Search Result
Results for "
antiinflammatory
" in MCE Product Catalog:
1518
Inhibitors & Agonists
2
Biochemical Assay Reagents
199
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
-
- HY-146547
-
|
Anti-inflammatory agent 17
|
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).
|
-
- HY-147769
-
|
Anti-inflammatory agent 23
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 23 (Compound 4m) is an anti-inflammatory agent. Anti-inflammatory agent 23 inhibits the production of NO activated by LPS with an IC50 of 0.449 μM. Anti-inflammatory agent 23 has a good affinity for p65 protein.
|
-
- HY-146435
-
|
Anti-inflammatory agent 22
|
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice.
|
-
- HY-N10436
-
-
- HY-N10435
-
-
- HY-N10434
-
-
- HY-143410
-
-
- HY-U00273
-
-
- HY-146419
-
|
Anti-inflammatory agent 20
|
NF-κB
COX
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation.
|
-
- HY-146421
-
|
Anti-inflammatory agent 21
|
NO Synthase
NF-κB
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.
|
-
- HY-145870
-
|
Anti-inflammatory agent 13
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation.
|
-
- HY-115922
-
|
Anti-inflammatory agent 10
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 10 (compound 30) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 10 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 10 is orally active.
|
-
- HY-115921
-
|
Anti-inflammatory agent 9
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 9 (compound 28) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 9 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 9 is orally active.
|
-
- HY-144737
-
|
Anti-inflammatory agent 15
|
Bacterial
TNF Receptor
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.
|
-
- HY-144727
-
|
Anti-inflammatory agent 11
|
Bacterial
TNF Receptor
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research.
|
-
- HY-150587
-
|
Anti-inflammatory agent 31
|
ERK
NF-κB
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.
|
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- HY-115920
-
|
Anti-inflammatory agent 8
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active.
|
-
- HY-145869
-
|
Anti-inflammatory agent 12
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC50 value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease.
|
-
- HY-144735
-
-
- HY-143456
-
|
Anti-inflammatory agent 18
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
|
-
- HY-143457
-
|
Anti-inflammatory agent 19
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
|
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- HY-139833
-
-
- HY-N10066
-
-
- HY-139844
-
-
- HY-106555
-
|
Protizinic acid
|
Phospholipase
|
Inflammation/Immunology
|
|
Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM.
|
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- HY-N0007A
-
-
- HY-N7148
-
|
γ-Tocopherol
D-γ-Tocopherol; (+)-γ-Tocopherol
|
COX
|
Cancer
Inflammation/Immunology
|
|
γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.
|
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- HY-N2556
-
|
Tirucallol
|
Others
|
Inflammation/Immunology
|
|
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages.
|
-
- HY-107410
-
|
SC-26196
|
Others
|
Inflammation/Immunology
|
|
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties.
|
-
- HY-123352
-
|
ZK 216348
(+)-ZK 216348
|
Glucocorticoid Receptor
|
Endocrinology
Inflammation/Immunology
|
|
ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects.
|
-
- HY-B0727
-
|
Betamethasone valerate
Betamethasone 17-valerate
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone ( 3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively.
|
-
- HY-P2136
-
-
- HY-125703
-
|
Ferutinin
|
Estrogen Receptor/ERR
Apoptosis
|
Cancer
Infection
Endocrinology
Inflammation/Immunology
|
|
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.
|
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- HY-A0027
-
-
- HY-A0027A
-
|
Fenspiride
|
Histamine Receptor
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases.
|
-
- HY-N0013
-
-
- HY-125911
-
|
Gossypin
|
NF-κB
|
Cancer
Inflammation/Immunology
Cardiovascular Disease
|
|
Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro.
|
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- HY-N7044
-
-
- HY-N3032
-
|
Xanthatin
|
Apoptosis
VEGFR
Lipoxygenase
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Xanthatin is isolated from Xanthium strumarium leaves. Xanthatin exhibits strong antitumor activities against a variety of cancer cells through apoptosis persuasion and shows anti-inflammatory activities by inhibiting PGE2 synthesis and 5-lipoxygenase activity. Xanthatin is a potent and orally active inhibitor of VEGFR2 kinase activity with an IC50 of 3.8 μM and prominently blocks the phosphorylation of VEGFR2 at Tyr951 site. Xanthatin inhibits angiogenesis and has the potential for the investigation of breast cancer.
|
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- HY-13628
-
|
Etalocib
LY293111; VML 295
|
Leukotriene Receptor
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [ 3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.
|
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- HY-N0033
-
-
- HY-133870
-
|
Itaconate-alkyne
ITalk
|
Others
|
Inflammation/Immunology
|
|
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate.
|
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- HY-135676
-
-
- HY-135675
-
-
- HY-106567
-
|
Fluocortin butyl ester
|
Others
|
Inflammation/Immunology
|
|
Fluocortin butyl ester is a developed corticosteroid compound with no detectable systemic corticosteroid activity when it is used topically. Fluocortin butyl ester appears to be an effective well-tolerated topical steroid useful in the research of perennial rhinitis.
|
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- HY-135677
-
-
- HY-135678
-
-
- HY-135679
-
-
- HY-N9312
-
-
- HY-105939
-
|
Isofezolac
LM 22070
|
PGE synthase
|
Inflammation/Immunology
|
|
Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties.
|
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- HY-N7700
-
-
- HY-B1137
-
|
Ramifenazone
Isopropylaminoantipyrine
|
Others
|
Inflammation/Immunology
|
|
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities.
|
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- HY-101642
-
-
- HY-B0634
-
|
Aceclofenac
|
COX
|
Inflammation/Immunology
|
|
Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
|
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- HY-17350
-
-
- HY-100139
-
-
- HY-B2113
-
-
- HY-101751
-
-
- HY-U00081
-
-
- HY-144773A
-
-
- HY-W015820
-
|
Phthalide
|
Others
|
Inflammation/Immunology
|
|
Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant.
|
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- HY-B1203
-
-
- HY-100286
-
-
- HY-U00100
-
-
- HY-100146
-
-
- HY-111392
-
-
- HY-B1047
-
-
- HY-101655
-
|
COX-2-IN-2
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
|
-
- HY-137394
-
|
Nicotredole
Tryptamide
|
Others
|
Inflammation/Immunology
|
|
Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.
|
-
- HY-119684
-
|
Maresin 2
|
Others
|
Inflammation/Immunology
|
|
Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages.
|
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- HY-W050088
-
|
Isoxepac
HP 549
|
Others
|
Inflammation/Immunology
|
|
Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc.
|
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- HY-17476
-
-
- HY-B0288B
-
-
- HY-N2988A
-
-
- HY-109098
-
-
- HY-B0288A
-
-
- HY-N10276
-
-
- HY-U00024
-
-
- HY-U00098
-
-
- HY-14937
-
-
- HY-N3587
-
-
- HY-106579
-
|
Tiaprofenic acid
|
COX
|
Inflammation/Immunology
|
|
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.
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- HY-N1954
-
|
Protostemonine
|
Others
|
Inflammation/Immunology
|
|
Protostemonine is an active alkaloid mainly isolated from the roots of Stemona sesslifolia, with anti-inflammatory activity. Protostemonine has anti-inflammatory effects on asthma and gram-negative bacteria-induced acute lung injury.
|
-
- HY-17485
-
|
Alminoprofen
EB-382
|
Phospholipase
COX
|
Inflammation/Immunology
|
|
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
|
-
- HY-106628
-
|
Sudoxicam
|
COX
|
Inflammation/Immunology
|
|
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.
|
-
- HY-15028
-
|
Otenaproxesul
ATB-346
|
COX
Apoptosis
|
Inflammation/Immunology
|
|
Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities.
|
-
- HY-116015
-
-
- HY-N1965
-
|
Gaultherin
|
Others
|
Inflammation/Immunology
|
|
Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin.
|
-
- HY-128695
-
-
- HY-13571
-
-
- HY-U00350
-
-
- HY-N0213
-
-
- HY-B0645
-
-
- HY-U00043
-
-
- HY-B1383
-
-
- HY-N2030
-
-
- HY-111950
-
|
(-)-Ibuprofenamide
(R)-Ibuprofenamide
|
Others
|
Inflammation/Immunology
|
|
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-B0634S
-
|
Aceclofenac-d4
|
COX
|
Inflammation/Immunology
|
|
Aceclofenac-d4 is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
|
-
- HY-17463
-
|
Prednisolone
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Endocrinology
|
|
Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
|
-
- HY-17361
-
|
Etofenamate
|
COX
|
Inflammation/Immunology
|
|
Etofenamate, a non-steroid anti-inflammatory drug (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
|
-
- HY-N0875
-
-
- HY-N4312
-
-
- HY-W173309
-
-
- HY-B0248
-
-
- HY-N0725
-
-
- HY-B1900
-
-
- HY-N5116
-
-
- HY-N0212
-
|
Peimine
Verticine; Dihydroisoimperialine
|
Others
|
Inflammation/Immunology
|
|
Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
|
-
- HY-103672
-
-
- HY-N6941
-
-
- HY-N0741A
-
-
- HY-N2123
-
-
- HY-N0741
-
-
- HY-B0440
-
-
- HY-U00169
-
-
- HY-B0270
-
-
- HY-103385
-
|
NCX4040
NO-Aspirin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects.
|
-
- HY-100977
-
-
- HY-N0559
-
-
- HY-P1539
-
-
- HY-N0181
-
-
- HY-N0056
-
-
- HY-N3472
-
-
- HY-17484
-
-
- HY-B1013
-
-
- HY-N10210
-
-
- HY-N0813
-
-
- HY-14579
-
-
- HY-N2352A
-
-
- HY-N2271
-
-
- HY-17463S
-
|
Prednisolone-d8
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Endocrinology
|
|
Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research.
|
-
- HY-B0482
-
|
Acemetacin
TVX 1322
|
COX
|
Inflammation/Immunology
|
|
Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-N2516
-
-
- HY-17481
-
-
- HY-N0007
-
-
- HY-B1179
-
-
- HY-19017
-
-
- HY-N8534
-
-
- HY-B0641
-
-
- HY-N9451
-
-
- HY-122267A
-
-
- HY-14857
-
-
- HY-B0174
-
-
- HY-N8197
-
-
- HY-N2854
-
-
- HY-B1104
-
-
- HY-108281
-
-
- HY-107208
-
-
- HY-N10120
-
-
- HY-N2151
-
-
- HY-N9400
-
-
- HY-111354
-
-
- HY-101581
-
|
Bucloxic acid
804CB; Bucloxonic acid; Esfar
|
Others
|
Inflammation/Immunology
|
|
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
|
-
- HY-14916
-
-
- HY-U00048
-
-
- HY-N2152
-
-
- HY-N2154
-
-
- HY-32343
-
-
- HY-B0386
-
-
- HY-120824
-
|
Mofezolac
|
COX
|
Inflammation/Immunology
|
|
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities.
|
-
- HY-17361S
-
|
Etofenamate-d4
|
COX
|
Inflammation/Immunology
|
|
Etofenamate-d4 is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory drug (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
|
-
- HY-19384
-
|
Enflicoxib
E 6087
|
COX
|
Inflammation/Immunology
|
|
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.
|
-
- HY-N0101
-
-
- HY-N8038
-
|
Isoanthricin
(Rac)-Deoxypodophyllotoxin
|
Others
|
Others
|
|
Isoanthricin ((Rac)-Deoxypodophyllotoxin) is the racemate of Deoxypodophyllotoxin. Deoxypodophyllotoxin is a potent antitumor and anti-inflammatory agent.
|
-
- HY-17625
-
-
- HY-N1921
-
-
- HY-N10112
-
-
- HY-N8149
-
-
- HY-N0272
-
-
- HY-B0485
-
-
- HY-150002
-
-
- HY-B1203S1
-
|
Fludrocortisone-d2
9α-Fludrocortisone-d2; 9α-Fluorcortisol-d2
|
Mineralocorticoid Receptor
|
|
|
Fludrocortisone-d2 is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.
|
-
- HY-N4290
-
-
- HY-N6804
-
-
- HY-N3125
-
-
- HY-N0662
-
-
- HY-W173220
-
-
- HY-B0878
-
|
Halobetasol (propionate)
BMY-30056; CGP-14458; Ulobetasol propionate
|
Others
|
Others
|
|
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.
|
-
- HY-N9375
-
-
- HY-N7976
-
-
- HY-N2052
-
-
- HY-N6948
-
-
- HY-N7903
-
-
- HY-N2855
-
|
Alphitolic acid
Aophitolic acid
|
Apoptosis
Autophagy
TNF Receptor
Akt
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.
|
-
- HY-N0759
-
-
- HY-N6039
-
-
- HY-B0494
-
-
- HY-N3017
-
-
- HY-108280
-
-
- HY-Y1362
-
-
- HY-N6827
-
-
- HY-N2965
-
-
- HY-17509
-
-
- HY-76225
-
|
Ammonium glycyrrhizinate
Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate
|
Others
|
Inflammation/Immunology
|
|
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
|
-
- HY-N2441
-
-
- HY-N0228
-
-
- HY-131118
-
-
- HY-125131
-
-
- HY-147247
-
-
- HY-N0423
-
-
- HY-121235
-
-
- HY-14445
-
-
- HY-N2437
-
-
- HY-101482
-
-
- HY-N2302
-
-
- HY-N0370
-
-
- HY-B1214
-
-
- HY-Y0189
-
|
Methyl Salicylate
Wintergreen oil
|
COX
|
Inflammation/Immunology
|
|
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor.
|
-
- HY-135731
-
|
4-Methylamino antipyrine
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.
|
-
- HY-17485S
-
|
Alminoprofen-d3
EB-382-d3
|
Phospholipase
COX
|
Inflammation/Immunology
|
|
Alminoprofen-d3 (EB-382-d3) is the deuterium labeled Alminoprofen. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
|
-
- HY-135731A
-
|
4-Methylamino antipyrine hydrochloride
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
|
-
- HY-N2035
-
-
- HY-N1981
-
-
- HY-N9834
-
-
- HY-N0719
-
-
- HY-B0625
-
-
- HY-N2114
-
-
- HY-13075
-
-
- HY-N1089
-
-
- HY-119517
-
-
- HY-N7083
-
-
- HY-14398
-
-
- HY-104015
-
-
- HY-N0576
-
-
- HY-N0362
-
-
- HY-130046
-
-
- HY-B0367
-
-
- HY-B1832
-
-
- HY-N3544
-
-
- HY-101481
-
-
- HY-N5010
-
-
- HY-N9388
-
-
- HY-U00063
-
-
- HY-14938
-
-
- HY-19025
-
-
- HY-P1572
-
-
- HY-104025
-
-
- HY-107831
-
-
- HY-17629
-
-
- HY-105028
-
|
Tenidap
CP-66248
|
COX
|
Inflammation/Immunology
|
|
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-133159
-
-
- HY-N4137
-
-
- HY-114771
-
-
- HY-N4146
-
-
- HY-N0516
-
|
Casticin
Vitexicarpin
|
STAT
|
Inflammation/Immunology
|
|
Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
|
-
- HY-N2263
-
|
Skimmin
Umbelliferone glucoside
|
Others
|
Inflammation/Immunology
|
|
Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity.
|
-
- HY-N2012
-
-
- HY-N0628
-
-
- HY-W008613
-
-
- HY-W013331
-
-
- HY-N1178
-
-
- HY-U00187
-
|
NCX1022
|
Others
|
Inflammation/Immunology
|
|
NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory drug for the treatment of skin inflammation.
|
-
- HY-B1153A
-
-
- HY-N2053
-
|
Physalin L
|
NO Synthase
|
|
|
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity.
|
-
- HY-122915
-
-
- HY-139709
-
-
- HY-109082A
-
-
- HY-N0180
-
-
- HY-N2401
-
-
- HY-120007
-
-
- HY-139710
-
-
- HY-N5022
-
|
Evolitrine
7-Methoxydictamnine; Evolitrin
|
Others
|
Inflammation/Immunology
|
|
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities.
|
-
- HY-109082
-
-
- HY-N8091
-
|
Lehmannine
|
Bacterial
|
Cancer
Infection
|
|
Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities.
|
-
- HY-N1625
-
-
- HY-12384
-
|
Tenosal
|
Others
|
Inflammation/Immunology
|
|
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-U00022
-
-
- HY-105808
-
-
- HY-N0246
-
-
- HY-N2842
-
-
- HY-N9694
-
-
- HY-B0619
-
|
Zaltoprofen
CN100
|
COX
|
Inflammation/Immunology
|
|
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-N0625A
-
-
- HY-133588
-
-
- HY-N0239
-
-
- HY-N7937
-
-
- HY-116442
-
|
Azapropazone
|
Others
|
Inflammation/Immunology
|
|
Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions.
|
-
- HY-B1015
-
|
Etosalamide
Ethosalamide
|
Others
|
Inflammation/Immunology
|
|
Etosalamide (Ethosalamide) is an antipyretic and analgesic agent. Etosalamide has anti-inflammatory activity and can be used for allergic disease research.
|
-
- HY-N7036
-
-
- HY-100297
-
-
- HY-N0472
-
-
- HY-N10114
-
-
- HY-108528
-
-
- HY-N0114
-
|
Evodiamine
(+)-Evodiamine; d-Evodiamine
|
Others
|
Cancer
|
|
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
|
-
- HY-N2488
-
-
- HY-139578
-
-
- HY-B0493
-
-
- HY-N0891
-
|
Tubeimoside II
Tubeimoside-B
|
Others
|
Cancer
|
|
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
-
- HY-N0028
-
-
- HY-N7694
-
-
- HY-135658
-
-
- HY-N0512
-
|
Loganin
Loganoside
|
Apoptosis
|
Cancer
|
|
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.
|
-
- HY-15097
-
-
- HY-N6904
-
-
- HY-N2542
-
-
- HY-B1153
-
|
Glafenine
Glafenin
|
Others
|
Inflammation/Immunology
|
|
Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
|
-
- HY-N7924
-
-
- HY-B0440S
-
|
Tenoxicam-d3
Ro-12-0068-d3
|
COX
|
Inflammation/Immunology
|
|
Tenoxicam-d3 is the deuterium labeled Tenoxicam. Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.
|
-
- HY-131261
-
-
- HY-B0729
-
|
Polaprezinc
Zinc L-carnosine
|
Others
|
Inflammation/Immunology
|
|
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
|
-
- HY-N1037
-
-
- HY-N0661
-
-
- HY-N2604
-
-
- HY-A0273
-
|
Propyphenazone
4-Isopropylantipyrine; Isopropylphenazone
|
COX
|
Inflammation/Immunology
|
|
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-W031757
-
-
- HY-N0400
-
-
- HY-N2597
-
-
- HY-N1408
-
-
- HY-78131B
-
-
- HY-N0271
-
-
- HY-12383
-
|
Pelubiprofen
|
COX
|
Inflammation/Immunology
Neurological Disease
|
|
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-N0783
-
-
- HY-108249
-
|
Tribenoside
|
Others
|
Inflammation/Immunology
|
|
Tribenoside is a vasoprotective agent, can be used for the research of hemorrhoids. Tribenoside has mild anti-inflammatory, analgesic, and wound healing properties.
|
-
- HY-N0763
-
|
Angelicin
Isopsoralen
|
Apoptosis
Virus Protease
|
Cancer
|
|
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.
|
-
- HY-N0015
-
|
Astragalin
Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds.
|
-
- HY-N0924
-
|
(±)-Stylopine
Tetrahydrocoptisine
|
Others
|
Inflammation/Immunology
|
|
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.
|
-
- HY-132405S
-
-
- HY-N0476
-
|
Wilforlide A
Regelide; Abruslactone A
|
Others
|
Inflammation/Immunology
|
|
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects.
|
-
- HY-113442
-
-
- HY-N0940
-
-
- HY-N0924A
-
-
- HY-76251
-
-
- HY-121323
-
-
- HY-19217
-
-
- HY-N7697A
-
-
- HY-B0808S
-
|
Oxaprozin D4
Wy-21743 D4
|
COX
|
Others
|
|
Oxaprozin D4 (Wy-21743 D4) is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID).
|
-
- HY-N1433
-
-
- HY-B0580A
-
-
- HY-105014
-
-
- HY-13609
-
-
- HY-121076
-
-
- HY-B0008
-
-
- HY-N7643
-
-
- HY-121481
-
|
Cucurbitadienol
10α-Cucurbitadienol
|
Others
|
Inflammation/Immunology
|
|
Cucurbitadienol (10α-Cucurbitadienol) is a natural product that can be found in the seeds of Trichosanthes kirilowii. Cucurbitadienol exhibits anti-inflammatory effect.
|
-
- HY-N2909
-
|
Aurantiamide
|
Others
|
Inflammation/Immunology
|
|
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities.
|
-
- HY-B1893
-
-
- HY-B1026
-
-
- HY-137454
-
-
- HY-147811
-
-
- HY-B2191
-
|
Sodium gualenate
Guaiazulenesulfonate sodium
|
Others
|
Inflammation/Immunology
|
|
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
|
-
- HY-144773
-
-
- HY-B0482S
-
|
Acemetacin-d4
|
COX
|
Inflammation/Immunology
|
|
Acemetacin-d4 is the deuterium labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-N2367
-
-
- HY-N0570
-
-
- HY-N0748
-
-
- HY-103325
-
-
- HY-N6244
-
|
Isolindleyin
|
Tyrosinase
|
Inflammation/Immunology
|
|
Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.
|
-
- HY-17480
-
|
Bendazac
|
Others
|
Inflammation/Immunology
|
|
Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties. Bendazac acts by preventing protein denaturation and delays the cataractogenic process.
|
-
- HY-N3408
-
|
Lamiide
|
Others
|
Inflammation/Immunology
|
|
Lamiide, an orally active iridoid compound, can be found in Bouchea fluminensis leaves. Lamiide exhibits anti-inflammatory and anti-lipoperoxidative activity.
|
-
- HY-135301
-
-
- HY-N7993
-
-
- HY-N3509
-
|
Hyponine E
(-)-Hyponine E
|
Others
|
Inflammation/Immunology
|
|
Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects.
|
-
- HY-B1046
-
-
- HY-13219
-
-
- HY-N0708
-
-
- HY-N10423
-
|
Cubebin
(-)-Cubebin
|
Others
|
Inflammation/Immunology
|
|
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity.
|
-
- HY-N2601
-
-
- HY-N2276
-
|
Nodakenetin
|
Others
|
Inflammation/Immunology
|
|
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic.
|
-
- HY-N0263
-
|
Toosendanin
|
Others
|
Inflammation/Immunology
|
|
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.
|
-
- HY-N7931
-
-
- HY-N0222
-
|
Avicularin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities.
|
-
- HY-B0619S
-
|
Zaltoprofen-d7
|
COX
|
Inflammation/Immunology
|
|
Zaltoprofen-d7 is the deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-B0559
-
|
Nabumetone
BRL14777
|
COX
|
Inflammation/Immunology
Cancer
|
|
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.
|
-
- HY-N0006
-
-
- HY-B1203S
-
-
- HY-30235A
-
-
- HY-N6864
-
|
Isovanillic acid
3-Hydroxy-4-methoxybenzoic acid
|
Others
|
Inflammation/Immunology
|
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from S. frutescens, with Anti-inflammatory activity.
|
-
- HY-N7640
-
|
Deoxylimonin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Desoxylimonin is a triterpenoid compound isolated from grapefruit seed. Desoxylimonin derivatives has better anticancer, analgesic and anti-inflammatory activitythan the lead compound.
|
-
- HY-N0452
-
-
- HY-N3007
-
|
Naringenin chalcone
|
Others
|
Inflammation/Immunology
|
|
Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone has anti-inflammatory and antiallergic activities.
|
-
- HY-132607
-
-
- HY-B1597
-
-
- HY-N4068
-
|
Glucoraphanin
|
Reactive Oxygen Species
|
Cancer
|
|
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.
|
-
- HY-N5043
-
-
- HY-N7630
-
-
- HY-N2055
-
-
- HY-13236
-
-
- HY-D0803
-
|
Thymoquinone
|
Others
|
Inflammation/Immunology
|
|
Thymoquinone is a nature product isolated from N. sativa. Thymoquinone possess antioxidant, anti-inflammatory, anti-cancer, antitumor activities and hepatoprotective properties.
|
-
- HY-N5042
-
-
- HY-111927
-
|
Pilloin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.
|
-
- HY-N0105
-
-
- HY-N5007
-
|
Galgravin
|
Apoptosis
|
Cancer
|
|
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells.
|
-
- HY-107961
-
|
Diflorasone diacetate
|
Others
|
Inflammation/Immunology
|
|
Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses.
|
-
- HY-N7275
-
-
- HY-N1380
-
-
- HY-N2423
-
-
- HY-B1754
-
|
Rimexolone
Org 6216; Rimexel
|
Others
|
Inflammation/Immunology
|
|
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
|
-
- HY-N5015
-
|
Rosmanol
|
Others
|
Inflammation/Immunology
Cancer
|
|
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
|
-
- HY-N5089
-
-
- HY-N0021
-
-
- HY-W012634
-
-
- HY-N0207
-
-
- HY-117586
-
-
- HY-N0558
-
|
Alnustone
|
Others
|
Inflammation/Immunology
|
|
Alnustone, a non-phenolic diarylheptanoid found in herbs and spices, is a constituent of Curcuma xanthorrhiza. Alnustone displays anti-emetic and anti-inflammatory activities.
|
-
- HY-136718
-
|
CLEFMA
|
Apoptosis
|
Cancer
|
|
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
|
-
- HY-135731AS
-
|
4-Methylamino antipyrine-d3 hydrochloride
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine-d3 (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
|
-
- HY-N4150
-
|
Quercetagitrin
Quercetagetin-7-O-glucoside
|
Others
|
Inflammation/Immunology
|
|
Quercetagitrin (Quercetagetin-7-O-glucoside), isolated from the flowers of the African Marigold (Tagetes erecta), has anti-inflammatory activity.
|
-
- HY-N5003
-
-
- HY-121851
-
|
Revaprazan
SB 641257
|
Proton Pump
|
Inflammation/Immunology
|
|
Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research.
|
-
- HY-N9438
-
-
- HY-112675
-
-
- HY-N0575
-
-
- HY-132196
-
-
- HY-138558
-
-
- HY-13570A
-
-
- HY-107617
-
|
PTIQ
|
MMP
|
Neurological Disease
|
|
PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells.
|
-
- HY-N0153
-
-
- HY-W013332
-
-
- HY-N0037
-
-
- HY-W013573
-
-
- HY-17482
-
|
Difenpiramide
Z-876
|
Others
|
Inflammation/Immunology
|
|
Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity.
|
-
- HY-N6020A
-
|
(+)-Butin
|
Others
|
Others
|
|
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-125711
-
-
- HY-17509S
-
|
Deracoxib-d3
SC 046-d3; SC 46-d3; SC 59046-d3
|
COX
Apoptosis
|
Inflammation/Immunology
|
|
Deracoxib-d3 is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
|
-
- HY-N3500
-
-
- HY-W013332A
-
-
- HY-N0370S
-
|
Bergapten-d3
5-Methoxypsoralen-d3
|
Cytochrome P450
Autophagy
|
Cancer
|
|
Bergapten-d3 is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
|
-
- HY-N9615
-
-
- HY-126941
-
|
Hecogenin acetate
|
Opioid Receptor
|
Neurological Disease
|
|
Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors.
|
-
- HY-30152
-
-
- HY-N2074
-
|
Picrinine
|
Lipoxygenase
|
Inflammation/Immunology
|
|
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
|
-
- HY-13570
-
-
- HY-N7292
-
-
- HY-103662
-
-
- HY-B1355A
-
-
- HY-13751
-
-
- HY-N0436
-
|
Engeletin
|
NF-κB
|
Infection
Inflammation/Immunology
|
|
Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
|
-
- HY-N0697
-
-
- HY-128934
-
-
- HY-104026B
-
-
- HY-101737
-
-
- HY-N7697C
-
-
- HY-N2807
-
-
- HY-N0347
-
-
- HY-N8174
-
-
- HY-B0619S1
-
|
Zaltoprofen-13C,d3
|
COX
|
Inflammation/Immunology
|
|
Zaltoprofen-13C,d3 is the 13C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-129611
-
|
Bromelain
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
|
-
- HY-105028S
-
|
Tenidap-d3
CP-66248-d3
|
COX
|
Inflammation/Immunology
|
|
Tenidap-d3 (CP-66248-d3) is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-147105
-
|
LRH-1 modulator-1
|
Others
|
Inflammation/Immunology
|
|
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa.
|
-
- HY-N0068
-
-
- HY-N2406
-
-
- HY-B1453
-
-
- HY-121046S
-
|
Flunixin-d3
|
COX
|
Inflammation/Immunology
|
|
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
|
-
- HY-N2083
-
|
Handelin
|
NF-κB
|
Inflammation/Immunology
|
|
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production.
|
-
- HY-N6020
-
|
(-)-Butin
|
Others
|
Inflammation/Immunology
|
|
(-)-Butin is the S enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-U00157
-
|
Meseclazone
W2395; NSC297623
|
Others
|
Inflammation/Immunology
|
|
Meseclazone (W2395;NSC297623) exhibits inhibitory potency of secondary phase ADP aggregation. Meseclazone possesses anti-inflammatory, analgesic and antipyretic activity.
|
-
- HY-13772
-
|
Valrubicin
AD-32
|
PKC
|
Cancer
Inflammation/Immunology
|
|
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.
|
-
- HY-17492
-
-
- HY-W019940
-
-
- HY-N9315
-
-
- HY-N0023
-
|
Cistanoside A
|
NO Synthase
|
Inflammation/Immunology
|
|
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect.
|
-
- HY-N4322
-
-
- HY-N1981S1
-
|
Triolein-d5
|
MMP
Endogenous Metabolite
|
|
|
Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties.
|
-
- HY-Z0548
-
-
- HY-137992
-
|
Aucuparin
|
Others
|
Inflammation/Immunology
|
|
Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. Anti-inflammatory activity.
|
-
- HY-N0474
-
-
- HY-N7067
-
|
Revaprazan hydrochloride
|
Bacterial
COX
|
Infection
|
|
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection.
|
-
- HY-107470
-
-
- HY-N0493
-
-
- HY-126296
-
-
- HY-B0625S
-
-
- HY-12840
-
-
- HY-N7190
-
|
Yadanzioside F
|
Others
|
Cancer
|
|
Yadanzioside F is one of the toxic components found in Brucea javanica. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties.
|
-
- HY-N2149A
-
-
- HY-N2149
-
-
- HY-N10454
-
-
- HY-N0812
-
-
- HY-N0826
-
-
- HY-N10453
-
-
- HY-N0344
-
-
- HY-N0401
-
-
- HY-147963
-
|
COX-2-IN-24
|
COX
|
Infection
|
|
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
|
-
- HY-139199
-
|
4-Hydroxyphenylbutazone
|
Drug Metabolite
|
Others
|
|
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
|
-
- HY-N7697D
-
-
- HY-N0779A
-
|
Silybin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
|
-
- HY-N6878
-
|
Cauloside D
|
Others
|
Inflammation/Immunology
|
|
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-N0804
-
|
Narirutin
|
Bacterial
|
Inflammation/Immunology
|
|
Narirutin, one of the active constituents isolated from Citrus unshiu, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency.
|
-
- HY-N1429
-
-
- HY-N0795
-
-
- HY-N0017
-
-
- HY-W004294
-
-
- HY-B0972
-
|
Cinchophen
|
Bacterial
|
Inflammation/Immunology
|
|
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
|
-
- HY-N6829
-
|
Retusin
Quercetin-3,3',4',7-tetramethylether
|
Others
|
Infection
Inflammation/Immunology
|
|
Retusin (Quercetin-3,3',4',7-tetramethylether), a natural compound isolated from the leaves of Talinum triangulare, possesses antiviral and anti-inflammatory activities.
|
-
- HY-N1181
-
-
- HY-N0564
-
-
- HY-N4111
-
-
- HY-N2189
-
-
- HY-N2027
-
-
- HY-N6919
-
|
Cauloside C
|
Others
|
Inflammation/Immunology
|
|
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-107632
-
-
- HY-13751A
-
-
- HY-B1616
-
-
- HY-N0297S
-
|
Sinensetin-d3
|
PGE synthase
TNF Receptor
|
Others
|
|
Sinensetin-d3 is the deuterium labeled Sinensetin. Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
|
-
- HY-Y0148
-
-
- HY-N0399
-
-
- HY-N7176
-
|
Kaempferol 3-O-β-D-glucuronide
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Inflammation/Immunology
|
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.
|
-
- HY-B0808A
-
|
Oxaprozin potassium
Oxaprozinum potassium; Wy21743 potassium
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-12383S
-
|
Pelubiprofen-13C,d3
|
COX
|
Inflammation/Immunology
Neurological Disease
|
|
Pelubiprofen-13C,d3 is the 13C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-B0808
-
|
Oxaprozin
Oxaprozinum; Wy21743
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-B1121
-
-
- HY-B1042
-
|
Oxolamine citrate
SKF-9976 citrate; AF-438 citrate
|
Others
|
Inflammation/Immunology
|
|
Oxolamine citrate (SKF-9976 citrate) is a cough suppressant that can be used for the research of respiratory tract diseases. Oxolamine citrate also exhibits anti-inflammatory effect.
|
-
- HY-B0261
-
-
- HY-32291
-
|
Methyl L-pyroglutamate
(S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
|
Others
|
Others
|
|
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
|
-
- HY-Y0073
-
|
4-Hydroxyacetophenone
P-hydroxyacetophenone
|
HBV
|
Infection
Inflammation/Immunology
|
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect.
|
-
- HY-N6049
-
-
- HY-N0363
-
|
(+)-Columbianetin
(S)-Columbianetin
|
Others
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-17490
-
|
Oxaceprol
N-Acetyl-L-hydroxyproline
|
Others
|
Inflammation/Immunology
|
|
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
|
-
- HY-136203
-
-
- HY-113556
-
-
- HY-B0289
-
-
- HY-N0007S
-
|
Bisdemethoxycurcumin-d8
Curcumin III-d8; Didemethoxycurcumin-d8
|
Apoptosis
Autophagy
|
Cancer
|
|
Bisdemethoxycurcumin-d8 (Curcumin III-d8) is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
|
-
- HY-N1981S
-
-
- HY-N0114A
-
-
- HY-N10297
-
-
- HY-121362
-
-
- HY-N7036S
-
|
Rhamnetin-d3
|
Phospholipase
|
Inflammation/Immunology
|
|
Rhamnetin-d3 is the deuterium labeled Rhamnetin. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2, with antioxidant and anti-inflammatory activity.
|
-
- HY-103386
-
|
FR122047
|
COX
|
Inflammation/Immunology
|
|
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo.
|
-
- HY-N2281
-
-
- HY-N8096
-
|
Raddeanoside R17
Pulchinenoside E3
|
Others
|
Inflammation/Immunology
|
|
Raddeanoside R17 (Pulchinenoside E3) is a saponin compound that can be isolated from the root of Pulsatilla koreana. Raddeanoside R17 shows anti-inflammatory effects.
|
-
- HY-N1109
-
|
Uvaol
|
Others
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.
|
-
- HY-122402
-
|
Umirolimus
|
Others
|
Inflammation/Immunology
|
|
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used drug-eluting stent (DES) applications.
|
-
- HY-N2543
-
-
- HY-N0635
-
-
- HY-18342
-
|
Diflunisal
MK-647
|
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-136204
-
-
- HY-B1130
-
|
Isoxicam
|
COX
|
Inflammation/Immunology
|
|
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam is a nonselective inhibitor of COX-1 and COX-2.
|
-
- HY-B0260
-
-
- HY-125938
-
|
Cycloartenyl ferulate
Cycloartenol ferulate; Cycloartenol ferulic acid ester
|
Others
|
Cancer
Inflammation/Immunology
|
|
Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities.
|
-
- HY-N2270
-
-
- HY-107591
-
|
PF-184
|
IKK
|
Inflammation/Immunology
|
|
PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. PF-184 has anti-inflammatory effects.
|
-
- HY-N0115
-
-
- HY-N2473
-
-
- HY-10448
-
-
- HY-N6656
-
-
- HY-A0273S
-
|
Propyphenazone-d3
|
COX
|
Inflammation/Immunology
|
|
Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-N8253
-
|
Spiraeoside
Quercetin 4′-O-glucoside
|
Reactive Oxygen Species
|
Cancer
Inflammation/Immunology
|
|
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.
|
-
- HY-B1121A
-
-
- HY-B2114
-
|
Escin
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Escin, a natural compound of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
|
-
- HY-N0639
-
|
Punicalin
|
HBV
|
Infection
Inflammation/Immunology
|
|
Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity.
|
-
- HY-113334
-
-
- HY-N1382
-
|
Asperuloside
|
NO Synthase
|
Inflammation/Immunology
|
|
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.
|
-
- HY-129060
-
|
Flutrimazole
|
Fungal
|
Infection
|
|
Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
|
-
- HY-117726
-
-
- HY-N2266
-
-
- HY-13609S1
-
-
- HY-100599
-
-
- HY-N2014
-
|
Verbenalin
|
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Verbenalin is Verbena glycoside, with anti-inflammatory, anti-fungal anti-virus activities. Verbenalin can be used for the research of prostatitis. Verbenalin can reduce cerebral ischemia-reperfusion injury.
|
-
- HY-N6065
-
|
Praeruptorin A
|
NF-κB
|
Inflammation/Immunology
|
|
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation.
|
-
- HY-N6806
-
-
- HY-B0138
-
|
Ketorolac tromethamine salt
Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt
|
COX
|
Inflammation/Immunology
|
|
Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-B0008S
-
-
- HY-107203
-
-
- HY-13324
-
|
Bardoxolone methyl
RTA 402; NSC 713200; CDDO Methyl ester
|
Keap1-Nrf2
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway.
|
-
- HY-130494
-
-
- HY-N2555
-
-
- HY-135654
-
-
- HY-N2081
-
|
Skimmianine
|
Others
|
Cancer
Inflammation/Immunology
|
|
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity.
|
-
- HY-N7688
-
-
- HY-107795
-
-
- HY-B0712
-
|
Ceftriaxone
|
Bacterial
Antibiotic
|
Infection
|
|
Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-N0133
-
|
Tangeretin
Tangeritin; NSC53909; NSC618905
|
Notch
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.
|
-
- HY-N2162
-
|
12-Epinapelline
|
Others
|
Inflammation/Immunology
|
|
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors.
|
-
- HY-N0363A
-
|
(+)-Columbianetin acetate
(S)-Columbianetin acetate
|
Others
|
Infection
Inflammation/Immunology
|
|
(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-N3006
-
|
Sakuranetin
|
Fungal
|
Infection
Inflammation/Immunology
|
|
Sakuranetin is a rice flavonoid phytoalexin, shows strong antifungal activity. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury.
|
-
- HY-N2989
-
-
- HY-N2065
-
|
Withaferin A
|
NF-κB
Ferroptosis
|
Cancer
Inflammation/Immunology
|
|
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
|
-
- HY-N1200
-
-
- HY-N6038
-
|
Gartanin
|
Fungal
Autophagy
|
Cancer
|
|
Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.
|
-
- HY-B2175
-
|
Aspirin Aluminum
Aluminum diacetylsalicylate
|
Others
|
Inflammation/Immunology
|
|
Aspirin Aluminum is a novel intermolecular compound which can inhibit gastrointestinal mucosal disorders induced by NSAIDs (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.
|
-
- HY-126121
-
-
- HY-115931
-
-
- HY-122951
-
|
Eburicoic acid
|
Others
|
Cardiovascular Disease
|
|
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. And Eburicoic acid has antidiabetic and antihyperlipidemic effects.
|
-
- HY-N0584A
-
|
Anisodamine hydrobromide
6-Hydroxyhyoscyamine hydrobromide
|
mAChR
|
Inflammation/Immunology
|
|
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties.
|
-
- HY-N0627
-
-
- HY-N10448
-
-
- HY-139607
-
-
- HY-N0737
-
-
- HY-N1482
-
|
Methyl palmitate
|
Others
|
Inflammation/Immunology
|
|
Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects.
|
-
- HY-13609S
-
-
- HY-131259
-
-
- HY-N2381
-
|
Menthone
|
Parasite
|
Infection
Inflammation/Immunology
|
|
Menthone, a monoterpene extracted from plants and Mentha oil with strong antioxidant properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni Infection.
|
-
- HY-B1121S
-
-
- HY-N7560
-
|
Safranal
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.
|
-
- HY-16126
-
-
- HY-N3925
-
-
- HY-B1046S
-
|
Clofazimine-d7
|
Bacterial
Antibiotic
|
Inflammation/Immunology
|
|
Clofazimine-d7 is deuterium labeled Clofazimine. Clofazimine is an iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
|
-
- HY-76251S
-
-
- HY-N1451
-
-
- HY-N0773
-
|
Isovitexin
Saponaretin; Homovitexin
|
JNK
NF-κB
|
Inflammation/Immunology
|
|
Isovitexin is a flavonoid isolated from rice hulls of Oryza sativa, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.
|
-
- HY-N2195
-
|
Nootkatone
(+)-Nootkatone
|
Others
|
Neurological Disease
|
|
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease.
|
-
- HY-B0367S
-
-
- HY-N6644
-
|
Crocin III
|
Others
|
Cancer
Inflammation/Immunology
|
|
Crocin III is a crocetin from saffron (Crocus sutivus L.). Crocetins inhibit cell growth of tumor cells and has anti-inflammatory activity. Crocins serve as spices and coloring agents.
|
-
- HY-32735
-
|
Triptolide
PG490
|
NF-κB
Apoptosis
|
Cancer
|
|
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor.
|
-
- HY-N0194
-
-
- HY-N1205
-
|
Spathulenol
|
Others
|
Cancer
|
|
Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].
|
-
- HY-23119
-
-
- HY-131258
-
-
- HY-131260
-
-
- HY-13609S2
-
-
- HY-N2410
-
|
N-trans-Feruloyltyramine
N-feruloyltyramine; Moupinamide
|
COX
|
Inflammation/Immunology
|
|
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid from Piper nigru, is an inhibitor of COX1 and COX2, with potential antioxidant properties. N-trans-Feruloyltyramine possesses anti-inflammatory activity.
|
-
- HY-N2495
-
|
Isomucronulatol
|
Others
|
Inflammation/Immunology
|
|
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect.
|
-
- HY-101784
-
-
- HY-N1949
-
|
Homoplantaginin
|
TNF Receptor
NF-κB
|
Inflammation/Immunology
|
|
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
|
-
- HY-N10450
-
-
- HY-N10225
-
|
Thielavin A
|
Prostaglandin Receptor
|
Endocrinology
Cardiovascular Disease
|
|
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration.
|
-
- HY-32345
-
|
Elocalcitol
BXL-628; Ro-26-9228
|
VD/VDR
|
Cancer
Inflammation/Immunology
|
|
Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells.
|
-
- HY-N3115
-
|
Palbinone
|
Others
|
Inflammation/Immunology
|
|
Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits 3α-hydroxysteroid dehydrogenase (3α-HSD), with an IC50 of 46 nM. Anti-inflammatory activity.
|
-
- HY-N9488
-
-
- HY-N2593
-
|
Isorhapontigenin
|
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation.
|
-
- HY-N1422
-
|
Hecogenin
|
Fungal
|
Infection
Inflammation/Immunology
|
|
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.
|
-
- HY-122381
-
|
Kyotorphin
|
Bacterial
Endogenous Metabolite
|
Neurological Disease
|
|
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients.
|
-
- HY-121054
-
|
Chalcone
|
Bacterial
|
Cancer
Inflammation/Immunology
|
|
Chalcone is isolated from Glycyrrhizae inflata and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities.
|
-
- HY-14645
-
|
(-)-DHMEQ
Dehydroxymethylepoxyquinomicin
|
NF-κB
|
Cancer
Inflammation/Immunology
|
|
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity.
|
-
- HY-106907
-
-
- HY-17358
-
-
- HY-150608
-
-
- HY-B0890
-
|
Zomepirac sodium salt
McN-2783-21-98
|
PGE synthase
|
Inflammation/Immunology
|
|
Zomepirac sodium salt (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac sodium salt is a non-steroidal anti-inflammatory drug (NSAID). Zomepirac sodium salt can cause immune-mediated liver injury.
|
-
- HY-N0708S
-
-
- HY-N2050
-
-
- HY-B0270S
-
-
- HY-B0758
-
|
Troxipide
|
Others
|
Inflammation/Immunology
|
|
Troxipide is an orally active defensive factor-enhancing therapeutic agent for gastritis and gastric ulcer (GU). Troxipide is a non-antisecretory gastro protective agent with antiulcer, anti-inflammatory and mucus-secreting properties.
|
-
- HY-B0261A
-
-
- HY-108617
-
|
YM976
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses.
|
-
- HY-N6261
-
|
Epimagnolin B
|
Others
|
Inflammation/Immunology
|
|
Epimagnolin B is a bisepoxylignan isolated from Magnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic effects.
|
-
- HY-N2217
-
-
- HY-P1539A
-
-
- HY-N2460
-
|
Aloesin
Aloeresin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Aloesin (Aloeresin) is an active constituent of the herb aloe vera and displays anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin exerts its anticancer effect through the MAPK signaling pathway.
|
-
- HY-108570
-
|
AUDA
|
Epoxide Hydrolase
|
Inflammation/Immunology
|
|
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.
|
-
- HY-B0493S
-
-
- HY-W013075
-
|
Rutin trihydrate
Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate
|
Others
|
Neurological Disease
|
|
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .
|
-
- HY-N2490
-
-
- HY-B0253
-
|
Piroxicam
CP-16171
|
COX
|
Inflammation/Immunology
Cancer
|
|
Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.
|
-
- HY-B0712B
-
|
Ceftriaxone sodium salt
Disodium ceftriaxone
|
Bacterial
Antibiotic
|
Infection
|
|
Ceftriaxone sodium salt (Disodium ceftriaxone) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-144237
-
|
BRP-201
|
PGE synthase
|
Inflammation/Immunology
|
|
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the treatment of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
|
-
- HY-W067056
-
|
Methyl (E)-cinnamate
Methyl (E)-3-phenylpropenoate
|
Others
|
Inflammation/Immunology
|
|
Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry.
|
-
- HY-N2094
-
|
Genipin 1-β-D-gentiobioside
Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside
|
Others
|
Inflammation/Immunology
|
|
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
|
-
- HY-N5083
-
|
Saponarin
|
Others
|
Inflammation/Immunology
|
|
Saponarin is a natural flavonoid isolated from Gypsophila trichotoma, with antioxidant, anti-inflammatory and hepatoprotective activities. Saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.
|
-
- HY-N0055
-
|
Chlorogenic acid
3-O-Caffeoylquinic acid; Heriguard; NSC-407296
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Bacterial
Influenza Virus
Endogenous Metabolite
|
Cancer
Infection
Inflammation/Immunology
|
|
Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
|
-
- HY-N6612
-
-
- HY-N2905
-
|
Aurantiamide acetate
Asperglaucide
|
Cathepsin
|
Inflammation/Immunology
|
|
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.
|
-
- HY-N6826
-
|
Asatone
|
NF-κB
|
Inflammation/Immunology
|
|
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.
|
-
- HY-N0268
-
|
Irisflorentin
|
NO Synthase
|
Inflammation/Immunology
|
|
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Rhizoma Belamcandae. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity.
|
-
- HY-107574
-
-
- HY-101021
-
|
Ascochlorin
Ilicicolin D
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity.
|
-
- HY-N2005
-
-
- HY-N6894
-
|
Pseudocoptisine acetate
Isocoptisine acetate
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
|
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
|
-
- HY-B1078
-
-
- HY-N4288
-
-
- HY-10529
-
-
- HY-N0637
-
-
- HY-N0820
-
-
- HY-N6894A
-
|
Pseudocoptisine chloride
Isocoptisine chloride
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
|
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
|
-
- HY-147179
-
-
- HY-19995
-
|
GSK137647A
GSK 137647
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
|
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response.
|
-
- HY-N4226
-
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
|
Others
|
Inflammation/Immunology
Cancer
|
|
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.
|
-
- HY-N0408
-
|
Picroside II
|
NF-κB
Reactive Oxygen Species
Apoptosis
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities.
picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways.
Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
|
-
- HY-17461A
-
-
- HY-B0712A
-
|
Ceftriaxone sodium hydrate
Ceftriaxone disodium hemiheptahydrate
|
Bacterial
Antibiotic
|
Infection
|
|
Ceftriaxone sodium hydrate (Ceftriaxone disodium hemiheptahydrate) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-N4149
-
|
Quercetagetin
6-Hydroxyquercetin
|
Pim
|
Cancer
Inflammation/Immunology
|
|
Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM). Anti-inflammatory and anticancer properties.
|
-
- HY-N0929
-
|
Hexahydrocurcumin
|
COX
Reactive Oxygen Species
|
Cancer
|
|
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities.
|
-
- HY-B0580S
-
|
Ketorolac-d5
|
COX
|
Inflammation/Immunology
|
|
Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-B1355AS
-
|
Oxyphenbutazone-d9
|
COX
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Oxyphenbutazone-d9 is the deuterium labeled Oxyphenbutazone. Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
|
-
- HY-B0574
-
|
Mefenamic acid
|
COX
|
Inflammation/Immunology
|
|
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-126294
-
|
AZD4604
JAK1-IN-7
|
JAK
|
Inflammation/Immunology
|
|
AZD4604 (JAK1-IN-7) is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect.
|
-
- HY-N0770
-
|
Isoliensinine
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells.
|
-
- HY-14882A
-
-
- HY-N2169
-
|
Polygalasaponin V
|
Others
|
Inflammation/Immunology
|
|
Polygalasaponin V is a triterpenoid saponin isolated from the aerial parts of Polygala japonica. Polygala japonica has been a folk medicine herb used as expectorant, anti-inflammatory, antibacterial and antidepressant agents in the south of China.
|
-
- HY-W002484
-
|
3-Hydroxy-4-methoxyacetophenone
Acetoisovanillone; Isoacetovanillone
|
Others
|
Inflammation/Immunology
|
|
3-Hydroxy-4-methoxyacetophenone(Acetoisovanillone; Isoacetovanillone) is an active compound isolated from P. spinosa. Isoacetovanillone possesses anti-inflammatory activity and prevented injuries due to administration of acetic acid in the colon.
|
-
- HY-N0064
-
-
- HY-N0616
-
|
Trifolirhizin
|
Tyrosinase
|
Cancer
Inflammation/Immunology
|
|
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.
|
-
- HY-100009
-
|
Ufenamate
Flufenamic acid butyl ester; Butyl flufenamate
|
Others
|
Inflammation/Immunology
|
|
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory agent. Ufenamate can be used for the research of skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis.
|
-
- HY-147693
-
-
- HY-144238
-
|
mPGES-1-IN-1
|
Others
|
Inflammation/Immunology
|
|
MPGES-1 is considered as a promising therapeutic target of the next generation anti-inflammatory drugs in the treatment of inflammatory diseases. The < b > IC < sub > 50 < / sub > < / b > value of mPGES-1-IN-1 is 0.03 μ M。
|
-
- HY-N9359
-
|
Toddaculin
|
Apoptosis
|
|
|
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity.
|
-
- HY-116429
-
-
- HY-133588S
-
-
- HY-146198
-
-
- HY-B1276A
-
-
- HY-N2569
-
-
- HY-N4147
-
-
- HY-N7541
-
|
Antrodin A
|
Others
|
Inflammation/Immunology
|
|
Antrodin A is one of the main active ingredients in the solid-state fermented A. camphorate mycelium. Antrodin A protects the liver from alcohol damage by improving the antioxidant and anti-inflammatory capacity of the liver and maintaining the stability of the intestinal flora.
|
-
- HY-N0250
-
-
- HY-125445
-
|
PCTR1
|
Others
|
Inflammation/Immunology
|
|
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
|
-
- HY-A0203
-
|
Pentosan Polysulfate
|
HIV
|
Infection
Inflammation/Immunology
|
|
Pentosan Polysulfate is an orally bioavailable medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate also displays a potent and selective anti-HIV activity. Pentosan Polysulfatecan be used for the research of interstitial cystitis.
|
-
- HY-147119
-
-
- HY-N0141
-
|
Parthenolide
(-)-Parthenolide
|
NF-κB
Autophagy
Mitophagy
Apoptosis
|
Cancer
|
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
|
-
- HY-N7335
-
-
- HY-13570S
-
-
- HY-17571A
-
|
Oxytocin acetate
α-Hypophamine acetate; Oxytocic hormone acetate
|
Oxytocin Receptor
Endogenous Metabolite
|
Endocrinology
|
|
Oxytocin acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
|
-
- HY-106093
-
|
Eltenac
|
COX
|
Inflammation/Immunology
|
|
Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood.
|
-
- HY-13633
-
|
Exisulind
|
Aldose Reductase
|
Metabolic Disease
|
|
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.
|
-
- HY-N2357
-
-
- HY-B1892
-
-
- HY-N0290
-
|
Mangiferin
|
NF-κB
Keap1-Nrf2
Apoptosis
|
Cancer
|
|
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.
|
-
- HY-100382
-
|
FPTQ
|
mGluR
|
Others
|
|
FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.
|
-
- HY-P0256
-
-
- HY-13696
-
-
- HY-126562
-
-
- HY-N3005
-
|
Britannin
|
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities.
|
-
- HY-15556A
-
-
- HY-13571S
-
-
- HY-15556
-
-
- HY-128922
-
-
- HY-12136
-
-
- HY-145310
-
-
- HY-N2478
-
|
Taraxasteryl acetate
|
Others
|
Inflammation/Immunology
|
|
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment[1] .
|
-
- HY-N1508
-
|
Ecliptasaponin A
|
Others
|
Inflammation/Immunology
|
|
Ecliptasaponin A , a pentacyclic triterpenoid saponin, is one of major compounds separated from Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory.
|
-
- HY-B0154
-
-
- HY-118139
-
|
Desmethyl Celecoxib
|
COX
|
Inflammation/Immunology
|
|
Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.
|
-
- HY-105008
-
|
Secoisolariciresinol diglucoside
(S,S)-SDG; (S,S)-LGM2605
|
Others
|
Inflammation/Immunology
Neurological Disease
Cardiovascular Disease
|
|
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.
|
-
- HY-111149A
-
|
PS372424 hydrochloride
|
CXCR
|
Inflammation/Immunology
|
|
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.
|
-
- HY-N0802
-
|
Tenuigenin
Senegenin
|
NF-κB
Bacterial
|
Infection
Inflammation/Immunology
|
|
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.
|
-
- HY-N0474S
-
-
- HY-B1832S
-
-
- HY-N6258
-
|
Kahweol
|
AMPK
Apoptosis
|
Metabolic Disease
|
|
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
|
-
- HY-18234A
-
|
Leupeptin hemisulfate
|
Cathepsin
|
Inflammation/Immunology
|
|
Leupeptin hemisulfate is a membrane-permeable thiol protease inhibitor that inhibits Cathepsin B, Cathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion. Leupeptin hemisulfate also exhibits anti-inflammatory effect.
|
-
- HY-N0608
-
|
Myrislignan
|
NF-κB
|
Inflammation/Immunology
|
|
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.
|
-
- HY-Y0892
-
-
- HY-N5113
-
|
6α-Chloro-5β-hydroxywithaferin A
|
Others
|
Others
|
|
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties.
|
-
- HY-N4108
-
|
Hypophyllanthin
|
P-glycoprotein
|
Cancer
Inflammation/Immunology
|
|
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity.
|
-
- HY-N0220
-
|
Dauricine
|
NF-κB
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.
|
-
- HY-146046
-
|
Antitumor agent-56
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active.
|
-
- HY-111149
-
|
PS372424
|
CXCR
|
Inflammation/Immunology
|
|
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.
|
-
- HY-147809
-
|
COX-2-IN-20
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity.
|
-
- HY-13570S1
-
-
- HY-N0269
-
|
Echinatin
|
Others
|
Inflammation/Immunology
|
|
Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects. Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat.
|
-
- HY-N1404
-
|
Sodium aescinate
|
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.
|
-
- HY-133916
-
-
- HY-14658A
-
-
- HY-N2000
-
|
Bellidifolin
|
HIV
|
Cancer
Infection
Inflammation/Immunology
|
|
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.
|
-
- HY-13723A
-
|
Pimecrolimus hydrate
SDZ-ASM 981 hydrate
|
Phosphatase
|
Inflammation/Immunology
|
|
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus.
|
-
- HY-N7906
-
-
- HY-B0756
-
-
- HY-129098
-
|
DMHCA
|
LXR
|
Metabolic Disease
|
|
DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes.
|
-
- HY-147830
-
-
- HY-N4187
-
-
- HY-B1355AS1
-
-
- HY-19589
-
-
- HY-70072
-
|
D609
|
Phospholipase
|
Cancer
Infection
Inflammation/Immunology
|
|
D609, an antitumoural xanthate, is a specific and competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor with a Ki of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity.
|
-
- HY-118561
-
|
Bermoprofen
AD-1590
|
Others
|
Inflammation/Immunology
|
|
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits.
|
-
- HY-109011
-
|
Rosiptor
AQX-1125
|
Phosphatase
|
Cancer
|
|
Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
|
-
- HY-N0180S
-
-
- HY-N0427
-
|
Phellodendrine
|
Akt
NF-κB
|
Inflammation/Immunology
|
|
Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .
|
-
- HY-N0691
-
|
Schisandrin
Schizandrin; Schizandrol; Schizandrol-A
|
Autophagy
|
Inflammation/Immunology
Cancer
|
|
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats.
|
-
- HY-N7766
-
|
Rubropunctatin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity.
|
-
- HY-N8435
-
-
- HY-A0203A
-
|
Pentosan Polysulfate Sodium (W/W 43%)
|
HIV
|
Infection
Inflammation/Immunology
|
|
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.
|
-
- HY-N8092
-
-
- HY-122521
-
|
Sootepin D
|
NF-κB
|
Inflammation/Immunology
|
|
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC50 of 8.3μM. Sootepin D has anti-inflammatory activity.
|
-
- HY-146053
-
-
- HY-N3848
-
-
- HY-N2080
-
|
Songorine
|
GABA Receptor
|
Cancer
|
|
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC).
|
-
- HY-13693S
-
-
- HY-N1082
-
-
- HY-113772
-
|
Inflachromene
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders.
|
-
- HY-N1782
-
-
- HY-N1353
-
-
- HY-N10106
-
-
- HY-A0213
-
|
Tiludronate
Tiludronic acid
|
Proton Pump
|
Inflammation/Immunology
|
|
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-N1506
-
|
Ganodermanontriol
|
Others
|
Cancer
|
|
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity.
|
-
- HY-106050
-
|
Tilomisole
Wy 18251
|
Others
|
Cancer
Inflammation/Immunology
|
|
Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation.
|
-
- HY-N2010
-
-
- HY-145684
-
-
- HY-130285
-
-
- HY-121192
-
-
- HY-N0439
-
-
- HY-N0301
-
|
Thiocolchicoside
|
GABA Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.
|
-
- HY-N0120A
-
|
Polydatin
Piceid
|
Autophagy
Apoptosis
Mitophagy
|
Inflammation/Immunology
Cancer
|
|
Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
|
-
- HY-N0295
-
|
Protocatechualdehyde
Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV
|
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
|
|
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.
|
-
- HY-135303
-
|
GLPG1205
|
GPR84
|
Inflammation/Immunology
|
|
GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.
|
-
- HY-B0493S1
-
-
- HY-N7765
-
-
- HY-N0364
-
-
- HY-N4134
-
|
Ciwujianoside C3
|
NO Synthase
|
Inflammation/Immunology
|
|
Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory.
|
-
- HY-13568
-
|
Benoxaprofen
LRCL 3794
|
COX
|
Inflammation/Immunology
|
|
Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation.
|
-
- HY-13693
-
-
- HY-P1050
-
|
COG 133
|
nAChR
|
Inflammation/Immunology
Neurological Disease
|
|
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM.
|
-
- HY-147815
-
|
COX-2-IN-21
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential.
|
-
- HY-N2255
-
-
- HY-B1276
-
-
- HY-A0221
-
|
Ridogrel
R 68070
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities.
|
-
- HY-106139
-
|
Bimosiamose
TBC-1269
|
Others
|
Inflammation/Immunology
|
|
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.
|
-
- HY-N4097
-
|
Incensole
|
Others
|
Neurological Disease
|
|
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression.
|
-
- HY-N0836
-
|
Jervine
11-Ketocyclopamine
|
Hedgehog
Smo
|
Cancer
Inflammation/Immunology
|
|
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.
|
-
- HY-W040265
-
|
Fenamic acid
N-Phenylanthranilic acid
|
Chloride Channel
|
Inflammation/Immunology
|
|
Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent -.
|
-
- HY-N6961
-
|
Lapachol
|
Bacterial
Fungal
Influenza Virus
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
|
Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae). Lapachol shows anti-abscess, anti-ulcer, antileishmanial, anticarcinomic, antiedemic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, antibacterial, antifungal and pesticidal activities.
|
-
- HY-78131BS
-
|
(R)-(-)-Ibuprofen-d3
(R)-Ibuprofen-d3
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
(R)-(-)-Ibuprofen-d3 ((R)-Ibuprofen-d3) is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
|
-
- HY-120628
-
|
BMS-587101
|
Integrin
|
Inflammation/Immunology
|
|
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.
|
-
- HY-N0677
-
-
- HY-N0589
-
-
- HY-B0539
-
-
- HY-N1377
-
|
Nevadensin
|
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC50 of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive.
|
-
- HY-135408
-
-
- HY-A0213A
-
|
Tiludronate disodium
Tiludronic acid disodium
|
Proton Pump
|
Inflammation/Immunology
|
|
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-17609
-
|
Difelikefalin
CR-845; FE-202845
|
Opioid Receptor
|
Neurological Disease
|
|
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.
|
-
- HY-B0298A
-
-
- HY-13580
-
|
Budesonide
|
Glucocorticoid Receptor
|
Cancer
Inflammation/Immunology
|
|
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
|
-
- HY-B1227
-
-
- HY-N2191
-
|
Ecliptasaponin D
|
Others
|
Inflammation/Immunology
|
|
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba (L.) Hassk which is the aerial part of Eclipta prostrate. Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant and immunomodulatory[1,2].
|
-
- HY-N0003
-
|
Honokiol
NSC 293100
|
Akt
Autophagy
HCV
ERK
|
Cancer
|
|
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier.
|
-
- HY-N0188
-
|
Esculin
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway.
|
-
- HY-B0260S2
-
-
- HY-P0256A
-
-
- HY-N1023
-
-
- HY-108746
-
|
Defibrotide sodium
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research.
|
-
- HY-N7696
-
|
Physalin F
|
Apoptosis
|
Inflammation/Immunology
|
|
Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection.
|
-
- HY-B1616S
-
|
Clobetasone butyrate-d7
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Clobetasone butyrate-d7 is the deuterium labeled Clobetasone butyrate. Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.
|
-
- HY-B0212
-
|
Sulfapyridine
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities.
|
-
- HY-136177
-
-
- HY-B0260S3
-
-
- HY-N1429S2
-
|
Taurochenodeoxycholic acid-d4-1 sodium
12-Deoxycholyltaurine-d4-1 sodium
|
Apoptosis
Endogenous Metabolite
|
|
|
Taurochenodeoxycholic acid-d4-1 (sodium) is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
|
-
- HY-N2590
-
|
Lupenone
|
Parasite
|
Cancer
Infection
Inflammation/Immunology
|
|
Lupenone, isolated from Rhizoma Musae, belongs to lupane type triterpenoids. Lupenone shows various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity.
|
-
- HY-B0261S1
-
-
- HY-N7656
-
|
5,7,8-Trimethoxyflavone
Norwogonin 5,7,8-trimethyl ether
|
Others
|
Inflammation/Immunology
|
|
5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity.
|
-
- HY-14882
-
|
Cenicriviroc
TAK-652; TBR-652
|
CCR
HIV
|
Infection
Endocrinology
|
|
Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
|
-
- HY-B0260S4
-
|
Methylprednisolone-d2
U 7532-d2
|
Glucocorticoid Receptor
Autophagy
SARS-CoV
|
Others
|
|
Methylprednisolone-d2 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
|
-
- HY-B0336
-
|
Pranoprofen
|
COX
Apoptosis
PGE synthase
|
Cancer
Inflammation/Immunology
|
|
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
|
-
- HY-N6810
-
|
Thymol
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
|
-
- HY-N0608A
-
|
(Rac)-Myrislignan
|
NF-κB
|
Inflammation/Immunology
|
|
(Rac)-Myrislignan is the racemate of Myrislignan. Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.
|
-
- HY-14398S1
-
|
Celecoxib-d3
SC 58635-d3
|
COX
|
Inflammation/Immunology
Cancer
|
|
Celecoxib-d3 (SC 58635-d3) is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.
|
-
- HY-14398S
-
|
Celecoxib-d7
SC 58635-d7
|
COX
|
Inflammation/Immunology
Cancer
|
|
Celecoxib-d7 (SC 58635-d7) is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.
|
-
- HY-W015007
-
|
Metyrosine
|
COX
|
Cardiovascular Disease
|
|
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.
|
-
- HY-N8593
-
|
Undecane
|
TNF Receptor
|
Infection
|
|
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[
|
-
- HY-119447
-
|
Mavacoxib
|
COX
|
Inflammation/Immunology
|
|
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs.
|
-
- HY-17461
-
-
- HY-78131S1
-
|
Ibuprofen-13C,d3
(±)-Ibuprofen-13C,d3
|
COX
|
Inflammation/Immunology
Cancer
|
|
Ibuprofen-13C,d3 is the 13C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-N6884
-
-
- HY-N8471
-
|
Niazinin
|
Parasite
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC50 value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity.
|
-
- HY-32736
-
|
Triptonide
NSC 165677; PG 492
|
Wnt
β-catenin
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
|
-
- HY-N6007
-
-
- HY-N0677B
-
-
- HY-12122A
-
-
- HY-N0006S
-
|
Demethoxycurcumin-d7
Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7
|
Apoptosis
Autophagy
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Demethoxycurcumin-d7 (Curcumin II-d7) is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
|
-
- HY-A0158
-
|
Diflorasone
|
Others
|
Inflammation/Immunology
|
|
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis.
|
-
- HY-N8085
-
|
Icariside F2
|
NF-κB
|
Inflammation/Immunology
|
|
Icariside F2 is a potent NF-κB inhibitor with an IC50 value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity.
|
-
- HY-13571AS1
-
-
- HY-18978
-
|
GR79236
|
Adenosine Receptor
|
Inflammation/Immunology
|
|
GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a Kis of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions.
|
-
- HY-A0213B
-
|
Tiludronate disodium hemihydrate
Tiludronic acid disodium hemihydrate
|
Proton Pump
|
Metabolic Disease
|
|
Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H +-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-N0223
-
-
- HY-N2381S
-
|
Menthone-d3
|
Parasite
|
Infection
Inflammation/Immunology
|
|
Menthone-d3 is the deuterium labeled Menthone. Menthone, a monoterpene extracted from plants and Mentha oil with strong antioxidant properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni Infection.
|
-
- HY-B0261S
-
-
- HY-N0092
-
-
- HY-118827
-
|
Vedaprofen
Quadrisol; CERM 10202; PM 150
|
COX
|
Inflammation/Immunology
|
|
Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM.
|
-
- HY-119500
-
-
- HY-N0889
-
|
Ginkgetin
|
Wnt
Apoptosis
Autophagy
|
Inflammation/Immunology
Cancer
|
|
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ.
|
-
- HY-109083
-
|
Cilofexor
GS-9674
|
FXR
Autophagy
|
Inflammation/Immunology
|
|
Cilofexor (GS-9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. Cilofexor has anti-inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research.
|
-
- HY-B0580S1
-
|
Ketorolac D4
|
COX
|
Inflammation/Immunology
|
|
Ketorolac D4 (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
|
-
- HY-N0035
-
-
- HY-B0712S
-
|
Ceftriaxone-d3 disodium
|
Bacterial
Antibiotic
|
Infection
|
|
Ceftriaxone-d3 disodium is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-N10358
-
|
3-(2-Hydroxyethyl) thio withaferin A
|
NF-κB
|
Others
|
|
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
|
-
- HY-108966
-
|
Kushenol C
|
Beta-secretase
|
Inflammation/Immunology
|
|
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM.
|
-
- HY-N0036
-
|
Costunolide
(+)-Costunolide; Costus lactone
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.
|
-
- HY-114200
-
|
Imrecoxib
BAP-909
|
COX
|
Inflammation/Immunology
|
|
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect.
|
-
- HY-19929
-
|
Tanimilast
CHF-6001
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases.
|
-
- HY-146161
-
-
- HY-N2521
-
|
Tetramethylcurcumin
FLLL31
|
STAT
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects.
|
-
- HY-13571AS
-
-
- HY-15550
-
-
- HY-N0072
-
|
Brazilin
|
Apoptosis
Autophagy
|
Cancer
Inflammation/Immunology
|
|
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.
|
-
- HY-N1380S1
-
|
Guaiacol-d3
2-Methoxyphenol-d3
|
COX
NF-κB
|
Inflammation/Immunology
|
|
Guaiacol-d3 (2-Methoxyphenol-d3) is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.
|
-
- HY-W018800
-
-
- HY-10328
-
|
Neflamapimod
VX-745
|
p38 MAPK
Autophagy
|
Inflammation/Immunology
|
|
Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity.
|
-
- HY-132195
-
|
RORγt inverse agonist 14
|
ROR
|
Inflammation/Immunology
|
|
RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis.
|
-
- HY-B0298
-
|
Clemastine
HS-592; Meclastine
|
Histamine Receptor
|
Neurological Disease
|
|
Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects.
|
-
- HY-N7015
-
|
Zerumbone
|
HSV
|
Infection
|
|
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity.
|
-
- HY-B1799
-
|
Tolmetin
|
COX
|
Cancer
Inflammation/Immunology
|
|
Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 µM and 0.82 µM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID).
|
-
- HY-N4233
-
|
Bisabolangelone
|
p38 MAPK
|
Inflammation/Immunology
|
|
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities.
|
-
- HY-N0523
-
-
- HY-107935
-
|
6α-Fluoroprednisolone
Fluprednisolone
|
Others
|
Inflammation/Immunology
|
|
6α-Fluoroprednisolone (Fluprednisolone) is an internal standard for methylprednisolone, prednisolone and prednisone. 6α-Fluoroprednisolone is an anti-inflammatory agent. 6α-Fluoroprednisolone can be used for congenital adrenal virilism and Addison's disease research.
|
-
- HY-N0004
-
|
Oridonin
NSC-250682; Isodonol
|
Akt
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
|
-
- HY-N0523A
-
-
- HY-N1934
-
-
- HY-122219
-
|
R243
|
CCR
|
Inflammation/Immunology
|
|
R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects.
|
-
- HY-19212
-
|
S-2474
|
COX
Lipoxygenase
|
Inflammation/Immunology
|
|
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug.
|
-
- HY-15128
-
-
- HY-B0363
-
|
Nimesulide
R805
|
COX
|
Inflammation/Immunology
|
|
Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-14364
-
-
- HY-B1051S
-
|
Flumethasone-d3
Flumetasone-d3
|
Fungal
|
Inflammation/Immunology
|
|
Flumethasone-d3 (Flumetasone-d3) is the deuterium labeled Flumethasone. Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.
|
-
- HY-N0757
-
-
- HY-N2923
-
-
- HY-N0526
-
|
2"-O-Galloylhyperin
|
Others
|
Inflammation/Immunology
|
|
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage.
|
-
- HY-N0327
-
|
Lobetyolin
|
Apoptosis
Xanthine Oxidase
|
Metabolic Disease
|
|
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism.
|
-
- HY-N0829
-
|
Shionone
|
Others
|
Inflammation/Immunology
|
|
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities. Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure.
|
-
- HY-12403
-
|
Angiotensin (1-7)
Ang-(1-7)
|
Angiotensin Receptor
Angiotensin-converting Enzyme (ACE)
Endogenous Metabolite
|
Inflammation/Immunology
Cardiovascular Disease
Endocrinology
|
|
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
|
-
- HY-B0890S
-
|
Zomepirac-d4 sodium salt
|
PGE synthase
|
Inflammation/Immunology
|
|
Zomepirac-d4 sodium salt is the deuterium labeled Zomepirac sodium salt. Zomepirac sodium salt (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac sodium salt is a non-steroidal anti-inflammatory drug (NSAID). Zomepirac sodium salt can cause immune-mediated liver injury.
|
-
- HY-N0126
-
-
- HY-P0252
-
-
- HY-15321
-
|
Etoricoxib
MK-0663; L-791456
|
COX
|
Inflammation/Immunology
Cancer
|
|
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
|
-
- HY-18992
-
|
AS2444697
|
IRAK
|
Inflammation/Immunology
|
|
AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM. AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action.
|
-
- HY-P1050A
-
|
COG 133 TFA
|
nAChR
|
Inflammation/Immunology
Neurological Disease
|
|
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC50 of 445 nM.
|
-
- HY-76251S1
-
-
- HY-147195
-
-
- HY-N0506
-
|
Rosarin
|
Others
|
Neurological Disease
|
|
Rosarin is a cinnamyl alcohol glycoside isolated from Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .
|
-
- HY-122311
-
|
Orniplabin
SMTP-7
|
Reactive Oxygen Species
|
Inflammation/Immunology
Neurological Disease
|
|
Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS.
|
-
- HY-N8680
-
-
- HY-N6980
-
|
Licorice glycoside C2
|
Others
|
Cancer
Infection
|
|
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects.
|
-
- HY-109017
-
-
- HY-110398
-
|
5,6,7-Trimethoxyflavone
Baicalein trimethyl ether
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera.
|
-
- HY-N0720
-
|
Neobavaisoflavone
|
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
|
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation.
|
-
- HY-N6641
-
|
Monascin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor).
|
-
- HY-114950
-
|
EXP3179
Losartan Carboxaldehyde; DuP 167
|
COX
|
Inflammation/Immunology
Cardiovascular Disease
|
|
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions.
|
-
- HY-N6993
-
|
25-O-Methylalisol A
|
Others
|
Metabolic Disease
|
|
25-O-Methylalisol A is a protostane triterpenoids isolated from Alisma orientale. The dried rhizomes of the aquatic plant Alisma orientale known as Rhizoma Alismatis is a common traditional Chinese medicine used for diuretic, anti-inflammatory, and hypolipidemic purposes, as well as the treatment of diabetes.
|
-
- HY-N5091
-
-
- HY-B0559S
-
|
Nabumetone-d3
BRL14777-d3
|
COX
|
Inflammation/Immunology
Cancer
|
|
Nabumetone-d3 (BRL14777-d3) is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.
|
-
- HY-114335
-
|
Triphala
|
NF-κB
Fungal
|
Cancer
Infection
Inflammation/Immunology
|
|
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
|
-
- HY-B1453S1
-
|
(±)-Carnitine-d9 chloride
DL-Carnitine-d9 chloride
|
Reactive Oxygen Species
|
Metabolic Disease
|
|
(±)-Carnitine-d9 (DL-Carnitine-d9) chloride is the deuterium labeled (±)-Carnitine chloride. (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
|
-
- HY-N10458
-
|
Asperbisabolane L
|
|
Inflammation/Immunology
|
|
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the NF-κB-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells.
|
-
- HY-N0119
-
|
Naringin Dihydrochalcone
Naringin DC
|
NF-κB
|
Cancer
|
|
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
|
-
- HY-N2127
-
|
Pinostrobin
|
Ser/Thr Protease
|
Inflammation/Immunology
|
|
Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management.
|
-
- HY-14180
-
|
PHA 408
|
IKK
|
Inflammation/Immunology
|
|
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation.
|
-
- HY-17492S2
-
-
- HY-N0677A
-
|
Kalii Dehydrographolidi Succinas
Potassium dehydroandrographolide succinate
|
Others
|
Infection
Inflammation/Immunology
Cancer
|
|
Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
|
-
- HY-17358S
-
|
Loteprednol Etabonate D5
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Loteprednol Etabonate D5 is a deuterium labeled Loteprednol etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
|
-
- HY-N8213
-
-
- HY-N6020B
-
|
Butin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat.
|
-
- HY-100775
-
-
- HY-100775A
-
-
- HY-14289A
-
|
Cimetidine hydrochloride
SKF-92334 hydrochloride
|
Histamine Receptor
|
Cancer
Endocrinology
|
|
Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.
|
-
- HY-N1094
-
|
Verminoside
|
PARP
MDM-2/p53
|
Inflammation/Immunology
|
|
Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins.
|
-
- HY-112847A
-
|
Sulfosuccinimidyl oleate sodium
Sulfo-N-succinimidyl oleate sodium
|
Mitophagy
|
Inflammation/Immunology
|
|
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.
|
-
- HY-N1431A
-
|
Tabersonine hydrochloride
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Tabersonine hydrochloride is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and is a potential therapeutic candidate for the treatment of ALI/ARDS.
|
-
- HY-N9337
-
-
- HY-N7108
-
|
7-Hydroxyflavone
|
Others
|
Inflammation/Immunology
|
|
7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway.
|
-
- HY-B0230
-
|
Phenylbutazone
|
COX
|
Inflammation/Immunology
|
|
Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.
|
-
- HY-B0261S2
-
-
- HY-17492S1
-
-
- HY-N6624
-
|
Skullcapflavone II
|
Bacterial
|
Inflammation/Immunology
|
|
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.
|
-
- HY-14289
-
|
Cimetidine
SKF-92334
|
Histamine Receptor
|
Cancer
Endocrinology
|
|
Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity.
|
-
- HY-N0496
-
|
Ruscogenin
|
NOD-like Receptor (NLR)
|
Cardiovascular Disease
|
|
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities.
|
-
- HY-N6250
-
|
Isomucronulatol 7-O-glucoside
Isomucronulatol 7-O-β-glucoside
|
Others
|
Inflammation/Immunology
|
|
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect.
|
-
- HY-130994
-
|
Aeruginosin 865
|
NF-κB
ADC Cytotoxin
|
Cancer
Inflammation/Immunology
|
|
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect
|
-
- HY-B1489
-
-
- HY-106139A
-
|
Bimosiamose disodium
TBC-1269Z
|
Others
|
Inflammation/Immunology
|
|
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects.
|
-
- HY-N0158
-
|
Oxymatrine
|
TGF-beta/Smad
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
|
|
Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
|
-
- HY-131502
-
|
Taspine
|
P2X Receptor
|
Inflammation/Immunology
|
|
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage.
|
-
- HY-N10175
-
|
Berkeleyacetal C
|
Fungal
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways.
|
-
- HY-N3078
-
-
- HY-112847
-
|
Sulfosuccinimidyl oleate
Sulfo-N-succinimidyl oleate
|
Mitophagy
|
Inflammation/Immunology
|
|
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.
|
-
- HY-143444
-
|
JAK-IN-20
|
JAK
|
Inflammation/Immunology
|
|
JAK-IN-20 is a potent, pan and orally active JAK inhibitor with an IC50s of 7 nM, 5 nM, 14 nM for JAK1, JAK2, JAK3, respectively. JAK-IN-20 shows excellent pharmacokinetics and displays anti-inflammatory efficacy in vivo.
|
-
- HY-12412
-
|
ML132
NCGC-00183434
|
Caspase
|
Cancer
Inflammation/Immunology
|
|
ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of caspase 1. ML132 can be used for research in the field of anti-cancer and anti-inflammatory.
|
-
- HY-136592
-
-
- HY-129529
-
|
6-Hydroxyluteolin 7-glucoside
|
Others
|
Inflammation/Immunology
|
|
6-Hydroxyluteolin 7-glucoside is a flavonoid from Tanacetum parthenium and T. vulgare. 6-Hydroxyluteolin 7-glucoside inhibits the major pathways of arachidonate metabolism in leukocytes. 6-Hydroxyluteolin 7-glucoside has anti-inflammatory effect.
|
-
- HY-B0227
-
|
Ketoprofen
RP-19583
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
|
Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
|
-
- HY-128346
-
|
PQM130
|
Amyloid-β
|
Neurological Disease
|
|
PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development.
|
-
- HY-N2454
-
-
- HY-N1431
-
|
Tabersonine
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS.
|
-
- HY-N0711
-
-
- HY-N0579
-
|
Fraxin
Fraxoside
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Fraxin isolated from Acer tegmentosum, F. ornus or A. hippocastanum, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action, anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme.
|
-
- HY-121899
-
|
1-Oxo Ibuprofen
Ibuprofen EP impurity J
|
Others
|
Others
|
|
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-19672
-
|
Lirimilast
BAY 19-8004
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties.
|
-
- HY-10448S1
-
|
Capsaicin-d3
(E)-Capsaicin-d3
|
TRP Channel
Autophagy
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Capsaicin-d3 ((E)-Capsaicin-d3) is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.
|
-
- HY-78131A
-
|
(S)-(+)-Ibuprofen
(S)-Ibuprofen
|
COX
|
Inflammation/Immunology
|
|
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.
|
-
- HY-P0252A
-
-
- HY-N0328
-
-
- HY-N6642
-
|
Ankaflavin
|
PPAR
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
|
-
- HY-17358S1
-
-
- HY-N0448
-
|
10-Gingerol
|
Others
|
Cancer
Inflammation/Immunology
|
|
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM.
|
-
- HY-N2920
-
|
β-Amyrenonol
11-Oxo-β-amyrin
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
|
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.
|
-
- HY-B0253S
-
|
Piroxicam D3
CP-16171 D3
|
COX
|
Cancer
Inflammation/Immunology
|
|
Piroxicam D3 (CP-16171 D3) is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .
|
-
- HY-B0574S1
-
|
Mefenamic Acid-d3
|
COX
|
Inflammation/Immunology
|
|
Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-W041489
-
|
Chelidonic acid
|
NF-κB
Caspase
|
Inflammation/Immunology
Cancer
|
|
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM.
|
-
- HY-N1388
-
|
Tussilagone
|
Others
|
Inflammation/Immunology
|
|
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.
|
-
- HY-B0764
-
|
Bucladesine sodium
Dibutyryl cAMP sodium salt; DBcAMP sodium salt
|
PKA
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing.
|
-
- HY-N0570S1
-
-
- HY-N0570S
-
-
- HY-N0406
-
|
2"-O-beta-L-galactopyranosylorientin
|
Others
|
Inflammation/Immunology
|
|
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2). Anti-inflammatory effect.
|
-
- HY-N1231
-
|
Sophoraflavanone G
Kushenol F
|
Apoptosis
|
Cancer
|
|
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
|
-
- HY-N0393
-
|
Glabridin
|
PPAR
Reactive Oxygen Species
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Glabridin is a natural isoflavan from Glycyrrhiza glabra, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
|
-
- HY-B1245
-
|
Salsalate
Salicylsalicylic acid; Disalicylic acid
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Salsalate, a non-acetylated salicylate, is an effective antirheumatic drug that bypasses gastric absorption and also avoids cyclooxygenase inhibition. Salsalate has anti-inflammatory activity and reduces glucose levels, insulin resistance, and cytokine expression. Salsalate can be used in the research of type 2 diabetes.
|
-
- HY-N7072
-
-
- HY-N6857
-
|
Armepavine
|
NF-κB
|
Inflammation/Immunology
|
|
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades.
|
-
- HY-B0719
-
|
Ingenol Mebutate
Ingenol 3-angelate; PEP005
|
PKC
|
Cancer
Inflammation/Immunology
|
|
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
|
-
- HY-121955
-
-
- HY-B0260S1
-
-
- HY-N0613
-
|
Sauchinone
|
NF-κB
|
Inflammation/Immunology
|
|
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity.
|
-
- HY-N5086
-
-
- HY-16059
-
-
- HY-16726
-
|
Polmacoxib
CG100649
|
COX
Carbonic Anhydrase
|
Cancer
|
|
Polmacoxib (CG100649) is a first-in-class, orally active nonsteroidal anti-inflammatory drug (NSAID) which is a dual inhibitor of COX-2 (IC50 around 0.1 μg/ml) and carbonic anhydrase. Polmacoxib inhibits colorectal adenoma and tumor growth in mouse models.
|
-
- HY-147719
-
|
COX-2-IN-16
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity.
|
-
- HY-N7270
-
|
Apigenin-7-diglucuronide
|
Others
|
Inflammation/Immunology
|
|
Apigenin-7-diglucuronide is a flavonoid glycoside and is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation.
|
-
- HY-N1390
-
|
Syringaldehyde
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
|
Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
|
-
- HY-N6025
-
|
Clemastanin B
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
|
-
- HY-N1429S1
-
|
Taurochenodeoxycholic acid-d5 sodium
12-Deoxycholyltaurine-d5 sodium
|
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Taurochenodeoxycholic acid-d5 (12-Deoxycholyltaurine-d5) sodium is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
|
-
- HY-B0260S
-
-
- HY-119970
-
|
Helenalin
|
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding.
|
-
- HY-19304
-
|
Amelubant
BIIL 284
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity.
|
-
- HY-B0574S
-
|
Mefenamic acid D4
|
COX
|
Inflammation/Immunology
|
|
Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-N2027S
-
|
Taurochenodeoxycholic acid-d4 sodium
12-Deoxycholyltaurine-d4 sodium
|
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Taurochenodeoxycholic acid-d4 (12-Deoxycholyltaurine-d4) sodium is the deuterium labeled Taurochenodeoxycholic acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
|
-
- HY-147961
-
|
COX-2-IN-23
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.
|
-
- HY-N1196
-
|
Suberosin
|
NF-κB
|
Inflammation/Immunology
|
|
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB.
|
-
- HY-13858A
-
|
Sarecycline hydrochloride
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.
|
-
- HY-118139S
-
|
Celecoxib-d4
|
COX
|
Inflammation/Immunology
|
|
Celecoxib-d4 is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.
|
-
- HY-145846
-
|
iNOs-IN-1
|
NO Synthase
Interleukin Related
|
Inflammation/Immunology
|
|
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects.
|
-
- HY-N1677
-
|
2,6-Dimethoxy-1,4-benzoquinone
|
Bacterial
Parasite
|
Cancer
Infection
Metabolic Disease
Inflammation/Immunology
|
|
2,6-Dimethoxy-1,4-benzoquinone, a natural phytochemical, is a known haustorial inducing factor. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimalaria effects.
子
|
-
- HY-N1976
-
-
- HY-N0443
-
|
N-Methylcytisine
Caulophylline
|
nAChR
|
Inflammation/Immunology
|
|
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia.
|
-
- HY-32343S
-
-
- HY-118139S1
-
|
Desmethyl Celecoxib-d4
|
COX
|
Inflammation/Immunology
|
|
Desmethyl Celecoxib-d4 is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.
|
-
- HY-B0154S1
-
-
- HY-N3075
-
|
Phytol
(E)-Phytol
|
Parasite
Bacterial
|
Infection
|
|
Phytol ((E)-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, possesses promising antischistosomal properties. Phytol has antinociceptive and antioxidant activitiesas well as anti-inflammatory and antiallergic effects. Phytol has antimicrobial activity against Mycobacterium tuberculosis and Staphylococcus aureus.
|
-
- HY-N0120
-
|
(E/Z)-Polydatin
(E/Z)-Piceid
|
Others
|
Inflammation/Immunology
|
|
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions.
|
-
- HY-B0335
-
|
Tolfenamic Acid
GEA 6414
|
COX
|
Inflammation/Immunology
Cancer
|
|
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-17492S
-
-
- HY-B0539S3
-
-
- HY-N4285
-
-
- HY-P0266B
-
-
- HY-136427
-
|
KRM-III
|
Others
|
Inflammation/Immunology
|
|
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity.
|
-
- HY-N0577
-
|
Apiin
|
Others
|
Inflammation/Immunology
|
|
Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells.
|
-
- HY-B1227S
-
-
- HY-N0201
-
|
Atractylenolide I
|
Toll-like Receptor (TLR)
JAK
STAT
|
Cancer
|
|
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
|
-
- HY-18342S
-
|
Diflunisal-d3
MK-647-d3
|
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal-d3 (MK-647-d3) is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-135750
-
|
VAF347
|
Aryl Hydrocarbon Receptor
|
Inflammation/Immunology
|
|
VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14 +CD11b + monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.
|
-
- HY-B0227A
-
|
Ketoprofen (lysinate)
RP-19583 (lysinate)
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
|
Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
|
-
- HY-N0389
-
|
Columbin
|
COX
Parasite
|
Inflammation/Immunology
|
|
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM).
|
-
- HY-N7627
-
-
- HY-N1181S
-
|
Tamarixetin-d3
4'-O-Methyl Quercetin-d3
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Tamarixetin-d3 (4'-O-Methyl Quercetin-d3) is the deuterium labeled Tamarixetin. Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy.
|
-
- HY-145307
-
|
DATPT
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
DATPT is a 12WLVSKF17 peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis.
|
-
- HY-N2485
-
|
4'-Methoxyresveratrol
4'-O-Methylresveratrol
|
Others
|
Inflammation/Immunology
|
|
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
|
-
- HY-Z0548S1
-
-
- HY-143884
-
|
JAK2/TYK2-IN-1
|
JAK
|
Inflammation/Immunology
|
|
JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. JAK2/TYK2-IN-2 has anti-inflammatory activity.
|
-
- HY-N0345
-
|
Liriope muscari baily saponins C
|
Others
|
Cancer
Inflammation/Immunology
|
|
Liriope muscari baily saponins C is one of major active compounds of L. muscari (Decne.) Baily. Liriope muscari baily saponins C possesses strong anti-inflammatory, immunopharmacological and cardioprotective activities. Liriope muscari baily saponins C has been studied as a candidate drug for cancer metastasis.
|
-
- HY-108741
-
|
Plecanatide
|
Guanylate Cyclase
|
Inflammation/Immunology
|
|
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.
|
-
