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Results for "

cav1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Angiotensin Receptor (1) Apoptosis (3) Arrestin (1) Bcl-2 Family (1) Calcium Channel (22) Dipeptidyl Peptidase (1) Dopamine Receptor (1) Endogenous Metabolite (1) Histamine Receptor (1) iGluR (1) Integrin (1) Isotope-Labeled Compounds (5) Mineralocorticoid Receptor (1) NO Synthase (2) P-glycoprotein (1) P2Y Receptor (1) p38 MAPK (1) PI3K (1) Potassium Channel (3) PROTACs (1) Reactive Oxygen Species (ROS) (5) Reference Standards (3) Small Interfering RNA (siRNA) (3) Sodium Channel (1) Somatostatin Receptor (1) STAT (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (18) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112499

Menaquinone-7 3 Publications Verification Vitamin K2-7; Vitamin K2(35); Vitamin MK-7	TGF-beta/Smad	Cardiovascular Disease
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-N2488

Demethylsuberosin 4 Publications Verification 7-Demethylsuberosin	Calcium Channel NO Synthase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type Ca_V1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells ^[1] .

HY-134542

CaV1.3 antagonist-1	Calcium Channel	Neurological Disease
CaV1.3 antagonist-1 is a potent and highly selective Ca_V1.3 L-type calcium channel (LTCC) antagonist with an IC₅₀ of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca_V1.3 LTCC >600-fold more potently than Ca_V1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research ^[1].

HY-B1090

Cinnarizine	Calcium Channel Histamine Receptor	Cardiovascular Disease Endocrinology
Cinnarizine is an orally active, effective and selective inhibitor of L-type calcium channel *Cav1.3* with an IC₅₀ of 1.5 μM (in vestibular hair cells). Cinnarizine can cross the blood-brain barrier and regulate calcium homeostasis and dopamine neurotransmission. Cinnarizine inhibits the influx of calcium ions into smooth muscle cells by blocking L-type calcium channels, thereby relaxing vascular smooth muscle, improving cerebral circulation and reducing blood viscosity, while antagonizing dopamine receptors. Cinnarizine can be used in the study of vestibular vertigo, Meniere's disease and cerebrovascular diseases ^[1] .

HY-B1752

Quinpirole 4 Publications Verification LY 171555; (-)-LY 141865	Dopamine Receptor Calcium Channel Bcl-2 Family iGluR Apoptosis	Neurological Disease
Quinpirole (LY 171555; (-)-LY 141865) is a D2/D3 dopamine receptor agonist and a *CaV1.3* calcium channel modulator. Quinpirole normalizes dendritic spine density in dopamine-depleted striatum, upregulates the protein expression of BCL2 and GluR2, downregulates the protein expression of BAX, and delays the onset of seizures. Quinpirole enhances learning and memory, inhibits neuronal apoptosis (apoptosis), and induces anxiety-like, stereotyped, and compulsive behaviors. Quinpirole disrupts prepulse inhibition in rhesus monkeys, enhances the activity of paraventricular thalamic neurons to promote recovery from Isoflurane anesthesia, and alters the composition of the gut microbiota in rats. Quinpirole can be used in research related to dyskinesia, pain, epilepsy, and neurological disorders including anxiety disorder, obsessive-compulsive disorder, and schizophrenia ^[1] .

HY-RS01986

CAV1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAV1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAV1 Human Pre-designed siRNA Set A CAV1 Human Pre-designed siRNA Set A

HY-106454

N-Desalkylflurazepam Norfludiazepam	Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for *Ca_v1.2* and *Ca_v1.3*, respectively ^[1] .

HY-P3269

Calciseptine	Calcium Channel	Cardiovascular Disease
Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the *Cav1.2* subtype, with an IC₅₀ value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases_[1].

HY-RS23990

Cav1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cav1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cav1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cav1 Rat Pre-designed siRNA Set A Cav1 Rat Pre-designed siRNA Set A

HY-Z7760

Felodipine 3,5-dimethyl ester	Mineralocorticoid Receptor	Metabolic Disease
Felodipine 3,5-Dimethyl Ester is a aryldihydropyridine derivatives for use as mineralocorticoid receptor modulator and voltage-dependent L-type calcium channel CaV1.2 inhibitor ^[1].

HY-RS17533

Cav1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cav1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cav1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cav1 Mouse Pre-designed siRNA Set A Cav1 Mouse Pre-designed siRNA Set A

HY-112499R

Menaquinone-7 (Standard) 3 Publications Verification Vitamin K2-7(Standard); Vitamin K2(35)(Standard); Vitamin MK-7 (Standard)	Endogenous Metabolite Reference Standards	Cardiovascular Disease
Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-126336

HM12	Calcium Channel	Cardiovascular Disease Neurological Disease
HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the *Cav1.2* (L-type) and *Cav3.2* (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc ^[1].

HY-175226

DPP8/9-IN-2	Dipeptidyl Peptidase Calcium Channel Sodium Channel Potassium Channel	Cancer
DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC₅₀ values of 0.22 nM and 3 nM, respectively, and K_i values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC₅₀ values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, *Nav1.5* sodium channel and *Cav1.2* calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors ^[1].

HY-Z15823

(R)-Verapamil Dexverapamil	Calcium Channel Potassium Channel Somatostatin Receptor Arrestin Apoptosis P-glycoprotein	Metabolic Disease Inflammation/Immunology
(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Ca_v1.2) (IC₅₀ > 300 μM), and its IC₅₀ for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC₅₀ of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp) ^[1] .

HY-106454R

N-Desalkylflurazepam (Standard) Norfludiazepam (Standard)	Reference Standards Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively ^[1] .

HY-W701464

N-Desalkylflurazepam-d4	Isotope-Labeled Compounds	Others
N-Desalkylflurazepam-d₄ is a deuterated labeled N-Desalkylflurazepam (HY-106454). N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for *Ca_v1.2* and *Ca_v1.3*, respectively ^[1] .

HY-17402S

Nisoldipine-d6 BAY-k 5552-d₆	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-17402R

Nisoldipine (Standard) BAY-k 5552 (Standard)	Reference Standards Calcium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-17402S3

Nisoldipine-d3 BAY-k 5552-d₃	Calcium Channel Reactive Oxygen Species (ROS) Isotope-Labeled Compounds	Cardiovascular Disease
Nisoldipine-d₃ is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-122552

Chrysotobibenzyl	Integrin	Cancer
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) ^[1].

HY-17402S1

Nisoldipine-d4	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nisoldipine-d₄ (BAY-k 5552-d₄) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC₅₀ of 10 nM ^[1] .

HY-17402S2

Nisoldipine-d7	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease
Nisoldipine-d₇ (BAY-k 5552-d₇) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC₅₀ of 10 nM ^[1] .

HY-118202A

(-)-Gallopamil hydrochloride (-)-Methoxyverapamil hydrochloride	Calcium Channel	Cardiovascular Disease
(-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently *Cav1.2* constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics ^[1] .

HY-118202

(-)-Gallopamil (-)-Methoxyverapamil	Calcium Channel	Cardiovascular Disease
(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently *Cav1.2* constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil is promising for research of antiarrhythmics ^[1] .

HY-159090

AT1R antagonist 3	Calcium Channel Angiotensin Receptor	Cardiovascular Disease
AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV_1.2 (IC₅₀=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models ^[1].

HY-116307

2-Thio-UTP	P2Y Receptor	Cardiovascular Disease
2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

HY-146173

KCa1.1 channel activator-1	Potassium Channel Calcium Channel	Cardiovascular Disease
KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular K_Ca1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays Ca_V1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity ^[1].

HY-N4189

Isocucurbitacin B	PI3K Akt p38 MAPK STAT Apoptosis	Cancer
Isocucurbitacin B is a natural terpenoid compound found in Pedicellus Melo. Isocucurbitacin B can inhibit the PI3K/AKT, MAPK, and STAT3 signaling pathways and downregulate *CAV1* expression. Isocucurbitacin B can inhbit cancer cell proliferation, migration and invision. Isocucurbitacin B can induce apoptosis and cause G2/M phase arrest. Isocucurbitacin B can decrease intracellular cholesterol and PH levels and increase intracellular calcium levels. Isocucurbitacin B can be used for the research of cancer, such as glioma ^[1][2].

HY-175395

Onychocin B	Calcium Channel	Cardiovascular Disease
Onychocin B is a cyclic tetrapeptide isolated from Onychocola sclerotica. Onychocin B is a calcium channel blocker with an IC₅₀ of 7.1 μM for Cav1.2 ^[1].

HY-P3269A

Calciseptine TFA	Calcium Channel	Cardiovascular Disease
Calciseptine TFA, a polypeptide found in black mamba venom, is a selcetive *Cav1.2* L-type calcium channel inhibitor with an IC₅₀ of 92 nM. Calciseptine TFA binds to the pore domain shoulder at repeats III and IV of Cav1.2, stabilizing an inactivated conformation. Calciseptine TFA exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the research of cardiovascular diseases ^[1] .

HY-180547

MRC71	PROTACs	Neurological Disease
MRC71 is a TRIMTAC degrader targeting Halo Tag, containing a PEG linker and chloroalkane. MRC71 selectively degrades oligomeric CAV1- and Cavin1-mEGFP-Halo over monomeric mEGFP-Halo and exhibits a characteristic hook effect concentration-dependence for degradation ^[1].

HY-N12859

Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside	Others	Others
Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside is a flavonoid glycoside that can be isolated from Malope trifida Cav .

HY-156889

Cav 3.1 blocker 1	Calcium Channel	Neurological Disease
Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC₅₀value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC₅₀ of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC₅₀ of >10000 nM) ^[1].

HY-181755

Phenylaminojuglone AJ-2	NO Synthase	Inflammation/Immunology
Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, *CaV1.2* calcium channel, KV channel and KCa channel. Phenylaminojuglone AJ-2 blocks extracellular Ca ²⁺ influx, regulates the activity of the NO−sGC−cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm ^[1].

Cat. No.	Product Name

HY-L923

Ion Channel Lead-like Compound Library	9000 compounds
Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields. MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Ion Channel Lead-like Compound Library

9000 compounds

Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields.

MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Cat. No.	Product Name	Target	Research Area

HY-P2288A

WL47 TFA 3 Publications Verification	Peptides	Cancer
WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function ^[1].

HY-P3269

Calciseptine	Calcium Channel	Cardiovascular Disease
Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the *Cav1.2* subtype, with an IC₅₀ value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases_[1].

HY-P2288

WL47	Peptides	Cancer
WL47, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of *CAV1* oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function ^[1].

HY-P10332

WL 47 dimer	Peptides	Others
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of *CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1* function ^[1].

HY-P3269A

Calciseptine TFA	Calcium Channel	Cardiovascular Disease
Calciseptine TFA, a polypeptide found in black mamba venom, is a selcetive *Cav1.2* L-type calcium channel inhibitor with an IC₅₀ of 92 nM. Calciseptine TFA binds to the pore domain shoulder at repeats III and IV of Cav1.2, stabilizing an inactivated conformation. Calciseptine TFA exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the research of cardiovascular diseases ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2488

Demethylsuberosin 4 Publications Verification 7-Demethylsuberosin	Monophenols Classification of Application Fields Coumarins Phenols Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	Calcium Channel NO Synthase
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type Ca_V1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells ^[1] .

HY-122552

Chrysotobibenzyl	Natural Products Orchidaceae Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl. Source Classification	Integrin
Chrysotobibenzyl can be isolated from stem of Dendrobium pulchellum. Chrysotobibenzyl inhibits lung cancer cell (H460 and H292) migration, invasion, filopodia formation via Cav-1, integrins β1, β3, and αν, and EMT suppressions. Chrysotobibenzyl also sensitizes lung cancer cell death mediated by Cisplatin (HY-17394) ^[1].

HY-N4189

Isocucurbitacin B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	PI3K Akt p38 MAPK STAT Apoptosis
Isocucurbitacin B is a natural terpenoid compound found in Pedicellus Melo. Isocucurbitacin B can inhibit the PI3K/AKT, MAPK, and STAT3 signaling pathways and downregulate *CAV1* expression. Isocucurbitacin B can inhbit cancer cell proliferation, migration and invision. Isocucurbitacin B can induce apoptosis and cause G2/M phase arrest. Isocucurbitacin B can decrease intracellular cholesterol and PH levels and increase intracellular calcium levels. Isocucurbitacin B can be used for the research of cancer, such as glioma ^[1][2].

HY-175395

Onychocin B	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Calcium Channel
Onychocin B is a cyclic tetrapeptide isolated from Onychocola sclerotica. Onychocin B is a calcium channel blocker with an IC₅₀ of 7.1 μM for Cav1.2 ^[1].

HY-N12859

Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside	Malvaceae Flavonoids Flavones Malva sinensis Cav. Plants Source Classification	Others
Herbacetin 3-O-glucopyranoside-8-O-glucuronopyranoside is a flavonoid glycoside that can be isolated from Malope trifida Cav .

Species:	Human (1) Pig (1)
Tag:	His (2)
Source:	E. coli Cell-free (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P790063

	*Caveolin-1/CAV1* Protein, Human (Cell-Free, His)** cav1; cav	Human	E. coli Cell-free
	Caveolin-1/CAV1 protein is an important scaffold component in the caveolae membrane, forming a stable complex with CAV2 to guide caveolar formation and lipid raft positioning. It recruits CAVIN proteins (CAVIN1/2/3/4) to caveolae, thereby increasing the complexity of cell signaling. Caveolin-1/CAV1 Protein, Human (Cell-Free, His) is the recombinant human-derived Caveolin-1/CAV1, expressed by E. coli Cell-free, with N-10*His labeled tag.

HY-P702228

	CACNA1C Protein, Pig (Cell-Free, His) Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha cav1.2	Pig	E. coli Cell-free
	The CACNA1C protein is the alpha-1C subunit of voltage-gated calcium channels that generate L-type calcium currents that are critical for calcium influx and sarcoplasmic release. Its role in excitation-contraction coupling is critical for cardiac development, rhythm regulation, and smooth muscle cell contraction. CACNA1C Protein, Pig (Cell-Free, His) is the recombinant pig-derived CACNA1C protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W701464

N-Desalkylflurazepam-d4
N-Desalkylflurazepam-d₄ is a deuterated labeled N-Desalkylflurazepam (HY-106454). N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for *Ca_v1.2* and *Ca_v1.3*, respectively ^[1] .

HY-17402S

Nisoldipine-d6
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-17402S3

Nisoldipine-d3
Nisoldipine-d₃ is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.

HY-17402S1

Nisoldipine-d4
Nisoldipine-d₄ (BAY-k 5552-d₄) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC₅₀ of 10 nM ^[1] .

HY-17402S2

Nisoldipine-d7
Nisoldipine-d₇ (BAY-k 5552-d₇) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC₅₀ of 10 nM ^[1] .

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (1) Mouse (2)
Application:	IHC-P (4) ICC/IF (4) IP (3) IHC-F (2) WB (5) FC (1) ELISA (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82037

	Caveolin-1 Antibody (YA1782) cav1; cav; caveolin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

HY-P86337

	Caveolin-1 Antibody (YA6029) cav1; cav; caveolin-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Caveolin-1 Antibody (YA6029) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

HY-P82037A

	Caveolin-1 Antibody (YA1782)(PBS only) cav1; cav; caveolin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Caveolin-1 Antibody (YA1782) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.

HY-P86255

	CACNA1F Antibody (YA5947) CACNA1F; CACNAF1; Voltage-dependent L-type calcium channel subunit alpha-1F ; Voltage-gated calcium channel subunit alpha cav1.4;	WB, FC	Human
	CACNA1F Antibody (YA5947) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CACNA1F.

HY-P80053

	Caveolin-1 Antibody (YA549) 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse
	Caveolin-1 Antibody (YA549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caveolin-1.