Search Result

Results for "

caspase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (197) ADC Cytotoxin (1) Adenosine Receptor (1) Adrenergic Receptor (1) AIM2 (1) Akt (7) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (5) Apoptosis (211) Atg8/LC3 (1) Aurora Kinase (2) Autophagy (20) Bacterial (10) Bcl-2 Family (31) Beta-secretase (1) Btk (1) c-Myc (1) Calcium Channel (5) CaMK (1) Casein Kinase (2) Cathepsin (3) CDK (7) CFTR (1) Chloride Channel (2) Cholinesterase (ChE) (2) COX (16) CRISPR/Cas9 (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (4) Drug Metabolite (3) DYRK (1) EGFR (2) Endogenous Metabolite (16) Enolase (1) Epigenetic Reader Domain (1) ERK (9) Eukaryotic Initiation Factor (eIF) (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (2) FKBP (1) Flavivirus (3) FLT3 (3) Fluorescent Dye (15) Free Fatty Acid Receptor (1) Fungal (1) FXR (1) GLUT (1) Glutaminase (3) HDAC (9) Histamine Receptor (1) Histone Demethylase (1) Histone Methyltransferase (1) HIV (3) IAP (5) IGF-1R (2) iGluR (1) Influenza Virus (3) Integrin (5) Interleukin Related (10) Isotope-Labeled Compounds (12) JAK (3) JNK (5) Lactate Dehydrogenase (1) Lipoxygenase (2) MDM-2/p53 (5) MEK (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (2) Molecular Glues (3) mTOR (1) Myosin (2) Na+/Ca2+ Exchanger (1) NF-κB (4) NO Synthase (1) NOD-like Receptor (NLR) (8) Nuclear Hormone Receptor 4A/NR4A (1) Orexin Receptor (OX Receptor) (2) P-glycoprotein (3) p38 MAPK (7) p62 (1) PAK (1) Paraptosis (1) Parasite (7) PARP (16) PGE synthase (1) Phosphatase (3) Phospholipase (1) PI3K (4) Pim (1) PKC (3) Potassium Channel (2) PPAR (2) PROTACs (4) Protease Activated Receptor (PAR) (1) Proteasome (6) Pyroptosis (6) RABV (1) RAR/RXR (1) Reactive Oxygen Species (15) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROR (1) ROS Kinase (2) Salt-inducible Kinase (SIK) (1) SARS-CoV (5) Sigma Receptor (2) Sirtuin (1) Sodium Channel (1) STAT (5) TGF-β Receptor (1) TNF Receptor (5) Topoisomerase (1) TRP Channel (1) Tyrosinase (2) VEGFR (1) Virus Protease (1) Wnt (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (266) Cardiovascular Disease (9) Endocrinology (3) Infection (34) Inflammation/Immunology (78) Metabolic Disease (12) Neurological Disease (33)

By Targets:

Caspase (197)

ADC Cytotoxin (1)

Adenosine Receptor (1)

Adrenergic Receptor (1)

AIM2 (1)

Akt (7)

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Androgen Receptor (2)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (5)

Apoptosis (211)

Atg8/LC3 (1)

Aurora Kinase (2)

Autophagy (20)

Bacterial (10)

Bcl-2 Family (31)

Beta-secretase (1)

Btk (1)

c-Myc (1)

Calcium Channel (5)

CaMK (1)

Casein Kinase (2)

Cathepsin (3)

CDK (7)

CFTR (1)

Chloride Channel (2)

Cholinesterase (ChE) (2)

COX (16)

CRISPR/Cas9 (3)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (4)

Drug Metabolite (3)

DYRK (1)

EGFR (2)

Endogenous Metabolite (16)

Enolase (1)

Epigenetic Reader Domain (1)

ERK (9)

Eukaryotic Initiation Factor (eIF) (1)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (2)

FKBP (1)

Flavivirus (3)

FLT3 (3)

Fluorescent Dye (15)

Free Fatty Acid Receptor (1)

Fungal (1)

FXR (1)

GLUT (1)

Glutaminase (3)

HDAC (9)

Histamine Receptor (1)

Histone Demethylase (1)

Histone Methyltransferase (1)

HIV (3)

IAP (5)

IGF-1R (2)

iGluR (1)

Influenza Virus (3)

Integrin (5)

Interleukin Related (10)

Isotope-Labeled Compounds (12)

JAK (3)

JNK (5)

Lactate Dehydrogenase (1)

Lipoxygenase (2)

MDM-2/p53 (5)

MEK (1)

Microtubule/Tubulin (4)

Mitochondrial Metabolism (2)

Molecular Glues (3)

mTOR (1)

Myosin (2)

Na+/Ca2+ Exchanger (1)

NF-κB (4)

NO Synthase (1)

NOD-like Receptor (NLR) (8)

Nuclear Hormone Receptor 4A/NR4A (1)

Orexin Receptor (OX Receptor) (2)

P-glycoprotein (3)

p38 MAPK (7)

p62 (1)

PAK (1)

Paraptosis (1)

Parasite (7)

PARP (16)

PGE synthase (1)

Phosphatase (3)

Phospholipase (1)

PI3K (4)

Pim (1)

PKC (3)

Potassium Channel (2)

PPAR (2)

PROTACs (4)

Protease Activated Receptor (PAR) (1)

Proteasome (6)

Pyroptosis (6)

RABV (1)

RAR/RXR (1)

Reactive Oxygen Species (15)

Ribosomal S6 Kinase (RSK) (1)

RIP kinase (1)

ROR (1)

ROS Kinase (2)

Salt-inducible Kinase (SIK) (1)

SARS-CoV (5)

Sigma Receptor (2)

Sirtuin (1)

Sodium Channel (1)

STAT (5)

TGF-β Receptor (1)

TNF Receptor (5)

Topoisomerase (1)

TRP Channel (1)

Tyrosinase (2)

VEGFR (1)

Virus Protease (1)

Wnt (1)

β-catenin (1)

γ-secretase (1)

By Research Areas:

Cancer (266)

Cardiovascular Disease (9)

Endocrinology (3)

Infection (34)

Inflammation/Immunology (78)

Metabolic Disease (12)

Neurological Disease (33)

408

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136975

Caspase-3-IN-1

Caspase Neurological Disease Metabolic Disease

Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC₅₀ of 14.5 nM .

Caspase-3-IN-1	Caspase	Neurological Disease Metabolic Disease
Caspase-3-IN-1 (compound 11b) is a potent *Caspase-3* inhibitor, with an IC₅₀ of 14.5 nM .

HY-P1095

Ivachtin caspase-3 Inhibitor VII	Caspase	Cardiovascular Disease Neurological Disease
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl *caspase-3* inhibitor with an IC₅₀ of 23 nM. Ivachtin has modest selectivity for the remaining caspases .

HY-136744

Caspase-9 Inhibitor III Ac-LEHD-cmk	Caspase	Cardiovascular Disease
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a *caspase-9* inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury .

HY-P4222

IETD-CHO

caspase-8-IN-1
Caspase Others

IETD-CHO (Caspase-8-IN-1) is a potent caspase-8 inhibitor .

IETD-CHO caspase-8-IN-1	Caspase	Others
IETD-CHO (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-156154

Caspase-3 activator 1	Pyroptosis	Cancer
Caspase-3 activator 1 (compound 4b) is a Ru(III) metal complex that inhibits gastric tumor growth and metastasis. Caspase-3 activator 1 mediates caspase-3 cleavage, which in turn causes Caspase-3 to cleave gasdermin E (GSDME) to produce the GSDME-N terminus, causing gastric tumor cell membrane perforation. Caspase-3 activator 1 is capable of inducing pyroptosis and pyroptosis-induced immune responses and can be assembled with decitabine DCT (HY-A0004) into a 4b-DCT-Lip lipid delivery system .

HY-152748

Caspase-3/7 activator 1	Apoptosis Caspase	Cancer
Caspase-3/7 activator 1 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 1 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152756

Caspase-3/7 activator 2	Apoptosis Caspase	Cancer
Caspase-3/7 activator 2 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152758

Caspase-3/7 activator 3	Apoptosis Caspase	Cancer
Caspase-3/7 activator 3 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-155389

Caspase-3 activator 2	Caspase	Cancer
Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC₅₀ values of 33.52 μM and 76.90 μM respectively .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-P0034

Ac-DEVD-CMK caspase-3 Inhibitor III
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .

HY-16990

Ac-YVAD-cmk 5+ Cited Publications caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .

HY-P0034A

Ac-DEVD-CMK TFA 1 Publications Verification caspase-3 Inhibitor III TFA	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
HY-P10104

Smac-N7, Penetratin conjugated

Caspase Cancer

Smac-N7, Penetratin conjugated is a caspase activator derived from the second mitochondria-derived activator of caspases (SMAC) .

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity .

Smac-N7, Penetratin conjugated	Caspase	Cancer
Smac-N7, Penetratin conjugated is a *caspase* activator derived from the second mitochondria-derived activator of caspases (SMAC) .

HY-P2012

TRP-601	Caspase Bcl-2 Family	Others
TRP-601 is a *caspase* inhibitor. TRP-601 reversed the increased expression of active *caspase-2*, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .

HY-108312A

AC-VEID-CHO TFA	Caspase	Neurological Disease
AC-VEID-CHO (TFA) is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P1009

Z-YVAD-FMK

10+ Cited Publications

Caspase Cancer

Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .
HY-155613

M867

Caspase Cancer

M867 is a selective and reversible inhibitor of caspase-3 with an IC₅₀ of 1.4 nM and K_i of 0.7 nM. M867 has anti apoptotic activity .
HY-P10083

Ac-VQVD-pNA

Fluorescent Dye Others

Ac-VQVD-pNA is a chromogenic substrate of caspase 3 .

Z-YVAD-FMK 10+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

M867	Caspase	Cancer
M867 is a selective and reversible inhibitor of *caspase-3* with an IC₅₀ of 1.4 nM and K_i of 0.7 nM. M867 has anti apoptotic activity .

Ac-VQVD-pNA	Fluorescent Dye	Others
Ac-VQVD-pNA is a chromogenic substrate of *caspase* 3 .

HY-14570

Triphen diol	Apoptosis	Cancer
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase*-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase*-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P5834

Boc-AEVD-CHO

Caspase Apoptosis Inflammation/Immunology

Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases .
HY-130476

Satratoxin G

Caspase Apoptosis Cancer

Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

Boc-AEVD-CHO	Caspase Apoptosis	Inflammation/Immunology
Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases .

Satratoxin G	Caspase Apoptosis	Cancer
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N8617

Trijuganone C	Caspase	Cancer
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-N10481

Aviculin	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator *caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP*). Aviculin shows an increase in the Bax/Bcl-2 ratio .

HY-10397A

MX1013 2 Publications Verification CV1013; Z-VD-FMK	Caspase	Cancer
MX1013 is a potent, irreversible dipeptide *caspase* inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM .

HY-125018

QM31 SVT016426	Caspase	Cancer
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC₅₀=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint .

HY-N8498

GKK1032B	Apoptosis	Cancer
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-P10146

Ac-LETD-CHO	Caspase	Cancer
Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC₅₀ value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer .

HY-113963

Ac-IETD-CHO	Apoptosis	Cancer
Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and *caspase-8*. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death .

HY-N0530

Dryocrassin ABBA Dryocrassin	Apoptosis Influenza Virus	Cancer
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-120838

Heptelidic acid Koningic acid	Caspase	Infection Cancer
Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of *caspases* . Koningic acid (KA) is a specific GAPDH inhibitor with an IC₅₀of 90 μM .

HY-146253

CDK1/2/4-IN-1	CDK Apoptosis Bcl-2 Family Caspase	Cancer
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC₅₀ values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research .

HY-155570

Anticancer agent 137	PI3K Apoptosis Caspase PARP	Cancer
Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer .

HY-N6818

5,7,4'-Trimethoxyflavone	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of *caspase-3, and degradation of ADP-ribose polymerase (PARP)* protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-122534

Mensacarcin	Mitochondrial Metabolism ADC Cytotoxin Apoptosis	Cancer
Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-P99260

Conatumumab AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody	TNF Receptor	Cancer
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (K_d: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .

HY-111675

Ac-FLTD-CMK 4 Publications Verification	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 .

HY-P1169

Ac-IETD-AFC

Caspase Others

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

Ac-IETD-AFC	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-121320

Raptinal 3 Publications Verification	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates *caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase*-9 .

HY-P2569

Malformin A1	Apoptosis	Cancer
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-122928

Rosamultic acid	Apoptosis Caspase	Cancer
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of *caspases* .

HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
HY-P5122

Z-LEED-FMK

Caspase Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-149721

HDAC4-IN-1	Apoptosis HDAC	Cancer
HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC₅₀=0.077 μM). HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer .

HY-13686

PQ401 2 Publications Verification	IGF-1R Apoptosis	Cancer
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC₅₀ of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC₅₀, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library

1256 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1256 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L175

Inflammasomes related Compound Library

67 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 67 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

HY-L003

Apoptosis Compound Library

2218 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 2218 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

HY-L144

Mitochondrial Protection Compound Library

583 compounds

Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases.

The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 583 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-P1169

Ac-IETD-AFC

Fluorescent Dyes/Probes

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
HY-P1093

Ac-LEHD-AFC

Chromogenic Substrates

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dyes/Probes
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dyes/Probes
FITC-C6-LEHD-FMK, a fluorescently labeled *caspase-9* inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2

Fluorescent Dyes/Probes

Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P3362

Ac-IETD-AMC	Fluorescent Dyes/Probes
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P1986

Z-DEVD-AFC	Fluorescent Dyes/Probes
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH

Chromogenic Substrates

Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Chromogenic Substrates
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P3363

Z-DEVD-AMC	Chromogenic Substrates
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-P2208

Z-IETD-AFC

Fluorescent Dyes/Probes

Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .
HY-P2377

Ac-YVAD-AFC

Dyes

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
HY-P2616

Mca-YVADAP-Lys(Dnp)-OH

Chromogenic Substrates

Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
HY-P2065

Ac-VEID-AMC

Fluorescent Dyes/Probes

Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P3110

Ac-DNLD-AMC	Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0530

Dryocrassin ABBA Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N8617

Trijuganone C	Quinones Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Benzene Quinones Plants Naphthalene Quinones	Caspase
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-N10481

Aviculin	Classification of Application Fields Polygonum aviculare L. Polygonaceae Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Bcl-2 Family
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC₅₀ of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator *caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP*). Aviculin shows an increase in the Bax/Bcl-2 ratio .

HY-N8498

GKK1032B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Apoptosis
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-N6818

5,7,4'-Trimethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of *caspase-3, and degradation of ADP-ribose polymerase (PARP)* protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-P2569

Malformin A1	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-122928

Rosamultic acid	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Rosa multifoloraThunb	Apoptosis Caspase
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of *caspases* .

HY-N2741

Vitexin B-1	Structural Classification Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of *Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis* in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N0605

Ginsenoside Rh2 3 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-19696

Tauroursodeoxycholate Maximum Cited Publications 56 Publications Verification Tauroursodeoxycholic acid; TUDCA; UR 906	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-19696A

Tauroursodeoxycholate sodium Maximum Cited Publications 56 Publications Verification Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 56 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK* .

HY-N3376

Liriodenine Spermatheridine; VLT045	Alkaloids Classification of Application Fields Source classification Magnoliaceae Pyridine Alkaloids Plants Liriodendron chinense (Hemsl.) Sarg. Disease Research Fields Cancer	Apoptosis
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

HY-N6861

Lucidenic acid B	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard); Ginsenoside-Rh2 (Standard)	Panax ginseng C. A. Meyer Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-N9942

Physalin A	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Source classification Plants Solanaceae Disease Research Fields Cancer	Apoptosis Autophagy
Physalin A is a withanolide isolated from Physalis alkekengi var. franchetii. Physalin A induces apoptosis associated with up-regulation of caspase-3 and caspase-8 expression. Physalin A induces autophagy, found to antagonize apoptosis in HT1080 cells. Physalin A has the potential for the research of cancer disease .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and *caspase‑3*.

HY-W010201

Citronellol 1 Publications Verification (±)-Citronellol; (±)-β-Citronellol	Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Geraniaceae Cancer	Reactive Oxygen Species
Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-N6681

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae Disease Research Fields Cancer	Apoptosis
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-W010201R

Citronellol (Standard) (±)-Citronellol (Standard); (±)-β-Citronellol (Standard)	Structural Classification Classification of Application Fields Terpenoids Source classification Plants Geraniaceae Disease Research Fields Cancer	Reactive Oxygen Species
Citronellol (Standard) is the analytical standard of Citronellol. This product is intended for research and analytical applications. Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-N2632

Uvarigrin	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Apoptosis
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-N0674A

Dehydrocorydaline chloride 20+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0702

Tenuifolin	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	Beta-secretase Cholinesterase (ChE)
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

HY-N0674

Dehydrocorydaline 20+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Structural Classification Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674B

Dehydrocorydaline (hydroxyl) 20+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 20+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N2490

Dehydrotrametenolic acid	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology	Caspase Apoptosis
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through *caspase-3* pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates *caspase*-3, -8, and -9, leading to PARP/ cleavage .

HY-N8464

Juncuenin D	Structural Classification Natural Products Juncaceae Source classification Plants Juncus acutus L.	Bacterial
Juncuenin D induces *caspase-3*-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .

HY-N6690

Destruxin B	Infection Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates *caspase-3* and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo .

HY-N0551

Wedelolactone 10+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced *caspase-11* expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N12503

Patuletin	Structural Classification Flavonols Flavonoids Source classification Amaranthaceae Plants Spinacia oleracea L.	Apoptosis Caspase
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce *caspase-3* activation .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Derris indica	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-N3584

Paris saponin VII 1 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N2602

Sanggenol L	Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-N0809

Sesamolin 2 Publications Verification	Sesamum indicum Linn. Source classification Other Phenylpropanoids Phenylpropanoids Pedaliaceae Plants	p38 MAPK JNK Caspase
Sesaminol, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and *caspase-3* but not ERK-MAPK expression .

HY-N0817

Polyphyllin G	Structural Classification Classification of Application Fields Paris fargesii var. petiolata (Baker ex C.H.Wright) Wang et Tang Cardiacglycosides Source classification Plants Melanthiaceae Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides Steroids	Apoptosis Autophagy Bacterial
Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs) . Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy .

HY-Y0152

Cinchonine 2 Publications Verification (8R,9S)-Cinchonine; LA40221	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Quinoline Alkaloids Plants Disease Research Fields Cancer Cinchona ledgeriana (Howard) Moens et Trim	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N7930

Crenulatin	Structural Classification Classification of Application Fields Source classification Crassulaceae Other Diseases Plants Disease Research Fields Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Saccharides	Others
Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity .

HY-N2369

Chelidonine	Infection Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Apoptosis Influenza Virus
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-W748591

Cannflavin A	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-59001

Sappanchalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

Recombinant Proteins Recommended:

Caspase

Species:	Human (13)
Tag:	His (9) Tag Free (3) Strep (1) Myc (1) GST (1)
Source:	HEK293 (1) P. pastoris (1) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P7743

	Caspase-14/CASP14 Protein, Human (His) rHucaspase-14, His; caspase-14; CASP-14; CASP14	Human	E. coli
	Caspase-14 Protein, Human (His) is an approximately 31.0 kDa caspase-14 protein with a His-flag. Caspase-14 is a seemingly non-apoptotic caspase involved in keratinocyte differentiation and cornification.

HY-P74347

	Caspase-7/CASP7 Protein, Human (His) CMH-1; CASP-7; caspase-7; MCH3; ICE-LAP3	Human	E. coli
	Caspase-7/CASP7 protein is a thiol protease involved in programmed cell death processes such as apoptosis, pyroptosis, and granzyme-mediated death. It is activated by initiating caspases (CASP8, CASP9 and/or CASP10) and cleaves CLSPN, PARP1, PTGES3 and YY1, mediating apoptosis. Caspase-7/CASP7 Protein, Human (His) is the recombinant human-derived Caspase-7/CASP7 protein, expressed by E. coli , with C-His labeled tag. The total length of Caspase-7/CASP7 Protein, Human (His) is 303 a.a., with molecular weight of ~20 & 11 kDa, respectively.

HY-P7742

	Caspase-10/CASP10 Protein, Human (His) rHucaspase-10, His; caspase-10; CASP-10; Apoptotic Protease Mch-4; ICE-Like Apoptotic Protease 4; CASP10; MCH4	Human	E. coli
	Caspase-10 Protein, Human (His) is an approximately 33.0 kDa caspase-10 protein with a His-flag, expressed in E. coli. Caspase-10 belongs to the caspase family and involved in the execution-phase of cell apoptosis.

HY-P701341

	Caspase-3/CASP3 Protein, Human CASP3; caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	Human	E. coli
	Caspase-3/CASP3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. Caspase-3/CASP3 Protein, Human is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with tag free. The total length of Caspase-3/CASP3 Protein, Human is 248 a.a., .

HY-P701342

	Caspase-3/CASP3 Protein, Human (His, Strep) CASP3; caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	Human	E. coli
	Caspase-3/CASP3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. Caspase-3/CASP3 Protein, Human (His, Strep) is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of Caspase-3/CASP3 Protein, Human (His, Strep) is 277 a.a., .

HY-P72117

	Caspase-1/CASP1 Protein, Human (GST) CASP-1; CASP1; CASP1_HUMAN; caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (GST) is the recombinant human-derived Caspase-1/CASP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of Caspase-1/CASP1 Protein, Human (GST) is 150 a.a., with molecular weight of ~43.8 kDa.

HY-P702188

	NLRP1 Protein, Human NLRP1; NACHT; LRR and PYD domains-containing protein 1; caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain	Human	E. coli
	The NLRP1 protein is a key sensor in the NLRP1 inflammasome and can trigger pyroptosis in response to multiple pathogen-related signals. It acts as a pattern recognition receptor (PRR), recognizes pathogens and damage-related signals, and initiates inflammasome complex formation and CASP1 activation. NLRP1 Protein, Human is the recombinant human-derived NLRP1 protein, expressed by E. coli , with tag free. The total length of NLRP1 Protein, Human is 84 a.a., .

HY-P702189

	NLRP1 Protein, Human (His) NLRP1; NACHT; LRR and PYD domains-containing protein 1; caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain	Human	E. coli
	The NLRP1 protein is a key sensor in the NLRP1 inflammasome and can trigger pyroptosis in response to multiple pathogen-related signals. It acts as a pattern recognition receptor (PRR), recognizes pathogens and damage-related signals, and initiates inflammasome complex formation and CASP1 activation. NLRP1 Protein, Human (His) is the recombinant human-derived NLRP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of NLRP1 Protein, Human (His) is 84 a.a., .

HY-P71708

	Caspase-8/CASP8 subunit p18 Protein, Human (His) ALPS2B; CASP-8; ICE-like apoptotic protease 5	Human	E. coli
	The Caspase-8/CASP8 subunit p18 protein is a key thiol protease that acts as a molecular switch in programmed cell death processes, including apoptosis, necroptosis, and pyroptosis. It is essential for preventing tissue damage by inducing exogenous apoptosis by cleaving and activating effector caspases. Caspase-8/CASP8 subunit p18 Protein, Human (His) is the recombinant human-derived Caspase-8/CASP8 subunit p18 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Caspase-8/CASP8 subunit p18 Protein, Human (His) is 158 a.a., with molecular weight of ~21.9 kDa.

HY-P70050

	CRADD Protein, Human rHuDeath domain-containing protein CRADD/CRADD; Death Domain-Containing Protein CRADD; caspase and RIP Adapter with Death Domain; RIP-Associated Protein with A Death Domain; CRADD; RAIDD	Human	E. coli
	As an adapter protein, CRADD forms a PIDDosome complex with PIDD1 and CASP2, activates CASP2 and initiates apoptosis. It also recruits CASP2 to the TNFR-1 signaling complex in the tumor necrosis factor-mediated pathway, interacting with RIPK1 and TRADD. CRADD Protein, Human is the recombinant human-derived CRADD protein, expressed by E. coli , with tag free. The total length of CRADD Protein, Human is 199 a.a., with molecular weight of ~21.0 kDa.

HY-P701227

	CEBPA Protein, Human (His) Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; C/ebpalpha; CAP4; caspase 8 precursor; CBF-A; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBP A; CEBP alpha; Cebpa; CEBPA_HUMAN; FADD homologous; ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH	Human	E. coli
	CEBPA protein, also known as CCAAT/enhancer-binding protein α, is a transcription factor that plays a crucial role in regulating the expression of genes related to cell differentiation, proliferation, and metabolism. The reference paragraph states that CEBPA protein interacts with TAF1A and UBTF. CEBPA Protein, Human (His) is the recombinant human-derived CEBPA protein, expressed by E. coli , with N-His labeled tag. The total length of CEBPA Protein, Human (His) is 358 a.a., with molecular weight of ~44 kDa.

HY-P701308

	PYCARD Protein, Human (HEK293, His-Myc) PYCARD; PYD And CARD Domain Containing; CARD5; ASC; Apoptosis-Associated Speck-Like Protein Containing A CARD; TMS-1; caspase Recruitment Domain-Containing Protein 5; TMS1; PYD And CARD Domain-Containing Protein; TMS; HASC	Human	HEK293
	PYCARD proteins are key mediators of apoptosis and inflammation and promote caspase-mediated apoptosis, specifically involving caspase-8 and, in certain cells, caspase-9. It activates the mitochondrial apoptotic pathway, promoting caspase-8-dependent BID maturation and BAX-dependent apoptosis through caspase-9, -2, and -3. PYCARD Protein, Human (HEK293, His-Myc) is the recombinant human-derived PYCARD protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag. The total length of PYCARD Protein, Human (HEK293, His-Myc) is 195 a.a., with molecular weight of ~30 kDa.

HY-P700624

	RIPK2 Protein, Human (P. pastoris, His) receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30	Human	P. pastoris
	RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6His, C-6His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

Cat. No.	Product Name	Chemical Structure

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S

Tauroursodeoxycholate-d5
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-W020050S

Cystamine-d8 (dihydrochloride）

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅is the deuterium labeledTaurodeoxycholic acid(HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-N6801S

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

Cat. No.	Product Name	Application	Reactivity

HY-P80044

Caspase-10 Antibody	WB, IHC-P, FC, IP	Human
Caspase-10 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 59 kDa, targeting to Caspase-10. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human.

HY-P80045

Caspase-14 Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
Caspase-14 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 28 kDa, targeting to Caspase-14. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

HY-P80046

Caspase-3 Antibody	WB, ICC/IF, IHC-P, IP, FC	Human
Caspase-3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to Caspase-3. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human.

HY-P80047

Caspase-6 Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
Caspase-6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to Caspase-6. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83435

Caspase 14 Antibody (YA3180)

CASP14; caspase-14; caspase 14; MICE; CASP-14
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

HY-P80049

Caspase-8 Antibody	WB, ICC/IF, IHC-P	Human
Caspase-8 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 55 kDa, targeting to Caspase-8. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human.

HY-P80050

Caspase-9 Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse
Caspase-9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 46 kDa, targeting to Caspase-9. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P83027

*Cleaved-Caspase* 2 Antibody (YA2772)** caspase-2; caspase 2; caspase2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1; CASP2; ICH1; NEDD2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P80589

Caspase 7 Antibody Mch3; CMH-1; mCASP-7; AI314680; ICE-IAP3; caspase-7	WB, ICC/IF, IP	Mouse, Rat
Caspase 7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Caspase 7. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Mouse, Rat.

HY-P81812

Caspase 6 Antibody (YA1557)

CASP6; MCH2; caspase-6; CASP-6; Apoptotic protease Mch-2
WB Human, Rat

HY-P81252

Caspase-5 p20 Antibody caspase-5 subunit p20; Apoptosis related cysteine protease; CASP 5; CASP5; caspase-5; caspase5; caspase 5 apoptosis related cysteine peptidase; caspase 5 apoptosis related cysteine protease; ICE; ICE(rel) III; ICE(rel)III; ICEREL III; ICERELIII; ICH 3; ICH 3 protease; ICH3; ICH3 protease; MGC141966; TY; TY protease.	WB, IHC-P, IHC-F, IF, ELISA	Human, Mouse (predicted: Rat, Rabbit, Pig, Cow, Dog, Horse)

HY-P80588

Caspase 11 Antibody Caspl; ich-3; CASP-4; Casp11; CASP-11	WB, IP	Human, Mouse, Rat
Caspase 11 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to Caspase 11. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80048

Caspase-6 p18 Antibody	WB, IP	Human
Caspase-6 p18 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to Caspase-6 p18. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P81095

Caspase-12 Antibody UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat,
Caspase-12 Antibody is an unconjugated, approximately 46 kDa, rabbit-derived, anti-Caspase-12 polyclonal antibody. Caspase-12 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.

HY-P80623

*Cleaved-Caspase* 3 p12 Antibody** CASP3; CPP32; caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1	WB, ICC/IF	Human, Mouse, Rat
Cleaved-Caspase 3 p12 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to Cleaved-Caspase 3 p12. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80587

Caspase 1 Antibody CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, IHC-P, ELISA	Human, Mouse, Rat
Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Caspase 1. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P81232

Caspase-1 p20 Antibody caspase-1 isoform alpha p20 subunit; CASP1; ICE; IL1BC; caspase-1 subunit p20; CASP 1; caspase 1 apoptosis related cysteine peptidase; caspase 1 apoptosis related cysteine protease; caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat,
Caspase-1 p20 Antibody is an unconjugated, approximately 20/46 kDa, rabbit-derived, anti-Caspase-1 p20 polyclonal antibody. Caspase-1 p20 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P80622

*Cleaved-Caspase* 1 Antibody** CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, ICC/IF, IHC-F, IHC-P, ELISA	Human, Mouse
Cleaved-Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Cleaved-Caspase 1. It can be used for WB,ICC/IF,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse.

HY-P82621

Caspase 10 Antibody (YA2366) CASP10; MCH4; caspase-10; CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4	WB, IHC-P, IP	Human

HY-P81251

CASP4 Antibody caspase-4 subunit 2; caspase-4 subunit p10; caspase-11; CASP-11; Protease ICH-3; Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; caspase 4 apoptosis related cysteine peptidase; caspase-4 subunit 2; caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; ICH 2 protease; ICH2; Mih1/TX; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; EC:3.4.22.64.	WB, ELISA	Rat (predicted: Mouse)

HY-P80582

CARD9 Antibody caspase recruitment domain-containing protein 9; hCARD9	WB	Human
CARD9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 62 kDa, targeting to CARD9. It can be used for WB assays with tag free, in the background of Human.

HY-P80624

*Cleaved-Caspase* 8 Antibody** CASP8; MCH5; caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
Cleaved-Caspase 8 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 55 kDa, targeting to Cleaved-Caspase 8. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81161

CEBP-alpha Antibody Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; CAP4; caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; CEBPA; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog; CEBP α, CEBP-α.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Rat(predicted: Mouse, Dog, Pig, Cow, Rabbit, Sheep, Goat)
CEBP-alpha Antibody is an unconjugated, approximately 39 kDa, rabbit-derived, anti-CEBP-alpha polyclonal antibody. CEBP-alpha Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, rat, and predicted: mouse, dog, pig, cow, rabbit, sheep, goat background without labeling.

HY-P80548

ASC Antibody 1 Publications Verification PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
ASC Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to ASC. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80522

TMS1 Antibody PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1	WB, ICC/IF, FC	Human
TMS1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to TMS1. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human.

HY-P80964

*Cleaved-Caspase* 9 Antibody**	WB , IP	Human, Mouse
Cleaved-Caspase 9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 46 kDa, targeting to Cleaved-Caspase 9. It can be used for WB, IP assays with tag free, in the background of Human, Mouse.

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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