congenital

By Targets:	CFTR (3) CMV (1) CRFR (1) Endogenous Metabolite (2) HCN Channel (1) Integrin (1) Isotope-Labeled Compounds (1) Orthopoxvirus (1) Sirtuin (1)
By Research Areas:	Cancer (1) Endocrinology (3) Infection (1) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (1)
Click Chemistry:	Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113405

21-Deoxycortisol

Endogenous Metabolite Endocrinology

21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

21-Deoxycortisol	Endogenous Metabolite	Endocrinology
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research . Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-107935

6α-Fluoroprednisolone Fluprednisolone	Others	Inflammation/Immunology
6α-Fluoroprednisolone (Fluprednisolone) is an internal standard for methylprednisolone, prednisolone and prednisone. 6α-Fluoroprednisolone is an anti-inflammatory agent. 6α-Fluoroprednisolone can be used for congenital adrenal virilism and Addison's disease research .

HY-156522

CRF1 receptor antagonist-1	CFTR	Endocrinology
CRF1 receptor antagonist-1 (Compound 2) is a CRF1 receptor antagonist. CRF1 receptor antagonist-1 can be used for research of congenital adrenal hyperplasia (CAH) .

HY-106203

Crinecerfont SSR-125543	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138802

ML089	Others	Metabolic Disease
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC₅₀ of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .

HY-109525

Sacrosidase	Others	Metabolic Disease
Sacrosidase is a yeast-derived enzyme that facilitates sucrose digestion. Sacrosidase has the potential for congenital sucrase-isomaltase (SI) deficiency research .

HY-113405S1

21-Deoxycortisol-d8	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].

HY-119102

BPU-11	HCN Channel	Inflammation/Immunology
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease .

HY-113603

Tildacerfont SPR001; LY2371712	CRFR	Cancer
Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia .

HY-147014

Cyclic HPMPC	CMV Orthopoxvirus	Infection
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model .

HY-136234

9-cis-β-Carotene	Others	Others
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. 9-cis-β-Carotene inhibits photoreceptor degeneration and restores retinal function in vivo. 9-cis-β-Carotene has the potential for the study of congenital stationary night blindness and fundus albipunctatus .

HY-16361A

Omigapil maleate CGP3466B; CGP3446 maleate; TCH346 maleate
Omigapil maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ_1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease . Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124890

Thr101	Others	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

HY-P3227

Cyclo(Ala-Arg-Gly-Asp-Mamb) XJ735	Integrin	Inflammation/Immunology
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension Research .

HY-111303

CHIC35	Sirtuin	Neurological Disease Inflammation/Immunology
CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC₅₀=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC₅₀=2.8 µM) or SIRT3 (IC₅₀>100 µM) . CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research .

Cat. No.	Product Name	Target	Research Area

HY-P1360

H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe	Peptides	Metabolic Disease
H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a nonimmunosuppressive cyclosporin A derivative. H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe has the potential for the research of congenital muscular dystrophy .

HY-P3227

Cyclo(Ala-Arg-Gly-Asp-Mamb) XJ735	Integrin	Inflammation/Immunology
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension Research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113405

21-Deoxycortisol	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

Species:	Human (2)
Tag:	His (2) SUMO (1)
Source:	E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702280

	FKTN Protein, Human (Cell-Free, His) Ribitol-5-phosphate transferase FKTN; Fukutin; Fukuyama-type congenital muscular dystrophy protein; Ribitol-5-phosphate transferase	Human	E. coli Cell-free
	The FKTN protein catalyzes the transfer of ribitol phosphate from CDP-ribitol to the distal N-acetylgalactosamine in the phosphorylated O-mannosyl trisaccharide of α-dystroglycan (DAG1). FKTN Protein, Human (Cell-Free, His) is the recombinant human-derived FKTN protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of FKTN Protein, Human (Cell-Free, His) is 461 a.a., with molecular weight of 56.5 kDa.

HY-P700595

	PRPS1 Protein, Human (His-SUMO) PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital , DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1	Human	E. coli
	The PRPS1 protein plays a crucial role in catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key intermediate in nucleotide synthesis. By promoting the conversion of ribose 5-phosphate and ATP to PRPP, PRPS1 contributes to the availability of PRPP in various cellular processes, including de novo biosynthesis of purine and pyrimidine nucleotides. PRPS1 Protein, Human (His-SUMO) is the recombinant human-derived PRPS1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PRPS1 Protein, Human (His-SUMO) is 317 a.a., with molecular weight of 50.7 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-113405S1

21-Deoxycortisol-d8
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia[1].

Cat. No.	Product Name	Application	Reactivity

HY-P81047

Collagen II Antibody Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.; CollagenII;	WB, ELISA, IHC-P, IF	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
Collagen II Antibody is an unconjugated, approximately 117 KDa, rabbit-derived, anti-Collagen II polyclonal antibody. Collagen II Antibody can be used for: WB, ELISA, IHC-P, IF expriments in human, mouse, rat, chicken, dog, pig, cow, rabbit, guinea pig background without labeling.

Cat. No.	Product Name		Classification

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride		Alkynes
Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research . Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203

Crinecerfont SSR-125543		Alkynes
Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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congenital

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