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Results for "

bisphosphonates

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (12) Autophagy (3) Bacterial (7) Fluorescent Dye (1) Isotope-Labeled Compounds (4) P2X Receptor (2) Parasite (2) Proton Pump (3) Ras (1)
By Research Areas:	Cancer (22) Infection (4) Inflammation/Immunology (4) Metabolic Disease (8) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150167

TH-Z93

Bacterial Infection

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 90 nM) .
HY-150168

TH-Z145

Bacterial Infection

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 210 nM) .

TH-Z93	Bacterial	Infection
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 90 nM) .

TH-Z145	Bacterial	Infection
TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 210 nM) .

HY-13777

Zoledronic Acid Maximum Cited Publications 8 Publications Verification Zoledronate; CGP 42446; CGP42446A; ZOL 446	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-13777A

Zoledronic acid monohydrate Maximum Cited Publications 8 Publications Verification Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects .

HY-108685

Alendronate sodium Alendronic acid monosodium salt	Others	Metabolic Disease
Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis .

HY-B0631

Alendronic acid 2 Publications Verification	Others	Cancer
Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease .

HY-A0213A

Tiludronate disodium Tiludronic acid disodium	Proton Pump	Inflammation/Immunology
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-A0213B

Tiludronate disodium hemihydrate Tiludronic acid disodium hemihydrate	Proton Pump	Metabolic Disease
Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H ⁺-ATPase. Antiresorptive and anti-inflammatory properties .

HY-13777B

Zoledronic acid disodium tetrahydrate Zoledronate disodium tetrahydrate; CGP 42446 disodium tetrahydrate; CGP42446A disodium tetrahydrate; ZOL 446 disodium tetrahydrate	Apoptosis Autophagy Bacterial	Metabolic Disease Cancer
Zoledronic Acid (Zoledronate) disodium tetrahydrate is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid disodium tetrahydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid disodium tetrahydrate also has anti-cancer effects .

HY-119001

BKM1644	Others	Cancer
BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance .

HY-B0012A

Pamidronate Disodium

CGP 23339A
Bacterial Metabolic Disease Cancer

Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.

Pamidronate Disodium CGP 23339A	Bacterial	Metabolic Disease Cancer
Pamidronate disodium, a bisphosphonate drug, can help to strengthen bones.

HY-B0515

Ibandronate Sodium Monohydrate BM-210955; RPR-102289A	Apoptosis	Cancer
Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-B0515A

Ibandronic acid

Others Cancer

Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
HY-B0515B

Ibandronate Sodium

Others Metabolic Disease

Ibandronate Sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
HY-B0730

Pamidronate disodium pentahydrate

Bacterial Cancer

Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.

Ibandronic acid	Others	Cancer
Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

Ibandronate Sodium	Others	Metabolic Disease
Ibandronate Sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

Pamidronate disodium pentahydrate	Bacterial	Cancer
Pamidronate disodium pentahydrate is a nitrogen-containing bisphosphonate, used to prevent osteoporosis.

HY-U00145

Digeranyl bisphosphonate 1 Publications Verification DGBP	Ras	Inflammation/Immunology
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.

HY-D2133

Cy5-ALN

Alendronate-Cy5
Fluorescent Dye Others

Cy5-ALN (Alendronate-Cy5) is a fluorescently labeled bisphosphonate probe .

Cy5-ALN Alendronate-Cy5	Fluorescent Dye	Others
Cy5-ALN (Alendronate-Cy5) is a fluorescently labeled bisphosphonate probe .

HY-16011

NE 10790 1 Publications Verification 3-PEHPC	Others	Others
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

HY-B0515AS1

Ibandronic acid-d3	Apoptosis Isotope-Labeled Compounds	Cancer
Ibandronic acid-d₃ is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-118224

BPH-715

Parasite Infection

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

BPH-715	Parasite	Infection
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

HY-B0515AS

Ibandronic Acid-d3 sodium salt	Apoptosis Isotope-Labeled Compounds	Cancer
Ibandronic Acid-d₃ (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].

HY-113752

MMV019313	Parasite	Infection
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC₅₀ of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .

HY-107093

MBC-11	Others	Cancer
MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 has the potential for tumor-induced bone disease (TIBD) research .

HY-107093A

MBC-11 trisodium	Others	Cancer
MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. MBC-11 trisodium has the potential for tumor-induced bone disease (TIBD) research .

HY-B0657A

Clodronic acid disodium salt Clodronate disodium salt
Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget ^’s disease and osteolytic bone metastases .

HY-107093B

MBC-11 triethylamine	Others	Cancer
MBC-11 triethylamine is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). MBC-11 triethylamine has the potential for tumor-induced bone disease (TIBD) research .

HY-A0213

Tiludronate Tiludronic acid
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties .

HY-B0657

Clodronic acid Clodronate	Others	Others
Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density .

HY-B0631S

Alendronic acid-d6	Isotope-Labeled Compounds	Cancer
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

HY-B0302

Etidronic acid 1 Publications Verification Etidronate; HEDPA; HEDP	Apoptosis	Metabolic Disease Cancer
Etidronic acid (Etidronate) is an orally and intravenously active bisphosphonate. Etidronic acid inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid has anticancer activity. Etidronic acid is a chelating agent and can be used to remove heavy metal in water .

HY-108309

Medronic acid Methylenediphosphonic acid	Others	Others
Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. Medronic acid can be used in bone imaging, while being complexed with radioisotopes. Due to its strong metal-chelating ability, Medronic acid can also be used as a water treatment chemical .

HY-16322

Minodronic acid YM-529	P2X Receptor Apoptosis	Cancer
Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain .

HY-B0302A

Etidronic acid disodium 1 Publications Verification Etidronate disodium; HEDPA disodium; HEDP disodium
Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water .

HY-A0213AS

Tiludronate-d5 sodium Tiludronic acid-d₅ (sodium)	Proton Pump	Inflammation/Immunology
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

HY-107794

Clodronate disodium tetrahydrate Disodium clodronate tetrahydrate	Others	Neurological Disease Inflammation/Immunology Cancer
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl ^- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC₅₀ of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain .

HY-144129

hGGPPS-IN-2	Apoptosis	Cancer
hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .

HY-144130

hGGPPS-IN-3	Apoptosis	Cancer
hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .

HY-144128

hGGPPS-IN-1	Apoptosis	Cancer
hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .

HY-16322S

Minodronic acid-d4 YM-529-d₄	Isotope-Labeled Compounds P2X Receptor Apoptosis	Cancer
Minodronic acid-d₄ is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].

Cy5-ALN Alendronate-Cy5	Fluorescent Dyes/Probes
Cy5-ALN (Alendronate-Cy5) is a fluorescently labeled bisphosphonate probe .

Alendronic acid-d6
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

Ibandronic acid-d3
Ibandronic acid-d₃ is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

Ibandronic Acid-d3 sodium salt
Ibandronic Acid-d₃ (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].

Tiludronate-d5 sodium
Tiludronate-d₅ (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

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