer Infection
    Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM.
  • HY-U00389
    WQ3810

    KPI-10 free base

    Bacterial Infection
    WQ3810 is an orally active fluoroquinolone, with potent antibacterial activities.
  • HY-147866
    Antibacterial agent 110

    Bacterial DNA/RNA Synthesis ROS Kinase Infection
    Antibacterial agent 110 (Compound 4e) is a potent antibacterial agent with a MIC value of 1 μg/mL against P. aeruginosa. Antibacterial agent 110 possesses favorable antibiofilm activity and can destroy cell membranes. Antibacterial agent 110 causes metabolic arrest and intracellular oxidative stress, and obstructs DNA replication.
  • HY-121620
    Monolaurin

    1-Monolaurin

    Bacterial SARS-CoV Infection Inflammation/Immunology
    Monolaurin (1-Monolaurin) possesses anti-viral and anti-bacterial activity.
  • HY-128467
    Dehydroacetic acid sodium

    Sodium dehydroacetate

    Bacterial Fungal Infection
    Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
  • HY-B0210A
    Cefoperazone sodium salt

    CP 52640-2

    Bacterial Antibiotic Infection
    Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
  • HY-N7996
    Matairesinoside

    Bacterial Fungal Infection
    Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity.
  • HY-147959
    Antibacterial agent 114

    Bacterial Infection
    Antibacterial agent 114 (compound 1) is a potent antibacterial agent. Antibacterial agent 114 shows antibacterial activity against P.aeruginosa, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, S.mutans, and S.aureus microorganisms, with MIC values of 625, 625, 625, 625, 625, 1250 and 1250 μM, respectively.
  • HY-147957
    Antibacterial agent 112

    Bacterial Infection
    Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively.
  • HY-N0080
    Ulopterol

    Peucedanol methyl ether

    Bacterial Fungal Infection
    Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities.
  • HY-132925
    Antifungal agent 16

    Fungal Infection
    Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
  • HY-W017241
    1-Naphthalenemethanol

    1-Hydroxymethylnaphthalene

    Bacterial Infection Inflammation/Immunology
    1-Naphthalenemethanol is a natural compound the root bark extracts of Annona senegalensis with antibacterial activity.
  • HY-P1062
    Lauryl-LF 11

    Bacterial Antibiotic Infection
    Lauryl-LF 11, N-terminally acylated analogue of LF11, is a peptide with antibacterial activity.
  • HY-19081
    KB-5246

    Bacterial Infection
    KB-5246 is a tetracyclic quinolone and displays antibacterial activities.
  • HY-N3798
    Effusanin A

    Bacterial Infection
    Effusanin A is a natural product that can be found in Isodon rugosus. Effusanin A exhibits DNA-damaging and antibacterial activities.
  • HY-B1297
    Ceforanide

    Bacterial Antibiotic Infection
    Ceforanide is a second generation cephalosporin administered intravenously or intramuscularly. Ceforanide has a spectrum of in vitro antibacterial activity.
  • HY-B0330D
    (R)-Ofloxacin

    Dextrofloxacin

    Bacterial Infection
    (R)-Ofloxacin (Dextrofloxacin) is an antibiotic useful for the treatment of a number of bacterial infections. Antibacterial activity.
  • HY-101411
    4-Acetamidobutanoic acid

    N-acetyl GABA

    GABA Receptor Endogenous Metabolite Bacterial Others
    4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities.
  • HY-P1062A
    Lauryl-LF 11 TFA

    Bacterial Antibiotic Infection
    Lauryl-LF 11 TFA, N-terminally acylated analogue of LF11, is a peptide with antibacterial activity.
  • HY-N6050
    Lycorenine

    Bacterial Cancer Infection Cardiovascular Disease
    Lycorenine is an alkaloid that has vasodepressor action. Lycorenine also exhibits anticancer and antibacterial activities.
  • HY-N3031
    Grosvenorine

    Bacterial Infection
    Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii. Grosvenorine exhibits good antibacterial and antioxidant activities.
  • HY-N10211
    Saccharothrixin K

    Bacterial Endogenous Metabolite Infection
    Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL.
  • HY-129806
    Rugulosin

    (+)-Rugulosin

    Bacterial Fungal Infection
    Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity.
  • HY-120315
    Nyssoside

    Bacterial Infection
    Nyssoside, a ellagic acid derivative, has significant antioxidant activity and shows antibacterial activity against different pathogenic bacteria.
  • HY-N6248
    Cowaxanthone B

    Bacterial Infection
    Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity.
  • HY-N8091
    Lehmannine

    Bacterial Cancer Infection
    Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities.
  • HY-B1211
    Dehydroacetic acid

    Biocide 470F

    Bacterial Fungal Infection
    Dehydroacetic acid (Biocide 470F), a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity.
  • HY-B0453
    Econazole nitrate

    Fungal Bacterial Antibiotic Cancer Infection
    Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.
  • HY-W007771
    Acridone

    Bacterial Cancer Infection
    Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities.
  • HY-B0308
    Sparfloxacin

    CI-978; AT-4140

    Bacterial Antibiotic Infection
    Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.
  • HY-N7985
    Pendulone

    Parasite Bacterial Cancer Infection
    Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity.
  • HY-146458
    Antibacterial agent 102

    Bacterial Cytochrome P450 Infection
    Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice.
  • HY-B0210S
    Cefoperazone-d5

    Bacterial Antibiotic Infection
    Cefoperazone-d5 is deuterium labeled Cefoperazone. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity.
  • HY-N2604
    Loureirin C

    Others Cancer Infection Metabolic Disease Inflammation/Immunology Neurological Disease
    Loureirin C has anti-bacterial, anti-spasmodic, anti-inflammatory, analgesic, anti-diabetic, and anti-tumor activities.
  • HY-77995
    2-Methoxybenzaldehyde

    o-Anisaldehyde

    Bacterial Fungal Infection
    2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity.
  • HY-N0644
    Carnosic acid

    Apoptosis Bacterial Cancer Inflammation/Immunology
    Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.
  • HY-N5009
    Thermopsine

    Bacterial Infection
    Thermopsine is a quinolizidine alkaloid isolated from the fruits and pods and stem bark of Sophora velutina subsp. Thermopsine has antibacterial activity.
  • HY-N0415
    Trigonelline chloride

    Trigonelline hydrochloride

    HSV Bacterial Fungal Cancer Infection Metabolic Disease
    Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
  • HY-N5002
    (+)-Viroallosecurinine

    Bacterial Infection
    (+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus. Antibacterial activity.
  • HY-139887
    Antibacterial agent 63

    Bacterial Infection
    Antibacterial agent 63, a conjugate of aztreonam to a siderophore mimetic, shows activity against gram-negative bacteria.
  • HY-N10474
    Obtusalin

    Bacterial Others
    Obtusalin is a triterpenoid found in R. dauricum for the first time and shows UV absorption at 210 nm. Obtusalin has some antibacterial activity.
  • HY-N0337
    Eugenol

    Bacterial Parasite Reactive Oxygen Species Apoptosis Ferroptosis Infection Inflammation/Immunology Cancer
    Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.
  • HY-10882
    Clotrimazole

    Fungal Bacterial Autophagy Antibiotic Infection Cancer
    Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
  • HY-132918
    Antibacterial agent 30

    Bacterial Infection
    Antibacterial agent 30 demonstrates excellent in vitro activity against Xoo with EC50 value of 1.9 μg/mL.
  • HY-W072009
    5,7-Dihydroxycoumarin

    Bacterial Infection
    5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities.
  • HY-N2192
    Swertianolin

    Cholinesterase (ChE) HBV Bacterial Infection Inflammation/Immunology
    Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity.
  • HY-W049970
    Carvacrol methyl ether

    Bacterial Infection
    Carvacrol methyl ether, a Carvacrol analog, can be isolated from plant volatile oil. Carvacrol methyl ether exhibits antibacterial activity.
  • HY-136150
    Methyl carnosate

    Bacterial Infection
    Methyl camosate is a diterpene isolated from Salvia officinalis or Rosmarinus officinalis. Methyl camosate has potent antioxidant and anti-bacterial activity.
  • HY-N2423
    Sinigrin hydrate

    Others Cancer Infection Inflammation/Immunology
    Sinigrin (hydrate) is a natural aliphatic glucosinolate present in plants of the Brassicaceae family. Sinigrin (hydrate) exhibits anti-cancer, antibacterial, antifungal, antioxidant and anti-inflammatory activities.
  • HY-N10391
    (-)-Cleistenolide

    Cleistenolide

    Others Cancer Infection
    (-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity.
  • HY-146591
    Antibacterial agent 87

    Bacterial Infection
    Antibacterial agent 87 (Compound 4h) is a potent antibacterial agent with MIC values of 0.125, 0.0625 and 0.0625 μg/mL against MRSA, MRSE and S. aureus, respectively.
  • HY-147835
    Antibacterial agent 109

    Bacterial Infection
    Antibacterial agent 109 (Compound C-2) is a potent antibacterial agent against both gram-positive and gram negative bacteria, and non-mutagenic. Antibacterial agent 109 inhibits protein synthesis by blocking the extension of new peptide chains.
  • HY-117260
    Coformycin

    Adenosine Deaminase Bacterial Cancer Infection
    Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity.
  • HY-21210
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-

    Bacterial Infection
    6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-, derived from 2,3-Bis(bromomethyl)quinoxaline, shows antibacterial activity.
  • HY-N7321A
    (R)-Eucomol

    Bacterial Cancer Infection
    (R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells.
  • HY-N5125
    2-Hydroxy-1-methoxyanthraquinone

    Bacterial Infection Inflammation/Immunology
    2-Hydroxy-1-methoxyanthraquinone could be isolated from the stem bark of Morinda lucida Benth. (Rubiaceae) and possesses antibacterial activity.
  • HY-B0798
    Cefpiramide sodium

    SM-1652; Wy-44635

    Bacterial Antibiotic Infection
    Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
  • HY-P1581
    Ceratotoxin A

    Bacterial Infection
    Ceratotoxin A, a 29-residue peptide isolated from the accessory gland secretion fluid, with strong anti-bacterial activity.
  • HY-W004296
    1-Heptadecanol

    Bacterial Infection Inflammation/Immunology
    1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves.
  • HY-U00194
    Vebufloxacin

    Flumenique; OPC7241; DM8966

    Bacterial Infection
    Vebufloxacin (Flumenique; OPC7241; DM8966) exhibits potent antibacterial activity against gram-positive and -negative bacteria.
  • HY-W115276
    Fenticonazole

    Bacterial Fungal Infection
    Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis.
  • HY-W035409
    RPW-24

    Bacterial Infection
    RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity.
  • HY-B1275
    Cephalothin sodium

    Cefalotin sodium

    Bacterial Antibiotic Infection
    Cephalothin sodium is a first generation cephem antibiotic with a wide range antibacterial activity, is active against gram-positive and gram-negative bacteria.
  • HY-B1366
    Meclocycline Sulfosalicylate Salt

    Bacterial Antibiotic Infection
    Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris.
  • HY-B0177
    Tinidazole

    Bacterial Infection
    Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa.
  • HY-N10181
    11-Keto fusidic acid

    Simplifusidic acid I

    Others Infection
    11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.
  • HY-139558
    Zapnometinib

    PD0184264; ATR-002

    MEK Influenza Virus Bacterial Cancer Infection
    Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities.
  • HY-N1984
    Artemisic acid

    Qing Hao acid; Artemisinic acid; Arteannuic acid

    Bacterial Cancer Infection Metabolic Disease Inflammation/Immunology
    Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
  • HY-130840
    LolCDE-IN-2

    Bacterial Cancer
    LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity.
  • HY-W004294
    1-Tetradecanol

    Bacterial Infection Inflammation/Immunology
    1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity.
  • HY-13234S
    Rifaximin-d6

    Bacterial Antibiotic Infection
    Rifaximin-d6 is the deuterium labeled Rifaximin. Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity.
  • HY-121054
    Chalcone

    Bacterial Cancer Inflammation/Immunology
    Chalcone is isolated from Glycyrrhizae inflata and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities.
  • HY-B0996
    Hexetidine

    NSC-17764

    Bacterial Fungal Infection
    Hexetidine is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine give important potential for treatment of oral infections.
  • HY-14957
    Ozenoxacin

    T-3912

    Bacterial Infection
    Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.
  • HY-137990
    Questin

    Bacterial Infection
    Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL.
  • HY-B0330DS
    (R)-Ofloxacin-d3

    Bacterial Antibiotic Infection
    (R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin (Dextrofloxacin) is an antibiotic useful for the treatment of a number of bacterial infections. Antibacterial activity.
  • HY-N6656
    6-Hydroxycoumarin

    Others Cancer Inflammation/Immunology
    6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.
  • HY-N7116
    Lawsone methyl ether

    2-​Methoxy-​1,​4-​naphthoquinone

    Fungal Bacterial Infection
    Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.
  • HY-N7449
    Neamine

    Bacterial Cancer Infection Neurological Disease Cardiovascular Disease
    Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities.
  • HY-10882S
    Clotrimazole-d5

    Fungal Bacterial Autophagy Antibiotic Infection Cancer
    Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
  • HY-107805
    Dihydroactinidiolide

    Others Cancer Infection Neurological Disease
    Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. Dihydroactinidiolide has antioxidant activity, antibacterial activity, anticancer activity and neuroprotective effect.
  • HY-16752
    Relebactam

    MK-7655

    Bacterial Infection
    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.
  • HY-N7111
    Sultamicillin tosylate

    Bacterial Infection
    Sultamicillin (tosylate) is a potent and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity. Sultamicillin (tosylate) is the tosylate salt of the double ester of sulbactam plus ampicillin.
  • HY-147805
    SARS-CoV-2 3CLpro-IN-4

    SARS-CoV Bacterial Fungal Infection
    SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
  • HY-147804
    SARS-CoV-2 3CLpro-IN-3

    SARS-CoV Bacterial Fungal Infection
    SARS-CoV-2 3CLpro-IN-3 (Compound 3d) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
  • HY-N10402
    Norbatzelladine L

    Fungal Bacterial Parasite Cancer Infection
    Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC50 of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities.
  • HY-123319A
    Antofloxacin

    Bacterial Infection
    Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species.
  • HY-123319
    Antofloxacin hydrochloride

    Bacterial Infection
    Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the treatment of infections caused by a diverse group of bacterial species.
  • HY-B1085
    Cinoxacin

    Compound 64716

    Bacterial Antibiotic DNA/RNA Synthesis Infection
    Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis.
  • HY-N7504
    Isopsoralenoside

    Bacterial Cancer Infection Metabolic Disease
    Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
  • HY-B1336
    Furazolidone

    Bacterial Apoptosis Antibiotic Infection
    Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.
  • HY-N7089
    Benzoyleneurea

    Bacterial Infection
    Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors.
  • HY-N7097
    Sulbenicillin disodium

    Bacterial Antibiotic Infection
    Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic with antibacterial activity against a number of mucoid and non-mucoid strains of Pseudomonas aeruginosa.
  • HY-Y0055
    Phenothiazine

    Antibiotic Fungal Bacterial Infection Neurological Disease
    Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
  • HY-N0199
    Albaspidin AA

    Bacterial Infection
    Albaspidin AA displays strong antibacterial activity against the vegetative form of Paenibacillus larvae (P. larvae) (MIC=220 μM).
  • HY-133619
    8-Abietenic acid

    Fungal Infection
    8-Abietenic acid is the secondary metabolite of mucorinic acid and is isolated from a solid culture of the fungus Mucor spp. isolated on insect Acalymma bivittula. 8-Abietenic acid exhibits antibacterial and insecticidal activities.
  • HY-123026
    Salannin

    Bacterial Infection
    Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria.
  • HY-143408
    OYYF-175

    Bacterial Infection
    OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-
  • HY-147856
    Antileishmanial agent-11

    Parasite Infection
    Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively.
  • HY-147857
    Antileishmanial agent-12

    Parasite Infection
    Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 14.9, 21.3 and 9.3 μM, respectively.
  • HY-115349
    Neamine tetrahydrochloride

    Bacterial Cancer Infection Neurological Disease
    Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.
  • HY-107330
    (6R,7S)-Cefminox sodium heptahydrate

    Antibiotic Others
    (6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity.
  • HY-P1539A
    Cecropin A TFA

    Bacterial Antibiotic Cancer Infection Inflammation/Immunology
    Cecropin A TFA is a linear 37-residue antimicrobial polypeptide isolated from Hyalaphora cecropia pupae. Cecropin A TFA exhibits anti-bacterial, anti-inflammatory and anti-cancer activity.
  • HY-117319
    Indolmycin

    TAK-083; PA-155A

    Antibiotic Bacterial Infection Inflammation/Immunology
    Indolmycin (TAK-083), an antibiotic, is a competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase (TrpS). Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity.
  • HY-N4102
    5,7-Dihydroxy-4-methylcoumarin

    Fungal Bacterial Infection
    5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
  • HY-30235A
    Benzydamine hydrochloride

    PGE synthase Bacterial Inflammation/Immunology
    Benzydamine hydrochloride is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity.
  • HY-139863
    Antibacterial agent 62

    Bacterial Infection
    Antibacterial agent 62 is a novel redox cycling antituberculosis chemotype with potent bactericidal activity against growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria.
  • HY-135389
    Desmethyl Levofloxacin

    Drug Metabolite Infection
    Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
  • HY-124923
    Lupulone

    Bacterial Cancer Infection
    Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties.
  • HY-N6078
    Thalrugosaminine

    Bacterial Infection
    Thalrugosaminine is a benzylisoquinoline alkaloid isolated from the roots of Thalictrum minus. Thalrugosaminine shows good antibacterial activity with MIC values of 64-128 µg/ml.
  • HY-N10401
    Batzelladine D

    Fungal Bacterial Parasite Cancer Infection
    Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC50 of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities.
  • HY-N7476
    Colominic acid sodium salt

    Polysialic acid sodium salt

    Antibiotic Infection Inflammation/Immunology
    Colominic acid sodium salt (Polysialic acid sodium salt) could be naturally isolated from the cell wall of Escherichia coli and animals, gives a red color which has an absorption maximum at 530 nm. Colominic acid sodium salt (Polysialic acid sodium salt) possesses anti-bacterial activity.
  • HY-N2357
    Eudesmin

    (-)-Eudesmin; Eudesmine; (-)-Eudesmine

    Ribosomal S6 Kinase (RSK) Cancer Infection Metabolic Disease Inflammation/Immunology
    Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities.
  • HY-N4116
    Xanthyletin

    Fungal Cancer Infection
    Xanthyletin is a coumarin isolated from Citrus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants.
  • HY-B2234
    Povidone iodine

    iodopovidone

    Bacterial Infection
    Povidone iodine (iodopovidone) displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively.
  • HY-B0356AS
    Ciprofloxacin-d8 hydrochloride hydrate

    Bay-09867-d8 hydrochloride hydrate

    Bacterial Antibiotic Infection
    Ciprofloxacin-d8 (Bay-09867-d8) hydrochloride monohydrate is the deuterium labeled Ciprofloxacin hydrochloride monohydrate. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-109754
    Sulopenem etzadroxil

    PF-03709270

    Bacterial Antibiotic Infection
    Sulopenem etzadroxil (PF-03709270) is an orally available ester prodrug form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.
  • HY-P1350
    H-Lys-Trp-Lys-OH

    Bacterial Infection
    H-Lys-Trp-Lys-OH is a small molecule peptide which displays antibacterial and antiviral activities extracted from patent CN 104072579 A, Compound AMP12.
  • HY-132923
    NBTIs-IN-4

    Bacterial Infection
    NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance.
  • HY-B0356BS
    Ciprofloxacin-d8 hydrochloride monohydrate

    Bay-09867-d8 hydrochloride monohydrate

    Bacterial Antibiotic Infection
    Ciprofloxacin-d8 (Bay-09867-d8) hydrochloride monohydrate is the deuterium labeled Ciprofloxacin (hydrochloride monohydrate). Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-125685
    Germacrene D

    Bacterial Fungal Cancer
    Germacrene D is isolated from Bursera species. Germacrene D has antibacterial and antifungal activities and can be used as an adjuvant agent in the application of aminoglycosides and azoles.
  • HY-N0337S
    Eugenol-d3

    Bacterial Parasite Reactive Oxygen Species Apoptosis Ferroptosis Infection Inflammation/Immunology Cancer
    Eugenol-d3 is the deuterium labeled Eugenol. Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.
  • HY-108402
    Cefodizime

    Bacterial Antibiotic Infection
    Cefodizime is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime has no renal toxic effect, good tolerance and immune regulation activity, and has the potential for severe infections of the respiratory and urinary tracts.
  • HY-126562
    Piperlonguminine

    Bacterial Fungal Cancer Infection Inflammation/Immunology Neurological Disease Cardiovascular Disease
    Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.
  • HY-N2387
    Pinosylvin

    Bacterial Apoptosis Autophagy Cancer Infection
    Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus spp, has anti-bacterial activities. Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells.
  • HY-135221
    Cefcapene pivoxil hydrochloride

    Bacterial Antibiotic Infection
    Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity.Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment.
  • HY-147819
    DNA Gyrase-IN-3

    Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-3 (Compound 28) is a bacterial DNA gyrase B inhibitor with IC50s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity.
  • HY-N10267
    Carviolin

    Others Infection
    Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.
  • HY-N0415S
    Trigonelline-d3 chloride

    Trigonelline-d3 hydrochloride

    HSV Bacterial Fungal Cancer Infection Metabolic Disease
    Trigonelline-d3 chloride (Trigonelline-d3 hydrochloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
  • HY-B0330S1
    (S)-Ofloxacin-d3

    Bacterial Antibiotic Infection
    (S)-Ofloxacin-d3 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
  • HY-145326
    Antibacterial agent 67

    Fungal Others
    Antibacterial agent 67 (IC50 = 0.03 μM) has a great enzyme-inhibiting activity increase toward succinate dehydrogenase in comparison with fluxapyroxad (IC50 = 4.40 μM).
  • HY-N9343
    Kulactone

    Bacterial Fungal Parasite Infection Inflammation/Immunology
    Kulactone, a natural bioflavonoid and an inhibitor against jRdRp, possesses antifungal, antibacterial and antiplasmodial activities. Kulactone exhibit no crossing through Blood Brain Barrier (BBB).
  • HY-N8186
    (3R)-7,4’-Dihydrohomoisoflavanone

    Bacterial Infection
    (3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against S. aureus and methicillin-resistant Staphylococcus aureus (MRSA).
  • HY-B0213
    Sulfameter

    Sulfametoxydiazine; 5-Methoxysulfadiazine

    Antibiotic Bacterial Infection
    Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
  • HY-N6310
    Talaromycesone A

    Bacterial Infection
    Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC50 of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC50 of 7.49 μM.
  • HY-108402A
    Cefodizime sodium

    Bacterial Antibiotic Infection
    Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts.
  • HY-100385
    Brevianamide F

    Cyclo(L-Pro-L-Trp)

    PI3K Bacterial Infection
    Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 µM.
  • HY-N6895
    Violanthin

    Cholinesterase (ChE) Inflammation/Immunology
    Violanthin is isolated from the aerial parts of Piper bavinum, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM.
  • HY-N6871
    Abietic acid

    Bacterial Cancer Infection Metabolic Disease Inflammation/Immunology
    Abietic acid, a diterpene isolated from Pimenta racemosa var. grissea, possesses antiproliferative, antibacterial, and anti-obesity properties. Abietic acid inhibits lipoxygenase activity for allergy treatment.
  • HY-10393
    Eperezolid

    PNU-100592

    Bacterial Antibiotic Infection
    Eperezolid(PNU-100592) is a oxazolidinone antibacterial agent, Eperezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).
  • HY-N3241
    Mucrolidin

    Bacterial Infection
    Mucrolidin is an eudesmane-type sesquiterpenoid isolated from aerial parts of homalomena occulta. Mucrolidin exhibits weak antibacterial activities when it compares to Rifampicin (HY-B0272).
  • HY-B1418
    Tazobactam

    CL-298741; YTR-830H

    Antibiotic Bacterial Infection
    Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
  • HY-136306
    Metallo β-lactamase ligand 1

    Bacterial Infection
    Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.
  • HY-B0177S
    Tinidazole-d5

    Bacterial Infection
    Tinidazole-d5 is the deuterium labeled Tinidazole. Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa.
  • HY-N7066
    Difloxacin hydrochloride

    Bacterial Antibiotic Infection
    Difloxacin hydrochloride is a broad-spectrum antibacterial drug. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV.
  • HY-B1444
    Isoconazole nitrate

    Bacterial Fungal Antibiotic Infection
    Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.
  • HY-144300
    Rifasutenizol

    TNP-2198

    Bacterial Infection
    TNP-2198 is a potent and orally bioavailable dual-targeted antibacterial agent. TNP-2198 has potent activity against microaerophilic and anaerobic bacterial pathogens.
  • HY-111588
    Xanthoangelol

    Apoptosis Monoamine Oxidase Bacterial AMPK Cancer Infection Inflammation/Immunology
    Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.
  • HY-N6961
    Lapachol

    Bacterial Fungal Influenza Virus Parasite Cancer Infection Inflammation/Immunology
    Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae). Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities.
  • HY-16137
    Cefaloglycin

    Cephaloglycin

    Bacterial Infection
    Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration.
  • HY-B0212
    Sulfapyridine

    Bacterial Antibiotic Infection Inflammation/Immunology
    Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities.
  • HY-106668
    Isepamicin

    Sch 21420

    Antibiotic Bacterial Infection
    Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance.
  • HY-114816
    N-Butanoyl-L-homoserine lactone

    C4-HSL; N-Butyryl-L-homoserine lactone

    ADC Linkers Bacterial Infection Inflammation/Immunology
    N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
  • HY-146593
    Antibacterial agent 88

    Bacterial Infection
    Antibacterial agent 88 (Compound 5h) is a potent antibacterial agent with MIC values of both ≤0.0156 μg/mL against MRSA, MRSE and S. aureus. Antibacterial agent 88 also inhibits B. subtilis with an MIC of 4 μg/mL.
  • HY-N3074
    Hexahydrofarnesyl acetone

    6,10,14-Trimethyl-2-pentadecanone

    Bacterial Infection Inflammation/Immunology
    Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone), a sesquiterpene isolated from Launaea mucronata, is the major constituents of the essential oil. Hexahydrofarnesyl acetone has antibacterial, anti-nociceptive and anti-inflammation activities.
  • HY-136559
    6-Azathymine

    Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial Influenza Virus Infection
    6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.
  • HY-N10129
    Uvaretin

    Bacterial Infection
    A mixture of uvaretin and isouvaretin (HY-N10130) exhibits significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM).
  • HY-N3907
    Fraxidin

    Bacterial Infection
    Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.
  • HY-B0356S
    Ciprofloxacin-d8 hydrochloride

    Bay-09867-d8 hydrochloride

    Bacterial Antibiotic Infection
    Ciprofloxacin-d8 (Bay-09867-d8) hydrochloride is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-138650
    Monocaprylin

    Glyceryl monocaprylate; Sefsol 318

    Bacterial Inflammation/Immunology
    Monocaprylin (Glyceryl monocaprylate), a monoglyceride of caprylic acid, exhibits an excellent antibacterial activity. Monocaprylin inhibits a variety of foodborne pathogenic and spoilage microorganisms and has the potential for an alternative food preservative research.
  • HY-B0356S1
    Ciprofloxacin-d8

    Bay-09867-d8

    Bacterial Antibiotic Infection
    Ciprofloxacin-d8 (Bay-09867-d8) is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-40354A
    Tofacitinib citrate

    Tasocitinib citrate; CP-690550 citrate

    JAK Apoptosis Bacterial Fungal Influenza Virus Cancer Infection Inflammation/Immunology
    Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
  • HY-N10130
    Isouvaretin

    Bacterial Infection
    A mixture of uvaretin (HY-N10129) and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM).
  • HY-N7516
    4'-Hydroxy-2,4-dimethoxychalcone

    Parasite Bacterial Fungal Infection
    4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity.
  • HY-119917
    Gossypetin

    p38 MAPK MEK Bacterial Cancer Infection
    Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities.
  • HY-N5020
    Carabrone

    Bacterial Infection
    Carabrone is isolated from the fruits of Carpesium abrotanoides , is a well-known sesquiterpene and exhibits significant anti-bacterial and anti-tumor activities. Carabrone exhibits antifungal activities in vitro and in vivo against Botrytis cinerea, Colletotrichum lagenarium(EC50=7.10 μg/mL) and Erysiphe graminis.
  • HY-W018800
    4(3H)-Quinazolinone

    Bacterial Cancer Infection Endocrinology Metabolic Disease Inflammation/Immunology Neurological Disease
    4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities.
  • HY-N0757
    8-​O-​Acetylharpagide

    Bacterial Cancer Infection Inflammation/Immunology
    8-O-Acetylharpagide is an iridoid isolated from Ajuga reptans with antitumoral, antiviral, antibacterial, and anti-inflammatory activities. 8-O-Acetylharpagide also has a biological activity on isolated smooth muscle preparations from guinea pig.
  • HY-N0482
    Phillyrin

    Cytochrome P450 Influenza Virus Bacterial Cancer Infection Inflammation/Immunology
    Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities. Phillyrin has anti-influenza A virus activities.
  • HY-B0330S
    Levofloxacin-d8

    (-)-Ofloxacin-d8

    Bacterial Antibiotic Infection
    Levofloxacin-d8 ((-)-Ofloxacin-d8) is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
  • HY-119502
    Camalexin

    Reactive Oxygen Species Fungal Bacterial Cancer Infection
    Camalexin is a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production.
  • HY-N0126
    Xanthone

    Bacterial Influenza Virus Fungal Apoptosis Cancer Infection Inflammation/Immunology
    Xanthone is isolated from Mangosteen and is known to control cell division and growth, apoptosis, inflammation, and metastasis in different stages of carcinogenesis. Xanthone has anti-oxidant, anti-tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities.
  • HY-N7505
    Norchelerythrine

    Bacterial Infection
    Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL.
  • HY-B0356B
    Ciprofloxacin hydrochloride monohydrate

    Bay-09867 hydrochloride monohydrate

    Bacterial Antibiotic Infection Cancer
    Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-N2208
    4-Hydroxylonchocarpin

    p38 MAPK Cancer Infection Metabolic Disease Inflammation/Immunology
    4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities.
  • HY-B0356
    Ciprofloxacin

    Bay-09867

    Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species Cancer Infection
    Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-N8431
    5-Geranoxy-7-methoxycoumarin

    Bacterial Fungal Cancer Infection
    5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis.
  • HY-N10230
    MC 304

    Phanerosporic Acid

    Others Infection
    MC 304 is a β-resorcylate isolated from cultures of Phanerochaete chrysosporium. MC 304 has antibacterial activity. MC 304 shows a stimulatory effect on root elongation of Lepidium satiuum.
  • HY-Y0055S
    Phenothiazine-d8

    Antibiotic Fungal Bacterial Infection Neurological Disease
    Phenothiazine-d8 is the deuterium labeled Phenothiazine. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
  • HY-N2896
    Arjunolic acid

    Reactive Oxygen Species Inflammation/Immunology
    Arjunolic acid is a saponin isolated from Symplocos lancifolia and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species.
  • HY-106338
    Polyketomycin

    Bacterial ADC Cytotoxin Parasite Cancer Infection
    Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.
  • HY-W013699
    Chlorhexidine diacetate

    Bacterial Antibiotic Infection
    Chlorhexidine diacetate is a biguanide disinfectant with rapid bactericidal activity against both Gram-positive and Gram-negative organism. The antibacterial effect of chlorhexidine diacetate is related to its action on the bacterial cell membrane and to precipitation of intracellular contents.
  • HY-N4167
    3-O-Methylgalangin

    Galangin 3-methyl ether; 3-Methylgalangin

    Bacterial Infection
    3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase.
  • HY-129434A
    4aα,7α,7aα-Nepetalactone

    Bacterial Infection
    4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.
  • HY-B0771
    Cefozopran

    SCE-2787

    Bacterial Antibiotic Infection
    Cefozopran (SCE-2787) is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms.
  • HY-105033
    Irloxacin

    Pirfloxacin

    Bacterial Infection
    Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active.
  • HY-N0055
    Chlorogenic acid

    3-O-Caffeoylquinic acid; Heriguard; NSC-407296

    HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Bacterial Influenza Virus Endogenous Metabolite Cancer Infection Inflammation/Immunology
    Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
  • HY-B0771A
    Cefozopran hydrochloride

    SCE-2787 hydrochloride

    Bacterial Antibiotic Infection
    Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms.
  • HY-N2575
    Hypocrellin A

    PKC Bacterial Parasite Cancer Infection
    Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for anticancer photodynamic therapy (PDT).
  • HY-N0393
    Glabridin

    PPAR Reactive Oxygen Species Bacterial Cancer Infection Inflammation/Immunology
    Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
  • HY-145379
    Miaosporone A

    Parasite Endogenous Metabolite Infection
    Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
  • HY-147818
    DNA Gyrase-IN-2

    Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC50s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity.
  • HY-135652
    Hexyl gallate

    Hexyl 3,4,5-trihydroxybenzoate

    Bacterial Parasite Infection
    Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR. Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM.
  • HY-145325
    Antibacterial agent 66

    Bacterial Infection
    Antibacterial agent 66 (Compound 6q), a trifluoromethylpyridine 1,3,4-oxadiazole derivative, shows activity against Xanthomonas oryzae pv. oryzae (Xoo) with an EC50 value of 7.2 μg/mL.
  • HY-N0250
    Saikosaponin D

    STAT NF-κB Estrogen Receptor/ERR Bacterial Cancer Infection Inflammation/Immunology
    Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
  • HY-N3199
    Neorauflavene

    Bacterial Infection
    Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer.
  • HY-W018025
    5,6-Dihydroxyindole

    Bacterial Fungal Parasite Endogenous Metabolite Infection Inflammation/Immunology
    5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens.
  • HY-N1637
    1-Methyl-2-pentyl-4(1H)-quinolinone

    Others Cancer Infection
    1-Methyl-2-pentyl-4(1H)-quinolinone, a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa, possesses antibacterial and cytotoxic activities for cancer cells.
  • HY-N7503
    Psoralenoside

    Histamine Receptor CaMK Calcium Channel Cancer Infection Metabolic Disease
    Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
  • HY-N2329
    Piperlongumine

    Piplartine

    ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis Cancer Infection Cardiovascular Disease
    Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.
  • HY-B0356A
    Ciprofloxacin monohydrochloride

    Bay-09867 monohydrochloride

    Topoisomerase Apoptosis Mitochondrial Metabolism Reactive Oxygen Species Antibiotic Bacterial Infection Cancer
    Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
  • HY-B2144A
    Chitosan (MW 150000)

    Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)

    Bacterial Fungal Cancer Infection
    Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities.
  • HY-B2144B
    Chitosan (MW 30000)

    Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000)

    Bacterial Fungal Cancer Infection
    Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities.
  • HY-135389S
    Desmethyl Levofloxacin-d8 hydrochloride

    Drug Metabolite Antibiotic Infection
    Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
  • HY-B1190A
    Cefadroxil hydrate

    BL-S 578 hydrate

    Bacterial Antibiotic Infection
    Cefadroxil hydrate (BL-S 578 hydrate) is an orally active and first-generation cephalosporin with a broad spectrum antibacterial activity. Cefadroxil hydrate (BL-S 578 hydrate) also acts as a substrate of the peptide transporter PEPT1 and PEPT2.
  • HY-N10280
    Asperglaucin A

    Bacterial Endogenous Metabolite Infection
    Asperglaucin A represents an unusual phthalide-like derivative. Asperglaucin A exhibits potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM.
  • HY-B1825
    Cefoxitin

    Antibiotic Bacterial Infection
    Cefoxitin, a β-lactam antibiotic, is a broad-spectrum, second-generation cephalosporin. Cefoxitin has a broad spectrum antibacterial activity which includes anaerobic as well as Gram-positive and Gram-negative aerobic bacteria.
  • HY-135389S1
    Desmethyl Levofloxacin-d8

    Drug Metabolite Antibiotic Infection
    Desmethyl Levofloxacin-d8 is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
  • HY-N3307
    (+)-Medioresinol

    Bacterial Fungal Reactive Oxygen Species Apoptosis Infection Neurological Disease Cardiovascular Disease
    (+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk.
  • HY-114816S
    N-butyryl-L-Homoserine lactone-d5

    ADC Linkers Bacterial Infection Inflammation/Immunology
    N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
  • HY-109785A
    (R)-Gyramide A hydrochloride

    Infection
    (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.
  • HY-139010
    Merafloxacin

    CI-934

    SARS-CoV Infection
    Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria.
  • HY-W014612
    Eugenol acetate

    Eugenyl acetate

    Bacterial Fungal Infection
    Eugenol acetate (Eugenyl acetate), a major phytochemical constituent of the essential oil exhibits antibacterial, antioxidant, and anti-virulence activities. Eugenol acetate (Eugenyl acetate), a phytochemical in clove essential oil, against clinical isolates of Candida albicans, Candida parapsilosis, Candida tropicalis, and Candida glabrata.
  • HY-N8406
    Monomethylsulochrin

    Bacterial Antibiotic Infection
    Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL.
  • HY-146023
    Antifungal agent 27

    Bacterial Fungal Infection
    Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively.
  • HY-W024297
    VP-4509

    Bacterial Infection
    VP-4509, an anti-methicillin‐resistant Staphylococcus aureus (MRSA) agent, with the MIC of 49.3 µM. VP-4509 also possesses high antibacterial activity towards gram-negative bacteria P. aeruginosa.
  • HY-N0295
    Protocatechualdehyde

    Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV

    Reactive Oxygen Species Bacterial Cancer Infection
    Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.
  • HY-P2457
    rCRAMP (rat)

    Bacterial Infection Inflammation/Immunology
    rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS.
  • HY-123087
    N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone

    N-(3-oxodecanoyl)-homoserine lactone

    Bacterial Infection
    N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone (N-(3-oxodecanoyl)-homoserine lactone) is a member of N-Acyl homoserine lactone (AHL) from V. alginolyticus strains. N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is used for biofilm formation and has antibacterial activity.
  • HY-N7430
    3-O-Methylellagic acid

    Bacterial Infection Inflammation/Immunology
    3-O-Methylellagic acid is a nature product that can be isolated from Myrciaria cauliflora, with anti-inflammatory activity. 3-O-Methylellagic acid shows an inhibitory effect on glucose transport assay. 3-O-Methylellagic acid has antibacterial activity, with a MIC of 32 μg/mL for Staph. Aureus ATCC 25923.
  • HY-Y1771
    2-Carboxybenzaldehyde

    Others Cancer Infection
    2-Carboxybenzaldehyde is a chemical compound. 2-Carboxybenzaldehyde consists of a benzene ring, with an aldehyde and a carboxylic acid as substituents that are ortho to each other. 2-Carboxybenzaldehyde can be used to form ligands with metal ions. Ni(II) and Cu(II) complexes of 2-Carboxybenzaldehyde thiosemicarbazone has anticancer and antibacterial activities.
  • HY-B0295
    Chloroxine

    Bacterial Antibiotic Infection
    Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp.
  • HY-N6294
    Monocerin

    Bacterial Fungal Infection
    Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca.
  • HY-B0159
    Balofloxacin

    Q-35

    Bacterial Antibiotic Infection
    Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections.
  • HY-N2512
    1-Monomyristin

    FAAH Bacterial Fungal Endogenous Metabolite Autophagy Infection
    1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans.
  • HY-14865B
    Omadacycline tosylate

    PTK 0796 tosylate; Amadacycline tosylate

    Bacterial Antibiotic Infection
    Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
  • HY-14865C
    Omadacycline hydrochloride

    PTK0796 hydrochloride; Amadacycline hydrochloride

    Bacterial Antibiotic Infection
    Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
  • HY-14865
    Omadacycline

    PTK 0796; Amadacycline

    Bacterial Antibiotic Infection
    Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
  • HY-14865A
    Omadacycline mesylate

    PTK 0796 mesylate; Amadacycline mesylate

    Bacterial Antibiotic Infection
    Omadacycline (PTK 0796) mesylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline mesylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline mesylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline mesylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
  • HY-113764
    N-Butanoyl-DL-homoserine lactone

    (Rac)-C4-HSL

    Bacterial Infection Inflammation/Immunology
    N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
  • HY-N6013
    Aloin(mixture of A&B)

    MMP Bacterial Fungal Cancer Infection Inflammation/Immunology
    Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs).
  • HY-B0395
    Sitafloxacin

    DU6859a

    Bacterial Antibiotic Infection
    Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection.
  • HY-B0395B
    Sitafloxacin monohydrate

    DU6859a monohydrate

    Bacterial Antibiotic Infection
    Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection.
  • HY-N7010
    (-)-Corynoxidine

    Cholinesterase (ChE) Bacterial Infection
    (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
  • HY-B0213S1
    Sulfameter-13C6

    Sulfametoxydiazine-13C6; 5-Methoxysulfadiazine-13C6

    Antibiotic Bacterial Infection
    Sulfameter-13C6 is the 13C6 labeled Sulfameter. Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
  • HY-B1831
    Oritavancin

    LY 333328; Orbactiv

    Antibiotic Bacterial Infection Inflammation/Immunology
    Oritavancin (LY 333328) is an orally active glycopeptide antibiotic with activity against gram-positive organisms. Oritavancin shows antibacterial effect against multidrug-resistant S. pneumoniae. Oritavancin inhibits cell wall synthesis and disrupts the membrane potential.
  • HY-147960
    Glycosyltransferase-IN-1

    Bacterial Infection
    Glycosyltransferase-IN-1 (compound 5m) is a potent glycosyltransferase inhibitor, with an IC50 of 82.8 μM. Glycosyltransferase-IN-1 shows antibacterial activity, with MIC values of 6 μg/mL for MSSA, MRSA, B. subtilis and 12 μg/mL for E. coli.
  • HY-40354AS
    Tofacitinib-d3 citrate

    Tasocitinib-d3 citrate; CP-690550-d3 citrate

    JAK Apoptosis Bacterial Fungal Influenza Virus Cancer Infection Inflammation/Immunology
    Tofacitinib-d3 (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
  • HY-N7115
    Sultamicillin

    Bacterial Antibiotic Infection
    Sultamicillin is an orally active double prodrug of Ampicillin/Sulbactan. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with Ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
  • HY-N0530
    Dryocrassin ABBA

    Dryocrassin

    Influenza Virus Bacterial Infection
    Dryocrassin ABBA (Dryocrassin) is an orally active flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Dryocrassin ABBA exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin ABBA inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin ABBA suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.
  • HY-N0941
    beta-Mangostin

    β-Mangostin

    Bacterial Parasite Apoptosis Cancer Infection
    beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).
  • HY-13678
    Meropenem

    SM 7338

    Bacterial Antibiotic Infection
    Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
  • HY-130718
    ThrRS-IN-1

    Bacterial Cancer Infection
    ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities.
  • HY-B0159A
    Balofloxacin dihydrate

    Q-35 dihydrate

    Bacterial Antibiotic Infection
    Balofloxacin dihydrate (Q-35 dihydrate) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin dihydrate can be used for the research of respiratory, intestinal, and urinary tract infections.
  • HY-N6962
    α-Spinasterol

    TRP Channel COX Bacterial Infection Neurological Disease
    α-Spinasterol, isolated from Spinacia oleracea, has antibacterial activity. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.
  • HY-N7652
    Terminolic acid

    Bacterial Infection Inflammation/Immunology
    Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity.
  • HY-128932
    Cefminox sodium

    MT-141

    Bacterial PPAR Prostaglandin Receptor Antibiotic Infection Cardiovascular Disease Endocrinology
    Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension.
  • HY-146503
    Antibacterial agent 86

    Others Infection
    Antibacterial agent 86 (Compound A11) is the most active and displays bacteriostatic activities against methicillin-resistant S. aureus, with MIC values as low as 0.00191 μg/mL, which is 162 and 32 times lower than that of the marketed antibiotics tiamulin and retapamulin, respectively.
  • HY-107329
    Cefathiamidine

    Bacterial Antibiotic Infection
    Cefathiamidine is a first-generation cephalosporin antibacterial agent and is used to treat infections caused by susceptible bacteria. Cefathiamidine exhibits a wide spectrum of antimicrobial activity against bacteria. Cefathiamidine is used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis.
  • HY-B1464
    Cetylpyridinium chloride

    Bacterial HBV Infection Inflammation/Immunology
    Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products.
  • HY-17647
    Zoliflodacin

    ETX0914; AZD0914

    DNA/RNA Synthesis Bacterial Infection
    Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.
  • HY-B1831A
    Oritavancin diphosphate

    LY333328 diphosphate

    Bacterial Antibiotic Infection Inflammation/Immunology
    Oritavancin diphosphate (LY333328 diphosphate) is an orally active glycopeptide antibiotic with activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial effect against multidrug-resistant S. pneumoniae. Oritavancin diphosphate inhibits cell wall synthesis and disrupts the membrane potential.
  • HY-A0208
    Rosoxacin

    Acrosoxacin

    Bacterial Antibiotic Infection
    Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC90=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment.
  • HY-139743
    Aditoprime

    Aditoprim

    Antifolate Bacterial Infection
    Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC50 of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics.
  • HY-N0328
    alpha-Mangostin

    α-Mangostin

    Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease Cancer
    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
  • HY-125703
    Ferutinin

    Estrogen Receptor/ERR Apoptosis Cancer Infection Endocrinology Inflammation/Immunology
    Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.
  • HY-13678A
    Meropenem trihydrate

    SM 7338 trihydrate

    Bacterial Antibiotic Infection
    Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
  • HY-146595
    FtsZ-IN-1

    Bacterial Infection
    FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce drug resistance. FtsZ-IN-1 has against drug-resistant bacteria activity.
  • HY-12820
    Sibofimloc

    Antibiotic-202

    Bacterial Antibiotic Infection
    Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD).
  • HY-B0909
    Triflupromazine hydrochloride

    Dopamine Receptor 5-HT Receptor Bacterial Autophagy Infection Neurological Disease
    Triflupromazine hydrochloride is an antipsychotic agent. Triflupromazine hydrochloride is Dopamine D1/D2 receptor antagonist and serotonin receptor 5-HT2 modulator. Triflupromazine hydrochloride also exhibits significant antibacterial activity against Gram-positive and Gram-negative bacteria.
  • HY-N1416
    Pogostone

    Bacterial Apoptosis Autophagy Infection Inflammation/Immunology
    Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy.
  • HY-N1347
    Robinetin

    3,3',4',5',7-Pentahydroxyflavone

    Fungal HIV Integrase Bacterial Infection
    Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation.
  • HY-B0537A
    Pentamidine dihydrochloride

    MP-601205 dihydrochloride

    Parasite Fungal Phosphatase Bacterial Antibiotic Cancer Infection
    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
  • HY-B0537
    Pentamidine

    MP-601205

    Parasite Fungal Phosphatase Bacterial Antibiotic Cancer Infection
    Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
  • HY-128913
    1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one

    Bacterial Infection
    1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one is an acridone alkaloid compound isolated from the fruits of Z. leprieurii and Z. zanthoxyloides. 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has antibacterial activity.
  • HY-N7057S2
    Nonanoic acid-d4

    Pelargonic acid-d4

    Bacterial
    Nonanoic acid-d4 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
  • HY-P3328
    MDP1

    Bacterial Infection
    MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa.
  • HY-N7057S1
    Nonanoic acid-d3

    Pelargonic acid-d3

    Bacterial
    Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
  • HY-P3328A
    MDP1 acetate

    Bacterial Infection
    MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa.
  • HY-N7057S
    Nonanoic acid-d17

    Pelargonic acid-d17

    Bacterial
    Nonanoic acid-d17 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
  • HY-125604
    WCK-4234

    Bacterial Infection
    WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases.
  • HY-117843
    Ppc-1

    Mitochondrial Metabolism Interleukin Related Bacterial Infection Metabolic Disease Inflammation/Immunology
    Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities.
  • HY-146165
    Metallo-β-lactamase-IN-8

    Bacterial Infection
    Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity.
  • HY-B1805
    Triclocarban

    3,4,4′-Trichlorocarbanilide

    Bacterial Infection
    Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.
  • HY-B0537C
    Pentamidine dimesylate

    MP-601205 dimesylate

    Antibiotic Parasite Fungal Phosphatase Bacterial Cancer Infection
    Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
  • HY-B0537B
    Pentamidine isethionate

    MP-601205 isethionate

    Parasite Fungal Phosphatase Bacterial Antibiotic Infection Cancer
    Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
  • HY-114936
    Piericidin A

    AR-054

    Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism Cancer Infection Neurological Disease
    Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.
  • HY-121071
    Ascamycin

    Bacterial Nucleoside Antimetabolite/Analog Infection
    Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively.
  • HY-P3350
    LS-BF1

    Infection
    LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model.
  • HY-B0470
    Neomycin sulfate

    Bacterial Antibiotic Phospholipase Infection
    Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.
  • HY-13678S
    Meropenem-d6

    SM 7338-d6

    Bacterial Antibiotic Infection
    Meropenem-d6 (SM 7338-d6) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
  • HY-B1257
    Cefmetazole sodium

    Sodium cefmetazole

    Bacterial Antibiotic Infection
    Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections.
  • HY-122337
    Streptolydigin

    Portamycin

    DNA/RNA Synthesis Bacterial Infection
    Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes.
  • HY-125733
    Thiocillin I

    Bacterial Infection
    Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively.
  • HY-B0425A
    Novobiocin Sodium

    Albamycin; Cathomycin

    Bacterial Autophagy Antibiotic Orthopoxvirus Infection Cancer
    Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC50=700 µM). Novobiocin Sodium shows anti-orthopoxvirus activity.
  • HY-W040265
    Fenamic acid

    N-Phenylanthranilic acid

    Chloride Channel Inflammation/Immunology
    Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent -.
  • HY-128780B
    SPR206 acetate

    Bacterial Antibiotic Infection
    SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L.
  • HY-133119
    PK150

    Bacterial Infection
    PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively.
  • HY-147522
    ADG-2e

    Bacterial Antibiotic Infection Cancer
    ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells.
  • HY-109008
    Nacubactam

    OP0595 free acid

    Bacterial Infection
    Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
  • HY-110354
    UCM05

    G28UCM

    Fatty Acid Synthase (FASN) Bacterial Antibiotic Cancer Infection
    UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli.
  • HY-10581A
    Gatifloxacin hydrochloride

    AM-1155 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride

    Bacterial Topoisomerase Antibiotic Infection
    Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
  • HY-116788
    Lipofermata

    Bacterial Infection
    Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC50 of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM.
  • HY-129555
    Surfactin

    Bacterial HSV Antibiotic Infection
    Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. Surfactin also has antiviral activity against a variety of enveloped viruses.
  • HY-10581B
    Gatifloxacin mesylate

    AM-1155 mesylate; BMS-206584 mesylate; PD135432 mesylate

    Bacterial Topoisomerase Antibiotic Infection
    Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin mesylate can be used to treat bacterial conjunctivitis in vivo.
  • HY-121300
    Kendomycin

    (-)-TAN2162

    Antibiotic Bacterial Endothelin Receptor CGRP Receptor Cancer Infection
    Kendomycin ((−)-TAN 2162) is a polyketide antibiotic with remarkable antibacterial and cancer cells cytotoxic activities. Kendomycin tends to be bacteriostatic rather than bactericidal and inhibits the growth of the methicillin-resistant Staphylococcus aureus (MRSA) strain COL at a low concentration (MIC of 5 μg/mL). Kendomycin is a potent antagonist of the endothelin receptor and a calcitonin receptor agonist which plays its role as an anti-osteoporotic agent.
  • HY-17395S
    Terbinafine-d3 hydrochloride

    TDT 067-d3 hydrochloride

    Fungal Bacterial Antibiotic Infection
    Terbinafine-d3 (TDT 067-d3) hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-N1029
    Norathyriol

    Mangiferitin

    Glucosidase PPAR Cancer Infection Inflammation/Immunology
    Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
  • HY-17395AS
    Terbinafine-d7

    TDT 067-d7

    Fungal Bacterial Antibiotic Infection
    Terbinafine-d7 (TDT 067-d7) is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-B0537AS
    Pentamidine-d4 dihydrochloride

    MP-601205-d4 dihydrochloride

    Parasite Fungal Phosphatase Bacterial Antibiotic Cancer Infection
    Pentamidine-d4 (MP-601205-d4) dihydrochloride is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
  • HY-113952
    Actinonin

    (-)-Actinonin

    Aminopeptidase Bacterial MMP Apoptosis Antibiotic Cancer Infection
    Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.
  • HY-N2229
    Rhapontigenin

    Cytochrome P450 Fungal Bacterial Cancer Infection Inflammation/Immunology
    Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50  = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively.
  • HY-10581
    Gatifloxacin

    AM-1155; BMS-206584; PD135432

    Bacterial Topoisomerase Antibiotic Infection
    Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50=0.109 μg/ml). Gatifloxacin can be used to treat bacterial conjunctivitis in vivo.
  • HY-124586
    Streptonigrin

    Bruneomycin

    Protein Arginine Deiminase Antibiotic Cancer Infection
    Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively.
  • HY-115990
    Topoisomerase IV inhibitor 1

    Topoisomerase Bacterial Infection
    Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively.
  • HY-17452
    Cefditoren sodium

    ME 1206

    Bacterial Infection Inflammation/Immunology
    Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
  • HY-10581C
    Gatifloxacin sesquihydrate

    AM-1155 sesquihydrate; BMS-206584 sesquihydrate; PD135432 sesquihydrate

    Bacterial Topoisomerase Antibiotic Infection Inflammation/Immunology
    Gatifloxacin sesquihydrate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin sesquihydrate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin sesquihydrate can be used to treat bacterial conjunctivitis in vivo.
  • HY-115991
    Topoisomerase IV inhibitor 2

    Topoisomerase Bacterial Infection
    Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively.
  • HY-17452A
    Cefditoren (Pivoxil)

    Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207

    Bacterial Antibiotic Infection Inflammation/Immunology
    Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
  • HY-10581AS
    Gatifloxacin-d3 hydrochloride

    AM-1155-d3 hydrochloride; BMS-206584-d3 hydrochloride; PD135432-d3 hydrochloride

    Bacterial Topoisomerase Antibiotic Infection
    Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
  • HY-145286
    IMPDH2-IN-2

    Others Cancer Infection
    IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent.
  • HY-B1805S
    Triclocarban-d4

    3,4,4′-Trichlorocarbanilide-d4

    Bacterial Infection
    Triclocarban-d4 (3,4,4′-Trichlorocarbanilide-d4) is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.
  • HY-N0328S
    Mangostin-d3

    Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease Cancer
    alpha-Mangostin-d3 (α-Mangostin-d3) is the deuterium labeled alpha-Mangostin. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
  • HY-146637
    VIM-2-IN-1

    Bacterial Infection
    VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC50 values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively.
  • HY-139554
    Zifanocycline

    KBP-7072

    Bacterial Infection
    Zifanocycline (KBP-7072) is a semisynthetic third-generation aminomethylcycline antibiotic that inhibits the normal function of the bacterial ribosome. Zifanocycline exhibits a broad spectrum of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline is available in both oral and injectable formulations. Zifanocycline can be used for the research of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections.
  • HY-N0930B
    Galegine hydrochloride

    AMPK Bacterial Infection Metabolic Disease
    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.
  • HY-125728
    Micrococcin P1

    Bacterial Parasite HCV Infection
    Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum.