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brain+disorders

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By Targets:	5-HT Receptor (1) Cannabinoid Receptor (1) Ferroptosis (1) Fluorescent Dye (1) Glutathione Peroxidase (1) HCN Channel (1) iGluR (1)
By Research Areas:	Cardiovascular Disease (1) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17646

Verdiperstat 5+ Cited Publications AZD3241	Glutathione Peroxidase	Neurological Disease
Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC₅₀ of 630 nM, and can be used in the research of neurodegenerative brain disorders.

HY-160505

RO-275	HCN Channel	Neurological Disease
RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC₅₀ values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder .

HY-148137

CB1 agonist 1 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC₅₀ value of 5.7. CB1 agonist 1 can be used for the research of brain disorders .

HY-112095

EVT-101 free base ENS-101 free base	iGluR	Neurological Disease
EVT-101 free base is a GluN₂B antagonist. EVT-101 free base binds at the same GluN₁/GluN₂B dimer interface as Ifenprodil (HY-12882). EVT-101 free base inhibits calcium influx in chicken-derived cells, with an EC₅₀ of 22 nM. EVT-101 can be used in the research of brain disorders .

HY-176216

5-HT2C agonist-5	5-HT Receptor	Neurological Disease
5-HT2C agonist-5 (Compound 3A) is a 5-HT2C agonist (EC₅₀: <1 nM). 5-HT2C agonist-5 can be used for research of brain disorders .

HY-185056

Ferfluor-1	Ferroptosis Fluorescent Dye	Cardiovascular Disease Neurological Disease
Ferfluor-1 is a Ferroptosis inhibitor (EC₅₀ of 57 nM in HT108 cells; EC₅₀ of 75 nM in OS-RC-2 cells; EC₅₀ of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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brain+disorders

Inhibitors & Agonists