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Results for "

cap-dependent

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-143776
    Cap-dependent endonuclease-IN-22

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor .
    <em>Cap-dependent</em> endonuclease-IN-22
  • HY-132894
    Cap-dependent endonuclease-IN-1

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-1 is an orally active cap-dependent endonuclease inhibitor with high potency. Cap-dependent endonuclease-IN-1 can be used for the research of influenza .
    <em>Cap-dependent</em> endonuclease-IN-1
  • HY-143762
    Cap-dependent endonuclease-IN-12

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1 .
    <em>Cap-dependent</em> endonuclease-IN-12
  • HY-143770
    Cap-dependent endonuclease-IN-16

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .
    <em>Cap-dependent</em> endonuclease-IN-16
  • HY-143749
    Cap-dependent endonuclease-IN-6

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-6 (compound 13) is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-6 shows inhibition against influenza virus (EC50=38.21 nM) .
    <em>Cap-dependent</em> endonuclease-IN-6
  • HY-143781
    Cap-dependent endonuclease-IN-26

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains .
    <em>Cap-dependent</em> endonuclease-IN-26
  • HY-143768
    Cap-dependent endonuclease-IN-14

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) .
    <em>Cap-dependent</em> endonuclease-IN-14
  • HY-143769
    Cap-dependent endonuclease-IN-15

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-15 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-15 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-15 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113226327A, compound c-1) .
    <em>Cap-dependent</em> endonuclease-IN-15
  • HY-144065
    Cap-dependent endonuclease-IN-19

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) .
    <em>Cap-dependent</em> endonuclease-IN-19
  • HY-143775
    Cap-dependent endonuclease-IN-20

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-20 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-20 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 4.82 μM (CN112940009A; DSC801) .
    <em>Cap-dependent</em> endonuclease-IN-20
  • HY-143771
    Cap-dependent endonuclease-IN-17

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-17 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-17 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 1.29 μM (CN112898346A; DSC701) .
    <em>Cap-dependent</em> endonuclease-IN-17
  • HY-144068
    Cap-dependent endonuclease-IN-25

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family (extracted from patent WO2020075080A1, compound 4) .
    <em>Cap-dependent</em> endonuclease-IN-25
  • HY-143766
    Cap-dependent endonuclease-IN-13

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) .
    <em>Cap-dependent</em> endonuclease-IN-13
  • HY-143752
    Cap-dependent endonuclease-IN-8

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-8 inhibits replication of orthomyxoviruses (including influenza A, influenza B and influenza C) (extracted from patent CN111410661A, compound I-196) .
    <em>Cap-dependent</em> endonuclease-IN-8
  • HY-143747
    Cap-dependent endonuclease-IN-5

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1) .
    <em>Cap-dependent</em> endonuclease-IN-5
  • HY-143750
    Cap-dependent endonuclease-IN-7

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-7 Inhibits the synthesis of viral mRNA and eventually inhibits virus proliferation. Cap-dependent endonuclease-IN-7 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2020177715A1, compound 5)
    <em>Cap-dependent</em> endonuclease-IN-7
  • HY-144066
    Cap-dependent endonuclease-IN-21

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) .
    <em>Cap-dependent</em> endonuclease-IN-21
  • HY-144067
    Cap-dependent endonuclease-IN-23

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-23 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-23 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-23 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8A or 8B) .
    <em>Cap-dependent</em> endonuclease-IN-23
  • HY-143744
    Cap-dependent endonuclease-IN-3

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-3 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-3 has the potential for the research of influenza A and influenza B infection (extracted from patent WO2019141179A1, compound VI-1) .
    <em>Cap-dependent</em> endonuclease-IN-3
  • HY-143743
    Cap-dependent endonuclease-IN-2

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28) .
    <em>Cap-dependent</em> endonuclease-IN-2
  • HY-143755
    Cap-dependent endonuclease-IN-9

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-9 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-9 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-9 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN112521386A, compound VI-1) .
    <em>Cap-dependent</em> endonuclease-IN-9
  • HY-143757
    Cap-dependent endonuclease-IN-10

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1) .
    <em>Cap-dependent</em> endonuclease-IN-10
  • HY-162242
    Cap-dependent endonuclease-IN-27

    		Influenza Virus Infection
    Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC50 = 12.26 nM) .
    <em>Cap-dependent</em> endonuclease-IN-27
  • HY-155676
    eIF4E-IN-5

    		Eukaryotic Initiation Factor (eIF) Cancer
    eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .
    eIF4E-IN-5
  • HY-109025A
    Baloxavir
    Maximum Cited Publications
    20 Publications Verification

    Baloxavir acid; S-033447

    		 Influenza Virus Infection
    Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
    Baloxavir
  • HY-153570
    Influenza virus-IN-7

    		Influenza Virus Infection
    Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases .
    Influenza virus-IN-7
  • HY-14427
    4E1RCat
    2 Publications Verification

    		 Eukaryotic Initiation Factor (eIF) Autophagy Cancer
    4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM.
    4E1RCat
  • HY-109025
    Baloxavir marboxil
    5 Publications Verification

    S-033188; RG 6152

    		 Influenza Virus Infection
    Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
    Baloxavir marboxil
  • HY-21586B
    7-Methyl-guanosine-5'-triphosphate sodium

    m7GTP sodium

    		 Nucleoside Antimetabolite/Analog Others
    7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
    7-Methyl-guanosine-5'-triphosphate sodium
  • HY-W751835
    Baloxavir-d4
    Maximum Cited Publications
    20 Publications Verification

    Baloxavir acid-d4; S-033447-d4

    		 Isotope-Labeled Compounds Others
    Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
    Baloxavir-d4
  • HY-109025AS
    Baloxavir-d5

    Baloxavir acid-d5; S-033447-d5

    		 Isotope-Labeled Compounds Influenza Virus Infection
    Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity[1][2].
    Baloxavir-d5

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