desaturase

By Targets:	Stearoyl-CoA Desaturase (SCD) (17) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (2) Ferroptosis (1) Fungal (2) Influenza Virus (1) Isotope-Labeled Compounds (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (7) Infection (3) Inflammation/Immunology (3) Metabolic Disease (11) Neurological Disease (2)

Targets Recommended: Stearoyl-CoA Desaturase (SCD)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151095

*Phytoene desaturase-IN-1*	Reactive Oxygen Species	Others
Phytoene desaturase-IN-1 is a potent *phytoene desaturase* (PDS) inhibitor (K_d*: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase*-IN-1 can be used in the area of agricultural production .

HY-141525

SCD1 inhibitor-4	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes .

HY-127143

Sterculic acid	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM .

HY-157024

Phytoene desaturase-IN-2

Others Others

PDS-IN-1 is a potent inhibitor of Oryza sativa phytoene desaturase (OsPDS), resulting in herbicidal activity .

*Phytoene desaturase-IN-2*	Others	Others
PDS-IN-1 is a potent inhibitor of Oryza sativa phytoene desaturase (OsPDS), resulting in herbicidal activity .

HY-135818

XM462	Others	Cancer
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (K_i=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC₅₀ values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor .

HY-114849

Norflurazon

SAN 9789
Others Others

Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .

Norflurazon SAN 9789	Others	Others
Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .

HY-124346

T-3364366 1 Publications Verification	Others	Metabolic Disease
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC₅₀s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC₅₀0=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC₅₀=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,₅₀ >10000 nM) in the enzymatic activity assay .

HY-134423

Stearoyl coenzyme A lithium Stearoyl-CoA lithium	Biochemical Assay Reagents	Others
Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

HY-145437

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide

Fungal Infection

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent .

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide	Fungal	Infection
N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent .

HY-107410

SC-26196 2 Publications Verification	Others	Inflammation/Immunology
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties .

HY-N0121

Sesamin 5 Publications Verification	Others	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N6807

Elemicin	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits *Stearoyl-CoA Desaturase* 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral** activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-112812

SCD1 inhibitor-1

Stearoyl-CoA Desaturase (SCD) Metabolic Disease Cancer

SCD1 inhibitor-1 is a potent and liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitor .

SCD1 inhibitor-1	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Cancer
SCD1 inhibitor-1 is a potent and liver-selective *stearoyl-CoA desaturase-1 (SCD1)* inhibitor .

HY-15700

PluriSIn 1 3 Publications Verification NSC 14613	Stearoyl-CoA Desaturase (SCD) Apoptosis	Cancer
PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor.

HY-102045

T-3764518

Stearoyl-CoA Desaturase (SCD) Metabolic Disease

T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC₅₀ of 4.7 nM.

T-3764518	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC₅₀ of 4.7 nM.

HY-15822

MF-438 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MF-438 is a potent and orally bioavailable *stearoyl-CoA desaturase* 1 (SCD1) inhibitor with an IC₅₀** of 2.3 nM for rSCD1 .

HY-N0121A

(-)-Sesamin	Others	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-50709

A939572 Maximum Cited Publications 29 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Cancer
A939572 is a potent, and orally bioavailable *stearoyl-CoA desaturase1 (SCD1)* inhibitor with IC₅₀ values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.

HY-19762

GSK1940029 2 Publications Verification SCD inhibitor 1	Stearoyl-CoA Desaturase (SCD)	Cancer
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.

HY-100249

XEN723	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively.

HY-11034

CVT-12012	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC₅₀s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

HY-114184

MK-8245 analog	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 analog (compound 6) is a potent *stearoyl-CoA desaturase* (SCD) inhibitor with an IC₅₀** of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects .

HY-155033

SSI-4	Stearoyl-CoA Desaturase (SCD)	Others
SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with ¹¹C, used as a ligand to in vivo small animal PET/CT imaging of SCD1 .

HY-13077

MK-8245 Trifluoroacetate 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.

HY-19796

Icomidocholic acid 1 Publications Verification Aramchol; C20-FABAC
Icomidocholic acid (Aramchol) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Icomidocholic acid has potential use in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) treatment .

HY-13070

MK-8245 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 is a potent, liver-targeted *stearoyl-CoA desaturase* (SCD) inhibitor, with IC₅₀**s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy .

HY-134423S

Stearoyl coenzyme A-13C18 lithium	Isotope-Labeled Compounds	Others
Stearoyl coenzyme A- ¹³C₁₈ (lithium) is the ¹³C labeled Stearoyl coenzyme A lithium[1]. Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes[2].

HY-130703

5-Dehydroepisterol	Fungal	Infection
5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities .

HY-124751

YTX-465	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
YTX-465 is a *stearoyl-CoA desaturase* (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC₅₀**s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies .

HY-115319

CP-24879 hydrochloride 1 Publications Verification	Ferroptosis	Inflammation/Immunology
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research .

HY-15823

CAY10566 5+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Cancer
CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC₅₀=7.9 nM or 6.8 nM) .

HY-117427

D5D-IN-326	Others	Metabolic Disease
D5D-IN-326 is a selective, orally active *delta-5 desaturase* (D5D) inhibitor, with IC₅₀**s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice .

HY-N7864

all-cis-4,7,10,13,16-Docosapentaenoic acid all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid	Biochemical Assay Reagents	Others
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

Cat. No.	Product Name

HY-L087

Anti-Obesity Compound Library	2338 compounds
Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries. MCE Anti-Obesity Compound Library owns a unique collection of 2338 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Anti-Obesity Compound Library

2338 compounds

Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries.

MCE Anti-Obesity Compound Library owns a unique collection of 2338 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

Cat. No.	Product Name	Type

HY-N7864

all-cis-4,7,10,13,16-Docosapentaenoic acid all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid	Biochemical Assay Reagents
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

all-cis-4,7,10,13,16-Docosapentaenoic acid

all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid

Biochemical Assay Reagents

Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.

HY-134423

Stearoyl coenzyme A lithium Stearoyl-CoA lithium	Biochemical Assay Reagents
Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-127143

Sterculic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Sterculiaceae Plants Inflammation/Immunology Disease Research Fields Sterculia foetida Linn.	Stearoyl-CoA Desaturase (SCD)
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM .

HY-N0121

Sesamin 5 Publications Verification	Classification of Application Fields Neurological Disease Anti-aging Sesamum indicum Linn. Source classification Lignans Phenylpropanoids Pedaliaceae Plants Disease Research Fields	Others
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N6807

Elemicin	Infection Asarum sieboldii Miq. Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits *Stearoyl-CoA Desaturase* 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral** activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N0121A

(-)-Sesamin	Classification of Application Fields Asarum forbesii Maxim. Source classification Lignans Other Diseases Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	E. coli Cell-free (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702429

	SCD1 Protein, Mouse (Cell-Free, His) Acyl-CoA desaturase 1; Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1	Mouse	E. coli Cell-free
	The SCD1 protein or stearoyl-CoA desaturase 1 utilizes O(2) and electrons to introduce the first double bond into a saturated fatty acyl-CoA substrate. This process produces an important mixture of 16:1 and 18:1 unsaturated fatty acids, essential for lipid biosynthesis. SCD1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived SCD1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SCD1 Protein, Mouse (Cell-Free, His) is 355 a.a., with molecular weight of 43.9 kDa.

HY-P702428

	SCD Protein, Human (Cell-Free, His) Stearoyl-CoA desaturase; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturase	Human	E. coli Cell-free
	SCD proteins (or stearoyl-CoA desaturases) critically catalyze the introduction of the first double bond into saturated fatty acyl-CoA substrates (such as palmitoyl-CoA and stearoyl-CoA). This process produces a mixture of 16:1 and 18:1 unsaturated fatty acids, which play a crucial role in lipid biosynthesis. SCD Protein, Human (Cell-Free, His) is the recombinant human-derived SCD protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SCD Protein, Human (Cell-Free, His) is 359 a.a., with molecular weight of 44.3 kDa.

Cat. No.	Product Name	Chemical Structure

HY-134423S

Stearoyl coenzyme A-13C18 lithium
Stearoyl coenzyme A- ¹³C₁₈ (lithium) is the ¹³C labeled Stearoyl coenzyme A lithium[1]. Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes[2].


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desaturase

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