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Results for "

caspase-dependent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (5) ADC Cytotoxin (1) Antibiotic (1) Apoptosis (19) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (3) Bacterial (1) Bcl-2 Family (1) Btk (1) Endogenous Metabolite (1) ERK (1) HDAC (2) Influenza Virus (1) Integrin (1) Isotope-Labeled Compounds (1) JNK (1) Lipoxygenase (1) MAP4K (1) MDM-2/p53 (1) MEK (1) Mitochondrial Metabolism (1) Molecular Glues (1) P-glycoprotein (2) p38 MAPK (1) p62 (1) Phosphatase (1) PKC (1) PROTACs (1) Proteasome (1) Reactive Oxygen Species (1) Ribosomal S6 Kinase (RSK) (1) ROR (1) Wnt (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (5) Metabolic Disease (1)

By Targets:

Caspase (5)

ADC Cytotoxin (1)

Antibiotic (1)

Apoptosis (19)

Atg8/LC3 (1)

Aurora Kinase (1)

Autophagy (3)

Bacterial (1)

Bcl-2 Family (1)

Btk (1)

Endogenous Metabolite (1)

ERK (1)

HDAC (2)

Influenza Virus (1)

Integrin (1)

Isotope-Labeled Compounds (1)

JNK (1)

Lipoxygenase (1)

MAP4K (1)

MDM-2/p53 (1)

MEK (1)

Mitochondrial Metabolism (1)

Molecular Glues (1)

P-glycoprotein (2)

p38 MAPK (1)

p62 (1)

Phosphatase (1)

PKC (1)

PROTACs (1)

Proteasome (1)

Reactive Oxygen Species (1)

Ribosomal S6 Kinase (RSK) (1)

ROR (1)

Wnt (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (5)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Caspase Apical Sodium-Dependent Bile Acid Transporter CaMK CDK SNIPERs DNA-PK VDAC SGLT PDK-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121320

Raptinal 3 Publications Verification	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates *caspase-3, initiates intrinsic pathway caspase-dependent* apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9 .

HY-59001

Sappanchalcone

Apoptosis Cancer

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

Sappanchalcone	Apoptosis	Cancer
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

HY-14804

Tasisulam LY 573636	Molecular Glues Apoptosis	Cancer
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization .

HY-131143

Cadein1

Apoptosis Cancer

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53 .

Cadein1	Apoptosis	Cancer
Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53 .

HY-14804A

Tasisulam sodium LY 573636 sodium	Apoptosis	Cancer
Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic progression and induces vascular normalization .

HY-149208

HDAC-IN-53	HDAC Apoptosis	Cancer
HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC₅₀ values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9; IC₅₀>10 μM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer .

HY-146037

Aurora A inhibitor 2	Apoptosis Aurora Kinase	Cancer
Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC₅₀ of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells .

HY-N10491

Spongionellol A	P-glycoprotein	Cancer
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N3354

Lupiwighteone 8-prenylgenistein	Apoptosis	Cancer
Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway .

HY-N2602

Sanggenol L	MDM-2/p53	Cancer
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-120035

DD1	Proteasome Ribosomal S6 Kinase (RSK) Apoptosis	Cancer
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .

HY-18712

BG45 2 Publications Verification	HDAC Apoptosis Caspase	Cancer
BG45 is a potent HDAC3 inhibitor with IC₅₀ values of 0.289, 2, 2.2 and ﹥20 μM for HDAC3, HDAC1, HDAC2 and HDAC6, respectively. BG45 selectively targets multiple myeloma (MM) cells and induces caspase-dependent apoptosis .

HY-N10492

Spongionellol A analog 1	P-glycoprotein	Cancer
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-122534

Mensacarcin	Mitochondrial Metabolism ADC Cytotoxin Apoptosis	Cancer
Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .

HY-N6801

Nivalenol	Caspase Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through *caspase*-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-N2369

Chelidonine	Apoptosis Influenza Virus	Infection Cancer
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-101448

TMI-1 WAY-171318
TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood . TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Phosphatase Apoptosis Autophagy	Inflammation/Immunology Cancer
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-117800

BJE6-106 1 Publications Verification B106	PKC Apoptosis	Inflammation/Immunology Cancer
BJE6-106 (B106) is a potent, selective 3 ^rd generation PKCδ inhibitor with an IC₅₀ of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC₅₀=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.

HY-155542

RORγ antagonist 1	ROR	Cancer
RORγ antagonist 1 (compound 22), a potent betulinic acid derivative, is an antagonist of RORγ (K_D=0.18 μM). RORγ antagonist 1 exhibits anti-proliferative activity in HPAF-II pancreatic cancer xenograft model. RORγ antagonist 1 inhibits RAS/MAPK and AKT/mTORC1 pathway, and induces caspase-dependent apoptosis in pancreatic cancer cells .

HY-N0551

Wedelolactone Maximum Cited Publications 14 Publications Verification	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone suppresses LPS-induced *caspase-11* expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N6801S

Nivalenol-13C15	Isotope-Labeled Compounds	Infection
Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through *caspase*-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-100423

Eltanexor 1 Publications Verification KPT-8602
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC₅₀=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines .

HY-154860

PTD10	PROTACs Btk	Cancer
PTD10 is a highly potent PROTAC BTK degrader (DC₅₀: 0.5 nM, K_D: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC₅₀s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation .

HY-108635

C16-PAF 5+ Cited Publications PAF (C16)	p38 MAPK MEK ERK Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-18676

OSU-T315 5+ Cited Publications	Integrin Autophagy Apoptosis	Cancer
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC₅₀ of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-124745

KY-05009	MAP4K Wnt Apoptosis	Cancer
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a K_i of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity .

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-59001

Sappanchalcone	Flavonoids Chalcones Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells .

HY-N3354

Lupiwighteone 8-prenylgenistein	Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Apoptosis
Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway .

HY-N10491

Spongionellol A	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N2602

Sanggenol L	Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-N10492

Spongionellol A analog 1	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-N6801

Nivalenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Inflammation/Immunology Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through *caspase*-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-N2369

Chelidonine	Infection Alkaloids Structural Classification Classification of Application Fields Chelidonium majus Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Apoptosis Influenza Virus
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-N0551

Wedelolactone 10+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced *caspase-11* expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-108635

C16-PAF 5+ Cited Publications PAF (C16)	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	p38 MAPK MEK ERK Endogenous Metabolite
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-P3148

Astin B	Structural Classification Alkaloids Other Alkaloids Source classification Plants Compositae Erythrina latissima E. Mey.	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

Cat. No.	Product Name	Chemical Structure

HY-N6801S

Nivalenol-13C15
Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through *caspase*-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

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