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Results for "

claudin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Claudin (19) ADC Antibody (1) Akt (3) Amyloid-β (1) Biochemical Assay Reagents (2) Cadherin (2) CD3 (1) Endogenous Metabolite (1) ERK (1) Gap Junction Protein (4) HCV (1) HSP (2) Interleukin Related (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) Natriuretic Peptide Receptor (NPR) (1) PI3K (3) Reference Standards (1) Tie (2) TNF Receptor (4) Transthyretin (TTR) (1) α-synuclein (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Claudin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113283

Homogentisic acid	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin	Neurological Disease Metabolic Disease Cancer
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-P9991

Osemitamab TST001	Gap Junction Protein	Cancer
Osemitamab is an IgG1 antibody targeting to human *claudin-18.2*. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .

HY-W014507

9,10-Phenanthrenequinone	Claudin	Cancer
9,10-Phenanthrenequinone is an inhibitor of *claudin-5/CLDN5* that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis .

HY-P10580

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and *claudin-5*), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

HY-P99413

IMAB027 ASP1650	HCV	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-153833

PDS-0330 1 Publications Verification KVA-E-23A	Gap Junction Protein	Cancer
PDS-0330 is a specific and potent *Claudin-1* inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis .

HY-P991143

Ixotatug TORL-1-23 Antibody	Claudin	Cancer
Ixotatug is a monoclonal antibody targeting human CLDN6 (claudin-6). Ixotatug specifically binds to CLDN6, interfering with relevant signaling pathways in tumor cells and exerting antitumor activity. Ixotatug is promising for research of cancers .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P6083

RTSPSSR	Biochemical Assay Reagents	Others Cancer
RTSPSSR is synthesized peptide, which binds specifically to *claudin-1* and visulizes the CRC tumor in mice, through near-infrared fluorescence imaging .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

HY-P10580A

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and *claudin-5*), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

HY-158990

GE1111	Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related TNF Receptor Akt ERK	Inflammation/Immunology
GE1111 is a MRGPRX2 antagonist (IC₅₀ = 9.4 μM). GE1111 inhibits MRGPRX2/MRGPRB2-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, MCP-1, TNF-α, IL-1β and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis .

HY-171152A

NSC 357754 dihydrochloride	Claudin	Metabolic Disease
NSC 357754 dihydrochloride is an inhibitor of *Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2* and/or *Claudin-15* .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers .

HY-100987

Lauroylcarnitine chloride	Biochemical Assay Reagents	Others
Lauroylcarnitine chloride enhances the absorption of salmon calcitonin in rats. Also in determining in situ bioavailability, increased availability of Lucifer yellow and decreased expression of claudin-4 protein in the colon .

HY-P991679

Elatatug TORL-2-307 antibody	Claudin	Cancer
Elatatug is an anti-*CLDN18 (claudin* 18)** IgG1κ type humanized antibody with antineoplastic activity. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Reference Standards TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-171152

NSC 357754	Claudin	Metabolic Disease
NSC 357754 is an inhibitor of *Claudin. NSC 357754 can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 can be used in the research of intestinal diseases mediated by Claudin-2* and/or *Claudin-15* .

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human CLDN18 (claudin-18). Garetatug specifically binds to CLDN18, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P9991A

Osemitamab (FUT8-KO)	Gap Junction Protein	Cancer
Osemitamab (FUT8-KO) is an anti-claudin-18.2 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .

HY-E70609

PIK3CG Recombinant Human Active Lipid Kinase	PI3K	Inflammation/Immunology Cancer
PIK3CG Recombinant Human Active Lipid Kinase belongs to PI3K enzyme family that is directly regulated by Gβγ and Ras in the G protein coupled receptor (GPCR) pathway. PIK3CG has the function of regulating cellular inflammation and immunity. PIK3CG is also a potential target for the treatment of a few malignant tumors such as acute lymphoblastic leukemia, medulloblastoma, claudin-low breast cancer (CLBC) and Kaposi sarcoma .

HY-P992220

*Anti-Claudin* 6 Antibody (IM-302)**	Claudin	Cancer
Anti-Claudin 6 Antibody (IM-302) is a human monoclonal antibody targeting *Claudin-6/CLDN6. Anti-Claudin* 6 Antibody (IM-302) can be used in cancer research.

HY-P992219

*Anti-Claudin* 1 Antibody**	Claudin	Inflammation/Immunology
Anti-Claudin 1 Antibody is a monoclonal antibody targeting CLDN1/CLD1/SEMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Claudin 1 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

HY-N17783A

Sanleng acid	Endogenous Metabolite	Inflammation/Immunology
Sanleng acid is an unsaturated fatty acid compound that can be isolated from the hexane extract of Magnolia sieboldii (MsHE). MsHE can inhibit the expression of inflammatory mediators (such as COX-2) and pro-inflammatory cytokines (such as TNF-α, IL-1β), and increase the expression of tight junction proteins (claudin-4, *claudin-5*) to protect epithelial cell barrier function, thus exerting anti-inflammatory activity. Related compounds may be used in research related to reflux esophagitis (RE).

HY-P11785

Cpe30 MT2	Claudin	Cancer
Cpe30 MT2 is a short peptide that binds tightly junction protein Claudin‑4 (CLDN4) with high affinity, with a K_d value of 1.97 nM. Cpe30 MT2 can be used for the synthesis of PET molecular imaging probes targeting pancreatic cancer .

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

Cat. No.	Product Name	Target	Research Area

HY-P10580

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and *claudin-5*), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

HY-P6083

RTSPSSR	Biochemical Assay Reagents	Others Cancer
RTSPSSR is synthesized peptide, which binds specifically to *claudin-1* and visulizes the CRC tumor in mice, through near-infrared fluorescence imaging .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

HY-P10580A

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and *claudin-5*), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

HY-P11785

Cpe30 MT2	Claudin	Cancer
Cpe30 MT2 is a short peptide that binds tightly junction protein Claudin‑4 (CLDN4) with high affinity, with a K_d value of 1.97 nM. Cpe30 MT2 can be used for the synthesis of PET molecular imaging probes targeting pancreatic cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99058

Zolbetuximab 4 Publications Verification IMAB362; Claudiximab; GC-182	Inhibitory Antibodies	Cancer
Zolbetuximab (IMAB362) is a monoclonal antibody targeting *Claudin-18.2. Zolbetuximab mediates specific killing of Claudin*-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors .

HY-P9991

Osemitamab TST001	Gap Junction Protein	Cancer
Osemitamab is an IgG1 antibody targeting to human *claudin-18.2*. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .

HY-P99413

IMAB027 ASP1650	HCV	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P991143

Ixotatug TORL-1-23 Antibody	Claudin	Cancer
Ixotatug is a monoclonal antibody targeting human CLDN6 (claudin-6). Ixotatug specifically binds to CLDN6, interfering with relevant signaling pathways in tumor cells and exerting antitumor activity. Ixotatug is promising for research of cancers .

HY-P990742

Givastomig TJ-CD4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P991163

Tixentamig	CD3 Claudin	Cancer
Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers .

HY-P991679

Elatatug TORL-2-307 antibody	Claudin	Cancer
Elatatug is an anti-*CLDN18 (claudin* 18)** IgG1κ type humanized antibody with antineoplastic activity. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991140

Garetatug	Claudin	Cancer
Garetatug is a humanized monoclonal antibody targeting human CLDN18 (claudin-18). Garetatug specifically binds to CLDN18, interfering with relevant cell signaling pathways and exerting antitumor activity .

HY-P9991A

Osemitamab (FUT8-KO)	Gap Junction Protein	Cancer
Osemitamab (FUT8-KO) is an anti-claudin-18.2 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .

HY-P992220

*Anti-Claudin* 6 Antibody (IM-302)**	Claudin	Cancer
Anti-Claudin 6 Antibody (IM-302) is a human monoclonal antibody targeting *Claudin-6/CLDN6. Anti-Claudin* 6 Antibody (IM-302) can be used in cancer research.

HY-P992219

*Anti-Claudin* 1 Antibody**	Claudin	Inflammation/Immunology
Anti-Claudin 1 Antibody is a monoclonal antibody targeting CLDN1/CLD1/SEMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Claudin 1 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992316

ATG-022 Antibody	Claudin ADC Antibody	Cancer
ATG-022 Antibody is a humanized monoclonal antibody targeting Claudin 18.2 (CLDN 18.2). ATG-022 Antibody binds with VcMMAE (HY-15575) to form an Antibody-Drug Conjugate (ADC). ATG-022 Antibody can be used for the research of advanced/metastatic solid tumors and gastric cancer .

HY-P992412

MIL93	Claudin	Cancer
MIL93 is a humanized defucosylated IgG1 monoclonal antibody targeting *Claudin18.2* (CLDN18.2) with enhanced antibody-dependent cellular cytotoxicity (ADCC) activity. MIL93 can be used for research on advanced solid tumors and gastric cancer. The recommended isotype control is human IgG1 kappa (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113283

Homogentisic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	Zea mays L. Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharides Source Classification	TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Structural Classification Zea mays L. Polysaccharides Gramineae Plants Saccharides Source Classification	Reference Standards TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N17783A

Sanleng acid	Structural Classification Ketones, Aldehydes, Acids Magnoliaceae Oyama sieboldii (K. Koch) N. H. Xia & C. Y. Wu Plants Source Classification	Endogenous Metabolite
Sanleng acid is an unsaturated fatty acid compound that can be isolated from the hexane extract of Magnolia sieboldii (MsHE). MsHE can inhibit the expression of inflammatory mediators (such as COX-2) and pro-inflammatory cytokines (such as TNF-α, IL-1β), and increase the expression of tight junction proteins (claudin-4, *claudin-5*) to protect epithelial cell barrier function, thus exerting anti-inflammatory activity. Related compounds may be used in research related to reflux esophagitis (RE).

Species:	Human (34) Mouse (2) Cynomolgus (2)
Tag:	GFP (3) mCherry (1) His (23) Strep (3) Tag Free (12) Avi (3) B2M (1) Fc (1) Flag (3)
Source:	HEK293 (30) E. coli Cell-free (2) sf9 insect cells (4) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700691

	Claudin-6/CLDN6 Protein-VLP, Cynomolgus (HEK293) claudin-6; Skullin; CLDN6; claudin6; Skullin 2; EGM_11390; claudin	Cynomolgus	HEK293
	Claudin-6/CLDN6 Protein-VLP, Cynomolgus (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700692

	Claudin-6/CLDN6 Protein-VLP, Mouse (HEK293) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Mouse	HEK293
	Claudin-6/CLDN6 Protein-VLP, Mouse (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77899A

	Claudin-6/CLDN6 Protein-VLP, Human (HEK293) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. May have binding signals with Anti-His antibodies.

HY-P703889

	Claudin-6 Protein-Nanodisc, Human (HEK293, GFP, His) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP is pivotal in targeted elimination of intercellular spaces within tight junctions, ensuring cell barrier integrity and polarity. Moreover, it serves as a receptor for hepatitis C virus (HCV), facilitating viral entry into hepatic cells. Claudin-6 Protein-Nanodisc, Human (HEK293, GFP, His) is the recombinant human-derived Claudin-6 protein, expressed by HEK293, with C-His and C-GFP labeled tag.

HY-P70701

	Claudin-18/CLDN18.2 Protein, Human (His) claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by E. coli , with N-8*His labeled tag. The complete sequence length is 172 amino acids. In addition to the target fragment P56856-2 (D28-L76), there are other fusion sequences that play a role in stabilizing the extracellular region.

HY-P700407

	Claudin-9/CLDN9 Protein-VLP, Human (HEK293, His) claudin-9	Human	HEK293
	Claudin-9/CLDN9 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P77899

	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, solution) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77900

	Claudin-6/CLDN6 Protein-VLP, Human (Biotinylated, HEK293) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P77899 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700406

	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, His) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P702596

	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, GFP) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, GFP) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P702247

	Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry) claudin-18	Human	HEK293
	Claudin-18/CLDN18.1 Protein-VLP, Human (HEK293, mCherry) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P703890

	Claudin-9/CLDN9 Protein-VLP, Human (HEK293) claudin-9; CLD9	Human	HEK293
	Claudin-9/CLDN9 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P704512

	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, GFP, solution) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP, Human (HEK293, GFP, solution) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P704510

	Claudin-6/CLDN6 Protein-Nanodisc, Human (sf9, His, Twin-Strep) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	sf9 insect cells

HY-P704511

	Claudin-6/CLDN6 Protein-Nanodisc, Human (HEK293, His, Flag, GFP) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	HEK293
	Claudin-6/CLDN6 Protein-VLP is pivotal in targeted elimination of intercellular spaces within tight junctions, ensuring cell barrier integrity and polarity. Moreover, it serves as a receptor for hepatitis C virus (HCV), facilitating viral entry into hepatic cells. Claudin-6/CLDN6 Protein-Nanodisc, Human (HEK293, His, Flag, GFP) is the recombinant human-derived Claudin-6/CLDN6 protein, expressed by HEK293, with N-His and C-GFP and N-Flag labeled tag.

HY-P705009

	Claudin-6/CLDN6 Protein-Nanodisc, Human (Biotinylated, sf9, Flag, His-Avi) claudin-6; Skullin; CLDN6; claudin6; Skullin 2	Human	sf9 insect cells

HY-P74250

	Claudin-11/CLDN11 Protein, Human (HEK293, Fc) claudin-11; CLDN11; OSP; OTM	Human	HEK293
	Claudin-11/CLDN11 Protein plays a crucial role in tightly closing intercellular spaces in tight junctions, facilitated by its calcium-independent cell-adhesion capabilities. Interacting with tetraspanin-3/TSPAN3 suggests potential collaboration in cellular processes. CLDN11's associations with OCLN highlight its involvement in molecular interactions, contributing to the structural integrity and functional regulation of tight junctions. Claudin-11/CLDN11 Protein, Human (HEK293, Fc) is the recombinant human-derived Claudin-11/CLDN11 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P703891

	Claudin-9/CLDN9 Protein-Nanodisc, Human (Biotinylated, HEK293, His, Avi) claudin-9; CLD9	Human	HEK293
	Claudin-9/CLDN9 protein-VLP plays a crucial role in tight junctions by eliminating intercellular spaces through calcium-independent cell adhesion activity. In microbial infections, it acts as a receptor that facilitates the entry of hepatitis C virus (HCV) into hepatocytes. Claudin-9/CLDN9 Protein-Nanodisc, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived Claudin-9/CLDN9 protein, expressed by HEK293, with C-His and C-Avi labeled tag.

HY-P78368

	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293) is recommended for SPR analysis, animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P70045

	Claudin-18/CLDN18.1 Protein, Human (His) rHuclaudin-18/CLDN18, His; claudin-18; CLDN18	Human	E. coli
	CLDN18 play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.1 Protein, Human (His) is the recombinant human-derived Claudin-18/CLDN18.1 protein, expressed by E. coli , with N-8*His labeled tag. The complete sequence length is 171 amino acids. In addition to the target fragment P56856-1 (D28-L76), there are other fusion sequences that play a role in stabilizing the extracellular region.

HY-P700403

	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P78105

	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P78368 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P700440

	Claudin-18/CLDN18.2 Protein-VLP, Cynomolgus (HEK293, His) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Cynomolgus	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704502

	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, GFP) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Human (HEK293, GFP) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P704504

	Claudin-18/CLDN18.2 Protein-Nanodisc, Human (sf9, Twin Strep) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells
	CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. Claudin-18/CLDN18.2 Protein-Nanodisc, Human (sf9, Twin Strep) is the recombinant human-derived Claudin-18/CLDN18.2 protein, expressed by sf9 insect cells, with C-Twin-Strep and N-His labeled tag.

HY-P700405

	Claudin-4/CLDN4 Protein-VLP, Human (HEK293, His) CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein;	Human	HEK293
	Claudin-4/CLDN4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704508

	Claudin-4/CLDN4 Protein-VLP, Human (HEK293) CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein;	Human	HEK293
	Claudin-4/CLDN4 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P705008

	Claudin-18/CLDN18.2 Protein-Nanodisc, Human (Biotinylated, sf9, Flag, His-Avi) CLDN18; CLDN18.2; claudin-18.2; claudin-18; DKFZp564B2062; SFTA5; SFTPJ	Human	sf9 insect cells

HY-P703888

	Claudin-4/CLDN4 Protein-Nanodisc, Human (HEK293,His, Strep) CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein;	Human	HEK293
	Claudin-4/CLDN4 protein-VLP is a channel-forming tight junction protein that promotes paracellular chloride transport in the kidney. It is essential for the reabsorption of filtered chloride in the collecting duct. Claudin-4/CLDN4 Protein-Nanodisc, Human (HEK293,His, Strep) is the recombinant human-derived Claudin-4/CLDN4 protein, expressed by HEK293, with C-Strep and N-His labeled tag.

HY-P700404

	Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) rHuclaudin-18/CLDN18, His; claudin-18; CLDN18	Mouse	HEK293
	Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704228

	Claudin-1 Protein-VLP, Human (HEK293) CLD1; LILVASC; LSEMP1	Human	HEK293
	Claudin-1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P705644

	Claudin-1 Protein-VLP, Human (HEK293, His) CLD1; LILVASC; LSEMP1	Human	HEK293
	Claudin-1 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P705967

	Claudin-6/CLDN6 Protein-VLP, Chlorocebus sabaeus (HEK293, His) CLDN6	Others	HEK293
	Claudin-6/CLDN6 Protein-VLP, Chlorocebus sabaeus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P705964

	Claudin-18/CLDN18.2 Protein, Human (HEK293, His, Detergent) CLDN18.2	Human	HEK293
	As a membrane protein, Claudin-18/CLDN18.2 requires a detergent system to maintain its solubility and biological activity. The designated system consists of 10% (w/v) DDM and 2% (w/v) CHS, both of which are essential components for preserving protein stability and function. Under no circumstances should these detergents be removed.

HY-P702245

	CLDN1 Protein, Human (Cell-Free, His) claudin-1; Senescence-associated epithelial membrane protein	Human	E. coli Cell-free
	The CLDN1 protein is a tight junction component that regulates epithelial permeability. CLDN1 Protein, Human (Cell-Free, His) is the recombinant human-derived CLDN1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P706001

	CLDN7 Protein, Human (Cell-Free, His) CLDN7; CEPTRL2; CPETRL2; claudin-7; CLDN-7	Human	E. coli Cell-free

HY-P72146

	Claudin-3/CLDN3 Protein, Human (His-B2M) C7orf1; claudin-3; claudin3; CLD3_HUMAN; CLDN 3; Cldn3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPE-R 2; CPE-receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; Rat ventral prostate.1 protein homolog; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog	Human	E. coli
	Claudin-3/CLDN3 proteins play a critical role in tight junctions, eliminating intercellular spaces through calcium-independent cell adhesion activity. It exhibits multifunctionality by forming homo- and heteropolymers with other CLDN members, including CLDN1 and CLDN2. Claudin-3/CLDN3 Protein, Human (His-B2M) is the recombinant human-derived Claudin-3/CLDN3 protein, expressed by E. coli , with N-6*His, B2M labeled tag.

HY-P700472

	Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His) C7orf1; claudin-3; claudin3; CLD3_HUMAN; CLDN 3; Cldn3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPE-R 2; CPE-receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; Rat ventral prostate.1 protein homolog; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog	Human	HEK293
	Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P704506

	Claudin-3/CLDN3 Protein-VLP, Human (HEK293) C7orf1; claudin-3; claudin3; CLD3_HUMAN; CLDN 3; Cldn3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPE-R 2; CPE-receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; Rat ventral prostate.1 protein homolog; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog	Human	HEK293
	Claudin-3/CLDN3 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

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Host:	Mouse (11) Rabbit (14)
Reactivity:	Human (25) Rat (9) Mouse (10)
Application:	IHC-P (20) ICC/IF (10) mIHC (2) IF-Tissue (1) IP (6) WB (15) FC (4) ELISA (12)
Isotype:	IgG (13) IgG2b,IgG/Kappa (1) IgG1 (5) IgG/Kappa (1) IgG2b (4)
Conjugation:	Non-conjugated (25) Biotin (5)
Clonality:	Polyclonal (1) Monoclonal (18) Recombinant (7)
Modification:	Unmodified (20)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85995

	Claudin 18 Antibody (YA5687) claudin-18	IHC-P, ELISA	Human
	Claudin 18 Antibody (YA5687) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.

HY-P82589

	Claudin 11 Antibody (YA2334) claudin 11; CLD11_HUMAN; Cldn11; OSP; OTM	WB, FC	Human, Mouse, Rat
	Claudin 11 Antibody (YA2334) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 11.

HY-P85954

	Claudin 4 Antibody (YA5646)	IHC-P, WB, ICC/IF, ELISA	Human
	Claudin 4 Antibody (YA5646) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 4.

HY-P87958

	Claudin 5 Antibody (YA7643)	WB, IHC-P	Human
	Claudin 5 Antibody (YA7643) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 5.

HY-P85798

	Claudin 7 Antibody (YA5490) CEPTR L2; CEPTRL 2; CEPTRL2; claudin 1; claudin 7; claudin 9; claudin-7; claudin1; claudin7; claudin9; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359	IHC-P, WB, ICC/IF, ELISA	Human
	Claudin 7 Antibody (YA5490) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 7.

HY-P85996

	Claudin 7 Antibody (YA5688) CEPTR L2; CEPTRL 2; CEPTRL2; claudin 1; claudin 7; claudin 9; claudin-7; claudin1; claudin7; claudin9; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359	IHC-P, ELISA	Human
	Claudin 7 Antibody (YA5688) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 7.

HY-P86030

	Claudin 7 Antibody (YA5722) CEPTR L2; CEPTRL 2; CEPTRL2; claudin 1; claudin 7; claudin 9; claudin-7; claudin1; claudin7; claudin9; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359	IHC-P, ELISA	Human, Mouse, Rat
	Claudin 7 Antibody (YA5722) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 7.

HY-P81222A

	Claudin 1 Antibody (YA3551) CLD1_HUMAN; claudin-1; claudin 1; claudin1; CLD1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944; ILVASC;	WB, IHC-P	Human, Mouse, Rat
	Claudin 1 Antibody (YA3551) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 1.

HY-P85953

	Claudin 1 Antibody (YA5645) claudin-1; Senescence-associated epithelial membrane protein;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Claudin 1 Antibody (YA5645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 1.

HY-P81424

	Claudin 8 Antibody (YA1169) CLDN8; UNQ779/PRO1573 ; claudin-8	IHC-P	Human
	Claudin 8 Antibody (YA1169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 8.

HY-P85778

	Claudin-2 Antibody (YA5470) claudin-2; SP82;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Claudin-2 Antibody (YA5470) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Claudin-2.

HY-P85797

	Claudin-2 Antibody (YA5489) claudin-2; SP82;	IHC-P, WB, ICC/IF, ELISA	Human
	Claudin-2 Antibody (YA5489) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin-2.

HY-P81424A

	Claudin 8 Antibody (YA1169)(PBS only) CLDN8; UNQ779/PRO1573 ; claudin-8	IHC-P	Human
	Claudin 8 Antibody (YA1169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 8.

HY-P81773

	Claudin 18.2 Antibody CLDN 18.2,claudin 18.2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Claudin 18.2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Claudin 18.2.

HY-P85991

	Claudin 18.1 Antibody (YA5683) claudin 18 antibody; claudin-18 antibody; CLD18_HUMAN antibody; CLDN18 antibody; SFTA5 antibody; SFTPJ antibody;	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Claudin 18.1 Antibody (YA5683) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.1.

HY-P81419

	Claudin 5 Antibody (YA1164) CLDN5; AWAL; TMVCF; claudin-5; Transmembrane protein deleted in VCFS; TMDVCF	IHC-P, mIHC	Human
	Claudin 5 Antibody (YA1164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 5.

HY-P86518

	Claudin 1 Antibody (YA6210) CLDN1; CLD1; SEMP1; claudin-1; Senescence-associated epithelial membrane protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Claudin 1 Antibody (YA6210) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 1.

HY-P81419A

	Claudin 5 Antibody (YA1164)(PBS only) CLDN5; AWAL; TMVCF; claudin-5; Transmembrane protein deleted in VCFS; TMDVCF	IHC-P, mIHC	Human
	Claudin 5 Antibody (YA1164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 5.

HY-P87419

	Claudin 6/CLDN6 Antibody (YA7107)	FC, ELISA	Human
	Claudin 6/CLDN6 Antibody (YA7107) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 6/CLDN6.

HY-P82767

	Claudin 3 Antibody (YA2512) RVP1; HRVP1; C7orf1; CPE-R2; CPETR2	WB, ICC/IF, IP	Human
	Claudin 3 Antibody (YA2512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 3.

HY-P81606

	Claudin 4 Antibody (YA1351) CLDN4; CPER; CPETR1; WBSCR8; claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein	WB, IHC-P, IP	Human
	Claudin 4 Antibody (YA1351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 4.

HY-P81606A

	Claudin 4 Antibody (YA1351)(PBS only) CLDN4; CPER; CPETR1; WBSCR8; claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein	WB, IHC-P, IP	Human, Mouse
	Claudin 4 Antibody (YA1351) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 4.

HY-P82767A

	Claudin 3 Antibody (YA2512)(PBS only) RVP1; HRVP1; C7orf1; CPE-R2; CPETR2	WB, ICC/IF, IP	Human
	Claudin 3 Antibody (YA2512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 3.

HY-P87419A

	Claudin 6/CLDN6 Antibody (YA7107)(PBS only)	FC, ELISA	Human
	Claudin 6/CLDN6 Antibody (YA7107) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 6/CLDN6.

HY-P86091

	Claudin 3 Antibody (YA5783) C7orf1; claudin-3; claudin3; CLD3_HUMAN; CLDN 3; Cldn3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPE-R 2; CPE-receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; Rat ventral prostate.1 protein homolog; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog	WB, IHC-P, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	Claudin 3 Antibody (YA5783) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 3.

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