dimeric

By Targets:	ADC Linker (1) Antibiotic (2) Apoptosis (5) Autophagy (1) Bacterial (6) Cholinesterase (ChE) (1) COX (1) Drug Metabolite (1) Endogenous Metabolite (2) Fluorescent Dye (1) Fungal (3) GABA Receptor (1) HCV (1) HCV Protease (1) HIV (2) HIV Integrase (1) HIV Protease (1) iGluR (1) Interleukin Related (3) NADPH Oxidase (1) NO Synthase (2) PD-1/PD-L1 (1) Reactive Oxygen Species (1) TNF Receptor (2) Topoisomerase (1)
By Research Areas:	Cancer (12) Infection (8) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3760

Dimeric coniferyl acetate

NO Synthase Inflammation/Immunology

Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .
HY-N12020

Volucrin

Others Others

Volucrin is a dimeric phenanthrene derivative that can be isolated from the orchid lusia volucris .
HY-N7672

Isoeuphorbetin

HCV Protease Infection

Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC₅₀ of 3.63 µg/mL .

Dimeric coniferyl acetate	NO Synthase	Inflammation/Immunology
Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .

Volucrin	Others	Others
Volucrin is a dimeric phenanthrene derivative that can be isolated from the orchid lusia volucris .

Isoeuphorbetin	HCV Protease	Infection
Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC₅₀ of 3.63 µg/mL .

HY-141410

*Fluticasone dimer* impurity**	Drug Metabolite	Others
Fluticasone dimer impurity is a dimeric impurity of Fluticasone Propionate . Fluticasone propionate is a corticosteroid with comparatively high receptor affinity and topical activity .

HY-N11078

Shizukaol G

Others Others

Shizukaol G is a dimeric sesquiterpene. Shizukaol G can be isolated from the roots of Chloranthus japonicus .

Shizukaol G	Others	Others
Shizukaol G is a dimeric sesquiterpene. Shizukaol G can be isolated from the roots of Chloranthus japonicus .

HY-N7330

Integracin B	HIV Integrase HIV	Infection
Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .

HY-121097

Diapocynin Dehydrodiacetovanillone	NADPH Oxidase	Neurological Disease Inflammation/Immunology
Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities .

HY-P2918

Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Others
Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-N3488

Isodiospyrin	Topoisomerase Bacterial Fungal	Infection Cancer
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-108822

Rilonacept Arcalyst; IL 1 Trap; Interleukin 1 Trap	Interleukin Related	Inflammation/Immunology
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes .

HY-W073524

DFAME	Fluorescent Dye	Cancer
DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (K_d=460nM) and Corn-DFAME (K_d= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

HY-N11803

Arundanine

Others Others

Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .
HY-N1301

Shizukaol C

Others Others

Shizukaol C is a dimeric sesquiterpene isolated from the roots of Chloranthus serratus .
HY-B1292

Iodipamide

1 Publications Verification

Adipiodone

Iodipamide is a tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging.
HY-N3576

Henriol B

Chloramultilide D
Others Others

Henriol B (Chloramultilide D) is a dimeric sesquiterpenoid that can be isolated from C. spicatus .
HY-N12308

Monbarbatain A

Others Others

Monbarbatain A (compound 1) is a dimeric phenanthrene. Monbarbatain A can be isolated from the orchids Monomeria barbata .
HY-N3045

(S,S)-Pisatin

Others Others

(S,S)-Pisatin (compound 8) is a dimeric pterocarpan derivative is isolated from the grains of millettia pachyloba .
HY-N1302

Shizukaol D

Apoptosis Cancer

Shizukaol D is a dimeric sesquiterpene isolated from Chloranthus serratus. Shizukaol D induces apoptosis and attenuated Wnt signalling .

Arundanine	Others	Others
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .

Shizukaol C	Others	Others
Shizukaol C is a dimeric sesquiterpene isolated from the roots of Chloranthus serratus .

Iodipamide 1 Publications Verification Adipiodone
Iodipamide is a tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging.

Henriol B Chloramultilide D	Others	Others
Henriol B (Chloramultilide D) is a dimeric sesquiterpenoid that can be isolated from C. spicatus .

Monbarbatain A	Others	Others
Monbarbatain A (compound 1) is a dimeric phenanthrene. Monbarbatain A can be isolated from the orchids Monomeria barbata .

(S,S)-Pisatin	Others	Others
(S,S)-Pisatin (compound 8) is a dimeric pterocarpan derivative is isolated from the grains of millettia pachyloba .

Shizukaol D	Apoptosis	Cancer
Shizukaol D is a dimeric sesquiterpene isolated from Chloranthus serratus. Shizukaol D induces apoptosis and attenuated Wnt signalling .

HY-N144684

Himastatin	Bacterial	Infection Cancer
Himastatin is a antitumor antibiotic produced by a strain of S. hygroscopicus sp. Himastatin is a dimeric cyclohexadepsipeptide containing piperazic acid and a unique central aromatic core .

HY-77817

Pyrrole-2-carboxaldehyde	Others	Others
Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .

HY-N11108

Gochnatiolide A	Others	Cancer
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines .

HY-151165

LasR-IN-3	Bacterial Antibiotic	Infection
LasR-IN-3 is a LasR inhibitor against Pseudomonas aeruginosa. LasR-IN-3 induces LasR structure instability and completely dissociates LasR functioning dimeric form .

HY-P2740

Alcohol dehydrogenase EC 1.1.1.1	Endogenous Metabolite	Metabolic Disease
Alcohol dehydrogenase is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Others	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-N7765

Oenothein B	HCV Bacterial Apoptosis Fungal	Infection Inflammation/Immunology Cancer
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase .

HY-116700

Hinnuliquinone	HIV Protease HIV	Infection
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .

HY-108847

Etanercept 4 Publications Verification	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Inflammation/Immunology
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1 .

HY-W040129

Chromomycin A3	Bacterial Fungal Apoptosis Antibiotic	Infection Cancer
Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg ²⁺, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor .

HY-120970

Bis(7)-tacrine dihydrochloride	Cholinesterase (ChE) GABA Receptor iGluR	Neurological Disease
Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABA_Areceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease .

HY-12855

Lys01	Autophagy	Cancer
Lys01, a dimeric form of Chloroquine (HY-17589A), is an autophagy inhibitor. Lys01 inhibits cell viability of 1205Lu, c8161, LN229, HT-29 cells with IC₅₀s of 3.6, 3.8, 7.9, 6.0 μM. Lys01 can be used for anticancer research .

HY-N8371

Shizukaol B	NO Synthase COX Interleukin Related TNF Receptor	Inflammation/Immunology
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

HY-19745

BMS-202 Maximum Cited Publications 15 Publications Verification	PD-1/PD-L1 Apoptosis	Cancer
BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC₅₀ of 18 nM and a K_D of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept, also known as N-803 (Nogapendekin alfa inbakicept), contains the IL-15 cytokine antibody Nogapendekin alfa (HY-P99759). Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). Inbakicept also increases degranulation and IFNγ production in cells .

HY-151746

N3-Gly-Gly-Gly-OH	ADC Linker	Others
N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved . N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library	805 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 805 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

NF-κB Signaling Compound Library

805 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 805 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-W073524

DFAME	Fluorescent Dyes/Probes
DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (K_d=460nM) and Corn-DFAME (K_d= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

DFAME

Fluorescent Dyes/Probes

DFAME is a red fluorophore (Ex=508 nm, Em=641 nm). Beetroot and Corn are dimeric fluorogenic RNA aptamers that can bind to DFAME to form Beetroot-DFAME (K_d=460nM) and Corn-DFAME (K_d= 3600nM). Beetroot-DFAME (Kd=460nM) and Corn-DFAME can be used to form RNA assemblies in living cells. Creating RNA assemblies can be used for the study of RNA Nanostructures. DNA/RNA Nanostructures would be useful in cell and gene therapy (CGT) research .

Cat. No.	Product Name	Type

HY-107903

Thyroglobulin Thyroglobulin from bovine	Native Proteins
Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle .

HY-P2740

Alcohol dehydrogenase EC 1.1.1.1	Biochemical Assay Reagents
Alcohol dehydrogenase is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol .

Cat. No.	Product Name	Target	Research Area

HY-108822

Rilonacept Arcalyst; IL 1 Trap; Interleukin 1 Trap	Interleukin Related	Inflammation/Immunology
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes .

HY-108847

Etanercept 4 Publications Verification	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-P99879

Efbemalenograstim alfa Benegrastim; Bineuta; F 627	Inhibitory Antibodies	Inflammation/Immunology
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept, also known as N-803 (Nogapendekin alfa inbakicept), contains the IL-15 cytokine antibody Nogapendekin alfa (HY-P99759). Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). Inbakicept also increases degranulation and IFNγ production in cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3760

Dimeric coniferyl acetate	Structural Classification Monophenols Source classification Jatropha integerrima Jacq. Phenols Euphorbiaceae Plants	NO Synthase
Dimeric coniferyl acetate is a NO production inhibitor with an IC₅₀ value 7.9 μM in BV-2 microglial cells .

HY-N12020

Volucrin	Structural Classification Dioscorea polystachya Turczaninow Source classification Phenols Polyphenols Plants Dioscoreaceae	Others
Volucrin is a dimeric phenanthrene derivative that can be isolated from the orchid lusia volucris .

HY-N7672

Isoeuphorbetin	Infection Classification of Application Fields Gramineae Source classification Coumarins Phenols Polyphenols Leptochloa chinensis (Linn.) Nees Phenylpropanoids Plants Disease Research Fields	HCV Protease
Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC₅₀ of 3.63 µg/mL .

HY-N11078

Shizukaol G	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Others
Shizukaol G is a dimeric sesquiterpene. Shizukaol G can be isolated from the roots of Chloranthus japonicus .

HY-N7330

Integracin B	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HIV Integrase HIV
Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .

HY-N3488

Isodiospyrin	Quinones Structural Classification other families Diospyros virginiana L. Source classification Benzene Quinones Plants	Topoisomerase Bacterial Fungal
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N11803

Arundanine	Structural Classification Alkaloids Gramineae Source classification Plants Arundo donax Linn. Indole Alkaloids	Others
Arundanine is an dimeric alkaloid, which can be isolated from Arundo donax. .

HY-N1301

Shizukaol C	Chloranthus spicatus (Thunb.) Makino Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Others
Shizukaol C is a dimeric sesquiterpene isolated from the roots of Chloranthus serratus .

HY-N3576

Henriol B Chloramultilide D	Chloranthus spicatus (Thunb.) Makino Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Others
Henriol B (Chloramultilide D) is a dimeric sesquiterpenoid that can be isolated from C. spicatus .

HY-N12308

Monbarbatain A	Structural Classification Natural Products Orchidaceae Source classification Plants Bulbophyllum emarginatum (Finet) J. J. Smith	Others
Monbarbatain A (compound 1) is a dimeric phenanthrene. Monbarbatain A can be isolated from the orchids Monomeria barbata .

HY-N3045

(S,S)-Pisatin	Natural Products Classification of Application Fields Leguminosae Source classification Other Diseases Pisum sativum Linn Plants Disease Research Fields	Others
(S,S)-Pisatin (compound 8) is a dimeric pterocarpan derivative is isolated from the grains of millettia pachyloba .

HY-N1302

Shizukaol D	Structural Classification Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Apoptosis
Shizukaol D is a dimeric sesquiterpene isolated from Chloranthus serratus. Shizukaol D induces apoptosis and attenuated Wnt signalling .

HY-N144684

Himastatin	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Cyclopeptides Anticancer Disease Research Fields Cancer	Bacterial
Himastatin is a antitumor antibiotic produced by a strain of S. hygroscopicus sp. Himastatin is a dimeric cyclohexadepsipeptide containing piperazic acid and a unique central aromatic core .

HY-77817

Pyrrole-2-carboxaldehyde	Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .

HY-N11108

Gochnatiolide A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Gochnatia polymorpha (Less) Cabr.	Others
Gochnatiolide A is a dimeric sesquiterpene that can be found in Ainsliaea henryi. Gochnatiolide A exhibits antiproliferative activity against the kidney, melanoma, ovarian-resistant and glioma cell lines .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Structural Classification Flavonoids Microorganisms Xanthones Source classification Phenols Other Flavonoids	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-N7765

Oenothein B	Infection Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	HCV Bacterial Apoptosis Fungal
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase .

HY-116700

Hinnuliquinone	Structural Classification Natural Products Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	HIV Protease HIV
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .

HY-N3071

Picrasidine I	Simaroubaceae Source classification Plants Quassia amaraL. Indole Alkaloids	Apoptosis Reactive Oxygen Species
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1 .

HY-N8371

Shizukaol B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression .

Cat. No.	Compare	Product Name	Species	Source

HY-P75568

	ALDH3A1 Protein, Human (sf9, His) Aldehyde dehydrogenase, dimeric NADP-preferring; Aldehyde Dehydrogenase 3 member A1; ALDHIII; ALDH3	Human	Sf9 insect cells
	The ALDH3A1 protein is critical for acetaldehyde detoxification in alcohol metabolism, oxidizing medium- and long-chain aldehydes to nontoxic fatty acids. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 Protein, Human (sf9, His) is the recombinant human-derived ALDH3A1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of ALDH3A1 Protein, Human (sf9, His) is 453 a.a., with molecular weight of ~50 kDa.

Cat. No.	Product Name		Classification

HY-151746

N3-Gly-Gly-Gly-OH		Azide
N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved . N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.


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