Search Result

Results for "

atypical

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (29) Adrenergic Receptor (11) Antibiotic (10) Apoptosis (5) Arrestin (1) Autophagy (3) Bacterial (9) Complement System (4) CRFR (1) Cytochrome P450 (1) Dopamine Receptor (33) Dopamine Transporter (2) Drug Metabolite (6) Fluorescent Dye (1) Histamine Receptor (2) Isotope-Labeled Compounds (5) Liposome (1) mAChR (6) Mitophagy (3) Opioid Receptor (3) PKC (3) RAR/RXR (1) ROCK (1) Sigma Receptor (4) TAM Receptor (1) Virus Protease (3)
By Research Areas:	Cancer (12) Endocrinology (1) Infection (16) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (45)

By Targets:

5-HT Receptor (29)

Adrenergic Receptor (11)

Antibiotic (10)

Apoptosis (5)

Arrestin (1)

Autophagy (3)

Bacterial (9)

Complement System (4)

CRFR (1)

Cytochrome P450 (1)

Dopamine Receptor (33)

Dopamine Transporter (2)

Drug Metabolite (6)

Fluorescent Dye (1)

Histamine Receptor (2)

Isotope-Labeled Compounds (5)

Liposome (1)

mAChR (6)

Mitophagy (3)

Opioid Receptor (3)

PKC (3)

RAR/RXR (1)

ROCK (1)

Sigma Receptor (4)

TAM Receptor (1)

Virus Protease (3)

By Research Areas:

Cancer (12)

Endocrinology (1)

Infection (16)

Inflammation/Immunology (8)

Metabolic Disease (3)

Neurological Disease (45)

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136280

Panamesine EMD 57445	Sigma Receptor	Neurological Disease
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC₅₀ 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .

HY-A0019A

Paliperidone palmitate 9-Hydroxyrisperidone palmitate	Dopamine Receptor 5-HT Receptor	Neurological Disease
Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester proagent of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia .

HY-17410

Iloperidone 1 Publications Verification HP 873	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-123813

CCX-777

Arrestin Cancer

CCX-777 is a partial agonist of β-arrestin-2 recruitment to ACKR3 (atypical chemokine receptor 3) .

CCX-777	Arrestin	Cancer
CCX-777 is a partial agonist of β-arrestin-2 recruitment to ACKR3 (atypical chemokine receptor 3) .

HY-123979

ζ-Stat NSC37044	PKC Apoptosis	Cancer
ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC₅₀ of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .

HY-123979A

ζ-Stat trisodium NSC37044 trisodium	PKC Apoptosis	Cancer
ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC₅₀ of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .

HY-163384

(S)-CE-123	Dopamine Transporter	Neurological Disease
(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC₅₀ of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals .

HY-P99365

Ravulizumab ALXN1210	Complement System	Metabolic Disease
Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis .

HY-B0731A

Perospirone SM-9018 free base	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-B0731

Perospirone hydrochloride SM-9018	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT_1A receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-156792

RIOK2-IN-1	Others	Cancer
RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression .

HY-118127

Rilapine

Others Neurological Disease

Rilapine is an atypical antipsychotic agent .
HY-G0002

Lurasidone metabolite 14326

Drug Metabolite Neurological Disease

Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone.

Rilapine	Others	Neurological Disease
Rilapine is an atypical antipsychotic agent .

Lurasidone metabolite 14326	Drug Metabolite	Neurological Disease
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone.

HY-G0002A

Lurasidone metabolite 14326 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.

HY-117083

Clothiapine

5-HT Receptor Neurological Disease

Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .

Clothiapine	5-HT Receptor	Neurological Disease
Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .

HY-G0003

Iloperidone metabolite Hydroxy Iloperidone P88; Hydroxy Iloperidone	Drug Metabolite	Others
Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is a metabolite of Iloperidone, which is an atypical antipsychotic.

HY-131152

Leucinostatin (mixture of A&B)	Antibiotic	Infection Inflammation/Immunology
Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics .

HY-D2201

Fluorescent ACKR3 antagonist 1

Fluorescent Dye Cancer

Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

Fluorescent ACKR3 antagonist 1	Fluorescent Dye	Cancer
Fluorescent ACKR3 antagonist 1(compound 18a) is a atypical chemokine receptor 3 antagonist .

HY-14865C

Omadacycline hydrochloride Maximum Cited Publications 19 Publications Verification PTK0796 hydrochloride; Amadacycline hydrochloride	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-14865

Omadacycline Maximum Cited Publications 19 Publications Verification PTK 0796; Amadacycline	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-14865A

Omadacycline mesylate PTK 0796 mesylate; Amadacycline mesylate	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796) mesylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline mesylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline mesylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline mesylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-14865B

Omadacycline tosylate Maximum Cited Publications 19 Publications Verification PTK 0796 tosylate; Amadacycline tosylate	Bacterial Antibiotic	Infection
Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline tosylate acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections .

HY-B1059

Levosulpiride RV-12309; S-(-)-Sulpiride	Dopamine Receptor	Neurological Disease
Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

HY-17410A

Iloperidone hydrochloride HP 873 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone hydrochloride (HP 873 hydrochloride) is a D₂/5-HT₂ receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms .

HY-121301

Amperozide	5-HT Receptor	Neurological Disease
Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a K_i value of 26 nM. Amperozide has a low affinity for D2 receptors .

HY-163138

DAT-IN-1	Dopamine Transporter	Neurological Disease
DAT-IN-1 (Coumpound 12b) is an atypical DAT inhibitor with a K_i of 8.37 nM. DAT-IN-1 can be used in the study of psychostimulant use disorder (PSUD) .

HY-101106

AR7 5 Publications Verification	RAR/RXR	Neurological Disease Cancer
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .

HY-13575S

Blonanserin-d8 AD-5423 d₈	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-13575S1

Blonanserin-d5 AD-5423-d₅	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-B1059S

Levosulpiride-d3 RV-12309-d₃; S-(-)-Sulpiride-d₃	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Levosulpiride-d₃ is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].

HY-B1386

Halazone
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

HY-18713A

CRT0066854 hydrochloride	PKC ROCK	Neurological Disease
CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-14225

BMS-764459	CRFR Cytochrome P450	Neurological Disease
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer .

HY-17410S

Iloperidone-d3	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].

HY-18713

CRT0066854
CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-B1019

Sulpiride 5 Publications Verification	Dopamine Receptor	Neurological Disease
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

HY-118901

Opipramol Ensidon; G-33040	Sigma Receptor	Neurological Disease
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-116874

SKF 83822	Dopamine Receptor	Neurological Disease
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia .

HY-B0395C

Sitafloxacin hydrate 4 Publications Verification DU6859a hydrate	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .

HY-B1196A

Tiapride
Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. The IC₅₀ values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively .

HY-13575A

Blonanserin dihydrochloride AD-5423 dihydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin dihydrochloride is a potent and orally active 5-HT_2A and dopamine D2 receptor antagonist, with K_i values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-10121

Asenapine 1 Publications Verification Org 5222	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-10121B

Asenapine citrate Org 5222 citrate	5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor	Neurological Disease
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder .

HY-13575

Blonanserin AD-5423	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin (AD-5423) is a potent and orally active 5-HT_2A (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-B0395

Sitafloxacin DU6859a	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

HY-B0395B

Sitafloxacin monohydrate DU6859a monohydrate	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tract infection and urinary tract infection .

HY-B0395A

Sitafloxacin hydrochloride DU6859a hydrochloride	Antibiotic Bacterial	Infection
Sitafloxacin (DU6859a) hydrochloride is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin hydrochloride shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin hydrochloride can be used for the research of respiratory tract infection and urinary tract infection .

HY-B1019R

Sulpiride (Standard)	Dopamine Receptor	Neurological Disease
Sulpiride (Standard) is the analytical standard of Sulpiride. This product is intended for research and analytical applications. Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

HY-122054

BPK-29	Others	Cancer
BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells .

HY-122054A

BPK-29 hydrochloride	Others	Cancer
BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0019

Paliperidone 1 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-131152

Leucinostatin (mixture of A&B)	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic
Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics .

Species:	Human (4)
Tag:	SUMO (1) His (3) GST (1)
Source:	E. coli Cell-free (3) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702645

	PRKCI Protein, Human (sf9, GST) PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI; PRKC-lambda/iota; aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; MGC26534	Human	Sf9 insect cells

HY-P702198

	ACKR3 Protein, Human (Cell-Free, His, SUMO) atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1	Human	E. coli Cell-free
	ACKR3 is an atypical chemokine receptor that precisely controls chemokine levels and localization through high-affinity binding, operating independently of ligand-driven signaling. It acts as an interceptor, internalization receptor, and chemokine scavenger for CXCL11 and CXCL12/SDF1, inducing β-arrestin recruitment, ligand internalization, and MAPK pathway activation. ACKR3 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ACKR3 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ACKR3 Protein, Human (Cell-Free, His, SUMO) is 362 a.a., with molecular weight of 57.5 kDa.

HY-P700380

	ACKR1 Protein, Human (Cell-Free, His) ACKR1; atypical chemokine receptor 1 (Duffy blood group); DARC; Duffy blood group, chemokine receptor; Duffy blood group , FY; Duffy antigen/chemokine receptor; CCBP1; CD234; Dfy; GPD; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; FY; GpFy; WBCQ1	Human	E. coli Cell-free
	ACKR3, an atypical chemokine receptor, modulates chemokine levels and localization by high-affinity binding, inducing sequestration, degradation, or transcytosis. Also known as a chemokine interceptor or decoy receptor, ACKR3 binds to chemokines like CXCL11 and CXCL12/SDF1. Unlike conventional signaling, ACKR3 triggers beta-arrestin recruitment, leading to ligand internalization and MAPK pathway activation. In interneurons, it regulates CXCR4 levels, adapting chemokine responsiveness. In glioma cells, it activates the MEK/ERK pathway, influencing growth and survival. While inactive in normal hematopoietic cells, ACKR3, activated by CXCL11 in malignant cells, enhances cell adhesion, migration, and acts as an HIV coreceptor. ACKR1 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR1 Protein, Human (Cell-Free, His) is 336 a.a., with molecular weight of 41.1 kDa.

HY-P700378

	ACKR2 Protein, Human (Cell-Free, His) ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250	Human	E. coli Cell-free
	ACKR2 Protein, an atypical chemokine receptor, controls chemokine levels and localization with high-affinity binding. Operating independently, ACKR2, also known as an interceptor or decoy receptor, interacts with diverse chemokines, triggering a beta-arrestin 1-dependent signaling pathway. This pathway facilitates ACKR2 relocation, enhancing efficiency in chemokine uptake and degradation. Scavenging chemokines in various tissues, ACKR2 plays a pivotal role in resolving inflammation, regulating adaptive immune responses, and influencing leukocyte interactions with lymphatic endothelial cells. ACKR2 contributes significantly to immune silencing of macrophages during inflammation resolution. ACKR2 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR2 Protein, Human (Cell-Free, His) is 384 a.a., with molecular weight of 46.9 kDa.

Cat. No.	Product Name	Chemical Structure

HY-13575S1

Blonanserin-d5

Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-B1059S

Levosulpiride-d3
Levosulpiride-d₃ is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].

HY-13575S

Blonanserin-d8

Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-17410S

Iloperidone-d3
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-14541S

Olanzapine-d3
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

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