cholinesterase

By Targets:	Cholinesterase (ChE) (54) Acyltransferase (1) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Bacterial (1) Beta-secretase (1) Biochemical Assay Reagents (1) Chemerin Receptor (1) COX (1) Drug Metabolite (1) Endogenous Metabolite (2) Histamine Receptor (2) Histone Acetyltransferase (1) HSV (1) Isotope-Labeled Compounds (2) mAChR (2) Monoamine Oxidase (7) Parasite (2) Phospholipase (1) Reactive Oxygen Species (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (7) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (45)
Click Chemistry:	Alkynes (3)

Targets Recommended: Cholinesterase (ChE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2798

*Cholinesterase* EC 3.1.1.8; BCHE	Endogenous Metabolite	Others
Cholinesterase infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine .

HY-W027553

Ipidacrine	Cholinesterase (ChE)	Neurological Disease
2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine is a pharmaceutically active compound which is a nootropic agent that acts as cholinesterase inhibitor and is used in research of Alzheimer disease .

HY-16252

Hexafluorenium dibromide Mylaxen	Cholinesterase (ChE)	Neurological Disease
Hexafluorenium dibromide (Mylaxen) is a potent cholinesterase (ChE) inhibitor with pI₅₀ value of 6.96 and K_i value of 2.4 nM for human plasma cholinesterase (ChE) .

HY-122790

2-Hydroxydocosanoic acid

Bacterial Infection

2-Hydroxydocosanoic acid has antioxidant, cholinesterase inhibitory, and antimicrobial activities .

2-Hydroxydocosanoic acid	Bacterial	Infection
2-Hydroxydocosanoic acid has antioxidant, cholinesterase inhibitory, and antimicrobial activities .

HY-156188

AChE-IN-41	Others	Others
AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of *cholinesterase*. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .

HY-N4206

Leptomerine	Cholinesterase (ChE)	Neurological Disease
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-124957

β-NETA	Cholinesterase (ChE) Apoptosis	Cancer
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC₅₀=76 μM) and *cholinesterase* (ChE; IC₅₀=40 µM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC₅₀=1 mM) .

HY-124047

RX 67668	Cholinesterase (ChE)	Neurological Disease
RX 67668 is a potent *cholinesterase* inhibitor with an IC₅₀ of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue .

HY-157437

AChE/BChE-IN-16	Cholinesterase (ChE) Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC₅₀s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H₂O₂-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS) .

HY-119577

Ubretid Distigmine dibromide	Cholinesterase (ChE)	Neurological Disease
Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder .

HY-149300

SB-1436	Cholinesterase (ChE)	Neurological Disease
SB-1436 is an *Cholinesterase* (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with K_is of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research .

HY-17368

Rivastigmine 1 Publications Verification S-Rivastigmine	Cholinesterase (ChE)	Neurological Disease
Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-162061

ChEs/MAOs-IN-1	Monoamine Oxidase	Neurological Disease
ChEs/MAOs-IN-1 (Compound 4i) is a dual inhibitor of cholinesterases (ChEs) and monoamine oxidases (MAOs).ChEs/MAOs-IN-1 has IC₅₀ values of 0.048 μM, 0.89 μM, 3.58 μM, and 0.095 μM for AChE, BChE, MAO-B and MAO-B respectively. ChEs/MAOs-IN-1 can be used in the study of neurodegenerative diseases .

HY-11017

Rivastigmine tartrate 1 Publications Verification ENA 713; SDZ-ENA 713	Cholinesterase (ChE)	Neurological Disease
Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-B0207A

Pyridostigmine bromide

Cholinesterase (ChE) Neurological Disease

Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
HY-120692

Cyclanoline chloride

Cholinesterase (ChE) Neurological Disease

Cyclanoline (chloride) shows cholinesterase inhibitory activity .

Pyridostigmine bromide	Cholinesterase (ChE)	Neurological Disease
Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

Cyclanoline chloride	Cholinesterase (ChE)	Neurological Disease
Cyclanoline (chloride) shows cholinesterase inhibitory activity .

HY-B0423

Neostigmine Bromide Eustigmin bromide; Neoserine bromide	Cholinesterase (ChE)	Metabolic Disease
Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.

HY-131922

Iso-OMPA

Tetraisopropyl pyrophosphoramide
Cholinesterase (ChE) Neurological Disease

Iso-OMPA is an inhibitor of butyrylcholinesterase (BuChE) .

Iso-OMPA Tetraisopropyl pyrophosphoramide	Cholinesterase (ChE)	Neurological Disease
Iso-OMPA is an inhibitor of butyrylcholinesterase (BuChE) .

HY-138097

α-NETA 5 Publications Verification	Chemerin Receptor Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis	Cancer
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits *cholinesterase* (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity .

HY-N3468

Isomerazin

Cholinesterase (ChE) Neurological Disease

Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition .

Isomerazin	Cholinesterase (ChE)	Neurological Disease
Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition .

HY-17530

Aldicarb sulfone	Cholinesterase (ChE)	Others
Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.

HY-B0207AS

Pyridostigmine-d6 bromide	Cholinesterase (ChE)	Others
Pyridostigmine-d₆ (bromide) is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-11017AS

(S)-Rivastigmine-d6 tartrate

Cholinesterase (ChE) Others

(S)-Rivastigmine-d₆ (tartrate) is the deuterium labeled (S)-Rivastigmine, which is an cholinesterase inhibitor.

(S)-Rivastigmine-d6 tartrate	Cholinesterase (ChE)	Others
(S)-Rivastigmine-d₆ (tartrate) is the deuterium labeled (S)-Rivastigmine, which is an cholinesterase inhibitor.

HY-W011246

Velnacrine maleate HP 029; Hydroxytacrine maleate	Cholinesterase (ChE)	Neurological Disease
Velnacrine maleate (HP 029) is an orally active *cholinesterase* inhibitor that can be used for the research of Alzheimer's disease .

HY-149817

AChE-IN-29	Cholinesterase (ChE)	Neurological Disease
AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC₅₀ values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease .

HY-B0207AS1

Pyridostigmine-d3 bromide	Cholinesterase (ChE)	Neurological Disease
Pyridostigmine-d₃ (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-116583

Resorufin butyrate

Cholinesterase (ChE) Metabolic Disease

Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .

Resorufin butyrate	Cholinesterase (ChE)	Metabolic Disease
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and *cholinesterase* (Ex=570 nm, Em=580 nm) .

HY-121745

Phosmet oxon Imidoxon; Oxoimidan	Drug Metabolite	Infection
Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits .

HY-I0020

Galanthaminone (-)-Narwedine; Narwedin	Cholinesterase (ChE)	Neurological Disease
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

HY-107275

Ebeiedinone	Cholinesterase (ChE)	Neurological Disease
Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0% .

HY-107569

Garcinol 1 Publications Verification	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards *acetyl cholinesterase* (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀** = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-B0841

Acephate	Cholinesterase (ChE)	Neurological Disease
Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture .

HY-B1626A

Demecarium Bromide BC-48	Cholinesterase (ChE)	Neurological Disease
Demecarium Bromide (BC-48) is a potent *cholinesterase* inhibitor, with an apparent affinity (K_iapp) of 0.15 μM . Demecarium Bromide (BC-48) is used as a glaucoma agent .

HY-N12133

4,7-Didehydroneophysalin B	Others	Metabolic Disease
4,7-Didehydroneophysalin B is a flavonoid with cholinesterase inhibiting activity. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research .

HY-D0904

Acetylthiocholine iodide S-Acetylthiocholine iodide; ATCh iodide	Biochemical Assay Reagents	Others
Acetylthiocholine iodide can be used as a substrate for certain enzymes, such as cholinesterase, etc., and can be used to determine the activity level of these enzymes. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology.

HY-155714

AChE-IN-35

Cholinesterase (ChE) Neurological Disease

AChE-IN-35 (compound 5g) is an AChE inhibitor with the IC₅₀ of 5.88 μM .

AChE-IN-35	Cholinesterase (ChE)	Neurological Disease
AChE-IN-35 (compound 5g) is an AChE inhibitor with the IC₅₀ of 5.88 μM .

HY-P4281

Ovotransferrin (328-332)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease
Ovotransferrin (328-332) has a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), with the IC₅₀ of 20 μM. Ovotransferrin (328-332) fragment has an activity against Cholinesterase (ChE), implicating in Alzheimer’s diseases .

HY-B1885

Fenitrothion	Parasite Cholinesterase (ChE)	Infection
Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols .

HY-131127

7-Acetoxy-1-methylquinolinium iodide AMQI	Cholinesterase (ChE)	Others
7-Acetoxy-1-methylquinolinium iodide (AMQI) is a fluorogenic substrate for cholinesterase (Ex = 320 nm, Em = 410 nm). Hydrolysis of 7-acetoxy-1-methylquinolinium iodide is used at the fluorometric flow system for the detection and identification of inhibitors. .

HY-N12581

Kuwanon U	Cholinesterase (ChE)	Neurological Disease
Kuwanon U is a potent *cholinesterase* inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-133776

Rivastigmine carbamate impurity 3-Nitrophenyl ethyl(methyl)carbamate	Cholinesterase (ChE)	Neurological Disease
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively .

HY-155708

AChE/BChE-IN-13	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-13 (compound 5j) is a potent dual inhibitor of AChE and BChE with IC₅₀s of 20.89 and 17.37 μM, respectively. AChE/BChE-IN-13 can be used in Alzheimer’s disease (AD) research .

HY-N12038

Coumarinic acid	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. Coumarinic acid can be used in study anti-Alzheimer drug .

HY-156031

BChE-IN-19	Cholinesterase (ChE)	Neurological Disease
BChE-IN-19 (Compound 7b) is a para-substituted derivative of indone (7b) with inhibitory activity of butyryl cholinesterase (BChE) (IC₅₀=0.04 μM). BChE-IN-19 improves cholinergic scheduling in the nervous system. BChE-IN-19 can be used against Alzheimer's disease .

HY-107416

RHC 80267 U-57908	Acyltransferase mAChR COX Phospholipase	Neurological Disease Metabolic Disease
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits *cholinesterase* activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) .

HY-B1120S

Temephos-d12 Temefos-d₁₂	Parasite	Infection
Temephos-d₁₂ is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].

HY-B1885S

Fenitrothion-d6	Isotope-Labeled Compounds Cholinesterase (ChE)	Infection
Fenitrothion-d₆ is the deuterium labeled Fenitrothion[1]. Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols[2][3].

HY-105327

P11149	Cholinesterase (ChE)	Neurological Disease
P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC₅₀ of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease .

HY-136838

(R)-Donepezil (R)-E2020 free base	Cholinesterase (ChE)	Neurological Disease Cancer
(R)-Donepezil is a R-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor .

Cat. No.	Product Name	Type

HY-116583

Resorufin butyrate

Fluorescent Dyes/Probes

Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .

Cat. No.	Product Name	Type

HY-P2798

*Cholinesterase* EC 3.1.1.8; BCHE	Biochemical Assay Reagents
Cholinesterase infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine .

HY-D0904

Acetylthiocholine iodide S-Acetylthiocholine iodide; ATCh iodide	Biochemical Assay Reagents
Acetylthiocholine iodide can be used as a substrate for certain enzymes, such as cholinesterase, etc., and can be used to determine the activity level of these enzymes. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology.

Cat. No.	Product Name	Target	Research Area

HY-P4281

Ovotransferrin (328-332)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease
Ovotransferrin (328-332) has a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), with the IC₅₀ of 20 μM. Ovotransferrin (328-332) fragment has an activity against Cholinesterase (ChE), implicating in Alzheimer’s diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-120692

Cyclanoline chloride	Alkaloids Cyclea insularis (Makino) Hatusima Source classification Plants Isoquinoline Alkaloids Menispermaceae	Cholinesterase (ChE)
Cyclanoline (chloride) shows cholinesterase inhibitory activity .

HY-N3468

Isomerazin	other families Source classification Coumarins Phenylpropanoids Plants	Cholinesterase (ChE)
Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition .

HY-107275

Ebeiedinone	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Source classification Plants Fritillaria ussuriensis Maxim.	Cholinesterase (ChE)
Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0% .

HY-122790

2-Hydroxydocosanoic acid	Infection Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial
2-Hydroxydocosanoic acid has antioxidant, cholinesterase inhibitory, and antimicrobial activities .

HY-N4206

Leptomerine	Alkaloids other families Source classification Quinoline Alkaloids Plants	Cholinesterase (ChE)
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-107569

Garcinol 1 Publications Verification	Structural Classification Classification of Application Fields Guttiferae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Garcinia indica	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards *acetyl cholinesterase* (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀** = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N12133

4,7-Didehydroneophysalin B	Structural Classification Natural Products Source classification Plants Solanaceae Alkekengi officinarum Moench	Others
4,7-Didehydroneophysalin B is a flavonoid with cholinesterase inhibiting activity. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Cholinesterase (ChE) Monoamine Oxidase
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research .

HY-N12581

Kuwanon U	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	Cholinesterase (ChE)
Kuwanon U is a potent *cholinesterase* inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-N12038

Coumarinic acid	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols	Amyloid-β Cholinesterase (ChE)
Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. Coumarinic acid can be used in study anti-Alzheimer drug .

HY-N7346

Lucidadiol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HSV Cholinesterase (ChE)
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-N10917

Xanthohumol I	Structural Classification Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae	Cholinesterase (ChE)
Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC₅₀s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC₅₀s of 51.25 μM and 63.07 μM .

HY-N9347

Stepharine 1 Publications Verification	Cardiovascular Disease Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Toll-like Receptor (TLR)
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Flavanonols Flavonoids Source classification Plants Rhus glabra L. Anacardiaceae	Amyloid-β mAChR Cholinesterase (ChE)
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .

Species:	Human (3) Mouse (1)
Tag:	His (3) GST (2) Flag (2)
Source:	HEK293 (2) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72859

	Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) cholinesterase; Acylcholine acylhydrolase; Choline esterase II; BCHE	Mouse	HEK293
	Butyrylcholinesterase (BCHE) Protein, an esterase with broad substrate specificity, crucially inactivates acetylcholine, maintaining neurotransmitter homeostasis. Beyond acetylcholine metabolism, BCHE degrades neurotoxic organophosphates, highlighting its detoxification role. The enzyme's versatility underscores its critical function in safeguarding against harmful effects of neurotoxic compounds. Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) is the recombinant mouse-derived Butyrylcholinesterase/BCHE protein, expressed by HEK293 , with C-His labeled tag. The total length of Butyrylcholinesterase/BCHE Protein, Mouse (HEK293, His) is 576 a.a., with molecular weight of 60-70 kDa.

HY-P7690

	BCHE Protein, Human (HEK293, His) rHuBCHE, His; Butyrylcholine Esterase; BCHE; Choline Esterase II	Human	HEK293
	BCHE Protein, Human (HEK293, His) is a recombinant human butyrylcholinesterase (BuChE) produced in HEK293 cells, with His tag. BuChE, one of cholinesterases, is a serine hydrolase closely related to acetylcholinesterase.

HY-P702693

	CDK13-CCNK Protein, Human (sf9, GST, Flag) CDK13; cyclin-dependent kinase 13; CDC2L5, cell division cycle 2 like 5 (cholinesterase related cell division controller); CDC2L; CHED; cholinesterase related cell division controller; KIAA1791; CDC2-related protein kinase 5; cell division protein kinase 13; cell division cycle 2-like protein kinase 5; cholinesterase-related cell division controller; CDC2L5; hCDK13; FLJ35215	Human	Sf9 insect cells

HY-P702694

	CDK13-CCNT1 Protein, Human (sf9, GST, Flag, His) CDK13; cyclin-dependent kinase 13; CDC2L5, cell division cycle 2 like 5 (cholinesterase related cell division controller); CDC2L; CHED; cholinesterase related cell division controller; KIAA1791; CDC2-related protein kinase 5; cell division protein kinase 13; cell division cycle 2-like protein kinase 5; cholinesterase-related cell division controller; CDC2L5; hCDK13; FLJ35215	Human	Sf9 insect cells

Cat. No.	Product Name	Chemical Structure

HY-B0207AS

Pyridostigmine-d6 bromide

Pyridostigmine-d₆ (bromide) is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.
HY-11017AS

(S)-Rivastigmine-d6 tartrate

(S)-Rivastigmine-d₆ (tartrate) is the deuterium labeled (S)-Rivastigmine, which is an cholinesterase inhibitor.

HY-B0207AS1

Pyridostigmine-d3 bromide
Pyridostigmine-d₃ (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-B1120S

Temephos-d12
Temephos-d₁₂ is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].

HY-B1885S

Fenitrothion-d6
Fenitrothion-d₆ is the deuterium labeled Fenitrothion[1]. Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols[2][3].

HY-17368S1

(rac)-Rivastigmine-d6

(rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (S-Rivastigmine) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P82715

Butyrylcholinesterase Antibody (YA2460)

BCHE; Butyrylcholine esterase; CHE1; CHE2; Choline esterase II; cholinesterase (serum) 2; cholinesterase 1; cholinesterase; E1
WB Human

Cat. No.	Product Name		Classification

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of *cholinesterase* and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


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