dystonia

By Targets:	Apoptosis (1) Isotope-Labeled Compounds (1)
By Research Areas:	Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12347

Ro 61-8048 2 Publications Verification	Others	Neurological Disease
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC₅₀ of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .

HY-B1139

Tolperisone hydrochloride 1 Publications Verification	Apoptosis	Neurological Disease
Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .

HY-B1139S

Tolperisone-d10 hydrochloride	Isotope-Labeled Compounds	Neurological Disease
Tolperisone-d₁₀ (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	P. pastoris (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73564

	Tyrosine Hydroxylase Protein, Human (sf9, His) DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Human	Sf9 insect cells
	Tyrosine hydroxylase is a key enzyme in the biosynthesis of catecholamines, catalyzing the conversion of L-tyrosine into L-dopa, which is the rate-limiting step in the synthesis of dopamine, norepinephrine, and epinephrine. Tyrosine is hydroxylated using tetrahydrobiopterin and oxygen. Tyrosine Hydroxylase Protein, Human (sf9, His) is the recombinant human-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Tyrosine Hydroxylase Protein, Human (sf9, His) is 496 a.a., with molecular weight of ~57.6 kDa.

HY-P71840

	DST Protein, Human (P.pastoris, His) DST; BPAG1; DMH; DT; dystonia musculorum protein; Hemidesmosomal plaque protein	Human	P. pastoris
	DST proteins integrate intermediate filaments, actin, and microtubule networks. DST Protein, Human (P.pastoris, His) is the recombinant human-derived DST protein, expressed by P. pastoris , with N-His labeled tag. The total length of DST Protein, Human (P.pastoris, His) is 195 a.a., with molecular weight of ~23.7 kDa.

HY-P73563

	Tyrosine Hydroxylase Protein, Mouse (sf9, His) DYT14; TH; TYH dystonia 14; TYH; Tyrosine 3-monooxygenase	Mouse	Sf9 insect cells
	The Tyrosine Hydroxylase protein serves as a crucial catalyst in the biosynthesis of catecholamines, including dopamine, noradrenaline, and adrenaline, overseeing the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa)—a pivotal and rate-limiting step in this biochemical pathway. Through the utilization of tetrahydrobiopterin and molecular oxygen, Tyrosine Hydroxylase efficiently transforms tyrosine into L-Dopa, showcasing its central role in the production of essential neurotransmitters. Beyond its primary function, the enzyme exhibits versatility by also catalyzing the hydroxylation of phenylalanine and tryptophan, albeit with lower specificity. Intriguingly, Tyrosine Hydroxylase extends its influence to developmental processes, positively regulating the regression of retinal hyaloid vessels during postnatal development, highlighting its multifaceted engagement in both neurotransmitter synthesis and physiological development. Tyrosine Hydroxylase Protein, Mouse (sf9, His) is the recombinant mouse-derived Tyrosine Hydroxylase protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Tyrosine Hydroxylase Protein, Mouse (sf9, His) is 497 a.a., with molecular weight of ~65 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-B1139S

Tolperisone-d10 hydrochloride
Tolperisone-d₁₀ (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

Tolperisone-d10 hydrochloride

Tolperisone-d₁₀ (hydrochloride) is the deuterium labeled Tolperisone hydrochloride. Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.

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