Search Result

Results for "

eEF2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (2) Apoptosis (2) Autophagy (2) Bacterial (2) CaMK (7) COX (1) EGFR (1) Fungal (2) Parasite (2) PKA (1) PKC (1) PROTACs (1) Small Interfering RNA (siRNA) (2) Src (1) Virus Protease (1)
By Research Areas:	Cancer (5) Infection (4) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Sordarin sodium	CaMK Fungal Antibiotic	Infection Inflammation/Immunology
Sordarin is a potent diphthamide-dependent *eEF2* inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae) ^[2].

Cabamiquine DDD107498; DDD-498; M5717	Parasite CaMK	Infection
Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC₅₀ of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting *eEF2/CaMKIII, with an EC₅₀* of 2 nM for WT-PfeEF2 .

Cabamiquine succinate DDD107498 succinate; DDD-498 succinate; M5717 succinate	Parasite CaMK	Infection
Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC₅₀ of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting *eEF2/CaMKIII, with an EC₅₀* of 2 nM for WT-PfeEF2 .

EEF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EEF2 Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EEF2 Human Pre-designed siRNA Set A EEF2 Human Pre-designed siRNA Set A

EEF2K Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EEF2K Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EEF2K Human Pre-designed siRNA Set A EEF2K Human Pre-designed siRNA Set A

AMPK-IN-1	AMPK	Metabolic Disease
AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform *α2β2γ1). AMPK-IN-1 leads to eEF2* phosphorylation in a mTORC1-independent way ^[2] .

NH125 1 Publications Verification	CaMK Autophagy Bacterial Fungal Virus Protease	Cancer
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase *(eEF-2K/CaMKIII), also can induce eEF2* phosphorylation, with an IC₅₀ of 60 nM for eEF-2K ^[2].

TX-1123	Src CaMK PKA EGFR PKC COX	Cancer
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC₅₀ values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer ^[2].

*PROTAC eEF2K degrader-1*	PROTACs CaMK Apoptosis	Cancer
PROTAC eEF2K degrader-1 (Compound 11l) is an *eEF2K*-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .

A-484954 4 Publications Verification	CaMK Autophagy	Cancer
A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.

Cefatrizine BL-S-640; SK&F 60771	Apoptosis Bacterial Antibiotic	Infection Cancer
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a *eEF2K* inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection ^[2].

Cat. No.	Compare	Product Name	Species	Source

	EEF2K Protein, Human eEF2K; Eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase	Human	E. coli
	EEF2K, a threonine kinase, critically regulates protein synthesis by modulating peptide chain elongation. Activation by upstream kinases like AMPK or TRPM7 leads to phosphorylation of EEF2, inhibiting its binding to ribosomes and decelerating protein synthesis. EEF2K's intricate control underscores its pivotal role in modulating cellular processes related to protein translation. EEF2K Protein, Human is the recombinant human-derived EEF2K protein, expressed by E. coli , with tag free. The total length of EEF2K Protein, Human is 724 a.a., .

	EEF2K Protein, Human (GST) eEF2K; Eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase	Human	E. coli
	EEF2K, a threonine kinase, critically regulates protein synthesis by modulating peptide chain elongation. Activation by upstream kinases like AMPK or TRPM7 leads to phosphorylation of EEF2, inhibiting its binding to ribosomes and decelerating protein synthesis. EEF2K's intricate control underscores its pivotal role in modulating cellular processes related to protein translation. EEF2K Protein, Human (GST) is the recombinant human-derived EEF2K protein, expressed by E. coli , with N-GST labeled tag. The total length of EEF2K Protein, Human (GST) is 724 a.a., .


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Name
Email *

	Sorry, but the email address you supplied was invalid.