Search Result
Results for "
antimicrobial+agent
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
18
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-Y1326
-
-
-
- HY-B2232
-
|
Alkyldimethylbenzylammonium chloride
|
Bacterial
Biochemical Assay Reagents
|
Infection
|
|
Benzalkonium (Alkyldimethylbenzylammonium) chloride (51% in water) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (51% in water) is toxic .
|
-
-
- HY-12638
-
|
DDM
|
Environmental Pollutants
Fungal
Parasite
Bacterial
|
Infection
|
|
Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
-
- HY-B1267
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .
|
-
-
- HY-108365
-
|
ML-1709460
|
Bacterial
Antibiotic
|
Infection
|
|
Gamithromycin is an antimicrobial agent which can inhibit the growth of MmmSC strains B237 and Tan8 with MICs of 0.00012 and 0.00006 μg/mL, respectively.
|
-
-
- HY-B1444
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
|
-
-
- HY-103643
-
|
(-)-Fumagillol
|
Bacterial
|
Infection
|
|
Fumagillol is a direct precursor of fumagillin. Fumagillin, as an antimicrobial agent, is a potent and selective inhibitor of angiogenesis .
|
-
-
- HY-P3494
-
|
|
Hepcidin
Bacterial
|
Infection
Inflammation/Immunology
|
|
Hepcidin-25 (human) is an iron metabolism regulator and Antimicrobial agent. Hepcidin-25 (human) exerts anti-inflammatory and antimicrobial activities by regulating iron-mediated oxidative damage .
|
-
-
- HY-70083
-
-
-
- HY-108880
-
|
Carbenicillin indanyl sodium; CP-15464-2
|
Bacterial
|
Infection
|
|
Carindacillin (Carbenicillin indanyl) sodium is an orally active and broad-spectrum antimicrobial agent. Carindacillin sodium can be hydrolyzed to Carbenicillin in vivo. Carindacillin sodium can be used for the research of urinary-tract infection .
|
-
-
- HY-131102
-
|
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .
|
-
-
- HY-148431
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .
|
-
-
- HY-14762
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Besifloxacin is a fluoroquinolone antimicrobial agent. Besifloxacin can inhibit cytokine production by monocytes. Besifloxacin has broad-spectrum antibacterial activity .
|
-
-
- HY-136081A
-
|
|
Insecticide
|
Infection
|
|
Hexamidine diisethionate is an antimicrobial agent targeting Acanthamoeba protozoa. Hexamidine diisethionate is promising for research of ocular infectious diseases such as Acanthamoeba keratitis .
|
-
-
- HY-151402
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-8 (Compound 15) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-8 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.
|
-
-
- HY-121272
-
-
-
- HY-B0050
-
|
|
Bacterial
|
Infection
|
|
Delmopinol is an antimicrobial agent that can be used in the oral cavity to inhibit the formation of dental biofilm.
|
-
-
- HY-B1782
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .
|
-
-
- HY-B1267S1
-
|
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Sulfaguanidine- 13C6 is the 13C6 labeled Sulfaguanidine. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.
|
-
-
- HY-176970
-
|
|
Fungal
Bacterial
|
Infection
|
|
Antimicrobial agent-45 (Compound 16) is a broad-spectrum antibacterial agent. Antimicrobial agent-45 exhibits MICs against Cr. neoformans, S. aureus, MRSA and My. intracellulare of 9.25, 74.04, 74.04 and 74.04 μM respectively. Antimicrobial agent-45 can be used for the study of cryptococcal infections .
|
-
-
- HY-176969
-
-
-
- HY-P11239
-
-
-
- HY-101651
-
-
-
- HY-123652
-
|
|
Parasite
|
Infection
|
|
Etofamide is an antimicrobial agent with IC50 value of 5.96 mg/L against amoeba .
|
-
-
- HY-B0050A
-
|
|
Bacterial
|
Infection
|
|
Delmopinol hydrochloride is an antimicrobial agent that can be used in the oral cavity to inhibit the formation of dental biofilm .
|
-
-
- HY-147944
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent. Antimicrobial agent-4 exhibits considerable activity against the microbial pathogens. Antimicrobial agent-4 delivers reliable toxicity to kill the bacteria and fungi. Antimicrobial agent-4 shows high binding energy value of −10.0 kcal/mole against the target enzyme .
|
-
-
- HY-W452285
-
-
-
- HY-131048
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-33 (Compound 2b) is an antimicrobial agent, with MIC values of 2-64 μg/mL. Antimicrobial agent-33 is an active compound against Staph. Aureus .
|
-
-
- HY-155364
-
-
-
- HY-158425
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-31 (compound 4a) is a potent antimicrobial agent. Antimicrobial agent-31 inhibits Salmonella enterica serovar Typhimurium and E.coli with MIC values of 19.24, 11.31 µg/mL, respectively .
|
-
-
- HY-151403
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity .
|
-
-
- HY-151400
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity .
|
-
-
- HY-N3947
-
|
|
Bacterial
|
Infection
|
|
Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent .
|
-
-
- HY-131051
-
|
|
Reactive Oxygen Species (ROS)
Bacterial
Fungal
|
Infection
|
|
Antimicrobial agent-41 (Compound 19) is a thiazolidinedione derivative. Antimicrobial agent-41 exhibits excellent antioxidant activity (IC50 = 27.66 μg/mL). Antimicrobial agent-41 also exhibits antidiabetic activity (IC50 = 40.01 μg/mL). Antimicrobial agent-41 has antimicrobial activity again both bacterial and fungi .
|
-
-
- HY-147876
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antimicrobial agent-3 (Compound U10) is an antimicrobial agent against bacterial, fungal and tubercular infections .
|
-
-
- HY-146460
-
|
|
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antimicrobial agent-2 (compound V-a) is a broad-spectrum antimicrobial agent, possessing inhibitory activity against various Gram-positive and -negative bacteria. Antimicrobial agent-2 has excellent inhibitory effect on Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 1 μg/mL. Antimicrobial agent-2 can effectively damage the membrane and lead to the leakage of protein, also can induce the generation of ROS. Antimicrobial agent-2 exhibits low toxicity, no obvious resistance and good bioavailability .
|
-
-
- HY-170609
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-36 (Compound 8b) is an antimicrobial agent that significantly inhibits the level of DNA gyrase, with an IC50 value of 4.56 µM. Antimicrobial agent-36 can also be used for the preparation of nanopharmaceutical formulations, for the research and development of novel antibiotics .
|
-
-
- HY-135196
-
|
MDL 62873
|
Bacterial
Drug Derivative
|
Infection
|
|
Mideplanin (MDL 62873) is an antimicrobial agent, semisynthetic amide derivative of Teicoplanin (HY-A0097). Mideplanin is highly active in vitro against staphylococci .
|
-
-
- HY-151401
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation .
|
-
-
- HY-Q50147
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-21 (Compound IIm) is a bacterial inhibitor. Antimicrobial agent-21 is active against gram-positive and gram-negative bacterial .
|
-
-
- HY-N9947
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Methyl-6-gingerol is an antimicrobial agent derived from Aframomum melegueta that exhibits anti-mycobacterial activity by inhibiting the efflux of toxins within Mycobacterium species .
|
-
-
- HY-168852
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-37 (compound 6a) is a potent broad-spectrum antimicrobial agent that has a biofilm-destroying effect, acting on bacterial membranes and cracking them .
|
-
-
- HY-Y1326R
-
|
|
Biochemical Assay Reagents
Reference Standards
Bacterial
|
Infection
|
|
Sodium metabisulfite (Standard) is the analytical standard of Sodium metabisulfite. This product is intended for research and analytical applications.Sodium metabisulfite, a sulfite salt, is used as an antioxidant and antimicrobial agent in a variety of drugs and functions as a preservative in many food preparations.
|
-
-
- HY-151399
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation .
|
-
-
- HY-136613
-
|
|
Bacterial
|
Infection
|
|
Demethyl linezolid is a impurity of linezolid. Demethyl linezolid is a useful antimicrobial agent extracted from patent WO1995007271A1, example 9, effective against a number of human and veterinary pathogens .
|
-
-
- HY-131049
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-30 (Compound T10) is an antimicrobial agent, with MIC values of 18.7-21.0 µg/mL for S. aureus, S. epidermidis, E. coli, P. aeruginosa, A. niger, and A. fumigatus .
|
-
-
- HY-161432
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-29 (Compound C35) affects the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore. Antimicrobial agent-29 helps the discovery of IsdB:Hb PPI inhibitors .
|
-
-
- HY-146078
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines .
|
-
-
- HY-155546
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
|
-
-
- HY-155769
-
|
|
Fungal
|
Infection
|
|
Antimicrobial agent-24 (compound E8) is a hydrazide compound with excellent and broad-spectrum fungicidal activities. Antimicrobial agent-24 affects the normal function of the plasma membrane, further generating changes in the morphology and subcellular structure of mycelia .
|
-
- HY-161988
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Antimicrobial agent-34 (compound 4h) is an antibacterial agent (MIC = 1–4 μg/mL), with a clogP value of 9.14. Antimicrobial agent-34 has good plasma stability (HC50 of 131.1 μg/mL) and good membrane selectivity (HC50/MIC is 65.6), with rapid sterilization capability. Antimicrobial agent-34 destroys the integrity of bacterial cell membranes, induces an increase in intracellular reactive oxygen species, and leaks protein and DNA, ultimately leading to bacterial death. Antimicrobial agent-34 demonstrates significant in vivo antibacterial potency in a mouse sepsis model infected with Staphylococcus aureus ATCC43300 .
|
-
- HY-163615
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-32 (Compound 4g) is an antimicrobial agent that exhibits significant activity against various bacteria, including Staphylococcus aureus, Bacillus subtilis, Bacillus cereus (MIC=1000 µg/mL), Klebsiella pneumonia, and Staphylococcus aureus (MRSA) (MIC=500 µg/mL), as well as Escherichia coli (MIC=250 µg/mL). Additionally, Antimicrobial agent-32 inhibits the proliferation of MCF-7, HCT-116, and HepG-2 cells, demonstrating anticancer activity .
|
-
- HY-151501
-
-
- HY-170367
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-35 (Compound c9) exhibits antibacterial agent, that inhibits S. aureus, E. coli, E. faecalis, and S. maltophilia with MIC of 0.5-2 μg/mL. Antimicrobial agent-35 exhibits cytotoxicity against HT-22 with IC50 of 130.4 μg/mL .
|
-
- HY-151497
-
-
- HY-151502
-
-
- HY-169571
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-38 (compound 10) is a potent inhibitor of methicillin-resistant S. aureus strain ATCC 700699 and nonresistant strain ATCC 29213, with MICs of 32 and 64 mg/L .
|
-
- HY-N12460
-
-
- HY-131718
-
|
|
Bacterial
|
Infection
|
|
(1-Isothiocyanatoethyl)benzene (compound 27) is an antimicrobial agent .
|
-
- HY-164003
-
|
|
Bacterial
|
Infection
|
|
Dapabutan is an antimicrobial agent with activity against Gram-positive bacteria .
|
-
- HY-76611
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-48 (P119 103) is an antimicrobial agent. Antimicrobial agent-48 binds to paНО. Antimicrobial agent-48 exhibits a MIC50 of >250 μg/mL. Antimicrobial agent-48 can be used in research on Escherichia coli infections .
|
-
- HY-13451A
-
|
|
Bacterial
|
Infection
|
|
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments.
|
-
- HY-156975
-
|
|
Bacterial
|
Infection
|
|
Sulfatrozole is a sulfanilamide derivative. Sulfatrozole is an antimicrobial agent with broad-spectrum activity .
|
-
- HY-N7747
-
|
|
Others
|
Infection
|
|
Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent .
|
-
- HY-W013429
-
|
|
Bacterial
|
Infection
|
|
4-Glycidyloxycarbazole (compound 8) is an antimicrobial agent that disrupts bacterial biofilm formation .
|
-
- HY-169745
-
-
- HY-121272AS
-
-
- HY-107996
-
|
Emcol E 607
|
Bacterial
|
Infection
|
|
Lapyrium chloride (Emcol E 607) is a broad-spectrum antimicrobial agent that can be used as an antiseptic and disinfectant .
|
-
- HY-100306
-
|
|
Bacterial
|
Infection
|
|
PNU-176798 is an antimicrobial agent, targeting protein synthesis in a wide spectrum of gram-positive and anaerobic bacteria.
|
-
- HY-125676
-
|
|
Drug Derivative
Bacterial
|
Others
|
|
Thermopterin is a derivative of the antimicrobial agent Pterin (HY-W037825) isolated from Methanoculleus thermophilus .
|
-
- HY-121272R
-
-
- HY-137168
-
|
|
Bacterial
|
Infection
|
|
LAB 149202F is an acylanilide antimicrobial agent that also has inhibitory effects on strains that produce formyl and phosphate resistance .
|
-
- HY-119929
-
|
|
Bacterial
|
Infection
|
|
B 669, a c10fazimine analogue, is an antimicrobial agent. B 669 has the activity against Mycobacterium ieprae .
|
-
- HY-175699
-
|
|
Fungal
|
Infection
|
|
Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candida albicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach .
|
-
- HY-163716
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 222 ((R)-O30 (5)) is a antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-161148
-
|
|
Bacterial
|
Infection
|
|
FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)[1].
|
-
- HY-B0343R
-
|
A-56620 (Standard)
|
Reference Standards
Antibiotic
Bacterial
|
Infection
|
|
Sarafloxacin (Standard) is the analytical standard of Sarafloxacin. This product is intended for research and analytical applications. Sarafloxacin (A-56620) is a fluoroquinolone antimicrobial agent .
|
-
- HY-122073
-
|
|
Bacterial
|
Infection
|
|
Furalazine is an antimicrobial agent. Furalazine shows activity against drug-resistant strains of cholera bacteria. Furalazine has the potential for the research of cholera .
|
-
- HY-180330
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-46 is a inhibitor of Salmonella typhimurium serine acetyltransferase (StSAT) with an IC50 of 48.6 μM. Antimicrobial agent-46 inhibits bacterial growth in minimal medium lacking cysteine (LB 20%). Antimicrobial agent-46 exerts its effect by targeting the cysteine biosynthesis pathway, which is crucial for bacterial persistence and adaptability. Antimicrobial agent-46 exhibits antibacterial activity against the Gram-negative bacterium Escherichia coli. Antimicrobial agent-46 can be used in infection-related research .
|
-
- HY-B0343S
-
|
A-56620-d8
|
Isotope-Labeled Compounds
|
Infection
|
|
Sarafloxacin-d8 is the deuterium labeled Sarafloxacin(HY-B0343).Sarafloxacin (A-56620) is a fluoroquinolone antimicrobial agent .
|
-
- HY-170847
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 24 (compound 6K) is an antimicrobial agent that targets Staphylococcus aureus (MRSA), especially penicillin-resistant Staphylococcus aureus .
|
-
- HY-181512
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-47 is an anti-mycobacterial agent. Antimicrobial agent-47 exhibits inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC50 of 0.78 μg/mL. Antimicrobial agent-47 can be used in the research of tuberculosis .
|
-
- HY-12638R
-
|
DDM (Standard)
|
Reference Standards
Bacterial
Fungal
Parasite
|
Infection
|
|
Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-183705
-
|
|
Fungal
Mitochondrial Metabolism
ATP Synthase
|
Infection
|
|
Antimicrobial agent-50 (Compound C2) is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC50 of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively .
|
-
- HY-144252
-
|
|
ROS Kinase
|
Infection
|
|
Antimicrobial agent 69 is a novel structural antimicrobial regulator and has been used to fight deadly multidrug-resistant bacterial infections, and its MICs value is 2.978 μM.
|
-
- HY-123219
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Salifluor is a broad spectrum antimicrobial agent that has been investigated for its abilities to inhibit dental plaque formation. Salifluor can act as an effective anti-inflammatory agent .
|
-
- HY-N3602
-
|
(-)-Rengyolone
|
Bacterial
|
Inflammation/Immunology
|
|
Cleroindicin F ((-)-Rengyolone), a cleroindicin, is an antimicrobial agent. Cleroindicin F shows relatively high anticandidal activity against Candida strains with a MIC value down to 12.5 µg/mL .
|
-
- HY-B1782R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sulfamoxole (Standard) is the analytical standard of Sulfamoxole. This product is intended for research and analytical applications. Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .
|
-
- HY-175313
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 286 (compound 5) is an effective broad-spectrum antimicrobial agent with strong inhibitory activity against methicillin-resistant S. aureus (MRSA) with an MIC of 25 μg/mL .
|
-
- HY-170993
-
|
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets 50S ribosomal subunit and inhibits bacterial protein synthesis. Antimicrobial agent-39 disrupts bacterial cell membranes, leads to leakage of cell contents, thereby exhibiting board-spectrum actibacterial activity. Antimicrobial agent-39 targets organic cation transporters (OCTs), accumulates in infected kidneys, thereby ameliorating pyelonephritis in mouse models .
|
-
- HY-173528
-
|
|
Bacterial
Fungal
|
Infection
Cancer
|
|
Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity .
|
-
- HY-B2232A
-
|
Alkyldimethylbenzylammonium chloride (solid)
|
Biochemical Assay Reagents
Bacterial
|
Infection
|
|
Benzalkonium chloride (solid) (Alkyldimethylbenzylammonium chloride (solid)) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (solid) is toxic .
|
-
- HY-133936
-
|
|
Bacterial
|
Others
|
|
Sulfaethidole, a heterocyclic sulfonamide, is an antimicrobial agent. Sulfaethidole binds to bovine Serum Albumin (BSA) with a pKA of 6.0 .
|
-
- HY-W028039
-
-
- HY-W587449
-
|
|
Drug Intermediate
|
Others
|
|
Chlorhexidine impurity 1 is a impurity of Chlorhexidine (HY-B1248). Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes.
|
-
- HY-183176
-
|
|
Bacterial
Fungal
|
Infection
|
|
Laurolinium acetate is a cationic antimicrobial agent. Laurolinium acetate exerts activity against Gram-positive and Gram-negative bacteria, and fungi. Laurolinium acetate can be used for the research of microbial infection .
|
-
- HY-W792760
-
|
|
Bacterial
|
Infection
|
|
(E)-2-(4-Cinnamoylphenoxy)acetic acid is an antimicrobial agent with a minimum inhibitory concentration of 125 μg/mL against Mycobacterium smegmatis, Staphylococcus aureus, and Candida albicans .
|
-
- HY-N19815
-
|
Aspergilol E
|
Bacterial
Fungal
|
Infection
|
|
Gibellulin A is a natural antimicrobial agent. Gibellulin A inhibits the growth of aquatic bacteria, human pathogenic bacteria and phytopathogenic fungi.Gibellulin A can be used for the research of bacterial and fungal infections .
|
-
- HY-N16692
-
|
|
Bacterial
|
Infection
|
|
Shizukolidol is an antimicrobial agent that can be isolated from polyfollicles of Magnolia vovidessi. Shizukolidol shows antibacterial activity against Chryseobacterium sp. Shizukolidol can be used for the research of bacterial infection .
|
-
- HY-N19688
-
|
|
Bacterial
|
Infection
|
|
Glucomoringin, a structurally unusual glucosinolate found in seeds of Moringa oleifera Lam., is an antimicrobial agent. Glucomoringin permits to maximize it's power when bioactivated with myrosinase. Glucomoringin can be used for the research of bacterial infections .
|
-
- HY-131102R
-
|
|
Reference Standards
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Mequindox (Standard) is the analytical standard of Mequindox. This product is intended for research and analytical applications. Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .
|
-
- HY-I0678R
-
|
|
Reference Standards
Drug Metabolite
PDGFR
|
Cancer
|
Quinocetone (Standard) is the analytical standard of Quinocetone. This product is intended for research and analytical applications. Quinocetone is a potent synthetic antimicrobial agent that is used for improving the feed efficiency and controlling dysentery in food-producing animals .
|
-
- HY-B1729
-
-
- HY-A0090
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
- HY-N12752
-
|
Casbene
|
Bacterial
Fungal
|
Infection
|
|
(-)-Casbene (Casbene) is an antimicrobial agent that can be found in Euphorbiaceae plants. (-)-Casbene retards Aspergillus niger development, and inhibits Escherichia coli growth. (-)-Casbene can be used for the research of bacterial and fungal infection .
|
-
- HY-N0172S
-
|
3,4-Dihydroxycinnamic acid-13C3
|
Bacterial
Fungal
|
Infection
|
|
Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .
|
-
- HY-U00291
-
|
|
Antibiotic
|
Infection
|
|
Tauroxicum can be used as a nontoxic, non-antimicrobial agent that can replace or supplement the use of antibiotics in the animal husbandry of livestock animals to increase health and general well-being, productivity, feed efficiency and weight gain.
|
-
- HY-135842
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes .
|
-
- HY-174389
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 283 (Compound 13) is an antimicrobial agent. Antibacterial agent 283 is active against both Gram-positive and Gram-negative bacteria, with potency comparable to the antibiotic Ampicillin (HY-B0522) .
|
-
- HY-W744147
-
|
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
4-Glycidyloxycarbazole-d5 is the deuterium labeled 4-Glycidyloxycarbazole (HY-W013429). 4-Glycidyloxycarbazole (compound 8) is an antimicrobial agent that disrupts bacterial biofilm formation .
|
-
- HY-10392
-
|
PNU-100480; U-100480; PF-02341272
|
Bacterial
Antibiotic
|
Infection
|
|
Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
|
-
- HY-175338
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 34 (Compound 6) is an antimicrobial agent targeting methicillin-resistant Staphylococcus aureus (MRSA) (MIC=14 μg/mL). Anti-MRSA agent 34 is promising for research of microbial infection .
|
-
- HY-P4836
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-14603R
-
|
Iodochlorohydroxyquinoline (Standard)
|
Reference Standards
Fungal
Autophagy
Mitophagy
Antibiotic
Parasite
|
Infection
Cancer
|
|
Clioquinol (Standard) is the analytical standard of Clioquinol. This product is intended for research and analytical applications. Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic .
|
-
- HY-B0614
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Mafenide is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis .
|
-
- HY-P3494B
-
|
|
Hepcidin
Bacterial
|
Infection
Inflammation/Immunology
|
|
Hepcidin-25 (human) TFA is an iron metabolism modulator and Antimicrobial agent. Hepcidin-25 (human) TFA shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury .
|
-
- HY-B1267R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sulfaguanidine (Standard) is the analytical standard of Sulfaguanidine. This product is intended for research and analytical applications. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .
|
-
- HY-N9987
-
-
- HY-B0614B
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide hydrochloride shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis .
|
-
- HY-W023253
-
|
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Biclotymol is an antimicrobial agent against gram-positive cocci. Biclotymol inhibits Streptococcus pneumoniae and Haemophilus influenzae, with MIC of 150 and 150 μM. Biclotymol exhibits anti-inflammatory and analgesic activity and ameliorates the otolaryngology infection and throat sore .
|
-
- HY-P3417
-
|
|
Bacterial
|
Infection
|
|
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .
|
-
- HY-159883
-
|
|
TrxR
|
Infection
|
|
DDHF20 is an antimicrobial agent against Staphylococcus aureus, targeting and inhibiting its thioredoxin reductase (TrxR). It acts as a competitive inhibitor for the NADPH binding site. DDHF20 is expected to be used in research related to antimicrobial infections caused by Staphylococcus aureus .
|
-
- HY-B0126
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-108365R
-
|
ML-1709460 (Standard)
|
Bacterial
Antibiotic
Reference Standards
|
Infection
|
|
Gamithromycin (Standard) is the analytical standard of Gamithromycin. This product is intended for research and analytical applications. Gamithromycin is an antimicrobial agent which can inhibit the growth of MmmSC strains B237 and Tan8 with MICs of 0.00012 and 0.00006 μg/mL, respectively.
|
-
- HY-168281
-
|
|
Bacterial
|
Infection
|
|
P6P-10,10 is an antimicrobial agent. P6P-10,10 has an IC50 value of 3 μM against colistin-resistant Acinetobacter baumannii .
|
-
- HY-B0126A
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-131925
-
|
DEA NONOate diethylamine
|
Bacterial
|
Infection
|
|
Diethylamine NONOate (DEA NONOate, diethylammonium salt) is a nitric oxide donor. Diethylamine NONOate is a potent antimicrobial agent, which can inhibit Escherichia coli growth. Diethylamine NONOate also can enhance preservation of the donor rat heart .
|
-
- HY-145417
-
|
|
Bacterial
|
Infection
|
|
G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter. Transmembrane ATP-binding cassette (ABC) transporters are crucial cellular machines that move molecules small and large across membranes. G092 has the potential for the research of antimicrobial agents .
|
-
- HY-162087
-
|
|
Bacterial
|
Infection
|
|
FabH-IN-2 (25), an antimicrobial agent, exhibits remarkable potential as an agent with an MIC range of 1.25-3.13 μg/mL against the tested bacterial strains and an IC50 of 2.0 μM against E. coli-derived FabH .
|
-
- HY-126462
-
|
|
Bacterial
|
Infection
|
|
Lantic acid is a triterpenoid compound possessing antimicrobial activity. Lantic acid exhibits inhibitory effects on a broad range of both Gram-positive and Gram-negative bacteria, with particular potency against Escherichia coli and Bacillus subtilis. Lantic acid is utilized in the research and development of antimicrobial agents .
|
-
- HY-15781
-
|
|
Bacterial
|
Infection
|
|
Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria .
|
-
- HY-126732
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
L-640876 is a broad-spectrum and orally active lactam antimicrobial agent. L-640876 showa MIC90 of 0.125 pg/mL for the E. coli strains, 2 /mg/mL for the S.choleraerai strains and 4 pg/mL for the S. typhinwrium strains .
|
-
- HY-W099582
-
-
- HY-130079
-
|
Penicillin G procaine
|
Bacterial
|
Infection
|
|
Procaine benzylpenicillin (Penicillin G procaine) is an antimicrobial agent. Procaine benzylpenicillin shows inhibitory activity against gram-positive bacteria and synergistic activity with Neomycin (HY-B0470). Procaine benzylpenicillin can be used in the study of bovine mastitis in animal husbandry .
|
-
- HY-W089856
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
Neurological Disease
|
|
Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries .
|
-
- HY-128384
-
|
|
Bacterial
|
Infection
|
|
Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration.
|
-
- HY-40040
-
|
|
Drug Intermediate
|
Infection
|
|
(S)-1-Boc-3-methylpiperazine is a synthetic intermediate for indole-piperazine hybrid antimicrobial agent preparation. (S)-1-Boc-3-methylpiperazine can be used for research on bacterial infection and fungal infection .
|
-
- HY-15781A
-
|
|
Bacterial
|
Infection
|
|
(R)-Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. (R)-Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria .
|
-
- HY-B1729S1
-
|
|
Isotope-Labeled Compounds
Oxidative Phosphorylation
Bacterial
Fungal
|
Infection
|
|
Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
- HY-B1444R
-
|
|
Reference Standards
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Isoconazole (nitrate) (Standard) is the analytical standard of Isoconazole (nitrate). This product is intended for research and analytical applications. Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
|
-
- HY-B1729S
-
|
|
Isotope-Labeled Compounds
Oxidative Phosphorylation
Bacterial
Fungal
|
Infection
|
|
Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol . Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
- HY-119555
-
|
|
Bacterial
|
Infection
|
|
Nifurpipone is an orally active broad-spectrum antimicrobial agent. Nifurpipone acts against Gram-positive and Gram-negative bacteria, and reduces bacterial loads in systemic, intramuscular and urinary tract infections in mouse models. Nifurpipone can be used in studies related to bacterial infections .
|
-
- HY-B0035
-
|
Sulfadimidine; Sulfadimerazine
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamethazine (Sulfadimidine) is an antimicrobial agent with blood-brain barrier permeability. Sulfamethazine is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine in animal product is set at 100 μg/kg .
|
-
- HY-W015820R
-
-
- HY-W145518
-
|
|
Environmental Pollutants
Antibiotic
Endogenous Metabolite
Bacterial
|
Infection
Cancer
|
|
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .
|
-
- HY-180414
-
|
|
Bacterial
Topoisomerase
|
Infection
|
|
Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research .
|
-
- HY-B1729R
-
|
|
Oxidative Phosphorylation
Reference Standards
Bacterial
Fungal
|
Infection
|
|
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
- HY-W728085
-
|
|
Bacterial
Antibiotic
Insecticide
Reactive Oxygen Species (ROS)
|
Infection
|
|
CPPD-Q is an antimicrobial agent and insecticide. CPPD-Q has an EC50 of 6.98 mg/L against Vibrio fischeri. At doses of 1 or 10 µg/mL, CPPD-Q exerts its insecticidal effect by inducing the production of reactive oxygen species (ROS) in the intestines of Caenorhabditis elegans .
|
-
- HY-A0090R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Nitrofurantoin (Standard) is the analytical standard of Nitrofurantoin. This product is intended for research and analytical applications. Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
- HY-W150903
-
|
p-Oxybenzoesaureheptylester
|
Fungal
Bacterial
|
Infection
|
|
N-Heptyl 4-hydroxybenzoate (p-Oxybenzoesaureheptylester) is an antimicrobial agent that inhibits S. aureus with MIC of 12.5 μg/mL. N-Heptyl 4-hydroxybenzoate also against plant pathogenic fungi, such as Alternaria brassicicola, F. solani, C. dematium and C. acutatum .
|
-
- HY-135842R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Aspoxicillin (Standard) is the analytical standard of Aspoxicillin. This product is intended for research and analytical applications. Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes .
|
-
- HY-B0126S
-
|
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Marbofloxacin-d8 is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-W392548
-
|
|
Bacterial
Fungal
|
Infection
|
|
1-O-4-Hydroxybenzoyl-glycerol is an antimicrobial agent against Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum (20 mM, maximum inhibition rate: 70%). 1-O-(4-Hydroxybenzoyl)-glycerol stimulates low skin irritation .
|
-
- HY-32865
-
|
|
Bacterial
Drug Intermediate
|
Infection
|
|
tert-Butyl 2,2,2-trichloroacetimidate is a tert-butylation reagent. tert-Butyl 2,2,2-trichloroacetimidate achieves mild, nonreversible tert-butylation of alcohols and phenols. tert-Butyl 2,2,2-trichloroacetimidate is used in the synthesis of antimicrobial agents .
|
-
- HY-N8432
-
|
|
Environmental Pollutants
Bacterial
Apoptosis
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis .
|
-
- HY-B0126AS
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Marbofloxacin-d8 (hydrochloride) is deuterium labeled Marbofloxacin (hydrochloride). Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-180521
-
|
|
Fungal
|
Infection
Cancer
|
|
Piroctone is a potent hydroxypyridone antimicrobial agent that shows remarkable activity against fungi including Candida species. Piroctone inhibits hyphal induction of Candida albicans. Piroctone can efficiently chelate intracellular iron to induce relevant cytotoxicity in neuroblastoma cells. Piroctone can be used for antimicrobial and neuroblastoma research .
|
-
- HY-10392R
-
|
PNU-100480 (Standard); U-100480 (Standard); PF-02341272 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Sutezolid (Standard) is the analytical standard of Sutezolid. This product is intended for research and analytical applications. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis[1][2].
|
-
- HY-N10495
-
|
|
Antibiotic
Bacterial
Topoisomerase
|
Infection
|
|
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .
|
-
- HY-N15595
-
|
|
Bacterial
Fungal
|
Infection
|
|
Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL .
|
-
- HY-106228
-
|
|
Fungal
Bacterial
Glutathione Peroxidase
|
Infection
|
|
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
|
-
- HY-123095
-
|
JBIR 100
|
Antibiotic
Bacterial
Proton Pump
|
Infection
Inflammation/Immunology
Endocrinology
|
|
TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis .
|
-
- HY-A0090S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Others
|
|
Nitrofurantoin- 13C3 is the 13C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
- HY-B0614BR
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Mafenide (hydrochloride) (Standard) is the analytical standard of Mafenide (hydrochloride). This product is intended for research and analytical applications. Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. Mafenide hydrochloride shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis[1][2].
|
-
- HY-139324
-
|
|
GSK-3
Amyloid-β
|
Neurological Disease
Cancer
|
|
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent .
|
-
- HY-152252
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antibacterial agent 133 (4l) is an antimicrobial agent that has shown anti-Candida activity, particularly through LMD enzyme inhibition. Antibacterial agent 133 shows MIC90 values of 1.95 μg/mL against Candida albicans ATCC 24433, Candida smoothis ATCC 90030 and Candida subtilis ATCC 22019 .
|
-
- HY-E70030
-
|
|
Bacterial
|
Infection
|
|
GlcNAc 1-P uridyltransferase (CjGlmU) is a sugar nucleotidyltransferase (SNT). GlcNAc 1-P uridyltransferase (CjGlmU) utilizes UTP and GlcNAc-1-P as its natural substrates, synthesizes UDP-GlcNAc. GlcNAc 1-P uridyltransferase (CjGlmU) has the potential for the research of antimicrobial agents .
|
-
- HY-B0126R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Marbofloxacin (Standard) is the analytical standard of Marbofloxacin. This product is intended for research and analytical applications. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
- HY-W587701
-
|
|
Bacterial
Antibiotic
|
|
|
Methacycline is a tetracycline antibiotic that inhibits bacterial protein synthesis. Methacycline is a potent inhibitor of epithelial-to-mesenchymal transition (EMT). Methacycline blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. Methacycline is an antimicrobial agent with potential for use in pulmonary fibrosis research .
|
-
- HY-10392S
-
|
PNU-100480-13C4; U-100480-13C4; PF-02341272-13C4
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
|
-
- HY-122955
-
|
|
Fungal
|
Infection
|
|
Xanthobaccin A is a potent antimicrobial agent that can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A exhibits activity against fungi, induces zoospore immobilization and lysis, inhibits mycelial growth. Xanthobaccin A can be used for the research of beet damping-off disease, bacterial and fungal infection .
|
-
- HY-P10539
-
|
|
Bacterial
|
Infection
|
|
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .
|
-
- HY-N7538
-
|
|
Bacterial
|
Infection
|
|
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .
|
-
- HY-W040795
-
|
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Infection
|
|
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .
|
-
- HY-15781R
-
|
|
Bacterial
Reference Standards
|
Infection
|
|
Morinidazole (Standard) is the analytical standard of Morinidazole. This product is intended for research and analytical applications. Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria .
|
-
- HY-N8461
-
|
3-Hydroxypropionaldehyde; 3-Hydroxypropanal
|
Bacterial
|
Infection
|
|
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates .
|
-
- HY-17593
-
|
CEM-101; OP-1068
|
Bacterial
Antibiotic
|
Infection
|
|
Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC50s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis .
|
-
- HY-N10473
-
|
|
Bacterial
Fungal
|
Infection
|
|
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe 3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .
|
-
- HY-112959
-
|
TD-6424
|
Antibiotic
Bacterial
|
Infection
|
|
Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria .
|
-
- HY-W838632
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Antibacterial agent 266 (Compound C5) is a plant pathogen inhibitor that disrupts bacterial integrity, with EC50 values of 24.1 μg/mL and 39.0 μg/mL against Xanthomonas oryzae pv oryzae (Xoo) and X. axonopodis pv citri (Xac), respectively. Antibacterial agent 266 can be used in the development of plant pathology and agricultural antimicrobial agents research .
|
-
- HY-170810
-
|
|
Bacterial
|
Infection
|
|
E.coli Gyrase B-IN-1 (Compound 10g) is a E.coli Gyrase B inhibitor with antibacterial activities. E.coli Gyrase B-IN-1 has potent inhibitory activity against E. coli, with a MIC value of 0.12 mM. E.coli Gyrase B-IN-1 is promising for research of antimicrobial agents .
|
-
- HY-14603
-
-
- HY-B0614A
-
|
|
Bacterial
Fungal
|
Infection
|
|
Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds .
|
-
- HY-W013076
-
|
tetra(decyl)ammonium bromide
|
Biochemical Assay Reagents
|
Others
|
|
Tetrakis(decyl)ammonium bromide is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and is used in various industrial and biomedical applications. Tetrakis(decyl)ammonium bromide is commonly used as an emulsifier, solubilizer and antimicrobial agent in personal care products, cleansers and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, facilitating the movement of reactants between immiscible phases.
|
-
- HY-178722
-
|
|
Fungal
Bacterial
|
Infection
|
|
Deferasirox methyl ester (compound 6a), a derivative of Deferasirox (HY-17359), is an antimicrobial agent. Deferasirox methyl ester exhibits activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger with MICs of 0.5, 4.0, 1.0, 4.0, and 2.0 μg/mL, respectively. Deferasirox methyl ester can be used for antimicrobial research .
|
-
- HY-105751
-
|
Kalamycin; U-19718
|
Antibiotic
Bacterial
Beta-lactamase
Fungal
|
Infection
|
|
Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .
|
-
- HY-N0987
-
|
|
Bacterial
|
Infection
|
|
1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone is an antimicrobial agent that can be isolated from the genus garcinia. 1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone inhibits S. aureus and B. cereus with MIC values of 128 μg/mL and 200 μg/mL, respectively .
|
-
- HY-P10556
-
|
|
Bacterial
|
Infection
|
|
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents .
|
-
- HY-149346
-
|
|
Bacterial
|
Infection
|
|
Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb), without cytotoxicity. Mtb-IN-2 significantly decreases colony-forming units (CFU) in spleen of murine tuberculosis models, and distinguishes both drug-sensitive and drug-resistant Mtb H37Rv strains. Mtb-IN-2 affects methionine metabolism but not folate pathway directly.
|
-
- HY-B0537A
-
|
MP-601205 dihydrochloride
|
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-B0537
-
|
MP-601205
|
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-P3179
-
|
|
Bacterial
|
Infection
|
|
1,3-β-Glucanase is one of the primary components in C. albicans biofilm extrapolymeric substance (EPS). 1,3-β-Glucanase can degrade β-1,3-glucan so as to disrupt the Candida biofilm matrix and increase the effect of the antimicrobial agent. 1,3-β-Glucanase can be used as an antibiofilm agent .
|
-
- HY-P4836A
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-N2552
-
|
|
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .
|
-
- HY-N8432R
-
|
|
Apoptosis
Reference Standards
Bacterial
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Dipyrithione (Standard) is the analytical standard of Dipyrithione (HY-N8432). This product is intended for research and analytical applications. Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis .
|
-
- HY-173238
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS). Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus .
|
-
- HY-B1814
-
|
Synkamin; Synkamin base
|
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages .
|
-
- HY-123508
-
|
|
Drug Metabolite
Bacterial
|
Infection
|
|
PD 131628 is an antimicrobial agent and active PD 131112 metabolite. PD 131628 is two- to four-fold more active than Ciprofloxacin (HY-B0356), inhibiting all strains of Staphylococcus aureus and Streptococcus pneumoniae. PD 131628 is very active against Neisseria spp., Haemophilus influenzae and Moraxella catarrhalis, with MIC90s ranging from 0.004 to 0.008 mg/L .
|
-
- HY-B0537C
-
|
MP-601205 dimesylate
|
Antibiotic
Parasite
Fungal
Phosphatase
Bacterial
|
Infection
Cancer
|
|
Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-113365
-
|
4-Cholesten-3-one
|
Endogenous Metabolite
|
Infection
Metabolic Disease
|
|
Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .
|
-
- HY-146811
-
|
|
Bacterial
|
Inflammation/Immunology
|
|
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model .
|
-
- HY-W106486
-
|
N,N-Dimethyl-N-2-propenyl-2-propen-1-aminium chloride
|
Biochemical Assay Reagents
|
Others
|
|
Diallyldimethylammonium chloride (60% in water) is a quaternary ammonium compound belonging to the class of alkylammonium salts. The compound is widely used as a cationic monomer in the production of water-soluble polymers, especially in the manufacture of flocculants and coagulants for water treatment processes. In addition, it can be used as an antimicrobial agent, surfactant or adhesive in various industrial applications. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including papermaking, textiles and personal care products.
|
-
- HY-143232
-
|
|
Fungal
Bacterial
|
Infection
Cancer
|
|
Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM .
|
-
- HY-Y1885
-
|
|
Biochemical Assay Reagents
Bacterial
SARS-CoV
|
Infection
|
|
Tetrasodium pyrophosphate is a chelating that can bind calcium and help improve olfaction. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H2O2 levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19 .
|
-
- HY-W039699
-
|
2-(4-Methylphenyl)propionic acid
|
COX
Bacterial
Drug Intermediate
|
Infection
|
|
2-(p-Tolyl) propanoic acid (2-(4-methylphenyl) propionic acid) acts as an Antimicrobial agent intermediate. 2-(p-Tolyl) propanoic acid inhibits COX-1 and COX-2 enzymes, with IC50 values of 38.23 μM and 64.30 μM, respectively. 2-(p-Tolyl) propanoic acid is applicable to research on E. coli, Enterococcus faecalis, Listeria monocytogenes, and Staphylococcus aureus .
|
-
- HY-W018574
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tetraoctylammonium bromide (TOAB) is a quaternary ammonium salt consisting of a positively charged tetraoctylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It is also used as a surfactant and dispersant in various industrial applications, for example in the production of coatings, adhesives and polymers. Additionally, Tetraoctylammonium bromide has been investigated for potential applications in energy storage devices and as an antimicrobial agent.
|
-
- HY-17593R
-
|
CEM-101 (Standard); OP-1068 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Solithromycin (Standard) is the analytical standard of Solithromycin. This product is intended for research and analytical applications. Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC50s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis .
|
-
- HY-B0537B
-
|
MP-601205 isethionate
|
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-W010790
-
|
|
Bacterial
Fungal
|
Infection
|
|
Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride is a quaternary ammonium silane monomer-based disinfectant/antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as fungicidal activity against Candida albicans in solution; it can form a hydrophobic glass coating that displays bactericidal activity against Gram-positive and Gram-negative bacteria but has limited fungicidal activity against Candida albicans .
|
-
![Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride](//file.medchemexpress.com/product_pic/hy-w010790.gif)
- HY-B0537R
-
|
MP-601205 (Standard)
|
Reference Standards
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-W013376
-
|
1-(Diphenylmethyl)piperazine; 1-Benzhydrylpiperazine
|
Antibiotic
Bacterial
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
|
Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents .
|
-
- HY-B0537AS
-
|
MP-601205-d4 dihydrochloride
|
Isotope-Labeled Compounds
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-W008974
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-(Dimethyl(octadecyl)ammonio)propane-1-sulfonate is a class of quaternary ammonium compounds. It is a surfactant and cationic detergent with amphiphilic properties and therefore useful in various industrial and biomedical applications. 3-(Dimethyl(octadecyl)ammonium)propane-1-sulfonate is commonly used as an emulsifier, solubilizer and antimicrobial agent in personal care products, detergents, textiles and pharmaceutical formulations. It is also used as a reagent in analytical chemistry, especially in the analysis of proteins and DNA.
|
-
- HY-162672
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 231 (derivative 8) is an antimicrobial agent against multidrug-resistant Helicobacter pylori (H. pylori) with a minimum inhibitory concentration of 0.25–0.5 μg/mL. Antibacterial agent 231 directly targets the protein transposase subunit SecA and the outer membrane protein assembly factor BamD to inhibit the trafficking and assembly of bacterial outer membrane proteins (OMPs). Antibacterial agent 231 can be used to study the effects of antibiotic treatment on intestinal microbial balance .
|
-
- HY-W716702
-
|
Lexamine M-13-d6; MAPD-d6
|
Isotope-Labeled Compounds
Fungal
Bacterial
Antibiotic
Biochemical Assay Reagents
Insecticide
|
Inflammation/Immunology
|
|
Aldox-d6 (Lexamine M-13-d6; MAPD-d6) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
|
-
- HY-W150903S
-
|
p-Oxybenzoesaureheptylester [German]-d4
|
Isotope-Labeled Compounds
Fungal
Bacterial
|
Infection
|
|
N-Heptyl 4-hydroxybenzoate-d4 is the deuterium labeled N-Heptyl 4-hydroxybenzoate (HY-W150903) . N-Heptyl 4-hydroxybenzoate (p-Oxybenzoesaureheptylester) is an antimicrobial agent that inhibits S. aureus with MIC of 12.5 μg/mL. N-Heptyl 4-hydroxybenzoate also against plant pathogenic fungi, such as Alternaria brassicicola, F. solani, C. dematium and C. acutatum .
|
-
- HY-147755
-
|
|
Bacterial
|
Infection
|
|
C16-K-cBB1 is a potent and selective antimicrobial agent for MRSA (Methicillin resistant Staphylococcus aureus), with a MIC of 1 µg/mL. C16-K-cBB1 has very good selectivity, as it has weak hemolytic activity. C16-K-cBB1 is able to kill MRSA cells in a matter of 120 min at a concentration of 12.5 μg/mL .
|
-
- HY-W013699
-
|
|
Environmental Pollutants
Antibiotic
Necroptosis
Bacterial
Apoptosis
|
Infection
|
|
Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-Y1316R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
Sodium benzoate (Standard) is the analytical standard of Sodium benzoate. This product is intended for research and analytical applications. Sodium benzoate can be used as an excipient, such as antimicrobial agent, preservative, lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-172109
-
|
|
DNA/RNA Synthesis
|
Infection
|
|
DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis .
|
-
- HY-119475
-
|
|
Bacterial
Insecticide
DNA/RNA Synthesis
|
Infection
|
|
Satranidazole is an orally active insecticide and antimicrobial agent with high electron affinity. Satranidazole forms reduced nitro intermediates, which interact with DNA, causing helix instability, strand breakage and release of thymidine derivatives. Satranidazole exhibits antitrichomonal activity against Trichomonas vaginalis and Trichomonas foetus, and antiamoebic activity in rodent models of hepatic amoebiasis and caecal amoebiasis. Satranidazole inhibits the replication of bacteriophage φX174 DNA. Satranidazole can be used in research related to caecal amoebiasis, trichomoniasis and anaerobic bacterial infections .
|
-
- HY-B1248A
-
|
|
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine acetate hydrate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine acetate hydrate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine acetate hydrate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine acetate hydrate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-Y1826
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
IITR01324 is an antimicrobial agent. IITR01324 has antimicrobial activity against Escherichia coli (MIC = 3.58 mg/L) and other Gram-negative bacteria (Shigella flexneri: MIC = 3.58 mg/L; Cronobacter sakazakii: MIC = 28.63 mg/L). IITR01324 exerts its antimicrobial activity by destroying bacterial DNA after activation of intracellular reductases. IITR01324 can be used to study the development of new antimicrobial drugs, especially against multidrug-resistant (MDR) pathogens .
|
-
- HY-131050
-
|
|
Bacterial
Fungal
|
Infection
|
|
Aspergillus niger-IN-1 (Compound 17), a derivative of thiazolidine-2,4-dione, acts as an antimicrobial agent. Aspergillus niger-IN-1 exhibited antimicrobial activity against various bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Candida albicans and Aspergillus niger, with MIC values of 11.3, 5.65, 11.3, 5.65, 5.65, 5.65, and 5.65 μM/mL, respectively .
|
-
- HY-B1248
-
Chlorhexidine
Maximum Cited Publications
13 Publications Verification
|
Environmental Pollutants
Antibiotic
Necroptosis
Bacterial
Apoptosis
|
Infection
|
|
Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-B1145
-
|
|
Environmental Pollutants
Antibiotic
Apoptosis
Bacterial
Necroptosis
|
Infection
|
|
Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-B0614AR
-
|
|
Reference Standards
Bacterial
Fungal
|
Infection
|
|
Mafenide (Acetate) (Standard) is the analytical standard of Mafenide Acetate (HY-B0614A). This product is intended for research and analytical applications. Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds .
|
-
- HY-162273
-
|
|
Bacterial
Smo
Gli
|
Infection
Cancer
|
|
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .
|
-
- HY-N2552R
-
|
|
Reference Standards
Pyruvate Kinase
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Vitamin K5 (hydrochloride) (Standard) is the analytical standard of Vitamin K5 (hydrochloride). This product is intended for research and analytical applications. Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages[1][2][3].
|
-
- HY-162142
-
|
|
Bacterial
Succinate Dehydrogenase
Reactive Oxygen Species (ROS)
|
Infection
|
|
BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM .
|
-
- HY-181282
-
|
|
Bacterial
|
Infection
|
|
MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus .
|
-
- HY-B0724A
-
|
T-3762; Pazufloxacin methanesulfonate; Pazufloxacin mesilate
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-B0724B
-
|
T3761
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-119475S
-
|
|
Isotope-Labeled Compounds
Insecticide
DNA/RNA Synthesis
Bacterial
|
Others
|
|
Satranidazole-d3 is the deuterium labeled Satranidazole. Satranidazole is an orally active insecticide and antimicrobial agent with high electron affinity. Satranidazole forms reduced nitro intermediates, which interact with DNA, causing helix instability, strand breakage and release of thymidine derivatives. Satranidazole exhibits antitrichomonal activity against Trichomonas vaginalis and Trichomonas foetus, and antiamoebic activity in rodent models of hepatic amoebiasis and caecal amoebiasis. Satranidazole inhibits the replication of bacteriophage φX174 DNA. Satranidazole can be used in research related to caecal amoebiasis, trichomoniasis and anaerobic bacterial infections.
|
-
- HY-B0537BR
-
|
MP-601205 isethionate (Standard)
|
Reference Standards
Parasite
Fungal
Phosphatase
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Pentamidine (isethionate) (Standard) is the analytical standard of Pentamidine (isethionate). This product is intended for research and analytical applications. Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
- HY-173192
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 272 (Compound Z22) is a potential antimicrobial agent targeting DNA and the DNA-topoisomerase II (DNA-Topo II) complex, exhibiting MIC values of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853, demonstrating potent antibacterial activity. This compound functions by intercalating with DNA base pairs to disrupt normal bacterial DNA function, making it suitable for research on bacterial infectious diseases .
|
-
- HY-B1145S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-W145053
-
|
Sodium chloro(4-methylbenzenesulfonyl)azanide hydrate
|
Factor Xa
Bacterial
|
Infection
|
|
ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) is a common reagent in various synthetic processes. It has been used as a reagent in aminohydroxylation and allylic amination reactions, a nitrogen source in aziridination reactions of alkenes and alkenes, and deprotection of sulfur groups in sulfur-containing compounds. It has been used as a reagent in the synthesis of factor Xa inhibitors. ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) (0.2% w/v) is also an antimicrobial agent that kills Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae.
|
-
- HY-115693
-
|
|
Bacterial
|
Infection
|
|
CAP 3 is a cholic acid-peptide conjugate (CAP) antimicrobial agent. CAP 3 effectively inhibits Gram-negative bacteria, with MIC99 (minimum inhibitory concentration for 99% bacterial killing) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae and Acinetobacter baumannii, respectively. CAP 3 exerts its antibacterial effects by disrupting the structural integrity of the bacterial lipopolysaccharide (LPS) outer membrane. CAP 3 rapidly kills bacteria, inhibits biofilm formation, and effectively combats drug-resistant strains and persistent bacterial infections .
|
-
- HY-114495
-
|
Cerulomycin; Caerulomycin
|
Fungal
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma .
|
-
- HY-B0608
-
|
|
Environmental Pollutants
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine digluconate (20% in water) is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine digluconate (20% in water) binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine digluconate (20% in water) has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine digluconate (20% in water) can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-B1248R
-
|
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine (Standard) is the analytical standard of Chlorhexidine (HY-B1248). This product is intended for research and analytical applications. Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-B1145R
-
|
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine dihydrochloride (Standard) is the analytical standard of Chlorhexidine dihydrochloride (HY-B1145). This product is intended for research and analytical applications. Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-W013699R
-
|
|
Reference Standards
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine diacetate (Standard) is the analytical standard of Chlorhexidine diacetate (HY-W013699). This product is intended for research and analytical applications. Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-W738281
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Necroptosis
Apoptosis
|
Infection
|
|
Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248) . Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
- HY-149155
-
|
|
Bacterial
|
Infection
|
|
o-Cymen-5-ol is a broad-spectrum antimicrobial agent with direct antimicrobial activity. o-Cymen-5-ol showed effective minimum inhibitory concentrations (MICs) against a variety of bacteria and fungi, such as Streptococcus mutans and Candida albicans. The combination of o-Cymen-5-ol and zinc showed synergistic effects, enhancing the inhibitory effect against oral pathogens. o-Cymen-5-ol was able to inhibit the glycolysis process and co-enhanced this effect with zinc. o-Cymen-5-ol showed a stronger antibacterial effect in toothpaste than placebo .
|
-
- HY-Y1826R
-
|
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
IITR01324 (Standard) is the analytical standard of IITR01324. This product is intended for research and analytical applications. IITR01324 is an antimicrobial agent. IITR01324 has antimicrobial activity against Escherichia coli (MIC=3.58 mg/L) and other Gram-negative bacteria (Shigella flexneri: MIC=3.58 mg/L; Cronobacter sakazakii: MIC=28.63 mg/L). IITR01324 exerts its antimicrobial activity by destroying bacterial DNA after activation of intracellular reductases. IITR01324 can be used to study the development of new antimicrobial drugs, especially against multidrug-resistant (MDR) pathogens .
|
-
- HY-B0724AR
-
|
T-3762 (Standard); Pazufloxacin methanesulfonate (Standard); Pazufloxacin mesilate (Standard)
|
Reference Standards
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Pazufloxacin (mesylate) (Standard) is the analytical standard of Pazufloxacin mesylate (HY-B0724A). This product is intended for research and analytical applications. Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-W014316
-
|
|
Bacterial
Fungal
|
Infection
|
|
5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
|
-
- HY-B0724BS
-
|
T3761-d4
|
Isotope-Labeled Compounds
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Pazufloxacin-d4 is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
- HY-118773
-
|
A22 hydrochloride
|
Bacterial
|
Infection
|
|
MreB Perturbing Compound A22 hydrochloride (A22 hydrochloride) is a reversible MreB inhibitor and antimicrobial agent that exhibits bacteriostatic activity against Escherichia coli, with low activity against Gram-positive bacteria. MreB Perturbing Compound A22 hydrochloride rapidly and reversally delocalizes MreB from the helical/circular structures in cells, impairs MreB function, and reduces the binding of MreB to the chromosomal region proximal to the replication origin. MreB Perturbing Compound A22 hydrochloride alters the cell morphology of caulobacters to round/lemon-shaped, slows caulobacter growth, blocks their cell division, and induces the formation of spherical morphology, asymmetric division, and anucleate cells in Escherichia coli. MreB Perturbing Compound A22 hydrochloride is used for studies related to bacterial rod-shaped morphology determination, chromosome segregation, and cell division mechanisms .
|
-
- HY-168204
-
|
|
Bacterial
Fungal
|
Infection
|
|
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .
|
-
- HY-N8389
-
|
|
Bacterial
Fungal
PAK
Akt
STAT
PD-1/PD-L1
Apoptosis
CCR
|
Infection
Cancer
|
|
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .
|
-
- HY-W014316R
-
|
|
Reference Standards
Bacterial
Fungal
|
Infection
|
|
5-Bromo-5-nitro-1,3-dioxane (Standard) is the analytical standard of 5-Bromo-5-nitro-1,3-dioxane (HY-W014316). This product is intended for research and analytical applications. 5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .
|
-
- HY-118773R
-
|
A22 hydrochloride (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
MreB Perturbing Compound A22 hydrochloride (Standard) is the analytical standard for MreB Perturbing Compound A22 hydrochloride (HY-118773). This product is intended for research and analytical applications. MreB Perturbing Compound A22 hydrochloride (A22 hydrochloride) is a reversible MreB inhibitor and antimicrobial agent that exhibits bacteriostatic activity against Escherichia coli, with low activity against Gram-positive bacteria. MreB Perturbing Compound A22 hydrochloride rapidly and reversally delocalizes MreB from the helical/circular structures in cells, impairs MreB function, and reduces the binding of MreB to the chromosomal region proximal to the replication origin. MreB Perturbing Compound A22 hydrochloride alters the cell morphology of caulobacters to round/lemon-shaped, slows caulobacter growth, blocks their cell division, and induces the formation of spherical morphology, asymmetric division, and anucleate cells in Escherichia coli. MreB Perturbing Compound A22 hydrochloride is used for studies related to bacterial rod-shaped morphology determination, chromosome segregation, and cell division mechanisms .
|
-
- HY-W006886
-
|
|
Amino Acid Derivatives
|
Others
|
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.
|
-
- HY-N15140
-
|
|
Drug Isomer
Bacterial
Fungal
Carboxypeptidase
|
Infection
Cancer
|
|
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
|
-
- HY-162775
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
TST1N-224 is a potent response regulator VraRC inhibitor. TST1N-224 can disrupt VraRC-DNA complex formation (IC50=60.2 μM). TST1N-224 exhibits interference with VraRC binding to its cognate DNA through a fast-on-fast-off binding mechanism (KD=23.4 μM). TST1N-224 predominantly interacts with the α9- and α10-helixes of the DNA-binding domain of VraR. TST1N-224 inhibits the growths of S. aureus (SA; MIC>126 μM), Methicillin-resistant S. aureus (MRSA; MIC>126 μM), and Vancomycin-intermediate S. aureus (VISA; MIC=63 μM). TST1N-224, an antimicrobial agent, evidently enhances the susceptibility of VISA to both Vancomycin (HY-B0671) and Methicillin (HY-B0974) .
|
-
-
-
HY-L084
-
|
|
914 compounds
|
|
Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.
MCE provides a unique collection of 914 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.
|
-
-
HY-L049
-
|
|
1,904 compounds
|
|
Antibacterial agents are a group of materials that fight against pathogenic bacteria. Thus, by killing or reducing the metabolic activity of bacteria, their pathogenic effect in the biological environments will be minimized. The most widely used antibacterial agents exert their effects on bacterial cell wall synthesis, protein synthesis, DNA replication and metabolic pathways. However, resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. The main mechanisms of resistance are limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. Therefore, it is an urgent need to develop new drugs targeted at resistant organisms.
MCE offers a unique collection of 1,904 compounds with validated antibacterial activities. MCE antibacterial compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.
|
| Cat. No. |
Product Name |
Type |
-
- HY-Y1885
-
|
|
Biochemical Assay Reagents
|
|
Tetrasodium pyrophosphate is a chelating that can bind calcium and help improve olfaction. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H2O2 levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19 .
|
-
- HY-W018574
-
|
|
Biochemical Assay Reagents
|
|
Tetraoctylammonium bromide (TOAB) is a quaternary ammonium salt consisting of a positively charged tetraoctylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It is also used as a surfactant and dispersant in various industrial applications, for example in the production of coatings, adhesives and polymers. Additionally, Tetraoctylammonium bromide has been investigated for potential applications in energy storage devices and as an antimicrobial agent.
|
-
- HY-40040
-
|
|
Biochemical Assay Reagents
|
|
(S)-1-Boc-3-methylpiperazine is a synthetic intermediate for indole-piperazine hybrid antimicrobial agent preparation. (S)-1-Boc-3-methylpiperazine can be used for research on bacterial infection and fungal infection .
|
-
- HY-W013076
-
|
tetra(decyl)ammonium bromide
|
Biochemical Assay Reagents
|
|
Tetrakis(decyl)ammonium bromide is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and is used in various industrial and biomedical applications. Tetrakis(decyl)ammonium bromide is commonly used as an emulsifier, solubilizer and antimicrobial agent in personal care products, cleansers and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, facilitating the movement of reactants between immiscible phases.
|
-
- HY-W106486
-
|
N,N-Dimethyl-N-2-propenyl-2-propen-1-aminium chloride
|
Biochemical Assay Reagents
|
|
Diallyldimethylammonium chloride (60% in water) is a quaternary ammonium compound belonging to the class of alkylammonium salts. The compound is widely used as a cationic monomer in the production of water-soluble polymers, especially in the manufacture of flocculants and coagulants for water treatment processes. In addition, it can be used as an antimicrobial agent, surfactant or adhesive in various industrial applications. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including papermaking, textiles and personal care products.
|
-
- HY-W008974
-
|
|
Biochemical Assay Reagents
|
|
3-(Dimethyl(octadecyl)ammonio)propane-1-sulfonate is a class of quaternary ammonium compounds. It is a surfactant and cationic detergent with amphiphilic properties and therefore useful in various industrial and biomedical applications. 3-(Dimethyl(octadecyl)ammonium)propane-1-sulfonate is commonly used as an emulsifier, solubilizer and antimicrobial agent in personal care products, detergents, textiles and pharmaceutical formulations. It is also used as a reagent in analytical chemistry, especially in the analysis of proteins and DNA.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-106228
-
|
|
Fungal
Bacterial
Glutathione Peroxidase
|
Infection
|
|
HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses .
|
-
- HY-P3494
-
|
|
Hepcidin
Bacterial
|
Infection
Inflammation/Immunology
|
|
Hepcidin-25 (human) is an iron metabolism regulator and Antimicrobial agent. Hepcidin-25 (human) exerts anti-inflammatory and antimicrobial activities by regulating iron-mediated oxidative damage .
|
-
- HY-W006886
-
|
|
Amino Acid Derivatives
|
Others
|
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.
|
-
- HY-P4836A
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-P11239
-
-
- HY-P3494B
-
|
|
Hepcidin
Bacterial
|
Infection
Inflammation/Immunology
|
|
Hepcidin-25 (human) TFA is an iron metabolism modulator and Antimicrobial agent. Hepcidin-25 (human) TFA shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury .
|
-
- HY-P4836
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-P10556
-
|
|
Bacterial
|
Infection
|
|
(KFF)3K is a cell penetrating peptide that can promote the absorption of other antibiotics by disrupting the outer membrane of bacteria. (KFF)3K can be introduced into a hydrocarbon scaffold to induce its antibacterial properties, making it an effective antimicrobial peptide. (KFF)3K can be used in the development of new antimicrobial agents .
|
-
- HY-P3417
-
|
|
Bacterial
|
Infection
|
|
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .
|
-
- HY-P10539
-
|
|
Bacterial
|
Infection
|
|
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N8461
-
-
-
- HY-113365
-
-
-
- HY-B1729
-
-
-
- HY-W145518
-
-
-
- HY-N10473
-
|
|
Microorganisms
Cyclopeptides
|
Bacterial
Fungal
|
|
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe 3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .
|
-
-
- HY-114495
-
-
-
- HY-103643
-
-
-
- HY-N8432
-
-
-
- HY-B1729R
-
|
|
Microorganisms
Source Classification
|
Oxidative Phosphorylation
Reference Standards
Bacterial
Fungal
|
|
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
-
- HY-N10495
-
-
-
- HY-W040795
-
-
-
- HY-N8389
-
|
|
Structural Classification
Terpenoids
Sesquiterpenes
Myrtaceae
Plants
Eucalyptus globulus Labill.
Source Classification
|
Bacterial
Fungal
PAK
Akt
STAT
PD-1/PD-L1
Apoptosis
CCR
|
|
Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .
|
-
-
- HY-N9987
-
-
-
- HY-122955
-
-
-
- HY-W452285
-
-
-
- HY-N9947
-
-
-
- HY-105751
-
|
Kalamycin; U-19718
|
Microorganisms
Antibiotics
Other Antibiotics
Source Classification
|
Antibiotic
Bacterial
Beta-lactamase
Fungal
|
|
Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .
|
-
-
- HY-N12460
-
-
-
- HY-N7747
-
-
-
- HY-125676
-
-
-
- HY-N3602
-
-
-
- HY-126462
-
-
-
- HY-W015820R
-
-
-
- HY-W392548
-
-
-
- HY-N15595
-
|
|
Natural Products
Microorganisms
Source Classification
|
Bacterial
Fungal
|
|
Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL .
|
-
-
- HY-123095
-
-
-
- HY-N7538
-
|
|
Microorganisms
Ketones, Aldehydes, Acids
Source Classification
|
Bacterial
|
|
Dealanylalahopcin is an antimicrobial agent that can be isolated from the culture filtrate of Streptomyces leucoderma subsp. ochraceus. Dealanylalahopcin can also be synthesized by enzymatic hydrolysis of alahopcin by microbial α-amino acid ester hydrolases. Dealanylalahopcin has weak antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibits moderate inhibition of collagen prolyl hydroxylase .
|
-
-
- HY-N0987
-
-
-
- HY-N19815
-
-
-
- HY-N16692
-
-
-
- HY-N19688
-
-
-
- HY-N12752
-
-
-
- HY-N8432R
-
-
-
- HY-N15140
-
|
|
Structural Classification
Natural Products
Cupressaceae
Ketones, Aldehydes, Acids
Plants
Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.
Source Classification
|
Drug Isomer
Bacterial
Fungal
Carboxypeptidase
|
|
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N0172S
-
|
|
|
Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .
|
-
-
- HY-B0537AS
-
|
|
|
Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
|
-
-
- HY-B1145S
-
|
|
|
Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
-
- HY-B1267S1
-
|
|
|
Sulfaguanidine- 13C6 is the 13C6 labeled Sulfaguanidine. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.
|
-
-
- HY-A0090S
-
|
|
|
Nitrofurantoin- 13C3 is the 13C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
-
- HY-W150903S
-
|
|
|
N-Heptyl 4-hydroxybenzoate-d4 is the deuterium labeled N-Heptyl 4-hydroxybenzoate (HY-W150903) . N-Heptyl 4-hydroxybenzoate (p-Oxybenzoesaureheptylester) is an antimicrobial agent that inhibits S. aureus with MIC of 12.5 μg/mL. N-Heptyl 4-hydroxybenzoate also against plant pathogenic fungi, such as Alternaria brassicicola, F. solani, C. dematium and C. acutatum .
|
-
-
- HY-B0724BS
-
|
|
|
Pazufloxacin-d4 is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .
|
-
-
- HY-121272AS
-
|
|
|
Difloxacin-d3 (hydrochloride trihydrate) is a deuterium labeled Difloxacin. Difloxacin is an antimicrobial agent .
|
-
-
- HY-B0343S
-
|
|
|
Sarafloxacin-d8 is the deuterium labeled Sarafloxacin(HY-B0343).Sarafloxacin (A-56620) is a fluoroquinolone antimicrobial agent .
|
-
-
- HY-W744147
-
|
|
|
4-Glycidyloxycarbazole-d5 is the deuterium labeled 4-Glycidyloxycarbazole (HY-W013429). 4-Glycidyloxycarbazole (compound 8) is an antimicrobial agent that disrupts bacterial biofilm formation .
|
-
-
- HY-B1729S1
-
|
|
|
Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
-
- HY-B1729S
-
|
|
|
Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol . Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
-
- HY-B0126S
-
|
|
|
Marbofloxacin-d8 is the deuterium labeled Marbofloxacin. Marbofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
-
- HY-B0126AS
-
|
|
|
Marbofloxacin-d8 (hydrochloride) is deuterium labeled Marbofloxacin (hydrochloride). Marbofloxacin hydrochloride is a third generation fluoroquinolone and orally active antimicrobial agent, which has a broad spectrum bactericidal activity and good efficacy. Marbofloxacin hydrochloride can be used for the research of infections by Gram-positive and Gram-negative bacteria and Mycoplasma .
|
-
-
- HY-10392S
-
|
|
|
Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
|
-
-
- HY-W716702
-
|
|
|
Aldox-d6 (Lexamine M-13-d6; MAPD-d6) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .
|
-
-
- HY-W738281
-
|
|
|
Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248) . Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .
|
-
-
- HY-119475S
-
|
|
|
Satranidazole-d3 is the deuterium labeled Satranidazole. Satranidazole is an orally active insecticide and antimicrobial agent with high electron affinity. Satranidazole forms reduced nitro intermediates, which interact with DNA, causing helix instability, strand breakage and release of thymidine derivatives. Satranidazole exhibits antitrichomonal activity against Trichomonas vaginalis and Trichomonas foetus, and antiamoebic activity in rodent models of hepatic amoebiasis and caecal amoebiasis. Satranidazole inhibits the replication of bacteriophage φX174 DNA. Satranidazole can be used in research related to caecal amoebiasis, trichomoniasis and anaerobic bacterial infections.
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-Y1326
-
|
|
|
Antioxidants
Preservatives
|
|
Sodium metabisulfite, a sulfite salt, is used as an antioxidant and antimicrobial agent in a variety of drugs and functions as a preservative in many food preparations .
|
-
- HY-B2232
-
|
Alkyldimethylbenzylammonium chloride
|
|
Solubilizing Agents
|
|
Benzalkonium (Alkyldimethylbenzylammonium) chloride (51% in water) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (51% in water) is toxic .
|
-
- HY-W145518
-
|
|
|
Emulsifiers
Thickeners
|
|
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .
|
-
- HY-W089856
-
|
|
|
Preservatives
|
|
Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries .
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent:
![Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride](http://file.medchemexpress.com/product_pic/hy-w010790.gif)
