Search Result

Results for "

edema

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (2) Adrenergic Receptor (1) Apoptosis (6) Bacterial (2) Calcium Channel (3) Carbonic Anhydrase (1) Caspase (3) CCR (2) COX (19) CRFR (1) CXCR (1) Drug Metabolite (1) EBV (1) Endogenous Metabolite (3) Fluorescent Dye (1) GABA Receptor (4) Glucocorticoid Receptor (1) Glucosidase (1) Glutathione S-transferase (3) Guanylate Cyclase (2) IKK (1) Influenza Virus (2) Integrin (1) Interleukin Related (7) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) Leukotriene Receptor (1) Lipoxygenase (1) LPL Receptor (1) Microtubule/Tubulin (2) Monoamine Oxidase (2) NF-κB (7) NKCC (4) NO Synthase (5) Opioid Receptor (2) PGC-1α (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PKA (1) Platelet-activating Factor Receptor (PAFR) (1) Progesterone Receptor (1) PROTAC Linkers (2) Reactive Oxygen Species (2) RIP kinase (2) ROS Kinase (1) Ser/Thr Protease (4) STAT (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Vasopressin Receptor (2) VEGFR (2)
By Research Areas:	Cancer (20) Cardiovascular Disease (11) Endocrinology (1) Infection (7) Inflammation/Immunology (61) Metabolic Disease (14) Neurological Disease (9)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113456

Leukotriene D4	Drug Metabolite Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability .

HY-142123

Fluocortolone	Others	Inflammation/Immunology
Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg) .

HY-W021267

3-Demethylcolchicine	Reactive Oxygen Species	Inflammation/Immunology
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .

HY-137431A

(R)-Asundexian (R)-BAY-2433334	Others	Cardiovascular Disease
(R)-Asundexian ((R)-BAY-2433334) is the enantiomer of Asundexian (HY-137431). (R)-Asundexian can be used in studies of cardiovascular disease (especially thrombotic or thromboembolic disease), edema, and ophthalmic disease .

HY-162166

COX-2/15-LOX/mPGES-1-IN-1	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX/mPGES-1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC₅₀ values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES-1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .

HY-17417A

Naloxone	Opioid Receptor	Neurological Disease
Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .

HY-N11538

Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside	Others	Inflammation/Immunology
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury .

HY-155405

Anti-inflammatory agent 64	ROS Kinase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of IL-6 and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema .

HY-157220

Tolvaptan phosphate ester sodium	Vasopressin Receptor	Cardiovascular Disease
Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation .

HY-P99116

Faricimab RG7716	VEGFR	Metabolic Disease
Faricimab is a bispecific antibody targeting angiopoietin-2 and vascular endothelial growth factor-A (VEGF-A). Faricimab can be used for diabetic macular edema (DME) research .

HY-16403

Polythiazide	Others	Cardiovascular Disease
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity .

HY-N2478

Taraxasteryl acetate	Others	Inflammation/Immunology
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment ^{[1] ^.}

HY-143476

Plasma kallikrein-IN-2	Ser/Thr Protease	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC₅₀ of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-134371

IL-17 modulator 2	Interleukin Related	Inflammation/Immunology
IL-17 modulator 2 (compound 159) is an orally active modulator of IL-17. IL-17 modulator 2 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 2 can used in study arthritis .

HY-160026

IL-17 modulator 8	Interleukin Related	Inflammation/Immunology
IL-17 modulator 8 (compound 286) is an orally active modulator of IL-17. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis .

HY-160028

IL-17 modulator 9	Interleukin Related	Inflammation/Immunology
IL-17 modulator 9 (compound 453) is an orally active modulator of IL-17. IL-17 modulator 9 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 9 can used in study inflammation .

HY-118725

Luffariellolide	Phospholipase	Inflammation/Immunology
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-146054

CXCR4 modulator-2	CXCR	Inflammation/Immunology
CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC₅₀ value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t_1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model .

HY-W013164

SC-58125	COX	Inflammation/Immunology Cancer
SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC₅₀ of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect .

HY-W008574

TGN-020 5+ Cited Publications	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-W008574A

TGN-020 sodium 5+ Cited Publications	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-P3130

Stresscopin-related peptide (human)	CRFR	Neurological Disease Inflammation/Immunology
Stresscopin-related peptide (human) is a specific ligand for the type 2 CRH receptor. Stresscopin-related peptide (human) suppresses food intake, delayed gastric emptying and decreases heat-induced edema. Stresscopin-related peptide (human) maintains homeostasis after stress, and can be used in the research of stress-related diseases .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Influenza Virus	Infection
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-101872

GSK-872 Maximum Cited Publications 55 Publications Verification	RIP kinase	Inflammation/Immunology
GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

HY-101872A

GSK-872 hydrochloride Maximum Cited Publications 55 Publications Verification	RIP kinase	Inflammation/Immunology
GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .

HY-B0135

Furosemide 2 Publications Verification	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-B0135A

Furosemide sodium 2 Publications Verification	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide sodium is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide sodium is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-N1143

Tomentin	Others	Inflammation/Immunology
Tomentin is a compound isolated from Sphaeralcea angustifolia. Tomentin inhibits the formation of λ-carrageenan footpad edema at 58 %. Tomentin inhibits the phorbol ester-induced auricular edema formation by 57 % .

HY-155820

Anti-inflammatory agent 54	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-155821

Anti-inflammatory agent 55	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Metabolic Disease Cancer
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

HY-D1782

Selenomethylene blue	Fluorescent Dye	Inflammation/Immunology
Selenomethylene blue is an antioxidant and anti-inflammatory agent. Selenomethylene blue effectively inhibits the inflammatory paw edema in rats .

HY-B0580

Ketorolac RS37619	COX Apoptosis	Inflammation/Immunology Cancer
Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .

HY-B0580C

Ketorolac hemicalcium RS37619 hemicalcium	COX Apoptosis	Inflammation/Immunology Cancer
Ketorolac (RS37619) hemicalcium is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorola chemicalcium is also a DDX3 inhibitor that can be used for cancer research .

HY-N12243

Kopsininic acid	Others	Others
Kopsininic acid is a natural product derived from Kopsia hainanensis. Kopsininic acid can be used in the research of rheumatoid arthritis, pharyngitis, tonsillitis and edema .

HY-17417

Naloxone hydrochloride 2 Publications Verification	Opioid Receptor	Neurological Disease
Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias .

HY-100174

W-2429 NSC294836	Others	Neurological Disease
W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats .

HY-157226

ORI-TRN-002

Others Others

ORI-TRN-002 is an AQP4 inhibitor with an IC₅₀ value of 3μM. ORI-TRN-002 can be used in the research area of cerebral edema .

ORI-TRN-002	Others	Others
ORI-TRN-002 is an AQP4 inhibitor with an IC₅₀ value of 3μM. ORI-TRN-002 can be used in the research area of cerebral edema .

HY-N9508

Perilla ketone	Others	Inflammation/Immunology
Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema .

HY-B2081

Etozolin W-2900A
Etozolin (W-2900A) is a diuretic agent. Etozolin inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin can be used in research of congestive heart failure, hypertension and edema .

HY-B0135S

Furosemide-d5	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

HY-150052

Plasma kallikrein-IN-3	Ser/Thr Protease	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-3 is a plasma kallikrein inhibitor (IC₅₀: 0.15 μM). Plasma kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-106628

Sudoxicam	COX	Inflammation/Immunology
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-133712

Yonkenafil Tunodafil	Phosphodiesterase (PDE)	Neurological Disease
Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease .

HY-145633

Sozinibercept OPT 302; VGX-300	VEGFR	Cardiovascular Disease
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats .

HY-109133

Pecavaptan BAY 1753011	Vasopressin Receptor	Neurological Disease Metabolic Disease
Pecavaptan is an orally active and dual antagonist of V1a/V2 receptor (K_i=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema .

HY-125095

Yonkenafil hydrochloride Tunodafil hydrochloride	Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease
Yonkenafil (Tunodafil) hydrochloride, a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil (Tunodafil) hydrochloride may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease .

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-P0095

Acetyl tetrapeptide-5
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113456

Leukotriene D4	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite
Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability .

HY-W021267

3-Demethylcolchicine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .

HY-N2478

Taraxasteryl acetate	Triterpenes Classification of Application Fields Terpenoids Source classification Astragalus oleifolius DC. Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment ^{[1] ^.}

HY-N11538

Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside	Structural Classification Flavonoids Classification of Application Fields Polygonaceae Source classification Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Polygonum capitatum Buch.-Ham. ex D. Don Prodr	Others
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury .

HY-118725

Luffariellolide	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Inflammation/Immunology	Phospholipase
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-N1143

Tomentin	Malvaceae Classification of Application Fields Source classification Coumarins Sphaeralcea angustifolia (Cav.) G.Don Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	Others
Tomentin is a compound isolated from Sphaeralcea angustifolia. Tomentin inhibits the formation of λ-carrageenan footpad edema at 58 %. Tomentin inhibits the phorbol ester-induced auricular edema formation by 57 % .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

HY-N12243

Kopsininic acid	Apocynaceae Kopsia hainanensis Tsiang Structural Classification Alkaloids Source classification Plants Indole Alkaloids	Others
Kopsininic acid is a natural product derived from Kopsia hainanensis. Kopsininic acid can be used in the research of rheumatoid arthritis, pharyngitis, tonsillitis and edema .

HY-N9508

Perilla ketone	Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz. Disease Research Fields Inflammation/Immunology	Others
Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema .

HY-N2556

Tirucallol	Triterpenes Classification of Application Fields Euphorbia boetica Terpenoids Source classification Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology	Others
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N2041

Myristic acid 2 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Endogenous Metabolite NF-κB Bacterial
Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-N0123

Aloin Maximum Cited Publications 7 Publications Verification Aloin-A; Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Cancer	Others
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-N8160

Dehydrocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Zingiberaceae	Keap1-Nrf2 Reactive Oxygen Species
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-129143

Delphinidin-3-sambubioside chloride Dp3‐Sam chloride	Malvaceae Structural Classification Flavonoids Hibiscus sabdariffa Linn. Plants Other Flavonoids	Others
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L. .

HY-W109812

Sinapyl alcohol	Structural Classification Monophenols Microorganisms Source classification Phenols	COX
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .

HY-N7015

Zerumbone	Infection Structural Classification Natural Products Zingiber zerumbet Classification of Application Fields Source classification Plants Disease Research Fields Zingiberaceae	EBV Caspase Apoptosis Bacterial
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

Cat. No.	Product Name	Chemical Structure

HY-B0135S

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

HY-B1888AS

Bromfenac-d4 sodium

Bromfenac-d₄ (sodium) is deuterium labeled Bromfenac (sodium). Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium is a brominated non-steroidal anti-inflammatory/analgesic agent (NSAID), and it is commonly used for the research of postoperative inflammation and pain following cataract surgery, and pseudophakic cystoid macular edema (CME)[1][2].

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-W109812S

Sinapyl alcohol-d3
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks