asparaginase

By Targets:	Apoptosis (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1)
By Research Areas:	Cancer (2) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108860

Oncaspar PEG-L-asparaginase; Pegasparaginase	Others	Cancer
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) .

HY-P1923

L-Asparaginase 5+ Cited Publications L-ASNase	Apoptosis DNA/RNA Synthesis	Cancer
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .

HY-W010378

D-Asparagine H-D-Asn-OH	Endogenous Metabolite	Metabolic Disease
D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a K_i value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme .

Cat. No.	Product Name

HY-L175

Inflammasomes related Compound Library	67 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 67 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Inflammasomes related Compound Library

67 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 67 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010378

D-Asparagine H-D-Asn-OH	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a K_i value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme .

Cat. No.	Compare	Product Name	Species	Source

HY-P76737

	AGA/Aspartylglucosaminidase Protein, Human (HEK293, His) N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Glycosylasparaginase	Human	HEK293
	The AGA (aspartate glucosaminidase) protein plays a vital role in glycoprotein processing as an enzyme by cleaving the GlcNAc-Asn bond that connects the oligosaccharide to asparagine in the peptide chain of the glycoprotein. connect them. This cleavage represents the specificity of AGA in removing N-linked glycan structures from glycoproteins, a process necessary for the maturation and modification of these proteins. AGA/Aspartylglucosaminidase Protein, Human (HEK293, His) is the recombinant human-derived AGA/Aspartylglucosaminidase protein, expressed by HEK293 , with C-10*His labeled tag. The total length of AGA/Aspartylglucosaminidase Protein, Human (HEK293, His) is 323 a.a., with molecular weight of ~47 & 29 & 23 & 20 kDa, respectively.


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