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Results for "

considerable

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) Autophagy (1) Bacterial (4) BCL6 (1) Beta-lactamase (2) Beta-secretase (2) Cholinesterase (ChE) (2) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Epigenetic Reader Domain (2) Fungal (4) HSP (1) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Mitochondrial Metabolism (2) mTOR (1) Oxidative Phosphorylation (2) PROTACs (1) Reactive Oxygen Species (1) ROS Kinase (2)
By Research Areas:	Cancer (12) Infection (5) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (3)

By Targets:

5-HT Receptor (1)

Apoptosis (2)

Autophagy (1)

Bacterial (4)

BCL6 (1)

Beta-lactamase (2)

Beta-secretase (2)

Cholinesterase (ChE) (2)

DNA/RNA Synthesis (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (2)

Fungal (4)

HSP (1)

HSV (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (2)

mTOR (1)

Oxidative Phosphorylation (2)

PROTACs (1)

Reactive Oxygen Species (1)

ROS Kinase (2)

By Research Areas:

Cancer (12)

Infection (5)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0415S

Trigonelline-d3 chloride Trigonelline-d₃ hydrochloride	Isotope-Labeled Compounds HSV Bacterial Fungal	Infection Metabolic Disease Cancer
Trigonelline-d₃ (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.

HY-100589

Isepamicin sulfate Sch 21420 sulfate
Isepamicin sulfate (Sch 21420 sulfate) is a broad spectrum aminoglycoside antibiotic. Isepamicin sulfate exhibits considerable antimicrobial activity against Gram-negative non-fermenters in a region with high antimicrobial resistance .

HY-145870

Anti-inflammatory agent 13	Others	Inflammation/Immunology
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation .

HY-132925

Antifungal agent 16	Fungal	Infection
Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.

HY-144236

ZLD2218	Epigenetic Reader Domain	Others
Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis ，and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC₅₀ value of 107 nM

HY-N7605

11-epi-mogroside V	Others	Metabolic Disease
11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro .

HY-115996

Antitumor agent-51	Others	Cancer
Antitumor agent-51 possesses potent and selective inhibitory for osteosarcoma cell growth and migration with IC₅₀ of 21.9 nM in MNNG/HOS cells. Antitumor agent-51 has a considerable bioavailability and a low toxicity .

HY-N12122

Dehydropipernonaline	Fungal	Neurological Disease
Dehydropipernonaline (Compound 24) is an amide compound. Dehydropipernonaline shows considerable cytotoxicity to L5178Y mouse lymphoma cells (IC₅₀8.9μM). Dehydropipernonaline can be used for screening antifungal and cytotoxicity .

HY-N1521

Rehmannic acid Lantadene A	Others	Inflammation/Immunology
Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent .

HY-103101

LP44 hydrochloride	5-HT Receptor	Others
LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration .

HY-142743

Y08175	Epigenetic Reader Domain	Cancer
Y08175 is a potent CBP bromodomain inhibitor. Y08175 exhibits considerable inhibitory effect with IC₅₀s of 37 and 178.15 nM against CBP bromodomain in AlphaScreen assay and HTRF assay, respectively. Y08175 can be used for the research of prostate cancer .

HY-145674

HDP 30.1699	Others	Cancer
HDP 30.1699, the derivative of α-Amanitin, shows considerable cross-links. The cysteine residues of the anti-HER2 THIOMAB antibody are used for conjugation of the cysteine reactive linker–Amanitin compound, HDP 30.1699, with a cleavable linker by maleimide chemistry .

HY-N9912

Physalin D	Others	Cancer
Physalin D is isolated from the aerial parts of Physalis angulate. Physalin D displays considerable cytotoxicity against several cancer cell lines, showing IC₅₀ values in the range of d 0.28 to 2.43 microg/mL. Physalin D has the potential for the cancer disease .

HY-100768

HTHQ 2 Publications Verification 1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105	Reactive Oxygen Species	Cancer
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals .

HY-155554

SCAL-255	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC₅₀ of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-155555

SCAL-266	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC₅₀ of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-139745

FPI-1523 sodium	Beta-lactamase Bacterial	Infection
FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with K_ds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC₅₀ of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity .

HY-139745A

FPI-1523	Beta-lactamase Bacterial	Infection
FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with K_ds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC₅₀ of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity .

HY-134460

4-Methylumbelliferyl α-L-fucopyranoside	Endogenous Metabolite	Others
4-Methylumbelliferyl α-L-fucopyranoside is an α-L-fucosidase. α-L-fucosidase can enhance capacitation of porcine sperm and protect sperm from premature acrosome reaction. Compared with human liver α-L-fucosidase, 4-Methylumbelliferyl α-L-fucopyranoside has considerable hydrophobicity and isoelectric focusing properties .

HY-W013053

Dibenz[a,h]anthracene DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene	DNA/RNA Synthesis Apoptosis MDM-2/p53	Cancer
Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-147944

Antimicrobial agent-4	Bacterial Fungal	Infection
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent. Antimicrobial agent-4 exhibits considerable activity against the microbial pathogens. Antimicrobial agent-4 delivers reliable toxicity to kill the bacteria and fungi. Antimicrobial agent-4 shows high binding energy value of −10.0 kcal/mole against the target enzyme .

HY-146674

IDO1/TDO-IN-3	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC₅₀: 0.005 μM) and TDO (IC₅₀: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed .

HY-158105

ARV-393	PROTACs BCL6	Cancer
ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC₅₀ and GI₅₀ values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.

HY-147659

AChE/BChE/BACE-1-IN-2	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC₅₀ values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential .

HY-147658

AChE/BChE/BACE-1-IN-1	Cholinesterase (ChE) Beta-secretase ROS Kinase	Neurological Disease
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC₅₀ values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential .

HY-151137

HSP90/mTOR-IN-1	mTOR HSP Apoptosis Autophagy	Cancer
HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC₅₀ values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer .

Hydrin 1′	Peptides	Others
Hydrin 1′ is found in the neurohypophysis of Xenopus. Hydrin 1′ possesses a considerable steroid-releasing activity in Xenopus adrenal gland in vitro .

Cat. No.	Product Name	Category	Target	Chemical Structure