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Isoforms Recommended: CCR2
Results for "

ccr2

" in MedChemExpress (MCE) Product Catalog:

67

Inhibitors & Agonists

3

Peptides

3

Inhibitory Antibodies

1

Natural
Products

3

Recombinant Proteins

4

Antibodies

5

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15418
    RS 504393
    Maximum Cited Publications
    30 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).
    RS 504393
  • HY-14882
    Cenicriviroc
    5+ Cited Publications

    TAK-652; TBR-652

    CCR HIV Infection Endocrinology
    Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity .
    Cenicriviroc
  • HY-50674
    INCB3344
    Maximum Cited Publications
    30 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    INCB3344
  • HY-18611A
    Abaucin
    20+ Cited Publications

    RS102895; MLJS-21001

    CCR Neurological Disease Endocrinology
    RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
    Abaucin
  • HY-12080
    BX471
    20+ Cited Publications

    ZK-811752

    CCR Inflammation/Immunology Endocrinology
    BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
    BX471
  • HY-109593
    BMS-813160
    1 Publications Verification

    CCR Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC50s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation [2].
    BMS-813160
  • HY-50669
    MK-0812
    1 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2.
    MK-0812
  • HY-13245
    PF-4136309
    5 Publications Verification

    INCB8761

    CCR Inflammation/Immunology Endocrinology
    PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
    PF-4136309
  • HY-101908
    BMS CCR2 22
    1 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM) [2].
    BMS CCR2 22
  • HY-108323
    CCR2 antagonist 4
    5+ Cited Publications

    Teijin compound 1

    CCR Inflammation/Immunology
    CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM .
    CCR2 antagonist 4
  • HY-103362
    CCR2 antagonist 4 hydrochloride
    5+ Cited Publications

    Teijin compound 1 hydrochloride

    CCR Inflammation/Immunology
    CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM .
    CCR2 antagonist 4 hydrochloride
  • HY-14882A
    Cenicriviroc Mesylate
    5+ Cited Publications

    TAK-652 Mesylate; TBR-652 Mesylate

    CCR HIV Infection Inflammation/Immunology Endocrinology
    Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
    Cenicriviroc Mesylate
  • HY-12080A
    BX471 hydrochloride
    20+ Cited Publications

    ZK-811752 hydrochloride

    CCR Inflammation/Immunology Endocrinology
    BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
    BX471 hydrochloride
  • HY-P99781

    MLN-1202

    CCR Inflammation/Immunology Cancer
    Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) [2] .
    Plozalizumab
  • HY-101713
    Ilacirnon
    1 Publications Verification

    CCX140; CCX140-B

    CCR Metabolic Disease Endocrinology
    CCX140 (CCX140-B) is a potent CCR2 antagonist.
    Ilacirnon
  • HY-18611
    Abaucin hydrochloride
    20+ Cited Publications

    RS102895 hydrochloride; MLJS-21001 hydrochloride

    CCR Neurological Disease Endocrinology
    RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
    Abaucin hydrochloride
  • HY-50669A
    MK-0812 Succinate
    1 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.
    MK-0812 Succinate
  • HY-13499

    ccr2 antagonist 5

    CCR Inflammation/Immunology
    JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). JNJ-41443532 displays a Ki of 9.6 µM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease .
    JNJ-41443532
  • HY-101264

    CCR Inflammation/Immunology Endocrinology
    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.
    CCR2 antagonist 3
  • HY-135891

    CCR Neurological Disease
    AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca 2+ flux [2] .
    AZD2423
  • HY-50081
    CCR2-RA-[R]
    4 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
    CCR2-RA-[R]
  • HY-103360
    J-113863
    3 Publications Verification

    CCR Inflammation/Immunology
    J-113863 is a potent and selective CCR1 antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect [2] .
    J-113863
  • HY-19974
    TAK-220
    3 Publications Verification

    CCR HIV Infection Endocrinology
    TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.
    TAK-220
  • HY-112792
    CCR2 antagonist 1
    1 Publications Verification

    CCR Endocrinology
    CCR2 antagonist 1 (compound 15a) is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM .
    CCR2 antagonist 1
  • HY-110132

    CCR Inflammation/Immunology
    JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2 .
    JNJ-27141491
  • HY-117621

    CCR Metabolic Disease
    PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy .
    PF-04634817
  • HY-117621A

    CCR Metabolic Disease
    PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 succinate is safe and well-tolerated and has the potential for the study of diabetic nephropathy .
    PF-04634817 succinate
  • HY-15450A
    INCB 3284
    2 Publications Verification

    CCR Endocrinology
    INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.
    INCB 3284
  • HY-112874

    BMS-687681

    CCR Neurological Disease Inflammation/Immunology Cancer
    BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7. TM7 and TM6 are the main components of the orthosteric binding site. BMS-681 can be used to study inflammatory neurodegenerative diseases and cancer .
    BMS-681
  • HY-RS02151

    Small Interfering RNA (siRNA) CCR Others

    CCR2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CCR2 Human Pre-designed siRNA Set A
    CCR2 Human Pre-designed siRNA Set A
  • HY-174746

    mRNA Inflammation/Immunology
    Human CCR2 mRNA encodes the human C-C motif chemokine receptor 2 (CCR2) protein, a chemokine which specifically mediates monocyte chemotaxis. CCR2 can mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.
    Human CCR2 mRNA
  • HY-RS02152

    Small Interfering RNA (siRNA) CCR Others

    Ccr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ccr2 Mouse Pre-designed siRNA Set A
    Ccr2 Mouse Pre-designed siRNA Set A
  • HY-RS02153

    Small Interfering RNA (siRNA) CCR Others

    Ccr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ccr2 Rat Pre-designed siRNA Set A
    Ccr2 Rat Pre-designed siRNA Set A
  • HY-180572

    Ligands for Target Protein for PROTAC CCR Cancer
    CCR2 ligand-1 is a ligand for CCR2. CCR2 ligand-1 conjugates with the Linker PIN1 degrader-3 (HY-79577) and the E3 ligase ligand Thalidomide 4-fluoride (HY-41547) can be used for the synthesis of LUF7996 (HY-180571) .
    CCR2 ligand-1
  • HY-77111
    cis-INCB3344
    1 Publications Verification

    CCR Drug Isomer Inflammation/Immunology Endocrinology
    cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    cis-INCB3344
  • HY-108432

    CCR Inflammation/Immunology
    BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5 .
    BMS-741672
  • HY-100819

    CCR Metabolic Disease
    RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy .
    RO5234444
  • HY-P11553

    CCR Inflammation/Immunology
    ECL1i is an allosteric, selective CCR2 inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .
    ECL1i
  • HY-185299

    CCR Inflammation/Immunology
    CCR2 antagonist 6 (Example 98) is a CCR2 antagonist (Kb: 0.215 μM for CCR2, 0.174 μM for hCCR2B). CCR2 antagonist 6 can be used in the research of inflammation and autoimmune diseases .
    CCR2 antagonist 6
  • HY-P11553A

    CCR Infection Inflammation/Immunology
    ECL1i TFA is an allosteric, selective CCR2 inhibitor. ECL1i TFA specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i TFA interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .
    ECL1i TFA
  • HY-101908R

    Reference Standards CCR Inflammation/Immunology Endocrinology
    BMS CCR2 22 (Standard) is the analytical standard of BMS CCR2 22 (HY-101908). This product is intended for research and analytical applications. BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM) [2].
    BMS CCR2 22 (Standard)
  • HY-177596

    Cp3C

    CCR Others
    Dicytidine 5′-triphosphate (Cp3C) is a cytosine-containing dinucleoside polyphosphate. Dicytidine 5′-triphosphate inhibits the intracellular accumulation of trans-resveratrol and trans-piceid. Dicytidine 5′-triphosphate induces the expression of CCR2 and upregulates the expression of PAL1 and 4CL1 .
    Dicytidine 5′-triphosphate
  • HY-15418R

    CCR Inflammation/Immunology Endocrinology
    RS 504393 (Standard) is the analytical standard of RS 504393. This product is intended for research and analytical applications. RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).
    RS 504393 (Standard)
  • HY-136768

    CCR Inflammation/Immunology
    YJC-10592 is an orally active CCR-2 antagonist. YJC-10592 binds to HAS. YJC-10592 can be used in the research of asthma and idiopathic dermatitis .
    YJC-10592
  • HY-P991745

    CCR Inflammation/Immunology
    Anti-Mouse CCR2 Antibody (C2Mab-6) is raised against and binds to the N-terminal sequence of CCR2. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
    Anti-Mouse CCR2 Antibody (C2Mab-6)
  • HY-112792A

    CCR Endocrinology
    (1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM .
    (1S)-CCR2 antagonist 1
  • HY-14882R

    TAK-652 (Standard); TBR-652 (Standard)

    CCR HIV Reference Standards Infection Endocrinology
    Cenicriviroc (Standard) is the analytical standard of Cenicriviroc. This product is intended for research and analytical applications. Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity .
    Cenicriviroc (Standard)
  • HY-15450

    CCR Endocrinology
    INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.
    INCB 3284 dimesylate
  • HY-50084

    CCR Cancer
    CCR2-RA is a allosteric antagonist of chemokine (C-C motif) receptor 2 (CCR 2), and it can be used in cancer research .
    CCR2-RA
  • HY-177596A

    Cp3C trisodium

    CCR Others
    Dicytidine 5′-triphosphate (Cp3C) trisodium is a cytosine-containing dinucleoside polyphosphate. Dicytidine 5′-triphosphate trisodium inhibits the intracellular accumulation of trans-resveratrol and trans-piceid. Dicytidine 5′-triphosphate trisodium induces the expression of CCR2 and upregulates the expression of PAL1 and 4CL1 .
    Dicytidine 5′-triphosphate trisodium

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