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Results for "

calcium-activated

" in MedChemExpress (MCE) Product Catalog:

24

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1

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3

Peptides

2

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8

Recombinant Proteins

3

Isotope-Labeled Compounds

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Cat. No. Compare Product Name Species Source
  • HY-P72115
    CAPN2 Protein, Human (His)

    calcium-activated neutral proteinase 2; Calpain M-type; Millimolar-calpain; CAPN2; CANPL2

    		 Human E. coli
    CAPN2 (Calpain-2) is a calcium-regulated, non-lysosomal thiol protease known for catalyzing the limited proteolysis of substrates critical for cytoskeletal remodeling and signaling. Notably, CAPN2 proteolytically cleaves MYOC at “Arg-226,” suggesting its involvement in regulating the function of this protein. CAPN2 Protein, Human (His) is the recombinant human-derived CAPN2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CAPN2 Protein, Human (His) is 681 a.a., with molecular weight of ~82.1 kDa.
  • HY-P72113
    CAPN1 Protein, Human (His)
    1 Publications Verification

    Ca2 activated neutral protease; calcium activated neutral proteinase; CANP1; CANPL 1; CANPL1; CAPN 1; CAPN1; Cell proliferation inducing protein 30; Cell proliferation-inducing gene 30 protein; Micromolar Calpain; Micromolar-calpain; Mu Calpain; muCANP; muCL

    		 Human E. coli
    CAPN1 (Calpain-1) is a calcium-regulated non-lysosomal thiol protease that plays a critical role in the limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This protease catalyzes specific cleavage events, including CTBP1 cleavage at "Asn-375," "Gly-387," and "His-409," and activation of caspase-7 (CASP7). CAPN1 Protein, Human (His) is the recombinant human-derived CAPN1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CAPN1 Protein, Human (His) is 714 a.a., with molecular weight of ~85.9 kDa.
  • HY-P72114
    CAPN1 Protein, Mouse (His)

    Capn1; Canp1; Capa1Calpain-1 catalytic subunit; EC 3.4.22.52; calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP

    		 Mouse E. coli
    CAPN1 protein, a calcium-regulated non-lysosomal thiol-protease, facilitates cytoskeletal remodeling and signal transduction. It selectively cleaves substrates involved in these processes, including CTBP1 at 'Asn-375', 'Gly-388', and 'His-410'. CAPN1 also activates caspase-7 (CASP7), highlighting its role in regulating cellular functions. CAPN1 Protein, Mouse (His) is the recombinant mouse-derived CAPN1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CAPN1 Protein, Mouse (His) is 713 a.a., with molecular weight of ~86.1 kDa.
  • HY-P74355
    CANT1 Protein, Human (HEK293, His)

    Soluble calcium-activated nucleotidase 1; SCAN-1; CANT1; SHAPY

    		 Human HEK293
    CANT1, a calcium-dependent nucleotidase, exhibits a pronounced preference for UDP, showcasing its enzymatic activity order as UDP > GDP > UTP > GTP. Notably, its activity towards ADP is minimal, and even lower towards ATP, while it does not hydrolyze AMP and GMP. This substrate specificity has been well-documented in various studies. Beyond its nucleotidase function, CANT1 is implicated in proteoglycan synthesis, underscoring its role in cellular processes related to the production of these essential macromolecules. The distinct substrate preferences and involvement in proteoglycan synthesis highlight the nuanced and specialized functions of CANT1 in cellular metabolism. CANT1 Protein, Human (HEK293, His) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-His labeled tag. The total length of CANT1 Protein, Human (HEK293, His) is 322 a.a., with molecular weight of ~40 kDa.
  • HY-P74356
    CANT1 Protein, Human (HEK293, Fc)

    Soluble calcium-activated nucleotidase 1; SCAN-1; CANT1; SHAPY

    		 Human HEK293
    CANT1, a calcium-dependent nucleotidase, exhibits a pronounced preference for UDP, showcasing its enzymatic activity order as UDP > GDP > UTP > GTP. Notably, its activity towards ADP is minimal, and even lower towards ATP, while it does not hydrolyze AMP and GMP. This substrate specificity has been well-documented in various studies. Beyond its nucleotidase function, CANT1 is implicated in proteoglycan synthesis, underscoring its role in cellular processes related to the production of these essential macromolecules. The distinct substrate preferences and involvement in proteoglycan synthesis highlight the nuanced and specialized functions of CANT1 in cellular metabolism. CANT1 Protein, Human (HEK293, Fc) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CANT1 Protein, Human (HEK293, Fc) is 322 a.a., with molecular weight of ~65 kDa.
  • HY-P702349
    KCNN2 Protein, Rat (Cell-Free, His)

    Small conductance calcium-activated potassium channel protein 2; KCa2.2

    		 Rat E. coli Cell-free
    KCNN2 is a voltage-dependent potassium channel that is activated by intracellular calcium, leading to membrane hyperpolarization. This channel is thought to regulate neuronal excitability by promoting a slow component of postsynaptic hyperpolarization. KCNN2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived KCNN2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNN2 Protein, Rat (Cell-Free, His) is 580 a.a., with molecular weight of 69.9 kDa.
  • HY-P702350
    KCNN4 Protein, Human (Cell-Free, His)

    Intermediate conductance calcium-activated potassium channel protein 4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel

    		 Human E. coli Cell-free
    KCNN4 is a voltage-dependent potassium channel that is activated by intracellular calcium, leading to membrane hyperpolarization and subsequent calcium influx. This channel is critical for the reactivation of naive T cells, helping to maximize calcium influx and promote T cell proliferation. KCNN4 Protein, Human (Cell-Free, His) is the recombinant human-derived KCNN4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KCNN4 Protein, Human (Cell-Free, His) is 427 a.a., with molecular weight of 59.1 kDa.
  • HY-P700616
    ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc)

    anoctamin 1, calcium activated chloride channel; oral cancer overexpressed 2, ORAOV2, TMEM16A, transmembrane protein 16A; anoctamin-1; DOG1; FLJ10261; TAOS2; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); ORAOV2; TMEM16A

    		 Human E. coli
    ANO1/Anoctamin-1 protein, a calcium-activated chloride channel (CaCC), plays diverse roles in cellular functions. It serves as a major contributor to basal and stimulated chloride conductance in airway epithelial cells, impacting tracheal cartilage development and contributing to airway mucus expression induced by interleukins IL3 and IL8, as well as by the asthma-associated protein CLCA1. ANO1 is indispensable for normal functioning of the interstitial cells of Cajal (ICCs), crucial for electrical pacemaker activity in gastrointestinal smooth muscles, and is involved in transepithelial anion transport and smooth muscle contraction. It is also required for CFTR activation and membrane expression, modulating endoplasmic reticulum Ca(2+) store release. Additionally, ANO1 participates in calcium-activated chloride secretion in human sweat gland epithelial cells, showing increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. In sensory neurons, ANO1 acts as a heat sensor and modulates spontaneous firing patterns, contributing to calcium-activated chloride channel activity in taste cells and mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching in dorsal root ganglion neurons. In the developing brain, ANO1 is essential for the Ca(2+)-dependent process extension of radial glial cells. ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) is the recombinant human-derived ANO1/Anoctamin-1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) is 87 a.a., with molecular weight of ~17.6 kDa.

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