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chemopreventive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (11) Autophagy (2) Bacterial (2) Beta-secretase (2) COX (2) Cytochrome P450 (1) DNA Methyltransferase (1) EBV (2) Endogenous Metabolite (5) ERK (1) Estrogen Receptor/ERR (1) Glucosidase (2) Insulin Receptor (1) MAP3K (1) MMP (1) mTOR (1) NF-κB (4) Parasite (1) PGE synthase (1) Reactive Oxygen Species (1) SARS-CoV (1) Wnt (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (1) Endocrinology (1) Infection (6) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131991

Benzyl selenocyanate	DNA Methyltransferase	Cancer
Benzyl selenocyanate is a chemopreventive agent for various chemically induced tumors in animal models at both the initiation and postinitiation stages. Benzyl selenocyanate is an inhibitor of DNA (cytosine-5)-methyltransferase (Mtase), with an with an IC₅₀ of 8.4 µM .

HY-N2558

Murrayone	Others	Cancer
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .

HY-N8449

Ailanthoidol	Others	Inflammation/Immunology Cancer
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion .

HY-115772

4′-Bromoflavone

Others Cancer

4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer .

4′-Bromoflavone	Others	Cancer
4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer .

HY-115771

3-Phenylpropyl isothiocyanate	Others	Cancer
3-Phenylpropyl isothiocyanate has a stronger inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis. 3-Phenylpropyl isothiocyanate has chemopreventive effects .

HY-126379

CDDO-2P-Im	Apoptosis	Cancer
CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model .

HY-N10013

β-Damascone	Others	Others
β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide .

HY-126067

(-)-Pinoresinol	Glucosidase Apoptosis	Inflammation/Immunology
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

HY-114245

Se-Methylselenocysteine 2 Publications Verification Methylselenocysteine; Se-Methylseleno-L-cysteine	Apoptosis Endogenous Metabolite Beta-secretase	Cancer
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis .

HY-114245B

Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride	Endogenous Metabolite Apoptosis Beta-secretase	Cancer
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis .

HY-135953

CDDO-3P-Im	Apoptosis	Cancer
CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model . CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R) .

HY-B1000A

L-SelenoMethionine 1 Publications Verification	Endogenous Metabolite Apoptosis	Cancer
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

HY-N10754

Aschantin	mTOR Cytochrome P450	Infection Cardiovascular Disease Cancer
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .

HY-N7073

Silymarin 4 Publications Verification	SARS-CoV	Infection Neurological Disease Inflammation/Immunology Cancer
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (M ^pro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

HY-14933

Prinaberel 2 Publications Verification ERB-041	Estrogen Receptor/ERR Wnt Apoptosis	Cancer
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC₅₀s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis .

HY-125045

Kahweol eicosanoate

Others Others

Kahweol Eicosanate is a chemopreventive agent .

Kahweol eicosanoate	Others	Others
Kahweol Eicosanate is a chemopreventive agent .

HY-N0628

Kaempferitrin 1 Publications Verification Lespedin; Lespenephryl	Insulin Receptor	Metabolic Disease Endocrinology Cancer
Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

HY-13748

Silybin A Maximum Cited Publications 10 Publications Verification Silibinin A	Autophagy Reactive Oxygen Species	Cancer
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-N2233

Rhapontigenin 3'-O-glucoside 1 Publications Verification
Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin. Rhapontigenin is a potent inactivator of human P450 1A1 and is a good candidate for a cancer chemopreventive agent .

HY-N0708

Vanillic acid	NF-κB Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects .

HY-N4093

Astringin trans-Astringin	Others	Cancer
Astringin (trans-Astringin) is a natural glycoside found in the bark of Picea sitchensis and Picea abies (Norway spruce), in Vitis vinifera cell cultures and in wine. Astringin has potent antioxidant capacity and cancer-chemopreventive activity .

HY-N7335

Dehydroglyasperin C	Others	Neurological Disease Inflammation/Immunology Cancer
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities .

HY-N2459

Peonidin chloride YGM-6 chloride	COX	Cancer
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-13425

Deguelin 5 Publications Verification (-)-Deguelin; (-)-cis-Deguelin	Akt Autophagy Apoptosis	Cancer
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N7563

α-Toxicarol	EBV	Infection Cancer
α-Toxicarol is a potent inhibitor of EBV.α-Toxicarol significantly inhibits mouse skin tumor in vivo. α-Toxicarol inhibits the TPA-induced EBV-EA activation .

HY-N6257

Cafestol 1 Publications Verification	ERK PGE synthase COX NF-κB	Inflammation/Immunology Cancer
Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE₂ production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE₂ production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects .

HY-N7691

3,29-O-Dibenzoyloxykarounidiol Karounidiol dibenzoate	EBV	Infection Cancer
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) .

HY-N9451

Ginger extract

NF-κB Inflammation/Immunology Cancer

Ginger extract exhibits anti-cancer, anti-inflammatory and chemotherapeutic effects in vivo .

Ginger extract	NF-κB	Inflammation/Immunology Cancer
Ginger extract exhibits anti-cancer, anti-inflammatory and chemotherapeutic effects in vivo .

HY-124953

7,3',4'-Trihydroxyisoflavone	MAP3K Apoptosis	Cancer
7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities .

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Inflammation/Immunology Cancer
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Parasite Bacterial Apoptosis Glucosidase Endogenous Metabolite	Infection Metabolic Disease Cancer
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

Murrayone	Classification of Application Fields Source classification Murraya paniculata (L.) Jack. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Others
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .

β-Damascone	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Others
β-Damascone is an aroma active rice volatile and is widely used in perfume compositions. β-Damascone has also received certain attention as a potential cancer chemopreventive and a mosquito and muscoid insecticide .

Se-Methylselenocysteine 2 Publications Verification Methylselenocysteine; Se-Methylseleno-L-cysteine	Structural Classification other families Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Beta-secretase
Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis .

Ailanthoidol	Structural Classification Monophenols Classification of Application Fields Zanthoxylum chalybeum Engl. Source classification Lignans Rutaceae Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion .

(-)-Pinoresinol	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Glucosidase Apoptosis
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride; Se-Methylseleno-L-cysteine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis Beta-secretase
Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis .

L-SelenoMethionine 1 Publications Verification	Structural Classification Microorganisms other families Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .

Aschantin	Structural Classification Natural Products Source classification Magnoliaceae Yulania biondii (Pamp.) D. L. Fu Plants	mTOR Cytochrome P450
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca ²⁺-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme .

Silymarin 4 Publications Verification	Infection Structural Classification Natural Products Glycine soya Neurological Disease Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Inflammation/Immunology Disease Research Fields	SARS-CoV
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (M ^pro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

Kahweol eicosanoate	Triterpenes Structural Classification Terpenoids Coffea canephora Pierre ex Froehn. Source classification Rubiaceae Plants	Others
Kahweol Eicosanate is a chemopreventive agent .

Kaempferitrin 1 Publications Verification Lespedin; Lespenephryl	Flavonols Flavonoids Classification of Application Fields Leguminosae Source classification Bauhinia × blakeana Dunn Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Endocrinology	Insulin Receptor
Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.

Silybin A Maximum Cited Publications 10 Publications Verification Silibinin A	Flavanonols Structural Classification Flavonoids Glycine soya Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Cancer	Autophagy Reactive Oxygen Species
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

Vanillic acid	Classification of Application Fields Source classification Plants Endogenous metabolite Monophenols Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Phenols Umbelliferae Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC.	NF-κB Bacterial Endogenous Metabolite
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects .

Astringin trans-Astringin	Structural Classification Microorganisms Stilbenes Classification of Application Fields Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Disease Research Fields Cancer	Others
Astringin (trans-Astringin) is a natural glycoside found in the bark of Picea sitchensis and Picea abies (Norway spruce), in Vitis vinifera cell cultures and in wine. Astringin has potent antioxidant capacity and cancer-chemopreventive activity .

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chemopreventive

Inhibitors & Agonists

NaturalProducts

Natural
Products