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Results for "

anxiety

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (29) Adrenergic Receptor (4) Apoptosis (4) Aryl Hydrocarbon Receptor (1) Autophagy (4) Bacterial (4) Cannabinoid Receptor (1) CRFR (4) Cytochrome P450 (2) Dopamine Receptor (7) Drug Metabolite (1) Endogenous Metabolite (5) FAAH (1) GABA Receptor (14) GHSR (1) Glyoxalase (GLO) (3) GlyT (1) GnRH Receptor (1) Histamine Receptor (5) iGluR (2) Isotope-Labeled Compounds (3) LPL Receptor (2) MCHR1 (GPR24) (3) mGluR (5) Monoamine Oxidase (2) nAChR (4) Neuropeptide Y Receptor (11) Opioid Receptor (4) Orexin Receptor (OX Receptor) (4) Oxytocin Receptor (2) P2X Receptor (1) Potassium Channel (1) Ras (1) Reactive Oxygen Species (2) Serotonin Transporter (6) Sigma Receptor (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (3) Endocrinology (12) Infection (3) Inflammation/Immunology (12) Metabolic Disease (8) Neurological Disease (121)
Click Chemistry:	Azide (1)

144

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-105858

BNC210 H-Ile-Trp-OH; IW-2143	nAChR	Neurological Disease
BNC210 (H-Ile-Trp-OH) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. BNC210 exhibits acute anxiolytic activity in rodent models of anxiety. BNC210 can be used in studies of generalised anxiety disorders .

HY-116780A

Prothipendyl hydrochloride	Others	Neurological Disease
Prothipendyl hydrochloride is an orally active agent that can be used in the study of mental symptoms in the aged (e.g. anxiety) .

HY-B1115

Buspirone hydrochloride 1 Publications Verification	5-HT Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

HY-157392

hMAO-A-IN-1	Monoamine Oxidase	Neurological Disease
hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC₅₀ of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression .

HY-111025

Ectylurea	Others	Neurological Disease
Ectylurea，a N-acylurea，can be used in studies of tension and anxiety symptoms, has no effect on the autonomic nervous system, and has no convulsive, analgesic or antispasmodic activity in animals .

HY-146654

Glyoxalase I inhibitor 2	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety .

HY-146655

Glyoxalase I inhibitor 3	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety .

HY-119677

Oxypertine

Others Neurological Disease

Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia .

Oxypertine	Others	Neurological Disease
Oxypertine is a neuroprotective agent. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia .

HY-145567

Fasedienol PH94B	Others	Neurological Disease
Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety (extracted from patent WO1998014194A1) .

HY-103518

CGP36216	GABA Receptor	Neurological Disease
CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a K_i value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders .

HY-14225

BMS-764459	CRFR Cytochrome P450	Neurological Disease
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer .

HY-A0171A

Benzoctamine hydrochloride Ba-30803	5-HT Receptor	Neurological Disease
Benzoctamine hydrochloride (Ba-30803) is a psychoactive agent with anti-anxiety effect. Benzoctamine hydrochloride blocks the central postsynaptic serotonin receptors and decreases 5-HT turnover in the brain .

HY-N1151

Thunberginol C	Bacterial	Infection Neurological Disease Inflammation/Immunology
Thunberginol C is a natural product that can be isolated from Hydrangea macrophyll. Thunberginol C attenuates stress-induced anxiety. Thunberginol C also has antimicrobial and antiallergic activity .

HY-120686

S-14671	5-HT Receptor	Neurological Disease
S-14671 is a high-affinity 5-HT_1A agonist (pK_i=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc .

HY-103518A

CGP36216 hydrochloride	GABA Receptor	Neurological Disease
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a K_i value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders .

HY-109075A

Tasipimidine sulfate	Adrenergic Receptor	Neurological Disease
Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC₅₀ of 7.57 against human α2A-adrenoceptor. Tasipimidine sulfate can be used for situational anxiety and fear research .

HY-116076

S-15535	5-HT Receptor	Neurological Disease
S-15535 is a highly selective 5-HT_1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT_1A receptors and an agonist of presynaptic 5-HT_1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety .

HY-B0161

Duloxetine (S)-Duloxetine; LY248686	Serotonin Transporter	Neurological Disease
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-116625

PF-04628935	GHSR	Neurological Disease
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC₅₀ of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research .

HY-147306

ZLc-002	Others	Neurological Disease
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation .

HY-B0548

Hydroxyzine	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-B0548A

Hydroxyzine dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-B0161A

Duloxetine hydrochloride 4 Publications Verification (S)-Duloxetine hydrochloride; LY-248686 hydrochloride	Serotonin Transporter	Neurological Disease
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-W028393

Indole-3-pyruvic acid	Endogenous Metabolite Aryl Hydrocarbon Receptor	Neurological Disease Inflammation/Immunology
Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .

HY-14263

Pericyazine Propericiazine; RP 8909	Dopamine Receptor	Neurological Disease
Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis . Pericyazine is a selective D2-dopamine receptor antagonist . Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects .

HY-10886

MCOPPB	Opioid Receptor	Neurological Disease
MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research .

HY-19668A

SGS518 oxalate	5-HT Receptor	Neurological Disease
SGS518 oxalate is a selective 5-HT₆R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses ^[1]

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-107614

1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium	LPL Receptor	Neurological Disease
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression .

HY-B0161AS

Duloxetine D3 hydrochloride (S)-Duloxetine-d₃ (hydrochloride); LY248686-d₃ (hydrochloride)	Serotonin Transporter	Neurological Disease
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-N6057

Obtusin	Monoamine Oxidase	Neurological Disease
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-10066

Nelivaptan SSR-149415	Vasopressin Receptor	Neurological Disease
Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b Receptor antagonist (K_i: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca ²⁺ increase and corticotropin secretion. Nelivaptan can be used for research of stress and anxiety .

HY-118301

ADX71441	GABA Receptor	Neurological Disease
ADX71441 is a potent and selective positive allosteric modulator of the GABA_B receptor. ADX71441 is bioavailable after oral administration and is brain penetrant. ADX71441 has the potential for research of anxiety, pain and spasticity .

HY-162083

CB2R/5-HT1AR agonist 1	Cannabinoid Receptor 5-HT Receptor	Neurological Disease
CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB₂ receptor (EC₅₀=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT_1A receptor (EC₅₀=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties .

HY-110029

Paroxetine maleate BRL29060 maleate	Serotonin Transporter	Neurological Disease
Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research .

HY-118901

Opipramol Ensidon; G-33040	Sigma Receptor	Neurological Disease
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior .

HY-134188

JNJ-54717793	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders .

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior .

HY-137231B

(S)-UFR2709 hydrochloride	nAChR	Neurological Disease
(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α₄β₂ nAChRs than for α₇ nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction .

HY-137231A

(S)-UFR2709	nAChR	Neurological Disease
(S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α₄β₂ nAChRs than for α₇ nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction .

HY-101754

Oxyfenamate

Oxyphenamate; P 301
Others Neurological Disease

Oxyfenamate has anti-anxiety actions for use in anxiety neuroses.

Oxyfenamate Oxyphenamate; P 301	Others	Neurological Disease
Oxyfenamate has anti-anxiety actions for use in anxiety neuroses.

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

HY-122487

Troriluzole BHV-4157	Others	Neurological Disease
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

HY-14380

PF-3845 1 Publications Verification	FAAH Autophagy	Inflammation/Immunology Cancer
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a K_i of 0.23 µM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition .

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior .

HY-107624

ATC0175	MCHR1 (GPR24)	Neurological Disease
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders .

HY-12844

Ro 64-6198 1 Publications Verification	Opioid Receptor	Neurological Disease
Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC₅₀ value of 25.6 nM. Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. Ro 64-6198 can be used for stress and anxiety, addiction, neuropathic pain, cough, and anorexia .

HY-12363

U-69593	Opioid Receptor	Neurological Disease
U-69593 is a potent and selective κ1-opioid receptor agonist . U-69593 attenuates addictive agent-induced behavioral sensitization in the rat . U-69593 reduces anxiety and enhances spontaneous alternation memory in mice . U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum .

HY-B1019

Sulpiride 5 Publications Verification	Dopamine Receptor	Neurological Disease
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P1437

Neuropeptide S(Mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (Mouse) is a bioactive peptide. Neuropeptide S (Mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-P1305

CART(55-102)(rat)	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior .

HY-P2677

CCK (26-31) (sulfated)	Peptides	Metabolic Disease
CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety .

HY-P2678

CCK (26-31) (non-sulfated)	Peptides	Metabolic Disease
CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form .

HY-P1305A

CART(55-102)(rat) TFA	Neuropeptide Y Receptor	Neurological Disease
CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior .

HY-P3692

CART (55-76), rat	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

HY-P3691

CART (1-39), Human, Rat	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior .

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-P1438A

Neuropeptide S(Rat) TFA	Neuropeptide Y Receptor
Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC₅₀=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.

HY-P1437A

Neuropeptide S(Mouse) TFA	Neuropeptide Y Receptor
Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC₅₀=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca ²⁺. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-P1389A

Neuropeptide S (human) (TFA)	Peptides	Neurological Disease
Neuropeptide S human TFA, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human TFA can be used for Alzheimer's disease (AD) research .

HY-P1389

Neuropeptide S (human)	Peptides	Neurological Disease
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	GnRH Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA, a BBB-penatrable neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W028393

Indole-3-pyruvic acid	Structural Classification Alkaloids Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Endogenous Metabolite Aryl Hydrocarbon Receptor
Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety .

HY-N6057

Obtusin	Seeds of Cassia tora Linn. Quinones other families Leguminosae Anthraquinones Source classification Phenols Polyphenols Plants	Monoamine Oxidase
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-N0659

Jujuboside A 2 Publications Verification	Triterpenes Terpenoids Source classification Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Plants Rhamnaceae	GABA Receptor
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, a Chinese herbal medicine used to treat insomnia and anxiety.

HY-B0193

Prazosin Maximum Cited Publications 8 Publications Verification	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-N1151

Thunberginol C	Structural Classification Source classification Hydrangeaceae Coumarins Phenylpropanoids Plants	Bacterial
Thunberginol C is a natural product that can be isolated from Hydrangea macrophyll. Thunberginol C attenuates stress-induced anxiety. Thunberginol C also has antimicrobial and antiallergic activity .

HY-N1363

Royal Jelly acid 2 Publications Verification Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes .

HY-N1363R

Royal Jelly acid (Standard) Queen Bee Acid (Standard); (E)-10-Hydroxy-2-decenoic acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Royal Jelly acid (Standard) is the analytical standard of Royal Jelly acid. This product is intended for research and analytical applications. Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes .

HY-N4097

Incensole	other families Terpenoids Source classification Diterpenoids Plants	Others
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression .

HY-N9241

3-Hydroxy-7-methoxyflavone	Structural Classification Flavonols Flavonoids Labiatae Source classification Gymnaster koraiensis Plants	Others
3-Hydroxy-7-methoxyflavone (compound 1) is a flavonoid. 3-Hydroxy-7-methoxyflavone is isolated from natural Salvia elegans. 3-Hydroxy-7-methoxyflavone has anti-anxiety effect .

HY-N0420

Succinic acid 4 Publications Verification Wormwood acid	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer	Endogenous Metabolite
Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

HY-W015410

Disodium succinate 4 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

Cat. No.	Product Name	Chemical Structure

HY-B0193S

Prazosin-d8
Prazosin-d₈ is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-B0161S

Duloxetine-d7
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B0161AS

Duloxetine D3 hydrochloride
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B1115S

Buspirone-d8 hydrochloride
Buspirone-d₈ (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

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