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Results for "

calcineurin

" in MCE Product Catalog:

By Targets:	Antibiotic (5) Apoptosis (1) Autophagy (5) Bacterial (5) Complement System (2) EGFR (1) Endogenous Metabolite (1) FKBP (3) HSP (1) Molecular Glues (2) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (3) Phosphatase (15) Ras (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (13) Metabolic Disease (2) Neurological Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death.

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death.

HY-P0228

Calcineurin substrate	Autophagy	Neurological Disease
Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay.

HY-P0228A

Calcineurin substrate TFA	Autophagy	Metabolic Disease
Calcineurin substrate (TFA) is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate (TFA) can be used in the calcineurin activity assay.

HY-N10186

Dibefurin
Phosphatase Endogenous Metabolite Others

Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase.

Dibefurin	Phosphatase Endogenous Metabolite	Others
Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase.

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 is a tyrosine kinase, with an IC₅₀ of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC₅₀=21 μM).

HY-W181102

NFAT Inhibitor-2	Others	Inflammation/Immunology Neurological Disease Cardiovascular Disease
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17).

HY-106638

Voclosporin
ISAtx-247
Molecular Glues Phosphatase Inflammation/Immunology

Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.

Voclosporin ISAtx-247	Molecular Glues Phosphatase	Inflammation/Immunology
Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

HY-P3338

Cyclosporin A-Derivative 3
Phosphatase Infection

Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with calcineurin inhibition.

Cyclosporin A-Derivative 3	Phosphatase	Infection
Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with *calcineurin* inhibition.

HY-13723

Pimecrolimus SDZ-ASM 981	Phosphatase	Inflammation/Immunology
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active *calcineurin* inhibitor with a K_i of 117 nM. Pimecrolimus shows anti-inflammatory activity.

HY-P1026

NFAT Inhibitor-1 VIVIT peptide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

HY-B2006

Fenvalerate	Phosphatase Bacterial	Infection
Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC₅₀ of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide.

HY-B0579

Cyclosporin A Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Phosphatase Complement System Antibiotic	Inflammation/Immunology Cancer
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of *calcineurin* with an IC₅₀ of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.

HY-13723A

Pimecrolimus hydrate SDZ-ASM 981 hydrate	Phosphatase	Inflammation/Immunology
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active *calcineurin* inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus.

HY-B2006S

Fenvalerate-d5	Phosphatase Bacterial	Infection
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

HY-13756A

Tacrolimus monohydrate FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Phosphatase FKBP Autophagy Bacterial Antibiotic	Cancer Infection Inflammation/Immunology
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

HY-13756

Tacrolimus FK506; Fujimycin; FR900506	Phosphatase FKBP Bacterial Autophagy Antibiotic	Cancer Infection Inflammation/Immunology
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

HY-B0579S

Cyclosporin A-d4 Cyclosporine A-d₄; Ciclosporin A-d₄; CsA-d₄	Phosphatase Complement System Antibiotic	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-108544

INCA-6 Triptycene-1,4-quinone	Nuclear Factor of activated T Cells (NFAT)	Cardiovascular Disease
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling.

HY-13756S

Tacrolimus-13C,d2 FK506-¹³C,d₂; Fujimycin-¹³C,d₂; FR900506-¹³C,d₂	Phosphatase FKBP Bacterial Autophagy Antibiotic	Cancer Infection Inflammation/Immunology
Tacrolimus-¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

HY-114413

YZ129	HSP Apoptosis	Cancer
YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC₅₀ of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.

HY-N0617

Sanggenon C	NF-κB	Cancer Inflammation/Immunology Cardiovascular Disease
Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from Cortex Mori (Sang Bai Pi). Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the *calcineurin/NFAT2* pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC₅₀ of 3.00 μM.

Cat. No.	Product Name	Target	Research Area

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death.

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death.

HY-P0228

Calcineurin substrate	Autophagy	Neurological Disease
Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay.

HY-P0228A

Calcineurin substrate TFA	Autophagy	Metabolic Disease
Calcineurin substrate (TFA) is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate (TFA) can be used in the calcineurin activity assay.

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

HY-P3338

Cyclosporin A-Derivative 3
Phosphatase Infection

Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with calcineurin inhibition.

Cyclosporin A-Derivative 3	Phosphatase	Infection
Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with *calcineurin* inhibition.

HY-P1354

Cyclosporin A-Derivative 2	Peptides	Others
Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P1026

NFAT Inhibitor-1 VIVIT peptide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

HY-P1355

Cyclosporin A-Derivative 1	Peptides	Inflammation/Immunology
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P1355A

Cyclosporin A-Derivative 1 Free base	Peptides	Others
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

Cat. No.	Product Name	Target	Category

HY-N10186

Dibefurin	Phosphatase Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Other Diseases Source classification Microorganisms
Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase.

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Structural Classification Natural Products Microorganisms Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).

HY-B0579

Cyclosporin A Cyclosporine A; Ciclosporin A; CsA	Molecular Glues Phosphatase Complement System Antibiotic	Natural Products Inflammation/Immunology Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Microorganisms
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of *calcineurin* with an IC₅₀ of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.

HY-13756A

Tacrolimus monohydrate FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Phosphatase FKBP Autophagy Bacterial Antibiotic	Antibiotics Structural Classification Macrolide Antibiotics Microorganisms Source classification Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

HY-13756

Tacrolimus FK506; Fujimycin; FR900506	Phosphatase FKBP Bacterial Autophagy Antibiotic	Antibiotics Structural Classification Macrolide Antibiotics Microorganisms Animals Source classification Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.

HY-N0617

Sanggenon C	NF-κB	Phenols Flavanonols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Moraceae Morus alba Linn.
Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from Cortex Mori (Sang Bai Pi). Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the *calcineurin/NFAT2* pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC₅₀ of 3.00 μM.

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Product Name	Species	Source

HY-P7705

Calcineurin B Protein, Human (His) rHuCNB, His; calcineurin Subunit B Type 1; PPP3R1; CNB	Human	E. coli
Calcineurin B Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Calcineurin Subunit B Type 1 is an anti-tumor factor.

HY-P76759

Calcineurin A/PPP3CA Protein, Human (sf9, His)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CALNA; CNA
Human Sf9 insect cells

Cat. No.	Product Name

HY-B2006S

Fenvalerate-d5
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-13756S

Tacrolimus-13C,d2
Tacrolimus-¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

calcineurin

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products