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antiproliferative

" in MedChemExpress (MCE) Product Catalog:

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156777

    Others Cancer
    Antiproliferative agent-36 (compound 8i) is a benzothiazolyl hydrazones derived compound with antiproliferative activity. Antiproliferative agent-36 has a broad-spectrum anticancer activity .
    <em>Antiproliferative</em> agent-36
  • HY-128224

    Others Cancer
    Antiproliferative agent-13 (compound 16c) shows an antiproliferative activity against human A375 cells with an IC50 value of 32.7 nM. Antiproliferative agent-13 can be used for the research of cancer .
    <em>Antiproliferative</em> agent-13
  • HY-147776

    MDM-2/p53 Cancer
    Antiproliferative agent-8 (Compound 5a) is an anti-cancer agent. Antiproliferative against-8 has antiproliferative activity. Antiproliferative agent-8 significantly increases the P53 levels .
    <em>Antiproliferative</em> agent-8
  • HY-142085

    Others Cancer
    Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities .
    <em>Antiproliferative</em> agent-20
  • HY-155402

    Caspase Apoptosis Others
    Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC50 value of 12.54 μM .
    <em>Antiproliferative</em> agent-42
  • HY-146103

    Apoptosis Reactive Oxygen Species Cancer
    Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis .
    <em>Antiproliferative</em> agent-7
  • HY-145866

    Others Cancer
    Antiproliferative agent-3 (comp 4) shows the highest potency for MCF-7 cells (IC50 = 0.19 nM) .
    <em>Antiproliferative</em> agent-3
  • HY-150968

    Apoptosis Cancer
    Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer .
    <em>Antiproliferative</em> agent-11
  • HY-155051

    Apoptosis Histone Methyltransferase Cancer
    Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes .
    <em>Antiproliferative</em> agent-25
  • HY-155112

    Microtubule/Tubulin FLT3 Bcr-Abl Cancer
    Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation .
    <em>Antiproliferative</em> agent-30
  • HY-146454

    Others Cancer
    Antiproliferative agent-6 (compound 8a) is a potent antitumor agent. Antiproliferative agent-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively .
    <em>Antiproliferative</em> agent-6
  • HY-156879

    Others Cancer
    Antiproliferative agent-40 (Compound 9) inhibits proliferation of HT1080 and MCF-7 with IC50s of 52 and 8.2 μM respectively .
    <em>Antiproliferative</em> agent-40
  • HY-W471938

    Others Cancer
    Antiproliferative agent-35 (Compound 4) inhibits the proliferation of B16 and A549 cells, with IC50s of 13.2 and 9.2 μM resspectively .
    <em>Antiproliferative</em> agent-35
  • HY-156843

    Others Cancer
    Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .
    <em>Antiproliferative</em> agent-38
  • HY-155413

    Apoptosis Cancer
    Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase .
    <em>Antiproliferative</em> agent-43
  • HY-156878

    Others Cancer
    Antiproliferative agent-39 (Compound 12) inhibits proliferation of A549, SNU-638, Col2, HT1080, MCF-7 with IC50s of 11, 25, 14, 11, 6.3 μM respectively .
    <em>Antiproliferative</em> agent-39
  • HY-152090

    Bacterial Sirtuin Infection Cancer
    Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity .
    <em>Antiproliferative</em> agent-17
  • HY-161089

    Others Cancer
    Antiproliferative agent-45 (compound 9) is a prodrug. Antiproliferative agent-45 exhibits significant anti-proliferative effects for human pancreatic cells in hypoxia but fewer effects in normoxia. Antiproliferative agent-45 can be used for cancer research .
    <em>Antiproliferative</em> agent-45
  • HY-155380

    Others Others
    Antiproliferative agent-41 (compound 14) is a antiproliferative agent indanorine .
    <em>Antiproliferative</em> agent-41
  • HY-152091

    Fungal Infection Cancer
    Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity .
    <em>Antiproliferative</em> agent-18
  • HY-N8676

    Others Cancer
    Antiproliferative agent-29 (Compound 16) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-29 has antiproliferative activity and has potential for cancer research .
    <em>Antiproliferative</em> agent-29
  • HY-N8677

    Others Cancer
    Antiproliferative agent-28 (Compound 14) is a triterpenoid isolated from the seeds of Peganum harmala L. Antiproliferative agent-28 has antiproliferative activity and has potential for cancer research .
    <em>Antiproliferative</em> agent-28
  • HY-158016

    EGFR Apoptosis Cancer
    Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS .
    <em>Antiproliferative</em> agent-49
  • HY-155069

    Apoptosis Cancer
    Antiproliferative agent-27 (compound 11) is an antiproliferative agent that significantly reduces the number of tumor cell colonies and induces apoptosis. Antiproliferative agent-27 has the potential to be used in the study of cancer .
    <em>Antiproliferative</em> agent-27
  • HY-148265

    Microtubule/Tubulin Cancer
    Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle .
    <em>Antiproliferative</em> agent-14
  • HY-146354

    Apoptosis Reactive Oxygen Species Cancer
    Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity .
    <em>Antiproliferative</em> agent-4
  • HY-155127

    Others Cancer
    Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL .
    <em>Antiproliferative</em> agent-33
  • HY-W278944

    Others Cancer
    Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .
    <em>Antiproliferative</em> agent-15
  • HY-152099

    Apoptosis Cancer
    Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase .
    <em>Antiproliferative</em> agent-19
  • HY-162078

    Casein Kinase Cancer
    Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC50 value of 5.75 μM on the U87 cell line .
    <em>Antiproliferative</em> agent-46
  • HY-163381

    Others Cancer
    Antiproliferative agent-48 (compound PC-A1) shows selective antiproliferative activity against triple-negative breast cancer (TNBC) cells .
    <em>Antiproliferative</em> agent-48
  • HY-156183

    Others Cancer
    Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle .
    <em>Antiproliferative</em> agent-37
  • HY-158018

    EGFR Cancer
    Antiproliferative agent-50 (compound 10b) is EGFR-TK inhibitor with the IC50 of 0.16 μM. Antiproliferative agent-50 inhibits cell growth .
    <em>Antiproliferative</em> agent-50
  • HY-146390

    Autophagy Reactive Oxygen Species Cancer
    Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer .
    <em>Antiproliferative</em> agent-5
  • HY-152945

    NF-κB Cancer
    Antiproliferative agent-22 (compound 2) is an anticancer agent. Antiproliferative agent-22 shoes anti-proliferative activities against MCF-7, MDA-MB-231 and MDA-MB-468 cells with IC50 values of 6.2 μM, 3.3 μM and 3.3 μM, respectively .
    <em>Antiproliferative</em> agent-22
  • HY-155055

    Others Cancer
    Antiproliferative agent-26 (compound 4g) is an antiproliferative agent with much broad range of activity targeting Leukemia, CNS, Melanoma, Renal and Breast (at the concentration of 10 μM). Antiproliferative agent-26 inhibits colony forming and arrests cell cycle at G1 phase/S phase at 5 μM and 25 μM, respectively .
    <em>Antiproliferative</em> agent-26
  • HY-155124

    Apoptosis Cancer
    Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma .
    <em>Antiproliferative</em> agent-32
  • HY-148453

    Others Cancer
    Antiproliferative agent-16 is an indolyl hydrazide-hydrazone compound with anticancer activity. Antiproliferative agent-16 exhibits specificity toward breast cancer cells (IC50 of 6.94 μM for MCF-7 cells) .
    <em>Antiproliferative</em> agent-16
  • HY-149918

    Microtubule/Tubulin Apoptosis Cancer
    Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .
    <em>Antiproliferative</em> agent-23
  • HY-161013

    Others Others
    Antiproliferative agent-44 (compound 3) is a potent inhibitor of proliferation, with the IC50 values ranging from 2.02 to 1.61 μM .
    <em>Antiproliferative</em> agent-44
  • HY-155178

    EGFR Cancer
    Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT. Antiproliferative agent-34 also inhibits JAK2, ROS1, FLT3, FLT4, PDGFRα with IC50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement (IC50 values < 10 nM) under hypoxic condition .
    <em>Antiproliferative</em> agent-34
  • HY-150966

    Mitochondrial Metabolism
    Antiproliferative agent-10 (compound 8) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .
    <em>Antiproliferative</em> agent-10
  • HY-150969

    Mitochondrial Metabolism Cancer
    Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .
    <em>Antiproliferative</em> agent-12
  • HY-N3355

    Others Cancer
    Lupeolic acid can be isolated from Boswellia sacra. Lupeolic acid has anti-proliferative activity and can be used in cancer research .
    Lupeolic acid
  • HY-N11916

    Others Cancer
    Kadsuphilin A can be extracted from Kadsura coccinea (Lem.) and has weak antiproliferative activity .
    Kadsuphilin A
  • HY-N3428

    Others Cancer
    Kamebanin can be isolated from the leaves of Isodon weisiensis C. Y. Wu. Kamebanin has anti-proliferative activity and can be used in cancer research .
    Kamebanin
  • HY-N12282

    Others Cancer
    Isovitexin 2′′-O-rhamnoside, a phenolic, has antioxidant and antiproliferative activities .
    Isovitexin 2′′-O-rhamnoside
  • HY-80013B

    CDK Cancer
    (E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect .
    (E/Z)-THZ1 dihydrochloride
  • HY-148816

    Calcium Channel Cancer
    SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer .
    SG-094
  • HY-156336

    Polo-like Kinase (PLK) Cancer
    PLK1-IN-7 (compound 30e) is a potent PLK1 inhibitor, with an IC50 of 0.66 nM. PLK1-IN-7 exhibits antiproliferative and antitumor activities .
    PLK1-IN-7