cytoskeletal

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Bacterial (1) Endogenous Metabolite (1) PAK (3) Ras (1) TRP Channel (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1411

i-Inositol myo-Inositol; meso-Inositol	Endogenous Metabolite	Others
i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role .

HY-N2438

Methylophiopogonanone B	Ras	Others
Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability . Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation .

HY-13007

PF-3758309 Maximum Cited Publications 7 Publications Verification PF-03758309	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007B

PF-3758309 dihydrochloride PF-03758309 dihydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007A

PF-3758309 hydrochloride PF-03758309 hydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-133012

GFB-8438	TRP Channel	Neurological Disease
GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC₅₀s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model .

HY-150754

FtsZ-IN-4	Bacterial	Infection
FtsZ-IN-4 is an orally active FtsZ (filamenting temperature-sensitive mutant Z) inhibitor, exhibits excellent antibacterial activity. FtsZ-IN-4 shows good pharmaceutical properties with low cytotoxicity (CC₅₀ >20 μg/mL) .

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library	1254 compounds
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 1254 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cytoskeleton Compound Library

1254 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1254 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1411

i-Inositol myo-Inositol; meso-Inositol	Structural Classification Natural Products Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Disease markers Other Diseases Disease Research Fields	Endogenous Metabolite
i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role .

HY-N2438

Methylophiopogonanone B	Ophiopogon japonicus (L. f.) Ker-Gawl. Flavonoids Liliaceae Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Other Flavonoids Disease Research Fields	Ras
Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability . Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation .

Species:	Human (2)
Tag:	His (2) Myc (1)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71668

	KRT18 Protein, Human (HEK293, His) Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46 ; Keratin D ; keratin, type I cytoskeletal 18; Keratin-18; Krt18	Human	HEK293
	The KRT18 protein is a heterotetramer with KRT8 that has multiple roles, including uptake of thrombin-antithrombin complexes and assisting in the delivery of mutated CFTR to the plasma membrane. It cooperates with KRT8 in IL-6-mediated barrier protection and interacts with PLEC isoform 1C. KRT18 Protein, Human (HEK293, His) is the recombinant human-derived KRT18 protein, expressed by HEK293 , with N-10*His labeled tag. The total length of KRT18 Protein, Human (HEK293, His) is 429 a.a., with molecular weight of ~50.8 kDa.

HY-P72052

	KRT8 Protein, Human (Baculovirus, His-Myc) CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8 ; Keratin; type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8	Human	Sf9 insect cells
	The KRT8 protein, in cooperation with KRT19, critically links the contractile apparatus of the striated rib muscle to dystrophin. This heterotetramer consists of two type I keratins and two type II keratins, forming a heterodimer with KRT18. KRT8 Protein, Human (Baculovirus, His-Myc) is the recombinant human-derived KRT8 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of KRT8 Protein, Human (Baculovirus, His-Myc) is 483 a.a., with molecular weight of ~57.6 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Application	Reactivity

HY-P82926

Cytokeratin 2e Antibody (YA2671) KRT2; KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84; Keratin; type II cytoskeletal 2 epidermal; Keratin; type II cytoskeletal 2 oral; Keratin; type II cytoskeletal 3; Keratin; type II cytoskeletal 5; Keratin; type II cytoskeletal 6A; Keratin; type II cytoskeletal 6B; Keratin; type II cytoskeletal 6C; Keratin; type II cytoskeletal 71; Keratin; type II cytoskeletal 72; Keratin; type II cytoskeletal 73; Keratin; type II cytoskeletal 74	WB, IHC-P	Human

HY-P83259

Cytokeratin 12 Antibody (YA3004)

K12; Keratin 12; KRT12; type I cytoskeletal 12
WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82789

Cytokeratin 17 Antibody (YA2534)

Keratin; type I cytoskeletal 17; Cytokeratin-17; CK-17; Keratin-17; K17
WB, IHC-P, IP Human
HY-P82131

Cytokeratin 14 Antibody (YA1876)

KRT14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14
WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82112

Cytokeratin 10 Antibody (YA1857)

KRT10; KPP; Keratin; type I cytoskeletal 10; Cytokeratin-10; CK-10; Keratin-10; K10
WB, IHC-P Human, Hamster, Mouse, Rat
HY-P81266

Cytokeratin 16 Antibody (YA948)

KRT16; KRT16A; Keratin; type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
WB, IHC-P Human, Mouse, Rat
HY-P81266A

Cytokeratin 16 Antibody (YA949)

KRT16; KRT16A; Keratin; type I cytoskeletal 16; Cytokeratin-16; CK-16; Keratin-16; K16
WB, IHC-P Human
HY-P82950

Cytokeratin 13 Antibody (YA2695)

Keratin; type I cytoskeletal 13; Krt1-13; Cytokeratin 13; CK13; Keratin 13; KRT13; WSN2
WB, IHC-P, ICC/IF Human, Mouse
HY-P83260

Cytokeratin 8 Antibody (YA3005)

KRT8; CYK8; Keratin; type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
WB, IHC-P, ICC/IF, IP, FC Human, Mouse
HY-P82890

Phospho-Cytokeratin 8 (Ser23) Antibody (YA2635)

KRT8; CYK8; Keratin; type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
WB, IHC-F, IHC-P, ICC/IF, IP Human

HY-P81183

Cytokeratin 19 Antibody 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit)
Cytokeratin 19 Antibody is an unconjugated, approximately 44 kDa, rabbit-derived, anti-Cytokeratin 19 polyclonal antibody. Cytokeratin 19 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, and predicted: rat, chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P81250

Cytokeratin 19 Antibody (YA924) 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd	WB, IHC-P, IHC-F, ICC, IF	Rat, Mouse, Human
Cytokeratin 19 Antibody is an unconjugated, approximately 44 kDa, mouse-derived, anti-Cytokeratin 19 monoclonal antibody. Cytokeratin 19 Antibody can be used for: WB, IHC-P, IHC-F,ICC, IF expriments in human, mouse, rat background without labeling.

HY-P81181

CK18 Antibody K1C18_HUMAN; Keratin, type I cytoskeletal 18; KRT18; CYK18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18 (CK-18); Keratin-18 (K18); PIG46; Keratin 18	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Dog, Pig, Cow, Horse, Rabbit)
CK18 Antibody is an unconjugated, approximately 48 kDa, rabbit-derived, anti-CK18 polyclonal antibody. CK18 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, horse, rabbit background without labeling.

HY-P81748

Cytokeratin 15 Antibody (YA1493) CK-15; CK15; cytokeratin15; K15; K1C15; K1CO; keratin 15; Keratin-15; keratin-15; beta; KRT15; KRTB; type I cytoskeletal 15	WB, IHC-P, ICC/IF, FC	Human, Mouse

HY-P81267

Cytokeratin 7 Antibody (YA950) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type ii cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, ICC/IF	Human

HY-P81267A

Cytokeratin 7 Antibody (YA951) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type ii cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P81267B

Cytokeratin 7 Antibody (YA952) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k type ii cytoskeletal; Keratin 7; Keratin simple epithelial type 1 k7; Keratin type II cytoskeletal 7	WB, ICC/IF, IP	Human

HY-P80984

Cytokeratin 5 Antibody CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; type II cytoskeletal 5 ; Type-II keratin Kb5;	WB, IHC-P, IF-Tissue, IF-Cell, FC	Human, Mouse, Rat
Cytokeratin 5 Antibody is an unconjugated, approximately 62 kDa, rabbit-derived, anti-Cytokeratin 5 monoclonal antibody. Cytokeratin 5 Antibody can be used for: WB, IHC-P, IF-Tissue, IF-Cell, FC expriments in human, mouse, rat background without labeling.

HY-P82920

Cytokeratin 1 Antibody (YA2665) 67 kDa cytokeratin; CK1; EHK; Epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; Keratin; KRT 1; KRT1A; NEPPK; type II cytoskeletal 1; Type-II keratin Kb1	WB	Human, Mouse, Rat

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Antibodies