arthropod

By Targets:	Autophagy (1) Caspase (1) Chloride Channel (1) Endogenous Metabolite (1) GABA Receptor (1) Isotope-Labeled Compounds (1) nAChR (1) Parasite (4)
By Research Areas:	Cardiovascular Disease (2) Infection (5) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115584

Lufenuron	Parasite	Infection
Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .

HY-16974

Afoxolaner	GABA Receptor Chloride Channel Parasite	Infection
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod .

HY-N6979

Crustecdysone 2 Publications Verification 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-145296

Triflumezopyrim	nAChR	Infection
Triflumezopyrim, a mesoionic insecticide, has high efficiency at a low dosage, and is mainly used to control hopper species. Triflumezopyrim mainly acts on the nicotinic acetylcholine receptor (nAChR) inhibition, which is very highly efficient, rapidly effective, and nearly nontoxic to nontarget arthropods .

HY-115584S

Lufenuron-13C6	Isotope-Labeled Compounds Parasite	Infection
Lufenuron- ¹³C₆ is a ¹³C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods[1][2].

HY-116144

Picaridin 2 Publications Verification Lcaridin	Parasite	Infection
Picaridin (Lcaridin) is a broad spectrum arthropod repellent. The repellent and deterrent activities of Picaridin involve olfactory sensing in mosquitoes, and ticks, via their interactions with odorant receptor proteins .

Cat. No.	Product Name

HY-L082

Antiparasitic Compound library	451 compounds
A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs. MCE has a unique collection of 451 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

Antiparasitic Compound library

451 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 451 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

Cat. No.	Product Name	Target	Research Area

HY-P0303

Crustacean cardioactive peptide，free acid	Peptides	Cardiovascular Disease Neurological Disease
Crustacean cardioactive peptide，free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide，free acid also modulates the neuronal activity in other arthropods.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6979

Crustecdysone 2 Publications Verification 20-Hydroxyecdysone	Cardiovascular Disease Structural Classification other families Classification of Application Fields Animals Source classification Plants Compositae Endogenous metabolite Disease Research Fields Canavalia gladiata (Jacq.) DC. Steroids	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-P0303

Crustacean cardioactive peptide，free acid	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Animals Source classification Disease Research Fields	Others
Crustacean cardioactive peptide，free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide，free acid also modulates the neuronal activity in other arthropods.

Cat. No.	Product Name	Chemical Structure

HY-115584S

Lufenuron-13C6
Lufenuron- ¹³C₆ is a ¹³C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods[1][2].

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