Search Result

Results for "

c-kit

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Kit (53) Akt (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (20) Aurora Kinase (1) Autophagy (18) Bcr-Abl (11) c-Fms (12) c-Met/HGFR (5) Casein Kinase (1) CDK (1) Checkpoint Kinase (Chk) (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (2) EGFR (3) FAK (1) Ferroptosis (3) FGFR (12) FLT3 (17) IKK (1) Isotope-Labeled Compounds (4) NAMPT (2) NO Synthase (1) PDGFR (39) PDK-1 (1) Pim (1) PKA (1) PKC (2) RAD51 (2) Raf (3) RET (4) SARS-CoV (4) Src (5) Syk (1) Trk Receptor (1) VEGFR (26)
By Research Areas:	Cancer (66) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (6)

By Targets:

c-Kit (53)

Akt (2)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (20)

Aurora Kinase (1)

Autophagy (18)

Bcr-Abl (11)

c-Fms (12)

c-Met/HGFR (5)

Casein Kinase (1)

CDK (1)

Checkpoint Kinase (Chk) (1)

Drug Metabolite (3)

Drug-Linker Conjugates for ADC (2)

EGFR (3)

FAK (1)

Ferroptosis (3)

FGFR (12)

FLT3 (17)

IKK (1)

Isotope-Labeled Compounds (4)

NAMPT (2)

NO Synthase (1)

PDGFR (39)

PDK-1 (1)

Pim (1)

PKA (1)

PKC (2)

RAD51 (2)

Raf (3)

RET (4)

SARS-CoV (4)

Src (5)

Syk (1)

Trk Receptor (1)

VEGFR (26)

By Research Areas:

Cancer (66)

Cardiovascular Disease (2)

Infection (1)

Inflammation/Immunology (6)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

c-Kit-IN-5-1	c-Kit	Inflammation/Immunology
c-Kit-IN-5 is potent inhibitor of *c-Kit, with IC₅₀s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit* over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .

c-Kit-IN-1	c-Kit c-Met/HGFR	Cancer
c-Kit-IN-1 is a potent inhibitor of *c-Kit* and c-Met with IC₅₀s of <200 nM.

M4205	c-Kit	Cancer
M4205 is a *c-KIT* inhibitor, with an IC₅₀ of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

N-Desmethyl imatinib Norimatinib; Imatinib metabolite N-Desmethyl imatinib	Drug Metabolite	Others
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

c-Kit-IN-2	c-Kit	Cancer
c-Kit-IN-2 is a *c-KIT* inhibitor with an IC₅₀ of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI₅₀s of 3, 1, and 2 nM, respectively .

N-Desmethyl imatinib mesylate Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate	Drug Metabolite	Others
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

Labuxtinib	c-Kit	Cancer
Labuxtinib is c-kit tyrosine kinase inhibitor .

Flumatinib mesylate HHGV678 mesylate	Bcr-Abl c-Kit PDGFR	Cancer
Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC₅₀ values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model .

KBP-7018	c-Kit RET PDGFR	Infection
KBP-7018 is a tyrosine kinase-selective inhibitor. KBP-7018 has potent inhibitory effects on c-KIT, PDGFR, and RET with IC₅₀ values of 10 nM, 7.6 nM and 25 nM, respectively. KBP-7018 can be used for the research of idiopathic pulmonary fibrosis .

Vatalanib succinate PTK787 succinate; ZK-222584 succinate; CGP-79787 succinate	VEGFR	Cancer
Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC₅₀s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively .

ISCK03 2 Publications Verification	c-Kit	Inflammation/Immunology
ISCK03 is a *SCF/c-Kit* and CD117-specific inhibitor. ISCK03 significantly inhibits c-Kit phosphorylation at 10 μM .

Henatinib	VEGFR c-Kit PDGFR	Cancer
Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, *c-kit, PDGFR* with IC₅₀ values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs) .

Chiauranib Ibcasertib; CS2164	VEGFR PDGFR c-Kit Aurora Kinase c-Fms	Cancer
Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and *c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC₅₀* values ranging from 1-9 nM. Chiauranib has strongly anticancer effects .

Imatinib Mesylate 65+ Cited Publications STI571 Mesylate; CGP-57148B Mesylate	c-Kit Bcr-Abl PDGFR Autophagy	Cancer
Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits *c-Kit, Bcr-Abl, and PDGFR* (IC₅₀=100 nM) tyrosine kinases.

Tyrphostin AG1296 1 Publications Verification AG1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

Pexidartinib hydrochloride 65+ Cited Publications PLX-3397 hydrochloride	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and *c-Kit* inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .

Masitinib 5 Publications Verification AB1010	c-Kit PDGFR Src FGFR FAK Apoptosis	Cancer
Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of *c-Kit* (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity .

Masitinib mesylate 5 Publications Verification AB-1010 mesylate	c-Kit PDGFR Src FGFR Apoptosis	Cancer
Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of *c-Kit* (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity .

CHMFL-KIT-033	c-Kit	Cancer
CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC₅₀ of 0.045 μM .

AZD3229	c-Kit	Cancer
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

Pexidartinib 65+ Cited Publications PLX-3397	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and *c-Kit* inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .

Telatinib 1 Publications Verification Bay 57-9352	c-Kit PDGFR VEGFR	Cancer
Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR2, VEGFR3, PDGFα, and *c-Kit* with IC₅₀s of 6, 4, 15 and 1 nM, respectively.

Telatinib mesylate 1 Publications Verification Bay 57-9352 mesylate	VEGFR PDGFR c-Kit	Cancer
Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and *c-Kit* inhibitor with IC₅₀s of 6 nM, 4 nM, 15 nM and 1 nM, respectively .

Risvodetinib IkT-148009	c-Met/HGFR	Cancer
Risvodetinib is a potent protein tyrosine kinase inhibitor. Risvodetinib involves in synthesis of Abelson protein kinases (c-Abl1, c-Abl2, and c-kit) inhibitor .

AZD2932	PDGFR VEGFR FLT3 c-Kit	Cancer
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3 and *c-Kit* with IC₅₀s of 8, 4, 7 and 9 nM in cell assay, respectively.

Flumatinib HHGV678	Bcr-Abl c-Kit PDGFR	Cancer
Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and *c-Kit* with IC₅₀s of 1.2 nM, 307.6 nM and 665.5 nM, respectively .

c-Fms-IN-6	c-Fms	Inflammation/Immunology
c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC₅₀ of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC₅₀, > 1 μM). Used in the research of autoimmune diseases .

Imatinib Mesylate (Standard) STI571 Mesylate (Standard); CGP-57148B Mesylate (Standard)	c-Kit Bcr-Abl PDGFR Autophagy	Cancer
Imatinib (Mesylate) (Standard) is the analytical standard of Imatinib (Mesylate). This product is intended for research and analytical applications. Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits *c-Kit, Bcr-Abl, and PDGFR* (IC₅₀=100 nM) tyrosine kinases.

NAMPT inhibitor-linker 2	NAMPT Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC₅₀s of <7 pM and 40 pM, respectively.

Multi-kinase-IN-6	Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis	Cancer
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, *c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC₅₀* values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect .

Pazopanib Hydrochloride 10+ Cited Publications GW786034 Hydrochloride	PDGFR VEGFR FGFR c-Kit c-Fms Autophagy	Cancer
Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, *c-Kit, FGFR1, and c-Fms* with an IC₅₀ of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

Cediranib maleate 5+ Cited Publications AZD-2171 maleate	VEGFR Autophagy PDGFR	Cancer
Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC₅₀s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

NAMPT inhibitor-linker 1	Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC₅₀s of <3 pM and 9 pM, respectively.

Cediranib 5+ Cited Publications AZD2171	VEGFR Autophagy PDGFR	Cancer
Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC₅₀s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.

Pazopanib 10+ Cited Publications GW786034	VEGFR c-Kit PDGFR Autophagy FGFR	Cancer
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, *c-Kit, FGFR1, and c-Fms* with IC₅₀s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

Multi-kinase inhibitor 1	PDGFR c-Kit Bcr-Abl	Cancer
Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, *c-Kit* and Bcr-abl .

Seralutinib 1 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

VEGFR-IN-1
VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC₅₀s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively .

Vimseltinib DCC-3014	c-Fms c-Kit	Cancer
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and *c-Kit* dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC₅₀s of <0.01 μM and 0.1-1 μM, respectively .

Apatinib-d8 free base YN968D1-d₈ free base	Src VEGFR Autophagy c-Kit RET	Cancer
Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4].

Dovitinib lactate 5+ Cited Publications CHIR-258 lactate; TKI-258 lactate	FLT3 c-Kit FGFR VEGFR PDGFR	Cancer
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, *c-Kit, FGFR1/3, VEGFR1/2/3* and PDGFRα/β, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Cat. No.	Product Name	Target	Research Area

HY-P99488

Briquilimab JSP-191	Inhibitory Antibodies	Inflammation/Immunology
Briquilimab (JSP-191) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID) .

HY-P990020

Eglatoprutug

Inhibitory Antibodies Others

Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody .

Species:	Human (10) Rhesus Macaque (1) Mouse (3) Rat (3)
Tag:	His (10) Tag Free (1) GST (2) Flag (1) Fc (5)
Source:	HEK293 (11) Sf9 insect cells (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P78712

	*CD117/c-kit* Protein, Mouse (495a.a, HEK293, Fc)** CD117; SCFR; c-kit; kit	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is the recombinant mouse-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is 495 a.a., with molecular weight of ~110 kDa.

HY-P72480

	SCF Protein, Rat (His) kit ligand; MGF; SCF; c-kit ligand; skitLG; kitlg	Rat	E. coli
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (His) is the recombinant rat-derived SCF protein, expressed by E. coli , with C-6*His labeled tag. The total length of SCF Protein, Rat (His) is 164 a.a., with molecular weight of ~17 kDa.

HY-P702691

	*CD117/c-kit* Protein, Human (P10721-1, sf9)** kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor kit; C kit; CD117; SCFR; p145 c-kit; proto-oncogene c-kit; piebald trait protein; soluble kit variant 1; tyrosine-protein kinase kit; proto-oncogene tyrosine-protein kinase kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-kit	Human	Sf9 insect cells

HY-P70757G

	GMP SCF Protein, Human (HEK293, His) kit Ligand; MGF; SCF; c-kit ligand; kitLG; skitLG	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. GMP SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight of 30-50 kDa.

HY-P70781

	SCF Protein, Human 3 Publications Verification kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-kit ligand; kitLG; MGF; SCF	Human	E. coli
	SCF, Human, as a recombinant protein, plays essential roles in gametogenesis, melanogenesis and hematopoiesis. SCF, Human also plays an important role in nervous system.

HY-P70757

	SCF Protein, Human (HEK293, His) kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-kit ligand; kitLG; MGF; SCF	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight (glycosylation form) of 30-50 kDa.

HY-P700148AF

	Animal-Free SCF Protein, Human (His) kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-kit ligand; kitLG; MGF; SCF	Human	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. Animal-Free SCF Protein, Human (His) is the recombinant human-derived animal-FreeSCF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free SCF Protein, Human (His) is 164 a.a., with molecular weight of ~19.4 kDa.

HY-P72752

	*CD117/c-kit* Protein, Human (HEK293, His)** Mast/stem cell growth factor receptor kit; SCFR; PBT; CD117; kit	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD117/c-kit Protein, Human (HEK293, His) is 495 a.a., with molecular weight of ~150 kDa.

HY-P72880

	*CD117/c-Kit* Protein, Mouse (HEK293, His)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD117/c-Kit Protein, Mouse (HEK293, His) is 499 a.a., with molecular weight of 70-80 kDa.

HY-P74337

CD117/c-kit Protein, Rat (HEK293, His)

Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl
Rat HEK293
HY-P74338

CD117/c-kit Protein, Rat (HEK293, Fc)

Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl
Rat HEK293

HY-P74336

	*CD117/c-kit* Protein, Rhesus Macaque (HEK293, Fc)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Rhesus Macaque	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is 495 a.a., with molecular weight of 100-130 kDa.

HY-P74341

	*CD117/c-kit* Protein, Human (141a.a, His)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Human	E. coli
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (141a.a, His) is the recombinant human-derived CD117/c-kit protein, expressed by E. coli , with N-His labeled tag. The total length of CD117/c-kit Protein, Human (141a.a, His) is 141 a.a., with molecular weight of ~18 kDa.

HY-P72879

	*CD117/c-Kit* Protein, Mouse (523a.a, HEK293, Fc)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (523a.a, HEK293, Fc) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-Kit Protein, Mouse (523a.a, HEK293, Fc) is 499 a.a., with molecular weight of 100-120 kDa.

HY-P73495

	*CD117/c-kit* Protein, Human (P10721-2, HEK293, His)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag. The total length of CD117/c-kit Protein, Human (P10721-2, HEK293, His) is 491 a.a., with molecular weight of 75-85 kDa.

HY-P74339

	*CD117/c-kit* Protein, Human (P10721-2, HEK293, Fc)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is 491 a.a., with molecular weight of 93-115 kDa.

HY-P74340

	*CD117/c-kit* Protein, Human (433a.a, sf9, His-GST)** Mast/stem cell growth factor receptor kit; SCFR; CD117; kit; Sl	Human	Sf9 insect cells
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (433a.a, sf9, His-GST) is the recombinant human-derived CD117/c-kit protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CD117/c-kit Protein, Human (433a.a, sf9, His-GST) is 433 a.a., with molecular weight of ~68 kDa.

Cat. No.	Product Name	Chemical Structure

HY-15463S

Imatinib-d8 1 Publications Verification
Imatinib-d₈ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-15463S1

Imatinib-d4
Imatinib-d₄ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4].

HY-G0017S1

N-Desmethyl imatinib-d4
N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d₄ (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-13904S

Flumatinib-d3
Flumatinib-d₃ is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].

HY-10208S

Pazopanib-d6
Pazopanib-d₆ is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-10208S1

Pazopanib-13C,d3
Pazopanib- ¹³C,d₃ is the deuterium and ¹³C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-12009S

Pazopanib-13C,d3 hydrochloride
Pazopanib- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-15463S2

Imatinib-d3 hydrochloride

Imatinib-d₃ (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-10201S2

Sorafenib-13C,d3

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

Cat. No.	Product Name	Application	Reactivity

HY-P80085

c-Kit Antibody (YA502)	WB, IHC-P	Human
c-Kit Antibody (YA502) is a non-conjugated and Rabbit origined monoclonal antibody about 110 kDa, targeting to c-Kit. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80619

c-Kit Antibody kit; SCFR; Mast/stem cell growth factor receptor kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-kit; Tyrosine-protein kinase kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
c-Kit Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 110 kDa, targeting to c-Kit. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P81128

SCF Antibody Stem Cell Factor; C kit ligand; Ckit ligand; DKFZp686F2250; kit ligand; kitl; kitLG; KL 1; KL1; Mast cell growth factor; MGF; SF; SHEP7; Steel factor; Stem cell factor precursor; SCF_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat,
SCF Antibody is an unconjugated, approximately 31 kDa, rabbit-derived, anti-SCF polyclonal antibody. SCF Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, background without labeling.

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