caspase-1/3r

By Targets:	Caspase (41) 5-HT Receptor (5) ADC Linker (4) Adenosine Receptor (5) AIM2 (1) Amino Acid Derivatives (16) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (14) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (8) c-Met/HGFR (1) Calcium Channel (3) Cathepsin (1) CDK (2) CGRP Receptor (1) Cholinesterase (ChE) (3) ClpP (1) COX (2) DNA/RNA Synthesis (4) Dopamine Receptor (11) Drug Metabolite (5) E3 Ligase Ligand-Linker Conjugates (5) EGFR (1) Endogenous Metabolite (12) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (1) Ferroptosis (2) FLT3 (1) Fluorescent Dye (3) Glutathione Peroxidase (1) HCV (2) Histamine Receptor (17) Histone Methyltransferase (2) HIV (2) HMG-CoA Reductase (HMGCR) (2) Influenza Virus (2) Insulin Receptor (1) Integrin (2) Interleukin Related (8) Isotope-Labeled Compounds (12) JAK (2) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) LPL Receptor (2) mAChR (2) MAGL (1) Melanocortin Receptor (10) mGluR (2) MicroRNA (1) Monoamine Oxidase (3) Monoamine Transporter (2) Neurokinin Receptor (6) NF-κB (1) NOD-like Receptor (NLR) (10) Nucleoside Antimetabolite/Analog (5) Opioid Receptor (3) Orexin Receptor (OX Receptor) (1) P2X Receptor (3) p62 (1) Parasite (1) Phosphatase (2) PI3K (1) Pim (1) Potassium Channel (1) Pyroptosis (3) Reactive Oxygen Species (3) RIP kinase (1) SARS-CoV (2) Sigma Receptor (2) Small Interfering RNA (siRNA) (12) Sodium Channel (1) Somatostatin Receptor (1) TNF Receptor (2) Topoisomerase (1) TRP Channel (3) Tyrosinase (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (50) Cardiovascular Disease (6) Endocrinology (14) Infection (11) Inflammation/Immunology (60) Metabolic Disease (19) Neurological Disease (53)
Click Chemistry:	Azide (10)

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16990

Ac-YVAD-cmk 5+ Cited Publications caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

HY-14664F

(3R,5S)-Fluvastatin sodium (3r,5S)-XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy	Cancer
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway ^[1] ^[3].

HY-130774

Ponceau 3R

Fluorescent Dye Others

Ponceau 3R is an azo dye and can be used as a food colorant ^[1].
HY-12422C

rel-(2S,3R)-Voruciclib

CDK Cancer

rel-(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. (2S,3R)-Voruciclib is an orally active CDK inhibitor ^[1].
HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium

(3r,5S)-XU 62-320-d₇
Isotope-Labeled Compounds Others

(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium[1].

Ponceau 3R	Fluorescent Dye	Others
Ponceau 3R is an azo dye and can be used as a food colorant ^[1].

rel-(2S,3R)-Voruciclib	CDK	Cancer
rel-(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. (2S,3R)-Voruciclib is an orally active CDK inhibitor ^[1].

(3R,5S)-Fluvastatin-d7 sodium (3r,5S)-XU 62-320-d₇	Isotope-Labeled Compounds	Others
(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium[1].

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Phosphatase	Metabolic Disease
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research ^[1].

HY-133872

[(3R)-3-Hydroxydodecanoyl]-L-carnitine

Endogenous Metabolite Others

[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite ^[1].

[(3R)-3-Hydroxydodecanoyl]-L-carnitine	Endogenous Metabolite	Others
[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite ^[1].

HY-B0590B

(+)-Tetrabenazine (+)-TBZ; (3r,11bR)-TBZ; (3r,11bR)-Tetrabenazine	Monoamine Transporter	Cancer
(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.

HY-135406

(3R,5R)-Rosuvastatin Lactone

Others Cardiovascular Disease Metabolic Disease

(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

(3R,5R)-Rosuvastatin Lactone	Others	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-109022A

(3R,5R,6S)-Atogepant (3r,5R,6S)-MK-8031; (3r,5R,6S)-AGN-241689	CGRP Receptor	Neurological Disease
(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

HY-W012864S1

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1

Isotope-Labeled Compounds Others

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
HY-W012864S2

(2S,3R)-2,3,4-Trihydroxybutanal-13C-2

Isotope-Labeled Compounds Others

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-2 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
HY-40354D

(3R,4S)-Tofacitinib

JAK Inflammation/Immunology

(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC₅₀ of 1 nM.

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].

(2S,3R)-2,3,4-Trihydroxybutanal-13C-2	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-2 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].

(3R,4S)-Tofacitinib	JAK	Inflammation/Immunology
(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib inhibits *JAK3* with IC₅₀ of 1 nM.

HY-116227

(2S,3R)-LP99	Epigenetic Reader Domain	Inflammation/Immunology
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an K_D of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion ^[1].

HY-14664B

(3R,5S)-Fluvastatin (3r,5S)-XU 62-320 free acid
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway ^[1] ^[3].

HY-N1976

(+)-(3R,8S)-Falcarindiol (3r,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol
(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC₅₀ of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra ^[1] . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-129214

(2S,3R)-DEPMPO-Biotin	Reactive Oxygen Species	Inflammation/Immunology
(2S,3R)-DEPMPO-Biotin is a spin trapping agent consists of DEPMPO (HY-120976) and Biotin (HY-B0511). (2S,3R)-DEPMPO-Biotin captures macromolecule free radicals in lesions ^[1].

HY-121161B

(2S,3R)-Brassinazole	Others	Metabolic Disease
(2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz ^[1] ^[3].

HY-122938

Ceplignan (2S,3r)-Ceplignan	Others	Others
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan ^[1].

HY-137440B

(2R,3R)-Firazorexton (2R,3r)-TAK-994 free base	Orexin Receptor (OX Receptor)	Neurological Disease
(2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms ^[1]..

HY-N8186

(3R)-7,4’-Dihydrohomoisoflavanone	Bacterial	Infection
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against *S. aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)** ^[1].

HY-100823

(1S,3R)-ACPD

mGluR Neurological Disease

(1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells ^[1].

(1S,3R)-ACPD	mGluR	Neurological Disease
(1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells ^[1].

HY-132294A

(1S,3R)-GNE-502	Estrogen Receptor/ERR	Cancer
(1S,3R)-GNE-502 (compound 179) is a potent ERα degrader with an EC₅₀ value of 13 nM against ERα in MCF7 HCS. (1S,3R)-GNE-502 can be used to research cancer related with estrogen receptor ^[1].

HY-12422B

(2S,3R)-Voruciclib hydrochloride

CDK Cancer

rel-(2S,3R)-Voruciclib hydrochloride is the enantiomer of Voruciclib hydrochloride. Voruciclib is an orally active CDK inhibitor.

(2S,3R)-Voruciclib hydrochloride	CDK	Cancer
rel-(2S,3R)-Voruciclib hydrochloride is the enantiomer of Voruciclib hydrochloride. Voruciclib is an orally active CDK inhibitor.

HY-151663

Fmoc-Abu(3-N3) (2R,3R) Fmoc-Abu(3-N3)-OH (2R,3r)	ADC Linker	Others
Fmoc-Abu(3-N3) (Fmoc-Abu(3-N3)-OH) (2R,3R) is a click chemistry reagent containing an azide group. Fmoc-Abu(3-N3) (2R,3R) can be used for the research of various biochemical ^[1].

HY-N10862

(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan	Others	Others
(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan is a natural product that can be isolated from the red resin of Dracaena cochinchinensis ^[1].

HY-W015954

(2R,3R)-Butane-2,3-diol

Endogenous Metabolite Metabolic Disease

(2R,3R)-Butane-2,3-diol is an endogenous metabolite.

(2R,3R)-Butane-2,3-diol	Endogenous Metabolite	Metabolic Disease
(2R,3R)-Butane-2,3-diol is an endogenous metabolite.

HY-17504C

(3R,5R)-Rosuvastatin	HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM ^[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM . Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels ^[3].

HY-103555

NPEC-caged-(1S,3R)-ACPD

Biochemical Assay Reagents Others

NPEC-caged-(1S,3R)-ACPD is a specific photosensitive ligand for glutamate receptor subtypes.

NPEC-caged-(1S,3R)-ACPD	Biochemical Assay Reagents	Others
NPEC-caged-(1S,3R)-ACPD is a specific photosensitive ligand for glutamate receptor subtypes.

HY-116463C

(2R,3R)-E1R	Sigma Receptor	Neurological Disease
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders ^[1].

HY-W140881

(3R,4R)-4-(benzyloxy)-3-((tert-butoxycarbonyl)amino)pentanoic acid	Amino Acid Derivatives	Others
(3R,4R)-4-(benzyloxy)-3-((tert-butoxycarbonyl)amino)pentanoic acid is a threonine derivative ^[1].

HY-151689

(2S,3R)-Fmoc-Abu(3-N3)-OH	ADC Linker	Others
(2S,3R)-Fmoc-Abu(3-N3)-OH is a click chemistry reagent containing an azide group. (2S,3R)-Fmoc-Abu(3-N3)-OH can be used for the research of various biochemical ^[1].

HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].
HY-W040333

(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride

Amino Acid Derivatives Others

(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride is a threonine derivative ^[1].
HY-W012864S

(2S,3R)-2,3,4-Trihydroxybutanal-13C

Isotope-Labeled Compounds Others

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C is the ¹³C labeled N-acetyl-D-talosamine[1].

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].

(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride	Amino Acid Derivatives	Others
(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride is a threonine derivative ^[1].

(2S,3R)-2,3,4-Trihydroxybutanal-13C	Isotope-Labeled Compounds	Others
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C is the ¹³C labeled N-acetyl-D-talosamine[1].

HY-W074264

(2R,3R)-2-Hydroxy-3-methylpentanoic acid	Biochemical Assay Reagents	Others
(2R,3R)-2-Hydroxy-3-methylpentanoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-112929B

(1S,2S,3R)-DT-061 1 Publications Verification	Phosphatase	Cancer
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis ^[1].

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3r,4S)-4-Hydroxy-L-isoleucine; Hydroxyisoleucine	Others	Metabolic Disease
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity ^[1].

HY-15793A

Trans (2,3)-Dihydrotetrabenazine (2R,3r,11bR)-rel-Dihydrotetrabenazine; (2R,3r,11bR)-rel-DHTBZ	Drug Metabolite Monoamine Transporter	Neurological Disease
Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2) ^[1].

HY-W014076

(2S,3R)-2-((S)-2-Amino-3-methylbutanamido)-3-hydroxybutanoic acid	Amino Acid Derivatives	Others
(2S,3R)-2-((S)-2-Amino-3-methylbutanamido)-3-hydroxybutanoic acid is a threonine derivative ^[1].

HY-111532

(3R,4R)-A2-32-01 1 Publications Verification	ClpP Bacterial	Infection
(3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor ^[1].

HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate ^[1].

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate ^[1].

HY-78932C

(2S,3R)-Dap-NE hydrochloride	Others	Cancer
(2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity ^[1].

HY-78932D

(2R,3R)-Dap-NE hydrochloride	Others	Cancer
(2R,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity ^[1].

HY-108059

β-Cryptoxanthin (3r)-β-Cryptoxanthin	Endogenous Metabolite	Neurological Disease
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect ^[1].

HY-W021425

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride	Endogenous Metabolite	Metabolic Disease
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-Z1430S

(3R,4S)-Paroxetine-d4 hydrochloride (3r,4S)-BRL29060-d₄ hydrochloride; (3r,4S)-BRL29060A-d₄	Drug Metabolite Isotope-Labeled Compounds	Others
Paroxetine EP impurity D-d₄ (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity）.

HY-135374

(3R,5S)-Atorvastatin sodium	Drug Metabolite	Metabolic Disease Inflammation/Immunology
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively ^[1] ^[3].

HY-151836

(2S,3R)-H-Abu(3-N3)-OH hydrochloride	ADC Linker	Others
(2S,3R)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group ^[1]. (2S,3R)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-19322C

(1S,3R,5R)-PIM447 dihydrochloride (1S,3r,5R)-LGH447 dihydrochloride	Pim	Cancer
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC₅₀ values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library

1240 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1240 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L175

Inflammasomes related Compound Library

65 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 65 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-P2377

Ac-YVAD-AFC

Dyes

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .
HY-P1093

Ac-LEHD-AFC

Chromogenic Substrates

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
HY-P2616

Mca-YVADAP-Lys(Dnp)-OH

Chromogenic Substrates

Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

Cat. No.	Product Name	Type

HY-W002421

(R)-3-(Boc-amino)pyrrolidine	Biochemical Assay Reagents
tert-butyl N-[(3R)-pyrrolidin-3-yl]carbamate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y1131

Ethyl (R)-3-hydroxybutyrate Ethyl (R)-3-hydroxybutanoate	Biochemical Assay Reagents
Ethyl (R)-3-hydroxybutyrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W001294

(R)-(-)-N-Boc-3-pyrrolidinol	Biochemical Assay Reagents
(R)-(-)-Boc-3-pyrrolidinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40022

(R)-1-Boc-3-Hydroxypiperidine	Biochemical Assay Reagents
(R)-1-Boc-3-Hydroxypiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W074264

(2R,3R)-2-Hydroxy-3-methylpentanoic acid	Biochemical Assay Reagents
(2R,3R)-2-Hydroxy-3-methylpentanoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40097

(R)-1-Boc-3-aminopyrrolidine	Biochemical Assay Reagents
(R)-1-Boc-3-aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40041

(R)-1-Boc-3-methyl-piperazine	Biochemical Assay Reagents
(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2994

3-Hydroxybutyrate dehydrogenase 3-HBDH	Biochemical Assay Reagents
3-Hydroxybutyrate dehydrogenase (3-HBDH) is a mitochondrial enzyme, is often used in biochemical studies. 3-hydroxybutyrate dehydrogenase is involved in the synthesis and degradation of ketone bodies and butanoate metabolism. 3-Hydroxybutyrate dehydrogenase catalyzes (R)-3-hydroxybutanoate converts into acetoacetate ^[1].

Cat. No.	Product Name	Target	Research Area

HY-W140881

(3R,4R)-4-(benzyloxy)-3-((tert-butoxycarbonyl)amino)pentanoic acid	Amino Acid Derivatives	Others
(3R,4R)-4-(benzyloxy)-3-((tert-butoxycarbonyl)amino)pentanoic acid is a threonine derivative ^[1].

HY-W040333

(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride

Amino Acid Derivatives Others

(2S,3R)-Ethyl 2-amino-3-hydroxybutanoate hydrochloride is a threonine derivative ^[1].
HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].

HY-W014076

(2S,3R)-2-((S)-2-Amino-3-methylbutanamido)-3-hydroxybutanoic acid	Amino Acid Derivatives	Others
(2S,3R)-2-((S)-2-Amino-3-methylbutanamido)-3-hydroxybutanoic acid is a threonine derivative ^[1].

HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate ^[1].

HY-P5419

WAAG-3R	Peptides	Others
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.)

HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity ^[1].

HY-P5419A

WAAG-3R TFA	Peptides	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) assay. Ex/Em = 340/420 nm.) ^[1].

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes ^[1] .

HY-P4429

Z-YVAD-AFC

Peptides Others

Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 ^[1].
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor ^[1].
HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity ^[1].
HY-P4547

Ac-Trp-Glu-His-Asp-AMC

AC-WEHD-AMC
Caspase Others

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].
HY-P2377

Ac-YVAD-AFC

Fluorescent Dye Others

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde

Caspase Inflammation/Immunology

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a K_i value of 56 pM ^[1] .
HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA

Cholinesterase (ChE) Caspase Others

Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages ^[1] .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia ^[1].

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ ^[1] ^[3].

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate ^[1].

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis ^[1] .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes ^[1].

HY-P1009

Z-YVAD-FMK Maximum Cited Publications 13 Publications Verification	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities ^[1].

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice ^[1].

HY-60256

(R)-Pyrrolidine-3-carboxylic acid

Amino Acid Derivatives Others

(R)-Pyrrolidine-3-carboxylic acid is a proline derivative ^[1].
HY-20861

(R)-2-amino-3-cyclobutylpropanoic acid

Amino Acid Derivatives Others

(R)-2-amino-3-cyclobutylpropanoic acid is an alanine derivative ^[1].
HY-60040

(R)-2-amino-3-cyclohexylpropanoic acid

Amino Acid Derivatives Others

(R)-2-amino-3-cyclohexylpropanoic acid is an alanine derivative ^[1].

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating Hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an *MC3R* and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R ^[1].

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na ⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-W016547

(R)-2-Amino-3-(m-tolyl)propanoic acid

Amino Acid Derivatives Others

(R)-2-Amino-3-(m-tolyl)propanoic acid is a phenylalanine derivative ^[1].

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) ^[1].

HY-W008178

(R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid	Amino Acid Derivatives	Others
(R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid is a cysteine derivative ^[1].

HY-W022593

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid	Amino Acid Derivatives	Others
(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid is a valine derivative ^[1].

HY-79676

Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate

Amino Acid Derivatives Others

Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate is an alanine derivative ^[1].

HY-W016035

(R)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid	Amino Acid Derivatives	Others
(R)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a phenylalanine derivative ^[1].

HY-P4156

VLVNTFCDSCIPKTYWNLGY TFA	mAChR	Neurological Disease
VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of M3 muscarinic receptor (M3R). VLVNTFCDSCIPKTYWNLGY TFA can be used in ELISA ^[1].

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-W017254

(R)-2-Amino-2-(thiophen-3-yl)acetic acid

Amino Acid Derivatives Others

(R)-2-Amino-2-(thiophen-3-yl)acetic acid is a Glycine (HY-Y0966) derivative ^[1].

HY-W011001

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid	Amino Acid Derivatives	Others
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-cyclohexylpropanoic acid is an alanine derivative ^[1].

HY-W013163

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid	Amino Acid Derivatives	Others
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid is a phenylalanine derivative ^[1].

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 ^[1].

HY-18678A

Bremelanotide Acetate 1 Publications Verification PT-141 Acetate	Melanocortin Receptor	Endocrinology
Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction ^[1].

HY-W011003

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid	Amino Acid Derivatives	Others
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid is an alanine derivative ^[1].

HY-W011019

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid	Amino Acid Derivatives	Others
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid is an alanine derivative ^[1].

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect ^[1].

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect ^[1].

HY-P10166

MLCK Peptide, control	Peptides	Others
MLCK Peptide, control is a myosin light-chain kinase. Adding MLCK peptide to permeabilized L15 cells dramatically decreased IICR. MLCK peptide caused a reduction in the extent of IICR with no change in the affinity of IP3 for the IP3R ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99004

hMC1R agonist 1	Melanocortin Receptor	Inflammation/Immunology
(EC₅₀=3 nM). hMC1R agonist 1 shows at least 300-fold selectivity for *hMC1R* over *hMC3R* (b>EC₅₀=902 nM), hMC4R (b>EC₅₀=915 nM), and hMC5R (b>EC₅₀=>1000 nM). hMC1R agonist 1 has the potential for the therapeutic intervention of melanocortin family ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Source classification Phenols Polyphenols Agavaceae Plants	Phosphatase
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research ^[1].

HY-133872

[(3R)-3-Hydroxydodecanoyl]-L-carnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite ^[1].

HY-122938

Ceplignan (2S,3r)-Ceplignan	Structural Classification Araceae Source classification Acorus gramineus Soland. Phenols Plants	Others
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan ^[1].

HY-N8186

(3R)-7,4’-Dihydrohomoisoflavanone	Infection Flavonoids Dracaena cambodiana Pierre ex Gagnep. Classification of Application Fields Flavonones Source classification Phenols Polyphenols Agavaceae Plants Disease Research Fields	Bacterial
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against *S. aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)** ^[1].

HY-N10862

(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan	Structural Classification Flavonoids Dracaena draco (L.) L. Source classification Agavaceae Plants Other Flavonoids	Others
(3R)-6,4'-Dihydroxy-8-methoxyhomoisoflavan is a natural product that can be isolated from the red resin of Dracaena cochinchinensis ^[1].

HY-W015954

(2R,3R)-Butane-2,3-diol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(2R,3R)-Butane-2,3-diol is an endogenous metabolite.

HY-W010271

(2S,3R,4S)-4-Hydroxyisoleucine (2S,3r,4S)-4-Hydroxy-L-isoleucine; Hydroxyisoleucine	Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields Trigonella foenum-graecum Linn.	Others
(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity ^[1].

HY-108059

β-Cryptoxanthin (3r)-β-Cryptoxanthin	Other Terpenoids Structural Classification Capsicum annuum L. other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Solanaceae Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect ^[1].

HY-W021425

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite.

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Zingiberaceae	Others
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities ^[1].

HY-N11163

(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate	Structural Classification Terpenoids Source classification Diterpenoids Plants Compositae Solidago virgaurea L.	Others
(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate (compound 7a) is a clerodane diterpene ^[1].

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N0619

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM ^[3].

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells ^[1].

HY-W015851

(R)-3-Hydroxybutanoic acid sodium 3 Publications Verification (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones ^[1] .

HY-N1093

(-)-Vestitol (3r)-Vestitol	Structural Classification Glycyrrhiza pallidiflora Maxim. Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Plants Disease Research Fields	Others
(-)-Vestitol is a compound isolated from Glycyrrhiza pallidiflora (Leguminosae) ^[1].

HY-N0816

Polyphyllin VI 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] ^[3].

HY-N6037

Gardenin B 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rubiaceae Phenols Plants Gardenia jasminoides Ellis Disease Research Fields Cancer	Apoptosis
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-W051723

(R)-3-Hydroxybutanoic acid 3 Publications Verification (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid	Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones ^[1] .

HY-N10405

(R)-5-Hydroxy-1,7-diphenyl-3-heptanone	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae	Keap1-Nrf2
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway ^[1].

HY-N0530

Dryocrassin ABBA Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-I1060

L-Alloisoleucine 1 Publications Verification (3r)-LS-Isoleucine; L-Allo-isoleucine	Immune System Disorder Classification of Application Fields Source classification Other Diseases Disease markers Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-122928

Rosamultic acid	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Rosa multifoloraThunb	Apoptosis Caspase
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of *caspases* .

HY-N10837

rel-3R-Methoxy-4S-furanogermacra-1E,10(15)-dien-6-one	Structural Classification Commiphora myrrha (Nees) Engl. Terpenoids Sesquiterpenes Source classification Plants Burseraceae	Others
rel-3-Methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one (compound 4) is a natural product that can be found in Commiphora erythraea ^[1].

HY-103312

Xestospongin C 2 Publications Verification (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Structural Classification Animals Source classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells ^[1] ^[3].

Species:	Human (19) Mouse (4) Cynomolgus (1) Canine (2)
Tag:	His (16) SUMO (2) Tag Free (2) Avi (2) Myc (1) GST (3) Fc (6)
Source:	HEK293 (17) Sf9 insect cells (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P72117

	Caspase-1/CASP1 Protein, Human (GST) CASP-1; CASP1; CASP1_HUMAN; caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (GST) is the recombinant human-derived Caspase-1/CASP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of Caspase-1/CASP1 Protein, Human (GST) is 150 a.a., with molecular weight of ~43.8 kDa.

HY-P77697

	IGFBP-3R Protein, Mouse (HEK293, Fc) IGFBP-3r; GFBP3r; LOC124446; TMEM219	Mouse	HEK293
	The IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and becomes a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This receptor actively interacts with IGFBP3, forming a key molecular connection that may initiate the apoptotic signaling cascade. IGFBP-3R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFBP-3R Protein, Mouse (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

HY-P77962

	TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) IGFBP-3r; GFBP3r; LOC124446; TMEM219	Human	HEK293
	The TMEM219/IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This protein actively binds to IGFBP3, forming a key molecular interaction that may initiate the apoptosis signaling pathway. TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is the recombinant human-derived TMEM219/IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

HY-P700747

	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) CD123; IL-3r subunit alpha; IL3r; IL3rA; IL-3ra; IL3rAY; IL3rX; IL3rY; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi) is 287 a.a., with molecular weight of 55-65 kDa.

HY-P70461

	IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3r subunit alpha; IL-3r-alpha; IL-3rA; CD123	Cynomolgus	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Cynomolgus (HEK293, His) is 285 a.a., with molecular weight of 50-65 kDa.

HY-P70468

	IL-3R alpha/CD123 Protein, Human (HEK293, His) Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3r subunit alpha; IL-3r-alpha; IL-3rA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Human (HEK293, His) is 287 a.a., with molecular weight of 40-60 kDa.

HY-P72349

	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3r subunitalpha; IL-3r-alpha; IL-3rA; CD123	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 287 a.a., with molecular weight of 80-100 kDa.

HY-P701285

	FITC-Labeled IL-3R alpha/CD123 Protein, Human (HEK293, His) IL3r; IL3rA; IL-3ra; IL-3r-alpha; IL3rAY; IL3rX; IL3rY; CD123 antigen; CD123; hIL3ra; hIL-3ra; MGC34174; IL-3 R alpha	Human	HEK293
	FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. FITC-Labeled IL-3R alpha/CD123 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled IL-3R alpha/CD123 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled IL-3R alpha/CD123 Protein, Human (HEK293, His) is 287 a.a., with molecular weight of 50-60 kDa.

HY-P78634

	IL-3R alpha/CD123 Protein, Canine (283a.a, HEK293, His) IL3r; IL3rA; IL-3ra; IL-3r-alpha; IL3rAY; IL3rX; IL3rY; CD123 antigen; CD123; hIL3ra; hIL-3ra; MGC34174; IL-3 R alpha	Canine	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Canine (283a.a, HEK293, His) is the recombinant canine-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Canine (283a.a, HEK293, His) is 283 a.a., with molecular weight of 42-50 kDa.

HY-P75862

	IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) Interleukin-3 receptor subunit alpha; IL-3r-alpha; IL-3rA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation. Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K. This activation leads to cell proliferation and differentiation, mediated by STAT5. IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development. IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-3R alpha/CD123 Protein, Mouse (HEK293, Fc) is 331 a.a., with molecular weight of ~61.5 kDa.

HY-P77008

	IL-3R alpha/CD123 Protein, Canine (299a.a, HEK293, His) Interleukin-3 receptor subunit alpha; IL-3r-alpha; IL-3rA; CD123	Canine	HEK293
	IL-3R α/CD123 protein is an important member of the type I cytokine receptor family and mediates cellular responses to a variety of cytokines, emphasizing its key role in hematopoiesis and immune regulation. IL-3R alpha/CD123 Protein, Canine (299a.a, HEK293, His) is the recombinant canine-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-3R alpha/CD123 Protein, Canine (299a.a, HEK293, His) is 299 a.a., with molecular weight of ~44 kDa.

HY-P72542

	IL-3R alpha/CD123 Protein, Mouse (315a.a, HEK293, His) Interleukin-3 receptor subunit alpha; IL-3r-alpha; IL-3rA; CD123; Sut-1	Mouse	HEK293
	IL-3R alpha/CD123 protein, a receptor for IL3, is expressed on hematopoietic cells and governs their production and differentiation. Upon ligand binding, it heterodimerizes with IL3RB, activating JAK2 and PI3K. This activation leads to cell proliferation and differentiation, mediated by STAT5. IL-3R alpha interacts with IL3 and forms heterodimers with alpha and beta subunits, contributing to hematopoietic cell development. IL-3R alpha/CD123 Protein, Mouse (315a.a, HEK293, His) is the recombinant mouse-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-8*His labeled tag. The total length of IL-3R alpha/CD123 Protein, Mouse (315a.a, HEK293, His) is 315 a.a., with molecular weight of 50-65 kDa.

HY-P7705

	Calcineurin B Protein, Human (His) rHuCNB, His; Calcineurin Subunit B Type 1; PPP3r1; CNB	Human	E. coli
	Calcineurin B Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Calcineurin Subunit B Type 1 is an anti-tumor factor.

HY-P73618

	Tau/0N3R Protein, Human (351a.a, His) MAPT; Mtapt; Tau; Microtubule-associated protein tau; PHF-tau	Human	E. coli
	Tau/0N3R protein is encoded by the Tau/0N3R gene and undergoes regulated alternative splicing to produce different mRNA species. Its expression varies in the nervous system according to the maturation and type of neurons. Tau/0N3R Protein, Human (351a.a, His) is the recombinant human-derived Tau/0N3R protein, expressed by E. coli , with N-His labeled tag. The total length of Tau/0N3R Protein, Human (351a.a, His) is 351 a.a., with molecular weight of 40-50 kDa.

HY-P75692

	G-CSFR/CD114 Protein, Human (HEK293) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3r; GCSFR	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with tag free. The total length of G-CSFR/CD114 Protein, Human (HEK293) is 597 a.a., with molecular weight of ~85.36 kDa.

HY-P72634

	G-CSFR/CD114 Protein, Human (HEK293, Fc) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3r; GCSFR	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, Fc) is 603 a.a., with molecular weight of ~110.17 kDa.

HY-P75694

	G-CSFR/CD114 Protein, Human (HEK293, His) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3r; GCSFR	Human	HEK293
	The G-CSFR/CD114 Protein, acting as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocytic maturation, playing a pivotal role in the proliferation, differentiation, and survival of neutrophilic lineage cells. Additionally, it may participate in cell surface adhesion or recognition events. The homodimeric receptor binds two CSF3 molecules and interacts with CEACAM1, which down-regulates the CSF3R-STAT3 pathway through the recruitment of PTPN6, leading to the dephosphorylation of CSF3R. G-CSFR/CD114 Protein, Human (HEK293, His) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293, with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, His) is 603 a.a., with molecular weight of 90-110 kDa.

HY-P701153

	EBP50 (SLC9A3R1) Recombinant Protein,Human(HEK293,C-His) EBP50; NHERF; NHERF-1; NHERF1; NPHLOP2	Human	HEK293
	EBP50 is a scaffolding protein that connects plasma membrane proteins to the actin cytoskeleton, regulates its surface expression and forms homo- or heterodimers with NHERF2. It regulates the activity and localization of SLC9A3 and is critical for the recycling of ADRB2. EBP50 (SLC9A3R1) Recombinant Protein,Human (HEK293,C-His) is the recombinant human-derived EBP50, expressed by HEK293 , with labeled tag. The total length of EBP50 (SLC9A3R1) Recombinant Protein,Human (HEK293,C-His) is 358 a.a., with molecular weight of ~45-60 kDa.

HY-P700725

	G-CSFR/CD114 Protein, Mouse (HEK293, His) G-CSF-R; G-CSF R; CD114; G CSF R; CSF3r; Csfgr; GCSFR	Mouse	HEK293
	G-CSFR/CD114 Protein, functioning as the receptor for granulocyte colony-stimulating factor (CSF3), plays a pivotal role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules, transducing signals. G-CSFR/CD114's interaction with CEACAM1 down-regulates the CSF3R-STAT3 pathway, recruiting PTPN6 for dephosphorylation, revealing regulatory roles in modulating granulocyte colony-stimulating factor responses. These interactions emphasize G-CSFR/CD114's intricate regulatory involvement in immune responses and hematopoiesis. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293, with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Mouse (HEK293, His) is 601 a.a., with molecular weight of 90-110 kDa.

HY-P701744

	PIK3R3 Protein, Human (Sf9, His, GST) PIK3r3; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK	Human	Sf9 insect cells
	PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (Sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PIK3R3 Protein, Human (Sf9, His, GST) is 460 a.a., .

HY-P701623

	KDM8 Protein, Human KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3r)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human is the recombinant human-derived KDM8 protein, expressed by E. coli , with tag free. The total length of KDM8 Protein, Human is 234 a.a., .

HY-P701624

	KDM8 Protein, Human (His) KDM8; Bifunctional peptidase and arginyl-hydroxylase JMJD5; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3r)-hydroxylase KDM8	Human	E. coli
	The KDM8 protein is a multifunctional enzyme that acts as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. As an endopeptidase, it cleaves histone tails at methylated arginine or lysine residues, producing "tailless nucleosomes" that facilitate transcription elongation. KDM8 Protein, Human (His) is the recombinant human-derived KDM8 protein, expressed by E. coli , with N-6*His labeled tag. The total length of KDM8 Protein, Human (His) is 234 a.a., .

HY-P70557

	RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) R-spondin-3; RSPO3; Protein with TSP type-1 repeat; Roof plate-specific spondin-3; Thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3, a potent activator of the canonical Wnt pathway, binds to LGR4-6 receptors, initiating a complex with phosphorylated LRP6 and frizzled receptors. This interaction activates the canonical Wnt pathway, upregulating target genes. RSPO3, a multifaceted regulator, inhibits ZNRF3 and acts as a ligand for FZD8 and LRP6, potentially negatively regulating the TGF-beta pathway. In angiogenesis, RSPO3 controls vascular stability and pruning through the non-canonical Wnt pathway in endothelial cells. Notably, RSPO3 can amplify the Wnt pathway independently of LGR4-6 receptors, possibly by antagonizing RNF43 and ZNRF3. Interactions with FZD8, LRP6, WNT1, and LGR4-6 underscore its intricate role in Wnt signaling modulation. RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) is the recombinant human-derived RSPO3/R-spondin-3 protein, expressed by HEK293, with C-hFc, C-6*His labeled tag. The total length of RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) is 180 a.a., with molecular weight of ~61.0 kDa.

HY-P72159

	CXCR4 Protein, Human (N-His-SUMO, C-Myc) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3rR; LAP 3; LAP3; LCR1; LESTR; NPY3r; NPYR; NPYRL; NPYY3; NPYY3r; SDF 1 receptor; SDF-1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (N-His-SUMO, C-Myc) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of CXCR4 Protein, Human (N-His-SUMO, C-Myc) is 50 a.a., with molecular weight of ~28 kDa.

HY-P72160

	CXCR4 Protein, Human (GST) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3rR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3r; NPYR; NPYRL; NPYY3; NPYY3r; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag. The total length of CXCR4 Protein, Human (GST) is 50 a.a., with molecular weight of ~32.6 kDa.

HY-P74327A

	CD1D Protein, Human (His-SUMO) Antigen-presenting glycoprotein CD1d; CD1.1; CD1A; CD1d; CD1D antigen; CD1D antigen d polypeptide; CD1d molecule; CD1D_HUMAN; Cd1d1 ; differentiation antigen CD1 alpha 3 ; HMC class I antigen like glycoprotein CD1D ; Ly 38; MGC34622; R3; R3G1; T cell surface glycoprotein CD1d ; Thymocyte antigen CD1D	Human	E. coli

Cat. No.	Product Name	Chemical Structure

HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium

(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium[1].
HY-W012864S1

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
HY-W012864S2

(2S,3R)-2,3,4-Trihydroxybutanal-13C-2

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-2 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].
HY-W012864S

(2S,3R)-2,3,4-Trihydroxybutanal-13C

(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C is the ¹³C labeled N-acetyl-D-talosamine[1].

HY-Z1430S

(3R,4S)-Paroxetine-d4 hydrochloride
Paroxetine EP impurity D-d₄ (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity）.

HY-W242887S2

D-Gulose-13C

D-Gulose- ¹³C is the ¹³C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal[1].
HY-W242887S3

D-Gulose-1-13C

D-Gulose-1- ¹³C is the ¹³C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal[1].

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-W015851S

(R)-3-Hydroxybutanoic acid-13c sodium

(R)-3-Hydroxybutanoic acid- ¹³C (sodium) is the ¹³C labeled (R)-3-Hydroxybutanoic acid sodium[1]. (R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[2][3].

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₂ (sodium) is the ¹³C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2][3].

HY-W015851S2

(R)-3-Hydroxybutanoic acid-13C4 sodium

(R)-3-Hydroxybutanoic acid-13C4 (sodium) is an active compound. (R)-3-Hydroxybutanoic acid-13C4 (sodium) can be used for kinds of research.

HY-146821S

2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate-d7 sodium
2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate-d₇ (sodium) is deuterium labeled 2,3-Dihydroxypropyl ((R)-2-(oleoyloxy)-3-(pentadecanoyloxy)propyl) phosphate (sodium).

HY-W097197S

(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d5
(R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid-d₅ is deuterium labeled (R)-2-((R)-2-Amino-3-phenylpropanamido)-3-phenylpropanoic acid.

HY-A0021AS

(S,R)-Palonosetron-d3 hydrochloride

(S,R)-Palonosetron-d₃ (hydrochloride) is the deuterium labeled (S,R)-Palonosetron hydrochloride[1].

HY-W401531S

(R)-3-O-Methyldopa-d3
(R)-3-O-Methyldopa-d₃ is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine[1][2].

HY-W401531S1

(R)-3-O-Methyldopa-d3 hydrochloride
(R)-3-O-Methyldopa-d₃ (hydrochloride) is a deuterium labeled (R)-3-O-Methyldopa, and (R)-3-O-Methyldopa is an R-enantiomer of 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of L-DOPA and dopamine[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P81232

Caspase-1 p20 Antibody caspase-1 isoform alpha p20 subunit; CASP1; ICE; IL1BC; caspase-1 subunit p20; CASP 1; caspase 1 apoptosis related cysteine peptidase; caspase 1 apoptosis related cysteine protease; caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat,
Caspase-1 p20 Antibody is an unconjugated, approximately 20/46 kDa, rabbit-derived, anti-Caspase-1 p20 polyclonal antibody. Caspase-1 p20 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P80587

Caspase 1 Antibody CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, IHC-P, ELISA	Human, Mouse, Rat
Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Caspase 1. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80622

*Cleaved-Caspase 1* Antibody** CASP1; IL1BC; IL1BCE; caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, ICC/IF, IHC-F, IHC-P, ELISA	Human, Mouse
Cleaved-Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Cleaved-Caspase 1. It can be used for WB,ICC/IF,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse.

HY-P82287

Somatostatin Receptor 3 Antibody (YA2032)

SS3r; SS3-R; SS-3-R; SSR-28
WB Human
HY-P81851

IP3 Receptor Antibody (YA1596)

5-trisphosphate receptor; Inositol 1; InsP3r1; IP3; IP3 receptor; IP3r 1; IP3r; IP3r1; Itpr1; SCA15; SCA16; SCA29
WB Human, Mouse, Rat
HY-P81713

CD123 Antibody (YA1458)

IL3rA; IL3r; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3r subunit alpha; IL-3r-alpha; IL-3rA; CD123
FC, ELISA Human
HY-P82956

HRH3 Antibody (YA2701)

HRH3; GPCR97; Histamine H3 receptor; H3r; HH3r; G-protein coupled receptor 97
WB, ICC/IF, FC Human, Mouse, Rat
HY-P83335

MRAS Antibody (YA3080)

NS11; M-RAs; RRAS3; R-RAS3
WB, IP Human, Mouse, Rat
HY-P83457

EBP50 Antibody (YA3202)

SLC9A3r1; EBP50; NPHLOP2; NHERF; NHERF-1; NHERF1
WB, IHC-P Human, Rat
HY-P81686

CD114 Antibody (YA1431)

CSF3r; GCSFR; Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD114
FC, ELISA Human
HY-P83628

G-CSF Receptor Antibody (YA3373)

CSF3r; GCSFR; Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD114
WB, FC Human
HY-P83078

PI 3 Kinase p150 Antibody (YA2823)

P150; Phosphoinositide 3 kinase regulatory subunit 4; PI3 kinase p150 subunit; PIK3r4; VPS15
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P80867

PI3 Kinase p85 alpha Antibody (YA689) PIK3r1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, IHC-P	Human, Mouse, Rat
PI3 Kinase p85 alpha Antibody (YA689) is a non-conjugated and Mouse origined monoclonal antibody about 84 kDa, targeting to PI3 Kinase p85 alpha (1C8). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80846

Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody 1 Publications Verification PIK3r1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 84 kDa, targeting to Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199). It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat, Monkey.

Cat. No.	Product Name		Classification

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151663

Fmoc-Abu(3-N3) (2R,3R) Fmoc-Abu(3-N3)-OH (2R,3r)		Azide
Fmoc-Abu(3-N3) (Fmoc-Abu(3-N3)-OH) (2R,3R) is a click chemistry reagent containing an azide group. Fmoc-Abu(3-N3) (2R,3R) can be used for the research of various biochemical ^[1].

HY-151689

(2S,3R)-Fmoc-Abu(3-N3)-OH		Azide
(2S,3R)-Fmoc-Abu(3-N3)-OH is a click chemistry reagent containing an azide group. (2S,3R)-Fmoc-Abu(3-N3)-OH can be used for the research of various biochemical ^[1].

HY-151836

(2S,3R)-H-Abu(3-N3)-OH hydrochloride		Azide
(2S,3R)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group ^[1]. (2S,3R)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate ^[1]. (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM ^[1]. (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-10444

R-1479 3 Publications Verification 4'-Azidocytidine		Azide
R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC₅₀=1.28 μM) ^[1] ^[3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.


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