Search Result
Results for "
antibacterial
" in MedChemExpress (MCE) Product Catalog:
2605
Inhibitors & Agonists
57
Biochemical Assay Reagents
157
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-141828
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- HY-141829
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Bacterial
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Infection
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Antibacterial agent 27 is a potent antibacterial compound against Candida species .
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- HY-W018811
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Bacterial
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Infection
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Antibacterial agent 268 (Compound 10e) is an antibacterial agent with antimycobacterial properties. Antibacterial agent 268 shows high anti-bacterial properties at sub-micromolar values (MIC=0.44-0.07 μM) .
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- HY-139757
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- HY-163708
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Antibiotic
Bacterial
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Infection
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Antibacterial agent (compound 8b) is a potent antibacterial agent. Antibacterial agent shows robust antibacterial efect on E. coli and S. aureus with IC50s of 64 and 32 µg/mL, respectively .
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- HY-161813
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Bacterial
Fungal
Topoisomerase
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Infection
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Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC50 value of 10.88 µM .
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- HY-162687
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Fungal
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Infection
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Antibacterial agent 232 (compound Y41) is a potent antibacterial agent. Antibacterial agent 232 disrupts the cell membrane integrity by inducing cell peroxidation .
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- HY-163104
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Bacterial
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Infection
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Antibacterial agent 169 (Compound 28) is a pyrrolamide-type GyrB/ParE inhibitor with antibacterial activity. Antibacterial agent 169 has an inhibitory effect on Gyrase and Topo IV of Staphylococcus aureus, with IC50 values of 49 nmol/L and 1.513 μmol/L respectively .
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- HY-168478
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Bacterial
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Infection
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Antibacterial agent 263 (compound 5a) is a potent antibacterial agent. Antibacterial agent 263 shows antibacterial activity for Streptococcus mutans, Staphylococcus aureus .
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- HY-174273
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Bacterial
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Infection
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Antibacterial agent 280 (Compound 7af) is an antibacterial agent targeting methicillin-resistant and vancomycin-resistant Staphylococcus aureus (MRSA, VRSA). Antibacterial agent 280 is promising for research of is promising for research of S. aureus infections .
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- HY-176144
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Bacterial
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Infection
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Antibacterial agent 278 (compound B1) is an antibacterial agent. Antibacterial agent 278 exhibites potent activity against Gram-positive bacteria .
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- HY-162451
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Bacterial
Reactive Oxygen Species (ROS)
Glycosidase
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Infection
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Antibacterial agent 207 (Compound Ru1) has antibacterial activity against S. aureus (MIC: 1 μg/mL), and low resistance frequencies. Antibacterial agent 207 destroys the bacterial cell membrane, promote production of ROS in bacteria .
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- HY-161172
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Bacterial
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Infection
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Antibacterial agent 178 (compound A10) is a potent antibacterial agent. Antibacterial agent 178 shows antibacterial activities for Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola with EC50s of 5.32 mg/L and 7.58 mg/L, respectively. Antibacterial agent 178 targets the translational regulator (CsrA) and the virulence regulator (Xoc3530) .
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- HY-162261
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Bacterial
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Infection
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Antibacterial agent 186 (compound 25) is a potent antibacterial agent. Antibacterial agent 186 shows antibiofilm-forming properties against clinical Staphylococcus epidermidis strains and demonstrates the capacity to eliminate existing biofilm layers. Antibacterial agent 186 has the potential for the research of multidrug-resistant Staphylococcus epidermidis .
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- HY-146400
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Bacterial
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Infection
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Antibacterial agent 97 (hit compound) is a potent antibacterial agent. Antibacterial agent 97 shows antibacterial activities with MIC of 16 and 16 µg/mL for Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively .
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- HY-173080
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Bacterial
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Infection
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Antibacterial agent 267 (Compound h19) is a pleuromutilin derivative with a potent antibacterial activity on Gram-positive bacteria. Antibacterial agent 267 shows an antibacterial activity in methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse models .
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- HY-W018629
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Bacterial
Drug Intermediate
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Infection
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Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans .
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- HY-162527
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Bacterial
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Infection
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Antibacterial agent 216 (Compound 2a) is an antibacterial agent that exhibits significant bactericidal effects when combined with INH and RIF. Antibacterial agent 216 has demonstrated remarkable in vitro anti-tuberculosis activity against Mtb H37Rv and MDR clinical isolates and can be used for tuberculosis research .
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- HY-142545
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Bacterial
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Infection
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Antibacterial agent 68 (compound 4d) is an antibacterial agent against drug-resistant Escherichia coli. Antibacterial agent 68 has low cytotoxicity and exerts strong antibacterial activities against multidrug-resistant Escherichia coli at low concentrations as 0.007 mM .
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- HY-126629
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Bacterial
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Infection
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Antibacterial agent 12, a biaryloxazolidinone analogue, is an antibacterial agent against antibiotic-susceptible and antibiotic-resistant Gram-positive bacteria .
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- HY-151918
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Bacterial
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Infection
Inflammation/Immunology
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Antibacterial agent 125 is an antibacterial agent. Antibacterial agent 125 has a potent antimicrobial activity against clinically relevant Gram-positive pathogens with MIC50 values range from 0.25 - 8 μM. Antibacterial agent 125 can be used for the research of antimicrobial resistance .
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- HY-163111
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Bacterial
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Infection
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Antibacterial agent 170 (compound 6b) is a potent antibacterial agent which inhibits the formation of P. aeruginosa PAO1 biofilm. Antibacterial agent 170 exhibits quorum sensing inhibitor effect by the las system. Antibacterial agent 170 can used in study microbial resistance .
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- HY-157808
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Bacterial
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Infection
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Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .
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- HY-136861
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Bacterial
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Infection
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Antibacterial agent 192 is an antibacterial agent that can disrupt iron homeostasis in E. coli .
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- HY-148576
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Antibiotic
Bacterial
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Infection
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Antibacterial agent 136 (compound 3) is an antibiotic of oxadiazolones. Antibacterial agent 136 have high antibacterial potency against Staphylococcus aureus (MRSA) with a MIC50 value of 0.8 μM .
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- HY-149095
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Bacterial
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Infection
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Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane .
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- HY-157043
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Bacterial
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Infection
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Antibacterial agent 161 trifluoromethanesulfonate (Compound 6) has antibacterial activity. Antibacterial agent 161 trifluoromethanesulfonate has high antiproliferative effects against colon cancer and non-small cell lung cancer .
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- HY-169161
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Bacterial
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Infection
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Antibacterial agent 245 (Dc-2) is an antibacterial against plant pathogen fungi and bacteria with an EC50 value of 1.29 μg/mL for Botrytis cinerea .
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- HY-151356
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Bacterial
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Infection
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Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .
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- HY-149089
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Bacterial
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Infection
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Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls .
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- HY-139747
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Bacterial
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Infection
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Antibacterial agent 32 (example 43) is an antibacterial agent with MIC values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .
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- HY-139767
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Bacterial
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Infection
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Antibacterial agent 50 (example 47) is an antibacterial agent with MIC values of 32 mcg/mL, 64 mcg/mL, and 128 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .
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- HY-139768
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Bacterial
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Infection
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Antibacterial agent 51 (example 45) is an antibacterial agent with MIC values of 4 mcg/mL, 8 mcg/mL, and 8 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .
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- HY-112240
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Antibiotic
Bacterial
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Infection
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Antibacterial agent 104 (Compound 7) is a potent antibacterial agent. Antibacterial agent 104 displays excellent antibacterial activity in vitro and good efficacy in vivo against MRSA .
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- HY-162271
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Topoisomerase
Fungal
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Infection
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Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL .
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- HY-162130
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Bacterial
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Infection
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Antibacterial agent 176 (Compound 6f) is a potent PqsR antagonist. Antibacterial agent 176 has a good inhibitory effect on P. aeruginosa CF, and a significant inhibitory effect on the production of pyocyanin, 2-alkyl-4 (1H) -quinolones .
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- HY-161263
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Bacterial
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Infection
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Antibacterial agent 182 (compound 8c) is an antibacterial agent that shows antibacterial activity against various Gram-positive bacteria, particularly against Vancomycin-resistant Enterococcus faecalis (MIC ≤0.125 μg/mL). Antibacterial agent 182 inhibits biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa at sub-MIC doses .
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- HY-168626A
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Bacterial
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Infection
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Antibacterial agent 252 hydrochloride is an amino acid derivative with antibacterial activity. Antibacterial agent 252 hydrochloride enhances the killing of colistin sulfate (HY-A0089) against a variety of gram-negative bacteria by targeting the bacterial membrane .
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- HY-170688
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Bacterial
Reactive Oxygen Species (ROS)
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Infection
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Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin (HY-121544)-resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains). Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity .
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- HY-162171
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Bacterial
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Infection
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Antibacterial agent 179 (Compound 23) is a potent antibacterial agent, which effectively kills both Gram-negative and Gram-positive bacteria. Antibacterial agent 179 shows potent in vivo antibacterial efficacy in murine corneal infection models caused by Staphylococcus aureus or Pseudomonas aeruginosa .
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- HY-147835
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Bacterial
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Infection
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Antibacterial agent 109 (Compound C-2) is a potent antibacterial agent against both gram-positive and gram negative bacteria, and non-mutagenic. Antibacterial agent 109 inhibits protein synthesis by blocking the extension of new peptide chains .
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- HY-155250
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Bacterial
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Infection
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Antibacterial agent 154 (compound 7) is a derivative of Fluoroqinolones and is an orally effective antibacterial agent. Antibacterial agent 154 inhibits Gram-positive and Gram-negative bacteria. Antibacterial agent 154 demonstrated in vivo efficacy in a mouse model of staphylococcal sepsis .
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- HY-149983
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Bacterial
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Infection
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Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC50 value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability.
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- HY-146059
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Bacterial
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Infection
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Antibacterial agent 99 (compound 7b) is a potent antibacterial agent. Antibacterial agent 99 shows significant antibacterial and antifungal activity. Antibacterial agent 99 dose not show haemolytic activity .
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- HY-163630
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Bacterial
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Infection
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Antibacterial agent 217 (Compound 24) is a non-cytotoxic, non-hemolytic, moderately active antibacterial agent that inhibits the growth of Staphylococcus aureus strains with a minimum inhibitory concentration (MIC) of 32 μg/mL. Antibacterial agent 217 also moderately inhibits the growth of Staphylococcus epidermidis .
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- HY-155357
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Bacterial
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Infection
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Antibacterial agent 160 is a potent antibacterial agents. Antibacterial agent 160 can rapidly kill bacterial and inhibits bacterial biofilm formation. Antibacterial agent 160 affects the normal function of DNA and leads cell death .
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- HY-141648
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Bacterial
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Infection
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Antibacterial agent 219 (Compound 2/75c) exhibits antibacterial activity by targeting cell wall biosynthesis. Antibacterial agent 219 inhibits methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC=0.5-32 µg/mL), Enterococcus faecium (MIC=2 µg/mL) and S. aureus (MIC=2 µg/mL) .
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- HY-139971
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Bacterial
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Infection
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Antibacterial agent 64 (compound 62) is a potent YycG inhibitor (IC50=6.1 µM) and an antibacterial agent. Antibacterial agent 64 combines with ampicillin could synergistically eradicate the biofilm-embedded viable bacteria .
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- HY-174326
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Antibiotic
Bacterial
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Infection
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Antibacterial agent 282 (Compound CP7), a seleno-Ciprofloxacin (HY-B0356) derivative, is an Antibacterial agent. Antibacterial agent 282 has significant antibacterial activity against gram-positive bacterium and gram-negative bacterium with MICs of 0.1-1.56 and 0.1-3.13 μg/mL, respectively (MBCs of 0.2-1.56 and 0.39-12.5 μg/mL). Antibacterial agent 282 potently disrupts and prevents biofilms formation of P. aeruginosa. Antibacterial agent 282 shows significant inhibitory activity towards the DNA gyrase from E. coli .
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- HY-174158
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Bacterial
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Infection
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Antibacterial agent 270 (Compound 3e) is an antibacterial agent that acts on bacterial membrane components phosphatidylglycerol (PG), cardiolipin (CL), and bacterial DNA. Antibacterial agent 270 disrupts bacterial membrane structure and binds to DNA to interfere with genetic information transmission. Antibacterial agent 270 is promising for research of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) .
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- HY-161797
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Aminoacyl-tRNA Synthetase
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Infection
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Antibacterial agent 227 (Compd 29) is a SerRS (Seryl-tRNA synthetase) inhibitor. Antibacterial agent 227 has a significant inhibitory effect on the growth of planktonic and biofilm culture of Staphylococcus aureus 25923 with MIC (minimum inhibitory concentration) value of 32 µg/ml. Antibacterial agent 227 can be proposed as effective antiseptic toward multidrug-resistant biofilm-forming S. aureus isolates .
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- HY-146098
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Bacterial
Antibiotic
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Infection
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Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC90=2.64 μM). Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC90s of 11.18, 11.18, 0.70, 1.40, 44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes and S. aureus, respectively .
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- HY-138621
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Bacterial
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Infection
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Antibacterial agent 19 (compound 8) is a potent antibacterial agent. Antibacterial agent 19 has antibacterial activity against K. pneumoniae, (M-R)S. aureus and (M-R,V-R)S. aureus with MIC values of 0.022, 0.022 and 0.045 mg/mL, respectively .
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- HY-143292
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Bacterial
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Infection
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Antibacterial agent 81 is a DNA transcription inhibitor. Antibacterial agent 81 inhibits S. aureus USA300 and M. smegmatis ATCC14468 with MIC values of 12.5 and 7.8 μM, respectively. Antibacterial agent 81 can be used for the research of infection .
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- HY-170401
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Bacterial
Herbicide
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Infection
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Antibacterial agent 260 (Compound 4r) exhibits board-spectrum antibacterial activity, inhibits P. aeruginosa and S. aureus with MIC of 0.0076 μM. Antibacterial agent 260 acts as a herbicidal agent, that inhibits the root- and stem-growth of Raphanus sativus L. (radish seed) .
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- HY-146591
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Bacterial
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Infection
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Antibacterial agent 87 (Compound 4h) is a potent antibacterial agent with MIC values of 0.125, 0.0625 and 0.0625 μg/mL against MRSA, MRSE and S. aureus, respectively .
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- HY-146593
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Bacterial
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Infection
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Antibacterial agent 88 (Compound 5h) is a potent antibacterial agent with MIC values of both ≤0.0156 μg/mL against MRSA, MRSE and S. aureus. Antibacterial agent 88 also inhibits B. subtilis with an MIC of 4 μg/mL .
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- HY-162418
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Bacterial
Fungal
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Infection
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Antibacterial agent 203 (Compound 5h) has antibacterial and antifungal activity. Antibacterial agent 203 has potent antifungal activity against C. albicans, with a MIC of 3.90 μg/mL. Antibacterial agent 203 has antimicrobial activity on healthy mouse fibroblast cells (L929), with an IC50 of 75.96 μM .
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- HY-161258
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Bacterial
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Infection
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Antibacterial agent 181 (Compound 3f) is a potent ciprofloxacin cationic antibacterial agent with low cytotoxicity. The MIC values of Antibacterial agent 181 against Staphylococcus aureus and Escherichia coli are both 2 μg/mL .
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- HY-161689
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Bacterial
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Infection
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Antibacterial agent 220 is a potent antibacterial agent that can directly destroy bacterial cell membranes. Antibacterial agent 220 effectively combats Gram-positive and and Gram-negative pathogens, including drug-resistant strains .
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- HY-146062
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Bacterial
Fungal
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Infection
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Antibacterial agent 101 (Compd 7f) is an antimicrobial (antibacterial and antifungal) agent, with MIC values between 4 and 32 µg/mL .
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- HY-W282615
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Bacterial
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Infection
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Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection .
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- HY-143326
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Bacterial
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Infection
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Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes .
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- HY-168042
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Bacterial
Fungal
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Infection
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Antibacterial agent 243 is an antibacterial agent, with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells .
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- HY-168881
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Bacterial
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Infection
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Antibacterial agent 262 (compound A23) is a potent antibacterial agent. Antibacterial agent 262 inhibits Xanthomonas oryzae pv oryzae activity. Antibacterial agent 262 inhibits the formation of Xanthomonas oryzae pv oryzae biofilms, disrupting the integrity of bacterial cell membranes .
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- HY-162564
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Antibiotic
Bacterial
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Infection
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Antibacterial agent 221 (compound 3k) is a potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 221 shows significant cytotoxicity against human LO2 and HepG2 cells .
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- HY-168674
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Bacterial
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Infection
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Antibacterial agent 255 (compound (±)-1) is a potent antibacterial agent. Antibacterial agent 255 is a potent and selective 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE) inhibitor with IC50 values of 13.0, 8.0, 20 µM for EclspE, KplspE, AblspE, respectively .
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- HY-157143
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Bacterial
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Infection
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Antibacterial agent 164 (compound 2a) is an antibacterial and antibiofilm agent. Antibacterial agent 164 inhibits S. aureus and B. subtilis (MIC of 0.09 mM), and also exhibits strong anti-B. Subtilis biofilm formation .
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- HY-146403
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Bacterial
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Infection
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Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus) .
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- HY-146060
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Bacterial
Fungal
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Infection
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Antibacterial agent 100 (Compound 7c) is an antibacterial and antifungal agent. Antibacterial agent 100 shows promising activity with MIC values of 4, 4 and 8 μg/mL against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans, respectively .
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- HY-155682
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Bacterial
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Infection
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Antibacterial agent 150 (compound 5g) is an antibacterial agent with potent antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria (MIC values ranging from 1-32 μg/mL). Antibacterial agent 150 can increase survival rate of MRSA (Methicillin-resistant Staphylococcus aureus)-infected mice .
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- HY-168631
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Bacterial
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Infection
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Antibacterial agent 254 (Compound 2) is a dispersion sensor (DspS) activator that disperses Pseudomonas aeruginosa biofilms. Antibacterial agent 254 can dislodge 7-day P. aeruginosa biofilms at 50 μM. Antibacterial agent 254 also enhances the effects of Ciprofloxacin (HY-B0356) against P. aeruginosa and increases the expression of matrix-degrading enzyme genes pelA, pslG and eddA .
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- HY-174313
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Bacterial
Toll-like Receptor (TLR)
Collagen
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Infection
Inflammation/Immunology
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Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .
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- HY-146470
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Bacterial
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Infection
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Antibacterial agent 103 (compound 7) has highly antibacterial activity against kinds of Gram-positive and -negative bacteria. Antibacterial agent 103 can be used for researching inhibition of resistance bacterial strains .
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- HY-174852
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Antibiotic
Bacterial
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Infection
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Antibacterial agent 285 (Compound 3) is a cephalosporin antibiotic. Antibacterial agent 285 has significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. Antibacterial agent 285 can be used for bacterial infection research, such as complicated urinary tract infections (cUTI) and kidney infections .
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- HY-168844
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Bacterial
Reactive Oxygen Species (ROS)
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Infection
|
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Antibacterial agent 259 (K3) is a bactericide, with EC50 values of 1.5, 1.7 and 4.9 mg/L for Xoo, Xoc and Xac, respectively. Antibacterial agent 259 can induce pathogens to produce reactive oxygen species (ROS), leading to their death. Antibacterial agent 259 can be used in the prevention and control of plant bacterial diseases .
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- HY-151567
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Bacterial
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Infection
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Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria .
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- HY-150063
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Penicillin-binding protein (PBP)
Bacterial
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Infection
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Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain .
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- HY-161364
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Bacterial
|
Inflammation/Immunology
|
|
Antibacterial agent 200 (pyridyl HH 7), a unique hydrazyl hydroxycoumarin (HH), has strong antibacterial efficacy and broad antibacterial spectrum with MIC values ranging from 0.5 to 32 μg/mL for Gram-positive and Gram-negative bacteria. Antibacterial agent 200 exhibits a good inhibition against Pseudomonas aeruginosa 27853 with a low MIC value of 0.5 μg/mL. Antibacterial agent 200 can eradicate the integrity of bacterial membrane, result in the leakage of intracellular proteins, and interact with bacterial DNA gyrase via non-covalent binding .
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-
- HY-162672
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 231 (derivative 8) is an antimicrobial agent against multidrug-resistant Helicobacter pylori (H. pylori) with a minimum inhibitory concentration of 0.25–0.5 μg/mL. Antibacterial agent 231 directly targets the protein transposase subunit SecA and the outer membrane protein assembly factor BamD to inhibit the trafficking and assembly of bacterial outer membrane proteins (OMPs). Antibacterial agent 231 can be used to study the effects of antibiotic treatment on intestinal microbial balance .
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-
- HY-162818
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/mL. Antibacterial agent 237 destroys bacterial cell membranes, changes their permeability, and induces bacteria to produce Reactive Oxygen Species, leading to bacterial death without causing drug resistance. Antibacterial agent 237 has low hemolytic toxicity to rabbit red blood cells and Raw 264.7 cells, and has significant antibacterial effects against Staphylococcus aureus in mouse skin wound infection models and Bacillus major larvae infection models .
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-
- HY-163342
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 190 (compound 16) is a antibacterial agent. Antibacterial agent 190 shows antibacterial activity. Antibacterial agent 190 reduces the bacterial burden of the peritoneum and blood .
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-
- HY-146047
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 94 (compound 5b) is a potent antibacterial agent. Antibacterial agent 94 show antibacterial activities and show the capability of eradicating MRSA persisters. Antibacterial agent 94 has an effect on bacterial membrane. Antibacterial agent 94 interferes in phosphatidylglycerol (PG) synthesis pathway .
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-
- HY-139750
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 35, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
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-
- HY-139764
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 47, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139765
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 48, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139752
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 35, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139749
-
|
|
Bacterial
|
Cancer
|
|
Antibacterial agent 33, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139759
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 42, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139775
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 58, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139756
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 39, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139777
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 60, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-139762
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 45, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime .
|
-
- HY-146722
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription .
|
-
- HY-161097
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 171 (Compound 28) is an antibacterial agent. Antibacterial agent 171 inhibits gram-negative bacteria .
|
-
- HY-156005
-
|
|
Bacterial
|
Others
|
|
Antibacterial agent 153 is a broad-spectrum antibacterial agent. Antibacterial agent 153 kills bacteria by acting on the bacterial cell membrane. Antibacterial agent 153 can be used for bacterial infections research .
|
-
- HY-151925
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 126 is a potent antibacterial agent. Antibacterial agent 126 reduces the burden of biofilm to avoid developing agent resistance. Antibacterial agent 126 disturbs the membrane integrity and leads to the leakage of intracellular materials. Antibacterial agent 126 increase in ROS and reactive nitrogen species (RNS) production .
|
-
- HY-149286
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 142, an aromatic hydrazidesis, has antibacterial activity. Antibacterial agent 142 has bacteriostatic and inhibits biofilm formation .
|
-
- HY-144621
-
-
- HY-172976
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 279 (compound A12) is a potent antibacterial agent. Antibacterial agent 279 inhibits Pseudomonas aeruginosa SOS response .
|
-
- HY-145877
-
-
- HY-145878
-
-
- HY-145875
-
-
- HY-145874
-
-
- HY-145876
-
-
- HY-173417
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 275 (Ⅲ1) is a antibacterial agent, with a λmax of 730 nm. Antibacterial agent 275 (Ⅲ1) can be used in the research for antimicrobial photodynamic therapy (aPDT) .
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-
- HY-147546
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 107 (compound 14) is a potent antibacterial agent. Antibacterial agent 107 shows potent antibacterial activity against Gram-positive bacteria, with a MIC of 1.56 μg/mL (MRSA). Antibacterial agent 107 exhibits low hemolytic activity, high membrane selectivity, and rapid bactericidal activity. Antibacterial agent 107 shows effective in vivo efficacy in the murine model of bacterial keratitis caused by Staphylococcus aureus ATCC29213 .
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-
- HY-143643
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 72 displays the antibacterial activities by targeting the bacterial membrane.
|
-
- HY-151937
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 127 (Compound 23) is a potent antibacterial agent .
|
-
- HY-144729
-
-
- HY-139754
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 37 is an antibacterial agent extracted from patent WO2015063714A1, compound B. Antibacterial agent 37 can be used for the research of bacterial infections .
|
-
- HY-151354
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research .
|
-
- HY-139755
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 38 is an antibacterial agent extracted from patent WO2015063714A1, compound C. Antibacterial agent 38 can be used for the research of bacterial infections .
|
-
- HY-139761
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 44 is an antibacterial agent extracted from patent WO2013030735A1, example 7. Antibacterial agent 44 can be used for the research of bacterial infections .
|
-
- HY-139763
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 46 is an antibacterial agent extracted from patent WO2013030735A1, example 9. Antibacterial agent 46 can be used for the research of bacterial infections .
|
-
- HY-139760
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 43 is an antibacterial agent extracted from patent WO2013030735A1, example 6. Antibacterial agent 43 can be used for the research of bacterial infections .
|
-
- HY-162328
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 194 (Compound 19) is an antibacterial agent. Antibacterial agent 194 has potent anti-Mycobacterium tuberculosis (anti-Mtb) activity (MIC = 1 μg/mL) .
|
-
- HY-146374
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells .
|
-
- HY-152249
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production .
|
-
- HY-149801A
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride also possessed robust antibacterial activity for G+ under light irradiation .
|
-
- HY-139739
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 31 shows the antibacterial activity against rice bacterial leaf streak.
|
-
- HY-162430
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 206 (Compound 10e) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-1 μg/mL. Antibacterial agent 206 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 206 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication .
|
-
- HY-163843
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 234 (6p) is an antibacterial agent. Antibacterial agent 234 (6p) exhibits good activity against Klebsiella pneumoniae with a MIC value of 6.25 µg/mL .
|
-
- HY-147958
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 113 (compound 3) is a potent antibacterial agent. Antibacterial agent 113 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values all of 156.25 μM .
|
-
- HY-162113
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 174 (Compound 5g) is a antibacterial agent. Antibacterial agent 174 has potent anti-infective potential in vivo and appreciable pharmacokinetic profiles. Highly active antibacterial agent 174 has favorable biofilm removal performance, low hemolysis and acceptable mammalian cell toxicity .
|
-
- HY-162429
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 205 (Compound 10d) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-0.5 μg/mL. Antibacterial agent 205 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 205 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication .
|
-
- HY-150002
-
-
- HY-162296
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity .
|
-
- HY-101819
-
|
|
Bacterial
|
Infection
|
|
Antibacterial compound 1 is a oxazolidinone extracted from patent WO1999037630A1 with antibacterial activities.
|
-
- HY-148831
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 135 (example 7) is a potent antibacterial agent. Antibacterial agent 135 can inhibit P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae, with MIC>64 μg/mL .
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-
- HY-147531
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages . Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-173190
-
|
|
Bacterial
DNA/RNA Synthesis
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 271 is an antibacterial agent with significant inhibition against Escherichia coli (MIC: 2.2 μM). Antibacterial agent 271 reduces metabolic activity by disrupting the integrity of bacterial membranes. Antibacterial agent 271 binds to DNA grooves to inhibit replication and induces accumulation of reactive oxygen species (ROS) , ultimately leading to bacterial death. Antibacterial agent 271 shows significant potential in combating bacterial infections .
|
-
- HY-147866
-
|
|
Bacterial
DNA/RNA Synthesis
ROS Kinase
|
Infection
|
|
Antibacterial agent 110 (Compound 4e) is a potent antibacterial agent with a MIC value of 1 μg/mL against P. aeruginosa. Antibacterial agent 110 possesses favorable antibiofilm activity and can destroy cell membranes. Antibacterial agent 110 causes metabolic arrest and intracellular oxidative stress, and obstructs DNA replication .
|
-
- HY-139776
-
-
- HY-139766
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 49 (example 12) is a antibacterial agent (extracted from patent WO2013030735A1) .
|
-
- HY-139758
-
-
- HY-139769
-
-
- HY-139771
-
-
- HY-101730
-
|
|
Bacterial
|
Infection
|
|
Antibacterial compound 2 is a useful antibacterial agent extracted from patent US5652238, compound example 9.
|
-
- HY-139778
-
-
- HY-139774
-
-
- HY-139770
-
-
- HY-139679
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 28 is a potential antibacterial candidate for combating MRSA infections (MICs = 0.5–2 μg/mL).
|
-
- HY-139772
-
-
- HY-139773
-
-
- HY-149615
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 157 (compound B12) is a fungicidal agent. Antibacterial agent 157 can influence the protein synthesis of Botrytis cinerea. Antibacterial agent 157 can be used for gray mold resistance control research .
|
-
- HY-147957
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively .
|
-
- HY-170760
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 258 (Compound 11e) is an antibacterial agent, that destory the bacteria cell membrane, and inhibits various gram-positive bacteria (MIC for Staphylococcus aureus is 1-2 μg/mL). Antibacterial agent 258 exhibits low hemolytic activity and low cytotoxicity. Antibacterial agent 258 exhibits anti-infectious efficacy in mouse models .
|
-
- HY-147959
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 114 (compound 1) is a potent antibacterial agent. Antibacterial agent 114 shows antibacterial activity against P.aeruginosa, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, S.mutans, and S.aureus microorganisms, with MIC values of 625, 625, 625, 625, 625, 1250 and 1250 μM, respectively .
|
-
- HY-155060
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Antibacterial agent 144 (compound 8e) is an antibacterial agent，with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin (HY-B0467A). Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria，and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 μM)，and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications .
|
-
- HY-160669
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 198 (Compound 16) is an antibacterial agent against gram positive Staphylococcus aureus and strains of Entercoccus .
|
-
- HY-149353
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 145 (compound 1b) is an antibacterial agent depending on bacterial iron uptake pathway. Antibacterial agent 145 disrupts cytoplasmic membrane integrity and inhibits cell metabolism but exhibits low cytotoxic effects to normal cells .
|
-
- HY-144255
-
|
|
ROS Kinase
|
Inflammation/Immunology
|
|
Antibacterial agent 70 is a new dihydropyrimidinone imidazole hybrid antibacterial agent, and its < b > MIC < / b > value is 0.5 μg/mL
|
-
- HY-147878
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 111 (Compound 3) is an antibacterial agent with MIC values of 3.90 μg/mL and 0.49 μg/mL against B. cereus and K. pneumonia, respectively. Antibacterial agent 111 firmly binds with tyrosyl-tRNA synthetase residues .
|
-
- HY-157044
-
|
|
Bacterial
|
Infection
Cancer
|
|
Antibacterial agent 162 trifluoromethanesulfonate (compound 7) is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus, including MRSA. Antibacterial agent 162 trifluoromethanesulfonate is also an anticancer agent and exhibits antiproliferative activity against colon cancer and non-small cell lung cancer cells. Antibacterial agent 162 trifluoromethanesulfonate can be used in anticancer and antibacterial research .
|
-
- HY-N10572
-
|
|
Bacterial
|
Infection
|
|
Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .
|
-
- HY-163762
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 226 (Compound 7f) is an antibacterial agent, that inhibits Staphylococcus aureus strains and methicillin-resistant S. aureus strain with MIC of 2 μg/mL. Antibacterial agent 226 exhibits cytotoxicity to HEK293 with IC50 of 1.9 μM .
|
-
- HY-161937
-
|
|
Topoisomerase
Bacterial
|
Infection
|
|
Antibacterial agent 236 (Compound 4l) is an orally active inhibitor for DNA gyrase and topoisomerase IV (IC50 is 3.2 and 300 nM in Staphylococcus aureus), and exhibits board-spectrum antibacterial activity. Antibacterial agent 236 exhibits good pharmacokinetic properties in mice .
|
-
- HY-161300
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 191 (compound 11a) is a potent semi-synthetic antibiotic. Antibacterial agent 191 exhibits preferable metabolic stability .
|
-
- HY-146458
-
|
|
Bacterial
Cytochrome P450
|
Infection
|
|
Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice .
|
-
- HY-156283
-
|
|
Antibiotic
|
Infection
|
|
Antibacterial agent 159 (Compound 6d) is an antibiotic. Antibacterial agent 159 can effective against impetigo and C. difficile infection (CDI). Antibacterial agent 159 has no observed recurrence for C. difficile and exertes a minimal impact on the beneficial gut microbiome .
|
-
- HY-174407
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 281 (Compound 95,186) can bacteriostatically inhibits the growth of GAS. Antibacterial agent 281 binds to the ligand binding pocket of SPs0871 and competes with the ligand. Antibacterial agent 281 shows concentration-dependent growth inhibition against S. pyogenes .
|
-
- HY-143290
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 118 (compound 20) is an antimycobacterial agent. Antibacterial agent 118 shows antibacterial activity against Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv and M. avium with MIC values of 40.7, 10.2, 163.0, 62.5 and 62.5 μM, respectively. Antibacterial agent 118 can be used for the research of tuberculosis .
|
-
- HY-163984
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 240 (compound 62-7c) is an antibacterial agent that can target multidrug-resistant (MDR) MRSA strains. Antibacterial agent 240 showed high biosafety and potent anti-infection activity in mouse pneumonia and mouse wound models of MRSA infection .
|
-
- HY-146199
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 108 (Compound 1h) is a potent antibacterial agent with a MIC of both 3 μM against MRSA and antibiotic resistance strains .
|
-
- HY-143232
-
|
|
Fungal
Bacterial
|
Infection
Cancer
|
|
Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM .
|
-
- HY-152139
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 129, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis and B. subtilis with MICs of 31.25 μM and 31.5 μM and . Antibacterial agent 129 shows good antifungal activity against A. niger with a MIC of 31.25 μM. Antibacterial agent 129 shows excellent antimycobacterial activity with MIC 57.73 μM for M. tuberculosis H37Rv .
|
-
- HY-142695
-
|
|
Bacterial
|
Infection
|
|
Antibacterial synergist 1 (compound 20P) is a bacterial biofilm inhibitor. Antibacterial synergist 1 inhibits the production of pyocyanin and biofilm formation with IC50s of 8.6 and 4.5 μM, respectively. Antibacterial synergist 1 has the potential for the research of P. aeruginosa infections .
|
-
- HY-157142
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 165 (compound 3), a hydroxyquinoline derivative, is a potent bacterial inhibitor. Antibacterial agent 165 inhibits methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-157141
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 163 (compound 1), a hydroxyquinoline derivative, is a potent bacterial inhibitor. Antibacterial agent 163 inhibits methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-163399
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 197 (compound 1-deAA) is a termination inhibitor of non-classical anhydroglycosyl receptors and anhydrowall peptide-type peptidoglycan (PG) in bacterial TGase, with activity against Staphylococcus aureus. Antibacterial agent 197 synergizes with Vancomycin (HY-B0671) and is its antibacterial adjuvant .
|
-
- HY-169065
-
|
|
Bacterial
|
Infection
|
Antibacterial agent 241 is a histidine kinase (HK) inhibitor, with IC50 values of 14 μM and 238 μM for CckA and PhoQ, respectively. Antibacterial agent 241 shows moderate antibacterial activity against E. coli DC2, Bacillus cereus, and Bacillus subtilis, with a MIC range of 12-74 μg/mL .
|
-
- HY-161728
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 223 (compound D8-03) is an inhibitor of Francisella tularensis. Antibacterial agent 223 can inhibit intracellular growth of Francisella tularensis in mice .
|
-
- HY-163353
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antibacterial agent 193 (Compound 2n) is A monobenzene derivative of spiromarone A, which has antibacterial activity against Rhizoctonia solani. with IC50 value of 5.25 μg/mL .
|
-
- HY-125524
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .
|
-
- HY-161822
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 230 (compound 10) is an effective Antifungal agent. The MIC value of antibacterial agent 230 against fluconazole-resistant fungi is 2.0 ~ 16.0 μg/mL .
|
-
- HY-162923
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 244 is an orally active compound with broad-spectrum antibacterial activity, primarily targeting Gram-positive bacteria, with a MIC value of 1–4 μg/mL and low hemolytic toxicity (HC50 of 111.6 μg/mL). Antibacterial agent 244 disrupts bacterial transmembrane potential, increases membrane permeability, leading to leakage of cellular contents such as DNA and proteins, ultimately causing bacterial death. Antibacterial agent 244 can be used in research related to Gram-positive bacterial infections .
|
-
- HY-161860
-
|
|
Bacterial
|
Cancer
|
|
Antibacterial agent 233 (Compound 7c) exhibits inhibitory efficacy against Helicobacter pylori with MIC of 0.4-1.6 μg/mL. Antibacterial agent 233 inhibits jack bean urease (IC50 is 0.27 μg/mL), changes the permeability of H. pylori cell membrane, causes the leakage of cellular contents. Antibacterial agent 233 exhibits metabolic stability in whole blood and artificial gastric fluid. Antibacterial agent 233 exhibits antitumor efficacy against U2OS in mice .
|
-
- HY-162273
-
|
|
Bacterial
Smo
Gli
|
Infection
Cancer
|
|
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .
|
-
- HY-172793
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
Apoptosis
|
Infection
|
|
Antibacterial agent 276 (compound B3) is an antibacterial agent with EC50 values of 1.32 μg/mL and 2.80 μg/mL against Xanthomonas oryzae pv.oryzae and Xanthomonas axonopodis pv.citri，respectively. Antibacterial agent 276 disrupts the intracellular redox balance, and results in the accumulation of reactive oxygen species (ROS) and subsequent induction of apoptosis .
|
-
- HY-161922
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 235 (compound thy2I) shows antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.5 μg/mL to 8 μg/mL. Antibacterial agent 235 could kill both gram-positive and gram-negative bacteria via a membrane-targeting mechanism of action with a low frequency of resistance .
|
-
- HY-W681949
-
-
- HY-168109
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Antibacterial agent 246 (compound A33) is a antibacterial agent and has minimum inhibitory concentrations (MICs) of 0.5-4 μg/mL against twenty-three Gram-positive bacteria. Antibacterial agent 246 in combination with Polymyxin E(HY-113678) E inhibits the growth of various Gram-negative bacteria with the fractional inhibitory concentration index of 0.066 .
|
-
- HY-161028
-
|
|
Carbonic Anhydrase
Bacterial
|
Infection
|
|
Antibacterial agent 167 (compound 13) is an inhibitor of pathogenic bacterial carbonic anhydrases. Antibacterial agent 167 inhibits the growth of N. gonorrhea strains at concentrations ranging from 16 to 64 µg/mL .
|
-
- HY-173270
-
|
|
Bacterial
|
Infection
|
|
Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC50 of PAO1: 0.40 μM and IC50 of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin (HY-B0441) and Ciprofloxacin (HY-B0356) in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections .
|
-
- HY-162256
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 184 (compound 4j) is a fungal inhibitor that is toxic to the plant pathogenic fungus Sclerotinia sclerotiorum. Antibacterial agent 184 can effectively inhibit Sclerotinia sclerotiorum (IR>97%) .
|
-
- HY-152175
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation .
|
-
- HY-173239
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 274 (Compound 18b) is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 μg/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections .
|
-
- HY-174389
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 283 (Compound 13) is an antimicrobial agent. Antibacterial agent 283 is active against both Gram-positive and Gram-negative bacteria, with potency comparable to the antibiotic Ampicillin (HY-B0522) .
|
-
- HY-163508
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 210 (compound A9), an amide derivative, is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR .
|
-
- HY-168729
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model .
|
-
- HY-W074648
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 18 is a multi-arm AIE molecule extracted from patent CN110123801A, compound 23. Antibacterial agent 18 can be used for resisting Gram-positive and Gram-negative bacteria. Antibacterial agent 18 can be conjugated in the cell wall of rigid arm configuration insertion bacterium, and block cell wall turns sugar and turns peptide process, to inhibit or kill bacterium .
|
-
- HY-121661
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 201 (Compound 3) is an antibacterial agent through disruption of membrane integrity. Antibacterial agent 201 inhibits proliferation of Staphylococcus aureus strain RN4220, methacillin-resistane S. aureus, Pseudomonas aeruginosa strain PA01 and Escherichia coli strain ANS1 with MIC99s of 2.0, 1, 8.1 and 2.2 μg/mL, respectively .
|
-
- HY-142075
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 134 (compound 1) is an diketopiperazine alkaloid with antimicrobial activity. Antibacterial agent 134 is the major metabolite in the culture of Hymeniacidon perleve associated bioactive bacterium Pseudomonas sp. NJ6-3-1 .
|
-
- HY-158242
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 212 (Compound 162) is an antibacterial agent with oral activity and good pharmacokinetic properties, having a MIC of 4 μg/mL against Pseudomonas aeruginosa T-2022-D2-048 .
|
-
- HY-161404
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .
|
-
- HY-163142
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 172 (Compound 6a) is a <,i>Clostridioides difficile (Cd) SpoVD inhibitor (IC50=89 nM) that effectively inhibits sporulation of Clostridioides difficile. Antibacterial agent 172 can be used in the study of bacterial infections .
|
-
- HY-155491
-
|
|
Bacterial
|
Cancer
|
|
Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobacterium nucleatum inhibitor with a MIC50 of 1 μg/mL. Antibacterial agent 166 effectively attenuates the migratory ability of MC-38 cells induced by Fusobacterium nucleatum. Antibacterial agent 166 is a promising anti-F. nucleatum lead compound and can be used for colorectal cancer (CRC) research .
|
-
- HY-163517
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 211 (compound k15) has bactericidal activity against clinically isolated MRSA and VRE (MICs = 0.25–1.00 μg/mL). Antibacterial agent 211 avoids resistance by damaging biofilm and targeting cell membranes .
|
-
- HY-162521
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml .
|
-
- HY-144618
-
-
- HY-153576
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 143 (Compound 5a) is an antibacterial agent with MICs of 25, 25, 50 and 50 μg/mL against B. subtilis ATCC6633, S. aureus ATCC6538, P. aeruginosa ATCC13525 and E. coli ATCC35218, respectively .
|
-
- HY-162329
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MICS.aureus=0.021 mg/mL; MICP.acnes=0.030 mg/mL), Gram-negative bacterium (MICE.coli=0.092 mg/mL; MICC.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL) .
|
-
- HY-161413
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
Antibacterial agent 204 (Compd P2-56-3) possesses potentiated Rifampin (RIF) activity against Acinetobacter baumannii and Klebsiella pneumoniae. Antibacterial agent 204 (Compd P2-56-3) disrupts the outer membrane of A. baumannii. T .
|
-
- HY-163631
-
|
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL .
|
-
- HY-163292
-
|
|
Bacterial
Parasite
|
Infection
|
|
Antibacterial agent 180 (15g), an appropriate substrate for the type I nitro reductases (TcNTR I), is a promising antitrypanosomatid agent. Antibacterial agent 180 (15g) shows nonmutagenic potential against Salmonella typhimurium strains (TA98, TA100, and TA102) .
|
-
- HY-169187
-
|
|
Bacterial
|
Cancer
|
|
Antibacterial agent 247 (compund 30b) is a bacterial antagonist that significantly inhibits the formation of Pseudomonas aeruginosa biofilm (IC50=5.8 μM) and multiple virulence phenotypes, and enhances its interaction with Tob Antibacterial activity of combined therapy with ampicillin and polymyxin B .
|
-
- HY-151944
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL) .
|
-
- HY-152250
-
|
|
Cytochrome P450
Bacterial
|
Infection
|
|
Antibacterial agent 132 has anticandidal effects against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg/mL and 62.50 μg/mL, respectively. Antibacterial agent 132 inhibits aromatase enzyme with an IC50 of 0.047μM .
|
-
- HY-168955
-
-
- HY-149610
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains) .
|
-
- HY-139887
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 63, a conjugate of aztreonam to a siderophore mimetic, shows activity against gram-negative bacteria.
|
-
- HY-152252
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antibacterial agent 133 (4l) is an antimicrobial agent that has shown anti-Candida activity, particularly through LMD enzyme inhibition. Antibacterial agent 133 shows MIC90 values of 1.95 μg/mL against Candida albicans ATCC 24433, Candida smoothis ATCC 90030 and Candida subtilis ATCC 22019 .
|
-
- HY-132918
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 30 demonstrates excellent in vitro activity against Xoo with EC50 value of 1.9 μg/mL.
|
-
- HY-161752
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 224 is a potent and selective synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system .
|
-
- HY-W838632
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 266 (Compound C5) is a plant pathogen inhibitor that disrupts bacterial integrity, with EC50 values of 24.1 μg/mL and 39.0 μg/mL against Xanthomonas oryzae pv oryzae (Xoo) and X. axonopodis pv citri (Xac), respectively. Antibacterial agent 266 can be used in the development of plant pathology and agricultural antimicrobial agents research .
|
-
- HY-156282
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 158 (compound 6c), a Micrococcin analogue, and is effective against impetigo and C. difficile infection (CDI) .
|
-
- HY-162615
-
-
- HY-163716
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 222 ((R)-O30 (5)) is a antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-155096
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 149 (Compd 3j) is a laccase inhibitor with high fungicidal activity and can be used in the study of rice sheath blight .
|
-
- HY-173238
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS). Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus .
|
-
- HY-139863
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 62 is a novel redox cycling antituberculosis chemotype with potent bactericidal activity against growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria.
|
-
- HY-161802
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC50 for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessus ATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .
|
-
- HY-169338
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 253 (compound 7a) is a potent inhibitor of bacterial, with the MIC of 1.562 μg/mL for P. aeruginosa, S. aureus, L. monocytogenes, B. cereus, and S. typhi .
|
-
- HY-145326
-
|
|
Fungal
|
Others
|
|
Antibacterial agent 67 (IC50 = 0.03 μM) has a great enzyme-inhibiting activity increase toward succinate dehydrogenase in comparison with fluxapyroxad (IC50 = 4.40 μM).
|
-
- HY-151880
-
|
|
DNA/RNA Synthesis
|
Infection
|
|
Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS) .
|
-
- HY-168853
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 261 (compound 43) is a potent inhibitor of peptidomimetic peptide deformylase (PDF), with IC50 of 2.5 and 10.6 nM for S. aureus and E. coli, respectively .
|
-
- HY-163528
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 213 (compound Thy3d) shows potent antimicrobial activity by disrupting the integrity of
the membrane of bacterial, with the MIC of 0.5 μg/ml for Staphylococcus aureus (MRSA) .
|
-
- HY-163397
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
|
-
- HY-145325
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 66 (Compound 6q), a trifluoromethylpyridine 1,3,4-oxadiazole derivative, shows activity against Xanthomonas oryzae pv. oryzae (Xoo) with an EC50 value of 7.2 μg/mL .
|
-
- HY-173192
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 272 (Compound Z22) is a potential antimicrobial agent targeting DNA and the DNA-topoisomerase II (DNA-Topo II) complex, exhibiting MIC values of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853, demonstrating potent antibacterial activity. This compound functions by intercalating with DNA base pairs to disrupt normal bacterial DNA function, making it suitable for research on bacterial infectious diseases .
|
-
- HY-146503
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 86 (Compound A11) is the most active and displays bacteriostatic activities against methicillin-resistant S. aureus, with MIC values as low as 0.00191 μg/mL, which is 162 and 32 times lower than that of the marketed antibiotics tiamulin and retapamulin, respectively .
|
-
- HY-159809
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 249 demonstrates broad-spectrum antimicrobial properties, effectively inhibiting the growth of Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus, while also exhibiting anti-inflammatory activity in vitro, making it a potential candidate for treating bacterial infections.
|
-
- HY-W756467
-
|
1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid-13C,d3
|
Isotope-Labeled Compounds
Bacterial
Drug Intermediate
|
Infection
|
|
Antibacterial agent 265- 13C,d3 (1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid- 13C,d3) is the deuterium labeled and 13C-labeled Antibacterial agent 265 (HY-W018629). Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans .
|
-
- HY-144387
-
|
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
ient S. Tm and hyperpermeable Escherichia coli. The potencies against WT strains of E. coli, Acinetobacter baumannii, and Burkholderia cenocepacia are also improved considerably (up to >128-fold) with the outer-membrane permeabi
|
-
- HY-144252
-
|
|
ROS Kinase
|
Infection
|
|
Antimicrobial agent 69 is a novel structural antimicrobial regulator and has been used to fight deadly multidrug-resistant bacterial infections, and its MICs value is 2.978 μM.
|
-
- HY-146373
-
|
|
Bacterial
|
Infection
|
|
The minimum inhibitory concentration (MIC) of a new 2- (quinoline-4-methoxy) acetamide antituberculotic agent against the reference strain of Mycobacterium tuberculosis H37Rv was as low as 0.3 μ M. It also inhibited the growth of Mycobacterium tuberculosis in the macrophage model of tuberculosis infection.
|
-
- HY-W083373
-
|
antibacterial agent 65
|
Bacterial
|
Infection
|
|
(E)-3,4-Dimethoxychalcone is an isoform of 3,4-Dimethoxychalcone (HY-W083373A), a potential antimicrobial and antioxidant agent.
|
-
- HY-N10296
-
|
|
Bacterial
|
Infection
|
|
Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity .
|
-
- HY-105838
-
|
Sulfametomidine; Telemid; Methofadin
|
Bacterial
|
Infection
|
|
Sulfamethomidine is an antibacterial agent .
|
-
- HY-123315
-
|
Methylsulfadiazin
|
Bacterial
|
Infection
|
|
Sulfaperin (Methylsulfadiazin) is an antibacterial agent .
|
-
- HY-N3528
-
|
|
Bacterial
|
Infection
|
|
Camaric acid can be isolated from the root of Lantana montevidensis and has antibacterial activity .
|
-
- HY-N7515A
-
-
- HY-116519
-
|
|
Bacterial
|
Infection
|
|
LY173013 is an antibacterial agent with a broad spectrum antibacterial activity. LY173013 binds to PBP 3 of E.coli and can be utilized in antibacterial research .
|
-
- HY-W067673
-
|
|
Bacterial
|
Infection
|
|
4-Methoxycoumarin (Compound 6) shows antibacterial activity of against R. solanacearum .
|
-
- HY-P5721
-
|
|
Bacterial
|
Infection
|
|
Apidaecin IA is an antibacterial peptide that can be found in honeybees .
|
-
- HY-103658
-
|
Miramistin
|
Bacterial
|
Infection
|
|
Myramistin (Miramistin) is an antibacterial agent targeting bacterial cell membrane. Myramistin can bind to the negatively charged surface of bacteria through its cationic properties, disrupt the integrity of the bacterial cell membrane, inhibit bacterial metabolism and growth, and induce cell death, thus exerting antibacterial activity .
|
-
- HY-N2208A
-
-
- HY-N14164
-
|
|
Bacterial
|
Infection
|
|
Echinoserine is an analog of Echinomycin (HY-106101) with antibacterial activity .
|
-
- HY-P10200
-
|
|
Bacterial
|
Infection
|
|
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
|
-
- HY-B1354
-
|
SM-1652 free acid; Wy-44635 free acid
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
|
|
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase .
|
-
- HY-W097570
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamonomethoxine sodium is a long acting sulfonamide?antibacterial?agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .
|
-
- HY-151221
-
|
|
Bacterial
|
Infection
|
|
CID 697851 is an AddAB and RecBCD inhibitor, with IC50s of 13 and 33 nM. CID 697851 can be used for antibacterial research .
|
-
- HY-164643
-
|
|
Antibiotic
Fungal
|
Infection
|
|
Antifungal agent 113 (compound 9a) is a potent antifungal and antibacterial agent. Antifungal agent 113 shows good antibacterial activity against S. aureus and methicillin-resistant S. aureus .
|
-
- HY-130839
-
|
|
Bacterial
|
Infection
|
|
LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity .
|
-
- HY-B0212S
-
-
- HY-122918
-
|
|
Bacterial
|
Infection
|
|
Moracin T can be isolated from the bark of mulberry trees and has antibacterial activity.
|
-
- HY-B1071
-
-
- HY-115859
-
-
- HY-B1071A
-
|
Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium
|
Antibiotic
Bacterial
Autophagy
Parasite
Apoptosis
|
Infection
Cancer
|
|
Lasalocid sodium (Lasalocid sodium-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid sodium exhibits antitumor activity. Lasalocid sodium is orally active .
|
-
- HY-153429
-
|
|
Bacterial
|
Infection
|
|
WU-FA-01, a hydrogenated derivative of WU-FA-00, is an antibacterial agent that exhibits high levels of antibacterial activity against Gram-positive strains and also has some anti-inflammatory activity .
|
-
- HY-W588257
-
-
- HY-21745
-
|
|
Bacterial
|
Infection
|
|
MurA-IN-4 has antibacterial activity and is a MurA inhibitor that inhibits bacterial cell wall synthesis .
|
-
- HY-128509
-
|
Dioxydine
|
Bacterial
|
Infection
|
|
Dioxidine is an antibacterial agent. Dioxidine inhibits the growth of bacteria Dioxidine can be usde for suppurative infections study .
|
-
- HY-W050151
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent that defends the emerging antibacterial resistance, which is found in marine Streptomyces sp. VITVSK1. 2,5-Di-tert-butyl-1,4-benzoquinone is also a potent inhibitor of RNA polymerase .
|
-
- HY-116587
-
|
Cloflucarban
|
Bacterial
|
Infection
|
|
Halocarban is a chemical with antibacterial properties sometimes used in deodorant and soap .
|
-
- HY-169697
-
|
|
Bacterial
|
Infection
|
|
Thiocillin is a thiopeptide class of RiPPs and anti-bacterial agent. Thiocillin targets the bacterial 50S ribosome. Thiocillin exhibits potent antibacterial activity against a number of agent resistant pathogens .
|
-
- HY-105113
-
-
- HY-163197
-
|
|
Bacterial
|
Infection
|
|
JSF-2827 is a benzothiophene with antibacterial activity against Enterococcus faecium .
|
-
- HY-N12149
-
|
|
Bacterial
|
Infection
|
|
Axinysone B can be isolated from Laurencia similis. Axinysone B has antibacterial activity against Staphylococcus sp. .
|
-
- HY-135889
-
|
|
Bacterial
|
Infection
|
|
CPFX2090 is a cephalosporin antibacterial compound extracted from patent WO2013052568A1, Compound Example 16g .
|
-
- HY-N10050
-
|
14-Hydroxycoreoside A
|
Bacterial
|
Infection
|
|
Coreoside B (14-Hydroxycoreoside A) can be isolated from Coreopsis tinctoria Nutt. and has weak antibacterial activity .
|
-
- HY-N10302
-
-
- HY-P10874
-
|
|
Bacterial
|
Infection
|
|
SMR efflux inhibitor targets the small multidrug resistance (SMR) efflux pump, blocks the interaction of TM4-TM4, and exhibits board-spectrum antibacterial activity .
|
-
- HY-122983
-
-
- HY-112586
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs .
|
-
- HY-N13147
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Tetromycin C5 is an antibiotic, that exhibits board-spectrum antibacterial activity against gram-positive bacteria and their drug-resistant bacteria .
|
-
- HY-111988
-
|
Wy 20788
|
Bacterial
|
Infection
|
|
Penamecillin (Wy 20788) an acetoxymethyl ester of Penicillin G (HY-N7139). Penamecillin is an orally active antibacterial agent .
|
-
- HY-B1071R
-
|
Lasalocid-A (Standard); Ionophore X-537A (Standard); Antibiotic X-537A (Standard)
|
Reference Standards
Bacterial
Autophagy
Antibiotic
Parasite
Apoptosis
|
Infection
Cancer
|
|
Lasalocid (Standard) is the analytical standard of Lasalocid. This product is intended for research and analytical applications. Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid exhibits antitumor activity. Lasalocid is orally active.
|
-
- HY-136954
-
|
|
Bacterial
|
Infection
|
|
LL-BM123γ2 is an antibacterial agent which is active against a variety of microorganisms. LL-BM123γ2 can be used for antibacterial research .
|
-
- HY-121021
-
|
|
Bacterial
|
Infection
|
BB-78485 is an LpxC metalloenzyme inhibitor with antibacterial activity. BB-78485 can inhibit LpxC with an IC50 value of 160 nM. BB-78485 can be used for the research of gram-negative selective antibacterials .
|
-
- HY-N0199
-
|
|
Bacterial
|
Infection
|
|
Albaspidin AA displays strong antibacterial activity against the vegetative form of Paenibacillus larvae (P. larvae) (MIC=220 μM) .
|
-
- HY-W097570R
-
|
|
Bacterial
Antibiotic
Reference Standards
|
Infection
|
|
Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .
|
-
- HY-115843
-
-
- HY-N6711A
-
-
- HY-118281
-
|
|
Bacterial
|
Infection
|
|
ATD-3169 is an antibacterial agent. ATD-3169 enhances endogenous ROS, including superoxide radicals, to inhibit Mycobacterium tuberculosis (Mtb) .
|
-
- HY-W060074
-
|
|
Endogenous Metabolite
Bacterial
Tyrosinase
PERK
|
Infection
Endocrinology
|
|
1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin .
|
-
- HY-N7111
-
|
Sultamicillin (tosilate)
|
Bacterial
Antibiotic
|
Infection
|
|
Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
- HY-123412
-
-
- HY-157729
-
|
|
Fungal
|
Others
|
|
1-Undecanoylglycerol is a monoacylglycerol with antibacterial activity, which can be used in food additives research .
|
-
- HY-123515
-
|
|
Bacterial
|
Infection
|
|
Clorobiocin is a MlaC protein inhibitor that could bind to the MlaC protein. Clorobiocin has antibacterial effects .
|
-
- HY-N7115
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sultamicillin is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
|
-
- HY-W267444
-
|
Amylparaben
|
Bacterial
|
Infection
|
|
Pentyl 4-hydroxybenzoate (Amylparaben) is a type of paraben compound commonly used as a preservative, it has antibacterial properties and is related to the inhibition of induced oxygen consumption .
|
-
- HY-N2612
-
|
Daurisoline-d4; Dau-d4; (-)-O-Methyldauricine
|
Fungal
Bacterial
|
Infection
Neurological Disease
|
|
O-Methyldauricine ((-)-O-Methyldauricine) is an alkaloid with benzylisoquinoline group, which can be separated from P. ophthalmicus. O-Methyldauricine has antibacterial activity .
|
-
- HY-148286
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex .
|
-
- HY-W016141
-
|
|
Bacterial
|
Infection
|
|
Methyl quinaldate (compound 3c) has antibacterial activity against Mycobacterium tuberculosis H37Rv with a MIC value of 2μg/mL .
|
-
- HY-N0827
-
-
- HY-126838
-
|
|
Antibiotic
|
Infection
|
|
Lavendofuseomycin is a macrolide pentaene antibiotic that can be utilized for antibacterial research .
|
-
- HY-119945A
-
-
- HY-N3798
-
|
|
Bacterial
|
Infection
|
|
Effusanin A is a natural product that can be found in Isodon rugosus. Effusanin A exhibits DNA-damaging and antibacterial activities .
|
-
- HY-119945
-
-
- HY-N3274
-
|
|
Bacterial
|
Infection
|
|
Methyl isocostate (compound 24）has antibacterial activity that can be isolated from Globba schomburgkii .
|
-
- HY-115127
-
|
|
Bacterial
|
Infection
|
|
3-Methylanisole is an intermediate in drug synthesis, which has antiseptic, antibacterial and protein stabilizing effects .
|
-
- HY-N1091
-
|
(+)-Vibsanin C
|
Bacterial
|
Infection
|
|
Vibsanin C is a subtype of vibsanin-type diterpenoids with cytotoxic and antibacterial activities .
|
-
- HY-P5641
-
|
|
Bacterial
|
Infection
|
|
Pleurocidin is an antibacterial peptide derived from skin secretions of Winter Flounder .
|
-
- HY-N7996
-
|
|
Bacterial
Fungal
|
Infection
|
|
Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity .
|
-
- HY-N14699
-
|
Ancillin free acid; 2-Biphenylyl penicillin free acid; SKF-12141 free acid
|
Penicillin-binding protein (PBP)
Bacterial
|
Infection
|
|
Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)-
resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci .
|
-
- HY-125163
-
|
8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin
|
Bacterial
Antibiotic
|
Infection
|
|
MM 47755 (8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin) is an antibiotic with antibacterial activity. MM 47755 can be isolated from Streptomyces .
|
-
- HY-N1307
-
|
|
Bacterial
|
Infection
|
|
Sideroxylonal A is an effective marine antifouling agent isolated from Eucalyptus jensenii. Sideroxylonal A has antibacterial activity against the Gram-positive bacteria Staphylococcus aureus and Bacilus subtilis .
|
-
- HY-156411
-
|
|
Bacterial
|
Cancer
|
|
NR-NO2 is a potential drug with targeted release and imaging-based guidance in antitumor research. NR-NO2 has an anti-bacterial effect .
|
-
- HY-N8151
-
|
|
Bacterial
|
Infection
|
|
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA) .
|
-
- HY-N7609
-
|
|
Bacterial
|
Infection
|
|
Kipukasin D is an natural nucleoside derived from Aspergillus versicolor with antibacterial activity .
|
-
- HY-N12906
-
-
- HY-138083
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Parvodicin C2 is a glycopeptide antibiotic that can be isolated from parvosata. Parvodicin C2 has antibacterial activity .
|
-
- HY-117065
-
|
|
Bacterial
|
Infection
|
|
MAC173979 is a inhibitor of PABA synthesis in E. coli. MAC173979 can be used for study of antibacterial drug development .
|
-
- HY-N3789
-
|
|
Bacterial
|
Infection
|
|
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).
|
-
- HY-P5057A
-
|
|
Fluorescent Dye
Bacterial
|
Infection
|
|
5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .
|
-
- HY-P5204
-
|
K1-EJ hybrid
|
Bacterial
|
Infection
|
|
Enterocin Hybrid 1 is a antibacterial agent, a antibacterial composition. Enterocin Hybrid 1 inhibits Vancomycin (HY-B0671)-resistant E. faecium, Staphylococcus haemoliticus .
|
-
- HY-N10281
-
|
|
Bacterial
|
Infection
|
|
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
|
-
- HY-30263
-
|
p-(Heptyloxy)phenol
|
Bacterial
|
Infection
|
|
4-Heptyloxyphenol (p-(heptyloxy)phenol) has antibacterial activity agaisnt P. gingivalis, S. artemidis, Str. sobrinus (MIC: 0.10, 0.21, 0.14 mM) .
|
-
- HY-W753904
-
|
|
Bacterial
|
Infection
|
|
Pradofloxacin, a third-generation fluoroquinolone antibacterial agent. Pradofloxacin can be used for the study of bacterial infections in the dog and cat, such as skin infections .
|
-
- HY-B0276
-
|
2-Ethylthioisonicotinamide
|
Bacterial
Antibiotic
|
Infection
|
|
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity .
|
-
- HY-161987
-
|
|
Bacterial
|
Infection
|
|
LpxH-IN-2 (compound 014) is a potent LpxH inhibitor. LpxH-IN-2 shows antibacterial activity for E. coli .
|
-
- HY-N3122
-
|
|
Bacterial
|
Infection
|
|
Pachyaximine A, an alkaloid isolated from the root of Sarcococca hookeriana, has some antibacterial activity .
|
-
- HY-A0241
-
|
RP54476
|
Bacterial
Antibiotic
|
Infection
|
|
Dalfopristin (RP54476) is a semisynthetic sulfone antibiotic. Dalfopristin alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci .
|
-
- HY-N8367
-
|
|
Others
|
Infection
|
|
Vitexolide D is a class of diterpenoid compounds. Vitexolide D was isolated from the natural Vitex vestita. Vitexolide D has antibacterial activity .
|
-
- HY-N10474
-
|
|
Bacterial
|
Others
|
|
Obtusalin is a triterpenoid found in R. dauricum for the first time and shows UV absorption at 210 nm. Obtusalin has some antibacterial activity .
|
-
- HY-N12524
-
|
|
Bacterial
|
Infection
Cancer
|
|
Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties .
|
-
- HY-135480
-
|
|
Bacterial
Fungal
|
Infection
|
|
Geninthiocin is a thiopeptide with antibacterial and antifungal activities. Geninthiocin is a tipA promoter .
|
-
- HY-126406
-
-
- HY-N1136
-
|
|
Bacterial
|
Infection
|
|
(+)-Totarol is a diterpenoid compound isolated from Podocarpus spp.. (+)-Totarol is a potent antioxidant and antibacterial agent .
|
-
- HY-123162A
-
|
Fortimicin A disulfate; KW-1070 disulfate
|
Antibiotic
Bacterial
|
Infection
|
|
Astromicin disulfate is a water-soluble aminoglycoside antibiotic that can be isolated from the genus Micromonospora. Astromicin disulfate exhibits broad spectrum antibacterial activity against gram positive and negative bacteria .
|
-
- HY-162595A
-
|
|
Bacterial
|
Infection
|
|
BDM88855 hydrochloride is an allosteric inhibitor for the homolog AcrB protein. BDM88855 hydrochloride can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli .
|
-
- HY-162595
-
|
|
Bacterial
|
Infection
|
|
BDM88855 is an allosteric inhibitor for the homolog AcrB protein. BDM88855 can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli .
|
-
- HY-77036R
-
|
Furazidine (Standard); Furazidin (Standard)
|
Reference Standards
Antibiotic
Bacterial
Carbonic Anhydrase
|
Infection
Cancer
|
Furagin (Standard) is the analytical standard of Furagin. This product is intended for research and analytical applications. Furagin (Furazidine) is an analogue of Nitrofurantoin (HY-A0090) and has antibacterial activity. Furagin also inhibits human carbonic anhydrases (Kis: 260 and 57 nM for hCA IX and XII, respectively) .
|
-
- HY-120658
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
(Rac)-LY193239 is a racemic modification of LY193239 (HY-120658A). LY193239 is a higher-lactam pyrazolidinone antibacterial agent .
|
-
- HY-158973
-
|
|
Bacterial
|
Infection
|
|
bCSE-IN-1 (Compound 3i) is an inhibitor of Bacterial Cystathionine γ-lyase. bCSE-IN-1 has antibacterial activity .
|
-
- HY-P10693
-
-
- HY-N3623
-
|
|
Bacterial
|
Infection
|
|
Corianin is a sesquiterpene lactone that can be isolated from the fruits of Coriaria ruscifolia. Corianin shows antibacterial activity against S. aureus and S. epidermis .
|
-
- HY-163367
-
|
|
Bacterial
|
Infection
|
|
MATE-IN-1 (Compound 31) is an inhibitor of MATE,with EC50 value of 1.8 μM. MATE-IN-1 has antibacterial activity .
|
-
- HY-N12954
-
|
|
Bacterial
|
Infection
|
|
(R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .
|
-
- HY-122975
-
|
Benzoyl metronidazole
|
Bacterial
Parasite
|
Infection
|
|
Metronidazole Benzoate, derives from a metronidazole and a benzoic acid, has a role as an antibacterial, antimicrobial, antiparasitic, and antitrichomonal agent .
|
-
- HY-119353
-
|
|
Bacterial
|
Infection
|
|
Repromicin is an antibacterial agent that inhibits P. multocida 56A006 with MIC value of 0.39 μg/mL .
|
-
- HY-116034
-
-
- HY-N6050
-
-
- HY-W590539
-
|
|
Bacterial
|
Infection
|
|
ω-azido-C6 Ceramide reduces the membrane potential, and exhibits antibacterial activity against Neisseria, with MIC of 2 µg/ml for N. meningitidis MC58 and N. gonorrhoeae FA1090 .
|
-
- HY-N10210
-
|
|
Bacterial
|
Infection
|
|
Saccharothrixin F is a highly oxygenated saccharothrixin, with antibacterial and anti-inflammatory activities .
|
-
- HY-129318
-
|
|
Bacterial
|
Infection
|
|
MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice .
|
-
- HY-N10282
-
-
- HY-105981
-
|
GR 50692; TA 5901
|
Antibiotic
Bacterial
|
Infection
|
|
Cefempidone (GR 50692) is a third-generation cephalosporin antibiotic. Cefempidone exerts antibacterial activity by inhibiting penicillin-binding proteins in bacterial cell wall synthesis .
|
-
- HY-145596
-
|
ZTS-00007928
|
Bacterial
|
Infection
|
|
Sirpefenicol (ZTS-00007928) is a phenicol antibacterial agent. Sirpefenicol can be used in bacterial infections in animals (extracted from patent WO2020068607A1) .
|
-
- HY-N12287
-
-
- HY-139597
-
-
- HY-B1915
-
|
Gentamicin C2b; Antibiotic XK-62-2; Sagamicin
|
Antibiotic
Bacterial
|
Infection
|
|
Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .
|
-
- HY-123635
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death .
|
-
- HY-122139
-
|
|
Bacterial
|
Infection
|
|
Desethylene Ciprofloxacin hydrochloride is a major metabolite of Ciprofloxacin (HY-B0356). Ciprofloxacin is an orally active topoisomerase IV inhibitor. Desethylene Ciprofloxacin hydrochloride has antibacterial activity .
|
-
- HY-112586R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sulfaethoxypyridazine (Standard) is the analytical standard of Sulfaethoxypyridazine. This product is intended for research and analytical applications. Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs .
|
-
- HY-129307
-
|
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Gilvocarcin V is an antibiotic with antibacterial activity and can be isolated from Actinomycete. Gilvocarcin V also has anti-tumor activity and can be used in cancer research .
|
-
- HY-149997
-
-
- HY-N3353
-
-
- HY-W055872
-
|
|
Antibiotic
|
Infection
|
|
Erythromycylamine is a macrolide antibiotic. Erythromycylamine has antibacterial activity against most Gram-positive cocci and M. catarrhalis .
|
-
- HY-155546
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
|
-
- HY-P5734
-
|
|
Bacterial
|
Infection
|
|
Bactenecin 5 is a bovine antibacterial peptide. Bactenecin 5 is active against Escherichia coli, Salmonella typhimurium, and Klebsiella pneumoniae. T, with MIC values of 12-25 μg/mL .
|
-
- HY-154862
-
|
|
Apoptosis
|
Infection
Cancer
|
|
Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS production to promote cancer cell apoptosis .
|
-
- HY-N14781
-
|
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
10-Decarbamoyloxy-9-dehydromitomycin B is a mitomycin. 10-Decarbamoyloxy-9-dehydromitomycin B has antibacterial and antitumor activity .
|
-
- HY-163042
-
|
|
Bacterial
|
Infection
|
|
HSGN-218 is an antibacterial agent with low Caco-2 permeability. HSGN-218 efficiently inhibits the growth of different C. difficile species with MIC values ranging from 0.007 μM to 0.07 μM.
|
-
- HY-N14736
-
|
|
Bacterial
|
Infection
|
|
Drosophilin is an antibacterial agent found in fungi, including Drosophilin A, B, C, and D. Drosophilin inhibits the growth of Gram-positive bacteria .
|
-
- HY-16943
-
-
- HY-N15368
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Pradimicinone I (Compound 10), a Pradimicin A (HY-132191) analog, is an antibiotic. Pradimicinone I is promising for research of antibacterial agents .
|
-
- HY-155333
-
|
|
Bacterial
|
Infection
|
|
Antibiofilm agent-1 is an antibacterial agent that inhibits growth of Gram-positive pathogens (WO2017011725A1; compound 17) .
|
-
- HY-N7111R
-
|
Sultamicillin (tosilate) (Standard)
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Reference Standards
Bacterial
Antibiotic
|
Infection
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|
Sultamicillin (tosylate) (Standard) is the analytical standard of Sultamicillin (tosylate). This product is intended for research and analytical applications. Sultamicillin tosylate is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
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-
- HY-W747311
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- HY-129435
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|
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Antibiotic
Bacterial
|
Infection
Cancer
|
|
Altromycin E is an antibiotic, that exhibits antibacterial against Streptococci and Staphylococci with MIC of 0.2-3.12 μg/mL. Altromycin E can be used in anti-tumor research .
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-
- HY-N7115R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sultamicillin (Standard) is the analytical standard of Sultamicillin. This product is intended for research and analytical applications. Sultamicillin is a broad-spectrum and orally active beta-lactamase inhibitor, an antibiotic with antibacterial activity .
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- HY-N11879
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Bacterial
Antibiotic
|
Others
|
|
6-C-Methylquercetin-3,4'-dimethyl etheris a flavonol derivative isolated from the leaves of Bauhinia thonningii Schum. 6-C-Methylquercetin-3,4'-dimethyl ether has antibacterial activity against Gram-negative multidrug-resistant bacteria and against methicillin-resistant Staphylococcus aureus (MRSA) strains .
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- HY-121909
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|
|
Bacterial
Antibiotic
|
Infection
|
|
Piperic acid is a natural antioxidant and antibacterial agent. Piperic acid can be used in food preservation and human health .
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-
- HY-P10228
-
|
|
Fungal
Bacterial
|
Infection
|
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
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-
- HY-Y0729
-
|
|
Tyrosinase
Bacterial
Fungal
|
Infection
|
|
4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth .
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-
- HY-12450
-
|
Lomondomycin
|
Antibiotic
Bacterial
|
Infection
|
|
Lomofungin is a novel antibiotic produced by Streptomyces lomondensis sp.N . Lomofungin can inhibit MBNL1-CUG RNA binding. Lomofungin has antibacterial activity .
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-
- HY-100622
-
|
|
Bacterial
|
Infection
|
|
Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine .
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-
- HY-171795
-
|
|
Bacterial
Fungal
|
Infection
|
|
Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections .
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-
- HY-123451
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|
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Bacterial
|
Infection
|
|
ACH-702 is a potent anti-tubercular agent. ACH-702 also shows broad-spectrum antibacterial activity .
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-
- HY-119881
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties .
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-
- HY-N14364
-
|
Flavipucin
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Flavipucine (Flavipucin), a glutarimide antibiotic, is found in the strain of Aspergillus flavipes F-2090/7. Flavipucine has antibacterial activity against B. subtilis. Flavipucine has antiprotozoal activity. Flavipucine has cytotoxic activity against several cancer cells .
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-
- HY-W115276
-
|
|
Bacterial
Fungal
|
Infection
|
|
Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis .
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-
- HY-162473
-
|
|
Bacterial
|
Infection
|
|
MLEB-1934 is a DNA replication inhibitor as a potent metergoline analog and can be used for antibacterial research .
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-
- HY-N2594
-
|
|
Bacterial
|
Infection
|
|
Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .
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-
- HY-B0875B
-
|
SCE-1365 sodium
|
Antibiotic
Bacterial
|
Infection
|
|
Cefmenoxime sodium is a new semisynthetic cephalosporin antibiotic. Cefmenoxime sodium has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria .
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-
- HY-148286R
-
|
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Gentamicin C1a (Standard) is the analytical standard of Gentamicin C1a. This product is intended for research and analytical applications. Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex .
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-
- HY-131554
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections .
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-
- HY-P5692
-
|
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Bacterial
|
Infection
|
|
Maximin 77 is an antimicrobial peptide. Maximin 77 has antibacterial activity against S. aureus (MIC: 18.8 μg/mL). Maximin 77 has hemolytic activities against human red cells .
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-
- HY-N15518
-
|
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PDHK
Bacterial
|
Infection
|
|
Pipcroside C is found in P. crocatum Ruiz & Pav. Pipcroside C is a PDH inhibitor (IC50: 80.25 µM). Pipcroside C has antibacterial activity and is used in the study of oral infections .
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-
- HY-P5689
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|
|
Bacterial
|
Infection
|
|
Maximin 42 is an antimicrobial peptide. Maximin 42 has antibacterial activity against S. aureus (MIC: 37.5 μg/mL). Maximin 42 has hemolytic activities against human red cells .
|
-
- HY-N8395
-
|
Tunicamycin A
|
Bacterial
|
Infection
|
|
Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35?μM. Tunicamycin V has antibacterial activties .
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-
- HY-P5691
-
|
|
Bacterial
|
Infection
Cancer
|
|
P1 is a broad-spectrum antimicrobial peptide. P1 shows antibacterial activity against Gram-positive and Gram-negative bacteria,such as B. anthracis spores and Carbapenem-resistant A. baumannii and K. pneumoniae .
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-
- HY-W854341
-
|
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Antibiotic
Bacterial
|
Infection
|
|
Chitotriose is a chitooligosaccharide that can be isolated from crab shell chitosan. Chitotriose has antibacterial effect against salmonella .
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-
- HY-120315
-
|
|
Bacterial
|
Infection
|
|
Nyssoside, a ellagic acid derivative, has significant antioxidant activity and shows antibacterial activity against different pathogenic bacteria .
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-
- HY-N8091
-
|
|
Bacterial
|
Infection
Cancer
|
|
Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities .
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-
- HY-N7322
-
|
|
Bacterial
|
Infection
|
|
Swietemahalactone is a natural compound isolated from Swietenia mahagoni. Swietemahalactone exhibits antibacterial activity aganist E. coli .
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-
- HY-129166
-
|
|
Bacterial
|
Infection
|
|
UCM53, a FtsZ inhibitor, is an antibacterial agent. UCM53 can inhibit the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis
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-
- HY-W072009
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|
|
Bacterial
|
Infection
|
|
5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-dihydroxycoumarin displays antibacterial characteristics with an MIC value in the range of 1000 mg/mL to >1000 mg/mL. Some 5,7-dihydroxycoumarin derivatives have antioxidant properties .
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-
- HY-N15517
-
|
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PDHK
Bacterial
|
Infection
|
|
Pipcroside B is found in P. crocatum Ruiz & Pav. Pipcroside B is a PDH inhibitor (IC50: 99.82 µM). Pipcroside B has antibacterial activity and is used in the study of oral infections .
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-
- HY-101048
-
|
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Bacterial
|
Infection
Metabolic Disease
|
|
Synthalin A sulfate is a biguanylated diamine with antibacterial and hypoglycemic properties. Synthalin A sulfate against S. aureus with a MIC of 64 μg/mL .
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-
- HY-131557
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|
|
Antibiotic
Bacterial
|
Infection
|
|
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .
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-
- HY-E70250
-
|
Cryptotackieine
|
Parasite
Bacterial
Fungal
|
Infection
|
|
Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity .
|
-
- HY-N12267A
-
|
(E)-N,N′-Diferuloylputrescine
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Terrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects .
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-
- HY-N2980
-
|
Cabraleone
|
Bacterial
|
Infection
|
|
Ocotillone ((24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoids that can be isolated from the fruits of Dysoxylum richii. Ocotillone has antibacterial activities against P. aeruginosa and S. typhimurium without hemolytic activity .
|
-
- HY-P5687
-
|
|
Bacterial
|
Infection
|
|
Im5, an antimicrobial peptide, has antibacterial (MIC: 10, 2.5-5, 0.5-1 μM for E. coli, S. aureus, B. subtilis respectively) and hemolytic activity (EC50: 28 μM) .
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-
- HY-121785
-
|
|
Bacterial
|
Infection
Cancer
|
|
10-Thiofolic acid is a potent antibacterial and antitumor agent. 10-Thiofolic acid inhibits the growth of Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469). 10-Thiofolic acid has the potential for the research of leukemia .
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-
- HY-169176
-
|
|
Bacterial
|
Infection
|
|
LpxC-IN-15 ((S)-13j) is a potent LpxC inhibitor with Ki values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity .
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-
- HY-169416
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Anti-MRSA agent 21 (Compound 27) has antibacterial activity against MRSA, with an MIC of 1 μM. Anti-MRSA agent 21 can damage bacterial cell membranes and increase reactive oxygen species .
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-
- HY-N11422
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis .
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-
- HY-B2072A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity .
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-
- HY-B2072
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity .
|
-
- HY-N3139
-
|
|
Bacterial
|
Infection
|
|
Ombuin, isolated from Zanthoxylum armatum, displays broad spectrum antibacterial effect with MIC ranges from 125 to 500 μg/mL .
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-
- HY-N15516
-
|
|
Bacterial
|
Infection
|
|
Pipcroside A is found in P. crocatum Ruiz & Pav. Pipcroside A has antibacterial activity and can be used in the study of oral infections .
|
-
- HY-B0875
-
|
SCE-1365 hydrochloride
|
Antibiotic
Bacterial
|
Infection
|
|
Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria .
|
-
- HY-B0875A
-
|
SCE-1365
|
Antibiotic
Bacterial
|
Infection
|
|
Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria .
|
-
- HY-A0248
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .
|
-
- HY-113784
-
|
Isoxyl
|
Antibiotic
Bacterial
|
Infection
|
|
Thiocarlide is a potent antibacterial agent. Thiocarlide inhibits Mycobacterium tuberculosis H37Rv, Mycobacterium bovisBCG, Mycobacterium avium, and Mycobacterium aurum A+ with MICs of 2.5, 0.5, 2.0 and 2.0 μg/mL, respectively .
|
-
- HY-19748
-
|
|
Bacterial
|
Infection
|
|
LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity .
|
-
- HY-N12851
-
|
(E)-4-Oxo-2-hexenal
|
Bacterial
|
Infection
|
|
4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by the peroxidation of omega-3 fats. 4-OHE has antibacterial activity .
|
-
- HY-N8406
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-100385
-
|
Cyclo(L-Pro-L-Trp)
|
PI3K
Bacterial
|
Infection
|
|
Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM .
|
-
- HY-B0529
-
|
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Azlocillin, an antibiotic, is a semisynthetic penicillin, and has broad-spectrum antibacterial activity. Azlocillin is active against drug-tolerant B. burgdorferi sensu stricto JLB31 infection .
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-
- HY-152117
-
|
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Acetyl-CoA Carboxylase
Bacterial
|
Infection
|
|
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity .
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-
- HY-W049970
-
|
|
Bacterial
|
Infection
|
|
Carvacrol methyl ether is a carvacrol derivative isolated from plant volatile oil. Carvacrol methyl ether exhibits antibacterial activity. Carvacrol methyl ether is a proton acceptor .
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-
- HY-173254
-
|
|
Bacterial
|
Infection
|
|
MurA-IN-6 (Compound L16) is a selective MurA inhibitor with an IC50 value of 26.63 μM. MurA-IN-6 exerts antibacterial activity by blocking the activity of MurA, which is crucial in bacterial cell wall synthesis .
|
-
- HY-W777979
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|
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Cytochrome P450
Bacterial
|
Infection
|
|
Frutinone A is a CYP1A2 inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant .
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-
- HY-Y0055
-
-
- HY-N7985
-
|
|
Parasite
Bacterial
|
Infection
Cancer
|
|
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .
|
-
- HY-16764
-
|
JNJ-Q2
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial agent being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia with oral activity. Avarofloxacin (JNJ-Q2) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value. Avarofloxacin (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections .
|
-
- HY-163486
-
|
|
Bacterial
|
Infection
|
|
Antituberculosis agent-10 (Compound 9) has excellent antibacterial activity against Mycobacterium tuberculosis (MIC = 0.3 μM). Antituberculosis agent-10 inhibits protein synthesis by targeting the 50S ribosomal subunit of the bacterium, thus exerting its antibacterial effect. Antituberculosis agent-10 is orally active .
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-
- HY-N8336
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
|
IT-143A is an antibiotic, that exhibits antibacterial and antifungal activity against Micrococcus luteus and Aspergillus fumigatus with MIC of 6.25-25 μg/mL. IT-143A inhibits growth of cancer cell KB with an IC50 of 0.36 ng/mL .
|
-
- HY-N7252
-
|
|
Bacterial
|
Infection
|
|
Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .
|
-
- HY-156014
-
|
|
DNA/RNA Synthesis
|
Infection
|
|
qsl-304 is a DNA gyrase B inhibitor. qsl-304 is an antibacterial agent, with an IC50 of 31.23 mg/mL against the Staphylococcus aureus sa-P2003 .
|
-
- HY-P5548
-
|
|
Bacterial
|
Infection
Cancer
|
|
CaLL is an antimicrobial peptide. CaLL has antibacterial activity against B. anthracis, B. anthracis (vegetative), and B. cepacia (MIC: 7.8, 31.3, 31.3 μg/mL) .
|
-
- HY-N15138
-
|
|
Glycosidase
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC50 of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .
|
-
- HY-138216
-
|
|
Bacterial
|
Infection
|
|
Despropylene gatifloxacin is a metabolism of AM-1155 (HY-10581). AM-1155 has potent antibacterial activity and favorable pharmacokinetics .
|
-
- HY-N0709
-
-
- HY-P5696
-
|
|
Bacterial
Parasite
Fungal
|
Infection
|
|
Xenopsin precursor fragment is an antimicrobial peptide, and has antibacterial/antifungal (10-500 μg/mL) and anti-protozoal (MIC: 2-20 μg/mL) activity .
|
-
- HY-162839
-
|
|
Bacterial
|
Infection
|
|
Cerastecin D (compound 1) is an antibacterial agent. Cerastecin D shows inhibition on Acinetobacter baumannii ATCC19606 with MITC95 values of 165 nM .
|
-
- HY-N6078
-
|
|
Bacterial
|
Infection
|
|
Thalrugosaminine is a benzylisoquinoline alkaloid isolated from the roots of Thalictrum minus. Thalrugosaminine shows good antibacterial activity with MIC values of 64-128 µg/ml .
|
-
- HY-122356
-
|
|
Bacterial
|
Cancer
|
|
Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities .
|
-
- HY-122356A
-
|
|
Bacterial
|
Cancer
|
|
Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities .
|
-
- HY-P5572
-
-
- HY-114816
-
|
C4-HSL; N-Butyryl-L-homoserine lactone
|
ADC Linker
Bacterial
|
Infection
Inflammation/Immunology
|
|
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
|
-
- HY-169521
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-16 (Compound 9) is the inhibitor for DNA gyrase with an IC50 of 1.609 μM. DNA Gyrase-IN-16 exhibits antibacterial activity, inhibits S. aureus and MRSA with MIC of 3.125 μM and 3.125 μM .
|
-
- HY-P5682
-
|
|
Bacterial
|
Infection
|
|
Maximin 41 is an antimicrobial peptide. Maximin 41 has antibacterial activity against S. aureus (MIC: 75 μg/mL). Maximin 41 has hemolytic activities against human red cells .
|
-
- HY-156456
-
|
|
Bacterial
|
Infection
|
|
Elastase LasB-IN-1 (Compound 4b) has antibacterial activity. Elastase LasB-IN-1 (Compound 4b) is a selective elastase LasB inhibitor with an IC50 value of 76 nM .
|
-
- HY-125685
-
|
|
Bacterial
Fungal
|
Cancer
|
|
Germacrene D is isolated from Solidago canadensis. Germacrene D has antibacterial and antifungal activities and can be used as an adjuvant agent in the application of aminoglycosides and azoles .
|
-
- HY-153695
-
|
|
Drug Metabolite
Bacterial
|
Infection
|
|
TXA707, the active metabolite of TXA-709, is an FtsZ inhibitor with antibacterial activity. TXA707 is promising for research of S. aureus infections .
|
-
- HY-W110662
-
|
|
Bacterial
|
Infection
|
|
Transtorine is a quinoline alkaloid, found from Ephedra transitoria, with antibacterial activity .
|
-
- HY-N3192
-
|
|
Bacterial
|
Infection
|
|
Nervogenic acid is an aromatic compound that can be isolated from Piper elongatum VAHL. Nervogenic acid has antibacterial activities and antioxidative effects .
|
-
- HY-N8935
-
|
|
Bacterial
Fungal
|
Infection
|
|
Eucamalduside A can be isolated from the leaves of Eucalyptus camaldulensis. Eucalyptus camaldulensis has antibacterial and antifungal activity .
|
-
- HY-122139R
-
|
|
Bacterial
Reference Standards
|
Infection
|
|
Desethylene Ciprofloxacin (hydrochloride) (Standard) is the analytical standard of Desethylene Ciprofloxacin (hydrochloride). This product is intended for research and analytical applications. Desethylene Ciprofloxacin hydrochloride is a major metabolite of Ciprofloxacin (HY-B0356). Ciprofloxacin is an orally active topoisomerase IV inhibitor. Desethylene Ciprofloxacin hydrochloride has antibacterial activity .
|
-
- HY-P5690
-
|
|
Bacterial
|
Infection
|
|
Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .
|
-
- HY-N1096
-
|
|
Parasite
Bacterial
|
Infection
|
|
Veratraldehyde is an orally active aromatic compound and antibacterial agent. Veratraldehyde can be isolated from essential oils of plants such as peppermint and ginger. Veratraldehyde targets the PilY1 protein. Veratraldehyde has antibacterial activity against Pseudomonas aeruginosa. Veratraldehyde has a repellent effect against mosquitoes and ticks. Veratraldehyde can be used as a flavoring agent .
|
-
- HY-B1852
-
|
|
Bacterial
Fungal
|
Infection
|
|
Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .
|
-
- HY-P5701
-
|
|
Bacterial
Fungal
|
Infection
|
|
EP2 is an antimicrobial peptide. EP2 has antibacterial and antifungal activities. EP2 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 11.4 μg/mL .
|
-
- HY-N9735
-
|
|
Bacterial
|
Infection
|
|
8-Hydroxy-9,10-diisobutyryloxythymol is a natural monoterpenoid with antibacterial properties. 8-Hydroxy-9,10-diisobutyryloxythymol against S. aureus, S. flexneri, and S. paratyphi-B with MIC values of 6.25 μg/mL .
|
-
- HY-B1008
-
-
- HY-P1926
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
A-54556A (ADEP 1) is an acyldepsipeptide (ADEP) antibiotic. A-54556A shows antibacterial activity against a broad range of Gram-positive bacteria .
|
-
- HY-136306
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A .
|
-
- HY-108569
-
|
|
Antibiotic
Bacterial
PPAR
|
Infection
|
|
nTZDpa is an antibiotic. nTZDpa is a PPARG partial agonist. nTZDpa has antibacterial activity. nTZDpa is effective against growing and persistent Staphylococcus aureus by lipid bilayer disruption .
|
-
- HY-B1915R
-
|
Gentamicin C2b (Standard); Antibiotic XK-62-2 (Standard); Sagamicin (Standard)
|
Antibiotic
Bacterial
|
Infection
|
|
Micronomicin (Standard) is the analytical standard of Micronomicin. This product is intended for research and analytical applications. Micronomicin (Gentamicin C2b) is an aminoglycoside antibiotic, with antibacterial and bactericidal activities .
|
-
- HY-N14092
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Chuangxinmycin is an antibiotic that can be isolated from Actinoplanes tsinanensis CPCC 200056. Chuangxinmycin exhibits both in vitro and in vivo antibacterial activities and can be utilized in infection research .
|
-
- HY-N5009
-
|
|
Bacterial
|
Infection
|
|
Thermopsine is a quinolizidine alkaloid isolated from the fruits and pods and stem bark of Sophora velutina subsp. Thermopsine has antibacterial activity .
|
-
- HY-163887
-
|
|
Bacterial
|
Infection
|
|
PBZ1038 is a highly effective inhibitor of Gram-negative chaperone proteins, achieving its antibacterial effect by inhibiting GroES/GroEL .
|
-
- HY-N3199
-
|
|
Bacterial
|
Infection
|
|
Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer .
|
-
- HY-149857
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .
|
-
- HY-157046
-
|
|
Bacterial
ATP Synthase
|
Infection
|
|
ATP Synthesis-IN-2 (Compound 5) is an antibacterial compound. ATP Synthesis-IN-2 is a potent ATP synthesis activity inhibitor with IC50 against Pseudomonas aeruginosa (PA) Value of 0.7 μg/mL .
|
-
- HY-124431
-
|
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Kikumycin A is an antibiotic, which can be generated from Streptomyces. Kikumycin A exhibits antibacterial activity against Gram-positive and Gram-negative bacteria. Kikumycin A exhibits antitrichomonal activity, with MIC of 25 μg/mL for Trichomonas foetus .
|
-
- HY-146263
-
|
|
Bacterial
|
Infection
|
|
ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities .
|
-
- HY-P5685
-
|
|
Bacterial
|
Infection
|
|
Maximin 49 is an antimicrobial peptide. Maximin 49 has antibacterial activity against S. aureus (MIC: 18.8 μg/mL). Maximin 49 has hemolytic activities against human and rabbit red cells .
|
-
- HY-170802
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 22 (Compound 5a) is a potent antibacterial agent against MRSA with a MIC value of 6 µg/mL. Anti-MRSA agent 22 exhibits high binding affinity (−11.19) to FabI .
|
-
- HY-P5603
-
|
BNBD-12
|
Bacterial
|
Infection
|
|
Bovine neutrophil beta-defensin 12 is an antimicrobial peptide derived from bovine neutrophils, which has antibacterial activity against Escherichia coli and Staphylococcus aureus .
|
-
- HY-N15182
-
|
|
Bacterial
Drug Derivative
|
Infection
|
|
4-Trehalosamine is a derivative of trehalose with weak antibacterial activity. 4-Trehalosamine shows no toxic effects when injected intravenously into mice at a dose of 625 mg/kg .
|
-
- HY-125654
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation .
|
-
- HY-P5695
-
|
|
Bacterial
|
Infection
|
|
GP-2B is an antimicrobial peptide. GP-2B shows antibacterial activity against Gram-positive strain (MIC: 8-128 μg/mL for S. aureus and Enterococcus faecalis) .
|
-
- HY-P5551
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
TLN-58 is an antimicrobial peptide. TLN-58 has antibacterial activity against S. aureus, S. epidermidis, and group A Streptococcus. TLN-58 also induces inflammatory cytokine mRNAs upregulation in normal human keratinocytes and NCL-SG3 cells .
|
-
- HY-W714002
-
|
|
HIV
Bacterial
|
Infection
|
|
Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus) .
|
-
- HY-151501
-
-
- HY-148077
-
|
|
Bacterial
Fungal
|
Infection
|
|
Phosphoglycolohydroxamic acid is a potent aldolase and triose-phosphate isomerase inhibitor. Phosphoglycolohydroxamic acid can be used in the research of antibacterial and antifungal area .
|
-
- HY-119606
-
|
NSC 66577
|
Bacterial
Fungal
|
Infection
|
|
Bacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth .
|
-
- HY-N3241
-
|
|
Bacterial
|
Infection
|
|
Mucrolidin is an eudesmane-type sesquiterpenoid isolated from aerial parts of homalomena occulta. Mucrolidin exhibits weak antibacterial activities when it compares to Rifampicin (HY-B0272) .
|
-
- HY-138181
-
|
MRX-I phosphoramidic acid
|
Drug Intermediate
|
Others
|
|
Contezolid phosphoramidic acid is an intermediate in the synthesis of proagents of antibacterial oxazolidinone agent MRX-I. Contezolid phosphoramidic acid is extracted from patent WO2015127316A1, Intermediate 3, Method I .
|
-
- HY-139597R
-
|
BRL 17421 disodium (Standard)
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
|
|
Temocillin (disodium) (Standard) is the analytical standard of Temocillin (disodium). This product is intended for research and analytical applications. Temocillin disodium, a 6-α-methoxy penicillin, possesses antibacterial activity .
|
-
- HY-B2170
-
|
|
Bacterial
|
Infection
|
|
Octenidine is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine can inhibit the expression of biofilm genes and destroy the formation of biofilms .
|
-
- HY-101411S
-
-
- HY-30235A
-
|
|
PGE synthase
Bacterial
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Benzydamine hydrochloride is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine hydrochloride can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells .
|
-
- HY-N3074
-
|
6,10,14-Trimethyl-2-pentadecanone
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research .
|
-
- HY-162358
-
|
|
Dihydrofolate reductase (DHFR)
Bacterial
|
Infection
|
|
DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL .
|
-
- HY-30235
-
|
|
PGE synthase
TNF Receptor
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Benzydamine is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells .
|
-
- HY-106668
-
|
Sch 21420
|
Antibiotic
Bacterial
|
Infection
|
|
Isepamicin (Sch 21420) is an aminoglycoside antibacterial. Isepamicin has better activity against strains producing type I 6'-acetyltransferase. Isepamicin’s antibacterial spectrum includes Enterobacteriaceae and staphylococci. Anaerobes, Neisseriaceae and streptococci are resistant. Isepamicin exhibits a strong concentration-dependent bactericidal effect, a long post-antibiotic effect (several hours) and induces adaptive resistance .
|
-
- HY-123354
-
|
|
Bacterial
|
Infection
|
|
SC 44914 is a quinoxaline compound with antibacterial effects. SC-44914 has activity against Campylobacter jejuni, C. coli, and Clostridium difficile .
|
-
- HY-N8300
-
|
|
Bacterial
|
Infection
|
|
Rupesin E is a natural product that can be isolated from Patrinia rupestris. Rupesin E has significant antibacterial activity against Escherichia coli .
|
-
- HY-134900
-
-
- HY-N2759
-
|
|
Bacterial
|
Infection
|
|
7-O-Isopentenyl-γ-fagarine is an alkaloid that can be isolated from Peltostigma guatemalense. 7-O-Isopentenyl-γ-fagarine has antibacterial and antimalarial activities in vitro .
|
-
- HY-B1825
-
|
|
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
|
Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-161457
-
-
- HY-151497
-
-
- HY-B1374
-
-
- HY-N15371
-
|
|
Others
|
Infection
Inflammation/Immunology
Cancer
|
|
Barbinine is a diterpene alkaloid with antibacterial, antioxidant, anti-inflammatory and antitumor activities. Barbinine is a phytotoxin found in several Delphinium species .
|
-
- HY-P5688
-
|
|
Bacterial
|
Infection
|
|
Maximin 68 is an antimicrobial peptide. Maximin 68 has antibacterial activity against C. albicans, S. aureus, E. coli, B. subtilis (MIC: 18.8, 9.4, 37.5, 9.4 μg/mL). Maximin 68 has hemolytic activities against human and rabbit red cells .
|
-
- HY-N1469
-
-
- HY-137956
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
Cancer
|
|
Previridicatumtoxin is a fungal metabolite with antibacterial and anticancer activities. Previridicatumtoxin can be extracted from P. aethiopicum and utilized in research related to cancer as well as infections .
|
-
- HY-P3884
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects .
|
-
- HY-N7057
-
|
Pelargonic acid
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
|
-
- HY-P10970
-
|
|
Bacterial
|
Infection
|
|
RT2 is a tryptophan-rich cationic amphipathic antibacterial peptide, with main targets including lipopolysaccharide (LPS) on the bacterial surface and intracellular DNA. RT2 binds to bacterial surface LPS, and interacts with cytoplasmic membrane phospholipids, enabling it to rapidly penetrate the bacterial cell membrane and enter the cell, and then bind to components such as DNA in the cytoplasmic membrane, thereby exerting antibacterial effects. RT2 is promising for research of acute and chronic infections caused by planktonic bacteria .
|
-
- HY-A0248R
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Polymyxin B (Sulfate) (Standard) is the analytical standard of Polymyxin B (Sulfate). This product is intended for research and analytical applications. Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .
|
-
- HY-130049
-
|
|
Bacterial
|
Infection
|
|
Lucidin ω-ethyl ether (compound 17) is an anthraquinone metabolite isolated from the root part of Prismatomeris filamentosa with some antibacterial activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-B2170B
-
|
|
Bacterial
|
Infection
|
|
Octenidine saccharin is a potent antibacterial agent, possessing activity against multidrug-resistant Gram-negative pathogens. Octenidine saccharin can inhibit the expression of biofilm genes and destroy the formation of biofilms .
|
-
- HY-119749
-
|
|
Bacterial
|
Infection
|
|
Diazaborine is an inhibitor for enoyl-acyl carrier protein (enoyl ACP) in an NAD+-dependent manner. Diazaborine exhibits antibacterial activity, MIC for E. coli and K. pneumoniae is 25 and 3.12 μg/mL .
|
-
- HY-139558
-
|
PD0184264; ATR-002
|
MEK
Influenza Virus
Bacterial
|
Infection
Cancer
|
|
Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities .
|
-
- HY-126046
-
|
|
ClpP
Bacterial
|
Infection
|
|
ACP1b is an activator for ClpP protease with Kd of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL .
|
-
- HY-14762
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Besifloxacin is a fluoroquinolone antimicrobial agent. Besifloxacin can inhibit cytokine production by monocytes. Besifloxacin has broad-spectrum antibacterial activity .
|
-
- HY-N3640
-
|
|
Bacterial
|
Infection
|
|
Crenatine is an antibacterial agent. Crenatine is more effective against Gram-positive than Gram-negative bacteria .
|
-
- HY-151502
-
-
- HY-B0875R
-
|
SCE-1365 hydrochloride (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Cefmenoxime (hydrochloride) (Standard) is the analytical standard of Cefmenoxime (hydrochloride). This product is intended for research and analytical applications. Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria .
|
-
- HY-N8337
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
IT-143B is an antibiotic, that exhibits antibacterial activity against Micrococcus luteus with MIC of 6.25μg/mL. IT-143B inhibits growth of cancer cell KB with an IC50 of 1.1 ng/mL .
|
-
- HY-125654C
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Olanexidine gluconate is an antibacterial agent. Olanexidine gluconate is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine gluconate is also an antiseptic. Olanexidine gluconate can be used in the research of infection and inflammation .
|
-
- HY-125654B
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Olanexidine hydrochloride semihydrate is an antibacterial agent. Olanexidine hydrochloride semihydrate is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine hydrochloride semihydrate is also an antiseptic. Olanexidine hydrochloride semihydrate can be used in the research of infection and inflammation .
|
-
- HY-N1654
-
|
|
Bacterial
|
Infection
|
|
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
|
-
- HY-W015879
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties .
|
-
- HY-B1085
-
|
Compound 64716
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
|
Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .
|
-
- HY-N13186
-
|
|
Bacterial
|
Infection
|
|
δ-(E)-Deoxy-amplexichromanol is a δ-tocotrienolic acid derivative with potent antibacterial activities, which is derivated from hydromethanolic extract of the cones of C. atlantica .
|
-
- HY-W037825
-
|
|
Bacterial
|
Infection
Cancer
|
|
Pterin is a Pteridine with antibacterial activity, which is found in C. croceus. Pterin reduces the proliferation and biofilm production in E. coli, P. aeruginosa, and S. mutans. Pterin is promising for research of cancers and infections .
|
-
- HY-121054
-
|
|
Bacterial
Parasite
|
Inflammation/Immunology
Cancer
|
|
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
|
-
- HY-B0529R
-
|
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Azlocillin (Standard) is the analytical standard of Azlocillin. This product is intended for research and analytical applications. Azlocillin, an antibiotic, is a semisynthetic penicillin, and has broad-spectrum antibacterial activity. Azlocillin is active against drug-tolerant B. burgdorferi sensu stricto JLB31 infection .
|
-
- HY-123711
-
|
|
Bacterial
|
Infection
|
|
PC170942, a PC58538 analogue, is a potent FtsZ protein inhibitor. PC170942 is a cell division inhibitor, and shows antibacterial activities .
|
-
- HY-128502
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Nifurtoinol is a nitrofuran-derivative antibiotic with antibacterial effects. Nifurtoinol can be used for the research of urinary tract infections .
|
-
- HY-158761
-
|
PAPB
|
Bacterial
|
Infection
|
Polyaminopropyl biguanide (PAPB), a propyl analogue of polyhexamethylene biguanide, is a broad spectrum, fast acting bactericide with antibacterial activity. Polyaminopropyl biguanide can be used as a preservative in cosmetic products .
|
-
- HY-P3459
-
|
|
Bacterial
|
Infection
|
|
Tet-213 is a antimicrobial peptide. Tet-213 has broad spectrum antibacterial activity. Tet-213 can promote infected wound repair .
|
-
- HY-125496
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
A201A is a aminoacylnucleoside antibiotic with antibacterial activities. A201A is highly effective against Gram-positive and most Gram-negative anaerobic bacteria. A201A inhibits tRNA accommodation during translation .
|
-
- HY-W275220
-
|
|
Aminoacyl-tRNA Synthetase
|
Infection
|
|
PEA-NBOMe hydrochloride (Compound 21) is a competitive phenylalanyl-tRNA synthetase (PRS) inhibitor (Ki=0.92 μM), which is found in Escherichia coli. PEA-NBOMe hydrochloride is promising for research of antibacterial or antiviral agents .
|
-
- HY-N2754
-
|
Eriodictyol 7-methyl ether; 7-O-Methyleriodictyol
|
Bacterial
|
Infection
Cardiovascular Disease
|
|
Sternbin (Eriodictyol 7-methyl ether) is a flavanone and antibacterial agent. Sternbin can be isolated from Heliotropium sinuatum. Sternbin has antibacterial activity against a wide range of bacteria. Sternbin has antiviral activity against infectious salmon anemia virus (ISAV). Sternbin inhibits the contraction of isolated rat smooth muscle .
|
-
- HY-P5683
-
|
|
Bacterial
|
Infection
|
|
Maximin 45 is an antimicrobial peptide. Maximin 41 has antibacterial activity against S. aureus, E. coli, B. subtilis (MIC: 4.7, 9.4, 75 μg/mL). Maximin 45 has hemolytic activities against human and rabbit red cells .
|
-
- HY-N7252R
-
|
|
Reference Standards
Bacterial
|
Infection
|
|
Daphnin (Standard) is the analytical standard of Daphnin. This product is intended for research and analytical applications. Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .
|
-
- HY-173594
-
|
|
Bacterial
|
Infection
|
|
TarO-IN-1 (Compound 18a) is a TarO inhibitor and has antibacterial activity. TarO-IN-1 has β-lactam sensitizing and anti-biofilm activities against MRSA. TarO-IN-1 can be used for research of β-lactam resistance .
|
-
- HY-169105
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL .
|
-
- HY-N10617
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Hygromycin A is a Borrelia burgdorferi-selective antibiotic. Hygromycin A is a spirochete-specific antibacterial that is conducive to gut health. Hygromycin A can be used for Lyme disease research .
|
-
- HY-151875
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
MurA-IN-3 is a reversible pyrrolidinedione-based MurA inhibitor. MurA-IN-3 has inhibitory activity for MurA with an IC50 value of 4.5 μM. MurA-IN-3 also has antibacterial activity .
|
-
- HY-N3307
-
-
- HY-Y0055R
-
|
Thiodiphenylamine (Standard)
|
Reference Standards
Antibiotic
Fungal
Bacterial
Parasite
|
Infection
Neurological Disease
|
|
Phenothiazine (Standard) is the analytical standard of Phenothiazine. This product is intended for research and analytical applications. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases .
|
-
- HY-133592
-
|
|
Bacterial
|
Infection
|
|
Neoabietic acid, an abietic-type acid, is a nature product that could be isolated from the oleoresin and rosin of Pinus palustris. Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity .
|
-
- HY-111190
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Thiotropocin is a tropothione Antibiotic with antibacterial activities against Gram-positive and Gram-negative bacteria, some phytopathogens and mycoplasma. Thiotropocin causes morphological changes of Proteus mirabilis and Escherichia coli .
|
-
- HY-N7116
-
|
2-Methoxy-1,4-naphthoquinone
|
Fungal
Bacterial
|
Infection
|
|
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities .
|
-
- HY-12888
-
|
|
Topoisomerase
Bacterial
|
Infection
|
|
AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria .
|
-
- HY-B1050
-
|
SB-265805S; LB-20304a
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
|
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-174323
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Anti-MRSA agent 28 is an antibacterial agent against multidrug resistant (MDR) gram-positive strains with MICs of 0.06-0.125 μg/mL. Anti-MRSA agent 28 can target DNA polymerase IIIC to reduce the amount of genomic DNA with the IC50 of 3.80 μg/mL. Anti-MRSA agent 28 has good antibacterial activity and reduces inflammation. Anti-MRSA agent 28 can be used against gram-positive strains and infectious conditions.
|
-
- HY-P5686
-
|
|
Bacterial
|
Infection
|
|
Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .
|
-
- HY-138179
-
|
|
Bacterial
|
Infection
|
|
7-APRA is a semi-synthetic intermediate of cephalosporin antibiotics. 7-APRA has antibacterial activity and is mainly used in the synthesis of other Cefaclor (HY-B0198) and Cefprozil (HY-B0458A) .
|
-
- HY-N0709R
-
-
- HY-119815
-
|
|
Bacterial
|
Infection
|
|
Tenonitrozole exhibits antibacterial activity through inhibition of pyruvate-ferredoxin oxidoreductase (PFOR). Tenonitrozole inhibits H. pylori and C. jejuni with MICs of 0.7 μM and 5.9 μM .
|
-
- HY-130281
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
Ianthelliformisamine B diTFA is a bromotyrosine-derived antibacterial agent. Ianthelliformisamine B diTFA is against E. coli and S. aureus strains with MICs of 14.5 μM and 144.7 μM .
|
-
- HY-W013409
-
|
|
Bacterial
|
Infection
Cancer
|
|
2,4-Dichlorobenzenesulfonyl chloride (Compound 6d) is a heterocyclic building block, which can be used in the synthesis of nicotinyl arylsulfonylhydrazides with anticancer and antibacterial activities .
|
-
- HY-N3345
-
|
|
Bacterial
|
Infection
|
|
Macrocarpal B is an antibacterial compounds. Macrocarpal B can be isolated from the branch of Eucalyptus globulus. Macrocarpal B can be used for the research of periodontal disease .
|
-
- HY-W014612
-
|
Acetyleugenol
|
Fungal
Bacterial
Endogenous Metabolite
|
Infection
Inflammation/Immunology
Cancer
|
|
Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .
|
-
- HY-N15359
-
|
|
Bacterial
|
Infection
|
|
Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .
|
-
- HY-129806
-
|
(+)-Rugulosin
|
Bacterial
Fungal
|
Infection
|
|
Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity .
|
-
- HY-76228
-
|
Pyrazole
|
Drug Intermediate
Biochemical Assay Reagents
|
Infection
Inflammation/Immunology
|
|
1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
|
-
- HY-P5684
-
|
|
Bacterial
|
Infection
|
|
Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .
|
-
- HY-146650
-
|
|
Bacterial
|
Infection
Cardiovascular Disease
|
|
LpxC-IN-9 (compound 19) is a potent LpxC inhibitor. LpxC-IN-9 has antibacterial and hypotensive effects . LpxC-IN-9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W049970R
-
|
|
Reference Standards
Bacterial
|
Infection
|
|
Carvacrol methyl ether (Standard) is the analytical standard of Carvacrol methyl ether. This product is intended for research and analytical applications. Carvacrol methyl ether is a carvacrol derivative isolated from plant volatile oil. Carvacrol methyl ether exhibits antibacterial activity. Carvacrol methyl ether is a proton acceptor .
|
-
- HY-N9709
-
|
|
Bacterial
|
Infection
|
|
5-Hydroxysophoranone is a flavanone that can be isolated from the Erythrina subumbrans. 5-Hydroxysophoranone shows weak antibacterial activity against several strains of Streptococcus .
|
-
- HY-19285A
-
|
Sulfachloropyrazine sodium
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis) .
|
-
- HY-W013158
-
|
|
Dynamin
|
Infection
|
|
Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC50 value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus .
|
-
- HY-19285
-
|
Sulfachloropyrazine
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis) .
|
-
- HY-120183
-
|
|
Fungal
|
Infection
|
|
Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .
|
-
- HY-B1852R
-
|
|
Bacterial
Reference Standards
Fungal
|
Infection
|
|
Sulfometuron-methyl (Standard) is the analytical standard of Sulfometuron-methyl. This product is intended for research and analytical applications. Sulfometuron-methyl is a herbicide and also a powerful inhibitor of the enzyme acetolactate synthase (ALS). It exhibits antibacterial and antifungal activities, capable of inhibiting the activity of Salmonella. typhimurium ALS II and Escherichia. coli ALS III .
|
-
- HY-P0230
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III .
|
-
- HY-D0896A
-
|
NSC 1746 ammonium; Peri acid, phenyl- ammonium; Phenyl peri acid ammonium
|
Bacterial
|
Infection
|
|
ANS ammonium is a potent antibacterial agent and a textile dye. ANS ammonium can be used as fluorescence probe. ANS ammonium blocks the binding of triiodothyronine to thyroxine binding globulin in radioimmunoassay of triiodothyronine .
|
-
- HY-B0512S
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Sulfamerazine-d4 is a deuterium labeled Sulfamerazine. Sulfamerazine, a sulfonamide antibacterial, inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes .
|
-
- HY-113602
-
|
Antibiotic 273 A1-beta
|
Antibiotic
Bacterial
|
Infection
|
|
Paldimycin B (Antibiotic 273 A1-beta) is a powerful semi-synthetic antibiotic with antibacterial activity against S. aureus and coagulase-negative staphylococci .
|
-
- HY-B1825R
-
|
|
Reference Standards
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
|
Cefoxitin (Standard) is the analytical standard of Cefoxitin. This product is intended for research and analytical applications. Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-176730
-
|
|
Bacterial
|
Infection
|
|
HC2210 has an antibacterial effect against Mycobacterium abscessus (Mab) (EC50: 0.72 µM). HC2210 modulates the expression of Mab genes related to oxidative stress and lipid metabolism. HC2210 can be used in the study of Mab infection .
|
-
- HY-111396
-
|
|
Bacterial
|
Infection
|
|
PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis .
|
-
- HY-151352
-
|
|
Bacterial
|
Infection
|
|
DHDPS-IN-1 (compound 8) is a DHDPS inhibitor (IC50: 39 μM). DHDPS-IN-1 can be used in the area of antibacterial and herbicidal .
|
-
- HY-B1085R
-
|
Compound 64716 (Standard)
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
|
Cinoxacin (Standard) is the analytical standard of Cinoxacin. This product is intended for research and analytical applications. Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .
|
-
- HY-16752
-
|
MK-7655
|
Beta-lactamase
Bacterial
|
Infection
|
|
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .
|
-
- HY-P5561
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .
|
-
- HY-170489
-
|
|
Bacterial
Fungal
Toll-like Receptor (TLR)
|
Infection
Inflammation/Immunology
|
|
Antifungal agent 123 (Compound 4b) exhibits good affinity to the oxidoreductase of Staphylococcus aureus or the membrane protein of Candida albicans, exhibits antibacterial and antifungal activities. Antifungal agent 123 scavenges free radical, exhibits antioxidant efficacy. Antifungal agent 123 inhibits the TLR signaling pathway, and exhibits anti-inflammatory efficacy .
|
-
- HY-163338
-
|
|
Beta-lactamase
|
Infection
|
|
Metallo-β-lactamase-IN-13 (Compound 13i) is a pan Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-13 provides broader coverage of metallo-β-lactamases expressing Gram-negative (GN) bacteria. Metallo-β-lactamase-IN-13 has antibacterial activity against P. aeruginosa .
|
-
- HY-W286362
-
|
Palmitic acid anilide
|
Bacterial
|
Infection
|
|
Palmitanilide (Palmitic acid anilide) is an antibacterial agent against Gram-positive bacteria. Palmitanilide can electrostatically bind to relevant components in the cell walls of Gram-positive bacteria (such as Bacillus cereus), alter the cell membrane structure, and affect the normal functions of the cells. Palmitanilide is promising for research of infectious diseases caused by Gram-positive bacteria .
|
-
- HY-N7057R
-
|
Pelargonic acid (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
Nonanoic acid (Standard) is the analytical standard of Nonanoic acid. This product is intended for research and analytical applications. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2 .
|
-
- HY-119502
-
-
- HY-B0946
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
|
-
- HY-B1050R
-
|
SB-265805S (Standard); LB-20304a (Standard)
|
Reference Standards
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
|
Gemifloxacin (mesylate) (Standard) is the analytical standard of Gemifloxacin (mesylate). This product is intended for research and analytical applications. Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-N10227
-
-
- HY-120382
-
|
|
Bacterial
|
Infection
|
|
LY 215890 ia an orally active antibacterial agent aganist Escherichia coli EC14 and Klebsiella pneumonia X26 .
|
-
- HY-107923
-
|
N1-Acetylsulfisoxazole
|
Bacterial
|
Infection
|
|
Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action .
|
-
- HY-N13301
-
-
- HY-N13008
-
|
|
Bacterial
|
Infection
|
|
4-Hydroxy-sterigmatocystin (compd 1) is a ParB inhibitor with antibacterial activity. 4-Hydroxy-sterigmatocystin can bind to purified ParB in a ParS-modulated manner and inhibits its ParS-dependent CTPase activity .
|
-
- HY-106594A
-
|
Iron(III) ferrocyanide; Milori blue
|
Bacterial
|
Infection
Cancer
|
|
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .
|
-
- HY-106594B
-
|
Pigment blue 27
|
Bacterial
|
Infection
Cancer
|
|
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .
|
-
- HY-P10548
-
|
|
Bacterial
|
Infection
|
|
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents .
|
-
- HY-150637
-
|
|
Bacterial
|
Infection
|
|
Mab Aspartate Decarboxylase-IN-1 is a potent aspartate decarboxylase (PanD) inhibitor with an IC50 value of 56.3 μM. Mab Aspartate Decarboxylase-IN-1 shows antibacterial activity .
|
-
- HY-N0872
-
-
- HY-122069
-
|
NSC 1
|
Bacterial
|
Infection
Neurological Disease
Cancer
|
|
NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC50s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent .
|
-
- HY-19160
-
|
PA-1806; BMS 180680-01
|
Antibiotic
Bacterial
|
Infection
|
|
BMS-180680 (PA-1806) is an antibiotic, which exhibits a board-spectrum antibacterial activity against gram-negative bacteria. BMS-180680 inihibits Pseudomonas aeruginosa with MIC of 0.25 µg/ml. BMS-180680 exhibits resistance to hydrolysis by β-lactamases, such as TEM-2 and PSE enzymes .
|
-
- HY-144121
-
|
|
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities .
|
-
- HY-157045
-
|
|
ATP Synthase
|
Infection
|
|
ATP Synthesis-IN-1 (Compound 4), quinoline derivative, is a potent inhibitor of PA ATP synthesis activity. ATP Synthesis-IN-1 has PA ATP synthesis inhibition with IC50 value of 11.1μg/mL. ATP Synthesis-IN-1 also has antibacterial activity. ATP Synthesis-IN-1 can be used for the research of drug-resistant PA infection .
|
-
- HY-N12343
-
|
|
Bacterial
Fungal
|
Infection
|
|
Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities .
|
-
- HY-W017241
-
|
1-Hydroxymethylnaphthalene
|
Bacterial
Biochemical Assay Reagents
|
Infection
|
|
1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research .
|
-
- HY-B1085S
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Cinoxacin-d5 is the deuterium-labeled Cinoxacin (HY-B1085) . Cinoxacin (Compound 64716)，a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis .
|
-
- HY-P3459A
-
|
|
Bacterial
|
Infection
|
|
Tet-213 TFA is a antimicrobial peptide. Tet-213 TFA has broad spectrum antibacterial activity. Tet-213 TFA can promote infected wound repair .
|
-
- HY-B0963
-
|
5-Chloro-8-quinolinol
|
Bacterial
Fungal
Parasite
PPAR
|
Infection
Cancer
|
|
Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ .
|
-
- HY-155715
-
|
|
Glucosylceramide Synthase (GCS)
Bacterial
|
Infection
|
|
G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study .
|
-
- HY-N15028
-
|
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
Depsidomycin is an immunomodulatory antibiotic with immunosuppressive activity that can be isolated from the culture broth of Streptomyces lavendofoliae MI951-62F2. Depsidomycin primarily exhibits antibacterial activity against Gram-positive bacteria .
|
-
- HY-W083376A
-
|
|
Keap1-Nrf2
|
Inflammation/Immunology
Cancer
|
|
4-Methoxychalcone is a naturally occurring chalcone compound. 4-Methoxychalcone has antioxidant activity, anti-inflammatory activity, antitumor activity and antibacterial activity. 4-Methoxychalcone can be used to study inflammation and tumor models .
|
-
- HY-137139
-
|
|
Antibiotic
Bacterial
Farnesyl Transferase
|
Infection
Cancer
|
|
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg) .
|
-
- HY-121054R
-
|
|
Bacterial
Parasite
|
Inflammation/Immunology
Cancer
|
|
Chalcone (Standard) is the analytical standard of Chalcone. This product is intended for research and analytical applications. Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
|
-
- HY-W587957
-
|
|
Bacterial
Parasite
|
Infection
|
|
Gypsogenic acid is a triterpenoid acid that can be isolated from Miconia stenostachya and has antibacterial and trypanoidal activities. The MICs values of Gypsogenic acid for the oral bacterial pathogens Enterococcus faecalis, Streptococcus salivarius, Streptococcus haematococcus, Streptococcus mutans and sobrinus were 50-200 μg/mL. Gypsogenic acid can induce blood cortensite cleavage in isolated mice with IC50 56.6 μM .
|
-
- HY-P5710
-
|
|
Bacterial
|
Infection
|
|
LCI peptide is an antimicrobial peptide with antibacterial activity. LCI peptide is active against plant pathogens, Xanthomonas and Pseudomonas, including E. coli, Gentamicin-resistant MRSA and Xoo .
|
-
- HY-N10774
-
|
|
Bacterial
|
Infection
|
|
Viroxocin is a diterpenoid. Viroxocin can be isolated from the roots of Salvia viridis L. cvar. Blue Jeans. Viroxocin also has weak antibacterial activity .
|
-
- HY-B1374R
-
|
(-)-Florfenicol (Standard); SCH-25298 (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
Florfenicol (Standard) is the analytical standard of Florfenicol. This product is intended for research and analytical applications. Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions .
|
-
- HY-W015879R
-
|
|
Reference Standards
Bacterial
|
Inflammation/Immunology
|
|
2-Heptanol (Standard) is the analytical standard of 2-Heptanol. This product is intended for research and analytical applications. 2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties[1][2].
|
-
- HY-N10272
-
|
|
Fungal
Bacterial
|
Infection
|
|
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .
|
-
- HY-W014612R
-
|
Acetyleugenol (Standard)
|
Fungal
Bacterial
Endogenous Metabolite
Reference Standards
|
Infection
Inflammation/Immunology
Cancer
|
|
Eugenol acetate (Standard) is the analytical standard of Eugenol acetate. This product is intended for research and analytical applications. Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .
|
-
- HY-120747
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II .
|
-
- HY-B1526
-
|
Thioacetazone; Amithiozone
|
Bacterial
Antibiotic
|
Infection
|
|
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL .
|
-
- HY-Y0585
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis [1][4].
|
-
- HY-165126
-
|
SPG
|
Bacterial
Parasite
|
Infection
Cancer
|
|
Schizophyllan (SPG), a member of the β-glucan family, is an exopolysaccharide with antineoplastic, antibacterial activities and antiparasitic properties. Schizophyllan can be used for petroleum recovery, a thickener for cosmetic lotions, oxygen impermeable films for food preservation, and high-value pharmaceutical applications .
|
-
- HY-113590
-
|
|
Bacterial
|
Infection
|
|
FR295389 is a dihydroimidazopyrazolium cephalosporin with antibacterial activity. FR295389 shows activity against IMP-type metallo-β-lactamases (MBL)-producing Klebsiella pneumoniae, Acinetobacter baumanii and Pseudomonas putida with MIC values ranging from 4 to 32 mg/mL .
|
-
- HY-B1610
-
|
Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate
|
Bacterial
Endogenous Metabolite
Apoptosis
|
Infection
Cardiovascular Disease
Cancer
|
|
Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .
|
-
- HY-N0681
-
|
Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt
|
Reactive Oxygen Species (ROS)
|
Metabolic Disease
Inflammation/Immunology
Endocrinology
|
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .
|
-
- HY-N7851
-
|
|
Others
|
Infection
Others
Inflammation/Immunology
|
|
Terpineol is a monoterpenoid alcohol compound that is widely found in plants, especially in the peels of citrus fruits. Terpineol has antioxidant, anti-inflammatory and antibacterial activities and is commonly used in the fragrance industry as an additive in food, beverages, cosmetics and perfumes .
|
-
- HY-N12023
-
|
|
Bacterial
Fungal
|
Infection
Cancer
|
|
Deacetylnomilin can be isolated from Citrus reticulata and has antibacterial and antifungal activity. Deacetylnomilin is a potent inhibitor of cell proliferation with an IC50 value of 0.005 ug/mL against estrogen receptor-positive (ER+) cells .
|
-
- HY-133592R
-
|
|
Reference Standards
Bacterial
|
Infection
|
|
Neoabietic acid (Standard) is the analytical standard of Neoabietic acid. This product is intended for research and analytical applications. Neoabietic acid, an abietic-type acid, is a nature product that could be isolated from the oleoresin and rosin of Pinus palustris. Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity .
|
-
- HY-76228R
-
|
|
Drug Intermediate
Biochemical Assay Reagents
|
Infection
Inflammation/Immunology
|
|
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
|
-
- HY-P10349
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Pap12-6 is a 12-mer peptide derived from the antimicrobial peptide Papiliocin of yellow butterfly larva. Pap12-6 kills bacteria by penetrating and disrupting their membranes, exhibiting strong antibacterial activity. Pap12-6 exerts its anti-inflammatory effects through the TLR4-mediated NF-κB signaling pathway .
|
-
- HY-N6810
-
Thymol
3 Publications Verification
|
Bacterial
Fungal
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects .
|
-
- HY-N7430
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
3-O-Methylellagic acid is a nature product that can be isolated from Myrciaria cauliflora, with anti-inflammatory activity. 3-O-Methylellagic acid shows an inhibitory effect on glucose transport assay. 3-O-Methylellagic acid has antibacterial activity, with a MIC of 32 μg/mL for Staph. Aureus ATCC 25923 .
|
-
- HY-14780
-
|
NXL 101
|
Antibiotic
Topoisomerase
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L .
|
-
- HY-N0312
-
|
|
Phosphatase
Bacterial
|
Infection
Metabolic Disease
|
|
Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC50 of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects .
|
-
- HY-107329
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Cefathiamidine is a first-generation cephalosporin antibacterial agent and is used to treat infections caused by susceptible bacteria. Cefathiamidine exhibits a wide spectrum of antimicrobial activity against bacteria. Cefathiamidine is used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis .
|
-
- HY-134900R
-
|
|
Reference Standards
Reactive Oxygen Species (ROS)
|
Infection
Metabolic Disease
|
|
Allyl methyl trisulfide (Standard) is the analytical standard of Allyl methyl trisulfide. This product is intended for research and analytical applications. Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities[1].
|
-
- HY-N0253
-
|
Kalopanaxsaponin B
|
Bacterial
p38 MAPK
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
|
|
Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity .
|
-
- HY-N4033
-
|
7α-Hydroxyroyleanone
|
Bacterial
|
Infection
|
|
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .
|
-
- HY-N6310
-
|
|
Bacterial
|
Infection
|
|
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC50 of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC50 of 7.49 μM .
|
-
- HY-W127616A
-
|
Sitosteryl acetate, 95%
|
Bacterial
|
Infection
|
|
β-Sitosterol acetate, 95% (Sitosteryl acetate, 95%) is a sterol that can be isolated from Hechtia glomerata Zucc., which has antibacterial activity and has a MIC value of 100µg/mL against carbapenem-resistant Acinetobacter baumannii .
|
-
- HY-161756
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-10 is a potent DNA gyrase inhibitor with potent antibacterial effects. DNA Gyrase-IN-10 has inhibitory effects on both Gram-positive and Gram-negative bacteria .
|
-
- HY-128913
-
|
|
Bacterial
|
Infection
|
|
1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one is an acridone alkaloid compound isolated from the fruits of Z. leprieurii and Z. zanthoxyloides. 1,3-Dihydroxy-4-methoxy-10-methylacridin-9(10H)-one has antibacterial activity .
|
-
- HY-N6294
-
|
|
Bacterial
Fungal
|
Infection
|
|
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
|
-
- HY-B0692A
-
|
BMY-28142 chloride
|
Penicillin-binding protein (PBP)
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cefepime (BMY-28142) chloride is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime chloride shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime chloride induces neurotoxicity .
|
-
- HY-B0212
-
|
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .
|
-
- HY-B0692
-
-
- HY-125104
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Mirosamicin is an antibiotic with high antibacterial activity that targets a wide range of gram-positive bacteria and certain Gram-negative bacteria as well as mycoplasma. Mirosamicin can be used for research in the field of food safety monitoring .
|
-
- HY-105033
-
|
Pirfloxacin
|
Bacterial
|
Infection
|
|
Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active .
|
-
- HY-146177
-
|
|
Bacterial
Cytochrome P450
|
Infection
|
|
CYP3A4 enzyme-IN-1 (compound 59) is a potent antibacterial agent, with a MIC of 1 μg/mL for MRSA. CYP3A4 enzyme-IN-1 exhibits low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6, and CYP3A4 enzymes .
|
-
- HY-128773
-
|
|
Bacterial
|
Infection
|
|
MRL-494, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias .
|
-
- HY-128773A
-
|
|
Bacterial
|
Infection
|
|
MRL-494 hydrochloride, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 hydrochloride can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias .
|
-
- HY-130718
-
|
|
Bacterial
|
Infection
Cancer
|
|
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities .
|
-
- HY-P5693
-
|
|
Bacterial
CMV
HSV
|
Infection
|
|
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .
|
-
- HY-19285AR
-
|
Sulfachloropyrazine sodium (Standard)
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Sulfaclozine (sodium) (Standard) is the analytical standard of Sulfaclozine (sodium). This product is intended for research and analytical applications. Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis) .
|
-
- HY-N13286
-
|
|
Bacterial
|
Infection
|
|
Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC50 values of 120.86 µg/mL and 97.74 µg/mL, respectively .
|
-
- HY-19285R
-
|
Sulfachloropyrazine (Standard)
|
Reference Standards
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Sulfaclozine (Standard) is the analytical standard of Sulfaclozine. This product is intended for research and analytical applications. Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis) .
|
-
- HY-119648
-
|
|
Bacterial
|
Infection
|
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents .
|
-
- HY-N15029
-
|
|
Antibiotic
Bacterial
Fungal
Parasite
Adenylate Cyclase
|
Infection
|
|
Destomycin A is an aminoglycoside antibiotic with antibacterial (Gram-positive bacteria, Gram-negative bacteria), antifungal and anthelmintic activities. Destomycin A inhibits the polypeptide synthesis in cells of Escherichia coli and stimulation of adenylate cyclase in animal tissues .
|
-
- HY-167651
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
TAN-1057C is a potent antibiotic which exhibits antibacterial activity against Gram-negative and Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus .
|
-
- HY-16752R
-
|
MK-7655 (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
|
Infection
|
|
Relebactam (Standard) is the analytical standard of Relebactam. This product is intended for research and analytical applications. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .
|
-
- HY-N7188
-
|
|
Bacterial
|
Infection
|
|
CJ-21,058 is a potent SecA inhibitor with an IC50 value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .
|
-
- HY-170810
-
|
|
Bacterial
|
Infection
|
|
E.coli Gyrase B-IN-1 (Compound 10g) is a E.coli Gyrase B inhibitor with antibacterial activities. E.coli Gyrase B-IN-1 has potent inhibitory activity against E. coli, with a MIC value of 0.12 mM. E.coli Gyrase B-IN-1 is promising for research of antimicrobial agents .
|
-
- HY-143408
-
|
|
Bacterial
|
Infection
|
|
OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains .
|
-
- HY-D0896AR
-
|
|
Bacterial
|
Infection
|
|
ANS (ammonium) (Standard) is the analytical standard of ANS (ammonium). This product is intended for research and analytical applications. ANS ammonium is a potent antibacterial agent and a textile dye. ANS ammonium can be used as fluorescence probe. ANS ammonium blocks the binding of triiodothyronine to thyroxine binding globulin in radioimmunoassay of triiodothyronine .
|
-
- HY-B2072AR
-
|
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Cefadroxil (hydrate) (Standard) is the analytical standard of Cefadroxil (hydrate). This product is intended for research and analytical applications. Cefadroxil hydrate (BL-S 578 hydrate) is an orally active and first-generation cephalosporin with a broad spectrum antibacterial activity. Cefadroxil hydrate (BL-S 578 hydrate) also acts as a substrate of the peptide transporter PEPT1 and PEPT2 .
|
-
- HY-P5702
-
|
|
Bacterial
Apoptosis
Fungal
|
Infection
|
|
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .
|
-
- HY-100500
-
|
KBT 1585 hydrochloride
|
Penicillin-binding protein (PBP)
Bacterial
|
Infection
Cancer
|
|
Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active proagent of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection .
|
-
- HY-B0947
-
|
|
P-glycoprotein
Bacterial
|
Infection
|
|
Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
|
-
- HY-B0946S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulfamonomethoxine-d4 is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
|
-
- HY-133119
-
|
|
Bacterial
|
Infection
|
|
PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 μM, respectively .
|
-
- HY-164123
-
|
|
Bacterial
|
Infection
|
|
Antibiofilm agent-9 (Compound 4) is a pyrrolomycin derivative with antibacterial activity. Antibiofilm agent-9 inhibits Bacillus anthracis with MIC of 0.031 μg/mL. Antibiofilm agent-9 exhibits antibiofilm activity with 84% biofilm inhibition (24 h, 8.0 μg/mL). Antibiofilm agent-9 exhibits a good pharmacokinetic characters in mouse model .
|
-
- HY-A0166A
-
|
MK0791 sodium
|
Bacterial
Antibiotic
|
Infection
|
|
Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct .
|
-
- HY-N11920
-
-
- HY-A0166
-
|
MK0791
|
Bacterial
Antibiotic
|
Infection
|
|
Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct .
|
-
- HY-N10307
-
|
|
Fungal
Bacterial
Endogenous Metabolite
|
Infection
Cancer
|
|
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI50=4.4 µg/mL) .
|
-
- HY-114737
-
|
|
Bacterial
|
Infection
|
|
L-573655 is a reversible inhibitor of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase with an IC50 value of 8.5 μM. L-573655 possesses antibacterial activity against a wild-type strain of E. coli. with MIC values of 200-400 μg/mL .
|
-
- HY-N10607
-
|
|
Bacterial
|
Infection
|
|
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone (Compound 5) has antibacterial activity, with a MIC value of 10 μg/mL for E. coli and S. epidermis. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone can be isolated from Piper obliquum .
|
-
- HY-P0135
-
|
|
Bacterial
|
Infection
|
|
Penta lysine is an antibacterial agent, that inhibits E. coli, A. baumannii, P. aeruginos, S. aureus, and B. subtilis, with MIC of 1.1-18 μM .
|
-
- HY-119502R
-
|
|
Reference Standards
Reactive Oxygen Species (ROS)
Fungal
Bacterial
|
Infection
Cancer
|
|
Camalexin (Standard) is the analytical standard of Camalexin. This product is intended for research and analytical applications. Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].
|
-
- HY-N0872R
-
-
- HY-135652
-
|
Hexyl 3,4,5-trihydroxybenzoate
|
Bacterial
Parasite
|
Infection
|
|
Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR . Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM .
|
-
- HY-D1020
-
-
- HY-B0771
-
|
SCE-2787
|
Bacterial
Antibiotic
|
Infection
|
|
Cefozopran (SCE-2787) is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-B0771A
-
|
SCE-2787 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-N7449
-
-
- HY-B0963R
-
|
5-Chloro-8-quinolinol (Standard)
|
Reference Standards
Bacterial
Fungal
Parasite
PPAR
|
Infection
Cancer
|
|
Cloxiquine (Standard) is the analytical standard of Cloxiquine. This product is intended for research and analytical applications. Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ .
|
-
- HY-16137
-
|
Cephaloglycin
|
Bacterial
|
Infection
|
|
Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration .
|
-
- HY-W041988
-
|
|
Bacterial
|
Infection
|
|
Fmoc-Glu-OMe, a glutamic acid derivative, shows antibacterial activity and gelation property in AgNO3 solution. Fmoc-Glu-OMe is a mouldable wound healing biomaterial .
|
-
- HY-N1672
-
|
|
Others
|
Infection
|
|
5,7,2 ',6 '-Tetrahydroxyflavanone is an extract isolated from Scutellaria baicalensis. 5,7,2 ',6 '-Tetrahydroxyflavanone has significant antibacterial activity against gram-positive bacteria. 5,7,2 ',6 '-Tetrahydroxyflavanone can be used to study the treatment of inflammatory diseases .
|
-
- HY-156416
-
|
|
Bacterial
|
Infection
|
|
LtaS-IN-2 (compound 13) is a inhibitor of LTA synthesis, and shows antibacterial activity against S. aureus and S. epidermidis, with the MIC90 of 0.5 μg/mL and 1 μg/mL, respectively. LtaS-IN-2 is a derivative of LtaS-IN-1 (HY-135813) .
|
-
- HY-N7652
-
|
|
Bacterial
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
|
Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research .
|
-
- HY-100711
-
|
Prodigiosine; NSC47147
|
Bacterial
Apoptosis
Wnt
Fungal
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
|
-
- HY-136559
-
-
- HY-156289
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 8 (Compound 7g) is a DAPG derivative with strong antibacterial activity. Anti-MRSA agent 8 assertes its activity by targeting bacterial cell membranes. Anti-MRSA agent 8 can be used for the research of methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-172229
-
|
|
Topoisomerase
Bacterial
|
Infection
|
|
NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection .
|
-
- HY-169823
-
|
|
Bacterial
Drug Derivative
|
Infection
|
|
BAS-118 is a benzamide derivative with antibacterial activity. The MIC50, MIC90 and MIC ranges of BAS-118 for 100 randomly selected isolates of Helicobacter pylori are ≤0.003, 0.013 and ≤0.003-0.025 mg/L, respectively. BAS-118 is promising for research of anti-H. pylori agent .
|
-
- HY-N2417
-
|
|
Bacterial
|
Infection
|
|
Stearyl glycyrrhetinate, a major component in licorice extract, has a MIC against S. aureus strains of more than 256 mg/L. Stearyl glycyrrhetinate has antibacterial effects .
|
-
- HY-N6810R
-
|
|
Reference Standards
Bacterial
Fungal
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
Thymol (Standard) is the analytical standard of Thymol. This product is intended for research and analytical applications. Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects .
|
-
- HY-B1610R
-
|
Trisodium citrate dihydrate (Standard); Citric acid trisodium salt dihydrate (Standard)
|
Reference Standards
Bacterial
Endogenous Metabolite
Apoptosis
|
Infection
Cardiovascular Disease
Cancer
|
|
Sodium citrate (dihydrate) (Standard) is the analytical standard of Sodium citrate (dihydrate). This product is intended for research and analytical applications. Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .
|
-
- HY-P5697
-
|
|
Bacterial
|
Infection
|
|
Tilapia piscidin 3 is an antimicrobial peptide with antibacterial activity against gram-positive and -negative bacteria (MIC: 2.44, 2.44, 9.78, 19.55, 0.61 μg/mL for V. vulnificus 204, V. alginolyticus, S. agalactiae 819, E. faecalis BCRC 10066, S. agalactiae BCRC 10787). Tilapia piscidin 3 has hemolytic activity in fish red blood cells .
|
-
- HY-113687
-
|
|
Bacterial
|
Infection
|
|
T145 is an oxazolidinone with antibacterial activity that inhibits growth of gram negatives (K. pneumoniae, A. baumannii, P. aeruginosa and E. cloacae), gram positives (E. faecalis and S. aureus) and acid fast pathogens (Mab, Mav and Mtb) .
|
-
- HY-N9488
-
|
Girinimbin
|
Apoptosis
Bacterial
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .
|
-
- HY-N7504
-
|
|
Bacterial
|
Infection
Metabolic Disease
Cancer
|
|
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .
|
-
- HY-143452
-
|
|
Tyrosinase
Bacterial
|
Inflammation/Immunology
|
|
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent .
|
-
- HY-B0946R
-
|
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Sulfamonomethoxine (Standard) is the analytical standard of Sulfamonomethoxine (HY-B0946). This product is intended for research and analytical applications. Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
|
-
- HY-W250978
-
|
|
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Ovalbumins (OVA), the main protein found in egg whites, have various biological activities such as anticancer, antihypertensive, antibacterial, antioxidant and immunomodulatory activities. Ovalbumins are the most abundant proteins synthesized in progesterone- or estrogen-treated fallopian tubes and are commonly used as markers to study hormone regulation of gene expression in tissues .
|
-
- HY-154861
-
|
|
Bacterial
Apoptosis
Necroptosis
|
Cancer
|
|
Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research .
|
-
- HY-P2317A
-
|
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection .
|
-
- HY-A0090A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Nitrofurantoin sodium is a potent and orally active antibacterial agent. Nitrofurantoin sodium acts as an antibiotic. Nitrofurantoin sodium can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
- HY-100711A
-
|
Prodigiosine hydrochloride
|
Bacterial
Apoptosis
Fungal
Wnt
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
|
-
- HY-121412
-
|
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Lankacidin C is an inhibitor of protein synthesis in vitro. Lankacidin C inhibits the activity of L1210 leukemia, B16 melanoma and 6C3 HED/OG lymphosarcoma cell lines. Lankacidin C has antibacterial activity and antitumor activity .
|
-
- HY-172895
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Quorum sensing-IN-10 (10p), an antibacterial synergist, shows significant inhibition of P. aeruginosa virulence, biofilm, and motility, with low toxicity. Quorum sensing-IN-10 (10p) can be used in the research for drug-resistant Pseudomonas aeruginosa infections .
|
-
- HY-107329R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cefathiamidine (Standard) is the analytical standard of Cefathiamidine. This product is intended for research and analytical applications. Cefathiamidine is a first-generation cephalosporin antibacterial agent and is used to treat infections caused by susceptible bacteria. Cefathiamidine exhibits a wide spectrum of antimicrobial activity against bacteria. Cefathiamidine is used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis[1][2].
|
-
- HY-155127
-
|
|
Fungal
|
Cancer
|
|
Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL .
|
-
- HY-B0991
-
-
- HY-115349
-
|
|
Antibiotic
Bacterial
|
Infection
Neurological Disease
Cancer
|
|
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities .
|
-
- HY-P3328
-
|
|
Bacterial
|
Infection
|
|
MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
|
-
- HY-P3328A
-
|
|
Bacterial
|
Infection
|
|
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
|
-
- HY-N1671
-
|
|
Others
|
Infection
|
|
2',5,6',7-Tetraacetoxyflavanone is an extract isolated from Scutellaria baicalensis. 2',5,6',7-Tetraacetoxyflavanone shows significant antibacterial activity against gram-positive bacteria. 2',5,6',7-Tetraacetoxyflavanone can be used to study the treatment of inflammatory diseases .
|
-
- HY-B1526R
-
|
Thioacetazone (Standard); Amithiozone (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Thiacetazone (Standard) is the analytical standard of Thiacetazone. This product is intended for research and analytical applications. Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].
|
-
- HY-N10259
-
|
|
Bacterial
|
Infection
Cancer
|
|
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC50 of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC50=265 μM) .
|
-
- HY-N8213
-
-
- HY-Y0585R
-
|
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
|
|
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .
|
-
- HY-P2483A
-
|
|
Bacterial
|
Others
|
|
Octaarginine TFA is a cell-penetrating peptide (CPP). CPPs show membrane translocation activities. CPPs are used for intracellular delivery of various membrane-impermeable bioactive agents because of their intrinsic ability to gain access to cell interiors. CPPs have also been used to deliver antibacterial agents to target intracellular bacteria .
|
-
- HY-N11415
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .
|
-
- HY-N0253R
-
|
Kalopanaxsaponin B (Standard)
|
Reference Standards
Bacterial
p38 MAPK
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
|
|
Hederacoside C (Standard) is the analytical standard of Hederacoside C. This product is intended for research and analytical applications. Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity .
|
-
- HY-P5703
-
|
|
Bacterial
Apoptosis
Fungal
|
Infection
|
|
EP5-1 is an antimicrobial peptide. EP5-1 has antibacterial and antifungal activities. EP5-1 also shows antitumor activity against cancer cells, and induces cell apoptosis. EP5-1 has antiviral activity against pseudorabies virus (PRV) .
|
-
- HY-B0692R
-
|
BMY-28142 (Standard)
|
Penicillin-binding protein (PBP)
Reference Standards
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cefepime (Standard) is the analytical standard of Cefepime. This product is intended for research and analytical applications. Cefepime (BMY-28142) is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime induces neurotoxicity .
|
-
- HY-168873
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 23 (compound 11) is a potent anti-methicillin-resistant Staphylococcus aureus agent. Anti-MRSA agent 23 shows antibacterial and antibiofilm activities. Anti-MRSA agent 23 accelerates the reconstruction and healing of MRSA-infected cutaneous wounds by decreasing bacterial loads, attenuating inflammation, and promoting angiogenesis .
|
-
- HY-B0395B
-
|
DU6859a monohydrate
|
Bacterial
Antibiotic
|
Infection
|
|
Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection .
|
-
- HY-135422
-
|
Methylustin
|
Bacterial
Fungal
|
Infection
|
|
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
|
-
- HY-W010365
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Rhodanine, which can be used for anticonvulsant, antibacterial, antiviral, and antidiabetic activities, is used to determine tanninase in tannic acid-degrading fungal cultures. Rhodanine is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .
|
-
- HY-111278
-
-
- HY-147988
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains .
|
-
- HY-135130
-
|
(-)-BABX
|
Bacterial
|
Infection
|
|
Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis .
|
-
- HY-126562
-
-
- HY-B0996
-
|
NSC-17764
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Hexetidine (NSC-17764) is an orally active antibacterial and antifungal agent with broad antibacterial and antifungal activity. Hexetidine combined with IPBC potentiates strong fungal growth inhibition properties. Hexetidine at concentrations greater than 0.1% can cause oral ulceration. Additionally, Hexetidine improves its plaque inhibiting activities combined with zinc and has been confirmed the effectiveness on purulent wound along with ultrasound. Hexetidine is a promising candidate for research in fungus-related diseases and soft tissue purulent-inflammatory
|
-
- HY-W075770
-
|
Nickel monoxide
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
Metabolic Disease
Cancer
|
|
Nickel(II) oxide is a chemical compound which nanoparticle form (NiO NPs) exhibits antibacterial, antifungal, antileishmanial, anti-diabetic and anticancer activities. NiO NPs can be activated by ultraviolet and visible light to generate reactive oxygen species, which may be the main cause for the antimicrobial potential .
|
-
- HY-12480
-
|
GSK 1322322
|
Bacterial
|
Infection
|
|
Lanopepden (GSK 1322322) is a peptidyl peptidase (PDF) inhibitor. Lanopepden inhibits PDF activity, preventing bacterial protein synthesis, thereby exerting antibacterial activity. Lanopepden is primarily effective against Gram-positive bacteria. Lanopepden is used in the study of acute bacterial skin and skin structure infections .
|
-
- HY-N2381
-
|
|
NF-κB
Parasite
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis .
|
-
- HY-B0947R
-
|
|
P-glycoprotein
Bacterial
Reference Standards
|
Infection
|
|
Sulfanitran (Standard) is the analytical standard of Sulfanitran. This product is intended for research and analytical applications. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
|
-
- HY-N2041
-
|
|
Endogenous Metabolite
NF-κB
Bacterial
|
Infection
Inflammation/Immunology
|
|
Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties .
|
-
- HY-77036
-
Furagin
1 Publications Verification
Furazidine; Furazidin
|
Antibiotic
Bacterial
Carbonic Anhydrase
|
Infection
Cancer
|
|
Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs) .
|
-
- HY-P5016A
-
|
|
Antibiotic
Fungal
Bacterial
|
Infection
Cancer
|
|
CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor .
|
-
- HY-B2144A
-
|
Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)
|
Bacterial
Fungal
|
Infection
Cancer
|
|
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
|
-
- HY-B2144B
-
|
Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000)
|
Bacterial
Fungal
|
Infection
Cancer
|
|
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
|
-
- HY-P5016
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
|
CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor .
|
-
- HY-N0565
-
|
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
|
Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
- HY-151284
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents .
|
-
- HY-171005
-
|
|
Bacterial
|
Infection
|
|
VPC162134 is an antibacterial agent, that inhibits H. pylori, C. jejuni, MRSA and S. epidermidis with MIC of 2.9, 17.5, 93.3 and 93.3 μM. VPC162134 is an inhibitor for pyruvate ferredoxin oxidoreductase (PFOR) .
|
-
- HY-168100
-
|
|
Bacterial
|
Infection
|
|
LpxC-IN-14 (compound 6i) is a potent LpxC inhibitor. LpxC-IN-14 shows antibacterial activity. LpxC-IN-14 shows low cytotoxicity. LpxC-IN-14 shows acceptable plasma protein binding .
|
-
- HY-170991
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides .
|
-
- HY-P10547
-
|
MAC-1 peptide
|
Bacterial
|
Infection
|
|
Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. Macropin has antibacterial activity against both Gram-positive and Gram-negative bacteria, and also exhibits inhibitory activity against fungi and moderate hemolytic activity against human erythrocytes. Macropin can be used in research on anti-infective therapy .
|
-
- HY-N11722
-
|
|
PPAR
Apoptosis
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Panduratin A, a natural chalcone compound, is a PPAR-α/δ activator. Panduratin A induces apoptosis, and promotes cell cycle arrest at G0/G1 phase in multiple hematologic malignant cell lines. Panduratin A has anticancer, antioxidant, anti-inflammatory, antibacterial, and antibiofilm activities .
|
-
- HY-A0166R
-
|
MK0791 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cilastatin (Standard) is the analytical standard of Cilastatin. This product is intended for research and analytical applications. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct .
|
-
- HY-A0166AR
-
|
MK0791 sodium (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cilastatin (sodium) (Standard) is the analytical standard of Cilastatin (sodium). This product is intended for research and analytical applications. Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3].
|
-
- HY-114585
-
|
|
Bacterial
|
Infection
Cancer
|
|
Sperabillin A is an antibacterial agent against gram-positive and gram-negative bacteria. Sperabillin A shows strong inhibition of human umbilical vein endothelial (HUVE) cell proliferation. Sperabillin A also shows anti-tumor acfivity against B16 melanoma in mouse .
|
-
- HY-P2460
-
|
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
SMAP-29, a promising antiinfective agent, is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide. SMAP-29 acts by permeabilizing bacterial membranes and inducing remarkable changes in the surface morphology of susceptible microorganism .
|
-
- HY-125703
-
|
|
Estrogen Receptor/ERR
Apoptosis
|
Infection
Inflammation/Immunology
Endocrinology
Cancer
|
|
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .
|
-
- HY-139010
-
|
CI-934
|
SARS-CoV
|
Infection
|
|
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria .
|
-
- HY-B0771AR
-
|
SCE-2787 hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cefozopran (hydrochloride) (Standard) is the analytical standard of Cefozopran (hydrochloride). This product is intended for research and analytical applications. Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms .
|
-
- HY-137990
-
|
|
Bacterial
Parasite
Phosphatase
|
Infection
Cancer
|
|
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .
|
-
- HY-161094
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity .
|
-
- HY-N3488
-
|
|
Topoisomerase
Bacterial
Fungal
|
Infection
Cancer
|
|
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .
|
-
- HY-P2454
-
|
|
Bacterial
|
Infection
|
|
CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent .
|
-
- HY-147948
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively .
|
-
- HY-119445A
-
|
2-O-beta-D-Glucopyranosyl-D-glucopyranose monohydrate
|
Biochemical Assay Reagents
|
Infection
Others
Cancer
|
|
Sophorose (2-O-beta-D-Glucopyranosyl-D-glucopyranose) monohydrate is the disaccharide component of microbial glycolipids, which are often used as biosurfactants due to their hydrophobicity. Sophorolipids also exhibit antibacterial, antifungal, spermicidal, virucidal, and anticancer activities. In studies of Trichoderma reesei fermentation, sophorose monohydrate has been identified as a potent inducer of cellulase gene expression .
|
-
- HY-10979
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases .
|
-
- HY-131907
-
|
|
Bacterial
|
Infection
|
|
LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively .
|
-
- HY-123914
-
|
|
Bacterial
|
Infection
|
|
P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance .
|
-
- HY-145286
-
|
|
Bacterial
|
Infection
Cancer
|
|
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent .
|
-
- HY-B1210
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-16745
-
|
KRP-AM1977
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
|
Lascufloxacin (KRP-AM1977X) is a potent and orally active fluoroquinolone antibacterial agent. Lascufloxacin potently inhibits infections caused by various pathogens, including quinolone-resistant strains. Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections .
|
-
- HY-126114
-
|
|
COX
Interleukin Related
Bacterial
Fungal
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .
|
-
- HY-W142073
-
|
7-Methyltryptophan
|
Amino Acid Derivatives
|
Infection
|
|
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
|
-
- HY-P2569
-
|
|
Apoptosis
|
Cancer
|
|
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .
|
-
- HY-N0983
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
1,3,7-Trihydroxy-2-prenylxanthone, a xanthone, shows weaker antibacterial activity. 1,3,7-Trihydroxy-2-prenylxanthone exhibits the MIC values of 6.25 mg/ml against VREs strains (E. faecalis, E. faecium, and E. gallinarum) .
|
-
- HY-N0055
-
|
3-O-Caffeoylquinic acid; Heriguard; NSC-407296
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species (ROS)
Bacterial
Influenza Virus
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
|
-
- HY-113806
-
|
(±)-Oleracein E
|
Bacterial
Influenza Virus
Apoptosis
|
Infection
Inflammation/Immunology
|
|
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis .
|
-
- HY-134635
-
|
|
Bacterial
Fungal
HIV
|
Infection
Neurological Disease
Cancer
|
|
Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM .
|
-
- HY-N10755A
-
|
|
Cytochrome P450
Bacterial
|
Infection
|
|
(±)-ε-Viniferin is a racemate of ε-Viniferin (HY-N3841). (±)-ε-Viniferin exhibits P450 inhibitory antioxidants, as well as hepato-protective and antimicrobial activities. (±)-ε-Viniferin has antibacterial and antibiofilm activity against Gram-positive bacteria Streptococcus pneumoniae with a MIC of 20 μM .
|
-
- HY-137960
-
|
|
Bacterial
|
Inflammation/Immunology
Cancer
|
|
O,O-Dimethyl-cannabigerol is a natural product from Cannabis sativa. O,O-Dimethyl-cannabigerol has an antibacterial effect on drug-resistant strains of Staphylococcus aureus (MIC ranging from 1 to 2 μg/mL) . O,O-Dimethyl-cannabigerol is a nonpsychoactive constituent .
|
-
- HY-151373
-
|
|
Bacterial
|
Infection
|
|
MurA-IN-2 (compound 37), a chloroacetamide fragment containing a primary aliphatic amine, is a potent MurA inhibitor with an IC50 value of 39 μM. MurA-IN-2 has antibacterial activity and inhibits the bacterial cell wall synthesis .
|
-
- HY-B0159
-
|
Q-35
|
Bacterial
Antibiotic
|
Infection
|
|
Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-N12743
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Farobin A is a natural compound with antibacterial, antioxidant and anti-inflammatory activities. Farobin A against Streptococcus mutans ATCC 25175 and Streptococcus sobrinus ATCC 33478. Farobin A shows anti-inflammatory activity on cytokine IL-6 and TNF-α .
|
-
- HY-N7505
-
|
|
Bacterial
|
Infection
|
|
Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .
|
-
- HY-125130
-
|
Hes-7-G
|
HMG-CoA Reductase (HMGCR)
Bacterial
Interleukin Related
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with Ki of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice .
|
-
- HY-146165
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .
|
-
- HY-N2041R
-
|
|
Reference Standards
Endogenous Metabolite
NF-κB
Bacterial
|
Infection
Inflammation/Immunology
|
|
Myristic acid (Standard) is the analytical standard of Myristic acid. This product is intended for research and analytical applications. Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties .
|
-
- HY-115990
-
|
|
Topoisomerase
Bacterial
|
Infection
|
|
Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .
|
-
- HY-115991
-
|
|
Topoisomerase
Bacterial
|
Infection
|
|
Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .
|
-
- HY-139805
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research .
|
-
- HY-122482
-
|
|
HIV
Reverse Transcriptase
Telomerase
Bacterial
|
Infection
Metabolic Disease
Cancer
|
|
β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively .
|
-
- HY-174459
-
|
|
Bacterial
Penicillin-binding protein (PBP)
|
Infection
|
|
Anti-MRSA agent 31 (Compound 6) is an anti-methicillin-resistant Staphylococcus aureus (MRSA) agent with a MIC of 97 μg/mL and a MBC of 781.25 μg/mL. Anti-MRSA agent 31 has a potent antibacterial activity and a strong Binding Protein 2a (PBP2a) inhibitory activity .
|
-
- HY-N1347
-
|
3,3',4',5',7-Pentahydroxyflavone
|
Fungal
HIV Integrase
Bacterial
|
Infection
|
|
Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .
|
-
- HY-N12669
-
-
- HY-W167979
-
|
|
Fungal
|
Others
Cancer
|
|
3-Amino-1,2,4-triazin-5(2H)-one is an organic compound belonging to the triazine family. 3-Amino-1,2, 4-Triazin-5 (2H)-one and its derivatives may have a variety of biological activities, such as antibacterial, antifungal, antiviral, or antitumor but the specific activity depends on its chemical structure and functional groups. 3-Amino-1,2, 4-Triazin-5 (2H)-one is a lead compound with a wide range of applications .
|
-
- HY-B0919
-
|
CI-337; O-Diazoacetyl-L-serine; P-165
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
|
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection .
|
-
- HY-N2381R
-
|
|
NF-κB
Reference Standards
Parasite
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Menthone (Standard) is the analytical standard of Menthone. This product is intended for research and analytical applications. Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis .
|
-
- HY-111278R
-
-
- HY-139805A
-
|
|
Bacterial
Antibiotic
|
Cancer
|
|
Ticarcillin monosodium is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin monosodium is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin monosodium can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research .
|
-
- HY-N10561
-
|
|
Bacterial
|
Infection
|
|
Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
|
-
- HY-N1677
-
|
|
Bacterial
Parasite
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
2,6-Dimethoxy-1,4-benzoquinone, a natural phytochemical, is a known haustorial inducing factor. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimalaria effects .
|
-
- HY-N7112
-
|
Kitasamycin
|
Bacterial
Antibiotic
|
Infection
|
|
Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .
|
-
- HY-N0565A
-
|
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
|
Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .
|
-
- HY-155282
-
-
- HY-121793
-
|
(-)-Roemerine
|
Endogenous Metabolite
5-HT Receptor
mGluR
iGluR
Bacterial
Antibiotic
|
Infection
Neurological Disease
Cancer
|
|
Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases .
|
-
- HY-149925
-
|
|
Bacterial
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
|
Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor .
|
-
- HY-B0159A
-
|
Q-35 dihydrate
|
Bacterial
Antibiotic
|
Infection
|
|
Balofloxacin dihydrate (Q-35 dihydrate) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin dihydrate can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-123087
-
|
N-(3-oxodecanoyl)-homoserine lactone
|
Bacterial
|
Infection
|
|
N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone (N-(3-oxodecanoyl)-homoserine lactone) is a member of N-Acyl homoserine lactone (AHL) from V. alginolyticus strains. N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone is used for biofilm formation and has antibacterial activity .
|
-
- HY-130323
-
|
|
Bacterial
|
Infection
|
|
13-HPOT, a linolenic fatty acid hydroperoxide, is an antibacterial agent. 13-HPOT has a strong dose response effect on three plant pathogen gram negative bacteria: Pectobacterium carotovorum, Pseudomonas syringae and Xanthomonas translucens. 13-HPOT can interact with the lipid representative of the inner bacterial plasma membrane .
|
-
- HY-N10560
-
|
|
Bacterial
|
Infection
|
|
Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
|
-
- HY-149734
-
|
|
Bacterial
|
Infection
|
|
MA220607 is an antibacterial agent with low hemolytic toxicity and a dual-target mechanism of action (MOA). MA220607 promotes FtsZ protein polymerization, also increases the permeability of bacterial membranes and inhibits biofilm formation. The resistance rate of MA220607 is low, and the MICs against Gram-positive bacteria and Gram-negative bacteria are Table 0.062-2 μg/mL and 0.5-4 μg/mL, respectively) .
|
-
- HY-161279
-
|
|
Bacterial
Lactate Dehydrogenase
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating lactate dehydrogenase and promote the accumulation of reactive oxygen species to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections .
|
-
- HY-B1802B
-
|
A-61827 hydrochloride
|
Antibiotic
Bacterial
|
Infection
|
|
Tosufloxacin (A-61827) hydrochloride is an orally active fluoroquinolone antibiotic. Tosufloxacin hydrochloride shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-B1802C
-
|
A-61827 tosylate
|
Antibiotic
Bacterial
|
Infection
|
|
Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-B1802A
-
|
A-61827 tosylate hydrate; T-3262
|
Bacterial
Antibiotic
|
Infection
|
|
Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-W799435
-
|
A-61827 hydrate
|
Antibiotic
Bacterial
|
Infection
|
|
Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-B1802
-
|
A-61827
|
Antibiotic
Bacterial
|
Infection
|
|
Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-145307
-
DATPT
1 Publications Verification
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
DATPT is a 12WLVSKF17 peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis .
|
-
- HY-N0565B
-
|
Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031
|
Antibiotic
MMP
Bacterial
Parasite
|
Infection
Cancer
|
|
Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .
|
-
- HY-N0565AR
-
|
|
Reference Standards
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
|
Doxycycline (hydrochloride) (Standard) is the analytical standard of Doxycycline (hydrochloride). This product is intended for research and analytical applications. Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity [4] .
|
-
- HY-N0565R
-
|
|
Reference Standards
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
|
Doxycycline (Standard) is the analytical standard of Doxycycline. This product is intended for research and analytical applications. Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity [4] .
|
-
- HY-P2853
-
-
- HY-17395
-
|
TDT 067 hydrochloride
|
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N2922
-
|
|
Amyloid-β
NF-κB
|
Neurological Disease
Inflammation/Immunology
|
|
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound .
|
-
- HY-17395A
-
|
TDT 067
|
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P10515
-
|
|
Bacterial
Fungal
|
Infection
Cancer
|
|
AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .
|
-
- HY-N0565C
-
|
|
MMP
Bacterial
Antibiotic
Parasite
|
Infection
Cancer
|
|
Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline calcium can be used to construct gene expression regulation models .
|
-
- HY-126114R
-
|
|
COX
Interleukin Related
Bacterial
Fungal
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .
|
-
- HY-134635R
-
|
|
Bacterial
Fungal
HIV
|
Infection
Neurological Disease
Cancer
|
|
Dehydrozingerone (Standard) is the analytical standard of Dehydrozingerone. This product is intended for research and analytical applications. Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC50 value of 0.50 mM .
|
-
- HY-122503
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Guamecycline is a semisynthetic tetracycline. The antibacterial spectrum and antibacterial activity are the same as Tetracycline .
|
-
- HY-N0662
-
-
- HY-B1595
-
|
CS 1170
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cefmetazole (CS 1170) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative and anaerobic bacteria. Cefmetazole binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-B1257
-
|
Sodium cefmetazole
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-B1210R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Pipemidic acid (Standard) is the analytical standard of Pipemidic acid. This product is intended for research and analytical applications. Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-17395B
-
|
TDT 067 lactate
|
Antibiotic
Fungal
Bacterial
|
Infection
|
|
Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine (lactate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-U00225
-
|
|
Bacterial
|
Infection
|
|
A7132 is an antibacterial agent. A7132 possess broad and potent antibacterial activity.
|
-
- HY-N0565BR
-
|
Doxycycline hydrochloride hemiethanolate hemihydrate (Standard); WC2031 (Standard)
|
Reference Standards
Antibiotic
MMP
Bacterial
Parasite
|
Infection
Cancer
|
|
Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate. This product is intended for research and analytical applications. Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity .
|
-
- HY-N1347R
-
|
3,3',4',5',7-Pentahydroxyflavone (Standard)
|
Reference Standards
Fungal
HIV Integrase
Bacterial
|
Infection
|
|
Robinetin (Standard) is the analytical standard of Robinetin. This product is intended for research and analytical applications. Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation .
|
-
- HY-D0896
-
|
ANSA; 8-Anilino-1-naphthalenesulfonic acid
|
Bacterial
|
Infection
|
|
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (Ki=2.09×10 6 M -1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development .
|
-
- HY-N0055R
-
|
3-O-Caffeoylquinic acid (Standard); Heriguard (Standard); NSC-407296 (Standard)
|
Reference Standards
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species (ROS)
Bacterial
Influenza Virus
Endogenous Metabolite
|
Infection
Inflammation/Immunology
Cancer
|
|
Chlorogenic acid (Standard) is the analytical standard of Chlorogenic acid. This product is intended for research and analytical applications. Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
|
-
- HY-119675
-
|
|
Bacterial
|
Infection
Cancer
|
|
Albonoursin, a microbial secondary metabolite, is an antibacterial peptide. Albonoursin displays antibacterial and antitumor activities .
|
-
- HY-19147
-
|
|
Bacterial
|
Infection
|
|
BMY-43748 is a promising antibacterial agent, exhibiting great in vitro and in vivo antibacterial activity.
|
-
- HY-N11706
-
|
(+)-β-Cedrene
|
Fungal
|
Infection
Inflammation/Immunology
|
|
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM .
|
-
- HY-143334
-
|
|
Fungal
|
Infection
|
|
Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability .
|
-
- HY-B0159R
-
|
Q-35 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Balofloxacin (Standard) is the analytical standard of Balofloxacin. This product is intended for research and analytical applications. Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections .
|
-
- HY-N3831
-
|
|
Bacterial
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation .
|
-
- HY-33040
-
|
|
Bacterial
|
Infection
|
|
2,2',4'-Trichloroacetophenone (Compound 3) is an α-haloacetophenone analogue. 2,2',4'-Trichloroacetophenone exhibits good antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 0.54 and 2.02 mg/L, respectively. 2,2',4'-Trichloroacetophenone can be used for antibacteria study .
|
-
- HY-105084
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity .
|
-
- HY-N0711
-
|
Cymophenol
|
Notch
Apoptosis
Fungal
Endogenous Metabolite
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
|
-
- HY-B1907A
-
|
Rifamycin SV
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Inflammation/Immunology
|
|
Rifamycin (Rifamycin SV) is an orally active ansamycin antibiotic. Rifamycin inhibits DNA-dependent RNA synthesis. Rifamycin has antibacterial activity against Mycobacterium tuberculosis. Rifamycin interferes with hepatic bile acid metabolism. Rifamycin has anti-inflammatory effects. Rifamycin can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
|
-
- HY-17395R
-
|
TDT 067 hydrochloride (Standard)
|
Reference Standards
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B1907
-
|
Rifamycin SV sodium
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
Inflammation/Immunology
|
|
Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
|
-
- HY-17395AR
-
|
TDT 067 (Standard)
|
Reference Standards
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-125604
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases .
|
-
- HY-14865B
-
|
PTK 0796 tosylate; Amadacycline tosylate
|
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-14865C
-
|
PTK0796 hydrochloride; Amadacycline hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-14865
-
|
PTK 0796; Amadacycline
|
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-14865A
-
|
PTK 0796 mesylate; Amadacycline mesylate
|
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (PTK 0796) mesylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline mesylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline mesylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline mesylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-176234
-
-
- HY-W018555R
-
|
|
Reference Standards
Endogenous Metabolite
Bacterial
|
Infection
Neurological Disease
|
|
D-Cysteine (Standard) is the analytical standard of D-Cysteine. This product is intended for research and analytical applications. D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day[1][2][3][4].
|
-
- HY-P5712
-
|
Gramicidin soviet
|
Antibiotic
Bacterial
Na+/K+ ATPase
|
Infection
|
|
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
|
-
- HY-N8971
-
|
16α-Hydroxybauerenol
|
Bacterial
|
Infection
|
|
Bauer-7-ene-3β,16α-diol, a triterpenoid, is a natural product that can be isolated from dried flower buds of Tussilago farfara L. or Petasites tricholobus (Compositae). Bauer-7-ene-3β,16α-diol shows medium antibacterial activity against E. coli .
|
-
- HY-P1751
-
|
|
Bacterial
|
Infection
|
|
Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .
|
-
- HY-N2896
-
|
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Arjunolic acid is a saponin isolated from Cyclocarya paliurus and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species .
|
-
- HY-N6962
-
|
|
TRP Channel
COX
Bacterial
|
Infection
Neurological Disease
Metabolic Disease
|
|
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC50 values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice .
|
-
- HY-143236
-
|
|
Bacterial
Fungal
|
Infection
|
|
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249 .
|
-
- HY-N9386
-
|
Eugeniin
|
Bacterial
Antibiotic
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases .
|
-
- HY-W076794
-
|
|
Bacterial
|
Infection
|
|
3-Bromo-1H-pyrrole-2,5-dione (compound 2c) is a 3-substituted pyrrole-2,5-dione compound with antibacterial activity. 3-Bromo-1H-pyrrole-2,5-dione inhibits pathogenic strains of S. aureus ATCC 25923, E. coli ATCC 25922, P. aeruginosa ATCC 27853, with MIC values of 32 μg/mL, 32 μg/mL, and 64 μg/mL, respectively .
|
-
- HY-N12096
-
|
α-Acetylsalazinic acid
|
Bacterial
|
Infection
|
|
Galbinic acid (α-Acetylsalazinic acid), a lichen acid, shows antibacterial activities against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus (MICs=62.5, 62.5, 250 μg/ml, respectively). Galbinic acid inhibits the Gram-negative bacterium E. coli (MIC=125 μg/ml) .
|
-
- HY-117843
-
-
- HY-147522
-
|
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells .
|
-
- HY-164793
-
|
|
TGF-β Receptor
Cytochrome P450
Bacterial
|
Infection
|
|
TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis .
|
-
- HY-W473763
-
|
|
Antibiotic
Fungal
|
Infection
|
|
3-Methoxy-2, 5-toluquinone is an antibacterial agent with moderate anti-bacterial and fungal effects .
|
-
- HY-N11169
-
|
|
Bacterial
|
Infection
|
|
Apigravin is a potent antibacterial agent. Apigravin shows antibacterial activity against Bacillus subtilis with a MIC value of 61 μM .
|
-
- HY-126461
-
|
|
Bacterial
Fungal
|
Infection
|
|
Salazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium .
|
-
- HY-N9448
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula .
|
-
- HY-163463
-
|
|
Phosphatase
Fungal
HIV
Bacterial
|
Infection
Metabolic Disease
|
|
PTP1B-IN-25 (Compound 19) is a PTP1B inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC50 values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus (MRSA) respectively .
|
-
- HY-B1257R
-
|
Sodium cefmetazole (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Cefmetazole (sodium) (Standard) is the analytical standard of Cefmetazole (sodium). This product is intended for research and analytical applications. Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .
|
-
- HY-130337
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Teicoplanin A2-2 is a glycopeptide antibiotic. Teicoplanin A2-2 exhibits antibacterial activity, particularly against coagulase-negative staphylococci (CNS). Teicoplanin A2-2 inhibits bacterial cell wall synthesis by competitively binding to the terminal D-Ala-D-Ala peptide bonds in the cell wall synthesis process, leading to bacterial death. Teicoplanin A2-2 can be used for research into bacterial resistance mechanisms and the development of new antibiotics .
|
-
- HY-N0662R
-
-
- HY-W040265
-
|
N-Phenylanthranilic acid
|
Chloride Channel
|
Inflammation/Immunology
|
|
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent - .
|
-
- HY-B1802CR
-
|
A-61827 tosylate (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Tosufloxacin (tosylate) (Standard) is the analytical standard of Tosufloxacin (tosylate). This product is intended for research and analytical applications. Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria .
|
-
- HY-115440
-
|
REP-3123 dihydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
CRS3123 (REP-3123) dihydrochloride, a fully synthetic antibacterial agent, potently inhibits methionyl-tRNA synthetase (MetRS) of Clostridioides difficile, inhibiting Clostridioides difficile toxin production and spore formation. CRS3123 dihydrochloride is an oral agent for the research of Clostridioides difficile infection (CDI) .
|
-
- HY-N7503
-
|
|
Histamine Receptor
Calcium Channel
Calmodulin
|
Infection
Metabolic Disease
Cancer
|
|
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .
|
-
- HY-143415
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains .
|
-
- HY-16672
-
|
|
Bacterial
|
Infection
|
|
AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens.
|
-
- HY-B1802AR
-
|
A-61827 tosylate hydrate (Standard); T-3262 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Tosufloxacin (tosylate hydrate) (Standard) is the analytical standard of Tosufloxacin (tosylate hydrate). This product is intended for research and analytical applications. Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].
|
-
- HY-N0625A
-
|
|
PPAR
Keap1-Nrf2
Toll-like Receptor (TLR)
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury .
|
-
- HY-N0711R
-
|
Cymophenol (Standard)
|
Reference Standards
Notch
Apoptosis
Fungal
Endogenous Metabolite
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
|
-
- HY-117736
-
|
|
Penicillin-binding protein (PBP)
Bacterial
|
Infection
Inflammation/Immunology
|
|
Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections .
|
-
- HY-N1957
-
|
γ-Mangostin
|
5-HT Receptor
COX
Transthyretin (TTR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
|
-
- HY-14865R
-
|
PTK 0796 (Standard); Amadacycline (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (Standard) is the analytical standard of Omadacycline. This product is intended for research and analytical applications. Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-14865CR
-
|
PTK0796 hydrochloride (Standard); Amadacycline hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (hydrochloride) (Standard) is the analytical standard of Omadacycline (hydrochloride). This product is intended for research and analytical applications. Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].
|
-
- HY-14865BR
-
|
PTK 0796 tosylate (Standard); Amadacycline tosylate (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Omadacycline (tosylate) (Standard) is the analytical standard of Omadacycline (tosylate). This product is intended for research and analytical applications. Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .
|
-
- HY-B1454
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Clindamycin palmitate hydrochloride is a hydrochloride salt of the ester of clindamycin and palmitic acid and it is an antibacterial agent. Clindamycin palmitate hydrochloride is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin .
|
-
- HY-123724
-
|
|
Others
|
Others
|
|
Ravidomycin is a compound with antibacterial and cytotoxic activities. New analogs have been isolated from microorganisms. These analogs differ in antibacterial selectivity compared with known compounds.
|
-
- HY-14456A
-
|
|
Bacterial
|
Infection
|
|
MAC13243, an antibacterial agent, is an inhibitor of bacterial lipoprotein targeting chaperone, LolA. MAC13243 is an antibacterial agent with Gram-negative selectivity .
|
-
- HY-158401
-
|
|
Bacterial
|
Infection
|
|
Antibiofilm agent-7 (Compound 9) exhibits potent antibiofilm activity with IC50 of 60, 133.32, and 19.67 µg/mL against S. aureus, E. coli, and methicillin-resistant S. aureus (MRSA), respectively. Antibiofilm agent-7 has antibacterial activity for S. aureus, E. coli, C. albicans, and MRSA, with MIC values of 4.88, 78.13, 9.77 and 39.06 µg/mL, respectively .
|
-
- HY-NP192
-
|
|
Reactive Oxygen Species (ROS)
Bacterial
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Sericin is a type of spherical protein that can be isolated from silk cocoons. Sericin is a cognitive enhancer and pain reliever. Sericin is a fetal bovine serum- or DMSO-replacing cryoprotectant agent. Sericin reduces oxidative stress and reactive oxygen species (ROS). Sericin can repair wounds by producing collagen. Sericin has antioxidant, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, skin moisturizer, wound healing, antibacterial, antimicrobial, and anti-tumor protector .
|
-
- HY-N0930B
-
|
|
AMPK
Bacterial
|
Infection
Metabolic Disease
|
|
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .
|
-
- HY-B0512A
-
-
- HY-P4327
-
|
|
Bacterial
|
Infection
|
|
Hispidalin is a novel antimicrobial peptide with broad and efficient antibacterial activity against various bacterial and fungal pathogens, and can be used as an antibacterial agent and food preservative .
|
-
- HY-W726164
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Gentamicin A is an antibiotic with good antibacterial activity to Gram-positive bacteria and negative bacteria. Gentamicin A has antibacterial activity against most methicillin-sensitive staphylococcus .
|
-
- HY-173163
-
|
|
Bacterial
|
Infection
|
|
(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) (Compound 4a) is a Gram-negative outer membrane permeabilizer with synergistic antibacterial activity through the blockage on LptA/LptC interaction via targeting Met47 in LptA. (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) potentiates pol B against both wild-typed and MDR A. baumannii and E. coli strains. (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) can be used as antibiotic adjuvants against MDR Gram-negative bacteria .
|
-
- HY-123175
-
|
|
Bacterial
|
Others
|
|
Chinfloxacin is a compound with antibacterial activity. It is active against a variety of clinical isolates in vitro. Its antibacterial activity is similar to that of moxifloxacin, and it has a bactericidal effect in a concentration-dependent manner.
|
-
- HY-147241
-
-
- HY-B0333
-
-
- HY-N14845
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Napsamycin A is an antibiotic. Napsamycin A has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria .
|
-
- HY-117742
-
|
|
Bacterial
|
Others
|
|
DA-7867 is an antibacterial compound with activity against a wide range of bacteria, including drug-resistant bacteria. DA-7867 shows promising antibacterial activity against some clinically important pathogens, including drug-resistant bacteria. It is an amide analog of Tedizolid, reflecting the potential use of tetrazoles in the development of new antibacterial agents.
|
-
- HY-170519
-
|
|
Bacterial
|
Infection
|
|
K13787 is an acetohydroxyacid synthase (AHAS) inhibitor with antibacterial activity. K13787 has antibacterial activity against a variety of nontuberculous mycobacteria (NTM) and clarithromycin (CLR) resistant strains .
|
-
- HY-N14985
-
|
|
Fungal
Bacterial
|
Infection
|
|
Dictyopanine A is found in the strain of Dictylpanus sp. Hki 0181. The antibacterial spectrum is narrow, and it has moderate antibacterial activity only against some filamentous fungi and Gram-positive bacteria .
|
-
- HY-122057
-
|
|
Others
|
Others
|
|
Bisdionin F is a compound with the ability to restore the antibacterial function of macrophages, which can block the arginase activity induced by Candida albicans and restore the nitric oxide production and antibacterial function of macrophages.
|
-
- HY-162898
-
|
|
Bacterial
|
Infection
|
|
Anti-virulence factor-IN-1 (Compound 4S) is a bacterial virulence factor inhibitor by interfering with the bacterial infection process. Anti-virulence factor-IN-1 exhibits an antibacterial activity against Xoo in vitro with an EC50 value of 0.28 µg/mL. Anti-virulence factor-IN-1 can be used to effectively manage rice bacterial leaf blight in vivo. Anti-virulence factor-IN-1 is promising for research of plant bacterial disease .
|
-
- HY-Z0478
-
|
(S)-(-)-Limonene
|
Bacterial
Antibiotic
CaMK
|
Infection
Cardiovascular Disease
Metabolic Disease
|
|
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca 2+) and Ca 2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .
|
-
- HY-N1957R
-
|
γ-Mangostin (Standard)
|
Reference Standards
5-HT Receptor
COX
Transthyretin (TTR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
|
-
- HY-100289
-
-
- HY-105932
-
|
Erythromycin A 9-methoxime; Wy 48314
|
Bacterial
Antibiotic
|
Infection
|
|
Lexithromycin is an erythromycin A derivative, with antibacterial activity.
|
-
- HY-N15101
-
-
- HY-122030
-
-
- HY-N15395
-
-
- HY-117170
-
-
- HY-N14851
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Napsamycin C is an antibiotic. Napsamycin C has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria .
|
-
- HY-N14850
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Napsamycin B is an antibiotic. Napsamycin B has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria .
|
-
- HY-N14852
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Napsamycin D is an antibiotic. Napsamycin D has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria .
|
-
- HY-144300
-
|
TNP-2198
|
Bacterial
|
Infection
|
|
Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .
|
-
- HY-121610
-
|
|
Bacterial
Antibiotic
|
Others
|
|
FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.
|
-
- HY-N7515
-
|
2',4',6'-Trihydroxychalcone
|
Bacterial
AMPK
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes .
|
-
- HY-B0942
-
|
|
nAChR
Bacterial
Apoptosis
Caspase
|
Infection
Neurological Disease
Cancer
|
|
Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo .
|
-
- HY-148690
-
|
|
Bacterial
Fungal
|
Infection
|
|
L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections .
|
-
- HY-130753
-
|
|
Bacterial
|
Infection
|
|
JM 1397 is an antibacterial agent that exhibits potent antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration (MIC90) of 1 μg/mL . .
|
-
- HY-N0354
-
|
|
Virus Protease
Topoisomerase
Apoptosis
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .
|
-
- HY-143414
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .
|
-
- HY-N0625AR
-
|
|
Reference Standards
PPAR
Keap1-Nrf2
Toll-like Receptor (TLR)
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Alpinetin (Standard) is the analytical standard of Alpinetin. This product is intended for research and analytical applications. Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury .
|
-
- HY-16980
-
-
- HY-100262
-
|
|
Bacterial
|
Infection
|
|
Sulfasymazine is a sulfonamide agent and displays antibacterial properties.
|
-
- HY-B1407
-
|
N4-Phthalylsulfathiazole
|
Bacterial
Antibiotic
|
Others
|
|
Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.
|
-
- HY-N15083
-
-
- HY-N15266
-
-
- HY-N13946
-
-
- HY-129124
-
-
- HY-W104195A
-
-
- HY-N14404
-
-
- HY-N14598
-
-
- HY-B0512
-
-
- HY-N15021
-
-
- HY-119626
-
-
- HY-N13966
-
-
- HY-U00120
-
|
|
Bacterial
|
Infection
|
|
Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity.
|
-
- HY-P1063
-
-
- HY-121978
-
|
|
Fungal
|
Infection
|
|
Laxifloran exhibits both antibacterial and antifungal properties.
|
-
- HY-127156
-
|
Anthelmycin
|
Bacterial
|
Infection
|
|
Hikizimycin is a potent anthelmintic and antibacterial natural product.
|
-
- HY-114812
-
|
|
Bacterial
|
Infection
|
|
Anthrarobin is an antipsoriatic agent with antibacterial and oxidative potential.
|
-
- HY-N14815
-
-
- HY-N0941
-
|
β-Mangostin
|
Bacterial
Parasite
Apoptosis
|
Infection
Cancer
|
|
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .
|
-
- HY-129487
-
|
|
Bacterial
|
Infection
|
|
(E/Z)-MC4 is an enantiomer of the antibacterial agent MC4, which has antibacterial activity against a group of Staphylococcus aureus strains including MRSA, and has no significant toxicity to mammalian cells .
|
-
- HY-N2789
-
|
|
Bacterial
Fungal
|
Infection
|
|
(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata . (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-125042
-
|
|
Bacterial
|
Infection
|
|
Sarothralin G is an antibacterial compound isolated from Hypericum japonicum Thunb. (Japanese spurfle). The structure of Sarothralin G contains phenolic and aromatic acid moieties and shows excellent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Nocardia spp., which is stronger than Sarothralen A, B and Saroaspidin A, B, C. Sarothralin G exhibits significant antibacterial potential.
|
-
- HY-B1263
-
|
|
Bacterial
Fungal
|
Infection
Neurological Disease
|
|
Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry .
|
-
- HY-P10694
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
IDR-HH2 is an immunomodulatory peptide with the ability to modulate the host cytokine/chemokine environment. IDR-HH2 can promote the adhesion of monocytes and THP-1 cells to fibronectin. Additionally, IDR-HH2 possesses antibacterial activity, inhibiting the activity of both P. aeruginosa and S. aureus with MIC values of 75 µg/mL and 38 µg/mL, respectively .
|
-
- HY-119963A
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
trans-β-terpineol, a monoterpenoid compound, can be isolated from the leaves of Schinus terebinthifolius. Terpineol has antioxidant and antibacterial activity. trans-β-terpineol is a bioactive compound that plays an antibacterial role in Schinus terebinthifolius .
|
-
- HY-N6613
-
|
Galacturonic acid polymer
|
Others
|
Infection
Inflammation/Immunology
|
|
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity .
|
-
- HY-133056
-
-
- HY-127075
-
-
- HY-N13947
-
-
- HY-N14874
-
-
- HY-N13954
-
-
- HY-N13953
-
-
- HY-N13968
-
-
- HY-N13967
-
-
- HY-P1063A
-
-
- HY-N13882
-
|
|
Bacterial
|
Infection
|
|
Aldgamycin F is a Aldgamycin derivative with antibacterial activities .
|
-
- HY-N14306
-
|
|
Bacterial
|
Infection
|
|
Aspersitin is a metabolite of Aspergillus parasiticus with antibacterial activity .
|
-
- HY-N14067
-
-
- HY-N14992
-
|
|
Bacterial
|
Infection
|
|
Melleolide L is a sesquiterpene aromatic acid ester with a weak antibacterial activity .
|
-
- HY-N7216
-
-
- HY-N14788
-
-
- HY-W017767
-
-
- HY-116639
-
|
|
Bacterial
|
Infection
Cancer
|
|
Javanicin is an antibacterial agent with certain antibacterial activity against pathogenic bacteria such as Bacillus megaterium, Staphylococcus aureus, Salmonella typhi, and Escherichia coli. Javanicin has weak cytotoxicity against the human lung cancer cell line .
|
-
- HY-N0540
-
|
Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside
|
Influenza Virus
DNA/RNA Synthesis
Apoptosis
Parasite
Bacterial
Fungal
|
Infection
Cardiovascular Disease
Cancer
|
|
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
|
-
- HY-B0712B
-
|
Ro 13-9904
|
Antibiotic
GSK-3
Bacterial
Aurora Kinase
|
Infection
Inflammation/Immunology
Cancer
|
|
Ceftriaxone sodium salt (Ro 13-9904) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium salt is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium salt is an inhibitor of Aurora B. Ceftriaxone sodium salt has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium salt can be used in the study of bacterial infections and meningitis .
|
-
- HY-P1259
-
|
|
Proteasome
Bacterial
|
Inflammation/Immunology
|
|
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .
|
-
- HY-N12763
-
|
SNH
|
Bacterial
Renin
|
Inflammation/Immunology
|
|
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .
|
-
- HY-B1217
-
|
BNPD; BNPK
|
Bacterial
|
Infection
|
|
Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
|
-
- HY-N6746
-
|
NSC 186
|
Bacterial
Fungal
Endogenous Metabolite
Apoptosis
|
Infection
Neurological Disease
Cancer
|
|
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
|
-
- HY-105832
-
|
Phenbenicillin potassium; α-Phenoxybenzylpenicillin potassium
|
Bacterial
|
Infection
|
|
Fenbenicillin (Phenbenicillin) potassium is semi-synthetic penicillin with antibacterial effecst .
|
-
- HY-N14150
-
-
- HY-U00389
-
|
KPI-10 free base
|
Bacterial
|
Infection
|
|
WQ3810 is an orally active fluoroquinolone, with potent antibacterial activities.
|
-
- HY-169507
-
-
- HY-123036
-
|
|
Bacterial
|
Infection
|
|
Renierone is an antibacterial metabolite found in the sponge Reniera sp. .
|
-
- HY-N15089
-
|
|
Bacterial
|
Infection
|
|
Melleolide M is a sesquiterpene aromatic acid ester with a weak antibacterial activity .
|
-
- HY-U00221
-
|
Win49375
|
Bacterial
|
Infection
|
|
Amifloxacin (Win49375) is a synthetic antibacterial agent of the quinolone class.
|
-
- HY-N5202
-
-
- HY-N13993
-
-
- HY-P1259A
-
|
|
Proteasome
Bacterial
|
Inflammation/Immunology
|
|
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .
|
-
- HY-170386
-
|
|
Bacterial
|
Infection
|
|
TXY541 is an orally active antibacterial agent that can be converted to PC190723 (HY-146331) under physiological conditions. TXY541 has good antibacterial effect against Staphylococcus aureus and low toxicity to mammalian cells .
|
-
- HY-W004294
-
-
- HY-161018
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
CF3–K11 is a stable antibiotic with antibacterial activity. CF3–K11 has strong antibacterial activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA).
|
-
- HY-117108
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Nocardicin A is a beta-lactam antibiotic with selective antibacterial activity. Nocardicin A has moderate antibacterial activity against a broad spectrum of Gram-negative bacteria including Proteus and Pseudomonas; it has no inhibitory effect on Staphylococcus, Mycobacterium, fungi, and yeast .
|
-
- HY-162761
-
|
|
Bacterial
COX
|
Inflammation/Immunology
|
|
COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC50 values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states .
|
-
- HY-169331
-
|
|
Bacterial
|
Infection
|
|
H2S scavenger 1 triflate (Compound 7b) is a H2S-depletion agent, and shows selectivity over glutathione. H2S scavenger 1 triflate disrupts the bacterial biofilm formation. H2S scavenger 1 triflate sensitizes S. aureus to Gentamicin (HY-A0276A) or photosensitizer via H2S depletion .
|
-
- HY-147274
-
-
- HY-B1454R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Clindamycin palmitate (hydrochloride) (Standard) is the analytical standard of Clindamycin palmitate (hydrochloride). This product is intended for research and analytical applications. Clindamycin palmitate hydrochloride is a hydrochloride salt of the ester of clindamycin and palmitic acid and it is an antibacterial agent. Clindamycin palmitate hydrochloride is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin .
|
-
- HY-117204
-
|
|
Antibiotic
|
Infection
|
|
AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain was isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria. The discovery of AA-57 provides new possibilities for antibacterial therapy.
|
-
- HY-N14045
-
|
|
Bacterial
|
Infection
|
|
Celesticetin is an antibacterial agent that can inhibit the growth of S. acidocaldarius .
|
-
- HY-129691
-
|
|
Bacterial
|
Infection
|
|
Ro 14-1761 is a third-generation cephalosporin with antibacterial activity .
|
-
- HY-120583
-
|
|
Bacterial
|
Infection
|
|
(Rac)-LY 255262 is a pyrazolidinone-derivative that has antibacterial activity .
|
-
- HY-112657
-
|
|
Bacterial
|
Infection
|
|
Xanthorrhizol, isolated from Curcuma xanthorrhiza Roxb, is a potential antibacterial agent.
|
-
- HY-N2061
-
|
|
Bacterial
|
Infection
|
|
Lindenenol is isolated from Radix linderae, with antioxidant and antibacterial activities .
|
-
- HY-N8206
-
-
- HY-B0210
-
-
- HY-159843
-
-
- HY-136802
-
|
|
Bacterial
|
Infection
|
|
LolCDE-IN-3 (compound 8) is a LolCDE inhibitor with antibacterial activity.
|
-
- HY-16980A
-
|
TP-434 dihydrochloride; TP-434-046
|
Beta-lactamase
Bacterial
|
Infection
|
|
Eravacycline dihydrochloride (TP-434 dihydrochloride) is a potent and broad-spectrum antibacterial agent.
|
-
- HY-N14151
-
-
- HY-172250
-
-
- HY-W740165
-
|
|
Antibiotic
Drug Metabolite
|
Infection
|
|
Desmethyl Levofloxacin hydrochloride is an antibacterial agent with broad-spectrum antibacterial activity against a variety of pathogens. Desmethyl Levofloxacin hydrochloride effectively fights bacterial infections by inhibiting bacterial DNA synthesis. Studies on Desmethyl Levofloxacin hydrochloride have shown that it has potential in inhibiting respiratory infections .
|
-
- HY-N14518
-
|
|
Bacterial
|
Infection
|
|
Pacidamycin 6 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 6 also has effect on a few strains of bacteria such as suppurative staphylococcus and Escherichia coli. Serum can reduce its antibacterial activity, pH also affects its antibacterial activity .
|
-
- HY-N14517
-
|
|
Bacterial
|
Infection
|
|
Pacidamycin 4 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 4 also has effect on a few strains of bacteria such as suppurative staphylococcus and Escherichia coli. Serum can reduce its antibacterial activity, pH also affects its antibacterial activity .
|
-
- HY-N14519
-
|
|
Bacterial
|
Infection
|
|
Pacidamycin 7 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 7 also has effect on a few strains of bacteria such as suppurative staphylococcus and Escherichia coli. Serum can reduce its antibacterial activity, pH also affects its antibacterial activity .
|
-
- HY-N0656
-
|
|
Bacterial
DNA/RNA Synthesis
Nuclear Factor of activated T Cells (NFAT)
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .
|
-
- HY-N14263
-
|
|
Bacterial
|
Infection
|
|
Kirrothricin has antibacterial action, but no activity to subtilis, E.coli and fungi .
|
-
- HY-N3056
-
-
- HY-19081
-
-
- HY-B0210C
-
-
- HY-122930
-
-
- HY-N14545
-
-
- HY-P5719
-
|
|
Bacterial
|
Infection
|
|
Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .
|
-
- HY-127000
-
|
|
Bacterial
Fungal
|
Infection
|
|
Julifloricine is an alkaloid from Prosopis juliflora. Julifloricine has antibacterial activity .
|
-
- HY-N0129
-
|
|
Bacterial
|
Infection
|
|
Sclareolide is isolated from the flower of Perilla frutescens with antibacterial and cytotoxic activities .
|
-
- HY-130402B
-
|
|
Parasite
|
Infection
|
|
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .
|
-
- HY-N14967
-
|
|
Bacterial
|
Infection
|
|
Epicillin is found in the strain of Semisynthetic broad-spectrum penicillin with antibacterial activities .
|
-
- HY-A0130
-
|
Sulfametopyrazine; AS-18908
|
Parasite
Bacterial
Antibiotic
|
Infection
|
|
Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial.
|
-
- HY-117870
-
-
- HY-N6746R
-
|
NSC 186 (Standard)
|
Reference Standards
Bacterial
Fungal
Endogenous Metabolite
Apoptosis
|
Infection
Neurological Disease
Cancer
|
|
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
|
-
- HY-N0941R
-
|
β-Mangostin (Standard)
|
Reference Standards
Bacterial
Parasite
Apoptosis
|
Infection
Cancer
|
|
beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .
|
-
- HY-W107077
-
|
|
Bacterial
|
Infection
|
|
INF55 is a NoA multidrug resistance pump inhibitor with the activity of inhibiting the NoA pump. The heterocomplex formed by INF55 combined with berberine shows the potential to combat the resistance of bacterial compounds. INF55 can enhance the antibacterial activity of berberine by reducing its efflux. The structural variants of INF55 can show different NoA inhibitory activities, thereby affecting the antibacterial effect of its corresponding heterocomplexes. Different derivatives of INF55 show similar activity in terms of antibacterial dose and effectiveness .
|
-
- HY-N2301
-
|
Drosophilin B; Mutilin 14-glycolate
|
Antibiotic
Bacterial
|
Infection
|
|
Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis .
|
-
- HY-169811
-
-
- HY-B0333S
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamethizole-d4 is the deuterium labeled Sulfamethizole. Sulfamethizole is a sulfathiazole antibacterial agent.
|
-
- HY-N13988
-
|
|
Parasite
|
Infection
|
|
Abierixin has good anti-coccidial activity and weak antibacterial and ionophore activity .
|
-
- HY-P10907
-
|
|
Bacterial
|
Infection
|
|
Zaloganan exhibits board-spectrum antibacterial activity through disruption of bacterial membranes .
|
-
- HY-N4052A
-
|
|
Bacterial
|
Infection
|
|
(±)-Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .
|
-
- HY-N4052
-
|
|
Bacterial
|
Infection
|
|
Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .
|
-
- HY-N14308
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Aspiculamycin, a cytosine nucleoside, is an antibiotic. Aspiculamycin has a broad spectrum of antibacterial activity .
|
-
- HY-N5008
-
|
|
Bacterial
|
Infection
|
|
Macranthoside B, isolated from Flos Lonicerae, possesses anti-bacterial activity .
|
-
- HY-119280
-
-
- HY-N0540R
-
|
Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)
|
Apoptosis
DNA/RNA Synthesis
Parasite
Bacterial
Influenza Virus
Fungal
Reference Standards
|
Infection
Cancer
|
|
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
|
-
- HY-N2187
-
|
|
Bacterial
HIF/HIF Prolyl-Hydroxylase
PI3K
Apoptosis
|
Infection
Cardiovascular Disease
Cancer
|
|
Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL) .
|
-
- HY-B1217S
-
|
BNPD-d4; BNPK-d4
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Bronopol-d4 is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
|
-
- HY-151458
-
|
|
VEGFR
Bacterial
Dihydrofolate reductase (DHFR)
Fungal
|
Infection
Cancer
|
|
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .
|
-
- HY-P2317
-
|
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection .
|
-
- HY-126735
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC50 of 0.15 and 0.15 μg/mL .
|
-
- HY-B0454
-
-
- HY-N14168
-
|
|
Bacterial
|
Infection
|
|
Ashimycin A is a Streptomycin (HY-B1906) analogue with a broad-spectrum antibacterial activity .
|
-
- HY-N14690
-
|
|
Fungal
|
Infection
|
|
Piperazinomycin has anti-fungal, yeast, some mycobacterium effects, but no anti-bacterial effect .
|
-
- HY-106339
-
-
- HY-N14546
-
|
|
Bacterial
|
Infection
|
|
Oxirapentyn has anti-Gram-positive bacteria and Mycobacterium activity, but the antibacterial activity is weak .
|
-
- HY-N14187
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Aspergillic acid is an antibiotic found in Aspergillus flavus. Aspergillic acid has a broad spectrum of antibacterial activity .
|
-
- HY-128467
-
|
Sodium dehydroacetate
|
Bacterial
Fungal
|
Infection
|
|
Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity .
|
-
- HY-N12223
-
-
- HY-148294
-
|
|
Bacterial
Fungal
|
Infection
|
|
Monogalactosyl diglyceride is a antimicrobial. Monogalactosyl diglyceride has antibacterial activity and antifungal activity in vitro .
|
-
- HY-B0210A
-
|
CP 52640-2
|
Bacterial
Antibiotic
|
Infection
|
|
Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-121873
-
|
|
Bacterial
|
Infection
|
|
Lavendamycin is a quinolinedione that can be extracted from bacteria and has potent antibacterial and antitumor properties .
|
-
- HY-13573
-
-
- HY-N14996
-
|
|
Bacterial
|
Infection
|
|
6-Deoxyparomomycin is found in the strain of Streptomyces rimosus forma paromomycinus with antibacterial activity .
|
-
- HY-P10683
-
|
|
Bacterial
|
Infection
|
|
RAWVAWR-NH2 is a peptide derived from human lysozyme with antibacterial activity .
|
-
- HY-B0308
-
|
CI-978; AT-4140
|
Bacterial
Antibiotic
|
Infection
|
|
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .
|
-
- HY-B1119
-
|
|
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
|
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-B1217R
-
|
BNPD (Standard); BNPK (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
Bronopol (Standard) is the analytical standard of Bronopol. This product is intended for research and analytical applications. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
|
-
- HY-P10682
-
|
|
Bacterial
|
Infection
|
|
PuroA is a tryptophan-rich domain of Puroindoline a that exerts antibacterial activity through interaction with bacterial membranes .
|
-
- HY-N13930
-
|
|
Bacterial
|
Infection
|
|
Azicemicin A has weak antibacterial activity. Azicemicin A without any acute toxicity in the micesup>[1].
|
-
- HY-N14262
-
|
|
Bacterial
|
Infection
|
|
Kinamycin A has antibacterial and mycobacterial effects, but it has weak activity against Gram-negative bacteria .
|
-
- HY-N0080
-
|
Peucedanol methyl ether
|
Bacterial
Fungal
|
Infection
|
|
Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities .
|
-
- HY-N14995
-
-
- HY-N14170
-
|
|
Bacterial
|
Infection
|
|
Ashimycin B is a Streptomycin (HY-B1906) analogue with a broad-spectrum antibacterial activity .
|
-
- HY-163203
-
|
|
Bacterial
|
Infection
|
|
DDC18-8A is an amphiphilic dendrimer that exhibits high antibacterial and antibiofilm efficacy .
|
-
- HY-121620
-
-
- HY-132282
-
|
|
Bacterial
|
Infection
|
|
Thiamphenicol glycinate hydrochloride is a broad-spectrum antibacterial agent that can be used for respiratory tract infections research .
|
-
- HY-N10585
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Malacidin B is a macrocyclic lipopeptide antibiotic that shows antibacterial activity in a calcium-dependent manner .
|
-
- HY-W355141
-
|
|
Bacterial
|
Cancer
|
|
Isopulegol is one of the main components of ECO (Eucalyptus citriodora oil). ECO has antibacterial activity .
|
-
- HY-N14058
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Halymecin A is an antibiotic found in Marine microbes. Halymecin A had only weak antibacterial and fungal activity .
|
-
- HY-P1062
-
-
- HY-N14046
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Celesticetin B is an antibiotic. Celesticetin B is mainly antibacterial against Gram-positive microorganisms .
|
-
- HY-112324
-
|
|
Bacterial
|
Infection
|
|
Terizidone is an antibacterial agent, and shows bacteriostatic activity. Terizidone can be used in tuberculosis (TB) research .
|
-
- HY-111902
-
|
|
Bacterial
|
Infection
|
|
MCB-3681 is the antibacterial Oxaquin's active substance, active against gram-positive bacterium .
|
-
- HY-N2150
-
|
|
HDAC
DNA Methyltransferase
DNA/RNA Synthesis
Bacterial
Aminopeptidase
Farnesyl Transferase
PPAR
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
|
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .
|
-
- HY-101411
-
-
- HY-B0967
-
|
|
Bacterial
|
Infection
|
|
Phthalylsulfacetamide is a sulfa drug, after oral administration, slowly decompose in the intestine,and release sulfacetamide ,generating antibacterial effect.
|
-
- HY-122777
-
|
|
Bacterial
|
Infection
|
|
γ-Rubromycin is a natural product from Streptomyces. γ-Rubromycin has antibacterial activity .
|
-
- HY-N0337
-
-
- HY-N9682
-
|
|
Bacterial
|
Infection
|
|
Syringopicroside is a natural product that can be isolated from Syringa oblata Lindl. Syringopicroside has antibacterial activity .
|
-
- HY-10882
-
-
- HY-N14441
-
|
|
Fungal
|
Infection
|
|
Haliangicin A has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity .
|
-
- HY-B0356AS
-
|
Bay-09867-dd8 hydrochloride hydrate
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Ciprofloxacin-d8 (hydrochloride hydrate) is the deuterium labeled Ciprofloxacin hydrochloride monohydrate. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
|
-
- HY-132925
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
|
-
- HY-N14667
-
|
|
Bacterial
|
Infection
|
|
Cladospolide A is found in the strain of Cladosporium sp. FT-0012. Cladospolide A has little antibacterial activity .
|
-
- HY-W004296
-
-
- HY-N14438
-
|
|
Others
|
Cancer
|
|
Furaquinocin A can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .
|
-
- HY-B1414
-
-
- HY-P5714
-
|
|
Bacterial
|
Infection
|
|
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .
|
-
- HY-P1062A
-
-
- HY-B0453
-
-
- HY-N3536
-
-
- HY-129728
-
-
- HY-P4276
-
|
|
Bacterial
|
Infection
|
|
Arg-Trp is a dipeptide composed of arginine and tryptophan, and analogues of Arg-Trp-octyl ester show antibacterial activity .
|
-
- HY-B0356BS
-
|
Bay-09867-d8 hydrochloride monohydrate
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Ciprofloxacin-d8 (hydrochloride monohydrate) is the deuterium labeled Ciprofloxacin (hydrochloride monohydrate). Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
|
-
- HY-149699
-
-
- HY-122207
-
|
|
Antibiotic
|
Infection
|
|
Erythromycin A enol ether is an acidic degradation product of Erythromycin A (macrolide antibiotic) and has no antibacterial effect .
|
-
- HY-B1366A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Meclocycline is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgarisis .
|
-
- HY-125618
-
|
T-2636 D
|
Antibiotic
Bacterial
|
Infection
|
|
Lankacidinol A (T-2636 D) is an antibiotic, and shows antibacterial activity against Gram-positive bacteria .
|
-
- HY-W423191
-
|
4-O-α-D-Glucopyranosyl-D-gluconic acid
|
Biochemical Assay Reagents
|
Infection
|
|
Maltobionic acid is a naturally-derived polyhydroxy bionic acid. Maltobionic acid shows iron chelating ability, antibacterial potential and cytoprotection .
|
-
- HY-N3031
-
|
|
Bacterial
|
Infection
|
|
Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii. Grosvenorine exhibits good antibacterial and antioxidant activities .
|
-
- HY-P5724
-
|
|
Bacterial
|
Infection
|
|
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .
|
-
- HY-129197
-
|
|
Bacterial
|
Infection
|
|
Stearyldiethanolamine is a typical amine-based surfactant used in development for antibacterial freshness-keeping film or antibacterial nonwoven fabric. Stearyldiethanolamine can be used as a collector towards the surfaces of quartz and malachite, to recover efficiently malachite from quartz. Stearyldiethanolamine can disrupt bacterial cell membrane with the alkyl chain, leading to irreversible damage and cell death .
|
-
- HY-137371
-
|
|
Bacterial
Apoptosis
Antibiotic
|
Infection
Cancer
|
|
Lactonic sophorolipid is an apoptosis inducer and antimicrobial surfactant with antitumor activity. Lactonic sophorolipid regulates Bax/Bcl-gene expression through caspase-3/9 and induces apoptosis in tumor cells. Lactonic sophorolipid can disrupt cell membrane permeability and exert antibacterial effects (MIC for oral pathogens is 100-400 μg/mL). Lactonic sophorolipid promotes mitochondrial membrane potential depolarization, activates the intrinsic apoptotic pathway, and can synergize with antibiotics to enhance the antibacterial effect. Lactonic sophorolipid can be used in liver cancer research and the development of oral hygiene antibacterial agents[1][2][3].
|
-
- HY-B0798
-
|
SM-1652; Wy-44635
|
Bacterial
Antibiotic
|
Infection
|
|
Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
|
-
- HY-P1581
-
|
|
Bacterial
|
Infection
|
|
Ceratotoxin A, a 29-residue peptide isolated from the accessory gland secretion fluid, with strong anti-bacterial activity.
|
-
- HY-B0501S
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Danofloxacin-d3 (mesylate) is the deuterium labeled Danofloxacin mesylate. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone antibacterial for veterinary use.
|
-
- HY-N0849
-
-
- HY-N7123
-
-
- HY-N14346
-
|
|
Others
|
Infection
|
|
Ochracenomicin B is found in the strain of Amicolatopsis sp. MJ 950-891. Ochracenomicin B has no antibacterial effect .
|
-
- HY-B2077
-
|
Tuberactinomycin N
|
Bacterial
Antibiotic
|
Infection
|
|
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis .
|
-
- HY-N14442
-
|
|
Fungal
|
Infection
|
|
Haliangicin B has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity .
|
-
- HY-N5177
-
|
|
Bacterial
|
Infection
|
|
Cephaibol D is found in the strain of Acremonium tubaKii DSM 12774. Cephaibol D has weak antibacterial activity .
|
-
- HY-B1902
-
|
EGIS-5645
|
Antifolate
Bacterial
|
Infection
|
|
Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.
|
-
- HY-N13931
-
|
|
Bacterial
|
Infection
|
|
Azicemicin B has weak antibacterial activity. Azicemicin B without any acute toxicity in the micesup>[1].
|
-
- HY-N14439
-
|
|
Others
|
Cancer
|
|
Furaquinocin B can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .
|
-
- HY-B1366
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris .
|
-
- HY-B0177
-
-
- HY-B0576
-
-
- HY-N9087
-
|
|
Bacterial
|
Infection
|
|
Filicenol B can be isolated from the whole plant of Adiantum lunulatum. Filicenol B has antibacterial activity .
|
-
- HY-B0333S2
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamethizole-d4-1 is the deuterium labeled Sulfamethizole . Sulfamethizole is a sulfathiazole antibacterial agent .
|
-
- HY-B0454A
-
|
R18134 nitrate
|
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .
|
-
- HY-N14192
-
|
|
Antibiotic
Fungal
|
Infection
|
|
Maltophilin is a broad-spectrum antifungal antibiotic that has no antibacterial effect against Gram-positive and Gram-negative bacteria .
|
-
- HY-N14443
-
|
|
Fungal
|
Infection
|
|
Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity .
|
-
- HY-N14261
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Angiolam A is an antibiotic found in Angiococcus disciformis. Angiolam A exhibits notable antibacterial activity against Gram-positive bacteria .
|
-
- HY-105932R
-
|
Erythromycin A 9-methoxime (Standard); Wy 48314 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Lexithromycin (Standard) is the analytical standard of Lexithromycin. This product is intended for research and analytical applications. Lexithromycin is an erythromycin A derivative, with antibacterial activity.
|
-
- HY-150166
-
|
|
Bacterial
|
Infection
|
|
ClpB-IN-1 (compound 7) is a potent ClpB inhibitor. ClpB-IN-1 is a potential antibacterial agents .
|
-
- HY-N14428
-
|
|
Bacterial
|
Infection
|
|
Fosfocytocin is found in the strain of Pseudomonas fluorescens PK-52. Fosfocytocin has very weak antibacterial activity .
|
-
- HY-N14550
-
|
|
Bacterial
Fungal
|
Infection
Cancer
|
|
Cyclogregatin has anti-bacterial and fungal activity. Cyclogregatin inhibits airy ascites carcinoma with a MIC of 10 μg/mL .
|
-
- HY-U00194
-
|
Flumenique; OPC7241; DM8966
|
Bacterial
|
Infection
|
|
Vebufloxacin (Flumenique; OPC7241; DM8966) exhibits potent antibacterial activity against gram-positive and -negative bacteria.
|
-
- HY-N6248
-
|
|
Bacterial
|
Infection
|
|
Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity .
|
-
- HY-W012941
-
|
Thiophene-2-carboxaldehyde
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
2-Thiophenecarboxaldehyde (Thiophene-2-carboxaldehyde) is an antibiotic that exhibits antibacterial and nematicidal activities .
|
-
- HY-130471
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin C is an aminoglycoside antibiotic. Sannamycin C has weak antibacterial activity against Gram-positive bacteria .
|
-
- HY-N15526
-
|
|
Bacterial
|
Infection
|
|
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .
|
-
- HY-130046
-
-
- HY-107328
-
-
- HY-N14444
-
|
|
Fungal
|
Infection
|
|
Haliangicin D has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity .
|
-
- HY-135393S
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Sulfadimethoxypyrimidine-d4 is a deuterium labeled Sulfadimethoxypyrimidine. Sulfadimethoxypyrimidine is a sulfonamide antibiotic with a broad-spectrum antibacterial effect .
|
-
- HY-W839383
-
-
- HY-B0888
-
|
Sulphacetamide sodium monohydrate
|
Antibiotic
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Sulfacetamide (Sulphacetamide) sodium monohydrate is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium monohydrate has antifungal and antibacterial activities .
|
-
- HY-B0902A
-
|
MF-934 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.
|
-
- HY-133060
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin B is an aminoglycoside antibiotic. Sannamycin B has only weak antibacterial activity against a few bacteria .
|
-
- HY-W007771
-
|
|
Bacterial
BCRP
|
Infection
Cancer
|
|
Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .
|
-
- HY-N13951
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
Aranochlor A is an antibiotic found in Pseudoarachniotus roseus (HIL Y-30499). Aranochlor A exhibits antibacterial and antifungal activities .
|
-
- HY-P5735
-
|
Bac-7
|
Bacterial
|
Infection
|
|
Bactenecin 7 is an antibacterial peptide active against the growth of Enterobacter cloacae (MICs, 25 to 200μg/ml) .
|
-
- HY-N14440
-
|
|
Others
|
Cancer
|
|
Furaquinocin CA can kill HeLa S3 and B16 melanoma cells, but has no antibacterial activity .
|
-
- HY-172447
-
-
- HY-N7125
-
|
|
Bacterial
|
Others
|
|
Cinnamyl acetate has a wide application in the flavor and fragrance industry . Cinnamyl acetate is a new broad spectrum antibacterial agent .
|
-
- HY-A0133
-
-
- HY-B1119R
-
|
|
Reference Standards
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
|
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-N12400
-
|
|
Bacterial
|
Infection
|
|
10-Methyldodec-2-en-4-olide is a antibacterial agent and can be isolated from Streptomyces. 10-Methyldodec-2-en-4-olide shows antibacterial activity against B. cinerea, the yeast S. cerevisiae, bacteria S. aureus, and M. luteus .
|
-
- HY-122260
-
|
|
Bacterial
|
Infection
|
|
S-25932 is a potent 4-quinolones antibacterial agent. S-25932 shows broad gram-negative antibacterial activity. S-25932 shows inhibition for Enterobacter aerogenes, Enterobacter addlomerans, Enterobacter coloacae, Escherichia coli with MIC90 values of 1.0, 2.0, 1.0, 0.25 µg/mL, respectively .
|
-
- HY-19071
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
BK-218 is an orally active cephalosporin antibiotic that binds to penicillin-binding proteins (PBPs) and has a greater inhibitory effect than Cephalexin (HY-B0200) and Cefoxitin (HY-B1825). BK-218 has similar antibacterial activity to Cefamandole (HY-B1128) and can be used in the development of antibacterial drugs .
|
-
- HY-118906
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
BO-1165 is an antibiotic with good antibacterial activity against Gram-negative bacteria, but almost no activity against Gram-positive bacteria and anaerobic bacteria. BO-1165 has high antibacterial activity against Pseudomonas aeruginosa (MIC50=3.12 mg/L) and P. cepacia (MIC50=1.56 mg/L) .
|
-
- HY-B1894R
-
|
Ro 15-8075 free base (Standard)
|
Bacterial
Reference Standards
Antibiotic
|
Infection
|
|
Cefetamet pivoxyl (Standard) is the analytical standard of Cefetamet pivoxyl. This product is intended for research and analytical applications. Cefetamet pivoxyl is a cephalosporin antibiotic. Cefetamet pivoxyl inhibits 355 enteropathogens Keime, Gram-negative bacteria (ausgenommen Pseudomonas aeruginosa) and Legionella pneumophila .
|
-
- HY-B1894
-
|
Ro 15-8075 free base
|
Bacterial
Antibiotic
|
Infection
|
|
Cefetamet pivoxyl is a cephalosporin antibiotic. Cefetamet pivoxyl inhibits 355 enteropathogens Keime, Gram-negative bacteria (ausgenommen Pseudomonas aeruginosa) and Legionella pneumophila .
|
-
- HY-B1381A
-
|
FR-17027 trihydrate; FK-027 trihydrate; CL-284635 trihydrate
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
|
-
- HY-B1381AR
-
|
FR-17027 trihydrate (Standard); FK-027 trihydrate (Standard); CL-284635 trihydrate (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Cefixime (trihydrate) (Standard) is the analytical standard of Cefixime (trihydrate). This product is intended for research and analytical applications. Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
|
-
- HY-P5556
-
|
|
Bacterial
|
Infection
|
|
KAMP-19, a keratin-derived antimicrobial peptide, is an antimicrobial peptide against P. aeruginosa. .
|
-
- HY-B1381R
-
|
FR-17027 (Standard); FK-027 (Standard); CL-284635 (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cefixime (Standard) is the analytical standard of Cefixime. This product is intended for research and analytical applications. Cefixime (FR-17027) is an orally active antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
|
-
- HY-B1381
-
|
FR-17027; FK-027; CL-284635
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cefixime (FR-17027) is an orally active antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
|
-
- HY-E70140
-
|
EC 2.4.1; A4GNT
|
Antibiotic
|
Infection
|
|
α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and suppresses H. pylori growth .
|
-
- HY-A0111B
-
|
Ro 15-8074 hydrochloride; Deacetoxycefotaxime hydrochloride
|
Bacterial
|
Inflammation/Immunology
|
|
Cefetamet (Ro 15-8074) hydrochloride, an active cephalosporin compound, possesses abroad spectrum of activity against many aerobic gram-positiveand-negativeorganisms .
|
-
- HY-A0241R
-
|
RP54476 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Stearic acid (Standard) is the analytical standard of Stearic acid. This product is intended for research and analytical applications. Stearic acid is a long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases .
|
-
- HY-126696
-
-
- HY-N0216A
-
|
|
Bacterial
Fungal
Endogenous Metabolite
|
Others
|
|
Benzoic acid lithium is an aromatic alcohol found in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid lithium inhibits bacteria and fungi and acts as a preservative .
|
-
- HY-75828
-
|
Dibenzalacetone
|
Bacterial
|
Infection
|
|
Dibenzylideneacetone (Dibenzalacetone) is a potent inhibitor of chitinase with an IC50 value of 13.10 μM. The MIC value of Dibenzylideneacetone against Botrytis cinerea is 32 μg/mL, and the EC50 values for inhibiting mycelium growth and spore germination are 16.29 and 14.64 μg/mL, respectively. Dibenzylideneacetone can be used in research on fruit and vegetable preservatives .
|
-
- HY-B1781A
-
|
Sulfachlorpyridazine sodium
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that inhibits bacterial growth .
|
-
- HY-155071
-
|
|
Bacterial
|
Infection
|
|
MmpL3-IN-2 is an MmpL3 inhibitor with low cytotoxicity and moderate metabolic stability for tuberculosis research .
|
-
- HY-N14347
-
|
|
Bacterial
|
Infection
|
|
Ochracenomicin C is found in the strain of Amicolatopsis sp. MJ 950-891. Ochracenomicin C has a weak antibacterial effect .
|
-
- HY-B0210S
-
-
- HY-129804
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Ceforanide lysine is a second generation cephalosporin administered intravenously or intramuscularly. Ceforanide lysine has a spectrum of in vitro antibacterial activity .
|
-
- HY-N14338
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin L is an aminoglycoside antibiotic. Sannamycin L has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-N14668
-
|
|
Bacterial
|
Infection
|
|
Cladospolide B is found in the strain of Cladosporium sp. FT-0012. Cladospolide B has little antibacterial activity .
|
-
- HY-123339
-
|
Istamycin X0; IST-X0
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin G (Istamycin X0) is an aminoglycoside antibiotic and has only weak antibacterial activity against a few bacteria .
|
-
- HY-B1275
-
|
Cefalotin sodium
|
Bacterial
Antibiotic
|
Infection
|
|
Cephalothin sodium is a first generation cephem antibiotic with a wide range antibacterial activity, is active against gram-positive and gram-negative bacteria.
|
-
- HY-N14768
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
O-Demethylpaulomycin A is an antibiotic with antibacterial activity. O-Demethylpaulomycin A can inhibit Gram-positive bacteria, especially Staphylococcus aureus .
|
-
- HY-W439855
-
-
- HY-W268942
-
-
- HY-169510
-
|
|
Bacterial
Fungal
Parasite
|
Infection
|
|
Aurachin C is an isoprenoid quinoline alkaloid with antiplasmodial, antifungal and antibacterial effects. Aurachin C is a selective terminal oxidases inhibitor .
|
-
- HY-N14145
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Collinone is a recombinant angular polyketide antibiotic. Collinone shows antibacterial activities for gram-positive bacterial. Collinone shows cytotoxicity .
|
-
- HY-111154
-
|
|
Bacterial
|
Infection
|
|
BPH-608 is a bacterial undecenyl diphosphate synthase (UPPS) inhibitor (IC50=590 nM) with antibacterial activity .
|
-
- HY-N3373
-
|
|
Bacterial
|
Infection
|
|
Loganetin is a non-toxic natural product that may be applied in the antibacterial agent development for treating multidrug-resistant Gram negative infections.
|
-
- HY-N15080
-
-
- HY-N2604
-
-
- HY-114824
-
|
|
Bacterial
|
Others
|
|
Streptovitacin A is a compound with antibacterial and antiproliferative activities isolated from microorganisms, which has inhibitory effects on a variety of bacteria and tumor cells.
|
-
- HY-N5002
-
|
|
Bacterial
|
Infection
|
|
(+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus . Antibacterial activity .
|
-
- HY-N10181
-
|
Simplifusidic acid I
|
Bacterial
|
Infection
|
|
11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.
|
-
- HY-122071
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Bicyclomycin is an antibiotic. Bicyclomycin has anti-Bacterial activity against Gram-negative bacteria except Proteus and Pseudomonas aeruginosa .
|
-
- HY-125745
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Loloatin B 10 is an antibiotic, which exhibits antibacterial efficacy against gram positive antibiotic resistant human pathogens .
|
-
- HY-138210
-
|
|
Fungal
|
Infection
|
|
N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells .
|
-
- HY-B0200
-
|
Cefalexin; Cephacillin
|
Penicillin-binding protein (PBP)
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-N3342
-
|
|
Bacterial
|
Infection
|
|
Macrocarpal E is a potent antibacterial agent. Macrocarpal E is a phloroglucinol dialdehyde diterpene derivatives that can be found in the leaves of Eucalyptus macrocarpa .
|
-
- HY-N13920
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Avilamycin C is an avilamycin-type antibiotic. Avilamycin C has antibacterial activity and can inhibit Gram-positive bacteria .
|
-
- HY-P5626
-
|
|
Bacterial
|
Infection
|
|
Seabream hepcidin is an antimicrobial peptide with anti-bacterial (V.anguillarum), fungal (S.cerevisiae) and viral hemorrhagic septicemia virus activity .
|
-
- HY-N11421
-
|
23-DMT; 23-Demycinosyltylosin
|
Bacterial
|
Infection
|
|
23-O-Demycinosyltylosin (23-DMT) is a 23-O-demycinosyltylosin (DMT) acyl derivative with antibacterial activity .
|
-
- HY-N14945
-
|
|
Telomerase
|
Cancer
|
|
Diazaphilonic acid is found in the strain of Talaramuces flavus PF1195. Diazaphilonic acid has no antibacterial activity, but inhibits the ability of DNA amplification and telomerase .
|
-
- HY-B1174A
-
|
Kanamycin B sulfate
|
Bacterial
Antibiotic
|
Infection
|
|
Bekanamycin (Kanamycin B) sulfate is a minor component of the kanamycin complex, an aminoglycoside antibiotic isolated from Streptomyces kanamyceticus, with antibacterial activity .
|
-
- HY-N13905
-
-
- HY-142124
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Kalimantacin A is a potent antibiotic. Kalimantacin A shows antibacterial activity against staphylococcus including methicillin-resistant staphylococcus aureus (MRSA) .
|
-
- HY-145455
-
|
|
Bacterial
|
Infection
|
|
Salazopyridazine is an antibacterial agent. Salazopyridazine shows activities against ulcerative colitis. Salazopyridazine can be used for the research of rheumatic diseases .
|
-
- HY-124334
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
L-161240 is an antibiotic, which exhibits antibacterial activity against Escherichia coli, through inhibition of LpxC enzyme (Ki is 50 nM) .
|
-
- HY-B1530
-
|
(±)-Ammonium lactate
|
Bacterial
|
Infection
|
|
Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis .
|
-
- HY-B0356S
-
|
Bay-09867-d8 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
Ciprofloxacin-d8 (hydrochloride) is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
|
-
- HY-118234
-
|
|
Bacterial
|
Others
|
|
(Rac)-PD 138312 is the racemate of PD 138312. PD 138312 is a potent and orally active antibacterial agent against Gram-positive bacteria .
|
-
- HY-P4648
-
|
|
Bacterial
|
Infection
|
|
H-Trp-Trp-Trp-OH is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity .
|
-
- HY-N3343
-
|
(-)-Macrocarpal D
|
Bacterial
|
Infection
|
|
Macrocarpal D is a potent antibacterial agent. Macrocarpal D is a phloroglucinol dialdehyde diterpene derivatives that can be found in the leaves of Eucalyptus macrocarpa .
|
-
- HY-B0356S1
-
|
Bay-09867-d8
|
Bacterial
Antibiotic
|
Infection
|
|
Ciprofloxacin-d8 is the deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
|
-
- HY-N14165
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
Endusamycin can inhibit the protein and nucleic acid synthesis of Ehrlician ascites cancer cells, and has no anti-bacterial and anti-yeast effect .
|
-
- HY-N5197
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Dapdiamide A is an antibiotic found in Pantoea agglomerans CU0119 strain, exhibiting antibacterial activity and potential applications in anti-infective research .
|
-
- HY-14957
-
|
T-3912
|
Bacterial
Antibiotic
|
Infection
|
|
Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.
|
-
- HY-N13915
-
|
|
Bacterial
Fungal
|
Infection
|
|
Scorodonin has anti-bacterial, Streptomyces and fungal effects. Scorodonin inhibits DNA-dependent RNA polymerases with an IC50 of 25 μg/mL .
|
-
- HY-N0704
-
|
|
Sirtuin
PPAR
Fatty Acid Synthase (FASN)
c-Myc
Bacterial
|
Infection
Metabolic Disease
Cancer
|
|
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .
|
-
- HY-117254
-
|
|
Bacterial
|
Infection
|
|
BAS00127538 is a Lipid II inhibitor with antibacterial activity. As the first small molecule Lipid II inhibitor, BAS00127538 has a structure that is significantly different from compounds that naturally bind to Lipid II, such as vancomycin. The activity of BAS00127538 in terms of cytotoxicity and Lipid II binding is of great significance in antibacterial effects. Studies on BAS00127538 have shown that it has the potential to inhibit infection .
|
-
- HY-118118
-
|
|
Fungal
|
Infection
|
|
Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite with strong antifungal activity. Phlebiakauranol aldehyde exhibits significant antibacterial and cytotoxic activities against a variety of plant pathogens. The aldehyde group and high number of hydroxyl groups of Phlebiakauranol aldehyde are considered to be the main reasons for its biological activity. The two acetic acid derivatives of Phlebiakauranol aldehyde only exhibit very weak antifungal and antibacterial activities and moderate cytotoxic activity .
|
-
- HY-69174
-
|
|
Bacterial
|
|
|
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial compound with antibacterial activity against a variety of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The application potential of 1-Amino-2,5-anhydro-1-deoxy-D-mannitol lies in its ability to effectively combat common drug-resistant bacterial infections. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol may become an emerging antibacterial agent in clinical inhibition.
|
-
- HY-113795
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Aldgamycin E is a neutral macrolide antibiotic that can be derived from culture filtrates of Streptomyces lavendulae. Aldgamycin E has antibacterial activity .
|
-
- HY-122362
-
|
BRL-3475 sodium; Carbenicillin phenyl sodium
|
Bacterial
|
Infection
|
|
Carfecillin (BRL-3475) sodium is an orally active phenyl ester of carbenicillin with antibacterial activity. Carfecillin can be used for the study of urinary tract infections .
|
-
- HY-N9112
-
|
|
Bacterial
|
Infection
|
|
Eriodictyol 7, 3'-dimethyl ether (compound 11) is the first flavonoid extract from B. riparia with antioxidant and antibacterial activity .
|
-
- HY-N8401
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Musellactone is a lactone that can be isolated from Musella lasiocarpa. Musellactone is an antibiotic, that exhibits antibacterial activity against Bacillus megaterium and Sarcina lutea .
|
-
- HY-148209
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes .
|
-
- HY-N8281
-
|
|
Bacterial
|
Infection
|
|
Daldinone A (Compound 4) is an antibacterial agent that can be isolated from Nigrospora oryzae. Daldinone A has antimicrobial potential against P. aeruginosa .
|
-
- HY-N0644
-
|
|
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Carnosic acid is an orally active lipid absorption inhibitor. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.
|
-
- HY-W019032
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
|
-
- HY-B1784
-
|
Sulfaisodimidine
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidin can be used for the research of lower urinary tract infections .
|
-
- HY-W039756
-
|
NSC 334362
|
Amino Acid Derivatives
|
Others
|
|
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent .
|
-
- HY-N7089
-
|
quinazolinedione
|
Bacterial
|
Infection
|
|
Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors .
|
-
- HY-Z9100
-
|
|
Antibiotic
|
Infection
|
|
N-demethyl Promethazine hydrochloride is a metabolite of Phenothiazine (HY-Y0055). Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities.
|
-
- HY-N14396
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin F is an aminoglycoside antibiotic. Sannamycin F has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-N7097
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic with antibacterial activity against a number of mucoid and non-mucoid strains of Pseudomonas aeruginosa .
|
-
- HY-A0110A
-
|
CTM-HE hydrochloride; SCE-2174 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
|
Cefotiam hexetil hydrochloride (CTM-HE) is an oral third-generation cephalosporin, which is a proagent of cefotiam, but has no anti-bacterial property. Cefotiam is an antibiotic .
|
-
- HY-N14380
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sannamycin K is an aminoglycoside antibiotic. Sannamycin K has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-B1731
-
|
|
Bacterial
|
Neurological Disease
|
|
Phenyl salicylate (PS) has antibacterial activity when hydrolyzed in small intestine and is often used as nervous system inhibitor and intestinal preservative .
|
-
- HY-N1843
-
|
|
Bacterial
|
Infection
|
|
3-Isomangostin hydrate (Compound 17) is an xanthone that can be isolated from Cratoxylum formosum ssp. pruniflorum and exhibits antibacterial activity .
|
-
- HY-B1252B
-
-
- HY-N15038
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Haloquinone is a quinone antibiotic. Haloquinone has strong anti-bacterial activity on Halobacteria, and also has effects on Gram-positive bacteria and mycoplasma .
|
-
- HY-16753
-
|
SMT19969
|
Bacterial
|
Infection
|
|
Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25 µg/mL (MIC90=8 µg/mL) against C. difficile.
|
-
- HY-N15418
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Mikanolide is a sesquiterpene that has antibacterial properties. Mikanolide inhibits the growth of Staphylococcus aureus with a zone of 14 mm at a concentration of 100 μg per disk .
|
-
- HY-B0147S1
-
-
- HY-N11982
-
|
|
Bacterial
|
Infection
Cancer
|
|
Emeguisin A is a depsidone with an antibacterial activity. Emeguisin A inhibits the human colon carcinoma (HCT-116) cell viability with rate of 87.06% .
|
-
- HY-B0200A
-
|
Cefalexin hydrochloride; Cephacillin hydrochloride
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-123319A
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antofloxacin is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species .
|
-
- HY-123319
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin hydrochloride shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Antofloxacin hydrochloride is a weak, reversible inhibitor of CYP1A2 for the research of infections caused by a diverse group of bacterial species .
|
-
- HY-B0200C
-
|
Cefalexin hydrochloride monohydrate; Cephacillin hydrochloride monohydrate
|
Penicillin-binding protein (PBP)
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cephalexin (Cefalexin) hydrochloride monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-B0200D
-
|
Cefalexin (lysine); Cephacillin (lysine)
|
Penicillin-binding protein (PBP)
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Cephalexin (Cefalexin) lysine is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin lysine has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin lysine targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin lysine is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-B0200B
-
|
Cefalexin hydrate; Cephacillin hydrate
|
Penicillin-binding protein (PBP)
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-N14974
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Ericamycin is an antibiotic that exhibits antibacterial activity against Gram-positive activity, inhibits Staphylococcus aureus with MIC of 0.004-0.016 µg/mL .
|
-
- HY-19814
-
-
- HY-W134301
-
|
Potassium alum
|
Biochemical Assay Reagents
|
Others
|
|
Aluminum potassium sulfate (Potassium alum) is a biochemical agent that has water purification and antibacterial activity. Aluminum potassium sulfate can be used in the research of microbiology and environmental science .
|
-
- HY-P5664
-
|
|
Bacterial
|
Infection
|
|
Maximin S4 is an antimicrobial peptide derived from toad Bombina maxima. Maximin S4 has antibacterial activity against mycoplasma .
|
-
- HY-118021
-
|
YL-0358M-A
|
Antibiotic
|
Infection
|
|
Hatomamicin is an alkaloid antibiotic that can be isolated from the culture filtrate of Sucrose Polyspora. Hatomamicin exhibits antibacterial activity against Gram-positive bacteria .
|
-
- HY-16487
-
|
TMFX; TA-167 free acid; A-62254 free acid
|
Bacterial
Antibiotic
|
Infection
|
|
Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections .
|
-
- HY-169384
-
|
|
Bacterial
|
Infection
|
|
Antimycobacterial agent-10 (compound 5) is a DNA gyrase inhibitor with anti-bacterial actiity (IC50=96 nM, M. tuberculosis gyrase).
|
-
- HY-N14485
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Nebramycin IV is an aminoglycoside antibiotic. Nebramycin IV has a broad antibacterial spectrum and has a strong effect on Gram-positive and negative bacteria and mycobacteria .
|
-
- HY-N13906
-
-
- HY-N14579
-
|
|
Bacterial
Fungal
|
Infection
|
|
Racemomycin D has broad spectrum antibacterial activity and antifungal effect, and it can inhibit PR-8 of influenza virus in tissue culture .
|
-
- HY-N2192
-
-
- HY-114551
-
|
Racemomycin C; Antibiotic S15-1B
|
Bacterial
Fungal
|
Infection
|
|
Racemomycin C has broad spectrum antibacterial activity and antifungal effect, and it can inhibit PR-8 of influenza virus in tissue culture .
|
-
- HY-B0210R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cefoperazone (Standard) is the analytical standard of Cefoperazone. This product is intended for research and analytical applications. Cefoperazone, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-136150
-
|
|
Bacterial
|
Infection
|
|
Methyl camosate is a diterpene isolated from Salvia officinalis or Rosmarinus officinalis. Methyl camosate has potent antioxidant and anti-bacterial activity .
|
-
- HY-108279
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity .
|
-
- HY-139618
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
DuP-721 is a broad spectrum and orally active antibacterial agent against a variety of clinically susceptible and resistant bacteria, especially M. tuberculosis .
|
-
- HY-113595
-
|
TMFX hydrochloride; TA-167; A-62254
|
Antibiotic
Bacterial
|
Infection
|
|
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections .
|
-
- HY-135389
-
|
|
Drug Metabolite
Antibiotic
|
Infection
|
|
Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .
|
-
- HY-124923
-
|
|
Bacterial
|
Infection
Cancer
|
|
Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties .
|
-
- HY-N10391
-
|
Cleistenolide
|
Bacterial
|
Infection
Cancer
|
|
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity .
|
-
- HY-112586S1
-
|
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Sulfaethoxypyridazine- 13C6 is the 13C6 labeled Sulfaethoxypyridazine. Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs.
|
-
- HY-N14753
-
|
|
Bacterial
|
Infection
Cancer
|
|
Juglomycin A has a broad spectrum of antibacterial and mycobacterial effects, and has the effect of inhibiting ehrlician ascites cancer in mice and prolongating life with 1 mg/kg .
|
-
- HY-B0454S
-
-
- HY-133937
-
|
|
Bacterial
HIV
|
Infection
|
|
Sulfametrole is an orally active and potent antibacterial. Sulfametrole can be used for infections research, such as HIV, severe pneumonia and UTIs (urinary tract infections) .
|
-
- HY-B1043
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Piromidic acid is an antibacterial agent. Piromidic acid is active against gramnegative bacteria and staphylococci and can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-126185
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Nibroxane is an orally active antibacterial agent. Nibroxane can be metabolized to 2-methyl-5-nitro-m-dioxane in mice .
|
-
- HY-144701
-
-
- HY-B0699
-
|
HR 810
|
Antibiotic
Bacterial
|
Infection
|
|
Cefpirome (HR 810) is a fourth generation cephalosporin. Cefpirome shows antibacterial activity. Cefpirome also has in vitro activity against Streptococcus pneumoniae .
|
-
- HY-146816
-
|
|
Topoisomerase
|
Infection
|
|
NBTIs-IN-6 is a bacterial topoisomerase inhibitor with certain antibacterial activity. Among them, the MIC90 for fluoroquinolone-resistant MRSA was 2 μg/mL .
|
-
- HY-167644
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cefoxazole is a β-lactam antibiotic containing an isoxazole moiety and exhibits antibacterial activity. Cefoxazole can be used in studies related to infectious diseases .
|
-
- HY-W015879S
-
|
|
Bacterial
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
2-Heptanol-d5 is deuterated labeled 2-Heptanol (HY-W015879). 2-Heptanol is one of the chemical compounds identified in turmeric and turmeric rhizome essential oil. 2-Heptanol can speed up amino acid metabolism and slow down membrane transport, exhibiting antibacterial activity. The rhizome essential oil has good antibacterial and antioxidant properties .
|
-
- HY-W014338
-
|
|
Bacterial
|
|
|
Phenyl(9H-purin-6-yl)amine is an antibacterial compound with the activity of inhibiting bacterial growth. The application of phenyl(9H-purin-6-yl)amine can be used to develop new antibacterial compounds. Phenyl(9H-purin-6-yl)amine has shown potential inhibitory effects in medical research.
|
-
- HY-117260
-
-
- HY-P1607
-
-
- HY-N8443
-
|
|
Bacterial
|
Infection
|
|
Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .
|
-
- HY-N13998
-
|
|
Bacterial
|
Infection
|
|
Cephalonic acid is a pentaprenyl terpenoid compound that can be isolated from the fermentation broth of Cephaloscorlum caerulens. Cephalonic acid has weak antibacterial activity against Staphylococcus aureus .
|
-
- HY-116872
-
|
|
Bacterial
|
Infection
|
|
MAC13772 is a potent inhibitor of the enzyme BioA (IC50=250 nM), the antepenultimate step in biotin biosynthesis. MAC13772 is a novel antibacterial compound .
|
-
- HY-W403633
-
|
|
Bacterial
|
Infection
|
|
Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity .
|
-
- HY-A0130R
-
|
Sulfametopyrazine (Standard); AS-18908 (Standard)
|
Reference Standards
Parasite
Bacterial
Antibiotic
|
Infection
|
|
Sulfalene (Standard) is the analytical standard of Sulfalene. This product is intended for research and analytical applications. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial.
|
-
- HY-123614
-
|
|
Bacterial
|
Infection
|
|
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent with good in vitro bacteriostatic activity, especially having a significant inhibitory effect on Gram-positive bacteria .
|
-
- HY-21210
-
|
|
Bacterial
|
Infection
|
|
6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-, derived from 2,3-Bis(bromomethyl)quinoxaline, shows antibacterial activity .
|
-
- HY-N15184
-
|
Pradimicin C
|
Bacterial
Fungal
|
Infection
|
|
Benanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis .
|
-
- HY-N13267
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
(-)-cis-Myrtanol is a terpenoid compound derived from Artemisia dracunculus that exhibits effective antibacterial activity against harmful gut bacteria such as Bifidobacterium bifidum .
|
-
- HY-W011517
-
|
2FA
|
Bacterial
|
Infection
Others
|
|
2-Fluoroadenosine (2FA) is a nucleoside analogue. 2-Fluoroadenosine has antibacterial activity with IC50 value of 0.842 mM for Vibrio microvibrio .
|
-
- HY-N14754
-
|
|
Bacterial
|
Infection
Cancer
|
|
Juglomycin B has a broad spectrum of antibacterial and mycobacterial effects, and has the effect of inhibiting ehrlician ascites cancer in mice and prolongating life with 1 mg/kg .
|
-
- HY-W579772
-
|
|
Bacterial
|
Infection
|
|
Tetrabutylammonium (nitrite) is a compound with antibacterial activity. Tetrabutylammonium (nitrite) has inhibitory activity against some Gram-negative bacteria and some Gram-positive bacteria .
|
-
- HY-151102
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Fabimycin is a FabI inhibitor with potent antibacterial activity against gram-negative bacteria. Fabimycin is effective against drug-resistant gram-negative Infections in vivo .
|
-
- HY-N7321A
-
|
|
Bacterial
|
Infection
Cancer
|
|
(R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells .
|
-
- HY-N14871
-
|
|
Bacterial
|
Infection
|
|
Pyrronamycin A has antibacterial activity against Gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella .
|
-
- HY-P10361
-
-
- HY-116271
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .
|
-
- HY-169818
-
-
- HY-B0308S
-
-
- HY-121620S
-
|
1-Monolaurin-d23
|
Bacterial
SARS-CoV
|
Infection
|
|
Monolaurin-d23 is the deuterium labeled Monolaurin . Monolaurin (1-Monolaurin) possesses anti-viral and anti-bacterial activity .
|
-
- HY-16158
-
|
Wy-4508; Aminocyclohexylpenicillin; Ciclacillin
|
Bacterial
Antibiotic
|
Infection
|
|
Cyclacillin (Wy-4508) is an orally active aminopenicillin antibiotic, shows antibacterial activity against a wide range of gram-positive and gram-negative pathogens .
|
-
- HY-N5125
-
-
- HY-B0454S1
-
-
- HY-W013549
-
|
6-APA
|
Drug Metabolite
Bacterial
|
Infection
Inflammation/Immunology
|
|
6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses .
|
-
- HY-N9971
-
-
- HY-N0129R
-
|
|
Reference Standards
Bacterial
|
Infection
|
|
Sclareolide (Standard) is the analytical standard of Sclareolide. This product is intended for research and analytical applications. Sclareolide is isolated from the flower of Perilla frutescens with antibacterial and cytotoxic activities[1].
|
-
- HY-N14948
-
|
|
Bacterial
|
Infection
|
|
2"-N-Formimidoylsporaricin A has the activity of anti-Gram-positive bacteria and negative bacteria, and also has the antibacterial activity against the aminoglycol-resistant bacteria .
|
-
- HY-N6895
-
|
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
|
Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM .
|
-
- HY-W392258A
-
|
|
Biochemical Assay Reagents
|
Infection
|
|
Poly(methyl vinyl ether-alt-maleic anhydride) (MW 1080000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
|
-
- HY-P4746
-
|
|
Bacterial
|
Infection
|
|
LL-37 FKR is the C-terminal fragment of LL-37. LL-37 FKR plays an important role in antibacterial performance .
|
-
- HY-165291
-
|
|
Bacterial
|
Metabolic Disease
|
|
Olaflur hydrofluoride is an amine fluoride with anticaries activity. Olaflur hydrofluoride can be used as an ingredient of toothpastes . Olaflur hydrofluoride also exhibits antibacterial activity .
|
-
- HY-B0330S
-
|
(-)-Ofloxacin-d8
|
Bacterial
Antibiotic
|
Infection
|
|
Levofloxacin-d8 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
|
-
- HY-N4116
-
|
|
Fungal
|
Infection
Cancer
|
|
Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants .
|
-
- HY-136443
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
4-Epitetracycline hydrochloride is a reversible epimer of Tetracycline (HY-A0107) that can be interconverted in nature. 4-Epitetracycline hydrochloride exhibits antibacterial activity .
|
-
- HY-B2234
-
|
iodopovidone
|
Bacterial
|
Infection
|
|
Povidone iodine (iodopovidone) displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively.
|
-
- HY-N9343
-
-
- HY-113557
-
-
- HY-109754
-
|
PF-03709270
|
Bacterial
Antibiotic
|
Infection
|
|
Sulopenem etzadroxil (PF-03709270) is an orally available ester proagent form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria.
|
-
- HY-N0056
-
-
- HY-N14491
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Coumamidine γ2 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .
|
-
- HY-18715
-
|
(S)-Ornidazole; Levornidazole
|
Bacterial
Parasite
|
Infection
|
|
Ornidazole Levo- is the levo-isomer of Ornidazole. Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole Levo- is the less active isomer.
|
-
- HY-W856812
-
|
|
Drug Intermediate
|
Others
|
|
Penicillanic acid (sodium) is a key drug intermediate. Penicillanic acid (sodium) can be used to synthesize β-lactamase inhibitors and prodrugs. Penicillanic acid (sodium) derivative Mecillinam has antibacterial activity .
|
-
- HY-159118
-
|
|
Bacterial
|
Infection
|
|
PC-Qz1 is a mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor with an IC50 of 470 nM. PC-Qz1 has antibacterial activity .
|
-
- HY-N8186
-
|
|
Bacterial
|
Infection
|
|
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-161264
-
|
|
Bacterial
|
Infection
|
|
Antiviral agent 49 (compound 4q) is dual antiviral and antibacterial agent. Antiviral agent 49 shows anti-enterococcus activity and anti-staphylococcal activity .
|
-
- HY-W006449
-
|
|
Bacterial
Antibiotic
|
Others
|
|
PNU-105368 is a compound with antibacterial activity and a metabolite of linezolid. It exists mainly in the form of the original form and two metabolites in the human body and is excreted through the kidneys and feces.
|
-
- HY-B0454S2
-
|
R18134-d2
|
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Miconazole-d2 is the deuterium labeled Miconazole . Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects .
|
-
- HY-30219
-
|
D-3-Phenyllactic acid
|
Bacterial
Endogenous Metabolite
Bcl-2 Family
|
Infection
|
|
D-(+)-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans .
|
-
- HY-W035409
-
RPW-24
1 Publications Verification
|
Bacterial
|
Infection
|
|
RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity .
|
-
- HY-P1350
-
|
|
Bacterial
|
Infection
|
|
H-Lys-Trp-Lys-OH is a small molecule peptide which displays antibacterial and antiviral activities extracted from patent CN 104072579 A, Compound AMP12.
|
-
- HY-W392258
-
|
|
Biochemical Assay Reagents
|
Infection
|
|
Poly(methyl vinyl ether-alt-maleic anhydride) (MW 216000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
|
-
- HY-132923
-
|
|
Bacterial
|
Infection
|
|
NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance.
|
-
- HY-A0130S
-
-
- HY-105180
-
|
BO-2727 free acid
|
Bacterial
|
Infection
|
|
Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa .
|
-
- HY-N0337S
-
-
- HY-N15008
-
|
|
Bacterial
|
Infection
|
|
3-epi-Deoxynegamycin shows antibacterial activity against most Gram-positive bacteria, and its anti-Gram-negative bacteria activity is a little weak .
|
-
- HY-168900
-
|
|
Bacterial
|
Infection
|
|
Antibiofilm agent-15 (Compound 17) is an antibacterial agent. Antibiofilm agent-15 inhibits biofilm formation in Gram-positive and Gram-negative bacteria .
|
-
- HY-N14490
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Coumamidine γ1 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .
|
-
- HY-16764A
-
|
JNJ-Q2 hydrochloride
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Acorafloxacin hydrochloride (JNJ-Q2 hydrochloride) is a broad-spectrum fluoroquinolone anti-bacterial drug being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia .
Acorafloxacin hydrochloride (Avarofloxacin ) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value .
Acorafloxacin hydrochloride (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections .
|
-
- HY-W653936
-
|
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Cancer
|
|
Cephalexin-d5 (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-B0200R
-
|
Cefalexin (Standard); Cephacillin (Standard)
|
Penicillin-binding protein (PBP)
Reference Standards
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Cephalexin (Standard) is the analytical standard of Cephalexin. This product is intended for research and analytical applications. Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
|
-
- HY-121178
-
|
|
Bacterial
Fungal
|
Infection
|
|
Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.
|
-
- HY-114816S
-
|
|
Isotope-Labeled Compounds
ADC Linker
Bacterial
|
Infection
Inflammation/Immunology
|
|
N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
|
-
- HY-N1096S1
-
|
|
Isotope-Labeled Compounds
Bacterial
Parasite
|
Infection
|
|
Veratraldehyde-d3 is the deuterium labeled Veratraldehyde (HY-N1096). Veratraldehyde is an orally active aromatic compound and antibacterial agent. Veratraldehyde can be isolated from essential oils of plants such as peppermint and ginger. Veratraldehyde targets the PilY1 protein. Veratraldehyde has antibacterial activity against Pseudomonas aeruginosa. Veratraldehyde has a repellent effect against mosquitoes and ticks. Veratraldehyde can be used as a flavoring agent .
|
-
- HY-171317
-
|
|
Bacterial
|
Infection
|
|
SMARt751 targets the transcriptional regulatory factor VirS, inhibits its DNA binding ability, upregulates the mymA operon expression, thereby activating Ethionamide (HY-B0276), enhancing the antimicrobial activity of Ethionamide. SMARt751 enhances the antibacterial activity of Ethionamide against M. tuberculosis, reverses the Ethionamide resistance. SMARt751 improves the antibacterial effect of Ethionamide and reduces its effective dose in mouse models. SMARt751 can cross blood brain barrier .
|
-
- HY-155462
-
|
|
Bacterial
|
Infection
|
|
hERG-IN-1 (compound 2a) is an antibacterial agent and inhibitor of hERG. hERG-IN-1 inhibits pulmonary infection caused by Pseudomonas aeruginosa strain ATCC 27853 .
|
-
- HY-P4747
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in antibiotics .
|
-
- HY-N14088
-
|
|
Bacterial
|
Infection
|
|
Chrysospermin A has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-138145
-
|
|
Fungal
Bacterial
|
Infection
|
|
8-Acetyl-7-hydroxycoumarin is a coumarin-like compound found in Mexican patchouli (Tagetes lucida) that has anti-bacterial and anti-fungal activities .
|
-
- HY-B1444
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
|
-
- HY-B1921
-
|
Midecamycin acetate; Ponsinomycin
|
Bacterial
|
Infection
|
|
Miocamycin (Midecamycin acetate) is a derivative of midecamycin (HY-B1908), a macrolide antibiotic that can be isolated from a culture broth of Streptomyces mycarofaciens. Miocamycin has antibacterial properties .
|
-
- HY-17592
-
|
|
Parasite
Bacterial
|
Infection
Cancer
|
|
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble adenylyl cyclase through binding to the allosteric activator site (IC50: 4 μM) .
|
-
- HY-B0330S1
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
(S)-Ofloxacin-d3 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
|
-
- HY-128467R
-
|
Sodium dehydroacetate (Standard)
|
Reference Standards
Bacterial
Fungal
|
Infection
|
|
Dehydroacetic acid (sodium) (Standard) is the analytical standard of Dehydroacetic acid (sodium). This product is intended for research and analytical applications. Dehydroacetic acid sodium, a pyrone derivative acts as an antibacterial and antifungal agent. Dehydroacetic acid possess phytotoxic activity .
|
-
- HY-W718418
-
|
|
Others
|
Others
|
|
3-Ketoadipic acid is a dicarboxylic acid containing a keto group that can be isolated from Brazilian propolis (Et-Bra). Brazilian propolis exhibits antibacterial, antifungal, and antiparasitic activities .
|
-
- HY-170312
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial-IN-1 (compound 17) exhibits strong antibacterial activity against S. aureus and E. coli, with the inhibition zone diameter of 18 , 16 mm/mg, respectively .
|
-
- HY-N3960
-
|
|
PPAR
Bacterial
|
Infection
Metabolic Disease
|
|
Glycyrin is a PPAR-γ ligand of licorice. Glycyrin can decrease the blood glucose levels of genetically diabetic mice. Glycyrin also shows antibacterial activity .
|
-
- HY-17492
-
-
- HY-N0644R
-
|
|
Apoptosis
Bacterial
Reference Standards
|
Inflammation/Immunology
Cancer
|
|
Carnosic acid (Standard) is the analytical standard of Carnosic acid. This product is intended for research and analytical applications. Carnosic acid has demonstrated inhibition of oxidative stress and inflammation, suppression of cell proliferation, and antibacterial activity.
|
-
- HY-B0308R
-
|
CI-978 (Standard); AT-4140 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sparfloxacin (Standard) is the analytical standard of Sparfloxacin. This product is intended for research and analytical applications. Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .
|
-
- HY-130840
-
|
|
Bacterial
|
Cancer
|
|
LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity .
|
-
- HY-N12600
-
|
|
Bacterial
|
Infection
|
|
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .
|
-
- HY-B0289
-
-
- HY-B1418
-
|
CL-298741; YTR-830H
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .
|
-
- HY-N10133
-
|
3′-Prenylnaringenin
|
Bacterial
|
Others
|
|
Licoflavanone (compopund 2) is a flavanone. Licoflavanone can be isolated from the MeOH extract of Air-dried leaves of G. glabra var. typica. Licoflavanone has antibacterial activity .
|
-
- HY-N1944A
-
|
|
Bacterial
|
Infection
|
|
cis-Nerolidol is a sesquiterpene alcohol that can be found in various plants. cis-Nerolidol exhibits antioxidant and antibacterial activities. cis-Nerolidol can also potentiate the action of antibiotics .
|
-
- HY-N12180A
-
-
- HY-13234S
-
-
- HY-N3920
-
|
|
Bacterial
|
Infection
|
|
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .
|
-
- HY-B0177S
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Tinidazole-d5 is the deuterium labeled Tinidazole. Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa .
|
-
- HY-N7066
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Difloxacin hydrochloride is a broad-spectrum antibacterial agent. Difloxacin hydrochloride inhibits bacterial DNA gyrase and exhibits a concentration-dependant bactericidal effect by interference with the activity of DNA gyrase and topoisomerase IV .
|
-
- HY-B0210AR
-
|
CP 52640-2 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cefoperazone (sodium salt) (Standard) is the analytical standard of Cefoperazone (sodium salt). This product is intended for research and analytical applications. Cefoperazone sodium salt (CP 52640-2), a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity .
|
-
- HY-B0454R
-
|
R18134 (Standard)
|
Reference Standards
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Miconazole (Standard) is the analytical standard of Miconazole. This product is intended for research and analytical applications. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects .
|
-
- HY-W099682
-
|
n-Hexyl trimethylammonium bromide
|
Biochemical Assay Reagents
|
Others
|
|
Hexyltrimethylammonium bromide is a cationic surfactant, quaternary ammonium compound, detergent, emulsifier, phase transfer catalyst, antibacterial agent, electrochemical device, corrosion inhibitor, micelle former, industrial chemical.
|
-
- HY-122382
-
|
NF-602
|
Parasite
Bacterial
|
Infection
|
|
Levofuraltadone (NF-602) is an antibacterial and antiparasitic agent. Levofuraltadone has anti-trypanosomiasis activity and can be used in the study of human african trypanosomiasis as well as bacterial infections .
|
-
- HY-163734
-
|
|
Bacterial
Tyrosinase
|
Infection
|
|
Tyrosinase-IN-30 (compound 11c) is a potent tyrosinase inhibitor with an IC50 value of 4.52 µM. Tyrosinase-IN-30 shows anti-bacterial activity .
|
-
- HY-13573R
-
|
CLI 86815 (Standard); L 627 (Standard); LJC 10627 (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Biapenem (Standard) is the analytical standard of Biapenem. This product is intended for research and analytical applications. Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum.
|
-
- HY-144253
-
|
|
Akt
ERK
|
Cancer
|
|
AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC50 value of 1.15μM.
|
-
- HY-W777997
-
|
|
Bacterial
|
Infection
|
|
Nocardicin B is originally isolated from Nocardia uniformis subsp. tsugamanensis ATCC 21806. Nocardicin B only has a weak antibacterial effect on Proteus and axillary bacillus .
|
-
- HY-N0708
-
-
- HY-N2639
-
|
|
Bacterial
|
Infection
|
|
Macatrichocarpin A is a flavanone with anti-bacterial activity. Macatrichocarpin A inhibits Bacillus subtilis with MIC value of 26.5 μM. Macatrichocarpin A can be isolated from the leaves of Macaranga trichocarpa .
|
-
- HY-106339R
-
|
Mucomycin (Standard)
|
Reference Standards
Bacterial
|
Infection
Inflammation/Immunology
|
|
Lymecycline (Standard) is the analytical standard of Lymecycline. This product is intended for research and analytical applications. Lymecycline is a tetracycline derivative, with broad-spectrum antibacterial activity and also has anti-inflammatory property.
|
-
- HY-122414
-
|
|
Antibiotic
Bacterial
Fungal
|
Infection
|
|
Phosalacine is a phosphorouscontaining tripeptide herbicidal antibiotic that can be isolated from soil isolate Kitasatosporia phosalacinea KA-338. Phosalacine also shows antibacterial and antifungal activity .
|
-
- HY-127160
-
|
|
Parasite
Bacterial
|
Infection
|
|
Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
|
-
- HY-N2876
-
|
|
Parasite
Bacterial
|
Infection
|
|
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC50: 4.39 μM), and antimycobacterium activity (IC50: 4.50 μM) against M. tuberculosis H37Ra .
|
-
- HY-N1952
-
|
Iso-Eugenol
|
Bacterial
|
Infection
|
|
Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively .
|
-
- HY-P5715
-
|
|
Bacterial
|
Infection
|
|
Im6 is an antimicrobial peptide. Im6 is active against S. aureus and B.subtilis (Gram-positive bacterial) .
|
-
- HY-N1952R
-
|
Iso-Eugenol (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
Isoeugenol (Standard) is the analytical standard of Isoeugenol. This product is intended for research and analytical applications. Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively .
|
-
- HY-146426
-
|
|
Bacterial
|
Infection
|
|
MraY-IN-2 (compound 6) is a potent MurNAc-pentapeptide translocase (MraY) inhibitor with an IC50 value of 4.5 μM. MraY-IN-2 can be used for researching anti-bacteria .
|
-
- HY-111331
-
|
|
Antibiotic
Hexokinase
|
Infection
|
|
Germicidin B is an antibiotic with bactericidal properties. Germicidin B can inhibit hexokinase II, with an IC50 of 25.16 μM .
|
-
- HY-P5720
-
|
|
Bacterial
|
Infection
|
|
Peptide 5e is an antimicrobial peptide. Peptide 5e inhibits E. coli, S. aureus, and C. albicans with MIC values of 30, 5, 25 μg/mL respectively .
|
-
- HY-78542
-
-
- HY-W012836S2
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
4-Ethylphenol-d2 is deuterated labeled Isoeugenol (HY-N1952). Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively .
|
-
- HY-172945
-
|
|
Bacterial
|
Infection
|
|
LpxC-IN-16 (Compound P-2) is an LpxC inhibitor. LpxC-IN-16 has anti-MDR P. aeruginosa activity .
|
-
- HY-B0269
-
-
- HY-169160
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death .
|
-
- HY-P5698
-
|
|
Bacterial
|
Infection
|
|
Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .
|
-
- HY-B0269R
-
|
DL 473 (Standard); Cyclopentylrifampicin (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Rifapentine (Standard) is the analytical standard of Rifapentine. This product is intended for research and analytical applications. Rifapentine (DL 473) is an antibiotic used in tuberculosis research .
|
-
- HY-113784R
-
|
Isoxyl (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
β-Cyclodextrin (Standard) is the analytical standard of β-Cyclodextrin. This product is intended for research and analytical applications. β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
|
-
- HY-127160R
-
|
|
Parasite
Bacterial
Reference Standards
|
Infection
|
|
Benzoxonium (chloride) (Standard) is the analytical standard of Benzoxonium (chloride). This product is intended for research and analytical applications. Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
|
-
- HY-100385R
-
|
Cyclo(L-Pro-L-Trp) (Standard)
|
Reference Standards
PI3K
Bacterial
|
Infection
|
|
Rebaudioside C (Standard) is the analytical standard of Rebaudioside C. This product is intended for research and analytical applications. Rebaudioside C (Dulcoside B) is a natural sweetener that can be used in controlled diets for diabetic patients.
|
-
- HY-P2962
-
|
TG
|
Biochemical Assay Reagents
|
Infection
Inflammation/Immunology
|
|
Transglutaminase, Streptoverticillium mobaraense (TG) is an enzyme that forms cross-links between protein molecules. Transglutaminase, Streptoverticillium mobaraense attaches proteins and peptides to small molecules, polymers, surfaces, DNA and other proteins. Transglutaminase, Streptoverticillium mobaraense is widely used in food applications in the meat, fish, dairy and baking industries .
|
-
- HY-P5705
-
|
|
Fungal
Bacterial
|
Infection
|
|
Gageotetrin B has antimicrobial activities. Gageotetrin B is more active against fungi compared to bacteria with MIC values of 0.01-0.04 μM .
|
-
- HY-163906
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 16 (Compound 4) is an inhibitor of methicillin-resistant Staphylococcus aureus (MRSA). Anti-MRSA agent 16 is effective in combination with oxacillin or meropenem in infected mice .
|
-
- HY-P5700
-
|
|
Bacterial
|
Infection
|
|
SAAP Fraction 3 is an antimicrobial peptide. SAAP Fraction 3 is active against P. haemolytica in Zn-saline buffer .
|
-
- HY-107213
-
-
- HY-150330
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
DNA ligase-IN-1 (Compound 1) is an inhibitor of bacterial NAD +-dependent DNA ligase (LigA). DNA ligase-IN-1 effectively inhibits the growth of Staphylococcus aureus in vitro .
|
-
- HY-P5730
-
|
|
Bacterial
|
Infection
|
|
Peptide 5g is an antimicrobial peptide. Peptide 5g inhibits E. coli, S. aureus, and C. albicans with MIC values of 30, 10, 12.5 μg/mL respectively .
|
-
- HY-N10499
-
-
- HY-P5707
-
-
- HY-P5699
-
|
|
Bacterial
|
Infection
|
|
Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .
|
-
- HY-B0220S3
-
|
|
Bacterial
|
Infection
|
|
Erythromycin- 13C2 is a macrolide antibiotic that can be used to treat respiratory infections, skin infections, and chlamydia infections .
|
-
- HY-B1691
-
|
Hexamine hippurate
|
Bacterial
|
Cancer
|
|
Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens .
|
-
- HY-B0289S2
-
-
- HY-W007056
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .
|
-
- HY-N3075
-
-
- HY-125633
-
|
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Kapurimycin A3 is an antitumor and antibacterial antibiotic. Kapurimycin A3 has DNA binding and breakage activity. Kapurimycin A3 can be isolated from Streptomyces .
|
-
- HY-N14880
-
|
|
Antibiotic
Bacterial
|
Infection
Cardiovascular Disease
|
|
Oudenone is an oxygen-containing heterocyclic antibiotic. Oudenone has weak antibacterial and fungal activity. Oudenone has antihypertensive effect on spontaneous hypertension in rats by intraperitoneal injection or oral administration .
|
-
- HY-126460
-
|
|
Biochemical Assay Reagents
Bacterial
|
Infection
Others
|
|
Myristoyl glutamic acid is a myristoyl glutamic acid. Myristoyl glutamic acid is an amino acid surfactant, which can be used as cleansers, foaming agents in the cosmetic industry. Myristoyl glutamic acid shows a slight antibacterial effect .
|
-
- HY-B1297
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Ceforanide is a semisynthetic parental cephalosporin antibiotic, derived from 7-aminocephalosporanic acid. Ceforanide has antibacterial activity and is a potent inhibitor of most species of streptococci, excluding enterococci .
|
-
- HY-136943
-
|
|
Antibiotic
Parasite
Bacterial
|
Infection
|
|
K-41 is an orally active antibiotic. K-41 can be obtained from Streptomyces hygroscopicus. K-41 has antibacterial and antiplasmodial activity .
|
-
- HY-N14091
-
|
|
Bacterial
|
Infection
|
|
Chrysospermin D has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-119646
-
|
ABG-3168 free base
|
Glutathione S-transferase
|
Others
|
|
Aviglycine (ABG-3168 free base) is an inhibitor of ethylene biosynthesis with antibacterial activity. Aviglycine (ABG-3168 (free base)) application delays natural flowering in pineapple .
|
-
- HY-W354851
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Pisiferic acid is an antibacterial agent with inhibitory activity against Gram-negative/positive bacteria such as P. vulgaris, S. aureus and B. subtilis. Pisiferic acid can be used to study bacterial infections .
|
-
- HY-123922
-
|
|
Bacterial
|
Infection
|
|
NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties .
|
-
- HY-N3907
-
|
|
Bacterial
|
Infection
|
|
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
|
-
- HY-152091
-
|
|
Fungal
|
Infection
Cancer
|
|
Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .
|
-
- HY-N14090
-
|
|
Bacterial
|
Infection
|
|
Chrysospermin C has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-138650
-
|
Glyceryl monocaprylate; Sefsol 318
|
Bacterial
|
Inflammation/Immunology
|
|
Monocaprylin (Glyceryl monocaprylate), a monoglyceride of caprylic acid, exhibits an excellent antibacterial activity. Monocaprylin inhibits a variety of foodborne pathogenic and spoilage microorganisms and has the potential for an alternative food preservative research .
|
-
- HY-N14089
-
|
|
Bacterial
|
Infection
|
|
Chrysospermin B has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-167714
-
|
|
Others
|
Infection
|
|
Cefazaflur is a novel semi-synthetic cephalosporin derivative that exhibits significant antibacterial activity, effectively inhibiting various strains of Staphylococcus aureus, Escherichia coli, Klebsiella, and Proteus mirabilis at low concentrations.
|
-
- HY-N10608
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
(-)-Isoledene is a natural organic compound with antibacterial and anti-inflammatory activities. (-)-Isoledene has also been studied for the synthesis of a variety of compound intermediates, demonstrating its potential application in compound development.
|
-
- HY-W705651
-
-
- HY-N6656
-
|
|
Fungal
Bacterial
|
Inflammation/Immunology
Cancer
|
|
6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity .
|
-
- HY-N3912
-
|
|
Bacterial
|
Infection
Cancer
|
|
Furomollugin is a natural product with antioxidant and antibacterial activities, can be isolated from Rubia cordifolia. Furomollugin lacks potent anti-tyrosinase activity, but also exhibits significant anticancer property .
|
-
- HY-30235AR
-
|
|
Reference Standards
PGE synthase
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Benzydamine (hydrochloride) (Standard) is the analytical standard of Benzydamine (hydrochloride). This product is intended for research and analytical applications. Benzydamine hydrochloride is a prostaglandin synthase inhibitor, anti-inflammatory, and has also been reported to have antibacterial activity.
|
-
- HY-B1119S
-
|
|
Bacterial
Fungal
Autophagy
Antibiotic
|
Infection
Cancer
|
|
Triclosan-d3 is the deuterium labeled Triclosan. Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments .
|
-
- HY-N10229
-
|
|
Fungal
|
Infection
|
|
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .
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- HY-W002751
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Drug Intermediate
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Others
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6-Methylsalicylic acid is the secondary metabolite that could be isolated from some fungi. 6-Methylsalicylic acid can be used as building blocks for synthesis of antibacterial and anti-inflammatory agents .
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- HY-122588
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Bacterial
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Others
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Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons.
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- HY-121620R
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Bacterial
SARS-CoV
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Infection
Inflammation/Immunology
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Monolaurin (Standard) is the analytical standard of Monolaurin. This product is intended for research and analytical applications. Monolaurin (1-Monolaurin) is an orally active antibiotic with antiviral and antibacterial properties .
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- HY-10882S
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- HY-W016473
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Bacterial
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Infection
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Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
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- HY-172962
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DNA/RNA Synthesis
Bacterial
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Infection
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DNA Gyrase-IN-17 (Compound 5C) is a DNA Gyrase inhibitor. DNA Gyrase-IN-17 exhibits significant antibacterial activity against a variety of Gram-positive and Gram-negative strains (such as Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, etc.), with a MIC value of 62.5 μg/mL. DNA Gyrase-IN-17 interferes with DNA replication by inhibiting bacterial DNA gyrase. DNA Gyrase-IN-17 can be used in the development of antibacterial drugs, especially for the study of drug-resistant strains .
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- HY-B0200AR
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Cefalexin hydrochloride (Standard); Cephacillin hydrochloride (Standard)
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Penicillin-binding protein (PBP)
Reference Standards
Bacterial
Antibiotic
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Infection
Cancer
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Cephalexin (hydrochloride) (Standard) is the analytical standard of Cephalexin (hydrochloride). This product is intended for research and analytical applications. Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].
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- HY-B0200BR
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Cefalexin hydrate (Standard); Cephacillin hydrate (Standard)
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Penicillin-binding protein (PBP)
Reference Standards
Antibiotic
Bacterial
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Infection
Cancer
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Cephalexin (monohydrate) (Standard) is the analytical standard of Cephalexin (monohydrate). This product is intended for research and analytical applications. Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .
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- HY-B1158
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Bacterial
Mas-related G-protein-coupled Receptor (MRGPR)
Interleukin Related
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Infection
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Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells .
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- HY-113764
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