Search Result

Isoforms Recommended:	Cleavable

Results for "

cleavable

" in MCE Product Catalog:

By Targets:	ADC Linker (638) Amino Acid Derivatives (1) Androgen Receptor (2) Angiotensin Receptor (2) Antibiotic (3) Antibody-Drug Conjugates (ADCs) (9) Apoptosis (17) Arenavirus (1) Bacterial (6) Beta-secretase (12) Biochemical Assay Reagents (5) Bradykinin Receptor (4) Caspase (3) Checkpoint Kinase (Chk) (1) Complement System (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (46) EGFR (3) Endogenous Metabolite (10) Fluorescent Dye (15) GLUT (1) HDAC (1) Histone Methyltransferase (1) Influenza Virus (1) Integrin (1) Keap1-Nrf2 (1) Mas-related G-protein-coupled Receptor (MRGPR) (2) MDM-2/p53 (1) Microtubule/Tubulin (7) MMP (3) Notch (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) PARP (2) PGE synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (5) Phospholipase (1) Poly(ADP-ribose) Glycohydrolase (PARG) (1) PROTAC Linkers (208) PROTACs (1) Reactive Oxygen Species (1) Ser/Thr Protease (3) Survivin (1) TAM Receptor (1) Topoisomerase (1) Virus Protease (1)
By Research Areas:	Cancer (717) Cardiovascular Disease (12) Endocrinology (4) Infection (18) Inflammation/Immunology (38) Metabolic Disease (7) Neurological Disease (14)

By Targets:

ADC Linker (638)

Amino Acid Derivatives (1)

Androgen Receptor (2)

Angiotensin Receptor (2)

Antibiotic (3)

Antibody-Drug Conjugates (ADCs) (9)

Apoptosis (17)

Arenavirus (1)

Bacterial (6)

Beta-secretase (12)

Biochemical Assay Reagents (5)

Bradykinin Receptor (4)

Caspase (3)

Checkpoint Kinase (Chk) (1)

Complement System (1)

Deubiquitinase (1)

DNA/RNA Synthesis (1)

Drug-Linker Conjugates for ADC (46)

EGFR (3)

Endogenous Metabolite (10)

Fluorescent Dye (15)

GLUT (1)

HDAC (1)

Histone Methyltransferase (1)

Influenza Virus (1)

Integrin (1)

Keap1-Nrf2 (1)

Mas-related G-protein-coupled Receptor (MRGPR) (2)

MDM-2/p53 (1)

Microtubule/Tubulin (7)

MMP (3)

Notch (1)

Nucleoside Antimetabolite/Analog (1)

Orthopoxvirus (1)

PARP (2)

PGE synthase (1)

Phosphatase (1)

Phosphodiesterase (PDE) (5)

Phospholipase (1)

Poly(ADP-ribose) Glycohydrolase (PARG) (1)

PROTAC Linkers (208)

PROTACs (1)

Reactive Oxygen Species (1)

Ser/Thr Protease (3)

Survivin (1)

TAM Receptor (1)

Topoisomerase (1)

Virus Protease (1)

By Research Areas:

Cancer (717)

Cardiovascular Disease (12)

Endocrinology (4)

Infection (18)

Inflammation/Immunology (38)

Metabolic Disease (7)

Neurological Disease (14)

798

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-140920

UV Cleavable Biotin-PEG2-Azide
PROTAC Linkers Cancer

UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
HY-118759

DSP Crosslinker
ADC Linker Inflammation/Immunology

DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).
HY-139441

DM21
Drug-Linker Conjugates for ADC Cancer

DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-114697

DSG Crosslinker
ADC Linker Inflammation/Immunology

DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-147118

NHS-SS-Ph
ADC Linker Cancer

NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135418

Fmoc-Asp-NH2
ADC Linker Cancer

Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-117409

Aminoethyl-SS-ethylalcohol
ADC Linker Cancer

Aminoethyl-SS-ethylalcohol is a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-116270

DBCO-Maleimide
ADC Linker Cancer

DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-42973

DBCO-NHS ester
ADC Linker Cancer

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-131156

Mal-PEG2-Val-Cit-PABA-PNP
ADC Linker Cancer

Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140144

Mal-PEG1-Val-Cit-PAB-PNP
ADC Linker Cancer

Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-123687

DBCO-Sulfo-NHS ester sodium
ADC Linker Cancer

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-79129

Fmoc-D-Trp(Boc)-OH
ADC Linker Cancer

Fmoc-D-Trp(Boc)-OH is a cleavable ADC linker that used in the synthesis of antibody-drug conjugates (ADCs).

*UV Cleavable* Biotin-PEG2-Azide**	PROTAC Linkers	Cancer
UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DSP Crosslinker	ADC Linker	Inflammation/Immunology
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).

DM21	Drug-Linker Conjugates for ADC	Cancer
DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DSG Crosslinker	ADC Linker	Inflammation/Immunology
DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

NHS-SS-Ph	ADC Linker	Cancer
NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Asp-NH2	ADC Linker	Cancer
Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Aminoethyl-SS-ethylalcohol	ADC Linker	Cancer
Aminoethyl-SS-ethylalcohol is a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-Maleimide	ADC Linker	Cancer
DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-NHS ester	ADC Linker	Cancer
DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mal-PEG2-Val-Cit-PABA-PNP	ADC Linker	Cancer
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mal-PEG1-Val-Cit-PAB-PNP	ADC Linker	Cancer
Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-Sulfo-NHS ester sodium	ADC Linker	Cancer
DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-D-Trp(Boc)-OH	ADC Linker	Cancer
Fmoc-D-Trp(Boc)-OH is a cleavable ADC linker that used in the synthesis of antibody-drug conjugates (ADCs).

HY-41189

Fmoc-Val-Cit-PAB-PNP	ADC Linker	Cancer
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers.

HY-130810

DBCO-Sulfo-Link-biotin
ADC Linker Cancer

DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-148461

Mal-VC-PAB-PNP
ADC Linker Cancer

Mal-VC-PAB-PNP is a cleavable ADC linker (ADC Linker). Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).
HY-148463

MP-Ala-Ala-PAB
ADC Linker Cancer

MP-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).
HY-148462

Fmoc-Ala-Ala-PAB
ADC Linker Cancer

Fmoc-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).
HY-148464

MC-Ala-Ala-PAB
ADC Linker Cancer

MC-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-Sulfo-Link-biotin	ADC Linker	Cancer
DBCO-Sulfo-Link-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mal-VC-PAB-PNP	ADC Linker	Cancer
Mal-VC-PAB-PNP is a cleavable ADC linker (ADC Linker). Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

MP-Ala-Ala-PAB	ADC Linker	Cancer
MP-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Ala-Ala-PAB	ADC Linker	Cancer
Fmoc-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

MC-Ala-Ala-PAB	ADC Linker	Cancer
MC-Ala-Ala-PAB is a cleavable ADC linker (ADC Linker). Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-131157

Lys(MMT)-PAB-oxydiacetamide-PEG8-N3	ADC Linker	Cancer
Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody drug conjugate linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W040236

m-PEG8-Amine
ADC Linker PROTAC Linkers Cancer

m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-131990

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
ADC Linker Cancer

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126497

LC-PEG8-SPDP
ADC Linker Cancer

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).
HY-132261

AcBut
4-(4-Acetyl-phenoxy)-butyric acid
ADC Linker Cancer

AcBut is a cleavable Ozogamicin linker used in the synthesis of Ozogamicin, a drug-linker conjugate for ADC.
HY-126789

DM-Nitrophen
Others Others

DM-Nitrophen is a Ca²⁺ cage. DM-Nitrophen releases Ca²⁺ when cleaved upon illumination with near-ultraviolet light.

m-PEG8-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

LC-PEG8-SPDP	ADC Linker	Cancer
LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).

AcBut 4-(4-Acetyl-phenoxy)-butyric acid	ADC Linker	Cancer
AcBut is a cleavable Ozogamicin linker used in the synthesis of Ozogamicin, a drug-linker conjugate for ADC.

DM-Nitrophen	Others	Others
DM-Nitrophen is a Ca²⁺ cage. DM-Nitrophen releases Ca²⁺ when cleaved upon illumination with near-ultraviolet light.

HY-W044078

N-Boc-diethanolamine	ADC Linker PROTAC Linkers	Cancer
N-Boc-diethanolamine is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141597

Acid-C3-SSPy
ADC Linker Cancer

Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a drug-linker conjugate for ADC.

Acid-C3-SSPy	ADC Linker	Cancer
Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a drug-linker conjugate for ADC.

HY-130383

Propargyl-PEG7-acid	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130386

Propargyl-PEG6-acid	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141170

TCO-PEG12-NHS ester	ADC Linker PROTAC Linkers	Cancer
TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130457

m-PEG4-Ms	ADC Linker PROTAC Linkers	Cancer
m-PEG4-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-120237

m-PEG7-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG7-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141167

TCO-PEG4-NHS ester	ADC Linker PROTAC Linkers	Cancer
TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-116186

m-PEG5-Ms	ADC Linker PROTAC Linkers	Cancer
m-PEG5-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W040214

m-PEG4-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG4-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W008429

m-PEG2-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG2-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130571

m-PEG9-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG9-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-117031

m-PEG8-Ms	ADC Linker PROTAC Linkers	Cancer
m-PEG8-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W040222

m-PEG11-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126974

Propargyl-PEG3-NHS ester	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130388

Propargyl-PEG5-NHS ester	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126889

Bis-PEG5-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130825

Bis-PEG13-NHS ester	PROTAC Linkers ADC Linker	Cancer
Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130381

Propargyl-PEG7-NHS ester	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130827

Bis-PEG21-NHS ester	PROTAC Linkers ADC Linker	Cancer
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG21-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130385

Propargyl-PEG6-NHS ester	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130826

Bis-PEG17-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130828

Bis-PEG25-NHS ester	PROTAC Linkers ADC Linker	Cancer
Bis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130376

Propargyl-PEG8-NHS ester	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126890

Bis-PEG7-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130824

Bis-PEG10-NHS ester	PROTAC Linkers ADC Linker	Cancer
Bis-PEG10-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG10-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-131955

Fmoc-aminooxy-PEG2-NH2
ADC Linker Cancer

Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-132252

Mal-PEG8-Val-Ala-PABC
ADC Linker Cancer

Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a drug-linker conjugate for ADC.

HY-120702

N-Boc-PEG5-bromide	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W006445

N-Boc-PEG3-bromide	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG3-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG3-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130505

N-Boc-PEG7-alcohol	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG7-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG7-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W071584

N-Boc-PEG6-alcohol	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W046471

N-Boc-PEG4-bromide	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130503

N-Boc-PEG2-bromide	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG2-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG2-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W071583

N-Boc-PEG9-alcohol	ADC Linker PROTAC Linkers	Cancer
N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130222

Mal-PEG2-Val-Cit-PAB-OH	ADC Linker PROTAC Linkers	Cancer
Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

HY-130449

N-Boc-N-bis(PEG4-OH)	ADC Linker PROTAC Linkers	Cancer
N-Boc-N-bis(PEG4-OH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-117519A

Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride	ADC Linker PROTAC Linkers	Cancer
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-117079

N-Boc-N-bis(PEG2-OH)	ADC Linker PROTAC Linkers	Cancer
N-Boc-N-bis(PEG2-OH) is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG2-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-101162

SGD-1910	Drug-Linker Conjugates for ADC	Cancer
SGD-1910 is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala.

HY-117519

Amino-Tri-(carboxyethoxymethyl)-methane	ADC Linker PROTAC Linkers	Cancer
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140927

Azido-C3-UV-biotin
UV cleavable Biotin-PEG2-alkyne
PROTAC Linkers Cancer

Azido-C3-UV-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-141395

m-PEG4-Boc	ADC Linker PROTAC Linkers	Cancer
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-21577

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine	ADC Linker PROTAC Linkers	Cancer
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel.

HY-130690

Propargyl-PEG1-SS-PEG1-C2-Boc	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG1-SS-PEG1-C2-Boc is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-146125

CGCG/CGG ligand 1	Others	Metabolic Disease
CGCG/CGG ligand 1 (compound 10), an anthracenone derivative, is a CGCG or CGG short spacer-ligand. CGCG/CGG ligand 1 can protect cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme.

HY-P3159A

VPM peptide TFA	Biochemical Assay Reagents	Others
VPM peptide TFA is a dithiol protease-cleavable peptide cross-linker. VPM peptide TFA can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel.

HY-140150

Azido-PEG3-Val-Cit-PAB-PNP	ADC Linker PROTAC Linkers	Cancer
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140149

Azido-PEG4-Val-Cit-PAB-OH	ADC Linker PROTAC Linkers	Cancer
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126789A

DM-Nitrophen tertasodium	Others	Others
DM-Nitrophen tertasodium is a Ca²⁺ cage. DM-Nitrophen releases Ca²⁺ when cleaved upon illumination with near-ultraviolet light. DM-Nitrophen tertasodium can be used for study of Ca²⁺ signaling.

HY-130194

Azido-PEG5-CH2CO2H	ADC Linker PROTAC Linkers	Cancer
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126350

CL2-SN-38	Drug-Linker Conjugates for ADC	Cancer
CL2-SN-38 is a cleavable linker-based Drug-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer.

HY-114816

N-Butanoyl-L-homoserine lactone C4-HSL; N-Butyryl-L-homoserine lactone	ADC Linker Bacterial	Infection Inflammation/Immunology
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

HY-130474

Azido-PEG6-NHS ester	ADC Linker PROTAC Linkers	Cancer
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130184

Azido-PEG8-NHS ester	ADC Linker PROTAC Linkers	Cancer
Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130379

Propargyl-PEG8-acid	ADC Linker PROTAC Linkers Bacterial	Cancer Infection
Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria.

HY-42618

Azido-PEG4-CH2-Boc	ADC Linker PROTAC Linkers	Cancer
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126894

Bis-PEG9-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126893

Bis-PEG8-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126892

Bis-PEG7-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-118808

Propargyl-PEG2-NHBoc	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-130387

Propargyl-PEG4-Tos	PROTAC Linkers ADC Linker	Cancer
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-42489

N3-PEG3-CH2CH2-Boc	ADC Linker PROTAC Linkers	Cancer
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-145951

Amidate-VC-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs.

HY-130435

DBCO-PEG4-amine	ADC Linker PROTAC Linkers	Cancer
DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker).

HY-145736A

β-Glucuronide-dPBD-PEG5-NH2 TFA	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity.

HY-145736

β-Glucuronide-dPBD-PEG5-NH2	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity.

HY-133231

Bis-PEG10-acid
PROTAC Linkers Cancer

Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
HY-145735

Allyl (2-aminoethyl)carbamate
ADC Linker Others

Allyl (2-aminoethyl)carbamate is a cleavable linker.
HY-12362

Val-cit-PAB-OH
ADC Linker Cancer

Val-cit-PAB-OH is a cleavable ADC linker.
HY-W098764

Allyl (2-aminoethyl)carbamate hydrochloride
ADC Linker Others

Allyl (2-aminoethyl)carbamate hydrochloride is a cleavable linker.
HY-129377

Sulfo-SPP
ADC Linker Cancer

Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
HY-129377A

Sulfo-SPP sodium
ADC Linker Cancer

Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
HY-126503

trans-Sulfo-SMCC
ADC Linker Cancer

trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker.
HY-126495

Sulfo-LC-SPDP
ADC Linker Cancer

Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
HY-129365

SNPB
ADC Linker Cancer

SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
HY-129376

Sulfo-SNPB
ADC Linker Cancer

Sulfo-SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
HY-19318

Fmoc-Val-Cit-PAB
ADC Linker Cancer

Fmoc-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).
HY-126519

PDdEC-NB
ADC Linker Cancer

PDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).

HY-100216

SPDP SPDP Crosslinker	ADC Linker	Cancer
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).

HY-W016887

H-Gly-Pro-OH
Endogenous Metabolite Metabolic Disease

H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
HY-129366

PDB-Pfp
ADC Linker Cancer

PDB-Pfp is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129375

SNPB-sulfo-Me
ADC Linker Cancer

SNPB-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).
HY-44235

MC-Gly-Gly-Phe
ADC Linker Cancer

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).
HY-129373

SPDMV-sulfo
ADC Linker Cancer

SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
HY-126667

SC-Val-Cit-PAB
ADC Linker Cancer

SC-Val-Cit-PAB is a cleavable ADC linker for antibody-drug conjugates (ADCs).
HY-126498

PDEC-NB
ADC Linker Cancer

PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).
HY-129369

SPDMB
ADC Linker Cancer

SPDMB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
HY-12448

SPDB
ADC Linker Cancer

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
HY-129361

Fmoc-Ala-Ala-Asn-PABC-PNP
ADC Linker Cancer

Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker.
HY-129368

SPDMV
ADC Linker Cancer

SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
HY-126530

PPC-NB
ADC Linker Cancer Cardiovascular Disease

PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC).

HY-133540

Maleimide-DOTA Maleimido-mono-amide-DOTA	ADC Linker	Cancer Inflammation/Immunology
Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-129370

SPDB-sulfo
ADC Linker Cancer

SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
HY-129371

SPDV
ADC Linker Cancer

SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.
HY-128927

Mc-Leu-Gly-Arg
ADC Linker Cancer

Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.
HY-129374

SPDH
ADC Linker Cancer

SPDH is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas.
HY-78931

Boc-Dap-NE
ADC Linker Cancer

Boc-Dap-NE, a dipeptide, is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136095

Tetrazine-biotin
ADC Linker Cancer

Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-150043A

MDTF
ADC Linker Cancer

MDTF is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130111

DMAC-SPP
ADC Linker Cancer

DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-44246

MC-Gly-Gly-Phe-Gly
ADC Linker Cancer

MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
HY-140014

Val-Cit
ADC Linker Cancer

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-101151

sulfo-SPDB
ADC Linker Cancer

sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-139682

Dovitinib-RIBOTAC
PROTACs Cancer

Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.
HY-19318A

Fmoc-Val-D-Cit-PAB
ADC Linker Cancer

Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).
HY-126349

DTSSP Crosslinker
ADC Linker Cancer

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140098

Boc-Cystamine
ADC Linker Cancer

Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129353

Boc-Phe-(Alloc)Lys-PAB-PNP
ADC Linker Cancer

Boc-Phe-(Alloc)Lys-PAB-PNP is a used as a cleavable linker for antibody-drug conjugates (ADC).
HY-126496

PEG4-SPDP
ADC Linker Cancer

PEG4-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs).
HY-129367

NO2-SPP
ADC Linker Cancer

NO2-SPP is a cleavable linker that is used for making antibody-drug conjugate (ADC).
HY-133550

DMAC-SPDB
ADC Linker Cancer

DMAC-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-19318B

Fmoc-D-Val-Cit-PAB
ADC Linker Cancer

Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).
HY-79584

Propargyl-Tos
ADC Linker Cancer

Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126405

SMPT
ADC Linker Cancer

SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129352

Cbz-Phe-(Alloc)Lys-PAB-PNP
ADC Linker Cancer

Cbz-Phe-(Alloc)Lys-PAB-PNP is an cleavable linker for antibody-drug conjugates (ADC) design.
HY-P3950

Fluorescent Substrate for Asp-Specific Proteases
Fluorescent Dye Others

Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond.
HY-133542

Dimethylamine-SPDB
ADC Linker Cancer

Dimethylamine-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126531

DMAC-PDB
ADC Linker Cancer

DMAC-PDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136104

Methyltetrazine-Maleimide
ADC Linker Cancer

Methyltetrazine-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W000423

DBCO-amine
ADC Linker Cancer

DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W071006

PPC-NHS ester 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate	ADC Linker	Cancer
PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133543

SPDP-sulfo
ADC Linker Cancer

SPDP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-20560

(Ac)Phe-Lys(Alloc)-PABC-PNP
ADC Linker Cancer

(Ac)Phe-Lys(Alloc)-PABC-PNP is an useful cleavable chemical linker in antibody drug conjugates.
HY-128926

SPP
ADC Linker Cancer

SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate.

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-136033

Methyltetrazine-SS-NHS
ADC Linker Cancer

Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140987

5-Maleimidovaleric acid
ADC Linker Cancer

5-Maleimidovaleric acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140313

Methyltetrazine-DBCO
ADC Linker Cancer

Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130110

Sulfo-DMAC-SPP
ADC Linker Cancer

Sulfo-DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140306

Mal-Sulfo-DBCO
ADC Linker Cancer

Mal-Sulfo-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W019543

DSS Crosslinker
ADC Linker Cancer

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140105

Azidoethyl-SS-ethylazide
ADC Linker Cancer

Azidoethyl-SS-ethylazide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141158

N-(Iodoacetamido)-Doxorubicin
ADC Linker Cancer

N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136031

Tetrazine-SS-Biotin
ADC Linker Cancer

Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140100

Azidoethyl-SS-propionic acid
ADC Linker Cancer

Azidoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140296

BDP FL DBCO
ADC Linker Cancer

BDP FL DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-138327

1,6-Bis(mesyloxy)hexane
ADC Linker Cancer

16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135973

BCN-SS-NHS
ADC Linker Cancer

BCN-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136032

Tetrazine-SS-NHS
ADC Linker Cancer

Tetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135978

DBCO-SS-amine
ADC Linker Cancer

DBCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135972

BCN-SS-amine
ADC Linker Cancer

BCN-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140096

Aminoethyl-SS-propionic acid
ADC Linker Cancer

Aminoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126851

Fluorescein-DBCO
ADC Linker Cancer

Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126518

Cyclooctyne-O-PFP ester
ADC Linker Cancer

Cyclooctyne-O-PFP ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W096127

Biotin-sar-oh
ADC Linker Cancer

Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130928

Tetrazine-Ph-OPSS
ADC Linker Cancer

Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-128929

Fmoc-PEA
ADC Linker Cancer

Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
HY-140122

THP-SS-alcohol
ADC Linker Cancer

THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1484

Bradykinin (1-7) Bradykinin Fragment 1-7	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

HY-140104

Azidoethyl-SS-ethylamine
ADC Linker Cancer

Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-19318C

Fmoc-D-Val-D-Cit-PAB
ADC Linker Cancer

Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).
HY-138506

DBCO-S-S-acid
ADC Linker Cancer

DBCO-S-S-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129360

Ala-Ala-Asn-PAB
ADC Linker Cancer

Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs).
HY-126517

Cyclooctyne-O-NHS ester
ADC Linker Cancer

Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135977

DBCO-SS-aldehyde
ADC Linker Cancer

DBCO-SS-aldehyde is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-131084

DMAC-SPDB-sulfo
ADC Linker Cancer

DMAC-SPDB-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W011541

SIA Crosslinker
ADC Linker Cancer

SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W002213

N-Hydroxysulfosuccinimide sodium
ADC Linker Cancer

N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140129

NHS-SS-biotin
ADC Linker Cancer

NHS-SS-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136039

TCO-SS-amine
ADC Linker Cancer

TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-150043

MDTF free acid
ADC Linker Cancer

MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-135859

NH2-MPAA-NODA	ADC Linker	Cancer
NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone. NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-130112

N-Succinimidyloxycarbonylpropyl methanethiosulfonate NHS-C4-MTS	ADC Linker	Cancer
N-Succinimidyloxycarbonylpropyl methanethiosulfonate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-124329

BS3 Crosslinker
ADC Linker Cancer

BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130935

DBCO-Val-Cit-OH
ADC Linker Cancer

DBCO-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-101153

MC-Val-Ala-OH
ADC Linker Cancer

MC-Val-Ala-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126364

Mc-Val-Ala-PAB
ADC Linker Cancer

Mc-Val-Ala-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140138

PC SPDP-NHS carbonate ester
ADC Linker Cancer

PC SPDP-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W097109A

Fmoc-(D-Phe)-OSu
ADC Linker Cancer

Fmoc-(D-Phe)-Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136102

Py-ds-Prp-Osu
ADC Linker Cancer

Py-ds-Prp-Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140102

Azidoethyl-SS-propionic NHS ester
ADC Linker Cancer

Azidoethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W023121

Fmoc-Gly-Gly-OH
ADC Linker Cancer

Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141141

Boc-Val-Cit-PAB
ADC Linker Cancer

Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1032

Angiotensin I (human, mouse, rat)	Endogenous Metabolite	Others
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

HY-140140

PC Mal-NHS carbonate ester
ADC Linker Cancer

PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-138322

N-trifluoroacetyl-β-alanyl chloride
ADC Linker Cancer

N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129362

Phe-Lys(Fmoc)-PAB
ADC Linker Cancer

Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs).

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-138387

6-Azido-hexylamine
ADC Linker Cancer

6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129349

Phe-Lys(Trt)-PAB
ADC Linker Cancer

Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs).
HY-78738

MC-Val-Cit-PAB
ADC Linker Cancer

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate.
HY-W038702

Boc-Val-Cit-OH
ADC Linker Cancer

Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133504

Tetrazine-Ph-SS-amine
ADC Linker Cancer

Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-114430

Fmoc-Phe-Lys(Boc)-PAB-PNP
ADC Linker Others

Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130956

Boc-NMe-Val-Val-Dil-Dap-OH
ADC Linker Cancer

Boc-NMe-Val-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126353

Fmoc-Val-Ala-PAB-OH
ADC Linker Cancer

Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-44234

Fmoc-Gly-Gly-Phe-OtBu
ADC Linker Cancer

Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140116

Boc-NH-ethyl-SS-propionic acid
ADC Linker Cancer

Boc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-124329A

BS3 Crosslinker disodium
ADC Linker Cancer

BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130937

DBCO-Val-Cit-PABC-PNP
ADC Linker Cancer

DBCO-Val-Cit-PABC-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133412

DBCO-NHCO-S-S-NHS ester
ADC Linker Cancer

DBCO-NHCO-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130961

Boc-Val-Dil-Dap-OH
ADC Linker Cancer

Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130936

DBCO-Val-Cit-PABC-OH
ADC Linker Cancer

DBCO-Val-Cit-PABC-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141145

OPSS-Val-Cit-PAB-PNP
ADC Linker Cancer

OPSS-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-44222

MAC glucuronide linker-2
ADC Linker Cancer

MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130932

Boc-Val-Ala-PAB-PNP
ADC Linker Cancer

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136136

Fmoc-Val-Ala-PAB-PNP
ADC Linker Cancer

Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140118

Fmoc-NH-ethyl-SS-propionic acid
ADC Linker Cancer

Fmoc-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133413

DBCO-CONH-S-S-NHS ester
ADC Linker Cancer

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126533

PDP-C1-Ph-Val-Cit
ADC Linker Cancer

PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
HY-131833

Fmoc-Gly-Gly-Phe-OH
ADC Linker Cancer

Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141144

OPSS-Val-Cit-PAB-OH
ADC Linker Cancer

OPSS-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126670

mDPR(Boc)-Val-Cit-PAB
ADC Linker Cancer

mDPR(Boc)-Val-Cit-PAB is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
HY-141142

Boc-Val-Cit-PAB-PNP
ADC Linker Cancer

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-139353

Fmoc-Phe-Lys(Boc)-PAB
ADC Linker Cancer

Fmoc-Phe-Lys(Boc)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140117

Boc-aminooxy-ethyl-SS-propanol
ADC Linker Cancer

Boc-aminooxy-ethyl-SS-propanol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-138745

Bis-sulfone-PEG3-Azide
ADC Linker Cancer

Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130930

Acid-propionylamino-Val-Cit-OH
ADC Linker Cancer

Acid-propionylamino-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140120

Mal-NH-ethyl-SS-propionic acid
ADC Linker Cancer

Mal-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140125

2-Hydroxyethyl disulfide mono-tosylate
ADC Linker Cancer

2-Hydroxyethyl disulfide mono-tosylate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-132251

MCC
ADC Linker Cancer

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1.
HY-136139

3-Azidopropionic Acid Sulfo-NHS ester
ADC Linker Cancer

3-Azidopropionic Acid Sulfo-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136107

Fmoc-Phe-Lys(Trt)-PAB
ADC Linker Cancer

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135975

MC-Val-Ala-PAB-PNP
ADC Linker Cancer

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W071007

NO2-SPDMV
ADC Linker Cancer

NO2-SPDMV is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-139856

Mal-Ala-Ala-PAB-PNP
ADC Linker Cancer

Mal-Ala-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-E70018

Picornain 3C	Endogenous Metabolite	Infection Metabolic Disease
Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses.

HY-133547

NO2-SPP-sulfo
ADC Linker Cancer

NO2-SPP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-112295

AzKTB
Biochemical Assay Reagents Infection

AzKTB is a capture reagent which bears a short trypsin-cleavable peptide sequence between the azide module and the TAMRA/PEG-biotin labels.
HY-129351

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
ADC Linker Cancer

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133548

NO2-SPDB-sulfo
ADC Linker Cancer

NO2-SPDB-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-78921

Fmoc-3VVD-OH
ADC Linker Cancer

Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130976

N-Boc-Val-Dil-Dap-Doe
ADC Linker Cancer

N-Boc-Val-Dil-Dap-Doe is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136132

MC-VC-PAB-NH2
ADC Linker Cancer

MC-VC-PAB-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136547

Boc-Val-Ala-PAB
ADC Linker Others

Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs).
HY-129350

Fmoc-Phe-Lys(Trt)-PAB-PNP
ADC Linker Cancer

Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130547

BS2G Crosslinker disodium
ADC Linker Cancer

BS2G Crosslinker (disodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129378

NO2-SPP-sulfo-Me
ADC Linker Cancer

NO2-SPP-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).
HY-136125

BCOT-PEF3-OPFP
ADC Linker Cancer

BCOT-PEF3-OPFP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133549

NO2-SPDMV-sulfo
ADC Linker Cancer

NO2-SPDMV-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-128940

EC089
ADC Linker Cancer

EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1.
HY-138521

Azido-C6-OH
ADC Linker Cancer

Azido-C6-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1469

Bradykinin (1-6)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).

HY-130975

Boc-Val-Dil-Dap-Phe-OMe
ADC Linker Cancer

Boc-Val-Dil-Dap-Phe-OMe is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140119

Fmoc-NH-ethyl-SS-propionic NHS ester
ADC Linker Cancer

Fmoc-NH-ethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-120770

DBCO-PEG4-Maleimide
ADC Linker Cancer

DBCO-PEG4-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W011561

Boc-NH-C6-Br
ADC Linker Cancer

Boc-NH-C6-Br is a non-cleavable linker used for antibody-drug conjugates (ADC).
HY-130933

Fmoc-Ala-Ala-Asn(Trt)-OH
ADC Linker Cancer

Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-148194

SC239
ADC Linker Cancer

SC239 is a cleavable 2-aminophenyl hemiasterlin drug-linker. SC239 can be as the drug-linker for ADC.
HY-138535

Azide-C2-Azide
ADC Linker Cancer

Azide-C2-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136329

β-D-glucuronide-pNP-carbonate
ADC Linker Cancer

β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1497

Bradykinin (1-3)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

HY-151740

4-Pentynoyl-Val-Ala-PAB-PNP
ADC Linker Others

4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates.
HY-136154

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
ADC Linker Cancer

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141143

MC(C5)-Val-Cit
ADC Linker Cancer

MC(C5)-Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126495A

Sulfo-SPDP-C6-NHS sodium
ADC Linker Cancer

Sulfo-SPDP-C6-NHS sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-145488

MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D	ADC Linker	Cancer
MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-138651

PAB-Val-Lys-Boc	ADC Linker	Inflammation/Immunology
PAB-Val-Lys-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) for stimulating an immune response.

HY-133584

Bis-SS-C3-NHS ester
ADC Linker Cancer

Bis-SS-C3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-145593

Aminooxy-PEG2-BCN
ADC Linker Cancer

Aminooxy-PEG2-BCN is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-139107

Biotin-PEG4-SS-azide
ADC Linker Cancer

Biotin-PEG4-SS-azide is a cleavable, biotin-labeled, ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140126

Bis-Tos-(2-hydroxyethyl disulfide)
ADC Linker Cancer

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-108910

Chymotrypsin Chymotrypsin A	Ser/Thr Protease	Others
Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids.

HY-118119

CAY10526	PGE synthase	Cancer
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC₅₀<5 μM) in three melanoma cell lines expressing mPGES1.

HY-145066

Gly-Gly-Gly-PEG4-azide
ADC Linker Cancer

Gly-Gly-Gly-PEG4-azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141355

OPSS-PEG36-acid
ADC Linker Cancer

OPSS-PEG36-acid is a cleavable 36 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126505

Mal-PEG4-NHS ester
ADC Linker Cancer

Mal-PEG4-NHS ester is a non-cleavable ADC linker which links Quantum dots (QDs) with PEGylated liposomes.

HY-131086

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2	ADC Linker	Cancer Inflammation/Immunology
Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126883

Tr-PEG4-OH
PROTAC Linkers Cancer Inflammation/Immunology

Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-145489

Mal-PEG2-Val-Cit-PABA
ADC Linker Cancer

Mal-PEG2-Val-Cit-PABA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136106

Fmoc-Gly3-Val-Cit-PAB
ADC Linker Cancer

Fmoc-Gly3-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-21242

MMT-Hexylaminolinker Phosphoramidite	Others	Others
MMT-Hexylaminolinker Phosphoramidite is a cleavable linker. MMT-Hexylaminolinker Phosphoramidite can be used to syntheses oligonucleotide gapmers or other nucleic acid molecules.

HY-136432

Mc-Gly-Gly-Phe-Gly-PAB-OH
Mc-GGFG-PAB-OH
ADC Linker Cancer

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
HY-148550

MC-PEG2-NH2
ADC Linker Cancer

MC-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141123

SPDP-C6-Gly-Leu-NHS ester
ADC Linker Cancer

SPDP-C6-Gly-Leu-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133408

4-Methyl-4-(methyldisulfanyl)pentanoic acid	ADC Linker	Cancer
4-Methyl-4-(methyldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-129311

Tr-PEG6-OH
ADC Linker Cancer Inflammation/Immunology

Tr-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133585

Bis-SS-C3-sulfo-NHS ester
ADC Linker Cancer

Bis-SS-C3-sulfo-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-145367

Ala-CO-amide-C4-Boc
ADC Linker Cancer

Ala-CO-amide-C4-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-120258

Tr-PEG3-OH
ADC Linker Cancer Inflammation/Immunology

Tr-PEG3-OH is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-115374

m-PEG6-azide
ADC Linker Cancer Inflammation/Immunology

m-PEG6-azide is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141353

SPDP-PEG12-acid
ADC Linker Cancer

SPDP-PEG12-acid is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135971

BCN-PEG4-acid
ADC Linker Cancer

BCN-PEG4-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W019793

m-PEG8-NHS ester
ADC Linker Cancer Inflammation/Immunology

m-PEG8-NHS ester is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136051

Biotin-PEG3-aldehyde
ADC Linker Cancer

Biotin-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1449

Boc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-136099

Bocaminooxyacetamide-PEG2-Azido
ADC Linker Cancer

Bocaminooxyacetamide-PEG2-Azido is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136044

APN-PEG4-BCN
ADC Linker Cancer

APN-PEG4-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136309

Ald-PEG23-SPDP
ADC Linker Cancer

Ald-PEG23-SPDP is a cleavable 23 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140115

Bis-(PEG6-acid)-SS
ADC Linker Cancer

Bis-(PEG6-acid)-SS is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136052

Tetrazine-PEG4-oxyamine hydrochloride	ADC Linker	Cancer
Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-138484

Folate-PEG3-amine
ADC Linker Cancer

Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135961

PTAD-PEG4-amine
ADC Linker Cancer

PTAD-PEG4-amine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136086

Tetrazine-PEG6-amine hydrochloride	ADC Linker	Cancer
Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-148211

Tetrazine-PEG7-amine hydrochloride
ADC Linker Cancer

Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136049

APN-PEG4-DBCO
ADC Linker Cancer

APN-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-116655

Hydroxy-PEG1-acid
ADC Linker Cancer

Hydroxy-PEG1-acid is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W096133

Biotin-PEG1-azide
ADC Linker Cancer

Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135974

Amino-PEG3-SS-acid
ADC Linker Cancer

Amino-PEG3-SS-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140244

Gly-PEG3-amine
ADC Linker Cancer

Gly-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136046

PTAD-PEG4-alkyne
ADC Linker Cancer

PTAD-PEG4-alkyne is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140097

Amino-SS-PEG12-acid
ADC Linker Cancer

Amino-SS-PEG12-acid is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136045

APN-PEG4-tetrazine
ADC Linker Cancer

APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136067

DBCO-PEG4-HyNic
ADC Linker Cancer

DBCO-PEG4-HyNic is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136048

Methylcyclopropene-PEG4-NHS
ADC Linker Cancer

Methylcyclopropene-PEG4-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136127

ALD-PEG4-OPFP
ADC Linker Cancer

ALD-PEG4-OPFP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-138488

Biotin-PEG4-PFP ester
ADC Linker Cancer

Biotin-PEG4-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136077

TCO-PEG3-aldehyde
ADC Linker Cancer

TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136061

BCN-PEG4-HyNic
ADC Linker Cancer

BCN-PEG4-HyNic is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135964

(2-pyridyldithio)-PEG4 acid
ADC Linker Cancer

(2-pyridyldithio)-PEG4 acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136050

TCO-PEG3-Biotin
ADC Linker Cancer

TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136075

HyNic-PEG4-alkyne
ADC Linker Cancer

HyNic-PEG4-alkyne is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-116063

Doxorubicin-SMCC	Drug-Linker Conjugates for ADC	Cancer
Doxorubicin-SMCC is a drug-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin.

HY-136047

Methylcyclopropene-PEG3-amine
ADC Linker Cancer

Methylcyclopropene-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W011165

L-Lysyl-L-lysine dihydrochloride Lysyllysine dihydrochloride	Others	Others
L-Lysyl-L-lysine (Lysyllysine) dihydrochloride is an enzyme cleavable basic amino acid. L-Lysyl-L-lysine dihydrochloride can be used for delivering multiple biologically active peptides.

HY-136101

Bocaminooxyacetamide-PEG3-alkyne
ADC Linker Cancer

Bocaminooxyacetamide-PEG3-alkyne is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136074

Methyltetrazine-PEG4-aldehyde
ADC Linker Cancer

Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141358

SPDP-PEG36-NHS ester
ADC Linker Cancer

SPDP-PEG36-NHS ester is a cleavable 36 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130939

APN-PEG4-Amine hydrochloride
ADC Linker Cancer

APN-PEG4-Amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-132163

MP-PEG4-VK(Boc)G-OSu
ADC Linker Cancer

MP-PEG4-VK(Boc)G-OSu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136053

Tetrazine-PEG4-biotin
ADC Linker Cancer

Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130977

Tetrazine-PEG4-amine hydrochloride	ADC Linker	Cancer
Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140352

Azide-PEG5-Tos
ADC Linker Cancer

Azide-PEG5-Tos is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136038

Azido-PEG3-SSPy
ADC Linker Cancer

Azido-PEG3-SSPy is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136432A

Mc-Gly-Gly-Phe-Gly-PAB-OH TFA
Mc-GGFG-PAB-OH TFA
ADC Linker Cancer

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) TFA is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
HY-132086

(2-Pyridyldithio)-PEG6 acid
ADC Linker Cancer

2-Pyridyldithio-PEG6 acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136056

Methyltetrazine-PEG4-oxyamine
ADC Linker Cancer

Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W034595

Eicosanedioic acid	ADC Linker PROTAC Linkers	Cancer
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-130925

BCN-PEG4-OH
ADC Linker Cancer

BCN-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140078

bis-PEG2-endo-BCN
ADC Linker Cancer

bis-PEG2-endo-BCN is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133431

DBCO-PEG3-SS-NHS ester
ADC Linker Cancer

DBCO-PEG3-SS-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135962

Boc-Aminooxy-PEG2-bromide
ADC Linker Cancer

Boc-Aminooxy-PEG2-bromide is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140124

THP-SS-PEG1-Tos
ADC Linker Cancer

THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130924

BCN-PEG3-Biotin
ADC Linker Cancer

BCN-PEG3-Biotin is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135966

Azido-PEG3-SS-NHS
ADC Linker Cancer

Azido-PEG3-SS-NHS is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130926

BCN-PEG3-oxyamine
ADC Linker Cancer

BCN-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136041

Boc-amino-PEG3-SSPy
ADC Linker Cancer

Boc-amino-PEG3-SSPy is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140130

PC Biotin-PEG3-alkyne
ADC Linker Cancer

PC Biotin-PEG3-alkyne is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140123

THP-SS-PEG1-Boc
ADC Linker Cancer

THP-SS-PEG1-Boc is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130927

BCN-PEG4-Ts
ADC Linker Cancer

BCN-PEG4-Ts is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133466

Methyltetrazine-PEG4-SS-NHS ester
ADC Linker Cancer

Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140108

Propargyl-PEG1-SS-alcohol
ADC Linker Cancer

Propargyl-PEG1-SS-alcohol is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136035

Methyltetrazine-SS-PEG4-Biotin
ADC Linker Cancer

Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-15934

X-GAL BCIG	Fluorescent Dye	Others
X-GAL is a widely used chromogenic β-galactosidase substrate. β-galactosidase cleaves X-gal and produce an insoluble blue compound, which is detectable.

HY-133434

Aminoxyacetamide-PEG3-azide
ADC Linker Cancer

Aminoxyacetamide-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133428

DBCO-PEG3-TCO
ADC Linker Cancer

DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P1449A

Boc-Gly-Gly-Phe-Gly-OH TFA	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-136096

DBCO-PEG3 acetic-EVCit-PAB
ADC Linker Cancer

DBCO-PEG3 acetic-EVCit-PAB is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133430

DBCO-PEG4-alkyne
ADC Linker Cancer

DBCO-PEG4-alkyne is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-112561

Bis-PEG1-PFP ester
ADC Linker Cancer Inflammation/Immunology

Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130955

Amino-bis-PEG3-TCO
ADC Linker Cancer

Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140134

PC Biotin-PEG3-NHS ester
ADC Linker Cancer

PC Biotin-PEG3-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140152

BCN-PEG3-VC-PFP ester
ADC Linker Cancer

BCN-PEG3-VC-PFP ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136078

Tetrazine-diazo-PEG4-biotin
ADC Linker Cancer

Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133432

DBCO-PEG4-SS-TCO
ADC Linker Cancer

DBCO-PEG4-SS-TCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-148425

Mal-amide-PEG8-Val-Ala-PAB-PNP
ADC Linker Cancer

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130945

Tetrazine-PEG5-SS-amine
ADC Linker Cancer

Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130972

Amino-bis-PEG3-DBCO
ADC Linker Cancer

Amino-bis-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136087

Mal-bis-PEG3-DBCO
ADC Linker Cancer

Mal-bis-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136079

Methyltetrazine-PEG4-hydrazone-DBCO	ADC Linker	Cancer
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140139

PC Alkyne-PEG4-NHS ester
ADC Linker Cancer

PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136040

Tetrazine-PEG4-SS-NHS
ADC Linker Cancer

Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136085

Amino-bis-PEG3-BCN
ADC Linker Cancer

Amino-bis-PEG3-BCN is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136097

Maleimide-PEG2-hydrazide TFA
ADC Linker Cancer

Maleimide-PEG2-hydrazide (TFA) is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140930

Diazo Biotin-PEG3-DBCO
ADC Linker Cancer

Diazo Biotin-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136036

Tetrazine-SS-PEG4-Biotin
ADC Linker Cancer

Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133427

Propargyl-PEG4-hydrazide
ADC Linker Cancer

Propargyl-PEG4-hydrazide is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133429

DBCO-PEG3-oxyamine
ADC Linker Cancer

DBCO-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136037

Boc-amino-PEG3-SS-acid
ADC Linker Cancer

Boc-amino-PEG3-SS-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140944

Biotin-PEG3-SS-azide
ADC Linker Cancer

Biotin-PEG3-SS-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140132

PC Biotin-PEG3-azide
ADC Linker Cancer

PC Biotin-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130947

Tetrazine-PEG4-SS-Py
ADC Linker Cancer

Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-138508

Biotin-PEG2-methyl ethanethioate
ADC Linker Cancer

Biotin-PEG2-methyl ethanethioate is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140136

PC DBCO-PEG3-biotin
ADC Linker Cancer

PC DBCO-PEG3-biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135979

DBCO-SS-PEG4-Biotin
ADC Linker Cancer

DBCO-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130934

TCO-PEG1-Val-Cit-OH
ADC Linker Cancer

TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140309

Gly-Gly-Gly-PEG4-DBCO
ADC Linker Cancer

Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141190

Gly-Gly-Gly-PEG3-TCO
ADC Linker Cancer

Gly-Gly-Gly-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141292

Oleoyl-Gly-Lys-N-(m-PEG11)
ADC Linker Cancer

Oleoyl-Gly-Lys-N-(m-PEG11) is a cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136134

SS-bis-amino-PEG4-NHS ester
ADC Linker Cancer

SS-bis-amino-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136034

Azido-PEG1-Val-Cit-OH
ADC Linker Cancer

Azido-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W096135

Biotin-PEG1-NH2
ADC Linker Cancer

Biotin-PEG1-NH2 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136135

(2-pyridyldithio)-PEG1-hydrazine
ADC Linker Cancer

(2-pyridyldithio)-PEG1-hydrazine is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133544

Mal-CO-PEG5-NHS ester
ADC Linker Cancer

Mal-CO-PEG5-NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130940

PTAD-PEG4-N3
ADC Linker Cancer

PTAD-PEG4-N3 is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130922

BCN-PEG1-Val-Cit-OH
ADC Linker Cancer

BCN-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140127

Azide-C2-SS-C2-biotin
ADC Linker Cancer

Azide-C2-SS-C2-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140099

Amino-ethyl-SS-PEG3-NHBoc
ADC Linker Cancer

Amino-ethyl-SS-PEG3-NHBoc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141284

Gly-Gly-Gly-PEG4-methyltetrazine
ADC Linker Cancer

Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133435

Aminooxy-amido-PEG4-propargyl
ADC Linker Cancer

Aminooxy-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133538

4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene	ADC Linker	Cancer
4-Succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136141

DBCO-PEG3-propionic EVCit-PAB
ADC Linker Cancer

DBCO-PEG3-propionic EVCit-PAB is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133459

Mal-PEG1-Val-Cit-OH
ADC Linker Cancer

Mal-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130962

Ald-Ph-amido-PEG23-OPSS
ADC Linker Cancer

Ald-Ph-amido-PEG23-OPSS is a cleavable 23 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130954

Hynic-PEG3-N3
ADC Linker Cancer

Hynic-PEG3-N3 is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130941

Fmoc-N-bis-PEG3-NH-Boc
ADC Linker Cancer

Fmoc-N-bis-PEG3-NH-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140145

Mal-PEG4-Val-Cit-PAB-PNP
ADC Linker Cancer

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136137

Azide-PEG1-Val-Cit-PABC-OH
ADC Linker Cancer

Azide-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140148

Azido-PEG3-Val-Cit-PAB-OH
ADC Linker Cancer

Azido-PEG3-Val-Cit-PAB-OH is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133576

Cyclooctyne-O-amido-PEG4-PFP ester	ADC Linker	Cancer
Cyclooctyne-O-amido-PEG4-PFP ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133575

Cyclooctyne-O-amido-PEG3-PFP ester	ADC Linker	Cancer
Cyclooctyne-O-amido-PEG3-PFP ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141150

Azido-PEG5-Ala-Ala-Asn-PAB
ADC Linker Cancer

Azido-PEG5-Ala-Ala-Asn-PAB is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133545

Mal-Ph-CONH-PEG4-NHS ester
ADC Linker Cancer

Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136100

TCO-PEG1-Val-Cit-PABC-PNP
ADC Linker Cancer

TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136108

Fmoc-Gly3-Val-Cit-PAB-PNP
ADC Linker Cancer

Fmoc-Gly3-Val-Cit-PAB-PNP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141149

Fmoc-PEG4-Ala-Ala-Asn-PAB
ADC Linker Cancer

Fmoc-PEG4-Ala-Ala-Asn-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136157

Py-ds-dmBut-amido-PEG4-NHS ester
ADC Linker Cancer

Py-ds-dmBut-amido-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133426

Ald-Ph-amido-PEG4-propargyl Ald-benzyl-amide-PEG4-propargyl	ADC Linker	Cancer
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140113

Acid-PEG3-SS-PEG3-acid
ADC Linker Cancer

Acid-PEG3-SS-PEG3-acid is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130966

TCO-PEG1-Val-Cit-PABC-OH
ADC Linker Cancer

TCO-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136155

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester	ADC Linker	Cancer
Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136098

DBCO-PEG4-acetic-Val-Cit-PAB
ADC Linker Cancer

DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136054

N3-PEG5-aldehyde
ADC Linker Cancer

N3-PEG5-aldehyde is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140143

Mal-PEG4-Val-Cit-PAB-OH
ADC Linker Cancer

Mal-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-20336

Mc-Val-Cit-PABC-PNP Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate	ADC Linker	Cancer
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-141154

Amino-PEG4-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-131082

(R)-8-Azido-2-(Fmoc-amino)octanoic acid	ADC Linker	Cancer
(R)-8-Azido-2-(Fmoc-amino)octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-131087

Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc	ADC Linker	Cancer
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140112

Acid-PEG2-SS-PEG2-acid
ADC Linker Cancer

Acid-PEG2-SS-PEG2-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130944

Mal-PEG1-Val-Cit-PABC-OH
ADC Linker Cancer

Mal-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133436

Boc-aminooxy-amide-PEG4-propargyl	ADC Linker	Cancer
Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133573

Cyclooctyne-O-amido-PEG2-PFP ester	ADC Linker	Cancer
Cyclooctyne-O-amido-PEG2-PFP ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-132973

MC-Val-Cit-PAB-NH-C2-NH-Boc
ADC Linker Cancer

MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133579

Ald-Ph-amido-PEG3-NHS ester
ADC Linker Cancer

Ald-Ph-amido-PEG3-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-126669

Mal-PEG4-VA
ADC Linker Cancer

Mal-PEG4-VA is a cleavable ADC linker containing a Maleimide group. Mal-PEG4-VA is used for making antibody-drug conjugate.
HY-136103

DBCO-PEG4-Propionic-Val-Cit-PAB
ADC Linker Cancer

DBCO-PEG4-Propionic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133409

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid	ADC Linker	Cancer
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136105

Azido-PEG1-Val-Cit-PABC-PNP
ADC Linker Cancer

Azido-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130923

BCN-PEG1-Val-Cit-PABC-OH
ADC Linker Cancer

BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141155

endo-BCN-PEG4-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-129655

Sulfo-SMPB sodium	ADC Linker	Cancer
Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules.

HY-141151

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
ADC Linker Cancer

Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140147

Mal-amido-PEG2-Val-Cit-PAB-PNP
ADC Linker Cancer

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-141146

Mal-amido-PEG8-val-gly-PAB-OH
ADC Linker Cancer

Mal-amido-PEG8-val-gly-PAB-OH is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133572

Ald-Ph-amido-PEG11-NH-Boc
ADC Linker Cancer

Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140146

Mal-amido-PEG2-Val-Cit-PAB-OH
ADC Linker Cancer

Mal-amido-PEG2-Val-Cit-PAB-OH is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-115524

DBCO-NHS ester 2	ADC Linker	Cancer
DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.

HY-136317

MC-betaglucuronide-MMAE-1	Drug-Linker Conjugates for ADC	Cancer
MC-betaglucuronide-MMAE-1 is a drug-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

HY-136321

MC-betaglucuronide-MMAE-2	Drug-Linker Conjugates for ADC	Cancer
MC-betaglucuronide-MMAE-2 is a drug-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

HY-132159

MC-AAA-NHCH2OCH2COOH
ADC Linker Cancer

MC-AAA-NHCH2OCH2COOH (compound 20) is a cleavable ADC linker that is used for making antibody-drug conjugate (ADC).
HY-130315

Br-PEG4-C2-Boc
ADC Linker PROTAC Linkers Cancer

Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-W096148

Biotin-C4-amide-C5-NH2
ADC Linker Cancer

Biotin-C4-amide-C5-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-139956

Mal-amido-PEG9-Val-Ala-PAB-SG3200
ADC Linker Cancer

Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).

HY-126494

DM4-SMCC	Drug-Linker Conjugates for ADC	Cancer
DM4-SMCC is a drug-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.

HY-140109

Propargyl-PEG1-SS-PEG1-acid
ADC Linker Cancer

Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136076

TCO-PEG3-CH2-aldehyde
ADC Linker Cancer

TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136131

NH2-PEG4-hydrazone-DBCO
ADC Linker Cancer

NH2-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136133

NHS-PEG2-SS-PEG2-NHS
ADC Linker Cancer

NHS-PEG2-SS-PEG2-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140121

m-PEG6-SS-PEG6-methyl
ADC Linker Cancer

m-PEG6-SS-PEG6-methyl is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136058

N3-PEG4-amido-Lys(Fmoc)-acid
ADC Linker Cancer

N3-PEG4-amido-Lys(Fmoc)-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-135970

Alkyne-PEG4-SS-PEG4-alkyne
ADC Linker Cancer

Alkyne-PEG4-SS-PEG4-alkyne is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-112157

PF-06751979	Beta-secretase	Neurological Disease
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 7.3 nM in BACE1 binding assay.

HY-130968

Amino-PEG4-bis-PEG3-propargyl
ADC Linker Cancer

Amino-PEG4-bis-PEG3-propargyl is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-E70023

Sphingolipid ceramide N-deacylase SCDase	Endogenous Metabolite	Metabolic Disease
Sphingolipid ceramide N-deacylase (SCDase) cleaves the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids. Sphingolipid ceramide N-deacylase catalyzes glycosphingolipids to lysoglycosphingolipids.

HY-136088

Acid-PEG1-bis-PEG3-BCN
ADC Linker Cancer

Acid-PEG1-bis-PEG3-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133581

Mal-PEG3-C1-NHS ester
ADC Linker Cancer

Mal-PEG3-C1-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130973

Mal-PEG4-bis-PEG4-propargyl
ADC Linker Cancer

Mal-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-111428

Phleomycin D1 PLM D1	Antibiotic	Infection
Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA.

HY-P99593

Sofituzumab vedotin DMUC5754A	Antibody-Drug Conjugates (ADCs)	Cancer
Sofituzumab vedotin (DMUC5754A) is a MMAE-containing anti-MUC16 antibody-drug conjugate (ADC) with a protease-cleavable linker. Sofituzumab vedotin can be used for the research of cancer.

HY-130971

Mal-PEG4-bis-PEG3-DBCO
ADC Linker Cancer

Mal-PEG4-bis-PEG3-DBCO is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130943

Methyltetrazine-PEG4-SS-PEG4-methyltetrazine	ADC Linker	Cancer
Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140111

Propargyl-PEG1-SS-PEG1-propargyl
ADC Linker Cancer

Propargyl-PEG1-SS-PEG1-propargyl is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130970

Amino-PEG4-bis-PEG3-methyltetrazine	ADC Linker	Cancer
Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130953

Mal-PEG4-bis-PEG3-methyltetrazine
ADC Linker Cancer

Mal-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136089

Aminooxy-PEG2-bis-PEG3-BCN
ADC Linker Cancer

Aminooxy-PEG2-bis-PEG3-BCN is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-144739

BACE1-IN-8
Beta-secretase Neurological Disease

BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 3.9 µM.
HY-140110

Propargyl-PEG1-SS-PEG1-PFP ester
ADC Linker Cancer

Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dye	Others
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm).

HY-140634

Ald-CH2-PEG5-azide
ADC Linker Cancer

Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-140133

PC-Biotin-PEG4-PEG3-azide
ADC Linker Cancer

PC-Biotin-PEG4-PEG3-azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W034918

Docosanedioic acid	ADC Linker PROTAC Linkers	Cancer
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-136060

Mal-PEG2-bis-PEG3-BCN
ADC Linker Cancer

Mal-PEG2-bis-PEG3-BCN is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136318

β-D-tetraacetylgalactopyranoside-PEG1-N3	ADC Linker	Cancer
β-D-tetraacetylgalactopyranoside-PEG1-N3 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-144741

BACE1-IN-9
Beta-secretase Neurological Disease

BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC₅₀ of 1.2 µM.
HY-W040135

Fmoc-NH-PEG8-CH2CH2COOH
ADC Linker PROTAC Linkers Cancer

Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-133574

Mal-amido-PEG3-C1-PFP ester
ADC Linker Cancer

Mal-amido-PEG3-C1-PFP ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130929

β-Estradiol-6-CMO-PEG3-biotin
ADC Linker Cancer

β-Estradiol-6-CMO-PEG3-biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136316

MC-VC-PAB-MMAD	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
MC-VC-PAB-MMAD is a drug-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker MC-VC-PAB.

HY-W040246

Fmoc-NH-PEG6-CH2CH2COOH
ADC Linker PROTAC Linkers Cancer

Fmoc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130967

Ald-Ph-PEG4-bis-PEG4-propargyl
ADC Linker Cancer

Ald-Ph-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130974

Ald-Ph-PEG4-bis-PEG3-methyltetrazine	ADC Linker	Cancer
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141091

Biotin-PEG4-Dde-TAMRA-PEG3-Azide
ADC Linker Cancer

Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-130931

Propargyl-NH-PEG3-C2-NHS ester
ADC Linker Cancer

Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136315

OSu-Glu-VC-PAB-MMAD	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
OSu-Glu-VC-PAB-MMAD is a drug-linker conjugate for ADC with potent antitumor activity by using MMAD (a potent tubulin inhibitor), linked via the cleavable ADC linker OSu-Glu-VC-PAB.

HY-133539

Propargyl-C8-amido-PEG2-NHS ester	ADC Linker	Cancer
Propargyl-C8-amido-PEG2-NHS ester is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133582

Mal-amido-PEG3-C1-NHS ester
ADC Linker Cancer

Mal-amido-PEG3-C1-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136290

Mc-Dexamethasone	Drug-Linker Conjugates for ADC	Cancer
Mc-Dexamethasone is a drug-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasone (HY-14648) conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist.

HY-133492

DBCO-PEG4-MMAF	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4.

HY-111496

Sulfo-NHS-SS-Biotin sodium	Fluorescent Dye	Others
Sulfo-NHS-SS-biotin is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin can be used for the labeling and purifying of cell-surface protein.

HY-130546

Hydroxy-PEG3-SS-PEG3-alcohol
ADC Linker Cancer

Hydroxy-PEG3-SS-PEG3-alcohol is also a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W125504

AEEA-AEEA	ADC Linker PROTAC Linkers	Cancer
AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130818

N-(5-Hydroxypentyl)maleimide	ADC Linker	Cancer
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) ).

HY-117095

4-Methylumbelliferyl oleate	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm).

HY-128954

Sulfo-PDBA-DM4	Drug-Linker Conjugates for ADC	Cancer Inflammation/Immunology
Sulfo-PDBA-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody drug conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.

HY-44149

m-C-tri(CH2-PEG1-NHS ester)
ADC Linker Cancer

m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N1988

Cucurbitacin IIa Hemslecin A	Survivin Apoptosis	Cancer
Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells.

HY-121805

DBCO-C6-acid	ADC Linker	Cancer
DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues.

HY-136090

Amino-PEG4-bis-PEG3-N3
ADC Linker Cancer

Amino-PEG4-bis-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136320

MC-VC-PABC-SP 141	Drug-Linker Conjugates for ADC MDM-2/p53	Cancer
MC-VC-PABC-SP 141 is a drug-linker conjugate for ADC with potent antitumor activity by using SP 141 (a potent MDM2 inhibitor), linked via the cleavable ADC linker MC-VC-PABC.

HY-76043

H-Hyp-OMe hydrochloride	ADC Linker PROTAC Linkers	Cancer
H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]<

HY-W010975

Fmoc-Lys-OH hydrochloride	ADC Linker PROTAC Linkers	Cancer
Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-108379

Boc-C2-Urea-bis(Boc)-C4-Urea-4-phenylacetic acid	ADC Linker	Cancer
Boc-C2-Urea-bis(Boc)-C4-Urea-4-phenylacetic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140101

Azido-C2-SS-PEG2-C2-acid
ADC Linker Cancer

Azido-C2-SS-PEG2-C2-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W016429

H-cis-Hyp-OMe hydrochloride	ADC Linker PROTAC Linkers	Cancer
H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR

HY-41541

Tetraethylene glycol monotosylate Tos-PEG4	ADC Linker PROTAC Linkers	Cancer
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

HY-131085

Desmethyl Vc-seco-DUBA	Drug-Linker Conjugates for ADC	Cancer
Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-130957

Amino-PEG6-amido-bis-PEG5-N3
ADC Linker Cancer

Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-P3150

Recombinant Proteinase K	Ser/Thr Protease	Others
Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations.

HY-130969

Ald-Ph-PEG4-bis-PEG3-N3
ADC Linker Cancer

Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126671

Mal-Phe-C4-Val-Cit-PAB	ADC Linker	Cancer
Mal-Phe-C4-Val-Cit-PAB is a cleavable ADC linker containing a Maleimide group. Mal-Phe-C4-Val-Cit-PAB is used for making antibody-drug conjugate.

HY-P1241

BAM(8-22)	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

HY-133546

Ald-Ph-amido-PEG11-C2-NH2
ADC Linker Cancer

Ald-Ph-amido-PEG11-C2-NH2 is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W017755

(R)-Azetidine-2-carboxylic acid	ADC Linker PROTAC Linkers	Cancer
(R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be

HY-65039

Boc-Hyp-OMe	ADC Linker PROTAC Linkers	Cancer
Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140242

NH2-PEG4-Lys(Boc)-NH-(m-PEG24)
ADC Linker Cancer

NH2-PEG4-Lys(Boc)-NH-(m-PEG24) is a cleavable 28 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-136084

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO)
ADC Linker Cancer

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136130

N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol	ADC Linker	Cancer
N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-I0781

Boc-Hyp-OH	ADC Linker PROTAC Linkers	Cancer
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2]

HY-W018154

H-Glu-OtBu	ADC Linker PROTAC Linkers	Cancer
H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2

HY-137845

4-Methylumbelliferyl β-D-galactopyranoside	Fluorescent Dye	Others
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer.

HY-126886

Mal-PEG1-NHS ester	ADC Linker PROTAC Linkers	Cancer
Mal-PEG1-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-NHS ester is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-42972

DBCO-acid	ADC Linker	Cancer
DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690).

HY-40144

Azetidin-3-ol hydrochloride	ADC Linker PROTAC Linkers	Cancer
Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.

HY-126681

SC-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
SC-VC-PAB-MMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker SC-VC-PAB.

HY-126668

Mal-PEG4-VC-PAB-DMEA	ADC Linker	Cancer
Mal-PEG4-VC-PAB-DMEA is a cleavable ADC linker containing a Maleimide group. Mal-PEG4-VC-PAB-DMEA is used in the synthesis of antibody-drug conjugates (ADCs).

HY-129372

PDdB-Pfp
ADC Linker Cancer

PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1).

HY-P1241A

BAM(8-22) TFA	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
BAM(8-22) TFA, a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

HY-130166

Amino-PEG9-acid	ADC Linker PROTAC Linkers	Cancer
Amino-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG9-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126672

Mal-PEG4-Val-Cit-PAB	ADC Linker	Cancer
Mal-PEG4-Val-Cit-PAB is a cleavable ADC linker containing a Maleimide group. Mal-PEG4-Val-Cit-PAB is used in the synthesis of antibody-drug conjugates (ADCs).

HY-79125

Fmoc-Hyp(Bom)-OH	ADC Linker PROTAC Linkers	Cancer
Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

HY-15575

VcMMAE MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

HY-126958

Biotin-PEG2-acid	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126674

Mal-Phe-C4-Val-Cit-PAB-DMEA	ADC Linker	Cancer
Mal-Phe-C4-Val-Cit-PAB-DMEA is a cleavable ADC linker containing a Maleimide group. Mal-Phe-C4-Val-Cit-PAB-DMEA is used for making antibody-drug conjugate.

HY-130528

m-PEG7-Ms	ADC Linker PROTAC Linkers	Cancer
m-PEG7-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130408

m-PEG6-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W018174

m-PEG3-Amine	ADC Linker PROTAC Linkers	Cancer
m-PEG3-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-148131

MC-Val-Cit-PABA-amide-PEG4-COOH	ADC Linker	Cancer
MC-Val-Cit-PABA-amide-PEG4-COOH is a cleavable ADC linker used in the synthesis of OMTX705. OMTX705 is a novel FAP-targeting antibody-drug conjugates (ADCs), and shows antitumor activity.

HY-130346

DBCO-PEG4-DBCO	ADC Linker PROTAC Linkers	Cancer
DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126561

Green CMFDA CMFDA	Fluorescent Dye	Others
Green CMFDA (CMFDA) is a cell-permeable fluorescent probe that can be used a cell tracer. Green CMFDA can be cleaved by non-specific esterases common to living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope.

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-130475

Azido-PEG9-acid	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126673

Mal-C2-Gly3-EDA
ADC Linker Cancer

Mal-C2-Gly3-EDA is a cleavable ADC linker containing a Maleimide group. Mal-C2-Gly3-EDA is used for making antibody-drug conjugate.

HY-136297

DGN549-C	Drug-Linker Conjugates for ADC	Cancer
DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-145383

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide	Fluorescent Dye	Others
Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide. Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is an enrichment handle of cell surface glycoproteins for protein labeling.

HY-131833A

Fmoc-Gly-Gly-D-Phe-OH	ADC Linker	Cancer
Fmoc-Gly-Gly-D-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OH is the D-isomer of Fmoc-Gly-Gly-Phe-OH (HY-131833).

HY-140310

TCO-PEG4-DBCO	ADC Linker PROTAC Linkers	Cancer
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133583

Propargyl-O-C1-amido-PEG3-C2-NHS ester	ADC Linker	Cancer
Propargyl-O-C1-amido-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-141379

N-Bromoacetyl-β-alanine	PROTAC Linkers ADC Linker	Cancer
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N6800A

Netropsin dihydrochloride	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus.

HY-126960

Mal-PEG1-acid	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Mal-PEG1-acid is is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-125541

DBCO-NHCO-PEG4-acid	ADC Linker PROTAC Linkers	Cancer
DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130410

Bis-PEG6-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-116427

Propargyl-PEG4-thiol	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130328

NH-bis-PEG2	ADC Linker PROTAC Linkers	Cancer
NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130372

Propargyl-PEG9-bromide	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG9-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-33615

Methyl azetidine-3-carboxylate hydrochloride	ADC Linker PROTAC Linkers	Cancer
Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

HY-136129

N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol	ADC Linker	Cancer
N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Microtubule/Tubulin Beta-secretase Apoptosis	Cancer
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

HY-130591

Propargyl-PEG4-Br	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126976

Propargyl-PEG5-amine	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-130377

Propargyl-PEG8-bromide	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-139292

Fmoc-NH-PEG6-alcohol	Amino Acid Derivatives	Cancer
Fmoc-NH-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-alcohol is extracted from patent WO2016030791, example comp 91.

HY-44234A

Fmoc-Gly-Gly-D-Phe-OtBu	ADC Linker	Cancer
Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234).

HY-148326

Glu(OtBu)-Val-Cit-PAB-OH	ADC Linker	Others
Glu(OtBu)-Val-Cit-PAB-OH (compound L5-1c) is an non-cleavable ADC linker. Glu(OtBu)-Val-Cit-PAB-OH has been used to synthesis protein-tubulysin conjugates.

HY-130812

Gemcitabine-O-Si(di-iso)-O-Mc	Drug-Linker Conjugates for ADC	Cancer
Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker.

HY-Y0530

Azetidine-3-carboxylic acid	ADC Linker PROTAC Linkers	Cancer
Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2

HY-130165

Tr-PEG8-OH	ADC Linker PROTAC Linkers	Cancer Inflammation/Immunology
Tr-PEG8-OH is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-111554

AcLys-PABC-VC-Aur0101	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
AcLys-PABC-VC-Aur0101 is a drug-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the cleavable linker AcLys-PABC-VC.

HY-120845

Tr-PEG5-OH	ADC Linker PROTAC Linkers	Cancer Inflammation/Immunology
Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-108751

Aripiprazole Lauroxil	Others	Neurological Disease
Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.

HY-117009

Bis-PEG9-NHS ester	ADC Linker PROTAC Linkers	Cancer
Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-108966

Kushenol C	Beta-secretase	Inflammation/Immunology
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP cleaving* enzyme 1) with an IC₅₀** of 5.45 µM.

HY-139859

APN-PEG36-tetrazine	ADC Linker	Cancer
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-115545

DBCO-NHS ester 3	ADC Linker	Cancer
DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC).

HY-W019213

cis-4-Hydroxy-L-proline hydrochloride	ADC Linker PROTAC Linkers	Cancer
cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-112786

MC-Val-Cit-PAB-MMAF Vc-MMAF	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB. MC-Val-Cit-PAB-MMAF shows antitumor activity.

HY-W051634

Propargyl-PEG2-amine	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-W017882

Boc-trans-D-Hyp-OMe	ADC Linker PROTAC Linkers	Cancer
Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-118764

Propargyl-PEG2-acid	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W003511

tans-4-Hydroxy-D-proline hydrochloride	ADC Linker PROTAC Linkers	Cancer
tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR

HY-126885

DBCO-PEG5-NHS ester	ADC Linker PROTAC Linkers	Cancer
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140454

Azido-PEG8-acid	ADC Linker PROTAC Linkers	Cancer
Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-131057

Mc-VC-PAB-SN38	Drug-Linker Conjugates for ADC	Cancer
Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-W045598

Boc-C16-COOH	ADC Linker PROTAC Linkers	Cancer
Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

HY-141156

Mal-PEG8-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG8-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Mal-PEG8-Val-Cit-PAB-MMAE contains a cleavable ADC linker and a potent tubulin inhibitor MMAE (HY-15162).

HY-148245

OH-Glu-Val-Cit-PAB-MMAE	ADC Linker	Cancer
OH-Glu-Val-Cit-PAB-MMAE consists a cleavable ADC linker (OH-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-106409

Tefinostat CHR-2845	HDAC Apoptosis	Cancer
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias.

HY-117104

Hydroxy-PEG4-acid	ADC Linker PROTAC Linkers	Cancer
Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W011277

Fmoc-azetidine-3-carboxylic acid	ADC Linker PROTAC Linkers	Cancer
Fmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-U00287

BACE-IN-1	Beta-secretase	Neurological Disease
BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

HY-77475

1-Cbz-3-Hydroxyazetidine	ADC Linker PROTAC Linkers	Cancer
1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130989

SuO-Glu-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
SuO-Glu-Val-Cit-PAB-MMAE consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-141385

N-Succinimidyl 3-(Bromoacetamido)propionate 3-(2-Bromoacetamido)propanoic acid NHS ester	PROTAC Linkers ADC Linker	Cancer
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-111456

DBCO-NHCO-PEG4-NHS ester	ADC Linker PROTAC Linkers	Cancer
DBCO-NHCO-PEG4-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-76105

D-Proline, 4-hydroxy-, methyl ester hydrochloride	ADC Linker PROTAC Linkers	Cancer
D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2

HY-W052600

Ethyl azetidine-3-carboxylate hydrochloride	ADC Linker PROTAC Linkers	Cancer
Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2]

HY-N11322

Bitis Arietans Venom Puff Adder Venom	Others	Cardiovascular Disease
Bitis Arietans Venom (Puff Adder Venom) is a snake venom that can be obtained from Bitis Arietans. Bitis Arietans Venom inhibits platelet aggregation. The fibrinogenase can be purified from the Bitis Arietans Venom, and cleaves the Aα and Bβ chain of fibrinogen.

HY-131498

MOCAc-PLGL(Dpa)AR	Fluorescent Dye	Others
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues.

HY-W034599

Boc-C14-COOH	ADC Linker PROTAC Linkers	Cancer
Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W019799

Amino-PEG8-Boc	ADC Linker PROTAC Linkers	Cancer
Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG8-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2988

Neuraminidase Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection.

HY-141382

Bromoacetamido-PEG4-acid	PROTAC Linkers ADC Linker	Cancer
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-145929

MC-Val-Cit-PAB-Exatecan MC-Val-Cit-PAB-DX8951	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a drug-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker.

HY-P99734

Mipasetamab uzoptirine ADCT-601	TAM Receptor	Cancer
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers.

HY-P99774

Pivekimab sunirine IMGN 632; PVEK	Antibody-Drug Conjugates (ADCs)	Cancer
Pivekimab sunirine (IMGN 632) is an antibody-drug conjugate (ADC) targeting CD123. Pivekimab sunirine comprises a high-affinity CD123 antibody, cleavable linker, and an indolinobenzodiazepine pseudodimer (IGN) payload. Pivekimab sunirine can be used for research of hematological malignancies.

HY-W045822

Fmoc-Lys(Pal-Glu-OtBu)-OH	ADC Linker PROTAC Linkers	Cancer
Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W046348

22-(tert-Butoxy)-22-oxodocosanoic acid	ADC Linker PROTAC Linkers	Cancer
22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

HY-133066

m-PEG6-NHS ester	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

HY-128945

CL2A	ADC Linker	Cancer Inflammation/Immunology
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

HY-140501

m-PEG11-acid	ADC Linker PROTAC Linkers	Cancer
m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126942

Amino-PEG6-alcohol	ADC Linker PROTAC Linkers	Cancer
Amino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

HY-130324

Azido-PEG7-amine	ADC Linker PROTAC Linkers	Cancer
Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-145663

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM	Drug-Linker Conjugates for ADC	Cancer
HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a drug-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety.

HY-130298

Amino-PEG11-OH	ADC Linker PROTAC Linkers	Cancer
Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.

HY-W034597

20-(tert-Butoxy)-20-oxoicosanoic acid	ADC Linker PROTAC Linkers	Cancer
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

HY-140500

m-PEG10-acid	ADC Linker PROTAC Linkers	Cancer
m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P99050

Sutimlimab	Complement System	Inflammation/Immunology Cardiovascular Disease
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase.

HY-130169

Azido-PEG9-amine	ADC Linker PROTAC Linkers	Cancer
Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-145674

HDP 30.1699	Others	Cancer
HDP 30.1699, the derivative of α-Amanitin，shows considerable cross-links. The cysteine residues of the anti-HER2 THIOMAB antibody are used for conjugation of the cysteine reactive linker–Amanitin compound, HDP 30.1699, with a cleavable linker by maleimide chemistry.

HY-40142

1-N-Boc-3-hydroxyazetidine	ADC Linker PROTAC Linkers	Cancer
1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

HY-120761

Amino-PEG10-OH	ADC Linker PROTAC Linkers	Cancer
Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-145762

YM281	Apoptosis Histone Methyltransferase	Cancer
YM281 is a potent EZH2 inhibitor. YM281 induces cell apoptosis and cell cycle arrest at the G0/G1 phase. YM281 shows antitumor effects in vivo. YM281 has the potential for the research of lymphoma.

HY-P9985

Disitamab vedotin RC48	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.

HY-76104

cis-4-Hydroxy-D-proline hydrochloride	ADC Linker PROTAC Linkers	Cancer
cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-126688

Mal-C2-Gly3-EDA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for ADC, consists a cleavable ADC linker Mal-C2-Gly3-EDA and a potent ADC cytotoxin PNU-159682.

HY-W002887

N-Boc-cis-4-Hydroxy-D-proline	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth

HY-126884

DBCO-NHCO-PEG4-NH-Boc	ADC Linker PROTAC Linkers	Cancer
DBCO-NHCO-PEG4-NH-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W042654

BnO-PEG6-OH	ADC Linker PROTAC Linkers	Cancer Inflammation/Immunology
BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-126676

DBCO-(PEG2-Val-Cit-PAB)2	ADC Linker PROTAC Linkers	Cancer
DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs). DBCO-(PEG2-Val-Cit-PAB)2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-128774

AM-6494	Beta-secretase	Neurological Disease
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM).

HY-W320032

5-Bromo-1H-indol-3-yl octanoate	Fluorescent Dye	Others
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.

HY-130150

m-PEG5-succinimidyl carbonate	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

HY-P99547

Trastuzumab duocarmazine (vic)-Trastuzumab duocarmazine	Antibody-Drug Conjugates (ADCs)	Cancer
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas.

HY-131056

Gly3-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-140215

Azido-PEG6-amine	PROTAC Linkers ADC Linker	Cancer
Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-126918

THP-PEG6-OH	PROTAC Linkers ADC Linker	Cancer
THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140226

m-PEG10-amine	ADC Linker PROTAC Linkers	Cancer
m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-151944

Antibacterial agent 128	Bacterial Antibiotic	Infection
Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against *P. aeruginosa* (MIC values of 0.25-64 μg/mL) and *B. pseudomallei* (MIC values of 1-32 μg/mL).

HY-126951

Aminooxy-PEG2-alcohol	ADC Linker PROTAC Linkers	Cancer
Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-147064

DL-4-Hydroxy-2-ketoglutarate lithium	Others	Others
DL-4-Hydroxy-2-ketoglutarate lithium is the substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate lithium can be cleaved by HOGA to produce pyruvate and glyoxylate.

HY-140004

Azide-PEG3-Tos	PROTAC Linkers ADC Linker	Cancer
Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-113931

Aminooxy-PEG2-azide	PROTAC Linkers ADC Linker	Cancer
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-136313

MC-VC-PAB-Tubulysin M	Drug-Linker Conjugates for ADC	Cancer
MC-vc-PAB-Tubulysin M consists a cleavable ADC linker (MC-vc-PAB) and a cytotoxic tubulin inhibitor Tubulysin M (HY-N7053). Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

HY-130537

Azido-PEG6-alcohol	PROTAC Linkers ADC Linker	Cancer
Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130211

Azido-PEG5-alcohol	ADC Linker PROTAC Linkers	Cancer
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-141220

m-PEG12-OH	PROTAC Linkers ADC Linker	Cancer
m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130946

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3
ADC Linker Cancer

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140227

m-PEG12-amine	PROTAC Linkers ADC Linker	Cancer
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W190943

Azido-PEG4-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH.

HY-113354

Anserine	Endogenous Metabolite	Neurological Disease
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.

HY-124123

Aminooxy-PEG4-alcohol	ADC Linker PROTAC Linkers	Cancer
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-147021

MC-Val-D-Cit-PAB-PNP	ADC Linker	Cancer
MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). MC-Val-D-Cit-PAB-PNP contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to antitumor compounds.

HY-W008005

Amino-PEG4-alcohol	PROTAC Linkers ADC Linker	Cancer
Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-114995

Tr-PEG2-OH	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-145657

Benzoquinoquinoxaline BQQ	Others	Others
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure.

HY-W004868

1-Cbz-azetidine-3-carboxylic acid	ADC Linker PROTAC Linkers	Cancer
1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]

HY-P99595

Sirtratumab vedotin AGS15E; ASG-15ME; 1vcMMAE	Antibody-Drug Conjugates (ADCs)	Cancer
Sirtratumab vedotin (ASG15-ME) is an ADC composed of a SLITRK6-specific human gamma 2 antibody (Igγ2) conjugated to a small molecule microtubule disrupting agent, monomethyl auristatin E (MMAE) via a protease-cleavable linker.

HY-126690

DBCO-(PEG2-VC-PAB-MMAE)2	Drug-Linker Conjugates for ADC	Cancer
DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

HY-115384

Amino-PEG5-C2-acid	ADC Linker PROTAC Linkers	Cancer
Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-119689

Umibecestat CNP520	Beta-secretase	Neurological Disease
Umibecestat (CNP520) is a *beta-site amyloid precursor protein cleaving* enzyme-1 (BACE-1) inhibitor with IC₅₀**s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.

HY-130182

Propargyl-PEG8-NH2	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG8-NH2 (compound 3b) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-120775

Boc-NH-PEG1-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.

HY-W040165

Amino-PEG3-C2-acid	ADC Linker PROTAC Linkers	Cancer
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140151

BCN-PEG3-Val-Cit	PROTAC Linkers ADC Linker	Cancer
BCN-PEG3-Val-Cit is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG3-Val-Cit is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W006629

tans-4-Hydroxy-D-proline methyl ester hydrochloride	ADC Linker PROTAC Linkers	Cancer
tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2834

Penicillin amidase Penicillin acylase	Biochemical Assay Reagents	Infection
Penicillin amidase (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics.

HY-40141

1-Boc-azetidine-3-carboxylic acid	ADC Linker PROTAC Linkers	Cancer
1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2]

HY-148057

TCO-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162).

HY-W002886

N-Boc-cis-4-hydroxy-L-proline	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2

HY-112560

Bis-PEG2-PFP ester	PROTAC Linkers ADC Linker	Cancer
Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130485

Bromo-PEG2-C2-azide	ADC Linker PROTAC Linkers	Cancer
Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-D1643

5,5'-Dinitro BAPTA AM	Biochemical Assay Reagents	Others
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca²⁺. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand.

HY-W040168

Amino-PEG2-C2-acid	ADC Linker PROTAC Linkers	Cancer
Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-140081

Boc-gly-PEG3-endo-BCN	PROTAC Linkers ADC Linker	Cancer
Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-40151

Methyl 1-Boc-azetidine-3-carboxylate	ADC Linker PROTAC Linkers	Cancer
Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1

HY-40152

1-Boc-azetidine-3-yl-methanol	ADC Linker PROTAC Linkers	Cancer
1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]

HY-N8481

3,6-Dihydroxyflavone 3,6-DHF	Apoptosis	Cancer
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation.

HY-120537

m-PEG5-CH2COOH	ADC Linker PROTAC Linkers	Cancer
m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W019226

Methyl 1-Cbz-azetidine-3-carboxylate	ADC Linker PROTAC Linkers	Cancer
Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1

HY-15827

NSC 405020	MMP	Cancer Cardiovascular Disease
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis.

HY-P2963

Nuclease P1	Endogenous Metabolite	Others
Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries.

HY-Y0755

N-Boc-4-hydroxy-L-proline methyl ester	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[2

HY-15883

GNE-900	Checkpoint Kinase (Chk) Apoptosis	Cancer
GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC₅₀s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity.

HY-134723

DBCO-PEG4-GGFG-Exatecan DBCO-PEG4-GGFG-DX8951	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-GGFG-Exatecan (DBCO-PEG4-GGFG-DX8951) is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG.

HY-114233

MC-GGFG-Exatecan MC-GGFG-DX8951	Drug-Linker Conjugates for ADC	Cancer
MC-GGFG-Exatecan (MC-GGFG-DX8951) is a drug-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC).

HY-136291

Sulfo-SPDB-DGN462	Drug-Linker Conjugates for ADC	Cancer
Sulfo-SPDB-DGN462 is a drug-linker conjugate for ADC. Sulfo-SPDB-DGN462 consists a toxin DGN462 (HY-101150) conjugated to the cleavable Sulfo-SPDB linker. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).

HY-126949

Aminooxy-PEG3-azide	ADC Linker PROTAC Linkers	Cancer
Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-113149

Argininosuccinic acid	Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology
Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain.

HY-42640

Boc-NH-PEG4-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-111555

AmPEG6C2-Aur0131	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
AmPEG6C2-Aur0131 is a drug-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0131 (an auristatin microtubule inhibitor), linked via the non-cleavable linker AmPEG6C2.

HY-130144

Ald-CH2-PEG3-azide	ADC Linker PROTAC Linkers	Cancer
Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ald-CH2-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

HY-141218

m-PEG10-alcohol Decaethylene glycol monomethyl ether	ADC Linker PROTAC Linkers	Cancer
m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130653

Azido-PEG4-C2-acid	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133062

Fmoc-NH-PEG5-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG5-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130572

Azido-PEG5-acid	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130364

Fmoc-NH-PEG6-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W002680

N-Boc-cis-4-hydroxy-D-proline methyl ester	ADC Linker PROTAC Linkers	Cancer
N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1

HY-W019798

NH2-PEG9-acid	ADC Linker PROTAC Linkers	Cancer
NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG9-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-133063

Fmoc-NH-PEG8-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W055861

Fmoc-NH-PEG1-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG1-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P3017

Endo-1,4-β-xylanase Xylanase; CtXyn11A; EC 3.2.1.8	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
Endo-1,4-β-xylanase (Xylanase) is an arabinoxylan (AX) degrading enzyme and a glycoside hydrolase, is often used in biochemical studies. Endo-1,4-β-xylanase cleaves the β-xylosidic bond between two d-xylopyranosyl residues linked in β-(1,4).

HY-130175

Fmoc-NH-PEG4-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-77593

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline	ADC Linker PROTAC Linkers	Cancer
N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-109052

Atabecestat JNJ-54861911	Beta-secretase	Neurological Disease
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active *β-site amyloid precursor protein cleaving* enzyme 1 (BACE1)** inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment.

HY-131088

N3-PEG8-Phe-Lys-PABC-Gefitinib	Drug-Linker Conjugates for ADC	Cancer
N3-PEG8-Phe-Lys-PABC-Gefitinib is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-tumor agent, Gefitinib (orally active EGFR tyrosine kinase inhibitor), linked via the cleavable linker N3-PEG8-Phe-Lys-PABC.

HY-130486

NH2-PEG6-Boc	PROTAC Linkers ADC Linker	Cancer
NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130442

Mal-PEG2-acid	ADC Linker PROTAC Linkers	Cancer
Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.

HY-P99813

Patritumab deruxtecan HER3-DXd; U3-1287	Antibody-Drug Conjugates (ADCs)	Cancer
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.

HY-129637

NH2-PEG5-OH	PROTAC Linkers ADC Linker	Cancer
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-113354S

Anserine-d4	Endogenous Metabolite	Neurological Disease
Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-126493

DM4-SPDP	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

HY-136170

MC-SN38	Drug-Linker Conjugates for ADC	Cancer
MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks.

HY-146433

Anticancer agent 55	Apoptosis	Cancer
Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer.

HY-130524

Amino-PEG4-CH2COOH	PROTAC Linkers ADC Linker	Cancer
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-147906

Anticancer agent 71	Apoptosis PARP	Cancer
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.

HY-130185

m-PEG7-CH2CH2CHO	ADC Linker PROTAC Linkers	Cancer
m-PEG7-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P2810

Rennin	Endogenous Metabolite Ser/Thr Protease	Metabolic Disease
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production.

HY-130990

DBCO-PEG4-Val-Cit-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-W067509

m-PEG3-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
m-PEG3-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-130244

BACE1-IN-5	Beta-secretase	Neurological Disease
BACE1-IN-5 (Compound 15) is a *β-site amyloid precursor protein cleaving* enzyme 1 (BACE1) inhibitor with an IC₅₀ of 9.1 nM, and also inhibits cellular amyloid-β (Aβ) with an IC₅₀** of 0.82 nM. BACE1-IN-5 has a medicinal chemistry that improves hERG inhibition and P-gp efflux.

HY-101157

Propargyl-PEG5-acid	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W035376

m-PEG6-CH2CH2CHO	ADC Linker PROTAC Linkers	Cancer
m-PEG6-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-112099

Mc-Val-Cit-PAB-Cl	ADC Linker	Cancer
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC₅₀s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

HY-130151

m-PEG7-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
m-PEG7-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-136234

9-cis-β-Carotene	Others	Others
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus.

HY-122611

CSRM617	Androgen Receptor Apoptosis	Cancer
CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-139018

TLR7/8 agonist 4 hydroxy-PEG10-acid	Drug-Linker Conjugates for ADC	Cancer
TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the cleavable ADC linker hydroxy-PEG10-acid (HY-133307).

HY-139018A

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride	Drug-Linker Conjugates for ADC	Cancer
TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the cleavable ADC linker hydroxy-PEG10-acid (HY-133307).

HY-122611A

CSRM617 hydrochloride	Androgen Receptor Apoptosis	Cancer
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

HY-D1578

C12FDGlcU	Fluorescent Dye	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of β-glucuronidase (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm).

HY-146957

ZIKV-IN-1	Virus Protease	Cancer
ZIKV-IN-1 is a potent zika virus inhibitor with an EC₅₀ of 2.8 µM and EC₉₀ of 6.8 µM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain.

HY-146980

GLUT4-IN-2	Apoptosis GLUT	Cancer
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC₅₀s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity.

HY-130167

Fmoc-NH-PEG9-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W040238

Fmoc-NH-PEG2-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG2-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W007713

Fmoc-8-amino-3,6-dioxaoctanoic acid Fmoc-NH-PEG2-CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-153116

BT8009	Others	Cancer
BT8009 is a Nectin-4 targeting toxin conjugate with a K_d value of 2.5 nmol/L for human Nectin-4 (hNectin-4) extra-cellular domain (ECD). BT8009 consists of a Nectin-4-binding bicyclic peptide, a cleavable linker system and monomethylauristatin E (MMAE). BT8009 can be used for the research of advanced and metastatic urothelial cancer.

HY-129942

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate	ADC Linker	Cancer
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes.

HY-124386

DBCO-NHCO-PEG4-amine	ADC Linker PROTAC Linkers	Cancer
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively).

HY-W040231

Fmoc-NH-PEG3-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W040244

Boc-NH-PEG6-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W000434

Fmoc-NH-PEG4-CH2CH2COOH Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid	ADC Linker PROTAC Linkers	Cancer
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W035378

Fmoc-N-methyl-PEG3-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W040132

Boc-NH-PEG4-CH2CH2COOH	PROTAC Linkers ADC Linker	Cancer
Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).

HY-42149

NH2-PEG2-C2-Boc	PROTAC Linkers ADC Linker	Cancer
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W411215

1,4-Diacetoxy-2,3-dicyanobenzene	Fluorescent Dye	Others
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH.

HY-138298A

Trastuzumab deruxtecan DS-8201; DS-8201a	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, and a topoisomerase I inhibitor. Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer.

HY-P1883A

Bacterial Sortase Substrate III, Abz/DNP TFA	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-130293

Propargyl-PEG4-CH2CH2-Boc	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-13721

Phenoxodiol Idronoxil; Dehydroequol; Haginin E	Caspase Apoptosis Topoisomerase	Cancer
Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21^WAF1 via a p53 independent manner.

HY-145065

Enpp-1-IN-7	Phosphodiesterase (PDE)	Cancer Infection
Enpp-1-IN-7 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-7 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51).

HY-126975

Propargyl-PEG3-acid	ADC Linker PROTAC Linkers	Cancer Inflammation/Immunology
Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid.

HY-138298

Trastuzumab deruxtecan (solution) DS-8201 (solution); DS-8201a (solution)	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan (solution) is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, and a topoisomerase I inhibitor. Trastuzumab deruxtecan (solution) can be used for the research of HER2-positive breast cancer and gastric cancer.

HY-145064

Enpp-1-IN-6	Phosphodiesterase (PDE)	Cancer Infection
Enpp-1-IN-6 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-6 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51).

HY-135799

WH-15	Phospholipase	Cancer Neurological Disease
WH-15 is a fluorogenic PLC reporter with K_m value of 49; 30, 86.1 µM for PLC-γ1, PLC-δ1, PLC-β2, respectively. WH-15 can be cleaved in a cascade reaction to generate fluorescent 6-aminoquinoline. WH-15 can be used to respond to imaging PLC activity in live cells.

HY-145070

Enpp-1-IN-9	Phosphodiesterase (PDE)	Cancer Infection
Enpp-1-IN-9 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-9 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51).

HY-130426

Maleimido-tri(ethylene glycol)-propionic acid Mal-PEG3-acid	ADC Linker PROTAC Linkers	Cancer
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P1829

Angiotensin I/II (1-6)	Angiotensin Receptor	Cardiovascular Disease
Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

HY-145069

Enpp-1-IN-8	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-8 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-8 has the potential for the research of cancer and infectious diseases (extracted from patent WO2021203772A1, compound 51).

HY-N1970

5,7-Dihydroxychromone	Keap1-Nrf2 Arenavirus Caspase PARP	Neurological Disease
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells.

HY-42490

N3-PEG3-CH2CH2COOH	PROTAC Linkers ADC Linker	Cancer Inflammation/Immunology
N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-W021787

NH2-PEG4-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-13240

LY2886721	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active *beta-site amyloid precursor protein cleaving* enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀** of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

HY-130161

m-PEG4-Br	ADC Linker PROTAC Linkers	Cancer
m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W008352

Boc-NH-PEG4-CH2CH2NH2	ADC Linker PROTAC Linkers	Cancer
Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-114816S

N-butyryl-L-Homoserine lactone-d5	ADC Linker Bacterial	Infection Inflammation/Immunology
N-butyryl-L-Homoserine lactone-d₅ is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

HY-141852

STAMBP-IN-1	Deubiquitinase	Inflammation/Immunology
STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC₅₀ value of 0.33 mM.

HY-W040257

NH2-PEG6-CH2CH2COOH	ADC Linker PROTAC Linkers	Cancer
NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P99683

Ladiratuzumab vedotin SGN-LIV1A	Antibody-Drug Conjugates (ADCs)	Cancer
Ladiratuzumab vedotin (SGN-LIV1A) is a LIV-1 targeting antibody drug conjugate (ADC) (IC₅₀: 5.6 nM for LIV-1). Ladiratuzumab vedotin consists of humanized IgG1 monoclonal antibody, MMAE and a protease-cleavable linker. Ladiratuzumab vedotin can drive immunogenic cell death (ICD) to elicit an immune response. Ladiratuzumab vedotin can be used for research of breast cancer.

HY-P1829A

Angiotensin I/II (1-6) (TFA)	Angiotensin Receptor	Cardiovascular Disease
Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

HY-136742

BACE2-IN-1	Beta-secretase	Metabolic Disease
BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Kⁱ value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes.

HY-W039442

2′-Deoxy-2′-fluoroadenosine	Nucleoside Antimetabolite/Analog	Cancer
2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP.

HY-145063

Enpp-1-IN-5	Phosphodiesterase (PDE)	Cancer Infection Inflammation/Immunology
Enpp-1-IN-5 is a potent inhibitor of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1). The ENPP 1 has broad specificity and can cleave a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds nucleotides and nucleotide sugars. Enpp-1-IN-5 has the potential for the research of cancer and infectious diseases (extracted from patent WO2019046778A1/WO2021203772A1, compound 1).

HY-113764

N-Butanoyl-DL-homoserine lactone (Rac)-C4-HSL	Bacterial	Infection Inflammation/Immunology
N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a racemic mixture of N-Butanoyl-D-homoserine lactone and N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.

HY-140213

Azido-PEG2-C2-amine N3-PEG2-CH2CH2NH2	PROTAC Linkers ADC Linker	Cancer
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-123931

ZLDI-8	Notch Phosphatase Apoptosis	Cancer
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC₅₀ of 31.6 μM and a K_i of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC₅₀ of 5.32 μM.

HY-151837

H-L-Phe(4-NH-Poc)-OH hydrochloride	ADC Linker	Others
H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported.

HY-151824

Boc-L-Phe(4-NH-Poc)-OH	ADC Linker	Others
Boc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in peptide synthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported.

Cat. No.	Product Name	Type

HY-15934

X-GAL
BCIG
Chromogenic Substrates

X-GAL is a widely used chromogenic β-galactosidase substrate. β-galactosidase cleaves X-gal and produce an insoluble blue compound, which is detectable.

HY-D1678

5(6)-Carboxynaphthofluorescein diacetate	Fluorescent Dyes/Probes
5(6)-Carboxynaphthofluorescein diacetate is a fluorescent substrate for esterase assays that can be cleaved by intracellular esterases, producing red fluorescence to measure enzyme activity (Ex = 590 nm; Em = 645 nm).

HY-111496

Sulfo-NHS-SS-Biotin sodium	Dyes
Sulfo-NHS-SS-biotin is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin can be used for the labeling and purifying of cell-surface protein.

HY-137845

4-Methylumbelliferyl β-D-galactopyranoside	Fluorescent Dyes/Probes
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer.

HY-126561

Green CMFDA CMFDA	Fluorescent Dyes/Probes
Green CMFDA (CMFDA) is a cell-permeable fluorescent probe that can be used a cell tracer. Green CMFDA can be cleaved by non-specific esterases common to living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope.

HY-145383

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide	Protein Labeling
Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide. Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is an enrichment handle of cell surface glycoproteins for protein labeling.

HY-131498

MOCAc-PLGL(Dpa)AR	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues.

HY-P3110

Ac-DNLD-AMC	Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.

HY-W320032

5-Bromo-1H-indol-3-yl octanoate	Chromogenic Substrates
5-Bromo-1H-indol-3-yl octanoate is a chromogenic substrate for esterase with C8 activity. 5-Bromo-1H-indol-3-yl octanoate yields a blue precipitate when cleaved.

HY-D1578

C12FDGlcU	Fluorescent Dyes/Probes
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of β-glucuronidase (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm).

HY-W411215

1,4-Diacetoxy-2,3-dicyanobenzene	Fluorescent Dyes/Probes
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH.

Cat. No.	Product Name	Type

HY-129046

Ribonuclease A RNase A	Enzyme
Ribonuclease A cleaves RNA 3′ to pyrimidines and actively cleaves RNA at every pyrimidine residue. Ribonuclease A catalyzes the hydrolysis of single stranded RNA in the absence of metal ions or cofactors.

HY-E70017

Peptidase
Erepsin
Enzyme

Peptidase(Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis.

HY-E70018

Picornain 3C

Enzyme

Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses.

HY-108910

Chymotrypsin Chymotrypsin A	Biochemical Assay Reagents
Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids.

HY-E70023

Sphingolipid ceramide N-deacylase SCDase	Enzyme
Sphingolipid ceramide N-deacylase (SCDase) cleaves the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids. Sphingolipid ceramide N-deacylase catalyzes glycosphingolipids to lysoglycosphingolipids.

HY-P3150

Recombinant Proteinase K	Biochemical Assay Reagents
Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations.

HY-P2988

Neuraminidase Exo-α-sialidase	Enzyme
Neuraminidase (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection.

HY-P2834

Penicillin amidase Penicillin acylase	Enzyme
Penicillin amidase (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics.

HY-E70029

alpha-1,6-Fucosidase	Enzyme
alpha-1,6-Fucosidase cleaves branched non-reducing terminal fucose, linked α(1-6) to the core N-acetylglucosamine of N-linked oligosaccharides. alpha-1,6-Fucosidase is useful for determining core fucosylation.

HY-P2963

Nuclease P1	Enzyme
Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries.

HY-P3017

Endo-1,4-β-xylanase Xylanase; CtXyn11A; EC 3.2.1.8	Enzyme
Endo-1,4-β-xylanase (Xylanase) is an arabinoxylan (AX) degrading enzyme and a glycoside hydrolase, is often used in biochemical studies. Endo-1,4-β-xylanase cleaves the β-xylosidic bond between two d-xylopyranosyl residues linked in β-(1,4).

HY-P2810

Rennin

Enzyme

Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production.

Cat. No.	Product Name	Target	Research Area

HY-P3159

VPM peptide	Biochemical Assay Reagents	Others
VPM peptide is a dithiol protease-cleavable peptide cross-linker. VPM peptide can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel.

HY-P3159A

VPM peptide TFA	Biochemical Assay Reagents	Others
VPM peptide TFA is a dithiol protease-cleavable peptide cross-linker. VPM peptide TFA can be incorporated into the backbone of the PEG-diacrylate (PEG-DA) macromer to form PEG hydrogel.

HY-W016887

H-Gly-Pro-OH
Endogenous Metabolite Metabolic Disease

H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
HY-P3950

Fluorescent Substrate for Asp-Specific Proteases
Fluorescent Dye Others

Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond.

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-P1484

Bradykinin (1-7) Bradykinin Fragment 1-7	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

HY-P1032

Angiotensin I (human, mouse, rat)	Endogenous Metabolite	Others
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

HY-P1490

Bradykinin (2-9) Des-Arg1-bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

HY-P1469

Bradykinin (1-6)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).

HY-P3208

Endoproteinase Lys-C
Peptides Others

Endoproteinase Lys-C is a protease that cleaves proteins on the C-terminal side of lysine residues and is commonly used for protein sequencing.

HY-P1497

Bradykinin (1-3)	Bradykinin Receptor	Cardiovascular Disease Endocrinology
Bradykinin (1-3) is a 3-amino acid residue peptide. Bradykinin (1-3) is an amino-truncated Bradykinin peptide, cleaved by Prolyl endopeptidase.

HY-P1449

Boc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-136432A

Mc-Gly-Gly-Phe-Gly-PAB-OH TFA
Mc-GGFG-PAB-OH TFA
ADC Linker Cancer

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) TFA is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

HY-P1449A

Boc-Gly-Gly-Phe-Gly-OH TFA	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-P1538

Fibrinopeptide A, human Human fibrinopeptide A	Peptides	Cardiovascular Disease
Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain.

HY-P1538A

Fibrinopeptide A, human TFA Human fibrinopeptide A TFA	Peptides	Cardiovascular Disease
Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain.

HY-W141916

Pentaglycine Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Peptides	Infection
Pentaglycine (Tetraglycylglycine) is a bridge containing five glycine molecules. Pentaglycine can form highly cross-linked peptidoglycan. Glucose reduced expression of pentaglycine. Pentaglycine is cleaved by lysostaphin, and occurs in the cell envelope of staphylococci.

HY-136626

Z-Ala-Ala-Asn-AMC Cbz-Ala-Ala-Asn-AMC	Peptides	Cancer
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC.

HY-P1241

BAM(8-22)	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

HY-P1241A

BAM(8-22) TFA	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
BAM(8-22) TFA, a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

HY-P0122

iRGD peptide c(CRGDKGPDC)	Integrin	Cancer
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of drugs by first binding to av integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.

HY-P2988

Neuraminidase Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection.

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.

HY-P4139

activable cell-penetrating peptide (ACCP)	Peptides	Others
activable cell-penetrating peptide (ACCP) consists of a polycationic CPP (typically arg9 or r9) connected via a cleavable linker to a matching polyanion (typically glu9 or e9), which reduces the net charge to nearly zero and thereby inhibits adhesion and uptake into cells.

HY-P2963

Nuclease P1	Endogenous Metabolite	Others
Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries.

HY-P3602

C3 Peptide P16	Peptides	Cancer
C3 Peptide P16, is a 16 amino acid synthetic peptide derived from human C3d, a fragment generated in trypsin-cleaved C3. C3 Peptide P16 enhances in vitro phosphorylation of pp105 and pp100, a cellular component presenting in the human B lymphoma cells.

HY-P3017

Endo-1,4-β-xylanase Xylanase; CtXyn11A; EC 3.2.1.8	Poly(ADP-ribose) Glycohydrolase (PARG)	Others
Endo-1,4-β-xylanase (Xylanase) is an arabinoxylan (AX) degrading enzyme and a glycoside hydrolase, is often used in biochemical studies. Endo-1,4-β-xylanase cleaves the β-xylosidic bond between two d-xylopyranosyl residues linked in β-(1,4).

HY-P2821

Plasminogen	Peptides	Inflammation/Immunology
Plasminogen is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia.

HY-P2810

Rennin	Endogenous Metabolite Ser/Thr Protease	Metabolic Disease
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production.

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P1883A

Bacterial Sortase Substrate III, Abz/DNP TFA	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P1829

Angiotensin I/II (1-6)	Angiotensin Receptor	Cardiovascular Disease
Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

HY-P1829A

Angiotensin I/II (1-6) (TFA)	Angiotensin Receptor	Cardiovascular Disease
Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

Cat. No.	Product Name	Target	Research Area

HY-P99593

Sofituzumab vedotin DMUC5754A	Antibody-Drug Conjugates (ADCs)	Cancer
Sofituzumab vedotin (DMUC5754A) is a MMAE-containing anti-MUC16 antibody-drug conjugate (ADC) with a protease-cleavable linker. Sofituzumab vedotin can be used for the research of cancer.

HY-P99734

Mipasetamab uzoptirine ADCT-601	TAM Receptor	Cancer
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers.

HY-P99774

Pivekimab sunirine IMGN 632; PVEK	Antibody-Drug Conjugates (ADCs)	Cancer
Pivekimab sunirine (IMGN 632) is an antibody-drug conjugate (ADC) targeting CD123. Pivekimab sunirine comprises a high-affinity CD123 antibody, cleavable linker, and an indolinobenzodiazepine pseudodimer (IGN) payload. Pivekimab sunirine can be used for research of hematological malignancies.

HY-P99050

Sutimlimab	Complement System	Inflammation/Immunology Cardiovascular Disease
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase.

HY-P9985

Disitamab vedotin RC48	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.

HY-P99547

Trastuzumab duocarmazine (vic)-Trastuzumab duocarmazine	Antibody-Drug Conjugates (ADCs)	Cancer
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas.

HY-P99595

Sirtratumab vedotin AGS15E; ASG-15ME; 1vcMMAE	Antibody-Drug Conjugates (ADCs)	Cancer
Sirtratumab vedotin (ASG15-ME) is an ADC composed of a SLITRK6-specific human gamma 2 antibody (Igγ2) conjugated to a small molecule microtubule disrupting agent, monomethyl auristatin E (MMAE) via a protease-cleavable linker.

HY-P99813

Patritumab deruxtecan HER3-DXd; U3-1287	Antibody-Drug Conjugates (ADCs)	Cancer
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.

HY-138298A

Trastuzumab deruxtecan DS-8201; DS-8201a	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, and a topoisomerase I inhibitor. Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer.

HY-138298

Trastuzumab deruxtecan (solution) DS-8201 (solution); DS-8201a (solution)	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Trastuzumab deruxtecan (DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan (solution) is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, and a topoisomerase I inhibitor. Trastuzumab deruxtecan (solution) can be used for the research of HER2-positive breast cancer and gastric cancer.

HY-P99683

Ladiratuzumab vedotin SGN-LIV1A	Antibody-Drug Conjugates (ADCs)	Cancer
Ladiratuzumab vedotin (SGN-LIV1A) is a LIV-1 targeting antibody drug conjugate (ADC) (IC₅₀: 5.6 nM for LIV-1). Ladiratuzumab vedotin consists of humanized IgG1 monoclonal antibody, MMAE and a protease-cleavable linker. Ladiratuzumab vedotin can drive immunogenic cell death (ICD) to elicit an immune response. Ladiratuzumab vedotin can be used for research of breast cancer.

Cat. No.	Product Name	Target	Category

HY-W016887

H-Gly-Pro-OH	Endogenous Metabolite	Alkaloids Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

HY-W034918

Docosanedioic acid	ADC Linker PROTAC Linkers	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-N1988

Cucurbitacin IIa Hemslecin A	Survivin Apoptosis	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Cucurbitaceae Hemsleya chinensis Cogn. ex Forbes et Hemsl.
Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells.

HY-N6800A

Netropsin dihydrochloride	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus	Inflammation/Immunology Disease Research Fields Classification of Application Fields
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus.

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Microtubule/Tubulin Beta-secretase Apoptosis	Alkaloids Isoquinoline Alkaloids Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

HY-108966

Kushenol C	Beta-secretase	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Leguminosae Sophora flavescens
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits *BACE1 (β-site APP cleaving* enzyme 1) with an IC₅₀** of 5.45 µM.

HY-N11322

Bitis Arietans Venom Puff Adder Venom	Others	Snake Venoms Animals Animal Venoms
Bitis Arietans Venom (Puff Adder Venom) is a snake venom that can be obtained from Bitis Arietans. Bitis Arietans Venom inhibits platelet aggregation. The fibrinogenase can be purified from the Bitis Arietans Venom, and cleaves the Aα and Bβ chain of fibrinogen.

HY-113354

Anserine	Endogenous Metabolite	Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease markers Nervous System Disorder Immune System Disorder
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.

HY-N8481

3,6-Dihydroxyflavone 3,6-DHF	Apoptosis	Flavonoids Flavonols Phenols Monophenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation.

HY-N1970

5,7-Dihydroxychromone	Keap1-Nrf2 Arenavirus Caspase PARP	Isoflavones Phenols Polyphenols Flavonoids Source classification Plants other families
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells.

Cat. No.	Product Name

HY-113354S

Anserine-d4

Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-114816S

N-butyryl-L-Homoserine lactone-d5

N-butyryl-L-Homoserine lactone-d₅ is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

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