2. Search Result
Search Result
Results for "

antitubercular

" in MedChemExpress (MCE) Product Catalog:

69

Inhibitors & Agonists

9

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151960
    Antitubercular agent-36

    		Bacterial Infection
    Antitubercular agent-36 (compound 53) is an antitubercular agent. Antitubercular agent-36 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL. Antitubercular agent-36 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-36
  • HY-144722
    Antitubercular agent-12

    		Bacterial Infection
    Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .
    <em>Antitubercular</em> agent-12
  • HY-151958
    Antitubercular agent-35

    		Bacterial Infection
    Antitubercular agent-35 (compound 42l) is an antitubercular agent. Antitubercular agent-35 inhibits the growth of MtbH37Rv and M. Marinum with MIC90 values of 1.25 and 2 μg/mL, respectively. Antitubercular agent-35 shows the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent-35 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-35
  • HY-146107
    Antitubercular agent-23

    		Bacterial Fungal Infection
    Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
    <em>Antitubercular</em> agent-23
  • HY-146106
    Antitubercular agent-22

    		Bacterial Fungal Infection
    Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
    <em>Antitubercular</em> agent-22
  • HY-151957
    Antitubercular agent 34

    		Bacterial Infection
    Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent 34
  • HY-151339
    Antitubercular agent-31

    		Bacterial Infection
    Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM .
    <em>Antitubercular</em> agent-31
  • HY-155190
    Antitubercular agent-39

    		Bacterial Infection
    Antitubercular agent-39 (Compound P1) is a potent antitubercular agent. Antitubercular agent-39 is active against drug-resistant strains and drug-susceptible clinical isolates. Antitubercular agent-39 inhibits Mtb strain H37Rv with a MIC less than 1 μM .
    <em>Antitubercular</em> agent-39
  • HY-144723
    Antitubercular agent-13

    		Bacterial Infection
    Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 µg/mL and 1.851 µg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability .
    <em>Antitubercular</em> agent-13
  • HY-146051
    Antitubercular agent-18

    		Bacterial Infection
    Antitubercular agent-18 (Compound 9a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-18 shows highly selective antimycobacterial effects .
    <em>Antitubercular</em> agent-18
  • HY-146050
    Antitubercular agent-17

    		Bacterial Infection
    Antitubercular agent-17 (Compound 8a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-17 shows highly selective antimycobacterial effects .
    <em>Antitubercular</em> agent-17
  • HY-163069
    Antitubercular agent-43

    		Bacterial Infection
    Antitubercular agent-43 (compound A11) is an orally active and potent antitubercular agent. Antitubercular agent-43 shows highly metabolic stability against human and mouse cytochrome P450 enzymes. Antitubercular agent-43 exhibits bactericidal efficacy in acute TB infection mouse model .
    <em>Antitubercular</em> agent-43
  • HY-163033
    Antitubercular agent-42

    		Bacterial Infection
    Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC90 = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .
    <em>Antitubercular</em> agent-42
  • HY-151340
    Antitubercular agent-32

    		Bacterial Infection
    Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM) .
    <em>Antitubercular</em> agent-32
  • HY-148111
    Antitubercular agent-33

    		Bacterial Infection
    Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .
    <em>Antitubercular</em> agent-33
  • HY-132928
    Antitubercular agent-10

    		Bacterial Infection
    Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.
    <em>Antitubercular</em> agent-10
  • HY-144721
    Antitubercular agent-11

    		Bacterial Infection
    Antitubercular agent-11 (Compound 1e) is an antitubercular agent. Antitubercular agent-11 with a bulkier electron-donating group (Bu-t) demonstrated the best MIC value of 0.060 μg/mL .
    <em>Antitubercular</em> agent-11
  • HY-149857
    Antitubercular agent-37

    		Bacterial Infection
    Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-37
  • HY-146496
    Antitubercular agent-20

    		Bacterial Infection
    Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .
    <em>Antitubercular</em> agent-20
  • HY-147505
    Antitubercular agent-21

    		Bacterial Fungal Infection
    Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H37Rv. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .
    <em>Antitubercular</em> agent-21
  • HY-132910
    Antitubercular agent-9

    		Bacterial Infection
    Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.
    <em>Antitubercular</em> agent-9
  • HY-156022
    Antitubercular agent-41

    		Bacterial Neurological Disease
    Antitubercular agent-41 (Compound 106) is an antitubercular agent that can be used in the study of Mycobacterium tuberculosis infection .
    <em>Antitubercular</em> agent-41
  • HY-146495
    Antitubercular agent-19

    		Bacterial Infection
    Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .
    <em>Antitubercular</em> agent-19
  • HY-146555
    Antitubercular agent-14

    		Bacterial Infection
    Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .
    <em>Antitubercular</em> agent-14
  • HY-146120
    Antitubercular agent-25

    		Bacterial Infection
    Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC50 of 0.42 μM and an intracellular IC50 of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .
    <em>Antitubercular</em> agent-25
  • HY-147884
    Antitubercular agent-28

    		Bacterial Infection
    Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC50 value of 1.5 µM, an MIC value of 4.5 µM, an IC90 value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .
    <em>Antitubercular</em> agent-28
  • HY-147883
    Antitubercular agent-27

    		Bacterial Infection
    Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC50 value of 3.2 µM, an MIC value of 7.8 µM, an IC90 value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .
    <em>Antitubercular</em> agent-27
  • HY-146121
    Antitubercular agent-26

    		Bacterial Infection
    Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC50 of 0.50 μM and an intracellular IC50 of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .
    <em>Antitubercular</em> agent-26
  • HY-155067
    Antitubercular agent-38

    		Bacterial Infection
    Antitubercular agent-38 is an orally active Benzothiazinones (BTZs) derivate, with potent antituberculosis activity. Antitubercular agent-38 exhibits low cardiac toxicity, low cell cytotoxicity .
    <em>Antitubercular</em> agent-38
  • HY-162094
    Antitubercular agent-44

    		Bacterial Infection
    Antitubercular agent-44 (compound 21b) has anti-tuberculosis (H37Rv MIC = 0.06 μM). Antitubercular agent-44 has oral activity .
    <em>Antitubercular</em> agent-44
  • HY-146119
    Antitubercular agent-24

    		Bacterial Infection
    Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM against M. tuberculosis H37Rv .
    <em>Antitubercular</em> agent-24
  • HY-151236
    Antitubercular agent-30

    		Bacterial Infection
    Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). Antitubercular agent-30 has little cytotoxic effect on murine macrophage cells (LD85=~100 μg/mL) .
    <em>Antitubercular</em> agent-30
  • HY-146556
    Antitubercular agent-15

    		Bacterial Infection
    Antitubercular agent-15 (Compound 5n) is an antitubercular agent with MIC90 values of 0.73, 7.69, 9.38, 18.80, 7.53 and 7.31 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-15 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
    <em>Antitubercular</em> agent-15
  • HY-146557
    Antitubercular agent-16

    		Bacterial Infection
    Antitubercular agent-16 (Compound 5q) is an antitubercular agent with MIC90 values of 0.40, 20.11, 23.51, 19.62, 10.93 and 13.62 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-16 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
    <em>Antitubercular</em> agent-16
  • HY-150554
    Antitubercular agent-29

    		Bacterial Infection
    Antitubercular agent-29 (compound 6xa) is a potent agent resistant (DR) Mycobacterium tuberculosis (Mtb) inhibitor with MIC of 0.03 μg/mL against agent-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains, and favourable selectivity (SI>40) against Vero cells .
    <em>Antitubercular</em> agent-29
  • HY-N12276
    (±)-Emodin bianthrone

    		Parasite Bacterial Fungal Infection
    (±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .
    (±)-Emodin bianthrone
  • HY-156361
    Tuberculosis inhibitor 11

    		Bacterial Infection
    Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .
    Tuberculosis inhibitor 11
  • HY-155332
    AB131

    		Bacterial Infection
    AB131 is a MSMEG 6649 and Rv2172c inhibitor (Kd: 0.16 and 0.02 μM respectively). AB131 can sensitize the antimycobacterial activity of the antitubercular agent .
    AB131
  • HY-N9596
    Stigmasta-4,22-dien-3-one

    		Bacterial Infection Cancer
    Stigmasta-4,22-dien-3-one is an antitubercular agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC50 of 0.3 mM .
    Stigmasta-4,22-dien-3-one
  • HY-19750
    TBA-7371
    1 Publications Verification

    		 Bacterial Infection
    TBA-7371 is a potent, noncovalent DprE1 inhibitor. TBA-7371 has potent antitubercular activity .
    TBA-7371
  • HY-124301
    Penicolinate A

    		Bacterial Infection
    Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .
    Penicolinate A
  • HY-N3661
    (24S)-Cycloartane-3β,24,25-triol

    		Bacterial Infection
    (24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .
    (24S)-Cycloartane-3β,24,25-triol
  • HY-B0271
    Pyrazinamide
    1 Publications Verification

    Pyrazinecarboxamide; Pyrazinoic acid amide

    		 Bacterial Autophagy Antibiotic Infection
    Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
    Pyrazinamide
  • HY-D0190
    2-Thenoyltrifluoroacetone
    1 Publications Verification

    HTTA; TTA; TTFA

    		 Biochemical Assay Reagents Infection Others Cancer
    2-Thenoyltrifluoroacetone is a chelating agent. 2-Thenoyltrifluoroacetone can be used for the complexation of various metal ions including Mn(II), Co(III), Ni(II), et al.. 2-Thenoyltrifluoroacetone possesses antitubercular and cytotoxic activities. 2-Thenoyltrifluoroacetone is also used as common inhibitor of mitochondrial electron flux and to analyze the endothelial cell dysfunction. Besides, copper (II) complex of 2-Thenoyltrifluoroacetone has anticancer activity against K562 .
    2-Thenoyltrifluoroacetone
  • HY-143232
    Antibacterial agent 73

    		Fungal Bacterial Infection Cancer
    Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM .
    Antibacterial agent 73
  • HY-129943
    Benzothiohydrazide

    		Bacterial Infection
    Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2) .
    Benzothiohydrazide
  • HY-119369
    FadD32 Inhibitor-1

    		Bacterial Infection
    FadD32 Inhibitor-1 is a potent FadD32 inhibitor with anti-tubercular activity .
    FadD32 Inhibitor-1
  • HY-N10992
    Pomolic acid 3-acetate

    		Bacterial Infection
    Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H37Rv .
    Pomolic acid 3-acetate
  • HY-W005327
    1-Hydroxy-2-butanone

    		Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice with antitubercular activity .
    1-Hydroxy-2-butanone
  • HY-156421
    QST4

    		Bacterial Infection
    QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv .
    QST4

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: