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Results for "

anti–tubercular

" in MedChemExpress (MCE) Product Catalog:

67

Inhibitors & Agonists

9

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129943
    Benzothiohydrazide

    		Bacterial Infection
    Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2) .
    Benzothiohydrazide
  • HY-146119
    Antitubercular agent-24

    		Bacterial Infection
    Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM against M. tuberculosis H37Rv .
    <em>Antitubercular</em> agent-24
  • HY-146120
    Antitubercular agent-25

    		Bacterial Infection
    Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC50 of 0.42 μM and an intracellular IC50 of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .
    <em>Antitubercular</em> agent-25
  • HY-146121
    Antitubercular agent-26

    		Bacterial Infection
    Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC50 of 0.50 μM and an intracellular IC50 of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .
    <em>Antitubercular</em> agent-26
  • HY-119369
    FadD32 Inhibitor-1

    		Bacterial Infection
    FadD32 Inhibitor-1 is a potent FadD32 inhibitor with anti-tubercular activity .
    FadD32 Inhibitor-1
  • HY-151960
    Antitubercular agent-36

    		Bacterial Infection
    Antitubercular agent-36 (compound 53) is an antitubercular agent. Antitubercular agent-36 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL. Antitubercular agent-36 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-36
  • HY-132928
    Antitubercular agent-10

    		Bacterial Infection
    Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.
    <em>Antitubercular</em> agent-10
  • HY-151958
    Antitubercular agent-35

    		Bacterial Infection
    Antitubercular agent-35 (compound 42l) is an antitubercular agent. Antitubercular agent-35 inhibits the growth of MtbH37Rv and M. Marinum with MIC90 values of 1.25 and 2 μg/mL, respectively. Antitubercular agent-35 shows the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent-35 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-35
  • HY-155190
    Antitubercular agent-39

    		Bacterial Infection
    Antitubercular agent-39 (Compound P1) is a potent antitubercular agent. Antitubercular agent-39 is active against drug-resistant strains and drug-susceptible clinical isolates. Antitubercular agent-39 inhibits Mtb strain H37Rv with a MIC less than 1 μM .
    <em>Antitubercular</em> agent-39
  • HY-163069
    Antitubercular agent-43

    		Bacterial Infection
    Antitubercular agent-43 (compound A11) is an orally active and potent antitubercular agent. Antitubercular agent-43 shows highly metabolic stability against human and mouse cytochrome P450 enzymes. Antitubercular agent-43 exhibits bactericidal efficacy in acute TB infection mouse model .
    <em>Antitubercular</em> agent-43
  • HY-144721
    Antitubercular agent-11

    		Bacterial Infection
    Antitubercular agent-11 (Compound 1e) is an antitubercular agent. Antitubercular agent-11 with a bulkier electron-donating group (Bu-t) demonstrated the best MIC value of 0.060 μg/mL .
    <em>Antitubercular</em> agent-11
  • HY-144722
    Antitubercular agent-12

    		Bacterial Infection
    Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .
    <em>Antitubercular</em> agent-12
  • HY-149857
    Antitubercular agent-37

    		Bacterial Infection
    Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent-37
  • HY-146496
    Antitubercular agent-20

    		Bacterial Infection
    Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .
    <em>Antitubercular</em> agent-20
  • HY-147505
    Antitubercular agent-21

    		Bacterial Fungal Infection
    Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H37Rv. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .
    <em>Antitubercular</em> agent-21
  • HY-132910
    Antitubercular agent-9

    		Bacterial Infection
    Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.
    <em>Antitubercular</em> agent-9
  • HY-156022
    Antitubercular agent-41

    		Bacterial Neurological Disease
    Antitubercular agent-41 (Compound 106) is an antitubercular agent that can be used in the study of Mycobacterium tuberculosis infection .
    <em>Antitubercular</em> agent-41
  • HY-146495
    Antitubercular agent-19

    		Bacterial Infection
    Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .
    <em>Antitubercular</em> agent-19
  • HY-163033
    Antitubercular agent-42

    		Bacterial Infection
    Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC90 = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .
    <em>Antitubercular</em> agent-42
  • HY-146555
    Antitubercular agent-14

    		Bacterial Infection
    Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .
    <em>Antitubercular</em> agent-14
  • HY-151339
    Antitubercular agent-31

    		Bacterial Infection
    Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM .
    <em>Antitubercular</em> agent-31
  • HY-144723
    Antitubercular agent-13

    		Bacterial Infection
    Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 µg/mL and 1.851 µg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability .
    <em>Antitubercular</em> agent-13
  • HY-147884
    Antitubercular agent-28

    		Bacterial Infection
    Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC50 value of 1.5 µM, an MIC value of 4.5 µM, an IC90 value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .
    <em>Antitubercular</em> agent-28
  • HY-147883
    Antitubercular agent-27

    		Bacterial Infection
    Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC50 value of 3.2 µM, an MIC value of 7.8 µM, an IC90 value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .
    <em>Antitubercular</em> agent-27
  • HY-146051
    Antitubercular agent-18

    		Bacterial Infection
    Antitubercular agent-18 (Compound 9a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-18 shows highly selective antimycobacterial effects .
    <em>Antitubercular</em> agent-18
  • HY-146050
    Antitubercular agent-17

    		Bacterial Infection
    Antitubercular agent-17 (Compound 8a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-17 shows highly selective antimycobacterial effects .
    <em>Antitubercular</em> agent-17
  • HY-N0804
    Narirutin
    2 Publications Verification

    		 Bacterial Inflammation/Immunology
    Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .
    Narirutin
  • HY-151957
    Antitubercular agent 34

    		Bacterial Infection
    Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis .
    <em>Antitubercular</em> agent 34
  • HY-151340
    Antitubercular agent-32

    		Bacterial Infection
    Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM) .
    <em>Antitubercular</em> agent-32
  • HY-155067
    Antitubercular agent-38

    		Bacterial Infection
    Antitubercular agent-38 is an orally active Benzothiazinones (BTZs) derivate, with potent antituberculosis activity. Antitubercular agent-38 exhibits low cardiac toxicity, low cell cytotoxicity .
    <em>Antitubercular</em> agent-38
  • HY-162094
    Antitubercular agent-44

    		Bacterial Infection
    Antitubercular agent-44 (compound 21b) has anti-tuberculosis (H37Rv MIC = 0.06 μM). Antitubercular agent-44 has oral activity .
    <em>Antitubercular</em> agent-44
  • HY-146107
    Antitubercular agent-23

    		Bacterial Fungal Infection
    Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
    <em>Antitubercular</em> agent-23
  • HY-146106
    Antitubercular agent-22

    		Bacterial Fungal Infection
    Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .
    <em>Antitubercular</em> agent-22
  • HY-151236
    Antitubercular agent-30

    		Bacterial Infection
    Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). Antitubercular agent-30 has little cytotoxic effect on murine macrophage cells (LD85=~100 μg/mL) .
    <em>Antitubercular</em> agent-30
  • HY-146556
    Antitubercular agent-15

    		Bacterial Infection
    Antitubercular agent-15 (Compound 5n) is an antitubercular agent with MIC90 values of 0.73, 7.69, 9.38, 18.80, 7.53 and 7.31 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-15 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
    <em>Antitubercular</em> agent-15
  • HY-146557
    Antitubercular agent-16

    		Bacterial Infection
    Antitubercular agent-16 (Compound 5q) is an antitubercular agent with MIC90 values of 0.40, 20.11, 23.51, 19.62, 10.93 and 13.62 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-16 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
    <em>Antitubercular</em> agent-16
  • HY-N8388
    Collinin

    		Bacterial Infection
    Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains .
    Collinin
  • HY-147819
    DNA Gyrase-IN-3

    		Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-3 (Compound 28) is a bacterial DNA gyrase B inhibitor with IC50s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity .
    DNA Gyrase-IN-3
  • HY-124781
    ML406

    		Bacterial Antibiotic Infection
    ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .
    ML406
  • HY-148111
    Antitubercular agent-33

    		Bacterial Infection
    Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .
    <em>Antitubercular</em> agent-33
  • HY-147818
    DNA Gyrase-IN-2

    		Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC50s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .
    DNA Gyrase-IN-2
  • HY-150554
    Antitubercular agent-29

    		Bacterial Infection
    Antitubercular agent-29 (compound 6xa) is a potent agent resistant (DR) Mycobacterium tuberculosis (Mtb) inhibitor with MIC of 0.03 μg/mL against agent-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains, and favourable selectivity (SI>40) against Vero cells .
    <em>Antitubercular</em> agent-29
  • HY-149395
    MmpL3-IN-3

    		Bacterial Infection
    MmpL3-IN-3 (Compound 12) is a MmpL3 inhibitor. MmpL3-IN-3 shows a MIC of 0.1 μM against H37Rv. MmpL3-IN-3 shows good stability in mouse liver microsomes. MmpL3-IN-3 can be used for anti-tubercular research .
    MmpL3-IN-3
  • HY-155846
    Antileishmanial agent-22

    		Parasite Bacterial Infection
    Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .
    Antileishmanial agent-22
  • HY-N12276
    (±)-Emodin bianthrone

    		Parasite Bacterial Fungal Infection
    (±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .
    (±)-Emodin bianthrone
  • HY-156361
    Tuberculosis inhibitor 11

    		Bacterial Infection
    Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .
    Tuberculosis inhibitor 11
  • HY-N10992
    Pomolic acid 3-acetate

    		Bacterial Infection
    Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H37Rv .
    Pomolic acid 3-acetate
  • HY-19750
    TBA-7371
    1 Publications Verification

    		 Bacterial Infection
    TBA-7371 is a potent, noncovalent DprE1 inhibitor. TBA-7371 has potent antitubercular activity .
    TBA-7371
  • HY-W005327
    1-Hydroxy-2-butanone

    		Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice with antitubercular activity .
    1-Hydroxy-2-butanone
  • HY-156421
    QST4

    		Bacterial Infection
    QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv .
    QST4

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