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Results for "

bitter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (3) Biochemical Assay Reagents (1) Endogenous Metabolite (1) P-glycoprotein (1) Parasite (2) Taste Receptor (2)
By Research Areas:	Cancer (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121376

Neoamygdalin	Others	Inflammation/Immunology
Neoamygdalin is a compound identified in the different processed bitter almonds. Neoamygdalin has the potential for the research of cough and asthma .

HY-W009141

1-Monopalmitin

Glyceryl palmitate
P-glycoprotein Cancer

1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .
HY-120735

Lascivol

Others Others

Lascivol is a bitter compound isolated from Tricholoma species .
HY-121691

Sugereoside

Others Others

Sugereoside is a bitter diterpene glucoside. Sugereoside can be isolated from leaves of Ilex sugerokii var .
HY-N12718

Campneoside I

Others Others

Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

1-Monopalmitin Glyceryl palmitate	P-glycoprotein	Cancer
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

Lascivol	Others	Others
Lascivol is a bitter compound isolated from Tricholoma species .

Sugereoside	Others	Others
Sugereoside is a bitter diterpene glucoside. Sugereoside can be isolated from leaves of Ilex sugerokii var .

Campneoside I	Others	Others
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

HY-119309

Sucrose octaacetate	Biochemical Assay Reagents	Others
Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .

HY-N7261

Charantin	Others	Metabolic Disease
Charantin is a hypoglycemic agent isolated from bitter melon. The antidiabetic activity of bitter melon is attributed to different mechanisms, including increased pancreatic insulin secretion, reduced insulin resistance, increased peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption, and inhibition of key enzymes in the gluconeogenic pathway .

HY-124956

GIV3727	Taste Receptor	Others
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .

HY-B1146

Denatonium benzoate THS-839	Others	Others
Denatonium benzoate (THS-839) is the most bitter compound known, commonly used as an aversion agent (bitter agent) to prevent inappropriate ingestion, used in denatured alcohol, antifreeze, nail biting prevention, respirator mask fit testing , animal repellents, liquid soaps and shampoos.

HY-100047

Nα,Nα-Bis(carboxymethyl)-L-lysine
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC₅₀ of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

HY-N3944

Glaucin B

6β-Acetoxy-5-epilimonin
Others Others

Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

Glaucin B 6β-Acetoxy-5-epilimonin	Others	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

HY-N0742

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

HY-N8290

Lactupicrin Lactucopicrin	Others	Neurological Disease Metabolic Disease
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-N10867

β-Acids colupulone

Others Others

β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .
HY-111070

Karavilagenin D

Others Cancer

Karavilagenin D, a cucurbitane-type triterpene isolated from Japanese bitter melon leaves, is a potential tumor-promoting inhibitor .

β-Acids colupulone	Others	Others
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

Karavilagenin D	Others	Cancer
Karavilagenin D, a cucurbitane-type triterpene isolated from Japanese bitter melon leaves, is a potential tumor-promoting inhibitor .

HY-123026

Salannin	Bacterial	Infection
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

HY-N11975

Glycyrrhizin-6′,6′′-dimethylester	Others	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

HY-124257

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Endogenous Metabolite	Inflammation/Immunology
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification (R)-(-)-Mandelic acid
D-(-)-Mandelic acid is the isomer of Mandelic acid (HY-W015591). Mandelic acid is an orally active α hydroxycarboxylic acid that can be isolated from bitter almonds and Aesculus indica. Mandelic acid has anti-oxidant and anti-inflammatory activities. Mandelic acid reduces the liberation of auto-antigens, oxygen free radicals and proinflammatory mediators resulting in inhibition of protein denaturation, which is favorable in dismissing the pain related with arthritis .

HY-136352

Adenosine 5'-succinate	Taste Receptor	Others
Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin .

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-136429A

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-153264

TAS2R14 agonist-1

Others Others

TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

TAS2R14 agonist-1	Others	Others
TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

Neoamygdalin	Alkaloids Classification of Application Fields Source classification Rosaceae Plants Prunus armeniaca L. Disease Research Fields Inflammation/Immunology Food Research	Others
Neoamygdalin is a compound identified in the different processed bitter almonds. Neoamygdalin has the potential for the research of cough and asthma .

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

Lascivol	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Others
Lascivol is a bitter compound isolated from Tricholoma species .

Sugereoside	Structural Classification Terpenoids Source classification Diterpenoids Plants Compositae Achillea clypeolata Sm.	Others
Sugereoside is a bitter diterpene glucoside. Sugereoside can be isolated from leaves of Ilex sugerokii var .

Campneoside I	Structural Classification Source classification Phenols Polyphenols Bignoniaceae Plants Incarvillea compacta Maxim.	Others
Campneoside I is a bitter phenyl propanoid glycoside. Campneoside I can be isolated from the roots of Incarvillea compacta .

Charantin	Structural Classification Classification of Application Fields Source classification Cucurbitaceae Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Momordica charantia Linn.	Others
Charantin is a hypoglycemic agent isolated from bitter melon. The antidiabetic activity of bitter melon is attributed to different mechanisms, including increased pancreatic insulin secretion, reduced insulin resistance, increased peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption, and inhibition of key enzymes in the gluconeogenic pathway .

Glaucin B 6β-Acetoxy-5-epilimonin	Triterpenes Structural Classification Terpenoids Source classification Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

Absinthin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Acacia confusa Merr. Compositae Disease Research Fields	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Lactupicrin Lactucopicrin	Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	Others
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

β-Acids colupulone	Structural Classification Natural Products Humulus lupulus L. Source classification Plants Moraceae	Others
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

Karavilagenin D	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Others
Karavilagenin D, a cucurbitane-type triterpene isolated from Japanese bitter melon leaves, is a potential tumor-promoting inhibitor .

Salannin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	Bacterial
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

Glycyrrhizin-6′,6′′-dimethylester	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Umbelliferae	Others
Glycyrrhizin-6′,6′′-dimethylester (compound 23) is a licorice saponin isolated from licorice root. Glycyrrhizin-6′,6′′-dimethylester can participate as an aglycone in the generation of methyl glucuronate, producing similar threshold sweetness, licorice, and bitterness .

(R)-Citronellol D-Citronellol; (R)-(+)-β-Citronellol	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Pelargonium hortorum Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Geraniaceae	Endogenous Metabolite
(R)-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. (R)-Citronellol inhibits degranulation of mast cells and does not affect caffeine bitterness perception. (R)-Citronellol can be used in decorative cosmetics, toiletries as well as in non-cosmetic products .

Glycyrrhizin-6′′-methylester	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Ketones, Aldehydes, Acids Source classification Plants	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

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bitter

Inhibitors & Agonists

NaturalProducts

Natural
Products